MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pelger-Huet Anomaly

(UMLS:C0030779)

Definition:: Autosomal dominant anomaly characterized by abnormal ovoid shape GRANULOCYTE nuclei and their clumping chromatin. Mutations in the LAMIN B receptor gene that results in reduced protein levels are associated with the disorder. Heterozygote individuals are healthy with normal granulocyte function while homozygote individuals occasionally have skeletal anomalies, developmental delay, and seizures.
UMLS ID:: C0030779
MeSH ID:: D010381

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.553.696

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.784

Synonym(s)

Pelger-Huet Anomaly

PELGER-HUET ANOMALY

Pelger Huet anomaly

Pelger-Huet anomaly

Pelger-Huet; anomaly

Pelger-Hu毛t anomaly

anomaly huet pelger

anomaly; Pelger-Huet

pelger huet anomaly

10.

pelger-huet anomaly

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ethylnitrosourea		27725143	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Eosinophilia	31.8%
2	Leukopenia	31.8%
3	Leukostasis	31.8%
4	Wiskott-Aldrich Syndrome	31%
5	Anemia, Sickle Cell	30.9%
6	Thalassemia	30.9%
7	Thrombasthenia	28.5%
8	Antithrombin III Deficiency	28.5%
9	Protein C Deficiency	28.5%
10	Afibrinogenemia	26.7%
11	Factor VII Deficiency	26.7%
12	Factor X Deficiency	26.7%
13	Factor XII Deficiency	26.7%
14	Hemophilia A	26.7%
15	Activated Protein C Resistance	26.7%
16	Factor II deficiency	26.7%
17	Factor VIII Deficiency	26.7%
18	Factor V deficiency	26.7%
19	Factor XI Deficiency	26.7%
20	Hypoprothrombinemias	26.7%
21	Chronic granulomatous disease	26.2%
22	Sickle Cell Trait	25%
23	Leukemoid Reaction	25%
24	Disseminated Intravascular Coagulation	24.3%
25	Protein S Deficiency	24.3%
26	Leukocytosis	24.1%
27	Pleocytosis	24.1%
28	Agranulocytosis	23.6%
29	Lymphocytosis	23.6%
30	Hypereosinophilic syndrome	23.6%
31	Fragile X Syndrome	23.4%
32	Anemia, Diamond-Blackfan	23.1%
33	Thrombocythemia, Essential	22.4%
34	Neoplastic Syndromes, Hereditary	21.8%
35	Anemia	20.9%
36	Blood Coagulation Disorders	20.9%
37	Blood Platelet Disorders	20.9%
38	Bone Marrow Diseases	20.9%
39	Hemorrhagic Disorders	20.9%
40	Methemoglobinemia	20.9%
41	Pancytopenia	20.9%
42	Polycythemia	20.9%
43	Sulfhemoglobinemia	20.9%
44	Thrombophilia	20.9%
45	Erythrocytosis	20.9%
46	Aicardi's syndrome	20.9%
47	Multiple Epiphyseal Dysplasia	20.7%
48	Osteochondrodysplasias	20.7%
49	Werner Syndrome	20.7%
50	Myasthenic Syndromes, Congenital	20.7%
51	CHARGE Syndrome	20.5%
52	Familial Mediterranean Fever	20.5%
53	Beckwith-Wiedemann Syndrome	20.3%
54	Wolf-Hirschhorn Syndrome	20.3%
55	Muscular Dystrophy, Duchenne	19.9%
56	Rett Syndrome	19.8%
57	Neutropenia	19.6%
58	Acute Chest Syndrome	19.2%
59	Albinism	19%
60	Cystic Fibrosis	18.8%
61	Ichthyosis, X-Linked	18.6%
62	Mucopolysaccharidosis II	18.5%
63	Fanconi Anemia	18.2%
64	Lymphopenia	17.9%
65	Infectious Mononucleosis	17.9%
66	Thrombocytosis	17.6%
67	Job Syndrome	17.6%
68	Cockayne Syndrome	17.6%
69	Febrile Neutropenia	17.5%
70	Alstrom Syndrome	17.3%
71	Anemia, Neonatal	17.2%
72	Nail-Patella Syndrome	17.2%
73	Dwarfism	17.1%
74	Smith-Magenis syndrome	17%
75	Cri-du-Chat Syndrome	16.8%
76	Down Syndrome	16.8%
77	Trisomy 21	16.8%
78	Transfusion Reaction	16.4%
79	Hypotensive Transfusion Reaction	16.4%
80	Muscular Dystrophy	16.3%
81	Osteogenesis Imperfecta	16.3%
82	Menkes Kinky Hair Syndrome	16.3%
83	Bone Marrow Neoplasms	16.2%
84	Autoimmune Lymphoproliferative Syndrome	16.1%
85	Vitamin K Deficiency	16.1%
86	Pregnancy Complications, Hematologic	15.8%
87	Hematologic Neoplasms	15.8%
88	Amino Acid Metabolism, Inborn Errors	15.3%
89	Carbohydrate Metabolism, Inborn Errors	15.3%
90	Metal Metabolism, Inborn Errors	15.3%
91	Progeria	15.3%
92	Lysosomal Storage Diseases	15.3%
93	Cytochrome-c Oxidase Deficiency	15.3%
94	Peroxisomal Disorders	15.3%
95	Hemoglobinuria, Paroxysmal	15%
96	Pulmonary Eosinophilia	14.9%
97	Eosinophilic Pneumonia	14.9%
98	Neuronal Ceroid-Lipofuscinoses	14.9%
99	Polycythemia Vera	14.8%
100	Holoprosencephaly	14.8%
101	Smith-Lemli-Opitz Syndrome	14.8%
102	Deformity	14.6%
103	Hydrops Fetalis	14.4%
104	Ectodermal Dysplasia	14.4%
105	Aplasia Cutis Congenita	14.4%
106	Prader-Willi Syndrome	14.3%
107	Eosinophilia-Myalgia Syndrome	14.3%
108	Kartagener Syndrome	14.1%
109	Primary Ciliary Dyskinesia	13.8%
110	Anemia, Hemolytic	13.6%
111	Anemia, Macrocytic	13.6%
112	Hypoproteinemia	13.6%
113	Thrombocytopenia	13.6%
114	MYELODYSPLASTIC SYNDROME	13.6%
115	Angioedemas, Hereditary	13.4%
116	Polycystic Kidney Diseases	13.3%
117	Williams Syndrome	13.3%
118	Myotonic Dystrophy	13.3%
119	Adrenoleukodystrophy	13.2%
120	Marfan Syndrome	13.2%
121	Glycogen storage disease type II	13.1%
122	Rubinstein-Taybi Syndrome	12.9%
123	Fabry Disease	12.9%
124	Sjogren-Larsson Syndrome	12.7%
125	Mucopolysaccharidosis III	12.6%
126	Tuberous Sclerosis	12.6%
127	Refsum Disease	12.5%
128	Alkaptonuria	12.5%
129	Glycogen Storage Disease	12.5%
130	Hypophosphatasia	12.5%
131	Propionic acidemia	12.5%
132	Dihydropyrimidine Dehydrogenase Deficiency	12.5%
133	Cystinosis	12.5%
134	Pseudoxanthoma Elasticum	12.4%
135	Cutis Laxa	12.3%
136	Lymphatic Abnormalities	12.3%
137	Galactosemias	12.3%
138	Urea Cycle Disorders, Inborn	12.3%
139	Tyrosinemias	12.3%
140	Purpura, Thrombotic Thrombocytopenic	12.3%
141	Retinitis Pigmentosa	12.2%
142	Pigmentary retinopathy	12.2%
143	Hepatolenticular Degeneration	12.2%
144	Lymphatic Diseases	12.2%
145	Porokeratosis	12.2%
146	Keratoderma, Palmoplantar	12.2%
147	Amyloid Neuropathies, Familial	12%
148	Welander Distal Myopathy	12%
149	Retinal Dysplasia	11.9%
150	Kallmann Syndrome	11.8%
151	Aniridia	11.8%
152	Epidermolysis Bullosa	11.5%
153	Eosinophilic Granuloma	11.5%
154	Glycogen Storage Disease Type I	11.2%
155	Glycogen Storage Disease Type V	11.2%
156	Gaucher Disease	11.1%
157	Classical Lissencephalies and Subcortical Band Heterotopias	11.1%
158	Optic Atrophy, Hereditary, Leber	11%
159	Agammaglobulinemia	11%
160	Polycystic Kidney, Autosomal Dominant	10.9%
161	Fetal Diseases	10.9%
162	Hyperphosphaturia	10.9%
163	Tay-Sachs Disease	10.6%
164	Niemann-Pick Disease, Type C	10.5%
165	Homocystinuria	10.4%
166	Duane Retraction Syndrome	10.3%
167	Leigh Disease	10.3%
168	Paraproteinemias	10.3%
169	Canavan Disease	10.3%
170	Alexander Disease	10.3%
171	Porphyrias, Hepatic	10.2%
172	Primary Myelofibrosis	10.1%
173	Anemia, Megaloblastic	10.1%
174	Myelofibrosis	10.1%
175	Myeloid Metaplasia	10.1%
176	Hypoalbuminemia	10.1%
177	bone marrow fibrosis	10.1%
178	Thrombotic Microangiopathies	10.1%
179	Peutz-Jeghers Syndrome	10.1%
180	Myotonia Congenita	10.1%
181	Brain Diseases, Metabolic, Inborn	10.1%
182	Cryoglobulinemia	10%
183	Dystonia Musculorum Deformans	10%
184	Monoclonal Gammopathy of Undetermined Significance	10%
185	Hyperkeratosis, Epidermolytic	10%
186	Hypolipoproteinemias	9.9%
187	Papillon-Lefevre Disease	9.9%
188	Zellweger Syndrome	9.9%
189	Lafora Disease	9.9%
190	Unverricht-Lundborg Syndrome	9.9%
191	Hyperlipidemia, Familial Combined	9.9%
192	Hyperlipoproteinemia Type III	9.9%
193	Carbamoyl-Phosphate Synthase I Deficiency Disease	9.7%
194	Autoimmune thrombocytopenia	9.7%
195	Immune thrombocytopenic purpura	9.7%
196	Lymphangiectasis, Intestinal	9.5%
197	Charcot-Marie-Tooth Disease	9.4%
198	Antley-Bixler Syndrome Phenotype	9.4%
199	Abdominal Cramps	9.3%
200	Abnormalities, Drug-Induced	9.3%
201	Amniotic Band Syndrome	9.3%
202	Asphyxia Neonatorum	9.3%
203	Infant, Premature, Diseases	9.3%
204	Situs Inversus	9.3%
205	Infantile Colic	9.3%
206	Waldenstrom Macroglobulinemia	9.2%
207	Ataxia Telangiectasia	9%
208	Hemolytic-Uremic Syndrome	9%
209	Multiple Endocrine Neoplasia	8.9%
210	Hypoalphalipoproteinemias	8.9%
211	Heavy Chain Disease	8.7%
212	Congenital Hypothyroidism	8.7%
213	Dermatitis, Atopic	8.7%
214	Purpura, Hyperglobulinemic	8.5%
215	Familial Periodic Paralysis	8.4%
216	Hypergammaglobulinemia	8.3%
217	POEMS Syndrome	8.3%
218	Lactose Intolerance	8.3%
219	Variegate Porphyria	8.3%
220	Acute intermittent porphyria	8.3%
221	Porphyria Cutanea Tarda	8.3%
222	Hyperhomocysteinemia	8.3%
223	Renal Aminoacidurias	8.2%
224	Fanconi Syndrome	8.2%
225	Pseudohypoaldosteronism	8.2%
226	Liddle Syndrome	8.2%
227	Hyperlipoproteinemia Type IV	8.2%
228	Hyperlipoproteinemia Type V	8.2%
229	Transfusion-Related Acute Lung Injury	8.2%
230	Klinefelter Syndrome	8.2%
231	Ecchymosis	8.1%
232	Petechiae	8.1%
233	Purpura	8.1%
234	Xeroderma Pigmentosum	8.1%
235	Thrombocytopenic purpura	8%
236	Xeroderma	8%
237	Mobius Syndrome	8%
238	Meconium Aspiration Syndrome	7.9%
239	Atypical Hemolytic Uremic Syndrome	7.7%
240	Kernicterus	7.6%
241	Behcet Syndrome	7.5%
242	Leukemia, Myelomonocytic, Chronic	7.5%
243	Multiple Myeloma	7.5%
244	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	7.5%
245	Hypokalemic periodic paralysis	7.4%
246	Anencephaly	7.4%
247	Cystinuria	7.3%
248	Eye Abnormalities	7.3%
249	Cardiovascular Abnormalities	7.3%
250	Basal Cell Nevus Syndrome	7.2%
251	Gout	7.2%
252	Multiple Endocrine Neoplasia Type 1	7.1%
253	Pseudohypoparathyroidism	7.1%
254	Friedreich Ataxia	7.1%
255	Renal tubular acidosis	7%
256	Skin Abnormalities	7%
257	Congenital Microtia	7%
258	Adenitis	7%
259	Histiocytosis	7%
260	Lymphadenitis	7%
261	Lymphangitis	7%
262	Lymphedema	7%
263	Splenic Diseases	7%
264	Thymus Hyperplasia	7%
265	Pseudolymphoma	7%
266	Lymphadenopathy	7%
267	Turner Syndrome	6.9%
268	Persistent Fetal Circulation Syndrome	6.9%
269	Congenital diaphragmatic hernia	6.8%
270	Prune Belly Syndrome	6.8%
271	Twins, Conjoined	6.8%
272	Waardenburg Syndrome	6.8%
273	Umbilical hernia	6.8%
274	Huntington Disease	6.6%
275	Arthritis, Gouty	6.3%
276	Waterhouse-Friderichsen Syndrome	6.2%
277	Maxillofacial Abnormalities	6.2%
278	Dural Arteriovenous Fistula	6.2%
279	Leukemia, Myeloid, Chronic-Phase	6.2%
280	Familial Hypophosphatemic Rickets	6.2%
281	Anemia, Pernicious	6.2%
282	Dextrocardia	6.1%
283	Shwartzman Phenomenon	6%
284	Hemangioma, Cavernous	6%
285	Scurvy	6%
286	Purpura Fulminans	6%
287	Nephroblastoma	6%
288	Urogenital Abnormalities	5.8%
289	Neonatal Abstinence Syndrome	5.6%
290	Fetal Growth Retardation	5.5%
291	Fetal Hypoxia	5.4%
292	Congenital nystagmus	5.4%
293	Fetal Alcohol Spectrum Disorders	5.4%
294	Glycosuria, Renal	5.4%
295	Toxoplasmosis, Congenital	5.4%
296	Syphilis, Congenital	5.4%
297	Adenomatous Polyposis Coli	5.4%
298	Lymphocele	5.3%
299	Lymphoproliferative Disorders	5.3%
300	Microcephaly	5.2%
301	Macrocephaly	5.2%
302	Anophthalmos	5.2%
303	Anus, Imperforate	5.2%
304	Hydranencephaly	5.2%
305	Microphthalmos	5.2%
306	Neural Tube Defects	5.2%
307	Paralysis, Obstetric	5.2%
308	Retinopathy of Prematurity	5.2%
309	Tethered Cord Syndrome	5.2%
310	Iniencephaly	5.2%
311	Craniorachischisis	5.2%
312	Limb Deformities, Congenital	5.2%
313	Exencephaly	5.2%
314	Septo-Optic Dysplasia	5.2%
315	Craniofacial Abnormalities	5.2%
316	Cortical Dysplasia	5.2%
317	Malformations of Cortical Development	5.2%
318	Anorectal Malformations	5.2%
319	Thymus Neoplasms	5.2%
320	Bloom Syndrome	5.1%
321	Bronchopulmonary Dysplasia	5%
322	Porencephaly	4.9%
323	Acrocephalosyndactylia	4.8%
324	Craniosynostosis	4.7%
325	Syndactyly	4.7%
326	Brachycephaly	4.7%
327	Scimitar Syndrome	4.7%
328	Elephantiasis	4.5%
329	Hypersplenism	4.5%
330	Sarcoidosis	4.5%
331	Elephantiasis Nostras Verrucosa	4.5%
332	Congenital Hyperinsulinism	4.5%
333	Chorioamnionitis	4.5%
334	Denys-Drash Syndrome	4.5%
335	MELAS Syndrome	4.4%
336	Amelia	4.2%
337	Arachnodactyly	4.2%
338	Ectopia Cordis	4.2%
339	Ectromelia	4.2%
340	Hemimelia	4.2%
341	Meningomyelocele	4.2%
342	Noonan Syndrome	4.2%
343	Phocomelia	4.2%
344	Sirenomelia	4.2%
345	Spina Bifida	4.2%
346	Polydactyly	4.2%
347	Brachydactyly	4.2%
348	Plagiocephaly	4.2%
349	Lower Extremity Deformities, Congenital	4.2%
350	Upper Extremity Deformities, Congenital	4.2%
351	Single umbilical artery	4.2%
352	Poland Syndrome	4.2%
353	Blepharophimosis	4.2%
354	Laryngostenosis	4.2%
355	Mouth Abnormalities	4.2%
356	Respiratory Distress Syndrome, Newborn	4.2%
357	Esophageal Atresia	4.1%
358	Intestinal Atresia	4.1%
359	Mucocutaneous Lymph Node Syndrome	4.1%
360	Horseshoe Kidney	4.1%
361	Pectus excavatum	4.1%
362	Cleft Palate	4.1%
363	Klippel-Feil Syndrome	4.1%
364	Gastroschisis	4.1%
365	Synostosis	4.1%
366	Acrodermatitis	4.1%
367	Gianotti-Crosti Syndrome	4.1%
368	Jaw Abnormalities	4%
369	Abnormalities, Radiation-Induced	3.8%
370	Dermal Sinus	3.7%
371	Spina Bifida Cystica	3.7%
372	Spina Bifida Occulta	3.7%
373	Lissencephaly	3.7%
374	Polymicrogyria	3.7%
375	Pachygyria	3.7%
376	Schizencephaly	3.7%
377	Periventricular Nodular Heterotopia	3.7%
378	Micrognathism	3.6%
379	Pierre Robin Syndrome	3.6%
380	Arthrogryposis	3.5%
381	Choanal Atresia	3.5%
382	Tracheobronchomegaly	3.5%
383	Laryngocele	3.5%
384	Choledochal Cyst	3.4%
385	Granuloma	3.4%
386	Hermaphroditism	3.4%
387	Histiocytic Disorders, Malignant	3.4%
388	Disorders of Sex Development	3.4%
389	Splenic Infarction	3.4%
390	Splenic Neoplasms	3.4%
391	Cryptorchidism	3.4%
392	Hypospadias	3.4%
393	Histiocytosis, Langerhans-Cell	3.4%
394	Tumor Lysis Syndrome	3.4%
395	Central Nervous System Cysts	3.4%
396	Dandy-Walker Syndrome	3.4%
397	Lymphohistiocytosis, Hemophagocytic	3.4%
398	Erdheim-Chester Disease	3.4%
399	Aortic coarctation	3.4%
400	Cor Triatriatum	3.4%
401	Coronary Vessel Anomalies	3.4%
402	Dental Enamel Hypoplasia	3.4%
403	Patent ductus arteriosus	3.4%
404	Ebstein Anomaly	3.4%
405	Heart Septal Defects	3.4%
406	Hyaline Membrane Disease	3.4%
407	Hypodontia	3.4%
408	Macrostomia	3.4%
409	Meningocele	3.4%
410	Microstomia	3.4%
411	Tetralogy of Fallot	3.4%
412	Transposition of Great Vessels	3.4%
413	Hypoplastic Left Heart Syndrome	3.4%
414	May-Thurner Syndrome	3.4%
415	Encephalocele	3.4%
416	Craniofacial Dysostosis	3.3%
417	Leukomalacia, Periventricular	3.3%
418	Nesidioblastosis	3.3%
419	Wolff-Parkinson-White Syndrome	3.3%
420	Ophthalmia Neonatorum	3.3%
421	Retrognathia	3.2%
422	Aortopulmonary Septal Defect	3%
423	Double Outlet Right Ventricle	3%
424	Endocardial Cushion Defects	3%
425	Laryngomalacia	3%
426	Myocardial bridging	3%
427	Aorticopulmonary Septal Defect	3%
428	Pectus carinatum	2.9%
429	Hyperandrogenism	2.9%
430	Bladder Exstrophy	2.9%
431	Epispadias	2.9%
432	Prognathism	2.9%
433	Multicystic Dysplastic Kidney	2.9%
434	Sezary Syndrome	2.9%
435	Long QT Syndrome	2.8%
436	Platybasia	2.8%
437	Tricuspid Atresia	2.8%
438	Arrhythmogenic Right Ventricular Dysplasia	2.8%
439	Truncus Arteriosus, Persistent	2.8%
440	Gonadal Dysgenesis	2.8%
441	Splenic Rupture	2.8%
442	Bronchomalacia	2.8%
443	Goldenhar Syndrome	2.8%
444	Adrenogenital Syndrome	2.8%
445	Tracheomalacia	2.8%
446	Ovotesticular Disorders of Sex Development	2.8%
447	Lymphoma	2.7%
448	Thymoma	2.7%
449	Malignant histiocytosis	2.5%
450	Sarcoidosis, Pulmonary	2.5%
451	Histiocytic sarcoma	2.5%
452	Mandibulofacial Dysostosis	2.5%
453	Romano-Ward Syndrome	2.5%
454	Talipes	2.3%
455	Congenital clubfoot	2.2%
456	Vertical Talus	2.2%
457	Splenosis	2%
458	Hodgkin Disease	2%
459	Lymphoma, Non-Hodgkin	2%
460	Leukemia, T-Cell	2%
461	Leukemia, B-Cell	2%
462	Arteriovenous fistula	1.9%
463	Composite Lymphoma	1.7%
464	Lymphangioleiomyomatosis	1.6%
465	Lymphoma, Follicular	1.6%
466	T-Cell Lymphoma	1.6%
467	Mantle cell lymphoma	1.6%
468	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
469	Leukemia, Large Granular Lymphocytic	1.6%
470	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
471	Lymphoma, T-Cell, Cutaneous	1.5%
472	Lymphoma, AIDS-Related	1.5%
473	Enteropathy-Associated T-Cell Lymphoma	1.5%
474	Primary Effusion Lymphoma	1.5%
475	Mycosis Fungoides	1.4%
476	Lymphomatoid Papulosis	1.4%
477	Plasmablastic lymphoma	1.4%
478	Lymphomatoid Granulomatosis	1.2%
479	Burkitt Lymphoma	1.1%

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