MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Aortic Valve Stenosis

(UMLS:C0003507)

Definition:: A pathological constriction that can occur above (supravalvular stenosis), below (subvalvular stenosis), or at the AORTIC VALVE. It is characterized by restricted outflow from the LEFT VENTRICLE into the AORTA.
UMLS ID:: C0003507
MeSH ID:: D001024

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.484.150|C14.280.955.249

Synonym(s)

Aortic Valve Stenosis

AORTIC STENOSIS

AORTIC VALVE STENOSIS

AORTIC VALVULAR STENOSIS

AS - Aortic stenosis

Aortic (valve) stenosis

Aortic Stenosis

Aortic stenosis

Aortic valve stenosis

10.

Aortic valve stenosis, NOS

11.

Aortic valve--Stenosis

12.

Narrowing of aortic valve

13.

Stenosed aortic valve

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	rofecoxib	FAERS: 52		US FAERS
2	Paroxetine	FAERS: 23		US FAERS
3	Rosiglitazone	FAERS: 23 Canada Vigilance: 1		Canada Vigilance US FAERS
4	Sertraline	FAERS: 11		US FAERS
5	apixaban	FAERS: 9		US FAERS
6	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 7		US FAERS
7	Dabigatran	FAERS: 6		US FAERS
8	Lenalidomide	FAERS: 6		SIDER US FAERS
9	Bosentan	FAERS: 5		US FAERS
10	Omeprazole	FAERS: 5		US FAERS
11	Valsartan	FAERS: 5		US FAERS
12	Teriparatide	FAERS: 4		US FAERS
13	paricalcitol	FAERS: 4		US FAERS
14	Celecoxib	FAERS: 3		US FAERS
15	Enalapril	FAERS: 3		US FAERS
16	Exenatide	FAERS: 3		US FAERS
17	Ibandronic Acid	FAERS: 3		US FAERS
18	Octreotide	FAERS: 3		US FAERS
19	Ondansetron	FAERS: 3		US FAERS
20	Tiotropium Bromide	FAERS: 3		US FAERS
21	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 2		US FAERS
22	AMG-416	FAERS: 2		US FAERS
23	Albuterol	FAERS: 2		US FAERS
24	Azacitidine	FAERS: 2		US FAERS
25	Clozapine	FAERS: 2		US FAERS
26	Fluoxetine	FAERS: 2		US FAERS
27	Glatiramer Acetate	FAERS: 2		US FAERS
28	Imatinib Mesylate	FAERS: 2		US FAERS
29	Letrozole	FAERS: 2		US FAERS
30	Paroxetine	FAERS: 2		US FAERS
31	Pergolide	FAERS: 2		US FAERS
32	Prednisolone	FAERS: 2		US FAERS
33	Ramipril	FAERS: 2		US FAERS
34	Tacrolimus	FAERS: 2		US FAERS
35	Tamoxifen	FAERS: 2		US FAERS
36	Testosterone	FAERS: 2		US FAERS
37	Tolvaptan	FAERS: 2		US FAERS
38	Zoledronic Acid	FAERS: 2		US FAERS
39	bicalutamide	FAERS: 2		US FAERS
40	Atomoxetine Hydrochloride	FAERS: 1		US FAERS
41	Axitinib	FAERS: 1		US FAERS
42	Carbamazepine	FAERS: 1		US FAERS
43	Cyclosporine	FAERS: 1		US FAERS
44	Dabigatran	FAERS: 1		US FAERS
45	Dasatinib	FAERS: 1		US FAERS
46	Deamino Arginine Vasopressin	FAERS: 1		US FAERS
47	Deamino Arginine Vasopressin	FAERS: 1		US FAERS
48	Dexfenfluramine	FAERS: 1		US FAERS
49	Donepezil	FAERS: 1		US FAERS
50	Ergocalciferols	FAERS: 1		US FAERS
51	Ezetimibe, Simvastatin Drug Combination	FAERS: 1		US FAERS
52	Fentanyl	FAERS: 1		US FAERS
53	Fluoxetine	FAERS: 1		US FAERS
54	Fluticasone-Salmeterol Drug Combination	FAERS: 1		US FAERS
55	Iloprost	FAERS: 1		US FAERS
56	LCZ 696	FAERS: 1		US FAERS
57	Lamotrigine	FAERS: 1		US FAERS
58	Levetiracetam	FAERS: 1		US FAERS
59	Linagliptin	FAERS: 1		US FAERS
60	MDV 3100	FAERS: 1		US FAERS
61	Metformin	FAERS: 1		US FAERS
62	Methotrexate	FAERS: 1		US FAERS
63	Mitoxantrone	FAERS: 1		US FAERS
64	Pergolide	FAERS: 1		US FAERS
65	Pioglitazone	FAERS: 1		US FAERS
66	Ranolazine	FAERS: 1		US FAERS
67	Rivaroxaban	FAERS: 1		US FAERS
68	Sildenafil Citrate	FAERS: 1		US FAERS
69	Sitagliptin Phosphate	FAERS: 1		US FAERS
70	Telmisartan	FAERS: 1		US FAERS
71	Thalidomide	FAERS: 1		US FAERS
72	Ticagrelor	FAERS: 1		US FAERS
73	Vardenafil Dihydrochloride	FAERS: 1		US FAERS
74	Warfarin	FAERS: 1		US FAERS
75	aclidinium bromide	FAERS: 1		US FAERS
76	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
77	edoxaban	FAERS: 1		US FAERS
78	empagliflozin	FAERS: 1		US FAERS
79	exemestane	FAERS: 1		US FAERS
80	gemcitabine	FAERS: 1		US FAERS
81	ponatinib	FAERS: 1		US FAERS
82	ropinirole	FAERS: 1		US FAERS
83	sofosbuvir-velpatasvir drug combination	FAERS: 1		US FAERS
84	telmisartan, hydrochlorothiazide drug combination	FAERS: 1		US FAERS
85	testosterone 17 beta-cypionate	FAERS: 1		US FAERS
86	6-N,N-diethyl-beta,gamma-dibromomethylene-D-ATP		22659116	CTD
87	Aspirin		4010751	CTD
88	Colesevelam Hydrochloride			SIDER
89	Diethylstilbestrol		830309	CTD
90	Dobutamine		8831400	CTD
91	Memantine			SIDER
92	Mestranol		830309	CTD
93	Naproxen			SIDER
94	Norethynodrel		830309	CTD
95	Phosphates		22659116	CTD
96	Pregabalin			SIDER
97	Progesterone		830309	CTD
98	Tolcapone			SIDER
99	argatroban			SIDER
100	ioversol			SIDER
101	lanreotide			SIDER
102	valdecoxib			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Pulmonary Valve Stenosis	66.7%
2	Aortic Valve Insufficiency	44.4%
3	Mitral Valve Insufficiency	44.4%
4	Mitral Valve Stenosis	44.4%
5	Pulmonary Valve Insufficiency	44.4%
6	Tricuspid Valve Insufficiency	44.4%
7	Tricuspid Valve Stenosis	44.4%
8	Myocardial Ischemia	41.4%
9	Cardiac Tamponade	40.9%
10	Endocarditis	40.9%
11	Cardiac Arrest	40.9%
12	Heart failure	40.9%
13	Pericardial effusion	40.9%
14	Pericarditis	40.9%
15	Pneumopericardium	40.9%
16	Cor pulmonale	40.9%
17	Ventricular Dysfunction	40.9%
18	Cardiomyopathies	40.9%
19	Pleuropericarditis	40.9%
20	Cardiomyopathy, Dilated	40%
21	Tricuspid Atresia	39.8%
22	Aortic Valve Prolapse	33%
23	Tricuspid Valve Prolapse	33%
24	Heart Block	32%
25	Tachycardia	32%
26	Tachyarrhythmia	32%
27	Cardiac Output, High	31%
28	Myocardial Stunning	31%
29	Low Cardiac Output Syndrome	31%
30	Arrhythmogenic Right Ventricular Dysplasia	30.9%
31	Cardiomegaly	30.5%
32	Postpericardiotomy Syndrome	30.5%
33	Cardiac Hypertrophy	30.5%
34	Myocardial Reperfusion Injury	30.3%
35	Rheumatic Heart Disease	30.1%
36	Lown-Ganong-Levine Syndrome	29.5%
37	Restrictive cardiomyopathy	26.7%
38	Coronary heart disease	26.7%
39	Endocardial Fibroelastosis	26.7%
40	Heart Rupture, Post-Infarction	26.7%
41	Myocardial Infarction	26.7%
42	Myocarditis	26.7%
43	Pericarditis, Constrictive	26.7%
44	Ventricular Dysfunction, Left	26.7%
45	Right Ventricular Dysfunction	26.7%
46	Endomyocardial Fibrosis	26.7%
47	Carditis	26.7%
48	Acute Coronary Syndrome	26.7%
49	Heart Failure, Systolic	26.7%
50	Heart Failure, Diastolic	26.7%
51	Long QT Syndrome	26.5%
52	Hypertrophic Cardiomyopathy	25.9%
53	Hypertrophic obstructive cardiomyopathy	25.9%
54	Sick Sinus Syndrome	25.1%
55	Vascular Diseases	23.8%
56	Adams-Stokes Syndrome	23.5%
57	Atrioventricular Block	23.5%
58	Bundle-Branch Block	23.5%
59	Atrial Premature Complexes	23.5%
60	Sinoatrial Block	23.5%
61	Tachycardia, Paroxysmal	23.5%
62	Supraventricular tachycardia	23.5%
63	Tachycardia, Ventricular	23.5%
64	Wolff-Parkinson-White Syndrome	23.5%
65	Tachycardia, Reciprocating	23.5%
66	Kounis Syndrome	21.6%
67	Aortic coarctation	21.2%
68	Cor Triatriatum	21.2%
69	Coronary Vessel Anomalies	21.2%
70	Patent ductus arteriosus	21.2%
71	Ebstein Anomaly	21.2%
72	Heart Septal Defects	21.2%
73	Tetralogy of Fallot	21.2%
74	Transposition of Great Vessels	21.2%
75	Hypoplastic Left Heart Syndrome	21.2%
76	Angina Pectoris	21.1%
77	Coronary Aneurysm	21.1%
78	Bacterial Endocarditis	20.5%
79	Ventricular Outflow Obstruction	20.5%
80	Aortic Valve Stenosis	20%
81	Sinus Arrhythmia	20%
82	Atrial Fibrillation	20%
83	Atrial Flutter	20%
84	Edema, Cardiac	20%
85	Ventricular Fibrillation	20%
86	Ventricular Flutter	20%
87	Parasystole	20%
88	Paroxysmal atrial fibrillation	20%
89	Bradycardia	20%
90	Diabetic Cardiomyopathies	20%
91	Cardiomyopathy, Alcoholic	19.8%
92	Sudden Cardiac Death	19.8%
93	Left Ventricular Hypertrophy	19.8%
94	Right Ventricular Hypertrophy	19.8%
95	Takotsubo Cardiomyopathy	19.8%
96	Chagas Cardiomyopathy	19.8%
97	Coronary Occlusion	19.7%
98	Microvascular Angina	19.7%
99	Coronary Stenosis	19.7%
100	ST segment elevation myocardial infarction	19.7%
101	Coronary Thrombosis	19.6%
102	Coronary Artery Disease	19.6%
103	Carcinoid Heart Disease	19.6%
104	Romano-Ward Syndrome	19.5%
105	Tachycardia, Atrioventricular Nodal Reentry	19.4%
106	Tachycardia, Ectopic Atrial	19.4%
107	Tachycardia, Ectopic Junctional	19.4%
108	Sinus Tachycardia	19.4%
109	Torsades de Pointes	19.4%
110	Accelerated Idioventricular Rhythm	19.4%
111	Pregnancy Complications, Cardiovascular	17.9%
112	Cardiovascular Abnormalities	17.9%
113	Dextrocardia	17.7%
114	Coronary Restenosis	16.3%
115	Dyspnea, Paroxysmal	15.9%
116	Shock, Cardiogenic	15.8%
117	Aortopulmonary Septal Defect	15.6%
118	Double Outlet Right Ventricle	15.6%
119	Endocardial Cushion Defects	15.6%
120	Myocardial bridging	15.6%
121	Aorticopulmonary Septal Defect	15.6%
122	Angina, Unstable	15.6%
123	Supravalvular aortic stenosis	14.8%
124	Sinus Arrest, Cardiac	14.8%
125	Aneurysm	13.6%
126	Angiomatosis	13.6%
127	Aortic Diseases	13.6%
128	Arterial Occlusive Diseases	13.6%
129	Hyperemia	13.6%
130	Hypotension	13.6%
131	Superior Vena Cava Syndrome	13.6%
132	Telangiectasis	13.6%
133	Vasculitis	13.6%
134	Venous Insufficiency	13.6%
135	Peripheral Vascular Diseases	13.6%
136	Embolism and Thrombosis	13.6%
137	Angiodysplasia	13.6%
138	Capillary Leak Syndrome	13.6%
139	Prehypertension	13.6%
140	Aortic Aneurysm	13.3%
141	Aortitis	13.3%
142	Leriche Syndrome	13.3%
143	Noonan Syndrome	13.3%
144	Periphlebitis	13.3%
145	Phlebitis	13.3%
146	Thromboangiitis Obliterans	13.3%
147	Truncus Arteriosus, Persistent	12.9%
148	Angina Pectoris, Variant	12.9%
149	Subacute Bacterial Endocarditis	12.2%
150	Embolism, Amniotic Fluid	12.1%
151	Marfan Syndrome	12%
152	Postphlebitic Syndrome	11.6%
153	Retinal Vein Occlusion	11.5%
154	Arteriovenous fistula	11.5%
155	Thrombophlebitis	11.1%
156	Vascular System Injuries	10.7%
157	Malignant Atrophic Papulosis	10.7%
158	Shwartzman Phenomenon	10.6%
159	May-Thurner Syndrome	10.6%
160	Compartment syndromes	10.3%
161	Hepatic Veno-Occlusive Disease	10.3%
162	Peliosis Hepatis	10.3%
163	Varicocele	10.3%
164	Blue Toe Syndrome	10.3%
165	Cerebrovascular Disorders	10.2%
166	Diabetic Angiopathies	10.2%
167	Reperfusion Injury	10.2%
168	Splenic Infarction	10.2%
169	Cerebrovascular Insufficiency	10.2%
170	Vascular Neoplasms	10.2%
171	Spinal Cord Vascular Diseases	10.2%
172	Vasoplegia	10.2%
173	Hemorrhoids	10.1%
174	Thoracic Outlet Syndrome	10.1%
175	Aortic Rupture	9.9%
176	Aortic Aneurysm, Abdominal	9.8%
177	Aortic Aneurysm, Thoracic	9.8%
178	Intracranial Embolism and Thrombosis	9.2%
179	Carotid Artery Thrombosis	9.2%
180	Carotid Stenosis	9.2%
181	Intracranial Aneurysm	9.2%
182	Aneurysm, Dissecting	8.9%
183	Arteriosclerosis	8.9%
184	Arteritis	8.9%
185	Embolism	8.9%
186	Erythromelalgia	8.9%
187	Fibromuscular Dysplasia	8.9%
188	Malignant Hypertension	8.9%
189	Raynaud Disease	8.9%
190	Thromboembolism	8.9%
191	Thrombosis	8.9%
192	Essential Hypertension	8.9%
193	Aneurysm, Ruptured	8.9%
194	Iliac Aneurysm	8.9%
195	Pulmonary artery stenosis	8.9%
196	White Coat Hypertension	8.9%
197	Systemic Vasculitis	8.9%
198	Embolus	8.9%
199	Moyamoya Disease	8.8%
200	Scimitar Syndrome	8.5%
201	Hand-Arm Vibration Syndrome	8.5%
202	Optic Neuropathy, Ischemic	8.2%
203	Anterior Ischemic Optic Neuropathy	8.2%
204	Mesenteric vascular insufficiency	8.2%
205	Angioedema	8%
206	Colitis, Ischemic	8%
207	Polyarteritis Nodosa	7.9%
208	Takayasu Arteritis	7.9%
209	Intracranial Arteriosclerosis	7.8%
210	Cerebral Atherosclerosis	7.8%
211	Cerebral Arteriosclerosis	7.8%
212	Vasculitis, Central Nervous System	7.7%
213	Cerebral Thrombosis	7.1%
214	Intracranial Embolism	7.1%
215	Intracranial Thrombosis	7.1%
216	Turner Syndrome	6.9%
217	Retinal Artery Occlusion	6.8%
218	Retinal Vasculitis	6.8%
219	Hypertensive Retinopathy	6.8%
220	Anterior Compartment Syndrome	6.7%
221	Vasculitis, Leukocytoclastic, Cutaneous	6.7%
222	Gastric Antral Vascular Ectasia	6.7%
223	Abdominal Compartment Syndrome	6.7%
224	Carotid Artery Diseases	6.6%
225	Brain Ischemia	6.6%
226	Ectopia Cordis	6.6%
227	Hypotension, Orthostatic	6.6%
228	Cerebrovascular accident	6.6%
229	Varicose Ulcer	6.6%
230	Vasospasm, Intracranial	6.6%
231	Spinal Cord Ischemia	6.6%
232	Intracranial Arterial Diseases	6.6%
233	Primary Graft Dysfunction	6.6%
234	Single umbilical artery	6.6%
235	Post-Exercise Hypotension	6.6%
236	Arteriosclerosis Obliterans	6.6%
237	Atherosclerosis	6.6%
238	Air Embolism	6.6%
239	Endarteritis	6.6%
240	Venous Thrombosis	6.6%
241	Deep Vein Thrombosis	6.6%
242	Venous Thromboembolism	6.6%
243	Giant Cell Arteritis	6.5%
244	Temporal Arteritis	6.5%
245	Brain Infarction	6.5%
246	Kearns-Sayre syndrome	6.5%
247	Sinus Thrombosis, Intracranial	6.1%
248	Lemierre Syndrome	6%
249	Kartagener Syndrome	5.7%
250	Subarachnoid Hemorrhage, Traumatic	5.7%
251	Carotid Artery, Internal, Dissection	5.7%
252	CREST Syndrome	5.7%
253	Cavernous Sinus Thrombosis	5.6%
254	Sagittal Sinus Thrombosis	5.6%
255	Vertebral Artery Dissection	5.6%
256	Infarction, Middle Cerebral Artery	5.6%
257	Infarction, Anterior Cerebral Artery	5.6%
258	Infarction, Posterior Cerebral Artery	5.6%
259	Mesenteric Vascular Occlusion	5.4%
260	Mucocutaneous Lymph Node Syndrome	5.4%
261	Diabetic Retinopathy	5.4%
262	Sturge-Weber Syndrome	5.4%
263	Cerebral Infarction	5.4%
264	Brain Stem Infarctions	5.4%
265	Livedo Reticularis	5.3%
266	Renal hypertension	5.3%
267	Renal Artery Obstruction	5.3%
268	Renal Artery Stenosis	5.3%
269	Hemangioma, Cavernous	5.3%
270	Basal Ganglia Cerebrovascular Disease	5.3%
271	Vascular Headaches	5.2%
272	Scurvy	5.2%
273	Intermittent Claudication	5%
274	Pulmonary Embolism	5%
275	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	5%
276	No-Reflow Phenomenon	5%
277	Cerebral Arterial Diseases	4.9%
278	Vertebrobasilar Insufficiency	4.9%
279	Carotid Artery Injuries	4.9%
280	Anterior Spinal Artery Syndrome	4.9%
281	Basilar Artery Stenosis	4.9%
282	Vertebral Artery Stenosis	4.9%
283	Intracranial Hemorrhage, Hypertensive	4.9%
284	Transient Cerebral Ischemia	4.9%
285	Lateral Medullary Syndrome	4.8%
286	Dural Arteriovenous Fistula	4.5%
287	Ischemic contracture	4.4%
288	Basal Ganglia Hemorrhage	4.4%
289	Angioedemas, Hereditary	4.4%
290	Cryoglobulinemia	4.4%
291	Leukomalacia, Periventricular	4.4%
292	Diabetic Foot	4.4%
293	Hepatic Vein Thrombosis	4.2%
294	Budd-Chiari Syndrome	4.2%
295	Pulmonary Infarction	4.1%
296	Williams Syndrome	4.1%
297	Subclavian Steal Syndrome	4.1%
298	Hypertension, Renovascular	3.9%
299	Subarachnoid Hemorrhage	3.9%
300	Hypoxia-Ischemia, Brain	3.9%
301	Cerebral Hemorrhage	3.9%
302	Hereditary Angioedema Type III	3.9%
303	Hereditary Angioedema Types I and II	3.9%
304	Putaminal Hemorrhage	3.8%
305	Shy-Drager Syndrome	3.7%
306	Purpura, Hyperglobulinemic	3.7%
307	Dementia, Vascular	3.6%
308	Behcet Syndrome	3.3%
309	Waldenstrom Macroglobulinemia	3.3%
310	Multiple Myeloma	3.3%
311	Granulomatosis with polyangiitis	3.3%
312	Pituitary Apoplexy	3.3%
313	Cerebral Amyloid Angiopathy	3.2%
314	Lupus Vasculitis, Central Nervous System	3%
315	Ataxia Telangiectasia	3%
316	Pseudoxanthoma Elasticum	3%
317	Rheumatoid Vasculitis	2.8%
318	Hematoma, Subdural	2%
319	Hematoma, Epidural, Cranial	2%
320	Hematoma, Subdural, Intracranial	1.8%
321	Hematoma, Subdural, Chronic	1.8%
322	Hematoma, Subdural, Acute	1.8%
323	Brain Hemorrhage, Traumatic	1.8%
324	MELAS Syndrome	1.8%
325	Fabry Disease	1.4%

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