MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Subacute Sclerosing Panencephalitis

(UMLS:C0038522)

Definition:: A rare, slowly progressive encephalitis caused by chronic infection with the MEASLES VIRUS. The condition occurs primarily in children and young adults, approximately 2-8 years after the initial infection. A gradual decline in intellectual abilities and behavioral alterations are followed by progressive MYOCLONUS; MUSCLE SPASTICITY; SEIZURES; DEMENTIA; autonomic dysfunction; and ATAXIA. DEATH usually occurs 1-3 years after disease onset. Pathologic features include perivascular cuffing, eosinophilic cytoplasmic inclusions, neurophagia, and fibrous gliosis. It is caused by the SSPE virus, which is a defective variant of MEASLES VIRUS. (From Adams et al., Principles of Neurology, 6th ed, pp767-8)
UMLS ID:: C0038522
MeSH ID:: D013344

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.182.525.600|C02.290.700|C02.782.580.600.500.500.800|C02.839.862

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.430.520.750.600|C10.228.228.245.340.600|C10.228.228.399.750.600

Synonym(s)

Subacute Sclerosing Panencephalitis

Bodechtel-Guttman

DEMENTIA, DECEREBRATE

Dawson

Dawson's encephalitis

Dawson's inclusion body encephalitis

Dawson; encephalitis

Immunosuppressive measles encephalitis

MIBE - Measles inclusion body encephalitis

10.

Measles inclusion body encephalitis

11.

SSPE

12.

SSPE (subacute sclerosing panencephalitis)

13.

SSPE - Subacute sclerosing panencephalitis

14.

SUBACUTE SCLEROSING PANENCEPHALITIS

15.

Subacute sclerosing panencephalitis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methylphenidate	FAERS: 1		US FAERS
2	Ribavirin		8031027 9497070	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Leukoencephalopathy, Progressive Multifocal	60.7%
2	West Nile Fever	45.1%
3	Meningoencephalitis	38.3%
4	Encephalomyelitis	30.1%
5	Pseudorabies	28.6%
6	Epidural Abscess	26.4%
7	Rift Valley Fever	25.1%
8	Chronic Fatigue Syndrome	24%
9	Cerebral Ventriculitis	23.5%
10	Myelitis	23.3%
11	Brain Abscess	21.9%
12	Dengue Fever	21.8%
13	Yellow Fever	21.8%
14	Warts	21.5%
15	Acquired Immunodeficiency Syndrome	21.1%
16	AIDS related complex	21.1%
17	Hemorrhagic Fever, Crimean	21.1%
18	Hepatitis E	20.4%
19	Prion Diseases	20.3%
20	Subdural Effusion	20.3%
21	Poliomyelitis	20.2%
22	Subacute Sclerosing Panencephalitis	19.9%
23	Limbic Encephalitis	19.6%
24	Simian Acquired Immunodeficiency Syndrome	19.6%
25	Condylomata Acuminata	18.9%
26	Pneumocephalus	18.5%
27	Ocular Motility Disorders	18.1%
28	Cyclophoria	18.1%
29	Phlebotomus Fever	18.1%
30	Multiple System Atrophy	18.1%
31	Arbovirus Infections	17.9%
32	Lupus Vasculitis, Central Nervous System	17.7%
33	Hemorrhagic Fever, American	16.7%
34	Lassa Fever	16.7%
35	Meningitis	16.5%
36	Movement Disorders	16.5%
37	Pachymeningitis	16.5%
38	Spinal Cord Diseases	16.5%
39	Epstein-Barr Virus Infections	16.5%
40	Murine Acquired Immunodeficiency Syndrome	16.4%
41	Hepatitis C	16.3%
42	Hepatitis, Viral, Human	15.9%
43	Zika Virus Infection	15.8%
44	Viremia	15.8%
45	Central Nervous System Fungal Infections	15.4%
46	Meningitis, Bacterial	15.3%
47	Meningitis, Fungal	15.3%
48	Epidermodysplasia Verruciformis	15.1%
49	Lewy Body Disease	15.1%
50	Hepatitis B	14.8%
51	Molluscum Contagiosum	14.8%
52	Stiff-Person Syndrome	14.7%
53	Dandy-Walker Syndrome	14.7%
54	Opportunistic Infections	14.6%
55	Orthomyxoviridae Infections	14.4%
56	Picornaviridae Infections	14.4%
57	Reoviridae Infections	14.4%
58	Retroviridae Infections	14.4%
59	Hemorrhagic Fever with Renal Syndrome	14.4%
60	Parkinsonian Disorders	14.4%
61	Hepatitis, Viral, Animal	14.3%
62	Pneumonia, Viral	14.2%
63	Dementia, Vascular	14.2%
64	Hepatitis A	14.2%
65	Central Nervous System Bacterial Infections	14%
66	Creutzfeldt-Jakob disease	14%
67	Toxoplasmosis, Cerebral	13.7%
68	Erythema Infectiosum	13.4%
69	Subacute Combined Degeneration	13.4%
70	Sexually Transmitted Diseases	13.1%
71	Rhabdoviridae Infections	13.1%
72	Nipah Virus Infection	13%
73	Myelitis, Transverse	13%
74	Progressive supranuclear palsy	12.9%
75	Herpes Zoster Ophthalmicus	12.7%
76	Akinetic Mutism	12.7%
77	Anoxic Encephalopathy	12.7%
78	Basal Ganglia Diseases	12.7%
79	Brain Damage, Chronic	12.7%
80	Cerebellar Diseases	12.7%
81	Encephalomalacia	12.7%
82	Epilepsy	12.7%
83	Hydrocephalus	12.7%
84	Congenital Hydrocephalus	12.7%
85	Hypothalamic Diseases	12.7%
86	Thalamic Diseases	12.7%
87	Intracranial Hypertension	12.7%
88	Aura	12.7%
89	Leukoencephalopathy	12.7%
90	Neuroaxonal Dystrophies	12.7%
91	Headache Disorders	12.7%
92	Intracranial Hypotension	12.7%
93	Brain Edema	12.7%
94	Brain Hypoxia	12.7%
95	Aqueductal Stenosis	12.7%
96	Brain Injuries	12.6%
97	Brain Neoplasms	12.5%
98	AIDS Dementia Complex	12.5%
99	Parkinson Disease	12.3%
100	Tuberculosis, Meningeal	12.3%
101	Keratitis, Herpetic	12.2%
102	Cytomegalovirus Retinitis	12.2%
103	Exanthema Subitum	12.2%
104	Spinal Muscular Atrophy	12%
105	Progressive Muscular Atrophy	12%
106	Huntington Disease	12%
107	Amyotrophic Lateral Sclerosis	12%
108	Spinal Cord Injuries	11.9%
109	Epilepsy, Post-Traumatic	11.8%
110	Basal Ganglia Cerebrovascular Disease	11.7%
111	Asterixis	11.6%
112	Ballismus	11.6%
113	HIV Infections	11.6%
114	Marchiafava-Bignami Disease	11.4%
115	Brain Diseases, Metabolic	11.4%
116	Cerebrovascular Disorders	11.4%
117	Cerebrovascular Insufficiency	11.4%
118	Dementia	11.4%
119	Dystonia Musculorum Deformans	11.3%
120	Brain Diseases	11.2%
121	Meige Syndrome	11.1%
122	AIDS-Related Opportunistic Infections	11.1%
123	Herpesviridae Infections	10.9%
124	Polyomavirus Infections	10.9%
125	Brain Death	10.8%
126	Cranial nerve diseases	10.7%
127	Demyelinating Diseases	10.7%
128	Demyelination	10.7%
129	Neuromuscular Diseases	10.7%
130	Chronobiology Disorders	10.7%
131	Eczema Herpeticum	10.7%
132	Scrapie	10.6%
133	Leukomalacia, Periventricular	10.6%
134	Hepatolenticular Degeneration	10.6%
135	Striatonigral Degeneration	10.6%
136	Posterior Leukoencephalopathy Syndrome	10.5%
137	Posterior reversible encephalopathy syndrome	10.5%
138	Amblyopia	10.5%
139	Hepatitis C, Chronic	10.4%
140	Neuroleptic Malignant Syndrome	10.3%
141	Myelinolysis, Central Pontine	10.3%
142	Restless Legs Syndrome	10.3%
143	Ophthalmoplegic Migraine	10.1%
144	Herpangina	10%
145	Motor Neuron Disease	9.9%
146	Genital Herpes	9.8%
147	Akathisia, Drug-Induced	9.7%
148	Herpes Labialis	9.7%
149	Shy-Drager Syndrome	9.7%
150	Trauma, Nervous System	9.7%
151	Hepatitis B, Chronic	9.7%
152	Opsoclonus-Myoclonus Syndrome	9.6%
153	Spinal Cord Neoplasms	9.6%
154	Nervous System Neoplasms	9.5%
155	Neurologic Manifestations	9.5%
156	Neurotoxicity Syndromes	9.5%
157	Vascular Headaches	9.5%
158	Hypoxia-Ischemia, Brain	9.5%
159	Cerebellar Neoplasms	9.4%
160	Enterovirus Infections	9.4%
161	Flavivirus Infections	9.4%
162	Cardiovirus Infections	9.4%
163	Polyradiculoneuropathy	9.3%
164	Polyradiculoneuritis	9.3%
165	Respiratory Syncytial Virus Infections	9.3%
166	HIV Seropositivity	9.2%
167	Leukoencephalitis, Acute Hemorrhagic	9.2%
168	Amnesia, Transient Global	9.1%
169	Tuberculosis, Central Nervous System	9%
170	Arachnoiditis	9%
171	Aseptic Meningitis	9%
172	Syringomyelia	9%
173	Essential Tremor	9%
174	Familial Tremor	9%
175	Pneumorrhachis	9%
176	Writer's Cramp	9%
177	Hydrophobia	8.9%
178	MPTP Poisoning	8.8%
179	Burkitt Lymphoma	8.8%
180	Superinfection	8.8%
181	Sleep Wake Disorders	8.7%
182	Miller Fisher Syndrome	8.7%
183	Meningitis, Cryptococcal	8.6%
184	Meningitis, Listeria	8.6%
185	Meningitis, Haemophilus	8.6%
186	Meningitis, Pneumococcal	8.6%
187	Vasculitis, Central Nervous System	8.6%
188	Foot-and-Mouth Disease	8.5%
189	Dyskinesia, Drug-Induced	8.5%
190	Common Cold	8.4%
191	Influenza	8.4%
192	Catarrh	8.4%
193	Mumps	8.3%
194	Presenile dementia	8.2%
195	Senile dementia	8.2%
196	Myoclonic Epilepsy	8.2%
197	Epilepsy, Temporal Lobe	8.2%
198	Epilepsy, Rolandic	8.2%
199	Benign Rolandic Epilepsy	8.2%
200	Neuroaspergillosis	8.2%
201	Conus Medullaris Syndrome	8%
202	Spinal Cord Vascular Diseases	8%
203	Brain Hemorrhage, Traumatic	8%
204	Bell Palsy	7.7%
205	Friedreich Ataxia	7.7%
206	Encephalomyelitis, Acute Disseminated	7.7%
207	HIV Wasting Syndrome	7.7%
208	AIDS-Associated Nephropathy	7.7%
209	Basal Ganglia Hemorrhage	7.6%
210	Autonomic Dysreflexia	7.6%
211	Complex Regional Pain Syndromes	7.6%
212	Cytomegalovirus Infections	7.5%
213	Smallpox	7.5%
214	Varicella Zoster Virus Infection	7.5%
215	Carotid Artery Injuries	7.5%
216	Paraneoplastic Cerebellar Degeneration	7.5%
217	Neurosyphilis	7.4%
218	Canavan Disease	7.3%
219	Alexander Disease	7.3%
220	Vesicular Stomatitis	7.3%
221	Cerebral Palsy	7.3%
222	Epilepsies, Partial	7.3%
223	Epilepsy, Generalized	7.3%
224	Pseudotumor Cerebri	7.3%
225	Hypertensive Encephalopathy	7.3%
226	Simple Partial Seizures	7.3%
227	Epilepsy, Reflex	7.3%
228	Headache Disorders, Primary	7.3%
229	Headache Disorders, Secondary	7.3%
230	Medication overuse headache	7.3%
231	Brain Injuries, Diffuse	7.2%
232	Traumatic Brain Injury	7.2%
233	Cerebellar Ataxia	7.2%
234	Supratentorial Neoplasms	7.2%
235	Pituitary Adenoma	7.1%
236	Pituitary Neoplasms	7.1%
237	Lambert-Eaton Myasthenic Syndrome	7.1%
238	HIV-Associated Lipodystrophy Syndrome	7%
239	Coxsackievirus Infections	6.9%
240	Rubella	6.9%
241	Coronavirus Infections	6.9%
242	Peripheral Nerve Injuries	6.9%
243	Myasthenia Gravis	6.8%
244	Pituitary Apoplexy	6.7%
245	Lyme Neuroborreliosis	6.7%
246	Guillain-Barre Syndrome	6.7%
247	Persistent Vegetative State	6.7%
248	Brain Infarction	6.7%
249	Pituitary Diseases	6.6%
250	Central Cord Syndrome	6.6%
251	Paramyxoviridae Infections	6.6%
252	Chorea	6.6%
253	Carotid Artery Diseases	6.5%
254	Brain Ischemia	6.5%
255	Cerebrovascular accident	6.5%
256	Kluver-Bucy Syndrome	6.5%
257	Vasospasm, Intracranial	6.5%
258	Intracranial Arterial Diseases	6.5%
259	Sleep Disorders, Circadian Rhythm	6.3%
260	Encephalitis	6.2%
261	Botulism	6.2%
262	Central Nervous System Cysts	6.2%
263	Porcine Reproductive and Respiratory Syndrome	6.2%
264	HTLV-I Infections	6.1%
265	Mitochondrial Encephalomyopathies	6%
266	Neuromyelitis Optica	5.9%
267	Lafora Disease	5.9%
268	Unverricht-Lundborg Syndrome	5.9%
269	Herpes Zoster Oticus	5.9%
270	Chickenpox	5.9%
271	Reye Syndrome	5.8%
272	Intracranial Embolism and Thrombosis	5.8%
273	Hepatic Encephalopathy	5.8%
274	Juvenile Myoclonic Epilepsy	5.8%
275	Myoclonic Epilepsies, Progressive	5.8%
276	Adrenoleukodystrophy	5.7%
277	Pleurodynia, Epidemic	5.6%
278	Olfactory Nerve Injuries	5.6%
279	Torticollis	5.6%
280	Putaminal Hemorrhage	5.6%
281	Auditory Perceptual Disorders	5.5%
282	Ataxia Telangiectasia	5.5%
283	Dysautonomia	5.5%
284	Vagus Nerve Disorder	5.5%
285	Glossopharyngeal Neuralgia	5.5%
286	Abducens Nerve Diseases	5.5%
287	Heavy Metal Poisoning, Nervous System	5.5%
288	Neuromuscular Junction Diseases	5.5%
289	Tauopathies	5.5%
290	Trochlear Nerve Diseases	5.5%
291	Peripheral Nervous System Diseases	5.5%
292	Toxoplasmosis, Congenital	5.4%
293	Malaria, Cerebral	5.3%
294	Brain Diseases, Metabolic, Inborn	5.3%
295	Progressive bulbar palsy	5.3%
296	Bulbar palsy	5.3%
297	Neurocysticercosis	5.3%
298	Horner Syndrome	5.3%
299	Moyamoya Disease	5.2%
300	Tuberous Sclerosis	5.2%
301	Causalgia	5.2%
302	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.1%
303	Infarction, Middle Cerebral Artery	5.1%
304	Infarction, Anterior Cerebral Artery	5.1%
305	Infarction, Posterior Cerebral Artery	5.1%
306	Facial Nerve Injuries	5.1%
307	MELAS Syndrome	5.1%
308	Gastroenteritis, Transmissible, of Swine	5.1%
309	Severe Acute Respiratory Syndrome	5.1%
310	Vertebral Artery Dissection	5.1%
311	Myopathy	5%
312	Optic Neuropathy	5%
313	Facial Nerve Diseases	4.9%
314	Craniocerebral Trauma	4.9%
315	Parasomnia	4.9%
316	Dyssomnias	4.9%
317	Vestibulocochlear Nerve Diseases	4.9%
318	Decerebrate State	4.9%
319	Hemiparesis	4.9%
320	Hydranencephaly	4.9%
321	Meningism	4.9%
322	Neural Tube Defects	4.9%
323	Paresis	4.9%
324	Seizures	4.9%
325	Sensation Disorders	4.9%
326	Tethered Cord Syndrome	4.9%
327	Central Nervous System Neoplasms	4.9%
328	Complex partial seizures	4.9%
329	Iniencephaly	4.9%
330	Craniorachischisis	4.9%
331	Exencephaly	4.9%
332	Monoparesis	4.9%
333	Septo-Optic Dysplasia	4.9%
334	Cortical Dysplasia	4.9%
335	Neurogenic Inflammation	4.9%
336	Gait Disorders, Neurologic	4.9%
337	Neuromuscular Manifestations	4.9%
338	Malformations of Cortical Development	4.9%
339	Sweating, Gustatory	4.9%
340	Auriculotemporal Syndrome	4.9%
341	Wernicke Encephalopathy	4.9%
342	Jet Lag Syndrome	4.8%
343	Central Nervous System Infection	4.8%
344	Multiple Sclerosis	4.8%
345	Myasthenia Gravis, Autoimmune, Experimental	4.7%
346	Cerebral Infarction	4.7%
347	Brain Stem Infarctions	4.7%
348	Measles	4.7%
349	Subarachnoid Hemorrhage, Traumatic	4.7%
350	Carotid Artery, Internal, Dissection	4.7%
351	Spinal Cord Ischemia	4.7%
352	Post-Traumatic Headache	4.6%
353	Tension Headache	4.6%
354	Epilepsy, Complex Partial	4.6%
355	Migraine Disorders	4.6%
356	Abdominal Migraine	4.6%
357	Status Migrainosus	4.6%
358	Cervicogenic Headache	4.6%
359	Refsum Disease	4.6%
360	Frontotemporal dementia	4.6%
361	Brain Concussion	4.6%
362	Diffuse Axonal Injury	4.6%
363	Brain Stem Neoplasms	4.6%
364	Kernicterus	4.5%
365	Pupil Disorders	4.5%
366	Neurobehavioral Manifestations	4.5%
367	Paraneoplastic Encephalomyelitis	4.4%
368	Uveomeningoencephalitic Syndrome	4.4%
369	Sturge-Weber Syndrome	4.4%
370	Vertigo	4.4%
371	Alcohol-Induced Disorders, Nervous System	4.4%
372	Ophthalmoplegia	4.4%
373	External Ophthalmoplegia	4.4%
374	Giant Cell Arteritis	4.3%
375	Temporal Arteritis	4.3%
376	Infectious Mononucleosis	4.3%
377	Reflex Sympathetic Dystrophy	4.2%
378	Nocturnal Myoclonus Syndrome	4.2%
379	Brain Contusion	4.2%
380	Empty Sella Syndrome	4.1%
381	Hyperpituitarism	4.1%
382	Hypopituitarism	4.1%
383	Hypophysitis	4.1%
384	Alice in Wonderland Syndrome	4.1%
385	Waterhouse-Friderichsen Syndrome	4.1%
386	Cerebral Arterial Diseases	4.1%
387	Vertebrobasilar Insufficiency	4.1%
388	Basilar Artery Stenosis	4.1%
389	Vertebral Artery Stenosis	4.1%
390	Intracranial Hemorrhage, Hypertensive	4.1%
391	Transient Cerebral Ischemia	4.1%
392	Tardive Dyskinesia	4.1%
393	Voice Disorders	4.1%
394	Voice Disturbance	4.1%
395	Vocal Cord Paralysis	4%
396	Smith-Magenis syndrome	4%
397	Dural Arteriovenous Fistula	4%
398	Charcot-Marie-Tooth Disease	3.9%
399	Acrodynia	3.8%
400	Lateral Medullary Syndrome	3.8%
401	Carotid Stenosis	3.7%
402	Intracranial Aneurysm	3.7%
403	Intracranial Arteriosclerosis	3.7%
404	Cerebral Atherosclerosis	3.7%
405	Subarachnoid Hemorrhage	3.7%
406	Cerebral Arteriosclerosis	3.7%
407	Cerebral Hemorrhage	3.7%
408	Cerebral Thrombosis	3.7%
409	Intracranial Embolism	3.7%
410	Intracranial Thrombosis	3.7%
411	Alcohol Withdrawal Seizures	3.7%
412	Reflex, Abnormal	3.6%
413	Hyporeflexia	3.6%
414	Hyperreflexia	3.6%
415	Myotonia Congenita	3.4%
416	Cerebrospinal Fluid Otorrhea	3.4%
417	Cerebrospinal Fluid Rhinorrhea	3.4%
418	Neuritis, Autoimmune, Experimental	3.4%
419	Gait Ataxia	3.4%
420	Myotonic Dystrophy	3.3%
421	Carotid Artery Thrombosis	3.3%
422	Cluster Headache	3.3%
423	Migraine with Aura	3.3%
424	Familial Hemiplegic Migraine	3.3%
425	Chronic Paroxysmal Hemicrania	3.3%
426	SUNCT Syndrome	3.3%
427	Paroxysmal Hemicrania	3.3%
428	Choroid Plexus Papilloma	3.2%
429	Akathisia	3.1%
430	Restlessness	3.1%
431	Psychomotor Agitation	3.1%
432	Brachial Plexus Neuritis	3.1%
433	Neuralgic Amyotrophy	3.1%
434	Hematoma, Subdural	3.1%
435	Hematoma, Epidural, Cranial	3.1%
436	Coma, Post-Head Injury	3%
437	Anterior Spinal Artery Syndrome	3%
438	Neuritis	3%
439	Polyneuritis	3%
440	Radiculitis	3%
441	Polyneuropathy	3%
442	Mononeuritis	3%
443	Mononeuropathies	3%
444	Brachial Plexus Neuropathies	3%
445	Radiculopathy	3%
446	Mononeuropathy Multiplex	3%
447	Nerve Root Compression	3%
448	Fabry Disease	3%
449	Acoustic Neuroma	3%
450	Optic Nerve Glioma	3%
451	Hyperprolactinemia	2.9%
452	Alstrom Syndrome	2.9%
453	Subclavian Steal Syndrome	2.9%
454	Pick Disease of the Brain	2.9%
455	Galactosemias	2.8%
456	Urea Cycle Disorders, Inborn	2.8%
457	Tyrosinemias	2.8%
458	Multiple Sclerosis, Chronic Progressive	2.8%
459	Multiple Sclerosis, Relapsing-Remitting	2.8%
460	Gait Apraxia	2.7%
461	Amyloid Neuropathies, Familial	2.7%
462	Myositis	2.7%
463	Optic Atrophy	2.7%
464	Optic Neuritis	2.7%
465	Papilledema	2.7%
466	Strabismus	2.7%
467	Tolosa-Hunt Syndrome	2.7%
468	Isaacs syndrome	2.7%
469	Arsenic Poisoning	2.7%
470	Myotonic Disorders	2.7%
471	Myasthenic Syndromes, Congenital	2.7%
472	Menkes Kinky Hair Syndrome	2.7%
473	Diabetic Neuropathies	2.7%
474	Facial Injuries	2.7%
475	Facial Neuralgia	2.7%
476	Diabetic Amyotrophy	2.7%
477	Diabetic Autonomic Neuropathy	2.7%
478	Sleep Talking	2.7%
479	Manganese Poisoning	2.7%
480	Sleep Disorders, Intrinsic	2.7%
481	Orthostatic intolerance	2.7%
482	Anosmia	2.7%
483	Ataxia	2.7%
484	Athetosis	2.7%
485	Catalepsy	2.7%
486	Dystonia	2.7%
487	Hemiplegia	2.7%
488	Locked-In Syndrome	2.7%
489	Meningeal Neoplasms	2.7%
490	Meningomyelocele	2.7%
491	Muscle Hypertonia	2.7%
492	Muscle hypotonia	2.7%
493	Myoclonus	2.7%
494	Myotonia	2.7%
495	Neuralgia	2.7%
496	Paraplegia	2.7%
497	Pseudobulbar Palsy	2.7%
498	Quadriplegia	2.7%
499	Spasm	2.7%
500	Spastic Paraplegia	2.7%
501	Status Epilepticus	2.7%
502	Taste Disorders	2.7%
503	Tremor	2.7%
504	Spina Bifida	2.7%
505	Monoplegia	2.7%
506	Hypokinesia	2.7%
507	Paraparesis	2.7%
508	Bradykinesia	2.7%
509	Waxy flexibility	2.7%
510	Action Tremor	2.7%
511	Resting Tremor	2.7%
512	Dysosmia	2.7%
513	Quadriparesis	2.7%
514	Mercury Poisoning, Nervous System	2.7%
515	Olfaction Disorders	2.7%
516	Myokymia	2.7%
517	Lead Poisoning, Nervous System	2.7%
518	Vestibular Neuronitis	2.7%
519	Somatosensory Disorders	2.7%
520	Neuropathic pain	2.7%
521	Hyperkinesia	2.7%
522	Intention tremor	2.7%
523	Acromegaly	2.6%
524	Homocystinuria	2.6%
525	Leigh Disease	2.6%
526	Cerebral Amyloid Angiopathy	2.6%
527	Sinus Thrombosis, Intracranial	2.6%
528	Tarsal Tunnel Syndrome	2.5%
529	Cauda Equina Syndrome	2.5%
530	Hand-Arm Vibration Syndrome	2.5%
531	Vision Disorders	2.4%
532	Metamorphopsia	2.4%
533	Visual Impairment	2.4%
534	Fibromyalgia	2.4%
535	Optic Neuropathy, Ischemic	2.4%
536	Anterior Ischemic Optic Neuropathy	2.4%
537	Medial Tibial Stress Syndrome	2.4%
538	Facial Hemiatrophy	2.4%
539	Melkersson-Rosenthal Syndrome	2.4%
540	Mitochondrial Myopathies	2.4%
541	Anisocoria	2.4%
542	Confusion	2.4%
543	Facial paralysis	2.4%
544	Lethargy	2.4%
545	Memory Disorders	2.4%
546	Muscle Cramp	2.4%
547	Perceptual Disorders	2.4%
548	Psychomotor Disorders	2.4%
549	Tonic Pupil	2.4%
550	Eosinophilia-Myalgia Syndrome	2.4%
551	Anhedonia	2.4%
552	Disorientation	2.4%
553	Facial Paresis	2.4%
554	Memory Loss	2.4%
555	Hemisensory Neglect	2.4%
556	Dysacusis	2.4%
557	Sleep Bruxism	2.4%
558	Anencephaly	2.4%
559	Meningocele	2.4%
560	Muscular Atrophy	2.4%
561	Respiratory Paralysis	2.4%
562	Encephalocele	2.4%
563	Tetany	2.4%
564	Carpal Tunnel Syndrome	2.3%
565	neurofibroma	2.3%
566	Sciatica	2.3%
567	Hematoma, Subdural, Intracranial	2.3%
568	Hematoma, Subdural, Chronic	2.3%
569	Hematoma, Subdural, Acute	2.3%
570	Duane Retraction Syndrome	2.2%
571	Consciousness Disorders	2.2%
572	Mental Retardation	2.2%
573	Muscle Weakness	2.2%
574	Depressed Level of Consciousness	2.2%
575	Mental deficiency	2.2%
576	Intellectual Disability	2.2%
577	Mobius Syndrome	2.2%
578	Catatonia	2.2%
579	Prolactinoma	2.2%
580	Growth Hormone-Secreting Pituitary Adenoma	2.2%
581	Familial Periodic Paralysis	2.2%
582	Aphonia	2.2%
583	Sleep Deprivation	2.2%
584	Dysphonia	2.2%
585	Zellweger Syndrome	2.2%
586	Cavernous Sinus Thrombosis	2.1%
587	Sagittal Sinus Thrombosis	2.1%
588	Myalgia	2%
589	Neuronal Ceroid-Lipofuscinoses	2%
590	Classical Lissencephalies and Subcortical Band Heterotopias	1.9%
591	Nelson Syndrome	1.9%
592	Aicardi's syndrome	1.9%
593	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.9%
594	Hoarseness	1.9%
595	Cockayne Syndrome	1.8%
596	Alcohol Withdrawal Delirium	1.8%
597	Cubital Tunnel Syndrome	1.8%
598	Sciatic Neuropathy	1.7%
599	Ulnar Neuropathies	1.7%
600	Lesion of Sciatic Nerve	1.7%
601	Ulnar Neuritis	1.7%
602	Radial nerve compression	1.7%
603	Radial Tunnel Syndrome	1.7%
604	Peroneal Neuropathies	1.7%
605	Radial Neuropathy	1.7%
606	Median Neuropathy	1.7%
607	Sciatic Nerve Palsy	1.7%
608	Femoral Neuropathy	1.7%
609	Tibial Neuropathy	1.7%
610	Ulnar Nerve Palsy	1.7%
611	Postural Orthostatic Tachycardia Syndrome	1.7%
612	Radial nerve palsy	1.7%
613	Glycogen storage disease type II	1.7%
614	Holoprosencephaly	1.7%
615	Optic Atrophy, Hereditary, Leber	1.6%
616	Kearns-Sayre syndrome	1.6%
617	Thoracic Outlet Syndrome	1.6%
618	Esotropia	1.6%
619	Exotropia	1.6%
620	Hypotension, Orthostatic	1.6%
621	Sleep Apnea Syndromes	1.6%
622	Polymyositis	1.6%
623	Post-Exercise Hypotension	1.6%
624	Disorders of Excessive Somnolence	1.5%
625	Sleep Initiation and Maintenance Disorders	1.5%
626	Night Terrors	1.5%
627	Somnambulism	1.5%
628	Trigeminal Nerve Disorder	1.5%
629	Transient Insomnia	1.5%
630	Sleep Paralysis	1.5%
631	Chronic Insomnia	1.5%
632	REM Sleep Behavior Disorder	1.5%
633	Hypersomnia	1.5%
634	Dermal Sinus	1.5%
635	Dysgeusia	1.5%
636	Formication	1.5%
637	Hyperalgesia	1.5%
638	Hyperesthesia	1.5%
639	Hypesthesia	1.5%
640	Language Disorders	1.5%
641	Numbness	1.5%
642	Paresthesia	1.5%
643	Paraparesis, Spastic	1.5%
644	Spina Bifida Cystica	1.5%
645	Trismus	1.5%
646	Spina Bifida Occulta	1.5%
647	Epilepsia Partialis Continua	1.5%
648	Hypogeusia	1.5%
649	Meningeal Carcinomatosis	1.5%
650	Brown-Sequard Syndrome	1.5%
651	Lissencephaly	1.5%
652	Polymicrogyria	1.5%
653	Pachygyria	1.5%
654	Schizencephaly	1.5%
655	Lockjaw	1.5%
656	Allodynia	1.5%
657	Lead Poisoning, Nervous System, Childhood	1.5%
658	Lead Poisoning, Nervous System, Adult	1.5%
659	Periventricular Nodular Heterotopia	1.5%
660	Ageusia	1.5%
661	Alexia	1.5%
662	Dyslexia	1.5%
663	Eye Injuries	1.4%
664	Muscular Dystrophy	1.4%
665	Congenital nystagmus	1.4%
666	Orbital Myositis	1.4%
667	Diplopia	1.4%
668	Muscle Rigidity	1.4%
669	Muscle Spasticity	1.4%
670	Scotoma	1.4%
671	Photophobia	1.4%
672	Cogwheel Rigidity	1.4%
673	Hemifacial Spasm	1.4%
674	Amaurosis	1.4%
675	Blindness	1.4%
676	Nuchal Rigidity	1.4%
677	Pyomyositis	1.4%
678	Agnosia	1.4%
679	Apraxias	1.4%
680	Hallucinations	1.4%
681	Hemianopsia	1.4%
682	Hyperacusis	1.4%
683	Tinnitus	1.4%
684	Visual Agnosia	1.4%
685	Anosognosia	1.4%
686	Wernicke-Korsakoff Syndrome	1.4%
687	Phonophobia	1.4%
688	Hearing Loss	1.4%
689	Sarcopenia	1.4%
690	Neurofibrosarcoma	1.3%
691	Gaucher Disease	1.3%
692	Amnesia	1.3%
693	Delirium	1.3%
694	Dissociative Amnesia	1.3%
695	Color blindness	1.3%
696	Global Amnesia	1.3%
697	Cri-du-Chat Syndrome	1.3%
698	Down Syndrome	1.3%
699	Trisomy 21	1.3%
700	POEMS Syndrome	1.3%
701	Meningioma	1.3%
702	Williams Syndrome	1.3%
703	Microcephaly	1.3%
704	Macrocephaly	1.3%
705	Hypokalemic periodic paralysis	1.3%
706	Porencephaly	1.3%
707	Prader-Willi Syndrome	1.2%
708	Phantom pain	1.2%
709	Phantom Limb Pain	1.2%
710	Polyradiculopathy	1.1%
711	Niemann-Pick Disease, Type C	1%
712	Tay-Sachs Disease	1%
713	Sleep Apnea, Obstructive	1%
714	Sleep Apnea, Central	1%
715	Rubinstein-Taybi Syndrome	1%
716	Narcolepsy	1%
717	Trigeminal Neuralgia	1%
718	Kleine-Levin Syndrome	1%
719	Agraphia	1%
720	Anomia	1%
721	Cluttering	1%
722	Language Development Disorders	1%
723	Speech Disorders	1%
724	Syncope	1%
725	Stupor	1%
726	Dysgraphia	1%
727	Presyncope	1%
728	Dyslalia	1%
729	Eye Burns	0.9%
730	Welander Distal Myopathy	0.9%
731	Amaurosis Fugax	0.9%
732	Blindness, Cortical	0.9%
733	Dyscalculia	0.9%
734	Rett Syndrome	0.9%
735	Deafness	0.9%
736	Hearing Loss, Sudden	0.9%
737	Gerstmann Syndrome	0.9%
738	Hearing Loss, Bilateral	0.9%
739	Hearing Loss, High-Frequency	0.9%
740	Hearing Loss, Mixed Conductive-Sensorineural	0.9%
741	Prosopagnosia	0.9%
742	Apraxia, Ideomotor	0.9%
743	Charles Bonnet Syndrome	0.9%
744	Hearing Loss, Unilateral	0.9%
745	Complete Hearing Loss	0.9%
746	Alien Hand Syndrome	0.9%
747	Deaf Mutism	0.9%
748	Dermatomyositis	0.8%
749	Corneal Scar	0.8%
750	Muscular Dystrophy, Duchenne	0.8%
751	Retrograde amnesia	0.8%
752	Amnesia, Anterograde	0.8%
753	Fragile X Syndrome	0.7%
754	Cataplexy	0.7%
755	Aphasia	0.7%
756	Articulation Disorders	0.7%
757	Echolalia	0.7%
758	Stuttering	0.7%
759	Dysphasia	0.7%
760	Mutism	0.7%
761	Selective Mutism	0.7%
762	Corneal Perforation	0.6%
763	Mucopolysaccharidosis II	0.6%
764	Dysarthria	0.6%
765	Alexia, Pure	0.5%

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