MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pseudoxanthoma Elasticum

(UMLS:C0033847)

Definition:: An inherited disorder of connective tissue with extensive degeneration and calcification of ELASTIC TISSUE primarily in the skin, eye, and vasculature. At least two forms exist, autosomal recessive and autosomal dominant. This disorder is caused by mutations of one of the ATP-BINDING CASSETTE TRANSPORTERS. Patients are predisposed to MYOCARDIAL INFARCTION and GASTROINTESTINAL HEMORRHAGE.
UMLS ID:: C0033847
MeSH ID:: D011561

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.454.530

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.463.515.530

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.831.766|C16.320.850.750

Classification 4:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.766|C17.800.804.766|C17.800.827.750

Synonym(s)

Pseudoxanthoma Elasticum

ELASTORRHEXIS, SYSTEMIC, OF TOURAINE

ELASTOSIS DYSTROPHICA SYNDROME

Groenblad-Strandberg syndrome

PSEUDOXANTHOMA ELASTICUM

PXE - Pseudoxanthoma elasticum

Pseudoxanthoma elasticum

elasticum pseudoxanthoma

pseudoxanthoma elasticum

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cyclosporine	FAERS: 1		US FAERS
2	Penicillamine	FAERS: 1		US FAERS
3	Ranitidine	FAERS: 1		US FAERS
4	Warfarin	FAERS: 1		US FAERS
5	apremilast	FAERS: 1		US FAERS
6	Ascorbic Acid		17845175	CTD
7	Vitamin E		17845175	CTD
8	Vitamin K		25758222	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Epidermolysis Bullosa	51.8%
2	Xeroderma Pigmentosum	48.3%
3	Ectodermal Dysplasia	47.9%
4	Aplasia Cutis Congenita	47.9%
5	Ichthyosis, X-Linked	40.5%
6	Dermatitis, Atopic	38.4%
7	Cutis Laxa	38.4%
8	Xeroderma	36.7%
9	Sjogren-Larsson Syndrome	36.6%
10	Acrodermatitis	36.1%
11	Porokeratosis	36.1%
12	Gianotti-Crosti Syndrome	36.1%
13	Keratoderma, Palmoplantar	36.1%
14	Hyperkeratosis, Epidermolytic	33.8%
15	Albinism	30.7%
16	Panniculitis, Lupus Erythematosus	30.2%
17	Lupus Erythematosus, Cutaneous	30.2%
18	Panniculitis	30.2%
19	Systemic Scleroderma	30.2%
20	Morphea	30.2%
21	Pyoderma Gangrenosum	30.1%
22	Papillon-Lefevre Disease	27.2%
23	Erythema Induratum	24.8%
24	Necrobiosis Lipoidica Diabeticorum	24.5%
25	Dermatomyositis	24.4%
26	Behcet Syndrome	23.9%
27	Porphyrias, Hepatic	23.9%
28	Shwartzman Phenomenon	23.3%
29	Marfan Syndrome	23.1%
30	Dermatitis, Phototoxic	22.8%
31	Pityriasis Lichenoides et Varioliformis Acuta	22.8%
32	Pityriasis Lichenoides	22.8%
33	Phototoxicity	22.8%
34	Acne Vulgaris	22.3%
35	Contact Dermatitis	22.3%
36	Eczema	22.3%
37	Erythema Multiforme	22.3%
38	Intertrigo	22.3%
39	Neurodermatitis	22.3%
40	Rhinophyma	22.3%
41	Perioral Dermatitis	22.3%
42	Acne	22.3%
43	Nail-Patella Syndrome	21.5%
44	Lupus Erythematosus, Discoid	20.8%
45	Scleroderma, Limited	20.8%
46	Dermatitis, Photoallergic	20.7%
47	Dermatitis Herpetiformis	20.2%
48	Sebaceous Gland Neoplasms	20.1%
49	Foot Ulcer	19.6%
50	Cryoglobulinemia	19.3%
51	Hemangioma, Cavernous	19.3%
52	Scurvy	19.2%
53	Breast Diseases	18.6%
54	Dermatitis	18.6%
55	Exanthema	18.6%
56	Facial Dermatoses	18.6%
57	Hair Diseases	18.6%
58	Hand Dermatoses	18.6%
59	keratoacanthoma	18.6%
60	Keratosis	18.6%
61	Nail Diseases	18.6%
62	Photosensitivity Disorders	18.6%
63	Prurigo	18.6%
64	Pyoderma	18.6%
65	Rosacea	18.6%
66	Sebaceous Gland Diseases	18.6%
67	Skin Diseases, Vesiculobullous	18.6%
68	Skin Ulcer	18.6%
69	Sweat Gland Diseases	18.6%
70	Skin Diseases, Papulosquamous	18.6%
71	Skin Diseases, Vascular	18.6%
72	Acneiform Eruptions	18.6%
73	Ocular Rosacea	18.6%
74	Subcorneal pustular dermatosis	18.6%
75	Erythematotelangiectatic Rosacea	18.6%
76	Papulopustular Rosacea	18.6%
77	Chronic Actinic Dermatitis	18.6%
78	Malignant Atrophic Papulosis	18.1%
79	Variegate Porphyria	17.8%
80	Acute intermittent porphyria	17.8%
81	Porphyria Cutanea Tarda	17.8%
82	Purpura, Hyperglobulinemic	17.6%
83	Aicardi's syndrome	17.6%
84	Urticaria Pigmentosa	17.6%
85	Toxic Epidermal Necrolysis	17.5%
86	Stevens-Johnson Syndrome	17.5%
87	Noonan Syndrome	17.5%
88	Waldenstrom Macroglobulinemia	17.1%
89	Holoprosencephaly	17.1%
90	Granuloma Annulare	17%
91	Dermatitis, Irritant	17%
92	Acne Conglobata	17%
93	Foot Diseases	16.9%
94	Angioedemas, Hereditary	16.8%
95	Osteogenesis Imperfecta	16.8%
96	Skin Diseases, Infectious	16.6%
97	Skin Neoplasms	16.6%
98	Pigmentation Disorders	16.6%
99	Lipomatosis	16.5%
100	Pruritus	16.5%
101	Erythema	16.5%
102	Necrolytic Migratory Erythema	16.5%
103	Cutaneous Fistula	16.5%
104	Nephrogenic Fibrosing Dermopathy	16.5%
105	Nephrogenic Systemic Fibrosis	16.5%
106	CREST Syndrome	16.5%
107	Multiple Myeloma	16.4%
108	Wiskott-Aldrich Syndrome	16.2%
109	Erythema Infectiosum	16.2%
110	Exanthema Subitum	16.1%
111	Beckwith-Wiedemann Syndrome	16.1%
112	Wolf-Hirschhorn Syndrome	16.1%
113	Erythema Nodosum	16%
114	Polyarteritis Nodosa	15.9%
115	Takayasu Arteritis	15.9%
116	Kartagener Syndrome	15.8%
117	Mucocutaneous Lymph Node Syndrome	15.8%
118	Thrombasthenia	15.8%
119	Dermatitis, Occupational	15.6%
120	Dermatitis, Allergic Contact	15.3%
121	Collagen Diseases	15.2%
122	Mixed Connective Tissue Disease	15.2%
123	Mucinoses	15.2%
124	Menkes Kinky Hair Syndrome	15%
125	Tinea Capitis	14.9%
126	Onychomycosis	14.9%
127	Afibrinogenemia	14.8%
128	Factor VII Deficiency	14.8%
129	Factor X Deficiency	14.8%
130	Factor XII Deficiency	14.8%
131	Hemophilia A	14.8%
132	Factor II deficiency	14.8%
133	Factor VIII Deficiency	14.8%
134	Factor V deficiency	14.8%
135	Factor XI Deficiency	14.8%
136	Hypoprothrombinemias	14.8%
137	Mastocytosis	14.8%
138	Smith-Magenis syndrome	14.7%
139	Ecthyma	14.6%
140	Cri-du-Chat Syndrome	14.5%
141	Down Syndrome	14.5%
142	Trisomy 21	14.5%
143	Diaper Rash	14.3%
144	Rubinstein-Taybi Syndrome	14.2%
145	Mucopolysaccharidosis II	14.1%
146	Livedo Reticularis	14%
147	Cartilage Diseases	13.8%
148	Rheumatism	13.8%
149	Chondromalacia	13.8%
150	Anemia, Sickle Cell	13.8%
151	Thalassemia	13.8%
152	Angioedema	13.7%
153	Homocystinuria	13.7%
154	Lupus Erythematosus, Systemic	13.6%
155	Overlap syndrome	13.6%
156	CHARGE Syndrome	13.5%
157	Giant Cell Arteritis	13.4%
158	Temporal Arteritis	13.4%
159	Pseudoxanthoma Elasticum	13.4%
160	Prader-Willi Syndrome	13.3%
161	Alstrom Syndrome	13.2%
162	Fragile X Syndrome	13.2%
163	Disseminated Intravascular Coagulation	13%
164	Cardiovascular Abnormalities	13%
165	Scimitar Syndrome	13%
166	Varicose Ulcer	13%
167	Hidradenitis Suppurativa	12.7%
168	Anhidrosis	12.6%
169	Cholesteatoma	12.6%
170	Pressure Ulcer	12.6%
171	Folliculitis	12.6%
172	Foot Dermatoses	12.6%
173	Gynecomastia	12.6%
174	Hypertrichosis	12.6%
175	Hypohidrosis	12.6%
176	Hypotrichosis	12.6%
177	Leg Ulcer	12.6%
178	Miliaria	12.6%
179	Parakeratosis	12.6%
180	Parapsoriasis	12.6%
181	Pityriasis	12.6%
182	Psoriasis	12.6%
183	Sweet Syndrome	12.6%
184	Hidradenitis	12.6%
185	Onycholysis	12.6%
186	Miliaria Rubra	12.6%
187	Hyperpigmentation	12.6%
188	Lichenoid Eruptions	12.6%
189	Chloracne	12.6%
190	Erythema Chronicum Migrans	12.5%
191	Pelger-Huet Anomaly	12.4%
192	Cockayne Syndrome	12.3%
193	Thrombocythemia, Essential	12.2%
194	Antithrombin III Deficiency	12.1%
195	Protein C Deficiency	12.1%
196	Skin Abnormalities	12.1%
197	Dupuytren Contracture	12.1%
198	Laryngomalacia	11.9%
199	Pectus carinatum	11.8%
200	Tinea Pedis	11.6%
201	Acantholysis	11.2%
202	Breast Cyst	11.2%
203	Actinic keratosis	11.2%
204	Pemphigoid, Benign Mucous Membrane	11.2%
205	Pemphigus	11.2%
206	Piedra	11.2%
207	Sunburn	11.2%
208	Cystic Fibrosis	11.2%
209	Mucopolysaccharidosis III	11.2%
210	Activated Protein C Resistance	11.2%
211	Argyria	11.2%
212	Hirsutism	11.2%
213	Lactation Disorder	11.2%
214	Mastitis	11.2%
215	Urticaria	11.2%
216	Adiposis Dolorosa	11.1%
217	Pruritus Vulvae	11.1%
218	Mastocytoma	11.1%
219	Pruritus Ani	11.1%
220	Cellulitis	11%
221	Lymphatic Abnormalities	10.9%
222	Dextrocardia	10.9%
223	Scleromyxedema	10.9%
224	Mycetoma	10.8%
225	Williams Syndrome	10.4%
226	Peutz-Jeghers Syndrome	10.2%
227	Arteriovenous fistula	10.2%
228	Smith-Lemli-Opitz Syndrome	10.2%
229	Abnormalities, Drug-Induced	10.1%
230	Situs Inversus	10.1%
231	Sickle Cell Trait	10.1%
232	Dermatomycoses	10.1%
233	Skin Diseases, Bacterial	10.1%
234	Drug Eruptions	10%
235	Lipodystrophy	10%
236	Vitamin K Deficiency	10%
237	Bronchomalacia	10%
238	Tracheomalacia	10%
239	Turner Syndrome	9.8%
240	Dural Arteriovenous Fistula	9.8%
241	Mesenteric Panniculitis	9.7%
242	Panniculitis, Peritoneal	9.7%
243	Tietze's Syndrome	9.7%
244	Orbital Cellulitis	9.7%
245	Myxoid cyst	9.7%
246	Myxedema	9.7%
247	Muscular Dystrophy, Duchenne	9.7%
248	Polycystic Kidney Diseases	9.7%
249	Lichen Planus	9.6%
250	Melanosis	9.6%
251	Chloasma	9.6%
252	Pityriasis Rosea	9.6%
253	Pityriasis Rubra Pilaris	9.6%
254	Vitiligo	9.6%
255	Lichen Nitidus	9.6%
256	Diabetic Foot	9.5%
257	Anencephaly	9.3%
258	May-Thurner Syndrome	9.3%
259	Anemia, Diamond-Blackfan	9.3%
260	Eye Abnormalities	9.2%
261	Neoplastic Syndromes, Hereditary	9.2%
262	Retinal Dysplasia	9.1%
263	Myocardial Ischemia	9.1%
264	Congenital Microtia	9.1%
265	Protein S Deficiency	9%
266	Aniridia	9%
267	Multiple Epiphyseal Dysplasia	9%
268	Osteochondrodysplasias	9%
269	Werner Syndrome	9%
270	Myasthenic Syndromes, Congenital	9%
271	Congenital diaphragmatic hernia	9%
272	Aortic Aneurysm	8.9%
273	Aortitis	8.9%
274	Leriche Syndrome	8.9%
275	Periphlebitis	8.9%
276	Phlebitis	8.9%
277	Thromboangiitis Obliterans	8.9%
278	Myocardial Reperfusion Injury	8.9%
279	Tuberous Sclerosis	8.9%
280	Fabry Disease	8.9%
281	Hereditary Angioedema Type III	8.8%
282	Hereditary Angioedema Types I and II	8.8%
283	Osteochondritis	8.8%
284	Polymyalgia Rheumatica	8.8%
285	Primary Ciliary Dyskinesia	8.8%
286	Refsum Disease	8.7%
287	Kallmann Syndrome	8.7%
288	Acute Chest Syndrome	8.7%
289	Ataxia Telangiectasia	8.6%
290	Keloid	8.6%
291	Retinal Vein Occlusion	8.6%
292	Connective Tissue Diseases	8.6%
293	Alopecia	8.6%
294	Sweating, Gustatory	8.6%
295	Androgenetic Alopecia	8.6%
296	Auriculotemporal Syndrome	8.6%
297	Mobius Syndrome	8.6%
298	Maxillofacial Abnormalities	8.5%
299	Lice Infestations	8.5%
300	Breast Neoplasms, Male	8.5%
301	Triple Negative Breast Neoplasms	8.5%
302	Galactorrhea	8.5%
303	Classical Lissencephalies and Subcortical Band Heterotopias	8.5%
304	Thrombophlebitis	8.4%
305	Autoimmune Lymphoproliferative Syndrome	8.3%
306	Urogenital Abnormalities	8.3%
307	Rheumatoid Vasculitis	8.3%
308	Dwarfism	8.2%
309	Adrenoleukodystrophy	8.2%
310	Aortic Rupture	8.2%
311	Acanthosis Nigricans	8.1%
312	Alopecia Areata	8.1%
313	Lentigo	8.1%
314	Muscular Dystrophy	8.1%
315	Lupus Vasculitis, Central Nervous System	8%
316	Rheumatoid Arthritis	8%
317	Juvenile arthritis	8%
318	Coronary Aneurysm	8%
319	Rett Syndrome	7.9%
320	Anemia, Neonatal	7.9%
321	Splenic Infarction	7.9%
322	Lupus Nephritis	7.8%
323	Moyamoya Disease	7.8%
324	Postphlebitic Syndrome	7.8%
325	Zellweger Syndrome	7.8%
326	Larva Migrans	7.7%
327	Leishmaniasis	7.7%
328	Molluscum Contagiosum	7.7%
329	Onchocerciasis	7.7%
330	Fetal Diseases	7.7%
331	Acrocephalosyndactylia	7.7%
332	Chromoblastomycosis	7.6%
333	Dermatophytosis	7.6%
334	Sporotrichosis	7.6%
335	Tinea	7.6%
336	Tinea Versicolor	7.6%
337	Trichophytosis	7.6%
338	Hyalohyphomycosis	7.6%
339	Carotid Artery Thrombosis	7.6%
340	Acute Generalized Exanthematous Pustulosis	7.6%
341	Aneurysm	7.6%
342	Angiomatosis	7.6%
343	Aortic Diseases	7.6%
344	Arterial Occlusive Diseases	7.6%
345	Hyperemia	7.6%
346	Hypotension	7.6%
347	Superior Vena Cava Syndrome	7.6%
348	Telangiectasis	7.6%
349	Vasculitis	7.6%
350	Venous Insufficiency	7.6%
351	Peripheral Vascular Diseases	7.6%
352	Embolism and Thrombosis	7.6%
353	Angiodysplasia	7.6%
354	Capillary Leak Syndrome	7.6%
355	Prehypertension	7.6%
356	Myotonic Dystrophy	7.6%
357	Fanconi Anemia	7.5%
358	Hydrops Fetalis	7.5%
359	Lymphangiectasis, Intestinal	7.4%
360	Hepatolenticular Degeneration	7.3%
361	Chronic granulomatous disease	7.3%
362	Tricuspid Atresia	7.3%
363	Arrhythmogenic Right Ventricular Dysplasia	7.3%
364	Lichen Planus, Oral	7.3%
365	Polycystic Kidney, Autosomal Dominant	7.2%
366	Neuronal Ceroid-Lipofuscinoses	7.2%
367	Warts	7.1%
368	Klinefelter Syndrome	7%
369	Intracranial Embolism and Thrombosis	7%
370	Rheumatoid Nodule	7%
371	Carotid Stenosis	7%
372	Intracranial Aneurysm	7%
373	Coronary Thrombosis	7%
374	Coronary Artery Disease	7%
375	Candidiasis, Chronic Mucocutaneous	6.9%
376	Cutaneous Candidiasis	6.9%
377	Autoimmune thrombocytopenia	6.9%
378	Immune thrombocytopenic purpura	6.9%
379	Erysipelas	6.9%
380	Serum Sickness	6.9%
381	Staphylococcal Skin Infections	6.9%
382	Blue Toe Syndrome	6.9%
383	Erythrasma	6.9%
384	Carcinoma, Lobular	6.9%
385	Arthritis, Psoriatic	6.9%
386	Vascular System Injuries	6.9%
387	Meconium Aspiration Syndrome	6.8%
388	Compartment syndromes	6.8%
389	Hepatic Veno-Occlusive Disease	6.8%
390	Peliosis Hepatis	6.8%
391	Varicocele	6.8%
392	Cerebrovascular Disorders	6.7%
393	Diabetic Angiopathies	6.7%
394	Reperfusion Injury	6.7%
395	Cerebrovascular Insufficiency	6.7%
396	Vascular Neoplasms	6.7%
397	Spinal Cord Vascular Diseases	6.7%
398	Vasoplegia	6.7%
399	Hemorrhoids	6.7%
400	Thoracic Outlet Syndrome	6.7%
401	Vasculitis, Central Nervous System	6.7%
402	Familial Mediterranean Fever	6.7%
403	Prune Belly Syndrome	6.7%
404	Twins, Conjoined	6.7%
405	Waardenburg Syndrome	6.7%
406	Abnormalities, Radiation-Induced	6.7%
407	Aortic coarctation	6.7%
408	Cor Triatriatum	6.7%
409	Coronary Vessel Anomalies	6.7%
410	Patent ductus arteriosus	6.7%
411	Ebstein Anomaly	6.7%
412	Heart Septal Defects	6.7%
413	Tetralogy of Fallot	6.7%
414	Transposition of Great Vessels	6.7%
415	Hypoplastic Left Heart Syndrome	6.7%
416	POEMS Syndrome	6.6%
417	Aortic Aneurysm, Abdominal	6.6%
418	Aortic Aneurysm, Thoracic	6.6%
419	Craniosynostosis	6.6%
420	Syndactyly	6.6%
421	Brachycephaly	6.6%
422	Basal Cell Nevus Syndrome	6.6%
423	Microcephaly	6.6%
424	Macrocephaly	6.6%
425	Charcot-Marie-Tooth Disease	6.6%
426	Antley-Bixler Syndrome Phenotype	6.6%
427	Amyloid Neuropathies, Familial	6.6%
428	Glycogen storage disease type II	6.5%
429	Leishmaniasis, Cutaneous	6.5%
430	Eczema Herpeticum	6.5%
431	Fusariosis	6.4%
432	Cleft Palate	6.4%
433	Felty Syndrome	6.3%
434	Anemia	6.3%
435	Blood Coagulation Disorders	6.3%
436	Blood Platelet Disorders	6.3%
437	Bone Marrow Diseases	6.3%
438	Leukocyte Disorders	6.3%
439	Methemoglobinemia	6.3%
440	Pancytopenia	6.3%
441	Polycythemia	6.3%
442	Sulfhemoglobinemia	6.3%
443	Thrombophilia	6.3%
444	Erythrocytosis	6.3%
445	Hand-Arm Vibration Syndrome	6.2%
446	Optic Neuropathy, Ischemic	6.1%
447	Anterior Ischemic Optic Neuropathy	6.1%
448	Mesenteric vascular insufficiency	6.1%
449	Galactosemias	6.1%
450	Urea Cycle Disorders, Inborn	6.1%
451	Tyrosinemias	6.1%
452	Long QT Syndrome	6.1%
453	Leukomalacia, Periventricular	6%
454	Bone Marrow Neoplasms	6%
455	Colitis, Ischemic	6%
456	Anophthalmos	6%
457	Anus, Imperforate	6%
458	Hydranencephaly	6%
459	Microphthalmos	6%
460	Neural Tube Defects	6%
461	Tethered Cord Syndrome	6%
462	Iniencephaly	6%
463	Craniorachischisis	6%
464	Limb Deformities, Congenital	6%
465	Exencephaly	6%
466	Septo-Optic Dysplasia	6%
467	Craniofacial Abnormalities	6%
468	Cortical Dysplasia	6%
469	Malformations of Cortical Development	6%
470	Anorectal Malformations	6%
471	Porencephaly	6%
472	Wolff-Parkinson-White Syndrome	6%
473	Intracranial Arteriosclerosis	6%
474	Cerebral Atherosclerosis	6%
475	Cerebral Arteriosclerosis	6%
476	Amino Acid Metabolism, Inborn Errors	5.9%
477	Bloom Syndrome	5.9%
478	Carbohydrate Metabolism, Inborn Errors	5.9%
479	Coronary heart disease	5.9%
480	Metal Metabolism, Inborn Errors	5.9%
481	Myocardial Infarction	5.9%
482	Progeria	5.9%
483	Lysosomal Storage Diseases	5.9%
484	Cytochrome-c Oxidase Deficiency	5.9%
485	Peroxisomal Disorders	5.9%
486	Acute Coronary Syndrome	5.9%
487	Ectopia Cordis	5.9%
488	Single umbilical artery	5.9%
489	Blastomycosis	5.9%
490	Epidermodysplasia Verruciformis	5.9%
491	Herpes Labialis	5.9%
492	HIV-Associated Lipodystrophy Syndrome	5.8%
493	Staphylococcal Scalded Skin Syndrome	5.8%
494	Transfusion Reaction	5.7%
495	Hypotensive Transfusion Reaction	5.7%
496	Canavan Disease	5.7%
497	Alexander Disease	5.7%
498	Jaw Abnormalities	5.7%
499	Pregnancy Complications, Hematologic	5.7%
500	Hematologic Neoplasms	5.7%
501	Optic Atrophy, Hereditary, Leber	5.7%
502	Hyperphosphaturia	5.6%
503	Subarachnoid Hemorrhage, Traumatic	5.6%
504	Carotid Artery, Internal, Dissection	5.6%
505	Lemierre Syndrome	5.6%
506	Thrombocytosis	5.6%
507	Waterhouse-Friderichsen Syndrome	5.5%
508	Rhinoscleroma	5.5%
509	Poland Syndrome	5.5%
510	Gaucher Disease	5.5%
511	Cerebral Thrombosis	5.4%
512	Intracranial Embolism	5.4%
513	Intracranial Thrombosis	5.4%
514	Blepharophimosis	5.4%
515	Laryngostenosis	5.4%
516	Mouth Abnormalities	5.4%
517	Polycythemia Vera	5.4%
518	Condylomata Acuminata	5.4%
519	Brain Infarction	5.4%
520	Esophageal Atresia	5.4%
521	Intestinal Atresia	5.4%
522	Horseshoe Kidney	5.4%
523	Pectus excavatum	5.4%
524	Kounis Syndrome	5.4%
525	Furunculosis	5.4%
526	furuncle	5.4%
527	Klippel-Feil Syndrome	5.4%
528	Retinitis Pigmentosa	5.4%
529	Gastroschisis	5.4%
530	Synostosis	5.4%
531	Pigmentary retinopathy	5.4%
532	Sicca Syndrome	5.4%
533	Sjogren's Syndrome	5.4%
534	Impetigo	5.3%
535	Angina Pectoris	5.3%
536	Welander Distal Myopathy	5.3%
537	Aortopulmonary Septal Defect	5.3%
538	Double Outlet Right Ventricle	5.3%
539	Endocardial Cushion Defects	5.3%
540	Myocardial bridging	5.3%
541	Aorticopulmonary Septal Defect	5.3%
542	carbuncle	5.3%
543	Infarction, Middle Cerebral Artery	5.3%
544	Infarction, Anterior Cerebral Artery	5.3%
545	Infarction, Posterior Cerebral Artery	5.3%
546	Leigh Disease	5.2%
547	Niemann-Pick Disease, Type C	5.1%
548	Abdominal Cramps	5.1%
549	Amniotic Band Syndrome	5.1%
550	Asphyxia Neonatorum	5.1%
551	Infant, Premature, Diseases	5.1%
552	Infantile Colic	5.1%
553	Embolism, Amniotic Fluid	5%
554	Aneurysm, Dissecting	5%
555	Arteriosclerosis	5%
556	Arteritis	5%
557	Embolism	5%
558	Erythromelalgia	5%
559	Fibromuscular Dysplasia	5%
560	Malignant Hypertension	5%
561	Raynaud Disease	5%
562	Thromboembolism	5%
563	Thrombosis	5%
564	Essential Hypertension	5%
565	Aneurysm, Ruptured	5%
566	Iliac Aneurysm	5%
567	Pulmonary artery stenosis	5%
568	White Coat Hypertension	5%
569	Systemic Vasculitis	5%
570	Embolus	5%
571	Tay-Sachs Disease	5%
572	Vertebral Artery Dissection	5%
573	Arthrogryposis	5%
574	Choanal Atresia	5%
575	Tracheobronchomegaly	5%
576	Laryngocele	5%
577	Choledochal Cyst	4.9%
578	Duane Retraction Syndrome	4.9%
579	Hermaphroditism	4.9%
580	Disorders of Sex Development	4.9%
581	Cryptorchidism	4.9%
582	Hypospadias	4.9%
583	Central Nervous System Cysts	4.9%
584	Dandy-Walker Syndrome	4.9%
585	Myotonia Congenita	4.8%
586	Brain Diseases, Metabolic, Inborn	4.8%
587	Dystonia Musculorum Deformans	4.8%
588	Micrognathism	4.8%
589	Pierre Robin Syndrome	4.8%
590	Lafora Disease	4.8%
591	Unverricht-Lundborg Syndrome	4.8%
592	Romano-Ward Syndrome	4.8%
593	Purpura, Thrombotic Thrombocytopenic	4.7%
594	Sinus Thrombosis, Intracranial	4.7%
595	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.7%
596	Truncus Arteriosus, Persistent	4.6%
597	Carotid Artery Injuries	4.6%
598	Multiple Endocrine Neoplasia	4.5%
599	Persistent Fetal Circulation Syndrome	4.5%
600	Retinal Artery Occlusion	4.5%
601	Retinal Vasculitis	4.5%
602	Hypertensive Retinopathy	4.5%
603	Retrognathia	4.5%
604	Cerebral Infarction	4.5%
605	Brain Stem Infarctions	4.5%
606	Bladder Exstrophy	4.5%
607	Congenital Hypothyroidism	4.5%
608	Epispadias	4.5%
609	Umbilical hernia	4.5%
610	Anterior Compartment Syndrome	4.5%
611	Vasculitis, Leukocytoclastic, Cutaneous	4.5%
612	Gastric Antral Vascular Ectasia	4.5%
613	Abdominal Compartment Syndrome	4.5%
614	Multicystic Dysplastic Kidney	4.5%
615	Amelia	4.4%
616	Arachnodactyly	4.4%
617	Carotid Artery Diseases	4.4%
618	Brain Ischemia	4.4%
619	Ectromelia	4.4%
620	Hemimelia	4.4%
621	Hypotension, Orthostatic	4.4%
622	Meningomyelocele	4.4%
623	Phocomelia	4.4%
624	Sirenomelia	4.4%
625	Cerebrovascular accident	4.4%
626	Spina Bifida	4.4%
627	Polydactyly	4.4%
628	Brachydactyly	4.4%
629	Plagiocephaly	4.4%
630	Lower Extremity Deformities, Congenital	4.4%
631	Upper Extremity Deformities, Congenital	4.4%
632	Vasospasm, Intracranial	4.4%
633	Spinal Cord Ischemia	4.4%
634	Intracranial Arterial Diseases	4.4%
635	Primary Graft Dysfunction	4.4%
636	Post-Exercise Hypotension	4.4%
637	Alkaptonuria	4.4%
638	Glycogen Storage Disease	4.4%
639	Hemoglobinuria, Paroxysmal	4.4%
640	Hypophosphatasia	4.4%
641	Leukemoid Reaction	4.4%
642	Coronary Occlusion	4.4%
643	Microvascular Angina	4.4%
644	Coronary Stenosis	4.4%
645	Propionic acidemia	4.4%
646	ST segment elevation myocardial infarction	4.4%
647	Dihydropyrimidine Dehydrogenase Deficiency	4.4%
648	Cystinosis	4.4%
649	Kernicterus	4.4%
650	Hyperandrogenism	4.4%
651	Cavernous Sinus Thrombosis	4.3%
652	Sagittal Sinus Thrombosis	4.3%
653	Heart Diseases	4.3%
654	Deformity	4.3%
655	Genetic Diseases, Inborn	4.3%
656	MELAS Syndrome	4.3%
657	Prognathism	4.2%
658	Basal Ganglia Hemorrhage	4.1%
659	Neonatal Abstinence Syndrome	4.1%
660	Agammaglobulinemia	4%
661	Fetal Growth Retardation	4%
662	Mesenteric Vascular Occlusion	4%
663	Diabetic Retinopathy	4%
664	Sturge-Weber Syndrome	4%
665	Fetal Hypoxia	4%
666	Congenital nystagmus	4%
667	Fetal Alcohol Spectrum Disorders	4%
668	Lateral Medullary Syndrome	4%
669	Toxoplasmosis, Congenital	4%
670	Dental Enamel Hypoplasia	4%
671	Renal hypertension	4%
672	Hypodontia	4%
673	Macrostomia	4%
674	Meningocele	4%
675	Microstomia	4%
676	Renal Artery Obstruction	4%
677	Renal Artery Stenosis	4%
678	Syphilis, Congenital	4%
679	Encephalocele	4%
680	Craniofacial Dysostosis	4%
681	Shock, Cardiogenic	4%
682	Basal Ganglia Cerebrovascular Disease	4%
683	Vascular Headaches	4%
684	Hypolipoproteinemias	4%
685	Hyperlipidemia, Familial Combined	4%
686	Angina, Unstable	4%
687	Hyperlipoproteinemia Type III	4%
688	Lymphatic Diseases	3.9%
689	Pregnancy Complications, Cardiovascular	3.8%
690	Huntington Disease	3.8%
691	Anemia, Hemolytic	3.8%
692	Anemia, Macrocytic	3.8%
693	Eosinophilia	3.8%
694	Hypoproteinemia	3.8%
695	Leukopenia	3.8%
696	Thrombocytopenia	3.8%
697	Leukostasis	3.8%
698	MYELODYSPLASTIC SYNDROME	3.8%
699	Denys-Drash Syndrome	3.8%
700	Arteriosclerosis Obliterans	3.7%
701	Atherosclerosis	3.7%
702	Air Embolism	3.7%
703	Endarteritis	3.7%
704	Venous Thrombosis	3.7%
705	Deep Vein Thrombosis	3.7%
706	Venous Thromboembolism	3.7%
707	Dermal Sinus	3.7%
708	Spina Bifida Cystica	3.7%
709	Spina Bifida Occulta	3.7%
710	Lissencephaly	3.7%
711	Polymicrogyria	3.7%
712	Pachygyria	3.7%
713	Schizencephaly	3.7%
714	Periventricular Nodular Heterotopia	3.7%
715	Glycogen Storage Disease Type I	3.7%
716	Glycogen Storage Disease Type V	3.7%
717	Coronary Restenosis	3.7%
718	Congenital Hyperinsulinism	3.7%
719	Chorioamnionitis	3.7%
720	Familial Periodic Paralysis	3.6%
721	Ischemic contracture	3.6%
722	Infectious Mononucleosis	3.6%
723	Platybasia	3.6%
724	Gonadal Dysgenesis	3.6%
725	Monoclonal Gammopathy of Undetermined Significance	3.6%
726	Adrenogenital Syndrome	3.6%
727	Ovotesticular Disorders of Sex Development	3.6%
728	Lactose Intolerance	3.6%
729	Hyperhomocysteinemia	3.6%
730	Renal Aminoacidurias	3.6%
731	Fanconi Syndrome	3.6%
732	Pseudohypoaldosteronism	3.6%
733	Liddle Syndrome	3.6%
734	Hyperlipoproteinemia Type IV	3.6%
735	Hyperlipoproteinemia Type V	3.6%
736	Putaminal Hemorrhage	3.6%
737	Nephroblastoma	3.5%
738	Dementia, Vascular	3.5%
739	Familial Hypophosphatemic Rickets	3.4%
740	Leukocytosis	3.4%
741	Paraproteinemias	3.4%
742	Pleocytosis	3.4%
743	Intermittent Claudication	3.4%
744	Pulmonary Embolism	3.4%
745	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.4%
746	Gout	3.3%
747	No-Reflow Phenomenon	3.3%
748	Multiple Endocrine Neoplasia Type 1	3.3%
749	Pseudohypoparathyroidism	3.3%
750	Cerebral Arterial Diseases	3.3%
751	Vertebrobasilar Insufficiency	3.3%
752	Anterior Spinal Artery Syndrome	3.3%
753	Basilar Artery Stenosis	3.3%
754	Vertebral Artery Stenosis	3.3%
755	Intracranial Hemorrhage, Hypertensive	3.3%
756	Transient Cerebral Ischemia	3.3%
757	Shy-Drager Syndrome	3.3%
758	Friedreich Ataxia	3.3%
759	Hypoalphalipoproteinemias	3.3%
760	Renal tubular acidosis	3.3%
761	Angina Pectoris, Variant	3.3%
762	Adenomatous Polyposis Coli	3.3%
763	Hemolytic-Uremic Syndrome	3.1%
764	Bacterial Endocarditis	3.1%
765	Ophthalmia Neonatorum	3.1%
766	Hypergammaglobulinemia	3.1%
767	Transfusion-Related Acute Lung Injury	3%
768	Ecchymosis	3%
769	Petechiae	3%
770	Purpura	3%
771	Hypokalemic periodic paralysis	3%
772	Mandibulofacial Dysostosis	3%
773	Heavy Chain Disease	3%
774	Paralysis, Obstetric	3%
775	Retinopathy of Prematurity	3%
776	Cystinuria	3%
777	Hypertension, Renovascular	3%
778	Subarachnoid Hemorrhage	3%
779	Hypoxia-Ischemia, Brain	3%
780	Cerebral Hemorrhage	3%
781	Aortic Valve Stenosis	3%
782	Cardiomyopathy, Dilated	3%
783	Pulmonary Valve Stenosis	3%
784	Bronchopulmonary Dysplasia	3%
785	Goldenhar Syndrome	3%
786	Thrombocytopenic purpura	2.9%
787	Glycosuria, Renal	2.8%
788	Hepatic Vein Thrombosis	2.8%
789	Budd-Chiari Syndrome	2.8%
790	Pulmonary Infarction	2.8%
791	Subclavian Steal Syndrome	2.8%
792	Arthritis, Gouty	2.7%
793	Pituitary Apoplexy	2.7%
794	Respiratory Distress Syndrome, Newborn	2.7%
795	Talipes	2.7%
796	Heart Block	2.7%
797	Tachycardia	2.7%
798	Tachyarrhythmia	2.7%
799	Congenital clubfoot	2.5%
800	Vertical Talus	2.5%
801	Cardiac Tamponade	2.5%
802	Endocarditis	2.5%
803	Cardiac Arrest	2.5%
804	Heart failure	2.5%
805	Pericardial effusion	2.5%
806	Pericarditis	2.5%
807	Pneumopericardium	2.5%
808	Cor pulmonale	2.5%
809	Ventricular Outflow Obstruction	2.5%
810	Ventricular Dysfunction	2.5%
811	Cardiomyopathies	2.5%
812	Pleuropericarditis	2.5%
813	Primary Myelofibrosis	2.5%
814	Agranulocytosis	2.5%
815	Anemia, Megaloblastic	2.5%
816	Lymphocytosis	2.5%
817	Myelofibrosis	2.5%
818	Myeloid Metaplasia	2.5%
819	Hypoalbuminemia	2.5%
820	Hypereosinophilic syndrome	2.5%
821	bone marrow fibrosis	2.5%
822	Thrombotic Microangiopathies	2.5%
823	Granulomatosis with polyangiitis	2.5%
824	Cerebral Amyloid Angiopathy	2.5%
825	Sick Sinus Syndrome	2.5%
826	Atypical Hemolytic Uremic Syndrome	2.5%
827	Nesidioblastosis	2.4%
828	Hypertrophic Cardiomyopathy	2.4%
829	Hypertrophic obstructive cardiomyopathy	2.4%
830	Cardiac Output, High	2.3%
831	Myocardial Stunning	2.3%
832	Low Cardiac Output Syndrome	2.3%
833	Cardiomegaly	2.2%
834	Postpericardiotomy Syndrome	2.2%
835	Cardiac Hypertrophy	2.2%
836	Lymphopenia	2.2%
837	Rheumatic Heart Disease	2.2%
838	Eosinophilic Granuloma	2.2%
839	Job Syndrome	2.2%
840	Supravalvular aortic stenosis	2.2%
841	Leukemia, Myelomonocytic, Chronic	2.2%
842	Lown-Ganong-Levine Syndrome	2.2%
843	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	2.2%
844	Adenitis	2.1%
845	Histiocytosis	2.1%
846	Lymphadenitis	2.1%
847	Lymphangitis	2.1%
848	Lymphedema	2.1%
849	Splenic Diseases	2.1%
850	Thymus Hyperplasia	2.1%
851	Pseudolymphoma	2.1%
852	Lymphadenopathy	2.1%
853	Eosinophilia-Myalgia Syndrome	2%
854	Hyaline Membrane Disease	2%
855	Adams-Stokes Syndrome	2%
856	Atrioventricular Block	2%
857	Bundle-Branch Block	2%
858	Atrial Premature Complexes	2%
859	Sinoatrial Block	2%
860	Tachycardia, Paroxysmal	2%
861	Supraventricular tachycardia	2%
862	Tachycardia, Ventricular	2%
863	Purpura Fulminans	2%
864	Tachycardia, Reciprocating	2%
865	Subacute Bacterial Endocarditis	1.9%
866	Hematoma, Subdural	1.9%
867	Hematoma, Epidural, Cranial	1.9%
868	Lymphocele	1.9%
869	Lymphoproliferative Disorders	1.9%
870	Thymus Neoplasms	1.9%
871	Neutropenia	1.9%
872	Carcinoid Heart Disease	1.8%
873	Brain Hemorrhage, Traumatic	1.8%
874	Hematoma, Subdural, Intracranial	1.7%
875	Hematoma, Subdural, Chronic	1.7%
876	Hematoma, Subdural, Acute	1.7%
877	Pulmonary Eosinophilia	1.7%
878	Eosinophilic Pneumonia	1.7%
879	Aortic Valve Insufficiency	1.7%
880	Restrictive cardiomyopathy	1.7%
881	Endocardial Fibroelastosis	1.7%
882	Heart Rupture, Post-Infarction	1.7%
883	Mitral Valve Insufficiency	1.7%
884	Mitral Valve Stenosis	1.7%
885	Myocarditis	1.7%
886	Pericarditis, Constrictive	1.7%
887	Pulmonary Valve Insufficiency	1.7%
888	Tricuspid Valve Insufficiency	1.7%
889	Tricuspid Valve Stenosis	1.7%
890	Ventricular Dysfunction, Left	1.7%
891	Right Ventricular Dysfunction	1.7%
892	Endomyocardial Fibrosis	1.7%
893	Carditis	1.7%
894	Heart Failure, Systolic	1.7%
895	Heart Failure, Diastolic	1.7%
896	Leukemia, Myeloid, Chronic-Phase	1.7%
897	Anemia, Pernicious	1.7%
898	Tachycardia, Atrioventricular Nodal Reentry	1.6%
899	Tachycardia, Ectopic Atrial	1.6%
900	Tachycardia, Ectopic Junctional	1.6%
901	Sinus Tachycardia	1.6%
902	Torsades de Pointes	1.6%
903	Accelerated Idioventricular Rhythm	1.6%
904	Febrile Neutropenia	1.6%
905	Sinus Arrhythmia	1.5%
906	Atrial Fibrillation	1.5%
907	Atrial Flutter	1.5%
908	Edema, Cardiac	1.5%
909	Ventricular Fibrillation	1.5%
910	Ventricular Flutter	1.5%
911	Parasystole	1.5%
912	Paroxysmal atrial fibrillation	1.5%
913	Bradycardia	1.5%
914	Diabetic Cardiomyopathies	1.5%
915	Cardiomyopathy, Alcoholic	1.5%
916	Sudden Cardiac Death	1.5%
917	Left Ventricular Hypertrophy	1.5%
918	Right Ventricular Hypertrophy	1.5%
919	Chagas Cardiomyopathy	1.5%
920	Dyspnea, Paroxysmal	1.3%
921	Elephantiasis	1.3%
922	Hypersplenism	1.3%
923	Sarcoidosis	1.3%
924	Elephantiasis Nostras Verrucosa	1.3%
925	Aortic Valve Prolapse	1.3%
926	Tricuspid Valve Prolapse	1.3%
927	Takotsubo Cardiomyopathy	1.3%
928	Sezary Syndrome	1.1%
929	Granuloma	1.1%
930	Histiocytic Disorders, Malignant	1.1%
931	Splenic Neoplasms	1.1%
932	Histiocytosis, Langerhans-Cell	1.1%
933	Tumor Lysis Syndrome	1.1%
934	Sinus Arrest, Cardiac	1.1%
935	Splenic Rupture	1%
936	Lymphoma	1%
937	Thymoma	1%
938	Lymphohistiocytosis, Hemophagocytic	0.8%
939	Erdheim-Chester Disease	0.8%
940	Kearns-Sayre syndrome	0.8%
941	Malignant histiocytosis	0.7%
942	Sarcoidosis, Pulmonary	0.7%
943	Histiocytic sarcoma	0.7%
944	Splenosis	0.7%
945	Hodgkin Disease	0.7%
946	Lymphoma, Non-Hodgkin	0.7%
947	Leukemia, T-Cell	0.7%
948	Leukemia, B-Cell	0.7%
949	Composite Lymphoma	0.6%
950	Lymphangioleiomyomatosis	0.6%
951	Lymphoma, Follicular	0.5%
952	T-Cell Lymphoma	0.5%
953	Mantle cell lymphoma	0.5%
954	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
955	Leukemia, Large Granular Lymphocytic	0.5%
956	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	0.5%
957	Lymphoma, T-Cell, Cutaneous	0.4%
958	Lymphoma, AIDS-Related	0.4%
959	Enteropathy-Associated T-Cell Lymphoma	0.4%
960	Primary Effusion Lymphoma	0.4%
961	Lymphomatoid Granulomatosis	0.4%
962	Mycosis Fungoides	0.4%
963	Lymphomatoid Papulosis	0.4%
964	Plasmablastic lymphoma	0.4%
965	Burkitt Lymphoma	0.3%

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