MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypolipoproteinemias

(UMLS:C0020623)

Definition:: Conditions with abnormally low levels of LIPOPROTEINS in the blood. This may involve any of the lipoprotein subclasses, including ALPHA-LIPOPROTEINS (high-density lipoproteins); BETA-LIPOPROTEINS (low-density lipoproteins); and PREBETA-LIPOPROTEINS (very-low-density lipoproteins).
UMLS ID:: C0020623
MeSH ID:: D007009

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.398.500

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.584.500.875|C18.452.648.398.500

Synonym(s)

Hypolipoproteinemias

Hypolipoproteinemia

Lack of fat in blood

Lipoprotein deficiencies

Lipoprotein deficiency

Lipoprotein deficiency disorder

deficiency lipoprotein

deficiency; lipoprotein

disorder; lipoprotein, deficiency

10.

hypolipoproteinemia

11.

lipoprotein deficiency

12.

lipoprotein; deficiency

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Atorvastatin	19240310	CTD
2	Niacin	View details 12767421 19131065 19240310 21045170	CTD
3	Norinyl	6631239	CTD
4	Rosuvastatin Calcium	12767421	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperlipoproteinemia Type IV	50.8%
2	Hyperlipoproteinemia Type V	50.8%
3	Smith-Lemli-Opitz Syndrome	50%
4	Hyperlipidemia, Familial Combined	49.9%
5	Hyperlipoproteinemia Type III	47.4%
6	Amino Acid Metabolism, Inborn Errors	33.3%
7	Carbohydrate Metabolism, Inborn Errors	33.3%
8	Metal Metabolism, Inborn Errors	33.3%
9	Progeria	33.3%
10	Lysosomal Storage Diseases	33.3%
11	Peroxisomal Disorders	33.3%
12	Brain Diseases, Metabolic, Inborn	32.2%
13	Neuronal Ceroid-Lipofuscinoses	31.8%
14	Leigh Disease	28.8%
15	Galactosemias	28.6%
16	Urea Cycle Disorders, Inborn	28.6%
17	Tyrosinemias	28.6%
18	Pseudohypoparathyroidism	28.6%
19	Gaucher Disease	28.1%
20	Wasting Syndrome	26.8%
21	Lipodystrophy	26.2%
22	Hyperphosphaturia	25.8%
23	Cytochrome-c Oxidase Deficiency	25.5%
24	Hyperhomocysteinemia	25.1%
25	Carbamoyl-Phosphate Synthase I Deficiency Disease	25%
26	Acid-Base Imbalance	24.8%
27	Calcium Metabolism Disorders	24.8%
28	Iron Metabolism Disorders	24.8%
29	Phosphorus Metabolism Disorders	24.8%
30	Water-Electrolyte Imbalance	24.8%
31	Mitochondrial Diseases	24.8%
32	Glucose Metabolism Disorders	24.8%
33	Glycogen storage disease type II	24.8%
34	Fabry Disease	24.5%
35	Xanthomatosis	24.4%
36	Xanthoma	24.4%
37	Lactose Intolerance	24.1%
38	Hypercalcemia	23.5%
39	Hypocalcemia	23.5%
40	Milk-Alkali Syndrome	23.5%
41	Tay-Sachs Disease	23.3%
42	Homocystinuria	23.2%
43	Niemann-Pick Disease, Type C	23%
44	Menkes Kinky Hair Syndrome	22.8%
45	Sjogren-Larsson Syndrome	22.6%
46	Alkaptonuria	21.9%
47	Glycogen Storage Disease	21.9%
48	Hypophosphatasia	21.9%
49	Propionic acidemia	21.9%
50	Dihydropyrimidine Dehydrogenase Deficiency	21.9%
51	Cystinosis	21.9%
52	Werner Syndrome	21.9%
53	Hypercholesterolemia	21.7%
54	Hyperlipoproteinemias	21.7%
55	Hypertriglyceridemia	21.7%
56	Adrenoleukodystrophy	21.4%
57	Zellweger Syndrome	20.8%
58	Hepatolenticular Degeneration	20.8%
59	Mucopolysaccharidosis III	20.4%
60	Refsum Disease	20.3%
61	Osteopenia	20.1%
62	Brain Diseases, Metabolic	19.9%
63	Lipomatosis	19.9%
64	Amyloid Neuropathies, Familial	19.7%
65	Familial Hypophosphatemic Rickets	18.9%
66	Renal tubular acidosis	18.5%
67	Mucopolysaccharidosis II	18.3%
68	Rickets	17.9%
69	Albinism	17.1%
70	Glycogen Storage Disease Type I	16.3%
71	Glycogen Storage Disease Type V	16.3%
72	Familial Periodic Paralysis	16%
73	Renal Aminoacidurias	15.6%
74	Fanconi Syndrome	15.6%
75	Pseudohypoaldosteronism	15.6%
76	Liddle Syndrome	15.6%
77	Ichthyosis, X-Linked	15.5%
78	Nutrition Disorders	15.4%
79	Glycosuria, Renal	14.8%
80	MELAS Syndrome	14.7%
81	Acidosis	14.6%
82	Alkalosis	14.6%
83	Amyloidosis	14.6%
84	Calcinosis	14.6%
85	Hyperglycemia	14.6%
86	Hyperinsulinism	14.6%
87	Hyperkalemia	14.6%
88	Hypernatremia	14.6%
89	Hypoglycemia	14.6%
90	Hypokalemia	14.6%
91	Hyponatremia	14.6%
92	Hypophosphatemia	14.6%
93	Metabolic acidosis	14.6%
94	Iron Overload	14.6%
95	Antley-Bixler Syndrome Phenotype	14.5%
96	Cockayne Syndrome	14.2%
97	Gout	14%
98	Congenital Hyperinsulinism	13.7%
99	Bloom Syndrome	13.7%
100	Adiposis Dolorosa	13%
101	Porphyrias, Hepatic	12.8%
102	Canavan Disease	12.8%
103	Alexander Disease	12.8%
104	Fanconi Anemia	12.5%
105	Lipid Metabolism Disorders	12.4%
106	Diabetes Mellitus	12.2%
107	Mitochondrial Encephalomyopathies	12.2%
108	Osteomalacia	12%
109	Dehydration	11.9%
110	Water Intoxication	11.9%
111	Achlorhydria	11.8%
112	Osteoporosis	11.8%
113	Bone Demineralization, Pathologic	11.8%
114	Post-Traumatic Osteoporosis	11.8%
115	Hypokalemic periodic paralysis	11.8%
116	Celiac Disease	11.7%
117	Sprue, Tropical	11.7%
118	Steatorrhea	11.7%
119	Sprue	11.7%
120	Cystinuria	11.6%
121	HIV-Associated Lipodystrophy Syndrome	11.5%
122	Diabetic Ketoacidosis	11.3%
123	Ataxia Telangiectasia	11%
124	Neoplastic Syndromes, Hereditary	10.3%
125	Arthritis, Gouty	10.3%
126	Mitochondrial Myopathies	9.9%
127	CHARGE Syndrome	9.9%
128	Multiple Epiphyseal Dysplasia	9.9%
129	Osteochondrodysplasias	9.9%
130	Pelger-Huet Anomaly	9.9%
131	Myasthenic Syndromes, Congenital	9.9%
132	Myelinolysis, Central Pontine	9.9%
133	Glycosuria	9.8%
134	Reye Syndrome	9.8%
135	HIV Wasting Syndrome	9.8%
136	Cystic Fibrosis	9.8%
137	Hepatic Encephalopathy	9.7%
138	Optic Atrophy, Hereditary, Leber	9.7%
139	Nesidioblastosis	9.7%
140	Friedreich Ataxia	9.7%
141	Acidosis, Lactic	9.7%
142	Calciphylaxis	9.7%
143	Hemosiderosis	9.7%
144	Ketosis	9.7%
145	Ketonuria	9.7%
146	Ketoacidosis	9.7%
147	Ketonemia	9.7%
148	Vascular calcification	9.7%
149	Aicardi's syndrome	9.3%
150	Xeroderma Pigmentosum	9.1%
151	Nail-Patella Syndrome	8.6%
152	Dwarfism	8.6%
153	Renal Osteodystrophy	8.5%
154	Renal rickets	8.5%
155	Necrobiosis Lipoidica Diabeticorum	8.4%
156	Anemia, Sickle Cell	8.4%
157	Thalassemia	8.4%
158	Muscular Dystrophy, Duchenne	8.4%
159	Variegate Porphyria	8.3%
160	Acute intermittent porphyria	8.3%
161	Porphyria Cutanea Tarda	8.3%
162	Child Nutrition Disorders	8.3%
163	Hypervitaminosis A	8.3%
164	Infant Nutrition Disorders	8.3%
165	Malnutrition	8.3%
166	Muscular Dystrophy	8.2%
167	Osteogenesis Imperfecta	8.2%
168	Wernicke Encephalopathy	8.2%
169	Beckwith-Wiedemann Syndrome	8.2%
170	Wolf-Hirschhorn Syndrome	8.2%
171	Fragile X Syndrome	8%
172	Acidosis, Respiratory	7.8%
173	Alkalosis, Respiratory	7.8%
174	Prader-Willi Syndrome	7.8%
175	Insulin Resistance	7.7%
176	Osteoporosis, Postmenopausal	7.7%
177	Kernicterus	7.7%
178	Deformity	7.7%
179	Familial Mediterranean Fever	7.3%
180	Dyslipidemias	7.3%
181	Autoimmune Lymphoproliferative Syndrome	7.2%
182	Smith-Magenis syndrome	7.1%
183	Cri-du-Chat Syndrome	7%
184	Down Syndrome	7%
185	Angioedemas, Hereditary	7%
186	Trisomy 21	7%
187	Alstrom Syndrome	6.8%
188	Kearns-Sayre syndrome	6.7%
189	Marfan Syndrome	6.7%
190	Gestational Diabetes	6.7%
191	Latent Autoimmune Diabetes in Adults	6.7%
192	Diabetes Mellitus, Experimental	6.6%
193	Wiskott-Aldrich Syndrome	6.5%
194	Nephrocalcinosis	6.5%
195	Tetany	6.5%
196	Hypolipoproteinemias	6.5%
197	Rett Syndrome	6.4%
198	Kartagener Syndrome	6.4%
199	Cerebral Amyloid Angiopathy	6.4%
200	Holoprosencephaly	6.2%
201	Fetal Diseases	6.2%
202	Ectodermal Dysplasia	6.2%
203	Aplasia Cutis Congenita	6.2%
204	Kallmann Syndrome	6%
205	Myotonic Dystrophy	5.9%
206	Primary amyloidosis	5.6%
207	Polycystic Kidney Diseases	5.6%
208	Williams Syndrome	5.6%
209	Rubinstein-Taybi Syndrome	5.6%
210	Sickle Cell Trait	5.5%
211	Tuberous Sclerosis	5.5%
212	Primary Ciliary Dyskinesia	5.4%
213	Retinal Dysplasia	5.1%
214	Aniridia	5%
215	Cutis Laxa	5%
216	Retinitis Pigmentosa	4.9%
217	Pigmentary retinopathy	4.9%
218	Epidermolysis Bullosa	4.9%
219	Amyotrophic Lateral Sclerosis	4.9%
220	Porokeratosis	4.9%
221	Keratoderma, Palmoplantar	4.9%
222	Chronic granulomatous disease	4.9%
223	Deficiency Diseases	4.9%
224	Starvation	4.9%
225	Refeeding Syndrome	4.9%
226	Welander Distal Myopathy	4.9%
227	Hypoalphalipoproteinemias	4.8%
228	Acute Chest Syndrome	4.4%
229	CREST Syndrome	4.3%
230	Duane Retraction Syndrome	4.3%
231	Meconium Aspiration Syndrome	4.2%
232	Peutz-Jeghers Syndrome	4.2%
233	Myotonia Congenita	4.2%
234	Thrombasthenia	4.2%
235	Antithrombin III Deficiency	4.2%
236	Protein C Deficiency	4.2%
237	Afibrinogenemia	4.2%
238	Dystonia Musculorum Deformans	4.2%
239	Factor VII Deficiency	4.2%
240	Factor X Deficiency	4.2%
241	Factor XII Deficiency	4.2%
242	Hemophilia A	4.2%
243	Activated Protein C Resistance	4.2%
244	Factor II deficiency	4.2%
245	Factor VIII Deficiency	4.2%
246	Factor V deficiency	4.2%
247	Factor XI Deficiency	4.2%
248	Hypoprothrombinemias	4.2%
249	Lafora Disease	4.2%
250	Unverricht-Lundborg Syndrome	4.2%
251	Anemia, Diamond-Blackfan	4.1%
252	Abdominal Cramps	4.1%
253	Abnormalities, Drug-Induced	4.1%
254	Amniotic Band Syndrome	4.1%
255	Asphyxia Neonatorum	4.1%
256	Infant, Premature, Diseases	4.1%
257	Situs Inversus	4.1%
258	Infantile Colic	4.1%
259	Frontotemporal dementia	4.1%
260	Pseudoxanthoma Elasticum	4%
261	Multiple Endocrine Neoplasia	3.8%
262	Xeroderma	3.8%
263	Mobius Syndrome	3.8%
264	Congenital Hypothyroidism	3.7%
265	Dermatitis, Atopic	3.7%
266	Polycystic Kidney, Autosomal Dominant	3.7%
267	Classical Lissencephalies and Subcortical Band Heterotopias	3.5%
268	Eye Abnormalities	3.4%
269	Cardiovascular Abnormalities	3.4%
270	Hyperkeratosis, Epidermolytic	3.4%
271	Skin Abnormalities	3.4%
272	Lymphatic Abnormalities	3.4%
273	Congenital Microtia	3.4%
274	Anemia, Neonatal	3.3%
275	Persistent Fetal Circulation Syndrome	3.3%
276	Behcet Syndrome	3.3%
277	Congenital diaphragmatic hernia	3.3%
278	Umbilical hernia	3.3%
279	Basal Cell Nevus Syndrome	3.3%
280	Charcot-Marie-Tooth Disease	3.2%
281	Kwashiorkor	3.2%
282	Magnesium Deficiency	3.2%
283	Papillon-Lefevre Disease	3.2%
284	Potassium Deficiency	3.2%
285	Protein Deficiency	3.2%
286	Avitaminosis	3.2%
287	Huntington Disease	2.9%
288	Urogenital Abnormalities	2.9%
289	Neonatal Abstinence Syndrome	2.8%
290	Fetal Growth Retardation	2.8%
291	Obesity	2.8%
292	Fetal Hypoxia	2.7%
293	Congenital nystagmus	2.7%
294	Fetal Alcohol Spectrum Disorders	2.7%
295	Toxoplasmosis, Congenital	2.7%
296	Anencephaly	2.7%
297	Syphilis, Congenital	2.7%
298	Nephroblastoma	2.7%
299	Hydrops Fetalis	2.5%
300	Multiple Endocrine Neoplasia Type 1	2.4%
301	Prune Belly Syndrome	2.4%
302	Twins, Conjoined	2.4%
303	Waardenburg Syndrome	2.4%
304	Adenomatous Polyposis Coli	2.4%
305	Klinefelter Syndrome	2.4%
306	Ascorbic Acid Deficiency	2.4%
307	Vitamin A Deficiency	2.4%
308	Vitamin D Deficiency	2.4%
309	Vitamin E Deficiency	2.4%
310	Marasmus	2.4%
311	Chorioamnionitis	2.4%
312	Maxillofacial Abnormalities	2.4%
313	Dural Arteriovenous Fistula	2.4%
314	Dextrocardia	2.3%
315	Turner Syndrome	2.2%
316	Obesity, Abdominal	2.1%
317	Abnormalities, Radiation-Induced	2.1%
318	Folic Acid Deficiency	2%
319	Pellagra	2%
320	Thiamine Deficiency	2%
321	Vitamin B 12 Deficiency	2%
322	Vitamin B 6 Deficiency	2%
323	Pyridoxine Deficiency	2%
324	Anophthalmos	2%
325	Anus, Imperforate	2%
326	Hydranencephaly	2%
327	Microphthalmos	2%
328	Neural Tube Defects	2%
329	Paralysis, Obstetric	2%
330	Retinopathy of Prematurity	2%
331	Tethered Cord Syndrome	2%
332	Iniencephaly	2%
333	Craniorachischisis	2%
334	Limb Deformities, Congenital	2%
335	Exencephaly	2%
336	Septo-Optic Dysplasia	2%
337	Craniofacial Abnormalities	2%
338	Cortical Dysplasia	2%
339	Malformations of Cortical Development	2%
340	Anorectal Malformations	2%
341	Bronchopulmonary Dysplasia	1.9%
342	Scimitar Syndrome	1.9%
343	Pediatric Obesity	1.8%
344	Ophthalmia Neonatorum	1.8%
345	Beriberi	1.8%
346	Blepharophimosis	1.7%
347	Laryngostenosis	1.7%
348	Mouth Abnormalities	1.7%
349	Respiratory Distress Syndrome, Newborn	1.7%
350	Esophageal Atresia	1.7%
351	Intestinal Atresia	1.7%
352	Horseshoe Kidney	1.7%
353	Pectus excavatum	1.7%
354	Klippel-Feil Syndrome	1.6%
355	Gastroschisis	1.6%
356	Synostosis	1.6%
357	Acrodermatitis	1.6%
358	Lymphangiectasis, Intestinal	1.6%
359	Gianotti-Crosti Syndrome	1.6%
360	Vitamin K Deficiency	1.6%
361	Craniosynostosis	1.6%
362	Syndactyly	1.6%
363	Brachycephaly	1.6%
364	Microcephaly	1.6%
365	Macrocephaly	1.6%
366	Denys-Drash Syndrome	1.6%
367	Acrocephalosyndactylia	1.5%
368	Noonan Syndrome	1.5%
369	Arthrogryposis	1.4%
370	Choanal Atresia	1.4%
371	Tracheobronchomegaly	1.4%
372	Laryngocele	1.4%
373	Anemia, Pernicious	1.4%
374	Choledochal Cyst	1.4%
375	Hermaphroditism	1.4%
376	Disorders of Sex Development	1.4%
377	Cryptorchidism	1.4%
378	Hypospadias	1.4%
379	Central Nervous System Cysts	1.4%
380	Dandy-Walker Syndrome	1.4%
381	Leukomalacia, Periventricular	1.4%
382	POEMS Syndrome	1.4%
383	Porencephaly	1.4%
384	Scurvy	1.3%
385	Amelia	1.3%
386	Arachnodactyly	1.3%
387	Ectopia Cordis	1.3%
388	Ectromelia	1.3%
389	Hemimelia	1.3%
390	Meningomyelocele	1.3%
391	Phocomelia	1.3%
392	Sirenomelia	1.3%
393	Spina Bifida	1.3%
394	Polydactyly	1.3%
395	Brachydactyly	1.3%
396	Plagiocephaly	1.3%
397	Lower Extremity Deformities, Congenital	1.3%
398	Upper Extremity Deformities, Congenital	1.3%
399	Single umbilical artery	1.3%
400	Cleft Palate	1.3%
401	Jaw Abnormalities	1.3%
402	Laryngomalacia	1.3%
403	Pectus carinatum	1.3%
404	Bladder Exstrophy	1.2%
405	Epispadias	1.2%
406	Multicystic Dysplastic Kidney	1.2%
407	Poland Syndrome	1.2%
408	Aortic coarctation	1.1%
409	Cor Triatriatum	1.1%
410	Coronary Vessel Anomalies	1.1%
411	Dental Enamel Hypoplasia	1.1%
412	Patent ductus arteriosus	1.1%
413	Ebstein Anomaly	1.1%
414	Heart Septal Defects	1.1%
415	Hyaline Membrane Disease	1.1%
416	Hypodontia	1.1%
417	Macrostomia	1.1%
418	Meningocele	1.1%
419	Microstomia	1.1%
420	Tetralogy of Fallot	1.1%
421	Transposition of Great Vessels	1.1%
422	Hypoplastic Left Heart Syndrome	1.1%
423	May-Thurner Syndrome	1.1%
424	Encephalocele	1.1%
425	Craniofacial Dysostosis	1.1%
426	Wolff-Parkinson-White Syndrome	1.1%
427	Micrognathism	1%
428	Pierre Robin Syndrome	1%
429	Dermal Sinus	1%
430	Spina Bifida Cystica	1%
431	Spina Bifida Occulta	1%
432	Lissencephaly	1%
433	Polymicrogyria	1%
434	Pachygyria	1%
435	Schizencephaly	1%
436	Periventricular Nodular Heterotopia	1%
437	Long QT Syndrome	0.9%
438	Platybasia	0.9%
439	Tricuspid Atresia	0.9%
440	Arrhythmogenic Right Ventricular Dysplasia	0.9%
441	Subacute Combined Degeneration	0.9%
442	Gonadal Dysgenesis	0.9%
443	Bronchomalacia	0.9%
444	Adrenogenital Syndrome	0.9%
445	Tracheomalacia	0.9%
446	Ovotesticular Disorders of Sex Development	0.9%
447	Retrognathia	0.9%
448	Hyperandrogenism	0.9%
449	Prognathism	0.8%
450	Aortopulmonary Septal Defect	0.8%
451	Double Outlet Right Ventricle	0.8%
452	Endocardial Cushion Defects	0.8%
453	Myocardial bridging	0.8%
454	Aorticopulmonary Septal Defect	0.8%
455	Mandibulofacial Dysostosis	0.7%
456	Romano-Ward Syndrome	0.7%
457	Truncus Arteriosus, Persistent	0.7%
458	Goldenhar Syndrome	0.7%
459	Talipes	0.6%
460	Arteriovenous fistula	0.5%
461	Congenital clubfoot	0.5%
462	Vertical Talus	0.5%

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