MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Congenital Hyperinsulinism

(UMLS:C3888018)

Definition:: A familial, nontransient HYPOGLYCEMIA with defects in negative feedback of GLUCOSE-regulated INSULIN release. Clinical phenotypes include HYPOGLYCEMIA; HYPERINSULINEMIA; SEIZURES; COMA; and often large BIRTH WEIGHT. Several sub-types exist with the most common, type 1, associated with mutations on an ATP-BINDING CASSETTE TRANSPORTERS (subfamily C, member 8).
UMLS ID:: C3888018
MeSH ID:: D044903

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.689.150

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.614.200

Classification 3:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.394.968.250|C18.452.394.984.200

Synonym(s)

Congenital Hyperinsulinism

Congenital hyperinsulinism

HHI

Hyperinsulinemia of Infancy

Hyperinsulinemic Hypoglycemia

Neonatal Hyperinsulinism

Persistent Hyperinsulinemic Hypoglycemia of Infancy

Persistent hyperinsulinemic hypoglycemia of infancy

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Diazoxide		2684032 10923237	CTD
2	Octreotide		10923237	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperglycemia	28.4%
2	Insulin Resistance	24.4%
3	Diabetes Mellitus	24.4%
4	Cystic Fibrosis	24.3%
5	Wasting Syndrome	23%
6	Acid-Base Imbalance	20.5%
7	Calcium Metabolism Disorders	20.5%
8	Iron Metabolism Disorders	20.5%
9	Phosphorus Metabolism Disorders	20.5%
10	Water-Electrolyte Imbalance	20.5%
11	Lipid Metabolism Disorders	20.5%
12	Mitochondrial Diseases	20.5%
13	Hypercalcemia	20.2%
14	Hypocalcemia	20.2%
15	Milk-Alkali Syndrome	20.2%
16	Glycosuria	20.1%
17	Pseudohypoparathyroidism	19.6%
18	Leigh Disease	18%
19	Diabetic Ketoacidosis	17.6%
20	Brain Diseases, Metabolic, Inborn	17.6%
21	Lipodystrophy	17.3%
22	Osteopenia	17.2%
23	Smith-Lemli-Opitz Syndrome	17.2%
24	Brain Diseases, Metabolic	17%
25	Lactose Intolerance	16.6%
26	Abdominal Cramps	16.4%
27	Amniotic Band Syndrome	16.4%
28	Asphyxia Neonatorum	16.4%
29	Infant, Premature, Diseases	16.4%
30	Pancreatic Insufficiency	16.4%
31	Pancreatitis	16.4%
32	Infantile Colic	16.4%
33	Rickets	16.1%
34	Carbamoyl-Phosphate Synthase I Deficiency Disease	16%
35	Pancreatic Fistula	15.6%
36	Hyperhomocysteinemia	15.5%
37	Galactosemias	15.1%
38	Urea Cycle Disorders, Inborn	15.1%
39	Tyrosinemias	15.1%
40	Werner Syndrome	14.8%
41	Hyperinsulinism	14.2%
42	Hypoglycemia	14.2%
43	Zellweger Syndrome	14.2%
44	Sjogren-Larsson Syndrome	13.8%
45	Pancreatic Cyst	13.8%
46	Hypolipoproteinemias	13.7%
47	Hyperphosphaturia	13.7%
48	Gestational Diabetes	13.7%
49	Latent Autoimmune Diabetes in Adults	13.7%
50	Anemia, Neonatal	13.6%
51	Persistent Fetal Circulation Syndrome	13.6%
52	Porphyrias, Hepatic	13.6%
53	Diabetes Mellitus, Experimental	13.5%
54	Umbilical hernia	13.5%
55	Achlorhydria	13.5%
56	Amino Acid Metabolism, Inborn Errors	13.5%
57	Bloom Syndrome	13.5%
58	Carbohydrate Metabolism, Inborn Errors	13.5%
59	Metal Metabolism, Inborn Errors	13.5%
60	Progeria	13.5%
61	Lysosomal Storage Diseases	13.5%
62	Cytochrome-c Oxidase Deficiency	13.5%
63	Peroxisomal Disorders	13.5%
64	Glycosuria, Renal	13.4%
65	Glycogen storage disease type II	13.4%
66	Ichthyosis, X-Linked	13.2%
67	Hepatolenticular Degeneration	13.2%
68	Hyperlipoproteinemia Type IV	13.1%
69	Hyperlipoproteinemia Type V	13.1%
70	Familial Hypophosphatemic Rickets	13.1%
71	Menkes Kinky Hair Syndrome	13.1%
72	Celiac Disease	12.8%
73	Sprue, Tropical	12.8%
74	Steatorrhea	12.8%
75	Sprue	12.8%
76	Gaucher Disease	12.8%
77	Adrenoleukodystrophy	12.7%
78	Homocystinuria	12.7%
79	Xeroderma	12.7%
80	Mobius Syndrome	12.7%
81	Nutrition Disorders	12.7%
82	Hyperlipidemia, Familial Combined	12.3%
83	Amyloid Neuropathies, Familial	12.3%
84	Meconium Aspiration Syndrome	12.2%
85	Pancreatic Neoplasm	12.2%
86	Refsum Disease	12.2%
87	Acidosis	12.2%
88	Alkalosis	12.2%
89	Amyloidosis	12.2%
90	Calcinosis	12.2%
91	Hyperkalemia	12.2%
92	Hypernatremia	12.2%
93	Hypokalemia	12.2%
94	Hyponatremia	12.2%
95	Xanthomatosis	12.2%
96	Hypophosphatemia	12.2%
97	Pancreatitis, Chronic	12.2%
98	Metabolic acidosis	12.2%
99	Dyslipidemias	12.2%
100	Iron Overload	12.2%
101	Xanthoma	12.2%
102	Kernicterus	12.1%
103	Cockayne Syndrome	12%
104	Neonatal Abstinence Syndrome	11.9%
105	Congenital Hyperinsulinism	11.9%
106	Fabry Disease	11.6%
107	Congenital nystagmus	11.6%
108	Neuronal Ceroid-Lipofuscinoses	11.6%
109	Hyperlipoproteinemia Type III	11.6%
110	Toxoplasmosis, Congenital	11.5%
111	Reye Syndrome	11.5%
112	Syphilis, Congenital	11.5%
113	Mitochondrial Encephalomyopathies	11.1%
114	Tay-Sachs Disease	11%
115	Hepatic Encephalopathy	11%
116	Osteomalacia	10.8%
117	Niemann-Pick Disease, Type C	10.7%
118	Renal tubular acidosis	10.6%
119	Hypoalphalipoproteinemias	10.6%
120	Dehydration	10.2%
121	Lipomatosis	10.2%
122	Paralysis, Obstetric	10.2%
123	Retinopathy of Prematurity	10.2%
124	Water Intoxication	10.2%
125	Zollinger-Ellison syndrome	10.1%
126	Osteoporosis	10.1%
127	Pancreatic Pseudocyst	10.1%
128	Bone Demineralization, Pathologic	10.1%
129	Post-Traumatic Osteoporosis	10.1%
130	Bronchopulmonary Dysplasia	10.1%
131	Pancreatitis, Alcoholic	10.1%
132	Mucopolysaccharidosis II	10%
133	Fanconi Anemia	10%
134	Mucopolysaccharidosis III	9.8%
135	Esophageal Atresia	9.7%
136	Intestinal Atresia	9.7%
137	Variegate Porphyria	9.5%
138	Acute intermittent porphyria	9.5%
139	Porphyria Cutanea Tarda	9.5%
140	MELAS Syndrome	9.5%
141	Alkaptonuria	9.4%
142	Glycogen Storage Disease	9.4%
143	Hypophosphatasia	9.4%
144	Propionic acidemia	9.4%
145	Dihydropyrimidine Dehydrogenase Deficiency	9.4%
146	Cystinosis	9.4%
147	HIV Wasting Syndrome	8.9%
148	Respiratory Distress Syndrome, Newborn	8.8%
149	Albinism	8.8%
150	Mitochondrial Myopathies	8.7%
151	Nesidioblastosis	8.7%
152	Myelinolysis, Central Pontine	8.7%
153	Beckwith-Wiedemann Syndrome	8.7%
154	Wolf-Hirschhorn Syndrome	8.7%
155	Proctocolitis	8.6%
156	Choledochal Cyst	8.5%
157	Holoprosencephaly	8.5%
158	Aicardi's syndrome	8.5%
159	Biliary Tract Diseases	8.5%
160	Gastrointestinal Diseases	8.5%
161	Liver diseases	8.5%
162	Deformity	8.5%
163	Genetic Diseases, Inborn	8.5%
164	Friedreich Ataxia	8.4%
165	Xeroderma Pigmentosum	8.4%
166	Optic Atrophy, Hereditary, Leber	8.4%
167	Colorectal Neoplasms	8.2%
168	Prader-Willi Syndrome	8.1%
169	Antley-Bixler Syndrome Phenotype	8.1%
170	Acidosis, Lactic	8.1%
171	Calciphylaxis	8.1%
172	Hemosiderosis	8.1%
173	Ketosis	8.1%
174	Ketonuria	8.1%
175	Ketoacidosis	8.1%
176	Ketonemia	8.1%
177	Vascular calcification	8.1%
178	Hyperkeratosis, Epidermolytic	8%
179	Ataxia Telangiectasia	8%
180	Anus, Imperforate	8%
181	Anorectal Malformations	8%
182	Ophthalmia Neonatorum	7.9%
183	HIV-Associated Lipodystrophy Syndrome	7.9%
184	Biliary cirrhosis	7.9%
185	Gastrointestinal Neoplasms	7.8%
186	Liver neoplasms	7.8%
187	Renal Osteodystrophy	7.8%
188	Renal rickets	7.8%
189	Canavan Disease	7.8%
190	Alexander Disease	7.8%
191	Smith-Magenis syndrome	7.6%
192	Bile Duct Neoplasms	7.5%
193	Cri-du-Chat Syndrome	7.5%
194	Down Syndrome	7.5%
195	gallbladder neoplasm	7.5%
196	Intestinal Neoplasms	7.5%
197	Stomach Neoplasms	7.5%
198	Necrobiosis Lipoidica Diabeticorum	7.5%
199	Trisomy 21	7.5%
200	Leukomalacia, Periventricular	7.5%
201	Wernicke Encephalopathy	7.5%
202	Glycogen Storage Disease Type I	7.5%
203	Glycogen Storage Disease Type V	7.5%
204	Adenomatous Polyposis Coli	7.3%
205	Cecal Neoplasms	7.3%
206	Duodenal Neoplasms	7.3%
207	Fragile X Syndrome	7.3%
208	Carcinoma, Pancreatic Ductal	7.2%
209	Hyaline Membrane Disease	7.2%
210	Familial Periodic Paralysis	7.1%
211	Duodenitis	7.1%
212	Ileitis	7.1%
213	Erosive Duodenitis	7.1%
214	Digestive System Neoplasms	7.1%
215	Fetal Diseases	7.1%
216	Renal Aminoacidurias	7%
217	Fanconi Syndrome	7%
218	Pseudohypoaldosteronism	7%
219	Liddle Syndrome	7%
220	Anus Neoplasms	7%
221	Sigmoid Neoplasms	7%
222	Rubinstein-Taybi Syndrome	6.9%
223	Kartagener Syndrome	6.9%
224	Mesenteric vascular insufficiency	6.9%
225	Child Nutrition Disorders	6.8%
226	Hypervitaminosis A	6.8%
227	Infant Nutrition Disorders	6.8%
228	Malnutrition	6.8%
229	Peritoneal Neoplasms	6.8%
230	Mesenteric Vascular Occlusion	6.8%
231	CHARGE Syndrome	6.8%
232	Intestinal Fistula	6.8%
233	Enterocutaneous Fistula	6.8%
234	Dysentery	6.7%
235	Enteritis	6.7%
236	Enterocolitis	6.7%
237	Esophageal and Gastric Varices	6.7%
238	Esophagitis	6.7%
239	Gastritis	6.7%
240	Inflammatory Bowel Diseases	6.7%
241	Cholecystolithiasis	6.7%
242	Ectodermal Dysplasia	6.7%
243	Aplasia Cutis Congenita	6.7%
244	Acidosis, Respiratory	6.7%
245	Adiposis Dolorosa	6.7%
246	Alkalosis, Respiratory	6.7%
247	Esophageal Neoplasms	6.7%
248	Osteoporosis, Postmenopausal	6.7%
249	Rectal Fistula	6.6%
250	Anal Fistula	6.6%
251	Alstrom Syndrome	6.6%
252	insulinoma	6.5%
253	Gastrinoma	6.5%
254	Glucagonoma	6.5%
255	Appendiceal Neoplasms	6.5%
256	Colonic Neoplasms	6.5%
257	Rectal Neoplasms	6.5%
258	Pouchitis	6.4%
259	Gout	6.3%
260	Kearns-Sayre syndrome	6.3%
261	Colitis	6.1%
262	Duodenogastric Reflux	6.1%
263	Peptic Ulcer	6.1%
264	Proctitis	6.1%
265	Choledocholithiasis	6.1%
266	Hypercholesterolemia	6%
267	Hyperlipoproteinemias	6%
268	Hypertriglyceridemia	6%
269	Nail-Patella Syndrome	6%
270	Vipoma	5.9%
271	Marfan Syndrome	5.8%
272	Gastrointestinal Stromal Tumors	5.7%
273	Fatty Liver, Alcoholic	5.7%
274	Hepatitis, Alcoholic	5.7%
275	Liver Cirrhosis, Alcoholic	5.7%
276	Nephrocalcinosis	5.7%
277	Tetany	5.7%
278	Cerebral Amyloid Angiopathy	5.7%
279	Hypokalemic periodic paralysis	5.6%
280	Crohn Disease	5.6%
281	Duodenal Obstruction	5.6%
282	Enterocolitis, Neutropenic	5.6%
283	Necrotizing Enterocolitis	5.6%
284	Cystinuria	5.5%
285	Abnormalities, Drug-Induced	5.5%
286	Bile Duct Diseases	5.5%
287	Cholelithiasis	5.5%
288	Chylous Ascites	5.5%
289	Esophageal Diseases	5.5%
290	Fatty Liver	5.5%
291	Gastroenteritis	5.5%
292	Hepatitis	5.5%
293	Portal Hypertension	5.5%
294	Intestinal Diseases	5.5%
295	Liver Cirrhosis	5.5%
296	Pneumoperitoneum	5.5%
297	Situs Inversus	5.5%
298	Stomach Diseases	5.5%
299	Focal Nodular Hyperplasia	5.5%
300	Hepatic Insufficiency	5.5%
301	Steatohepatitis	5.5%
302	CREST Syndrome	5.4%
303	Anencephaly	5.3%
304	Appendicitis	5.3%
305	Duodenal Ulcer	5.3%
306	Peptic Ulcer Perforation	5.3%
307	Gastric ulcer	5.3%
308	Primary amyloidosis	5%
309	Anemia, Sickle Cell	5%
310	Thalassemia	5%
311	Classical Lissencephalies and Subcortical Band Heterotopias	5%
312	Hepatocellular Adenoma	5%
313	Muscular Dystrophy, Duchenne	5%
314	Polycystic Kidney Diseases	5%
315	Williams Syndrome	5%
316	Arthritis, Gouty	4.9%
317	Primary Ciliary Dyskinesia	4.8%
318	Colonic Pseudo-Obstruction	4.8%
319	Enterocolitis, Pseudomembranous	4.7%
320	pseudomembranous colitis	4.7%
321	Dysentery, Bacillary	4.7%
322	Rett Syndrome	4.7%
323	Eye Abnormalities	4.7%
324	Liver Diseases, Parasitic	4.7%
325	Neoplastic Syndromes, Hereditary	4.7%
326	Cardiovascular Abnormalities	4.7%
327	Maxillofacial Abnormalities	4.6%
328	Dural Arteriovenous Fistula	4.6%
329	Peutz-Jeghers Syndrome	4.6%
330	Dextrocardia	4.6%
331	Hepatic Veno-Occlusive Disease	4.6%
332	Peliosis Hepatis	4.6%
333	Skin Abnormalities	4.6%
334	Lymphatic Abnormalities	4.6%
335	Hepatopulmonary Syndrome	4.6%
336	Congenital Microtia	4.6%
337	Retinal Dysplasia	4.6%
338	Colitis, Ischemic	4.6%
339	Aniridia	4.5%
340	Gastrointestinal Hemorrhage	4.5%
341	Hemoperitoneum	4.5%
342	Hepatomegaly	4.5%
343	Mesenteric Panniculitis	4.5%
344	Multiple Epiphyseal Dysplasia	4.5%
345	Osteochondrodysplasias	4.5%
346	Panniculitis, Peritoneal	4.5%
347	Pelger-Huet Anomaly	4.5%
348	Peritonitis	4.5%
349	Peritoneal Fibrosis	4.5%
350	Myasthenic Syndromes, Congenital	4.5%
351	Encapsulating Peritoneal Sclerosis	4.5%
352	Biliary Fistula	4.5%
353	Gastric Fistula	4.5%
354	Congenital diaphragmatic hernia	4.5%
355	Hepatic Vein Thrombosis	4.5%
356	Liver Abscess	4.5%
357	Budd-Chiari Syndrome	4.5%
358	Tuberculosis, Gastrointestinal	4.5%
359	Liver Abscess, Amebic	4.5%
360	Epidermolysis Bullosa	4.5%
361	Liver Neoplasms, Experimental	4.5%
362	Amyotrophic Lateral Sclerosis	4.5%
363	Turner Syndrome	4.4%
364	Tuberous Sclerosis	4.3%
365	Acrocephalosyndactylia	4.2%
366	Kallmann Syndrome	4.2%
367	Sickle Cell Trait	4.1%
368	Polycystic Kidney, Autosomal Dominant	4.1%
369	Cecal Diseases	4.1%
370	Cholangitis	4.1%
371	Cholecystitis	4.1%
372	Cholestasis	4.1%
373	Colonic Diseases	4.1%
374	Common Bile Duct Diseases	4.1%
375	Deficiency Diseases	4.1%
376	Esophageal Stenosis	4.1%
377	Hepatitis, Chronic	4.1%
378	Ileal Diseases	4.1%
379	Intestinal Obstruction	4.1%
380	Intestinal Perforation	4.1%
381	Jejunal Diseases	4.1%
382	Familial Mediterranean Fever	4.1%
383	Pneumatosis Cystoides Intestinalis	4.1%
384	Prune Belly Syndrome	4.1%
385	Rectal Diseases	4.1%
386	Starvation	4.1%
387	Gastric Dilatation	4.1%
388	Twins, Conjoined	4.1%
389	Liver Failure	4.1%
390	Gastric outlet obstruction	4.1%
391	Cronkhite-Canada Syndrome	4.1%
392	Non-alcoholic Fatty Liver Disease	4.1%
393	Chronic active hepatitis	4.1%
394	Refeeding Syndrome	4.1%
395	Intestinal Polyposis	4.1%
396	Waardenburg Syndrome	4.1%
397	Urogenital Abnormalities	4%
398	Klinefelter Syndrome	4%
399	Dwarfism	4%
400	Wiskott-Aldrich Syndrome	4%
401	Chemical and Drug Induced Liver Injury	4%
402	Microcephaly	3.9%
403	Macrocephaly	3.9%
404	Hepatitis B, Chronic	3.9%
405	Hepatitis C, Chronic	3.9%
406	Fetal Growth Retardation	3.9%
407	Hepatorenal Syndrome	3.9%
408	Muscular Dystrophy	3.9%
409	Osteogenesis Imperfecta	3.9%
410	Fetal Hypoxia	3.9%
411	Fetal Alcohol Spectrum Disorders	3.9%
412	Scimitar Syndrome	3.8%
413	Frontotemporal dementia	3.7%
414	Porencephaly	3.7%
415	Craniosynostosis	3.7%
416	Syndactyly	3.7%
417	Brachycephaly	3.7%
418	Charcot-Marie-Tooth Disease	3.7%
419	Pseudoxanthoma Elasticum	3.7%
420	Myotonic Dystrophy	3.6%
421	Esophageal Perforation	3.5%
422	Hepatitis, Animal	3.5%
423	Hepatitis, Viral, Human	3.5%
424	Intestinal Diseases, Parasitic	3.5%
425	Cleft Palate	3.5%
426	Autoimmune Lymphoproliferative Syndrome	3.4%
427	Anophthalmos	3.4%
428	Barrett Esophagus	3.4%
429	Deglutition Disorders	3.4%
430	Hydranencephaly	3.4%
431	Microphthalmos	3.4%
432	Neural Tube Defects	3.4%
433	Tethered Cord Syndrome	3.4%
434	Iniencephaly	3.4%
435	Craniorachischisis	3.4%
436	Limb Deformities, Congenital	3.4%
437	Exencephaly	3.4%
438	Septo-Optic Dysplasia	3.4%
439	Craniofacial Abnormalities	3.4%
440	Cortical Dysplasia	3.4%
441	Malformations of Cortical Development	3.4%
442	Chorioamnionitis	3.4%
443	Liver Cirrhosis, Experimental	3.4%
444	Gastric Antral Vascular Ectasia	3.4%
445	Cholestasis, Extrahepatic	3.4%
446	Biliary Dyskinesia	3.4%
447	Cholangitis, Sclerosing	3.4%
448	Colonic Diseases, Functional	3.4%
449	Esophageal motility disorders	3.4%
450	Fecal Incontinence	3.4%
451	Fecal Impaction	3.4%
452	Intussusception	3.4%
453	Mallory-Weiss Syndrome	3.4%
454	Megacolon	3.4%
455	Noonan Syndrome	3.4%
456	Pyloric Stenosis	3.4%
457	Liver Failure, Acute	3.4%
458	Acalculous Cholecystitis	3.4%
459	End Stage Liver Disease	3.4%
460	Ileus	3.4%
461	Meconium ileus	3.4%
462	Peptic Ulcer Hemorrhage	3.4%
463	Gastroparesis	3.4%
464	Angioedemas, Hereditary	3.3%
465	Acute Chest Syndrome	3.3%
466	Poland Syndrome	3.3%
467	Jaw Abnormalities	3.2%
468	Hydrops Fetalis	3.2%
469	Basal Cell Nevus Syndrome	3.1%
470	Massive Hepatic Necrosis	3%
471	Esophageal Achalasia	3%
472	Anal Fissure	3%
473	Intestinal Pseudo-Obstruction	3%
474	Irritable Bowel Syndrome	3%
475	Superior Mesenteric Artery Syndrome	3%
476	Emphysematous Cholecystitis	3%
477	Neurogenic Bowel	3%
478	Sphincter of Oddi Dysfunction	3%
479	Anal Ulcer	3%
480	Abnormalities, Radiation-Induced	3%
481	Blepharophimosis	2.9%
482	Laryngostenosis	2.9%
483	Mouth Abnormalities	2.9%
484	Cutis Laxa	2.9%
485	Fascioliasis	2.9%
486	Horseshoe Kidney	2.9%
487	Pectus excavatum	2.9%
488	Echinococcosis, Hepatic	2.9%
489	Klippel-Feil Syndrome	2.9%
490	Melena	2.9%
491	Retinitis Pigmentosa	2.9%
492	Gastroschisis	2.9%
493	Synostosis	2.9%
494	Pigmentary retinopathy	2.9%
495	Acrodermatitis	2.9%
496	Lymphangiectasis, Intestinal	2.9%
497	Porokeratosis	2.9%
498	Gianotti-Crosti Syndrome	2.9%
499	Chemical and Drug Induced Liver Injury, Chronic	2.9%
500	Keratoderma, Palmoplantar	2.9%
501	Micrognathism	2.9%
502	Pierre Robin Syndrome	2.9%
503	Chronic granulomatous disease	2.9%
504	Hematemesis	2.9%
505	Welander Distal Myopathy	2.9%
506	Hemorrhoids	2.8%
507	Autoimmune hepatitis	2.8%
508	Afferent Loop Syndrome	2.8%
509	Amelia	2.8%
510	Arachnodactyly	2.8%
511	Ectopia Cordis	2.8%
512	Ectromelia	2.8%
513	Hemimelia	2.8%
514	Meningomyelocele	2.8%
515	Phocomelia	2.8%
516	Short Bowel Syndrome	2.8%
517	Sirenomelia	2.8%
518	Spina Bifida	2.8%
519	Rectocele	2.8%
520	Polydactyly	2.8%
521	Brachydactyly	2.8%
522	Plagiocephaly	2.8%
523	Lower Extremity Deformities, Congenital	2.8%
524	Upper Extremity Deformities, Congenital	2.8%
525	Single umbilical artery	2.8%
526	Diverticulitis	2.8%
527	Dumping Syndrome	2.8%
528	Rectal Prolapse	2.8%
529	Kwashiorkor	2.7%
530	Magnesium Deficiency	2.7%
531	Potassium Deficiency	2.7%
532	Protein Deficiency	2.7%
533	Avitaminosis	2.7%
534	Retrognathia	2.6%
535	Arthrogryposis	2.6%
536	Choanal Atresia	2.6%
537	Tracheobronchomegaly	2.6%
538	Laryngocele	2.6%
539	Duane Retraction Syndrome	2.6%
540	Hermaphroditism	2.6%
541	Disorders of Sex Development	2.6%
542	Cryptorchidism	2.5%
543	Hypospadias	2.5%
544	Central Nervous System Cysts	2.5%
545	Dandy-Walker Syndrome	2.5%
546	Myotonia Congenita	2.5%
547	Thrombasthenia	2.5%
548	Antithrombin III Deficiency	2.5%
549	Protein C Deficiency	2.5%
550	Pruritus Ani	2.5%
551	Afibrinogenemia	2.5%
552	Dystonia Musculorum Deformans	2.5%
553	Factor VII Deficiency	2.5%
554	Factor X Deficiency	2.5%
555	Factor XII Deficiency	2.5%
556	Hemophilia A	2.5%
557	POEMS Syndrome	2.5%
558	Activated Protein C Resistance	2.5%
559	Factor II deficiency	2.5%
560	Factor VIII Deficiency	2.5%
561	Factor V deficiency	2.5%
562	Factor XI Deficiency	2.5%
563	Hypoprothrombinemias	2.5%
564	Dermal Sinus	2.5%
565	Spina Bifida Cystica	2.5%
566	Spina Bifida Occulta	2.5%
567	Lissencephaly	2.5%
568	Polymicrogyria	2.5%
569	Pachygyria	2.5%
570	Schizencephaly	2.5%
571	Periventricular Nodular Heterotopia	2.5%
572	Hepatitis, Viral, Animal	2.5%
573	Lafora Disease	2.5%
574	Unverricht-Lundborg Syndrome	2.5%
575	Anemia, Diamond-Blackfan	2.5%
576	Obesity	2.5%
577	Hyperandrogenism	2.4%
578	Giardiasis	2.4%
579	Hepatitis E	2.4%
580	Hepatitis B	2.4%
581	Hepatitis C	2.4%
582	Prognathism	2.4%
583	Diverticulum	2.4%
584	Hepatitis A	2.4%
585	Diverticulosis	2.4%
586	Aortic coarctation	2.4%
587	Cor Triatriatum	2.4%
588	Coronary Vessel Anomalies	2.4%
589	Dental Enamel Hypoplasia	2.4%
590	Patent ductus arteriosus	2.4%
591	Ebstein Anomaly	2.4%
592	Heart Septal Defects	2.4%
593	Hypodontia	2.4%
594	Macrostomia	2.4%
595	Meningocele	2.4%
596	Microstomia	2.4%
597	Tetralogy of Fallot	2.4%
598	Transposition of Great Vessels	2.4%
599	Hypoplastic Left Heart Syndrome	2.4%
600	May-Thurner Syndrome	2.4%
601	Encephalocele	2.4%
602	Laryngopharyngeal Reflux	2.4%
603	Craniofacial Dysostosis	2.4%
604	Papillon-Lefevre Disease	2.4%
605	Wolff-Parkinson-White Syndrome	2.4%
606	Multiple Endocrine Neoplasia	2.3%
607	Laryngomalacia	2.3%
608	Pectus carinatum	2.3%
609	Bladder Exstrophy	2.2%
610	Congenital Hypothyroidism	2.2%
611	Epispadias	2.2%
612	Dermatitis, Atopic	2.2%
613	Multicystic Dysplastic Kidney	2.2%
614	Aortopulmonary Septal Defect	2.1%
615	Double Outlet Right Ventricle	2.1%
616	Endocardial Cushion Defects	2.1%
617	Myocardial bridging	2.1%
618	Aorticopulmonary Septal Defect	2.1%
619	Long QT Syndrome	2.1%
620	Platybasia	2.1%
621	Tricuspid Atresia	2.1%
622	Arrhythmogenic Right Ventricular Dysplasia	2.1%
623	Gonadal Dysgenesis	2.1%
624	Bronchomalacia	2.1%
625	Adrenogenital Syndrome	2.1%
626	Tracheomalacia	2.1%
627	Ovotesticular Disorders of Sex Development	2.1%
628	Behcet Syndrome	2%
629	Ascorbic Acid Deficiency	2%
630	Vitamin A Deficiency	2%
631	Vitamin D Deficiency	2%
632	Vitamin E Deficiency	2%
633	Marasmus	2%
634	Truncus Arteriosus, Persistent	2%
635	Goldenhar Syndrome	2%
636	Denys-Drash Syndrome	1.9%
637	Obesity, Abdominal	1.9%
638	Mandibulofacial Dysostosis	1.9%
639	Romano-Ward Syndrome	1.9%
640	Multiple Endocrine Neoplasia Type 1	1.9%
641	Huntington Disease	1.8%
642	Talipes	1.8%
643	Congenital clubfoot	1.7%
644	Vertical Talus	1.7%
645	Cryptosporidiosis	1.7%
646	Folic Acid Deficiency	1.7%
647	Pellagra	1.7%
648	Thiamine Deficiency	1.7%
649	Vitamin B 12 Deficiency	1.7%
650	Vitamin B 6 Deficiency	1.7%
651	Pyridoxine Deficiency	1.7%
652	Nephroblastoma	1.7%
653	Pediatric Obesity	1.6%
654	Rift Valley Fever	1.5%
655	Beriberi	1.5%
656	Arteriovenous fistula	1.5%
657	Vitamin K Deficiency	1.4%
658	Anemia, Pernicious	1.2%
659	Scurvy	1.2%
660	Subacute Combined Degeneration	0.8%

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