MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Klippel-Feil Syndrome

(UMLS:C0022738)

Definition:: A syndrome characterised by a low hairline and a shortened neck resulting from a reduced number of vertebrae or the fusion of multiple hemivertebrae into one osseous mass.
UMLS ID:: C0022738
MeSH ID:: D007714

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.370.535|C05.660.551

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.551

Synonym(s)

Klippel-Feil Syndrome

BREVICOLLIS

Bonnevie-Ullrich and Klippel-Feil syndrome

Cervical C2/C3 vertebral fusion

Cervical fusion syndrome

Cervical vertebral fusion

Cervical vertebral fusion syndrome

Cervical-vertebral fusion

Congenital dystrophia brevicollis

10.

Feil-Klippel

11.

Fusion of cervical vertebrae c2-3

12.

KFS - Klippel-Feil syndrome

13.

Klippel Feil Syndrome

14.

Klippel-Feil

15.

Klippel-Feil Sequence

16.

Klippel-Feil deformity

17.

Klippel-Feil sequence

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Paroxetine	FAERS: 2	US FAERS
2	Carbamazepine	FAERS: 1	US FAERS
3	Citalopram	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Synostosis	51.7%
2	Pectus excavatum	47.5%
3	Craniosynostosis	45.8%
4	Syndactyly	45.8%
5	Brachycephaly	45.8%
6	Acrocephalosyndactylia	45.7%
7	Craniofacial Dysostosis	42.5%
8	Pectus carinatum	41.3%
9	Arthrogryposis	40.9%
10	Platybasia	40%
11	Limb Deformities, Congenital	38.8%
12	Craniofacial Abnormalities	38.8%
13	Poland Syndrome	37.4%
14	Rubinstein-Taybi Syndrome	34.8%
15	Gastroschisis	32%
16	Antley-Bixler Syndrome Phenotype	29.6%
17	Goldenhar Syndrome	29.2%
18	Mandibulofacial Dysostosis	28.9%
19	Amelia	28%
20	Arachnodactyly	28%
21	Ectromelia	28%
22	Hemimelia	28%
23	Phocomelia	28%
24	Sirenomelia	28%
25	Polydactyly	28%
26	Brachydactyly	28%
27	Plagiocephaly	28%
28	Lower Extremity Deformities, Congenital	28%
29	Upper Extremity Deformities, Congenital	28%
30	Holoprosencephaly	26.2%
31	Maxillofacial Abnormalities	26%
32	Osteoarthropathy, Secondary Hypertrophic	24.8%
33	Gigantism	23.5%
34	Microcephaly	23.3%
35	Macrocephaly	23.3%
36	Talipes	23%
37	Multiple Epiphyseal Dysplasia	22.4%
38	Osteochondrodysplasias	22.4%
39	Jaw Abnormalities	21%
40	Osteochondritis	20.6%
41	Congenital clubfoot	20%
42	Vertical Talus	20%
43	Hyperostosis	19.7%
44	Osteitis	19.7%
45	Osteitis Deformans	19.7%
46	Osteochondrosis	19.7%
47	Spinal Diseases	19.7%
48	Porencephaly	19.6%
49	Dwarfism	19.3%
50	Noonan Syndrome	19%
51	Fasciitis	18.6%
52	Foot Deformities	18.6%
53	Arthropathy	18.6%
54	Marfan Syndrome	18.2%
55	Contracture	17.9%
56	Fasciitis, Plantar	17.9%
57	Laryngomalacia	17.6%
58	Micrognathism	17.2%
59	Pierre Robin Syndrome	17.2%
60	Prognathism	16.8%
61	Spinal Neoplasms	16.8%
62	Spondylitis	16.8%
63	Bone Diseases, Endocrine	16.3%
64	Congenital Hypothyroidism	16%
65	Bone Diseases, Infectious	15.9%
66	Bone neoplasms	15.9%
67	Osteopenia	15.9%
68	Chondrodysplasia Punctata	15.8%
69	Enchondromatosis	15.8%
70	Osteosclerosis	15.8%
71	Kashin-Beck Disease	15.8%
72	Bone Resorption	15.6%
73	Aseptic Necrosis of Bone	15.6%
74	Beckwith-Wiedemann Syndrome	15.6%
75	Wolf-Hirschhorn Syndrome	15.6%
76	Retrognathia	15.5%
77	Abnormalities, Drug-Induced	15.4%
78	Situs Inversus	15.4%
79	Cleft Palate	15.4%
80	Jaw Diseases	15.3%
81	Nail-Patella Syndrome	15.1%
82	Osteoarthritis, Spine	15.1%
83	Cartilage Diseases	14.9%
84	Foot Diseases	14.9%
85	Myopathy	14.9%
86	Rheumatism	14.9%
87	Chondromalacia	14.9%
88	Fibromyalgia	14.9%
89	Polymyalgia Rheumatica	14.9%
90	Metatarsalgia	14.8%
91	Cockayne Syndrome	14.4%
92	Gout	14.2%
93	Bronchomalacia	14.2%
94	Tracheomalacia	14.2%
95	Osteogenesis Imperfecta	14%
96	Basal Cell Nevus Syndrome	13.8%
97	Smith-Magenis syndrome	13.5%
98	Cri-du-Chat Syndrome	13.3%
99	Down Syndrome	13.3%
100	Trisomy 21	13.3%
101	Aicardi's syndrome	13.2%
102	Ischemic contracture	12.9%
103	Eye Abnormalities	12.8%
104	Cardiovascular Abnormalities	12.8%
105	Ankylosing spondylitis	12.6%
106	Ainhum	12.6%
107	Spinal Stenosis	12.6%
108	Spondylosis	12.6%
109	Intervertebral Disc Degeneration	12.6%
110	Melorheostosis	12.4%
111	Osteopetrosis	12.4%
112	Temporomandibular Joint Disorders	12.4%
113	Skin Abnormalities	12.4%
114	Lymphatic Abnormalities	12.4%
115	Congenital Microtia	12.4%
116	Rheumatic Fever	12.4%
117	Congenital diaphragmatic hernia	12.2%
118	Discitis	12.1%
119	Hip Contracture	12.1%
120	Periarthritis	12.1%
121	Ectodermal Dysplasia	11.7%
122	Aplasia Cutis Congenita	11.7%
123	Anencephaly	11.7%
124	Prader-Willi Syndrome	11.6%
125	Temporomandibular Joint Dysfunction Syndrome	11.4%
126	Arthritis	11.1%
127	Bursitis	11.1%
128	Joint Instability	11.1%
129	Myofascial Pain Syndromes	11.1%
130	Rhabdomyolysis	11.1%
131	Synovitis	11.1%
132	Joint laxity	11.1%
133	Polyarthritis	11.1%
134	Frozen shoulder	11.1%
135	Patellofemoral Pain Syndrome	11.1%
136	Arthritis, Psoriatic	10.8%
137	Rheumatoid Arthritis	10.7%
138	Juvenile arthritis	10.7%
139	Osteoarthritis, Knee	10.7%
140	Urogenital Abnormalities	10.7%
141	Bone Diseases	10.6%
142	Spondylarthropathies	10.6%
143	Arthritis, Gouty	10.5%
144	Tuberculosis, Spinal	10.3%
145	CHARGE Syndrome	10.2%
146	Dural Arteriovenous Fistula	10.1%
147	Prune Belly Syndrome	10.1%
148	Twins, Conjoined	10.1%
149	Waardenburg Syndrome	10.1%
150	Osteomyelitis	10.1%
151	Osteoporosis	10.1%
152	Periostitis	10.1%
153	Bone Demineralization, Pathologic	10.1%
154	Post-Traumatic Osteoporosis	10.1%
155	Kartagener Syndrome	10%
156	Alveolar Bone Loss	10%
157	Dextrocardia	10%
158	Femur Head Necrosis	10%
159	Osteolysis	10%
160	Arthritis, Reactive	9.8%
161	Eosinophilic Granuloma	9.6%
162	Lordosis	9.2%
163	Spondylolysis	9.2%
164	kyphosis	9.2%
165	Compartment syndromes	9%
166	Maxillary Diseases	9%
167	Tendinitis	9%
168	Tendinopathy	9%
169	Genetic Diseases, Inborn	8.8%
170	Hemarthrosis	8.8%
171	Myositis	8.8%
172	Tietze's Syndrome	8.8%
173	Isaacs syndrome	8.8%
174	Myotonic Disorders	8.8%
175	Rheumatoid Nodule	8.8%
176	Xeroderma	8.7%
177	Mobius Syndrome	8.7%
178	Muscular Dystrophy	8.4%
179	Acromegaly	8.3%
180	Joint Tuberculosis	8.3%
181	Tuberculosis, Osteoarticular	8.3%
182	Bone Tuberculosis	8.3%
183	Anophthalmos	8.2%
184	Anus, Imperforate	8.2%
185	Hydranencephaly	8.2%
186	Microphthalmos	8.2%
187	Neural Tube Defects	8.2%
188	Tethered Cord Syndrome	8.2%
189	Iniencephaly	8.2%
190	Craniorachischisis	8.2%
191	Exencephaly	8.2%
192	Septo-Optic Dysplasia	8.2%
193	Cortical Dysplasia	8.2%
194	Malformations of Cortical Development	8.2%
195	Anorectal Malformations	8.2%
196	Bloom Syndrome	8.1%
197	Scimitar Syndrome	8%
198	Myotonic Dystrophy	7.9%
199	Alstrom Syndrome	7.7%
200	Familial Periodic Paralysis	7.7%
201	Felty Syndrome	7.6%
202	Polycystic Kidney Diseases	7.6%
203	Williams Syndrome	7.6%
204	Bunion	7.6%
205	Fibrodysplasia Ossificans Progressiva	7.6%
206	Myoglobinuria	7.6%
207	Myositis Ossificans	7.6%
208	Tenosynovitis	7.6%
209	Sacroiliitis	7.6%
210	Abnormalities, Radiation-Induced	7.5%
211	Pseudohypoparathyroidism	7.5%
212	Spondylolisthesis	7.5%
213	Medial Tibial Stress Syndrome	7.4%
214	Fragile X Syndrome	7.4%
215	Mitochondrial Myopathies	7.3%
216	Muscle Cramp	7.3%
217	Eosinophilia-Myalgia Syndrome	7.3%
218	Osteoporosis, Postmenopausal	7.3%
219	Muscle Rigidity	7.2%
220	Muscle Spasticity	7.2%
221	Cogwheel Rigidity	7.2%
222	Nuchal Rigidity	7.2%
223	Rickets	7.1%
224	Muscular Dystrophy, Duchenne	7.1%
225	Fetal Diseases	7.1%
226	Classical Lissencephalies and Subcortical Band Heterotopias	7%
227	Turner Syndrome	6.9%
228	Retinal Dysplasia	6.9%
229	Blepharophimosis	6.9%
230	Laryngostenosis	6.9%
231	Mouth Abnormalities	6.9%
232	Bone Diseases, Developmental	6.8%
233	Aniridia	6.8%
234	Esophageal Atresia	6.8%
235	Intestinal Atresia	6.8%
236	Horseshoe Kidney	6.8%
237	Acrodermatitis	6.7%
238	Lymphangiectasis, Intestinal	6.7%
239	Gianotti-Crosti Syndrome	6.7%
240	Epidermolysis Bullosa	6.7%
241	Rheumatoid Vasculitis	6.6%
242	Palatal Neoplasms	6.6%
243	Ichthyosis, X-Linked	6.6%
244	Smith-Lemli-Opitz Syndrome	6.6%
245	Primary Ciliary Dyskinesia	6.6%
246	Chronic Fatigue Syndrome	6.5%
247	Giant Cell Epulis	6.3%
248	Muscle Weakness	6.3%
249	Musculoskeletal Pain	6.2%
250	Arthralgia	6.2%
251	Myotonia Congenita	6.2%
252	Polyarthralgia	6.2%
253	Arthritis, Infectious	6.1%
254	Welander Distal Myopathy	6.1%
255	Mastoiditis	6%
256	Petrositis	6%
257	Anterior Compartment Syndrome	6%
258	Enthesopathy	6%
259	Arthritis, Experimental	6%
260	Abdominal Compartment Syndrome	6%
261	Ectopia Cordis	6%
262	Meningomyelocele	6%
263	Spina Bifida	6%
264	Polymyositis	6%
265	Single umbilical artery	6%
266	Cystic Fibrosis	6%
267	Choanal Atresia	5.9%
268	Tracheobronchomegaly	5.9%
269	Laryngocele	5.9%
270	Sicca Syndrome	5.9%
271	Sjogren's Syndrome	5.9%
272	Choledochal Cyst	5.9%
273	Hermaphroditism	5.9%
274	Disorders of Sex Development	5.9%
275	Cryptorchidism	5.8%
276	Hypospadias	5.8%
277	Central Nervous System Cysts	5.8%
278	Dandy-Walker Syndrome	5.7%
279	Klinefelter Syndrome	5.7%
280	POEMS Syndrome	5.7%
281	Klippel-Feil Syndrome	5.6%
282	Polycystic Kidney, Autosomal Dominant	5.6%
283	Myalgia	5.4%
284	Hypokalemic periodic paralysis	5.4%
285	Pseudoxanthoma Elasticum	5.4%
286	Sjogren-Larsson Syndrome	5.3%
287	Meconium Aspiration Syndrome	5.2%
288	Osteomalacia	5.1%
289	Hip Dislocation	5.1%
290	Shoulder Dislocation	5.1%
291	Hip Dysplasia	5.1%
292	Abdominal Cramps	5.1%
293	Amniotic Band Syndrome	5.1%
294	Asphyxia Neonatorum	5.1%
295	Infant, Premature, Diseases	5.1%
296	Infantile Colic	5.1%
297	Orbital Myositis	5.1%
298	Bladder Exstrophy	5%
299	Dysostoses	5%
300	Epispadias	5%
301	Dupuytren Contracture	5%
302	Multicystic Dysplastic Kidney	5%
303	Aortic coarctation	5%
304	Cor Triatriatum	5%
305	Coronary Vessel Anomalies	5%
306	Dental Enamel Hypoplasia	5%
307	Patent ductus arteriosus	5%
308	Ebstein Anomaly	5%
309	Heart Septal Defects	5%
310	Hypodontia	5%
311	Macrostomia	5%
312	Meningocele	5%
313	Microstomia	5%
314	Tetralogy of Fallot	5%
315	Transposition of Great Vessels	5%
316	Hypoplastic Left Heart Syndrome	5%
317	Pyomyositis	5%
318	May-Thurner Syndrome	5%
319	Encephalocele	5%
320	Kallmann Syndrome	5%
321	Dermal Sinus	5%
322	Spina Bifida Cystica	5%
323	Spina Bifida Occulta	5%
324	Lissencephaly	5%
325	Polymicrogyria	5%
326	Pachygyria	5%
327	Schizencephaly	5%
328	Periventricular Nodular Heterotopia	5%
329	Wolff-Parkinson-White Syndrome	4.9%
330	Charcot-Marie-Tooth Disease	4.9%
331	Xeroderma Pigmentosum	4.9%
332	Hyperkeratosis, Epidermolytic	4.9%
333	Zellweger Syndrome	4.6%
334	Hyperandrogenism	4.4%
335	Tuberous Sclerosis	4.4%
336	Long QT Syndrome	4.3%
337	Tricuspid Atresia	4.3%
338	Arrhythmogenic Right Ventricular Dysplasia	4.3%
339	Gonadal Dysgenesis	4.3%
340	Adrenogenital Syndrome	4.3%
341	Ovotesticular Disorders of Sex Development	4.3%
342	Neoplastic Syndromes, Hereditary	4.3%
343	Shoulder Pain	4.2%
344	Refsum Disease	4.2%
345	Aortopulmonary Septal Defect	4.1%
346	Double Outlet Right Ventricle	4.1%
347	Endocardial Cushion Defects	4.1%
348	Myocardial bridging	4.1%
349	Aorticopulmonary Septal Defect	4.1%
350	Anemia, Neonatal	4.1%
351	Pelger-Huet Anomaly	4.1%
352	Persistent Fetal Circulation Syndrome	4.1%
353	Werner Syndrome	4.1%
354	Myasthenic Syndromes, Congenital	4.1%
355	Umbilical hernia	4%
356	Anemia, Sickle Cell	3.8%
357	Thalassemia	3.8%
358	Nose Neoplasms	3.7%
359	Mitochondrial Encephalomyopathies	3.7%
360	Truncus Arteriosus, Persistent	3.7%
361	Albinism	3.7%
362	Renal Osteodystrophy	3.6%
363	Renal rickets	3.6%
364	Romano-Ward Syndrome	3.5%
365	Neonatal Abstinence Syndrome	3.5%
366	Fetal Growth Retardation	3.4%
367	Dermatomyositis	3.4%
368	Fetal Hypoxia	3.4%
369	Congenital nystagmus	3.4%
370	Fetal Alcohol Spectrum Disorders	3.4%
371	Familial Mediterranean Fever	3.4%
372	Toxoplasmosis, Congenital	3.3%
373	Syphilis, Congenital	3.3%
374	Rett Syndrome	3.3%
375	Mucopolysaccharidosis II	3.2%
376	Menkes Kinky Hair Syndrome	3%
377	Familial Hypophosphatemic Rickets	3%
378	Wiskott-Aldrich Syndrome	2.9%
379	Autoimmune Lymphoproliferative Syndrome	2.9%
380	Congenital Hyperinsulinism	2.9%
381	Chorioamnionitis	2.9%
382	Angioedemas, Hereditary	2.9%
383	Sickle Cell Trait	2.8%
384	Arteriovenous fistula	2.7%
385	Paralysis, Obstetric	2.7%
386	Retinopathy of Prematurity	2.7%
387	MELAS Syndrome	2.7%
388	Amino Acid Metabolism, Inborn Errors	2.7%
389	Carbohydrate Metabolism, Inborn Errors	2.7%
390	Metal Metabolism, Inborn Errors	2.7%
391	Progeria	2.7%
392	Lysosomal Storage Diseases	2.7%
393	Cytochrome-c Oxidase Deficiency	2.7%
394	Peroxisomal Disorders	2.7%
395	Neuronal Ceroid-Lipofuscinoses	2.7%
396	Bronchopulmonary Dysplasia	2.7%
397	Adrenoleukodystrophy	2.5%
398	Radicular Cyst	2.5%
399	Hepatolenticular Degeneration	2.4%
400	Fabry Disease	2.3%
401	Amyloid Neuropathies, Familial	2.3%
402	Respiratory Distress Syndrome, Newborn	2.3%
403	Denys-Drash Syndrome	2.3%
404	Cutis Laxa	2.3%
405	Retinitis Pigmentosa	2.2%
406	Pigmentary retinopathy	2.2%
407	Porokeratosis	2.2%
408	Keratoderma, Palmoplantar	2.2%
409	Acute Chest Syndrome	2.2%
410	Chronic granulomatous disease	2.2%
411	Glycogen storage disease type II	2.2%
412	Ophthalmia Neonatorum	2.2%
413	Galactosemias	2.2%
414	Urea Cycle Disorders, Inborn	2.2%
415	Tyrosinemias	2.2%
416	Hydrops Fetalis	2.2%
417	Mucopolysaccharidosis III	2%
418	Ataxia Telangiectasia	2%
419	Alkaptonuria	2%
420	Glycogen Storage Disease	2%
421	Hypophosphatasia	2%
422	Propionic acidemia	2%
423	Dihydropyrimidine Dehydrogenase Deficiency	2%
424	Cystinosis	2%
425	Optic Atrophy, Hereditary, Leber	2%
426	Hyperphosphaturia	2%
427	Duane Retraction Syndrome	2%
428	Porphyrias, Hepatic	1.9%
429	Canavan Disease	1.9%
430	Alexander Disease	1.9%
431	Peutz-Jeghers Syndrome	1.9%
432	Thrombasthenia	1.9%
433	Antithrombin III Deficiency	1.9%
434	Protein C Deficiency	1.9%
435	Brain Diseases, Metabolic, Inborn	1.9%
436	Afibrinogenemia	1.9%
437	Dystonia Musculorum Deformans	1.9%
438	Factor VII Deficiency	1.9%
439	Factor X Deficiency	1.9%
440	Factor XII Deficiency	1.9%
441	Hemophilia A	1.9%
442	Leukomalacia, Periventricular	1.9%
443	Activated Protein C Resistance	1.9%
444	Factor II deficiency	1.9%
445	Factor VIII Deficiency	1.9%
446	Factor V deficiency	1.9%
447	Factor XI Deficiency	1.9%
448	Hypoprothrombinemias	1.9%
449	Fanconi Anemia	1.9%
450	Nesidioblastosis	1.9%
451	Lafora Disease	1.9%
452	Unverricht-Lundborg Syndrome	1.9%
453	Anemia, Diamond-Blackfan	1.9%
454	Homocystinuria	1.8%
455	Gaucher Disease	1.8%
456	Leigh Disease	1.8%
457	Kearns-Sayre syndrome	1.7%
458	Multiple Endocrine Neoplasia	1.7%
459	Dermatitis, Atopic	1.7%
460	Hyaline Membrane Disease	1.7%
461	Hypolipoproteinemias	1.6%
462	Papillon-Lefevre Disease	1.6%
463	Glycogen Storage Disease Type I	1.6%
464	Glycogen Storage Disease Type V	1.6%
465	Hyperlipidemia, Familial Combined	1.6%
466	Tay-Sachs Disease	1.6%
467	Hyperlipoproteinemia Type III	1.6%
468	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
469	Niemann-Pick Disease, Type C	1.6%
470	Kernicterus	1.5%
471	Behcet Syndrome	1.5%
472	Lactose Intolerance	1.4%
473	Variegate Porphyria	1.4%
474	Acute intermittent porphyria	1.4%
475	Porphyria Cutanea Tarda	1.4%
476	Hyperhomocysteinemia	1.4%
477	Renal Aminoacidurias	1.4%
478	Fanconi Syndrome	1.4%
479	Pseudohypoaldosteronism	1.4%
480	Liddle Syndrome	1.4%
481	Hyperlipoproteinemia Type IV	1.4%
482	Hyperlipoproteinemia Type V	1.4%
483	Hypoalphalipoproteinemias	1.4%
484	Huntington Disease	1.3%
485	Multiple Endocrine Neoplasia Type 1	1.2%
486	Friedreich Ataxia	1.2%
487	Renal tubular acidosis	1.2%
488	Nephroblastoma	1.2%
489	Cystinuria	1.2%
490	Adenomatous Polyposis Coli	1.1%
491	Glycosuria, Renal	1%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234