MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Deformity

(UMLS:C0302142)

UMLS ID:: C0302142
MeSH ID:: D000013

Classification:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131

Synonym(s)

Deformity

Anatomic Abnormality

Anatomical Abnormality

Anatomical deformity

Congenital or Acquired Anatomic Abnormality

Congenital or Acquired Anatomical Abnormality

MALFORMATION

deformity

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Metoclopramide	FAERS: 2327	US FAERS
2	Valproic Acid	FAERS: 595	US FAERS
3	Zoledronic Acid	FAERS: 256	US FAERS
4	Docetaxel	FAERS: 100	US FAERS
5	Clopidogrel	FAERS: 84	US FAERS
6	Pamidronate	FAERS: 67	US FAERS
7	Metoclopramide	FAERS: 63	US FAERS
8	Carbamazepine	FAERS: 59	US FAERS
9	Ondansetron	FAERS: 40 Canada Vigilance: 1	Canada Vigilance US FAERS
10	Norgestrel	FAERS: 31	US FAERS
11	Gadolinium DTPA	FAERS: 23	US FAERS
12	Rosiglitazone	FAERS: 19	US FAERS
13	Digoxin	FAERS: 16	US FAERS
14	tofacitinib	FAERS: 15	US FAERS
15	Isotretinoin	FAERS: 12	US FAERS
16	Paroxetine	FAERS: 12	US FAERS
17	Triamcinolone Acetonide	FAERS: 11	US FAERS
18	Aprotinin	FAERS: 10	US FAERS
19	Levofloxacin	FAERS: 10	US FAERS
20	Alendronate	FAERS: 8	US FAERS
21	Gabapentin	FAERS: 7	US FAERS
22	Glatiramer Acetate	FAERS: 7 Canada Vigilance: 1	Canada Vigilance US FAERS
23	Methotrexate	FAERS: 7	US FAERS
24	Risperidone	FAERS: 7	US FAERS
25	Teriparatide	FAERS: 7	US FAERS
26	Testosterone	FAERS: 7	US FAERS
27	Dexamethasone	FAERS: 6	US FAERS
28	Finasteride	FAERS: 6	US FAERS
29	Ciprofloxacin	FAERS: 5 Canada Vigilance: 3	Canada Vigilance US FAERS
30	NuvaRing	FAERS: 5	US FAERS
31	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 4	US FAERS
32	Valproic Acid	FAERS: 4	US FAERS
33	Celecoxib	FAERS: 3	US FAERS
34	Fentanyl	FAERS: 3	US FAERS
35	Ibuprofen	FAERS: 3	US FAERS
36	Mycophenolic Acid	FAERS: 3	US FAERS
37	Prednisone	FAERS: 3	US FAERS
38	Valproic Acid	FAERS: 3	US FAERS
39	pimecrolimus	FAERS: 3	US FAERS
40	3-ingenyl angelate	FAERS: 2	US FAERS
41	Acetaminophen	FAERS: 2	US FAERS
42	Amlodipine	FAERS: 2	US FAERS
43	Aripiprazole	FAERS: 2	US FAERS
44	Ciprofloxacin	FAERS: 2	US FAERS
45	Clonidine	FAERS: 2	US FAERS
46	Deoxycholic Acid	FAERS: 2	US FAERS
47	Fingolimod Hydrochloride	FAERS: 2	US FAERS
48	Fluorouracil	FAERS: 2	US FAERS
49	Ibandronic Acid	FAERS: 2	US FAERS
50	Methotrexate	FAERS: 2	US FAERS
51	Octreotide	FAERS: 2	US FAERS
52	Pamidronate	FAERS: 2	US FAERS
53	Phenytoin	FAERS: 2	US FAERS
54	Pramipexole	FAERS: 2	US FAERS
55	Ribavirin	FAERS: 2	US FAERS
56	Rosiglitazone	FAERS: 2	US FAERS
57	Sertraline	FAERS: 2 Canada Vigilance: 1	Canada Vigilance US FAERS
58	Sitagliptin Phosphate	FAERS: 2	US FAERS
59	Valsartan	FAERS: 2	US FAERS
60	carbidopa, levodopa drug combination	FAERS: 2	US FAERS
61	reviparin	FAERS: 2	US FAERS
62	sofosbuvir-velpatasvir drug combination	FAERS: 2	US FAERS
63	tegaserod	FAERS: 2	US FAERS
64	ziprasidone	FAERS: 2	US FAERS
65	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1	US FAERS
66	Adapalene	FAERS: 1	US FAERS
67	Advil PM	FAERS: 1	US FAERS
68	Allopurinol	FAERS: 1	US FAERS
69	Alprostadil	FAERS: 1	US FAERS
70	Amoxicillin	FAERS: 1	US FAERS
71	Azathioprine	FAERS: 1	US FAERS
72	Azithromycin	FAERS: 1	US FAERS
73	Baclofen	FAERS: 1	US FAERS
74	Bimatoprost	FAERS: 1	US FAERS
75	Capecitabine	FAERS: 1	US FAERS
76	Clarithromycin	FAERS: 1	US FAERS
77	Clindamycin	FAERS: 1	US FAERS
78	Clobetasol	FAERS: 1	US FAERS
79	Dextromethorphan	FAERS: 1	US FAERS
80	Diphenhydramine	FAERS: 1	US FAERS
81	Doxycycline	FAERS: 1	US FAERS
82	Enfuvirtide	FAERS: 1	US FAERS
83	Febuxostat	FAERS: 1	US FAERS
84	Fluticasone	FAERS: 1	US FAERS
85	Gadolinium	FAERS: 1	US FAERS
86	Haloperidol	FAERS: 1	US FAERS
87	HhAntag691	FAERS: 1	US FAERS
88	Hydroxychloroquine	FAERS: 1	US FAERS
89	Ibandronic Acid	FAERS: 1	US FAERS
90	Imatinib Mesylate	FAERS: 1	US FAERS
91	Lamotrigine	FAERS: 1	US FAERS
92	Lenalidomide	FAERS: 1	US FAERS
93	Levetiracetam	FAERS: 1	US FAERS
94	Medroxyprogesterone Acetate	FAERS: 1	US FAERS
95	Menthol	FAERS: 1	US FAERS
96	Methimazole	FAERS: 1	US FAERS
97	Methylphenidate	FAERS: 1	US FAERS
98	Methylprednisolone Acetate	FAERS: 1	US FAERS
99	Miconazole	FAERS: 1	US FAERS
100	Minocycline	FAERS: 1	US FAERS
101	Minoxidil	FAERS: 1	US FAERS
102	Mometasone Furoate	FAERS: 1	US FAERS
103	Morphine	FAERS: 1	US FAERS
104	Mupirocin	FAERS: 1	US FAERS
105	Naproxen	FAERS: 1	US FAERS
106	Naproxen	FAERS: 1	US FAERS
107	Octreotide	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
108	Olanzapine	FAERS: 1	US FAERS
109	Promethazine	FAERS: 1	US FAERS
110	Propranolol	FAERS: 1	US FAERS
111	Quetiapine Fumarate	FAERS: 1	US FAERS
112	Raloxifene Hydrochloride	FAERS: 1	US FAERS
113	Risedronic Acid	FAERS: 1	US FAERS
114	Rivaroxaban	FAERS: 1	US FAERS
115	Rocuronium	FAERS: 1	US FAERS
116	Ruxolitinib phosphate	FAERS: 1	US FAERS
117	Sildenafil Citrate	FAERS: 1	US FAERS
118	Spironolactone	FAERS: 1	US FAERS
119	Stavudine	FAERS: 1	US FAERS
120	Sulfamethoxazole	FAERS: 1	US FAERS
121	Tadalafil	FAERS: 1	US FAERS
122	Tadenan	FAERS: 1	US FAERS
123	Tamsulosin	FAERS: 1	US FAERS
124	Terbinafine	FAERS: 1	US FAERS
125	Thyroxine	FAERS: 1	US FAERS
126	Thyroxine	FAERS: 1	US FAERS
127	Tiotropium Bromide	FAERS: 1	US FAERS
128	Tri-Luma	FAERS: 1	US FAERS
129	Vancomycin	FAERS: 1	US FAERS
130	Venlafaxine Hydrochloride	FAERS: 1	US FAERS
131	Vitamin B 12	FAERS: 1	US FAERS
132	Zolpidem	FAERS: 1	US FAERS
133	ambrisentan	FAERS: 1	US FAERS
134	ciclesonide	FAERS: 1	US FAERS
135	fluphenazine depot	FAERS: 1	US FAERS
136	gadodiamide	FAERS: 1	US FAERS
137	haloperidol decanoate	FAERS: 1	US FAERS
138	histrelin	FAERS: 1	US FAERS
139	prednisolone acetate	FAERS: 1	US FAERS
140	teriflunomide	FAERS: 1	US FAERS
141	testosterone undecanoate	FAERS: 1	US FAERS
142	tizanidine	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Genetic Diseases, Inborn	33.3%
2	Abdominal Cramps	23.1%
3	Amniotic Band Syndrome	23.1%
4	Asphyxia Neonatorum	23.1%
5	Infant, Premature, Diseases	23.1%
6	Infantile Colic	23.1%
7	Fetal Diseases	21.1%
8	Familial Mediterranean Fever	18.5%
9	Cystic Fibrosis	17.6%
10	Neoplastic Syndromes, Hereditary	15.8%
11	Rett Syndrome	15.3%
12	Fragile X Syndrome	15%
13	Anemia, Neonatal	14.6%
14	Multiple Epiphyseal Dysplasia	14.6%
15	Osteochondrodysplasias	14.6%
16	Pelger-Huet Anomaly	14.6%
17	Persistent Fetal Circulation Syndrome	14.6%
18	Werner Syndrome	14.6%
19	Myasthenic Syndromes, Congenital	14.6%
20	Umbilical hernia	14.4%
21	Meconium Aspiration Syndrome	14.3%
22	Anemia, Sickle Cell	13.7%
23	Thalassemia	13.7%
24	Muscular Dystrophy, Duchenne	13.7%
25	Ichthyosis, X-Linked	13%
26	Mucopolysaccharidosis II	12.8%
27	Albinism	12.3%
28	Paralysis, Obstetric	12.2%
29	Retinopathy of Prematurity	12.2%
30	Sickle Cell Trait	12.1%
31	Amino Acid Metabolism, Inborn Errors	11.9%
32	Carbohydrate Metabolism, Inborn Errors	11.9%
33	Metal Metabolism, Inborn Errors	11.9%
34	Progeria	11.9%
35	Lysosomal Storage Diseases	11.9%
36	Cytochrome-c Oxidase Deficiency	11.9%
37	Peroxisomal Disorders	11.9%
38	Bronchopulmonary Dysplasia	11.8%
39	Dwarfism	11.3%
40	Neonatal Abstinence Syndrome	11.1%
41	Menkes Kinky Hair Syndrome	10.8%
42	Fetal Growth Retardation	10.7%
43	CHARGE Syndrome	10.7%
44	Muscular Dystrophy	10.6%
45	Osteogenesis Imperfecta	10.6%
46	Fetal Hypoxia	10.6%
47	Congenital nystagmus	10.6%
48	Fetal Alcohol Spectrum Disorders	10.6%
49	Toxoplasmosis, Congenital	10.5%
50	Alkaptonuria	10.5%
51	Glycogen Storage Disease	10.5%
52	Hypophosphatasia	10.5%
53	Propionic acidemia	10.5%
54	Dihydropyrimidine Dehydrogenase Deficiency	10.5%
55	Cystinosis	10.5%
56	Syphilis, Congenital	10.4%
57	Neuronal Ceroid-Lipofuscinoses	10.4%
58	Aicardi's syndrome	10%
59	Glycogen Storage Disease Type I	9.8%
60	Glycogen Storage Disease Type V	9.8%
61	Cockayne Syndrome	9.8%
62	Wiskott-Aldrich Syndrome	9.7%
63	Sjogren-Larsson Syndrome	9.5%
64	Mucopolysaccharidosis III	9.4%
65	Alstrom Syndrome	9.3%
66	Glycogen storage disease type II	9.2%
67	Respiratory Distress Syndrome, Newborn	9.1%
68	Cutis Laxa	8.9%
69	Retinitis Pigmentosa	8.8%
70	Pigmentary retinopathy	8.8%
71	Acute Chest Syndrome	8.8%
72	Beckwith-Wiedemann Syndrome	8.8%
73	Porokeratosis	8.8%
74	Wolf-Hirschhorn Syndrome	8.8%
75	Keratoderma, Palmoplantar	8.8%
76	Chronic granulomatous disease	8.7%
77	Fabry Disease	8.6%
78	Smith-Lemli-Opitz Syndrome	8.6%
79	Welander Distal Myopathy	8.6%
80	Nail-Patella Syndrome	8.6%
81	Autoimmune Lymphoproliferative Syndrome	8.6%
82	Galactosemias	8.6%
83	Urea Cycle Disorders, Inborn	8.6%
84	Tyrosinemias	8.6%
85	Adrenoleukodystrophy	8.5%
86	Hyperkeratosis, Epidermolytic	8.5%
87	Xeroderma	8.5%
88	Mobius Syndrome	8.5%
89	Congenital Hyperinsulinism	8.5%
90	Myotonic Dystrophy	8.4%
91	Chorioamnionitis	8.4%
92	Angioedemas, Hereditary	8.3%
93	Gaucher Disease	8%
94	Amyloid Neuropathies, Familial	7.9%
95	Hydrops Fetalis	7.8%
96	Hyaline Membrane Disease	7.8%
97	Hepatolenticular Degeneration	7.8%
98	Tay-Sachs Disease	7.8%
99	Hypolipoproteinemias	7.7%
100	Papillon-Lefevre Disease	7.7%
101	Hyperlipidemia, Familial Combined	7.7%
102	Hyperlipoproteinemia Type III	7.6%
103	Primary Ciliary Dyskinesia	7.5%
104	Optic Atrophy, Hereditary, Leber	7.5%
105	Hyperphosphaturia	7.5%
106	Refsum Disease	7.4%
107	Homocystinuria	7.3%
108	Leigh Disease	7.2%
109	Hypoalphalipoproteinemias	7.2%
110	Duane Retraction Syndrome	7.1%
111	Niemann-Pick Disease, Type C	7.1%
112	Porphyrias, Hepatic	7%
113	Smith-Magenis syndrome	7%
114	Carbamoyl-Phosphate Synthase I Deficiency Disease	7%
115	Tuberous Sclerosis	6.9%
116	Peutz-Jeghers Syndrome	6.9%
117	Cri-du-Chat Syndrome	6.9%
118	Down Syndrome	6.9%
119	Myotonia Congenita	6.9%
120	Thrombasthenia	6.9%
121	Antithrombin III Deficiency	6.9%
122	Protein C Deficiency	6.9%
123	Brain Diseases, Metabolic, Inborn	6.9%
124	Trisomy 21	6.9%
125	Afibrinogenemia	6.8%
126	Dystonia Musculorum Deformans	6.8%
127	Factor VII Deficiency	6.8%
128	Factor X Deficiency	6.8%
129	Factor XII Deficiency	6.8%
130	Hemophilia A	6.8%
131	Leukomalacia, Periventricular	6.8%
132	Activated Protein C Resistance	6.8%
133	Factor II deficiency	6.8%
134	Factor VIII Deficiency	6.8%
135	Factor V deficiency	6.8%
136	Factor XI Deficiency	6.8%
137	Hypoprothrombinemias	6.8%
138	Polycystic Kidney Diseases	6.8%
139	Williams Syndrome	6.8%
140	Canavan Disease	6.8%
141	Alexander Disease	6.8%
142	Fanconi Anemia	6.8%
143	Nesidioblastosis	6.8%
144	Lafora Disease	6.8%
145	Unverricht-Lundborg Syndrome	6.8%
146	Anemia, Diamond-Blackfan	6.8%
147	Familial Periodic Paralysis	6.2%
148	Lactose Intolerance	6.1%
149	Variegate Porphyria	6.1%
150	Acute intermittent porphyria	6.1%
151	Porphyria Cutanea Tarda	6.1%
152	Hyperhomocysteinemia	6.1%
153	Renal Aminoacidurias	6.1%
154	Fanconi Syndrome	6.1%
155	Pseudohypoaldosteronism	6.1%
156	Liddle Syndrome	6.1%
157	Polycystic Kidney, Autosomal Dominant	6%
158	Hyperlipoproteinemia Type IV	6%
159	Hyperlipoproteinemia Type V	6%
160	Multiple Endocrine Neoplasia	6%
161	Retinal Dysplasia	6%
162	Aniridia	5.9%
163	Kallmann Syndrome	5.8%
164	Congenital Hypothyroidism	5.8%
165	Ophthalmia Neonatorum	5.8%
166	Dermatitis, Atopic	5.7%
167	Ectodermal Dysplasia	5.7%
168	Epidermolysis Bullosa	5.7%
169	Aplasia Cutis Congenita	5.7%
170	Hypokalemic periodic paralysis	5.7%
171	Prader-Willi Syndrome	5.7%
172	Cystinuria	5.7%
173	Kartagener Syndrome	5.5%
174	Zellweger Syndrome	5.5%
175	Marfan Syndrome	5.2%
176	Ataxia Telangiectasia	5.2%
177	Gout	5.2%
178	Multiple Endocrine Neoplasia Type 1	5.1%
179	Pseudohypoparathyroidism	5.1%
180	Charcot-Marie-Tooth Disease	5%
181	Friedreich Ataxia	5%
182	Antley-Bixler Syndrome Phenotype	5%
183	Renal tubular acidosis	5%
184	Classical Lissencephalies and Subcortical Band Heterotopias	5%
185	Kernicterus	4.9%
186	Behcet Syndrome	4.9%
187	Arthritis, Gouty	4.7%
188	Pseudoxanthoma Elasticum	4.3%
189	Holoprosencephaly	4.2%
190	Familial Hypophosphatemic Rickets	4.2%
191	Rubinstein-Taybi Syndrome	4.2%
192	Huntington Disease	4.2%
193	Xeroderma Pigmentosum	3.8%
194	Nephroblastoma	3.7%
195	Glycosuria, Renal	3.7%
196	Klinefelter Syndrome	3.5%
197	Basal Cell Nevus Syndrome	3.4%
198	Adenomatous Polyposis Coli	3.3%
199	MELAS Syndrome	3%
200	Denys-Drash Syndrome	2.3%
201	Turner Syndrome	2%

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