MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Porphyrias, Hepatic

(UMLS:C0162533)

Definition:: A group of metabolic diseases due to deficiency of one of a number of LIVER enzymes in the biosynthetic pathway of HEME. They are characterized by the accumulation and increased excretion of PORPHYRINS or its precursors. Clinical features include neurological symptoms (PORPHYRIA, ACUTE INTERMITTENT), cutaneous lesions due to photosensitivity (PORPHYRIA CUTANEA TARDA), or both (HEREDITARY COPROPORPHYRIA). Hepatic porphyrias can be hereditary or acquired as a result of toxicity to the hepatic tissues.
UMLS ID:: C0162533
MeSH ID:: D017094

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.552.830

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.850.742

Classification 3:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.827.742

Classification 4:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.811.400

Synonym(s)

Porphyrias, Hepatic

Hepatic porphyria

Hepatic porphyria, NOS

Porphyria, hepatic

Associated Drug(s)

	Name	Reference(s)	Data Source
1	3,5-diethoxycarbonyl-1,4-dihydrocollidine	10751352 21889565 22384083	CTD
2	Allylisopropylacetamide	21889565	CTD
3	Griseofulvin	1751019 6679936 19043281	CTD
4	Hexachlorobenzene	11475000	CTD
5	Polychlorinated Dibenzodioxins	9443932 15371557	CTD
6	Primidone	15101839	CTD
7	Ursodeoxycholic Acid	1751019	CTD
8	Valproic Acid	15101839	CTD
9	fomesafen	12758057	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Porokeratosis	32.7%
2	Keratoderma, Palmoplantar	32.7%
3	Epidermolysis Bullosa	31.3%
4	Xeroderma Pigmentosum	30.3%
5	Cutis Laxa	30.1%
6	Dermatitis, Atopic	29.9%
7	Albinism	28.9%
8	Ectodermal Dysplasia	28.4%
9	Aplasia Cutis Congenita	28.4%
10	Ichthyosis, X-Linked	28.2%
11	Sjogren-Larsson Syndrome	26.6%
12	Papillon-Lefevre Disease	24.2%
13	Pseudoxanthoma Elasticum	23.9%
14	Hyperkeratosis, Epidermolytic	20.5%
15	Biliary cirrhosis	19.3%
16	Hepatolenticular Degeneration	17.9%
17	Menkes Kinky Hair Syndrome	17.5%
18	Lipodystrophy	17.3%
19	Pyoderma Gangrenosum	17.3%
20	Zellweger Syndrome	17.2%
21	Fatty Liver, Alcoholic	17.2%
22	Hepatitis, Alcoholic	17.2%
23	Liver Cirrhosis, Alcoholic	17.2%
24	Lipomatosis	17%
25	Werner Syndrome	17%
26	Fatty Liver	16.4%
27	Hepatitis	16.4%
28	Portal Hypertension	16.4%
29	Liver Cirrhosis	16.4%
30	Focal Nodular Hyperplasia	16.4%
31	Hepatic Insufficiency	16.4%
32	Steatohepatitis	16.4%
33	Necrobiosis Lipoidica Diabeticorum	16.3%
34	Smith-Lemli-Opitz Syndrome	16.2%
35	Leigh Disease	16.1%
36	Liver neoplasms	15.7%
37	Pseudohypoparathyroidism	15.6%
38	Behcet Syndrome	15.1%
39	Brain Diseases, Metabolic, Inborn	15.1%
40	Galactosemias	14.8%
41	Urea Cycle Disorders, Inborn	14.8%
42	Tyrosinemias	14.8%
43	Carbamoyl-Phosphate Synthase I Deficiency Disease	14.7%
44	Nail-Patella Syndrome	14.5%
45	Lactose Intolerance	14.5%
46	Xeroderma	14.4%
47	Homocystinuria	14.4%
48	Reye Syndrome	14.4%
49	Glycogen storage disease type II	14.2%
50	Liver Diseases, Parasitic	14.1%
51	Cystic Fibrosis	13.9%
52	Adrenoleukodystrophy	13.9%
53	Mucopolysaccharidosis II	13.8%
54	Hepatic Veno-Occlusive Disease	13.8%
55	Lupus Erythematosus, Cutaneous	13.8%
56	Panniculitis	13.8%
57	Peliosis Hepatis	13.8%
58	Systemic Scleroderma	13.8%
59	Skin Abnormalities	13.8%
60	Wasting Syndrome	13.8%
61	Hepatopulmonary Syndrome	13.8%
62	Morphea	13.8%
63	Hepatomegaly	13.6%
64	Gaucher Disease	13.6%
65	Congenital Hyperinsulinism	13.6%
66	Hepatic Vein Thrombosis	13.5%
67	Liver Abscess	13.5%
68	Budd-Chiari Syndrome	13.5%
69	Acne Vulgaris	13.5%
70	Amino Acid Metabolism, Inborn Errors	13.5%
71	Carbohydrate Metabolism, Inborn Errors	13.5%
72	Contact Dermatitis	13.5%
73	Eczema	13.5%
74	Erythema Multiforme	13.5%
75	Esophageal and Gastric Varices	13.5%
76	Hypercalcemia	13.5%
77	Hypocalcemia	13.5%
78	Intertrigo	13.5%
79	Metal Metabolism, Inborn Errors	13.5%
80	Milk-Alkali Syndrome	13.5%
81	Neurodermatitis	13.5%
82	Progeria	13.5%
83	Rhinophyma	13.5%
84	Lysosomal Storage Diseases	13.5%
85	Perioral Dermatitis	13.5%
86	Cytochrome-c Oxidase Deficiency	13.5%
87	Peroxisomal Disorders	13.5%
88	Acne	13.5%
89	Amyloid Neuropathies, Familial	13.5%
90	Acrodermatitis	13.5%
91	Gianotti-Crosti Syndrome	13.5%
92	Fabry Disease	13.5%
93	Liver Abscess, Amebic	13.4%
94	Hyperphosphaturia	13.4%
95	Cockayne Syndrome	13.4%
96	Hyperhomocysteinemia	13.3%
97	Neuronal Ceroid-Lipofuscinoses	13.2%
98	Hyperlipoproteinemia Type IV	12.9%
99	Hyperlipoproteinemia Type V	12.9%
100	Hepatic Encephalopathy	12.9%
101	Hypolipoproteinemias	12.8%
102	Dermatitis, Phototoxic	12.8%
103	Pityriasis Lichenoides et Varioliformis Acuta	12.8%
104	Pityriasis Lichenoides	12.8%
105	Phototoxicity	12.8%
106	Familial Hypophosphatemic Rickets	12.5%
107	Refsum Disease	12.4%
108	Acid-Base Imbalance	12.3%
109	Breast Diseases	12.3%
110	Calcium Metabolism Disorders	12.3%
111	Dermatitis	12.3%
112	Iron Metabolism Disorders	12.3%
113	Exanthema	12.3%
114	Facial Dermatoses	12.3%
115	Hair Diseases	12.3%
116	Hand Dermatoses	12.3%
117	keratoacanthoma	12.3%
118	Keratosis	12.3%
119	Nail Diseases	12.3%
120	Phosphorus Metabolism Disorders	12.3%
121	Photosensitivity Disorders	12.3%
122	Prurigo	12.3%
123	Pyoderma	12.3%
124	Rosacea	12.3%
125	Sebaceous Gland Diseases	12.3%
126	Skin Diseases, Vesiculobullous	12.3%
127	Skin Ulcer	12.3%
128	Sweat Gland Diseases	12.3%
129	Water-Electrolyte Imbalance	12.3%
130	Lipid Metabolism Disorders	12.3%
131	Skin Diseases, Papulosquamous	12.3%
132	Skin Diseases, Vascular	12.3%
133	Acneiform Eruptions	12.3%
134	Ocular Rosacea	12.3%
135	Subcorneal pustular dermatosis	12.3%
136	Mitochondrial Diseases	12.3%
137	Glucose Metabolism Disorders	12.3%
138	Erythematotelangiectatic Rosacea	12.3%
139	Papulopustular Rosacea	12.3%
140	Chronic Actinic Dermatitis	12.3%
141	Tay-Sachs Disease	12.3%
142	Hepatitis, Chronic	12.2%
143	Liver Failure	12.2%
144	Non-alcoholic Fatty Liver Disease	12.2%
145	Chronic active hepatitis	12.2%
146	Hyperlipidemia, Familial Combined	12.1%
147	Mucopolysaccharidosis III	12%
148	Chemical and Drug Induced Liver Injury	11.9%
149	Hepatitis B, Chronic	11.8%
150	Hepatitis C, Chronic	11.8%
151	Niemann-Pick Disease, Type C	11.8%
152	Adiposis Dolorosa	11.7%
153	Foot Ulcer	11.7%
154	Hyperlipoproteinemia Type III	11.7%
155	Panniculitis, Lupus Erythematosus	11.7%
156	Dermatitis Herpetiformis	11.7%
157	Hepatorenal Syndrome	11.6%
158	Sebaceous Gland Neoplasms	11.5%
159	Aicardi's syndrome	11.2%
160	Dermatitis, Photoallergic	11.2%
161	Fragile X Syndrome	11%
162	Rickets	10.9%
163	CHARGE Syndrome	10.7%
164	Angioedemas, Hereditary	10.7%
165	Erythema Induratum	10.6%
166	Osteogenesis Imperfecta	10.6%
167	Foot Diseases	10.6%
168	Neoplastic Syndromes, Hereditary	10.6%
169	Hypoalphalipoproteinemias	10.6%
170	Hepatitis, Animal	10.5%
171	Hepatitis, Viral, Human	10.5%
172	Nesidioblastosis	10.4%
173	Osteopenia	10.3%
174	Skin Diseases, Infectious	10.3%
175	Skin Neoplasms	10.3%
176	Pigmentation Disorders	10.3%
177	Brain Diseases, Metabolic	10.2%
178	Multiple Epiphyseal Dysplasia	10.2%
179	Osteochondrodysplasias	10.2%
180	Pelger-Huet Anomaly	10.2%
181	Pruritus	10.2%
182	Erythema	10.2%
183	Necrolytic Migratory Erythema	10.2%
184	Cutaneous Fistula	10.2%
185	Myasthenic Syndromes, Congenital	10.2%
186	Nephrogenic Fibrosing Dermopathy	10.2%
187	Nephrogenic Systemic Fibrosis	10.2%
188	Dermatomyositis	10.1%
189	Zollinger-Ellison syndrome	10.1%
190	Achlorhydria	10.1%
191	Liver Cirrhosis, Experimental	10.1%
192	Liver Failure, Acute	10.1%
193	End Stage Liver Disease	10.1%
194	Anemia, Sickle Cell	10%
195	Thalassemia	10%
196	Alkaptonuria	10%
197	Glycogen Storage Disease	10%
198	Hypophosphatasia	10%
199	Dermatitis, Irritant	10%
200	Hepatocellular Adenoma	10%
201	Acne Conglobata	10%
202	Propionic acidemia	10%
203	Dihydropyrimidine Dehydrogenase Deficiency	10%
204	Cystinosis	10%
205	Muscular Dystrophy, Duchenne	10%
206	Urticaria Pigmentosa	10%
207	Fanconi Anemia	10%
208	Peutz-Jeghers Syndrome	9.9%
209	Renal tubular acidosis	9.9%
210	Beckwith-Wiedemann Syndrome	9.6%
211	Wolf-Hirschhorn Syndrome	9.6%
212	Marfan Syndrome	9.5%
213	Celiac Disease	9.5%
214	Sprue, Tropical	9.5%
215	Steatorrhea	9.5%
216	Sprue	9.5%
217	Canavan Disease	9.4%
218	Alexander Disease	9.4%
219	Ataxia Telangiectasia	9.2%
220	Pruritus Ani	9.2%
221	Alstrom Syndrome	9.1%
222	Massive Hepatic Necrosis	9%
223	Dwarfism	9%
224	Optic Atrophy, Hereditary, Leber	9%
225	Bloom Syndrome	9%
226	Lupus Erythematosus, Discoid	9%
227	Scleroderma, Limited	9%
228	Liver Neoplasms, Experimental	9%
229	Toxic Epidermal Necrolysis	8.9%
230	Stevens-Johnson Syndrome	8.9%
231	HIV-Associated Lipodystrophy Syndrome	8.9%
232	Erythema Infectiosum	8.9%
233	Adenomatous Polyposis Coli	8.8%
234	Exanthema Subitum	8.8%
235	Dermatitis, Occupational	8.8%
236	Esophageal Atresia	8.7%
237	Fascioliasis	8.7%
238	Intestinal Atresia	8.7%
239	Erythema Nodosum	8.7%
240	Echinococcosis, Hepatic	8.7%
241	Mastocytosis	8.7%
242	Muscular Dystrophy	8.7%
243	Chemical and Drug Induced Liver Injury, Chronic	8.7%
244	MELAS Syndrome	8.6%
245	Dermatitis, Allergic Contact	8.6%
246	Proctocolitis	8.6%
247	Prader-Willi Syndrome	8.5%
248	Rett Syndrome	8.5%
249	Smith-Magenis syndrome	8.5%
250	Autoimmune hepatitis	8.5%
251	Biliary Tract Diseases	8.5%
252	Gastrointestinal Diseases	8.5%
253	Pancreatic Diseases	8.5%
254	CREST Syndrome	8.4%
255	Cri-du-Chat Syndrome	8.4%
256	Down Syndrome	8.4%
257	Trisomy 21	8.4%
258	Diaper Rash	8.3%
259	Glycogen Storage Disease Type I	8.3%
260	Glycogen Storage Disease Type V	8.3%
261	Osteomalacia	8.3%
262	Colorectal Neoplasms	8.2%
263	Kartagener Syndrome	8.2%
264	Acidosis	8.1%
265	Alkalosis	8.1%
266	Amyloidosis	8.1%
267	Anhidrosis	8.1%
268	Calcinosis	8.1%
269	Cholesteatoma	8.1%
270	Pressure Ulcer	8.1%
271	Folliculitis	8.1%
272	Foot Dermatoses	8.1%
273	Gynecomastia	8.1%
274	Hyperglycemia	8.1%
275	Hyperinsulinism	8.1%
276	Hyperkalemia	8.1%
277	Hypernatremia	8.1%
278	Hypertrichosis	8.1%
279	Hypoglycemia	8.1%
280	Hypohidrosis	8.1%
281	Hypokalemia	8.1%
282	Hyponatremia	8.1%
283	Hypotrichosis	8.1%
284	Leg Ulcer	8.1%
285	Miliaria	8.1%
286	Parakeratosis	8.1%
287	Parapsoriasis	8.1%
288	Familial Mediterranean Fever	8.1%
289	Pityriasis	8.1%
290	Psoriasis	8.1%
291	Xanthomatosis	8.1%
292	Sweet Syndrome	8.1%
293	Hidradenitis	8.1%
294	Onycholysis	8.1%
295	Hypophosphatemia	8.1%
296	Miliaria Rubra	8.1%
297	Hyperpigmentation	8.1%
298	Lichenoid Eruptions	8.1%
299	Metabolic acidosis	8.1%
300	Dyslipidemias	8.1%
301	Chloracne	8.1%
302	Iron Overload	8.1%
303	Xanthoma	8.1%
304	Tinea Capitis	8.1%
305	Onychomycosis	8.1%
306	Glycosuria, Renal	8%
307	Wiskott-Aldrich Syndrome	8%
308	Holoprosencephaly	7.9%
309	Gastrointestinal Neoplasms	7.8%
310	Diabetic Ketoacidosis	7.8%
311	Pancreatic Fistula	7.8%
312	Ecthyma	7.7%
313	Mitochondrial Encephalomyopathies	7.7%
314	Friedreich Ataxia	7.7%
315	Antley-Bixler Syndrome Phenotype	7.7%
316	Choledochal Cyst	7.7%
317	Autoimmune Lymphoproliferative Syndrome	7.7%
318	Familial Periodic Paralysis	7.6%
319	Bile Duct Neoplasms	7.5%
320	gallbladder neoplasm	7.5%
321	Intestinal Neoplasms	7.5%
322	Stomach Neoplasms	7.5%
323	Hepatitis, Viral, Animal	7.5%
324	Renal Aminoacidurias	7.4%
325	Fanconi Syndrome	7.4%
326	Pseudohypoaldosteronism	7.4%
327	Liddle Syndrome	7.4%
328	Sickle Cell Trait	7.4%
329	Hepatitis E	7.3%
330	Cecal Neoplasms	7.3%
331	Duodenal Neoplasms	7.3%
332	Hepatitis B	7.2%
333	Hepatitis C	7.2%
334	Myotonic Dystrophy	7.2%
335	Hepatitis A	7.2%
336	Granuloma Annulare	7.2%
337	Duodenitis	7.1%
338	Ileitis	7.1%
339	Erosive Duodenitis	7.1%
340	Digestive System Neoplasms	7.1%
341	Connective Tissue Diseases	7%
342	Deformity	7%
343	Nutrition Disorders	7%
344	Diabetes Mellitus	7%
345	Anus Neoplasms	7%
346	Sigmoid Neoplasms	7%
347	Rubinstein-Taybi Syndrome	6.9%
348	Tuberous Sclerosis	6.9%
349	Mesenteric vascular insufficiency	6.9%
350	Peritoneal Neoplasms	6.8%
351	Acantholysis	6.8%
352	Anus, Imperforate	6.8%
353	Breast Cyst	6.8%
354	Dehydration	6.8%
355	Actinic keratosis	6.8%
356	Mesenteric Panniculitis	6.8%
357	Panniculitis, Peritoneal	6.8%
358	Pemphigoid, Benign Mucous Membrane	6.8%
359	Pemphigus	6.8%
360	Piedra	6.8%
361	Sunburn	6.8%
362	Water Intoxication	6.8%
363	Anorectal Malformations	6.8%
364	Kallmann Syndrome	6.8%
365	Mesenteric Vascular Occlusion	6.8%
366	Intestinal Fistula	6.8%
367	Enterocutaneous Fistula	6.8%
368	Argyria	6.7%
369	Dysentery	6.7%
370	Enteritis	6.7%
371	Enterocolitis	6.7%
372	Esophagitis	6.7%
373	Gastritis	6.7%
374	Hirsutism	6.7%
375	Inflammatory Bowel Diseases	6.7%
376	Lactation Disorder	6.7%
377	Mastitis	6.7%
378	Osteoporosis	6.7%
379	Urticaria	6.7%
380	Bone Demineralization, Pathologic	6.7%
381	Post-Traumatic Osteoporosis	6.7%
382	Cholecystolithiasis	6.7%
383	Gout	6.7%
384	Pruritus Vulvae	6.7%
385	Esophageal Neoplasms	6.7%
386	Mastocytoma	6.7%
387	Polycystic Kidney Diseases	6.7%
388	Williams Syndrome	6.7%
389	Hidradenitis Suppurativa	6.6%
390	Rectal Fistula	6.6%
391	Anal Fistula	6.6%
392	Primary Ciliary Dyskinesia	6.6%
393	Appendiceal Neoplasms	6.5%
394	Colonic Neoplasms	6.5%
395	Rectal Neoplasms	6.5%
396	Pouchitis	6.4%
397	Erythema Chronicum Migrans	6.3%
398	Hypokalemic periodic paralysis	6.2%
399	Colitis	6.1%
400	Duodenogastric Reflux	6.1%
401	Peptic Ulcer	6.1%
402	Proctitis	6.1%
403	Choledocholithiasis	6.1%
404	Cystinuria	6.1%
405	Pancreatic Neoplasm	6.1%
406	Retinal Dysplasia	6.1%
407	Aniridia	6.1%
408	Acidosis, Lactic	6%
409	Calciphylaxis	6%
410	Hemosiderosis	6%
411	Ketosis	6%
412	Lichen Planus	6%
413	Melanosis	6%
414	Chloasma	6%
415	Pityriasis Rosea	6%
416	Pityriasis Rubra Pilaris	6%
417	Vitiligo	6%
418	Ketonuria	6%
419	Lichen Nitidus	6%
420	Ketoacidosis	6%
421	Ketonemia	6%
422	Vascular calcification	6%
423	Acute Chest Syndrome	6%
424	Tinea Pedis	6%
425	Renal Osteodystrophy	6%
426	Renal rickets	6%
427	HIV Wasting Syndrome	5.9%
428	Fetal Diseases	5.9%
429	Dermatomycoses	5.8%
430	Mucocutaneous Lymph Node Syndrome	5.8%
431	Skin Diseases, Bacterial	5.8%
432	Mitochondrial Myopathies	5.8%
433	Retinitis Pigmentosa	5.8%
434	Myelinolysis, Central Pontine	5.8%
435	Pigmentary retinopathy	5.8%
436	Drug Eruptions	5.8%
437	Livedo Reticularis	5.8%
438	Malignant Atrophic Papulosis	5.8%
439	Glycosuria	5.7%
440	Chronic granulomatous disease	5.7%
441	Gastrointestinal Stromal Tumors	5.7%
442	Polyarteritis Nodosa	5.7%
443	Takayasu Arteritis	5.7%
444	Welander Distal Myopathy	5.7%
445	Crohn Disease	5.6%
446	Duodenal Obstruction	5.6%
447	Enterocolitis, Neutropenic	5.6%
448	Necrotizing Enterocolitis	5.6%
449	Arthritis, Gouty	5.5%
450	Bile Duct Diseases	5.5%
451	Cholelithiasis	5.5%
452	Chylous Ascites	5.5%
453	Esophageal Diseases	5.5%
454	Gastroenteritis	5.5%
455	Intestinal Diseases	5.5%
456	Pancreatic Insufficiency	5.5%
457	Pancreatitis	5.5%
458	Pneumoperitoneum	5.5%
459	Stomach Diseases	5.5%
460	Mycetoma	5.4%
461	Kernicterus	5.4%
462	Appendicitis	5.3%
463	Duodenal Ulcer	5.3%
464	Peptic Ulcer Perforation	5.3%
465	Gastric ulcer	5.3%
466	Wernicke Encephalopathy	5.2%
467	Duane Retraction Syndrome	5.1%
468	Alopecia	5.1%
469	Sweating, Gustatory	5.1%
470	Androgenetic Alopecia	5.1%
471	Auriculotemporal Syndrome	5.1%
472	Acidosis, Respiratory	5%
473	Alkalosis, Respiratory	5%
474	Lice Infestations	5%
475	Varicose Ulcer	5%
476	Breast Neoplasms, Male	5%
477	Triple Negative Breast Neoplasms	5%
478	Myotonia Congenita	5%
479	Thrombasthenia	5%
480	Antithrombin III Deficiency	5%
481	Protein C Deficiency	5%
482	Acanthosis Nigricans	5%
483	Alopecia Areata	5%
484	Hypercholesterolemia	5%
485	Hyperlipoproteinemias	5%
486	Hypertriglyceridemia	5%
487	Lentigo	5%
488	Classical Lissencephalies and Subcortical Band Heterotopias	5%
489	Afibrinogenemia	5%
490	Dystonia Musculorum Deformans	5%
491	Factor VII Deficiency	5%
492	Factor X Deficiency	5%
493	Factor XII Deficiency	5%
494	Hemophilia A	5%
495	Insulin Resistance	5%
496	Osteoporosis, Postmenopausal	5%
497	Activated Protein C Resistance	5%
498	Factor II deficiency	5%
499	Factor VIII Deficiency	5%
500	Galactorrhea	5%
501	Factor V deficiency	5%
502	Factor XI Deficiency	5%
503	Hypoprothrombinemias	5%
504	Lafora Disease	5%
505	Unverricht-Lundborg Syndrome	5%
506	Anemia, Diamond-Blackfan	5%
507	Polycystic Kidney, Autosomal Dominant	4.9%
508	Colonic Pseudo-Obstruction	4.8%
509	Enterocolitis, Pseudomembranous	4.7%
510	pseudomembranous colitis	4.7%
511	Dysentery, Bacillary	4.7%
512	Pancreatic Cyst	4.6%
513	Meconium Aspiration Syndrome	4.6%
514	Multiple Endocrine Neoplasia	4.6%
515	Rift Valley Fever	4.6%
516	Colitis, Ischemic	4.6%
517	Gastrointestinal Hemorrhage	4.5%
518	Hemoperitoneum	4.5%
519	Peritonitis	4.5%
520	Peritoneal Fibrosis	4.5%
521	Encapsulating Peritoneal Sclerosis	4.5%
522	Kearns-Sayre syndrome	4.5%
523	Biliary Fistula	4.5%
524	Gastric Fistula	4.5%
525	Tuberculosis, Gastrointestinal	4.5%
526	Congenital Hypothyroidism	4.5%
527	Charcot-Marie-Tooth Disease	4.4%
528	Gestational Diabetes	4.4%
529	Latent Autoimmune Diabetes in Adults	4.4%
530	Diabetes Mellitus, Experimental	4.3%
531	Larva Migrans	4.3%
532	Leishmaniasis	4.3%
533	Molluscum Contagiosum	4.3%
534	Angioedema	4.3%
535	Onchocerciasis	4.3%
536	Chromoblastomycosis	4.3%
537	Dermatophytosis	4.3%
538	Nephrocalcinosis	4.3%
539	Sporotrichosis	4.3%
540	Tetany	4.3%
541	Tinea	4.3%
542	Tinea Versicolor	4.3%
543	Trichophytosis	4.3%
544	Hyalohyphomycosis	4.3%
545	Acute Generalized Exanthematous Pustulosis	4.3%
546	Cerebral Amyloid Angiopathy	4.2%
547	Mobius Syndrome	4.2%
548	Lichen Planus, Oral	4.2%
549	Abdominal Cramps	4.1%
550	Abnormalities, Drug-Induced	4.1%
551	Amniotic Band Syndrome	4.1%
552	Asphyxia Neonatorum	4.1%
553	Child Nutrition Disorders	4.1%
554	Collagen Diseases	4.1%
555	Hypervitaminosis A	4.1%
556	Infant Nutrition Disorders	4.1%
557	Infant, Premature, Diseases	4.1%
558	Mixed Connective Tissue Disease	4.1%
559	Situs Inversus	4.1%
560	Malnutrition	4.1%
561	Mucinoses	4.1%
562	Infantile Colic	4.1%
563	Basal Cell Nevus Syndrome	4.1%
564	Cecal Diseases	4.1%
565	Cholangitis	4.1%
566	Cholecystitis	4.1%
567	Cholestasis	4.1%
568	Colonic Diseases	4.1%
569	Common Bile Duct Diseases	4.1%
570	Esophageal Stenosis	4.1%
571	Ileal Diseases	4.1%
572	Intestinal Obstruction	4.1%
573	Intestinal Perforation	4.1%
574	Jejunal Diseases	4.1%
575	Pneumatosis Cystoides Intestinalis	4.1%
576	Rectal Diseases	4.1%
577	Gastric Dilatation	4.1%
578	Pancreatitis, Chronic	4.1%
579	Gastric outlet obstruction	4.1%
580	Cronkhite-Canada Syndrome	4.1%
581	Intestinal Polyposis	4.1%
582	Noonan Syndrome	4%
583	Warts	3.8%
584	Primary amyloidosis	3.8%
585	Candidiasis, Chronic Mucocutaneous	3.7%
586	Cutaneous Candidiasis	3.7%
587	Erysipelas	3.7%
588	Serum Sickness	3.7%
589	Staphylococcal Skin Infections	3.7%
590	Erythrasma	3.7%
591	Carcinoma, Lobular	3.7%
592	Klinefelter Syndrome	3.7%
593	Arthritis, Psoriatic	3.7%
594	Huntington Disease	3.6%
595	Carcinoma, Pancreatic Ductal	3.6%
596	Giant Cell Arteritis	3.6%
597	Temporal Arteritis	3.6%
598	Leishmaniasis, Cutaneous	3.6%
599	Eczema Herpeticum	3.6%
600	Fusariosis	3.5%
601	Cartilage Diseases	3.5%
602	Eye Abnormalities	3.5%
603	Rheumatism	3.5%
604	Chondromalacia	3.5%
605	Cardiovascular Abnormalities	3.5%
606	Esophageal Perforation	3.5%
607	Intestinal Diseases, Parasitic	3.5%
608	Hydrops Fetalis	3.5%
609	Lupus Erythematosus, Systemic	3.4%
610	Turner Syndrome	3.4%
611	Lymphatic Abnormalities	3.4%
612	Overlap syndrome	3.4%
613	Congenital Microtia	3.4%
614	Anemia, Neonatal	3.4%
615	Barrett Esophagus	3.4%
616	Deglutition Disorders	3.4%
617	Persistent Fetal Circulation Syndrome	3.4%
618	Congenital diaphragmatic hernia	3.4%
619	Umbilical hernia	3.4%
620	Pancreatic Pseudocyst	3.4%
621	Gastric Antral Vascular Ectasia	3.4%
622	Cholestasis, Extrahepatic	3.4%
623	Biliary Dyskinesia	3.4%
624	Cholangitis, Sclerosing	3.4%
625	Colonic Diseases, Functional	3.4%
626	Esophageal motility disorders	3.4%
627	Fecal Incontinence	3.4%
628	Fecal Impaction	3.4%
629	Intussusception	3.4%
630	Mallory-Weiss Syndrome	3.4%
631	Megacolon	3.4%
632	Pyloric Stenosis	3.4%
633	Acalculous Cholecystitis	3.4%
634	Ileus	3.4%
635	Meconium ileus	3.4%
636	Peptic Ulcer Hemorrhage	3.4%
637	Gastroparesis	3.4%
638	Pancreatitis, Alcoholic	3.4%
639	Anencephaly	3.3%
640	Amyotrophic Lateral Sclerosis	3.3%
641	Multiple Endocrine Neoplasia Type 1	3.3%
642	Nephroblastoma	3.3%
643	insulinoma	3.3%
644	Gastrinoma	3.3%
645	Glucagonoma	3.3%
646	Hereditary Angioedema Type III	3.2%
647	Hereditary Angioedema Types I and II	3.2%
648	Epidermodysplasia Verruciformis	3.1%
649	Herpes Labialis	3.1%
650	Diabetic Foot	3.1%
651	Frontotemporal dementia	3.1%
652	Staphylococcal Scalded Skin Syndrome	3.1%
653	Laryngomalacia	3.1%
654	Urogenital Abnormalities	3%
655	Pectus carinatum	3%
656	Esophageal Achalasia	3%
657	Anal Fissure	3%
658	Intestinal Pseudo-Obstruction	3%
659	Irritable Bowel Syndrome	3%
660	Superior Mesenteric Artery Syndrome	3%
661	Emphysematous Cholecystitis	3%
662	Neurogenic Bowel	3%
663	Sphincter of Oddi Dysfunction	3%
664	Anal Ulcer	3%
665	Blastomycosis	3%
666	Neonatal Abstinence Syndrome	3%
667	Vipoma	3%
668	Maxillofacial Abnormalities	3%
669	Dural Arteriovenous Fistula	3%
670	Dextrocardia	2.9%
671	Fetal Growth Retardation	2.9%
672	Melena	2.9%
673	Fetal Hypoxia	2.9%
674	Congenital nystagmus	2.9%
675	Fetal Alcohol Spectrum Disorders	2.9%
676	Dupuytren Contracture	2.9%
677	Toxoplasmosis, Congenital	2.9%
678	Syphilis, Congenital	2.9%
679	Hematemesis	2.9%
680	Hemorrhoids	2.8%
681	Afferent Loop Syndrome	2.8%
682	Short Bowel Syndrome	2.8%
683	Rectocele	2.8%
684	Diverticulitis	2.8%
685	Dumping Syndrome	2.8%
686	Rectal Prolapse	2.8%
687	Condylomata Acuminata	2.8%
688	Rhinoscleroma	2.8%
689	Furunculosis	2.8%
690	furuncle	2.8%
691	carbuncle	2.8%
692	Impetigo	2.7%
693	Deficiency Diseases	2.7%
694	Prune Belly Syndrome	2.7%
695	Starvation	2.7%
696	Twins, Conjoined	2.7%
697	Scleromyxedema	2.7%
698	Refeeding Syndrome	2.7%
699	Waardenburg Syndrome	2.7%
700	Cellulitis	2.5%
701	Chorioamnionitis	2.5%
702	Bronchomalacia	2.5%
703	Tracheomalacia	2.5%
704	Giardiasis	2.4%
705	Diverticulum	2.4%
706	Diverticulosis	2.4%
707	Laryngopharyngeal Reflux	2.4%
708	Scimitar Syndrome	2.4%
709	Denys-Drash Syndrome	2.3%
710	Acrocephalosyndactylia	2.3%
711	Microcephaly	2.3%
712	Macrocephaly	2.3%
713	Anophthalmos	2.3%
714	Hydranencephaly	2.3%
715	Microphthalmos	2.3%
716	Neural Tube Defects	2.3%
717	Paralysis, Obstetric	2.3%
718	Retinopathy of Prematurity	2.3%
719	Tietze's Syndrome	2.3%
720	Tethered Cord Syndrome	2.3%
721	Orbital Cellulitis	2.3%
722	Iniencephaly	2.3%
723	Craniorachischisis	2.3%
724	Limb Deformities, Congenital	2.3%
725	Exencephaly	2.3%
726	Septo-Optic Dysplasia	2.3%
727	Craniofacial Abnormalities	2.3%
728	Cortical Dysplasia	2.3%
729	Myxoid cyst	2.3%
730	Malformations of Cortical Development	2.3%
731	Myxedema	2.2%
732	Abnormalities, Radiation-Induced	2.2%
733	Bronchopulmonary Dysplasia	2.2%
734	Craniosynostosis	2.2%
735	Syndactyly	2.2%
736	Brachycephaly	2.2%
737	Porencephaly	2.1%
738	Kwashiorkor	2%
739	Magnesium Deficiency	2%
740	Potassium Deficiency	2%
741	Protein Deficiency	2%
742	Avitaminosis	2%
743	Ophthalmia Neonatorum	2%
744	Cleft Palate	2%
745	Blepharophimosis	2%
746	Laryngostenosis	2%
747	Mouth Abnormalities	2%
748	Osteochondritis	2%
749	Polymyalgia Rheumatica	2%
750	Respiratory Distress Syndrome, Newborn	2%
751	Horseshoe Kidney	1.9%
752	Pectus excavatum	1.9%
753	Klippel-Feil Syndrome	1.9%
754	Gastroschisis	1.9%
755	Synostosis	1.9%
756	Lymphangiectasis, Intestinal	1.9%
757	Keloid	1.9%
758	Jaw Abnormalities	1.8%
759	Poland Syndrome	1.8%
760	Arthrogryposis	1.7%
761	Choanal Atresia	1.7%
762	Tracheobronchomegaly	1.7%
763	Laryngocele	1.7%
764	Rheumatoid Arthritis	1.7%
765	Hermaphroditism	1.7%
766	Disorders of Sex Development	1.7%
767	Juvenile arthritis	1.7%
768	Cryptorchidism	1.7%
769	Hypospadias	1.7%
770	Central Nervous System Cysts	1.7%
771	Cryptosporidiosis	1.7%
772	Dandy-Walker Syndrome	1.7%
773	Amelia	1.7%
774	Arachnodactyly	1.7%
775	Ectopia Cordis	1.7%
776	Ectromelia	1.7%
777	Hemimelia	1.7%
778	Meningomyelocele	1.7%
779	Phocomelia	1.7%
780	Sirenomelia	1.7%
781	Spina Bifida	1.7%
782	Polydactyly	1.7%
783	Brachydactyly	1.7%
784	Plagiocephaly	1.7%
785	Lower Extremity Deformities, Congenital	1.7%
786	Upper Extremity Deformities, Congenital	1.7%
787	Single umbilical artery	1.7%
788	Ascorbic Acid Deficiency	1.7%
789	Vitamin A Deficiency	1.7%
790	Vitamin D Deficiency	1.7%
791	Vitamin E Deficiency	1.7%
792	Marasmus	1.7%
793	Leukomalacia, Periventricular	1.7%
794	POEMS Syndrome	1.7%
795	Lupus Nephritis	1.7%
796	Obesity	1.6%
797	Micrognathism	1.6%
798	Pierre Robin Syndrome	1.6%
799	Folic Acid Deficiency	1.5%
800	Pellagra	1.5%
801	Thiamine Deficiency	1.5%
802	Vitamin B 12 Deficiency	1.5%
803	Vitamin B 6 Deficiency	1.5%
804	Pyridoxine Deficiency	1.5%
805	Bladder Exstrophy	1.5%
806	Epispadias	1.5%
807	Multicystic Dysplastic Kidney	1.5%
808	Aortic coarctation	1.4%
809	Cor Triatriatum	1.4%
810	Coronary Vessel Anomalies	1.4%
811	Dental Enamel Hypoplasia	1.4%
812	Patent ductus arteriosus	1.4%
813	Ebstein Anomaly	1.4%
814	Heart Septal Defects	1.4%
815	Hyaline Membrane Disease	1.4%
816	Hypodontia	1.4%
817	Macrostomia	1.4%
818	Meningocele	1.4%
819	Microstomia	1.4%
820	Tetralogy of Fallot	1.4%
821	Transposition of Great Vessels	1.4%
822	Hypoplastic Left Heart Syndrome	1.4%
823	May-Thurner Syndrome	1.4%
824	Encephalocele	1.4%
825	Craniofacial Dysostosis	1.4%
826	Rheumatoid Nodule	1.4%
827	Retrognathia	1.4%
828	Wolff-Parkinson-White Syndrome	1.4%
829	Beriberi	1.4%
830	Obesity, Abdominal	1.4%
831	Dermal Sinus	1.4%
832	Spina Bifida Cystica	1.4%
833	Spina Bifida Occulta	1.4%
834	Lissencephaly	1.4%
835	Polymicrogyria	1.4%
836	Pachygyria	1.4%
837	Schizencephaly	1.4%
838	Periventricular Nodular Heterotopia	1.4%
839	Hyperandrogenism	1.4%
840	Prognathism	1.3%
841	Long QT Syndrome	1.3%
842	Platybasia	1.3%
843	Tricuspid Atresia	1.3%
844	Arrhythmogenic Right Ventricular Dysplasia	1.3%
845	Felty Syndrome	1.3%
846	Gonadal Dysgenesis	1.3%
847	Adrenogenital Syndrome	1.3%
848	Ovotesticular Disorders of Sex Development	1.3%
849	Pediatric Obesity	1.2%
850	Vitamin K Deficiency	1.2%
851	Aortopulmonary Septal Defect	1.2%
852	Double Outlet Right Ventricle	1.2%
853	Endocardial Cushion Defects	1.2%
854	Myocardial bridging	1.2%
855	Aorticopulmonary Septal Defect	1.2%
856	Anemia, Pernicious	1.2%
857	Rheumatoid Vasculitis	1.1%
858	Scurvy	1.1%
859	Truncus Arteriosus, Persistent	1.1%
860	Goldenhar Syndrome	1.1%
861	Mandibulofacial Dysostosis	1%
862	Romano-Ward Syndrome	1%
863	Sicca Syndrome	1%
864	Sjogren's Syndrome	1%
865	Talipes	0.9%
866	Lupus Vasculitis, Central Nervous System	0.9%
867	Congenital clubfoot	0.9%
868	Vertical Talus	0.9%
869	Arteriovenous fistula	0.8%
870	Subacute Combined Degeneration	0.8%

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