MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Malformations of Cortical Development

(UMLS:C1955869)

Definition:: Abnormalities in the development of the CEREBRAL CORTEX. These include malformations arising from abnormal neuronal and glial CELL PROLIFERATION or APOPTOSIS (Group I); abnormal neuronal migration (Group II); and abnormal establishment of cortical organization (Group III). Many INBORN METABOLIC BRAIN DISORDERS affecting CNS formation are often associated with cortical malformations. They are common causes of EPILEPSY and developmental delay.
UMLS ID:: C1955869
MeSH ID:: D054220

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.500.507

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.666.507

Synonym(s)

Malformations of Cortical Development

Associated Drug(s)

	Name	Reference(s)	Data Source
1	4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid	9006080	CTD
2	Bexarotene	9006080	CTD
3	Carmustine	View details 12199722 17572393 19174181 20461523	CTD
4	Copper	16337877	CTD
5	Isotretinoin	2278026 3465061	CTD
6	Lamotrigine	18166379	CTD
7	Melatonin	20461523	CTD
8	Propylthiouracil	28973696	CTD
9	Valproic Acid	18166379	CTD
10	Vigabatrin	17346254 18166379	CTD
11	Vitamin A	8180004	CTD
12	diethanolamine	18948303	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hydranencephaly	44.8%
2	Neural Tube Defects	44.8%
3	Tethered Cord Syndrome	44.8%
4	Iniencephaly	44.8%
5	Craniorachischisis	44.8%
6	Exencephaly	44.8%
7	Septo-Optic Dysplasia	44.8%
8	Dandy-Walker Syndrome	34.8%
9	Dural Arteriovenous Fistula	34.5%
10	Anencephaly	34.2%
11	Meningomyelocele	32.8%
12	Spina Bifida	32.8%
13	Central Nervous System Cysts	32.8%
14	Holoprosencephaly	28.1%
15	Aicardi's syndrome	27.7%
16	Dermal Sinus	27%
17	Spina Bifida Cystica	27%
18	Spina Bifida Occulta	27%
19	Meningocele	26.2%
20	Encephalocele	26.2%
21	Charcot-Marie-Tooth Disease	24.2%
22	Abnormalities, Drug-Induced	20.9%
23	Situs Inversus	20.9%
24	Smith-Magenis syndrome	20.5%
25	Alstrom Syndrome	20.2%
26	Beckwith-Wiedemann Syndrome	18.9%
27	Wolf-Hirschhorn Syndrome	18.9%
28	Cri-du-Chat Syndrome	18.4%
29	Down Syndrome	18.4%
30	Trisomy 21	18.4%
31	Eye Abnormalities	16.4%
32	Cardiovascular Abnormalities	16.4%
33	Skin Abnormalities	15.8%
34	Lymphatic Abnormalities	15.8%
35	Congenital Microtia	15.8%
36	Prader-Willi Syndrome	15.7%
37	Refsum Disease	15.5%
38	Rubinstein-Taybi Syndrome	15.5%
39	Congenital diaphragmatic hernia	15.4%
40	Cranial nerve diseases	14.6%
41	Demyelinating Diseases	14.6%
42	Demyelination	14.6%
43	Neuromuscular Diseases	14.6%
44	Chronobiology Disorders	14.6%
45	Multiple System Atrophy	14.1%
46	Motor Neuron Disease	14%
47	Prune Belly Syndrome	13.6%
48	Twins, Conjoined	13.6%
49	Mobius Syndrome	13.6%
50	Waardenburg Syndrome	13.6%
51	Ectodermal Dysplasia	13.5%
52	Aplasia Cutis Congenita	13.5%
53	Urogenital Abnormalities	13%
54	Stiff-Person Syndrome	12.6%
55	CHARGE Syndrome	12.3%
56	Meningoencephalitis	12.2%
57	Genetic Diseases, Inborn	12.2%
58	Spinal Muscular Atrophy	12.2%
59	Progressive Muscular Atrophy	12.2%
60	Encephalomyelitis	12.1%
61	Prion Diseases	12.1%
62	Autonomic Dysreflexia	12.1%
63	Complex Regional Pain Syndromes	12.1%
64	Polyradiculoneuropathy	12%
65	Polyradiculoneuritis	12%
66	Maxillofacial Abnormalities	11.9%
67	Parkinson Disease	11.8%
68	Dextrocardia	11.7%
69	Williams Syndrome	11.6%
70	Ocular Motility Disorders	11.6%
71	Cyclophoria	11.6%
72	Amyotrophic Lateral Sclerosis	11.5%
73	Trauma, Nervous System	11.3%
74	Striatonigral Degeneration	11.3%
75	Restless Legs Syndrome	11.3%
76	Ophthalmoplegic Migraine	11.2%
77	Dystonia Musculorum Deformans	11.1%
78	Marchiafava-Bignami Disease	11.1%
79	Nervous System Neoplasms	10.9%
80	Neurologic Manifestations	10.9%
81	Neurotoxicity Syndromes	10.9%
82	Cockayne Syndrome	10.9%
83	Kartagener Syndrome	10.8%
84	Lewy Body Disease	10.7%
85	Guillain-Barre Syndrome	10.7%
86	Subacute Combined Degeneration	10.7%
87	Causalgia	10.7%
88	Fragile X Syndrome	10.5%
89	Anophthalmos	10.3%
90	Anus, Imperforate	10.3%
91	Microphthalmos	10.3%
92	Nail-Patella Syndrome	10.3%
93	Limb Deformities, Congenital	10.3%
94	Craniofacial Abnormalities	10.3%
95	Myasthenic Syndromes, Congenital	10.3%
96	Anorectal Malformations	10.3%
97	Xeroderma	10.2%
98	Marfan Syndrome	10.2%
99	Bloom Syndrome	10.2%
100	Myelitis	10.2%
101	Progressive bulbar palsy	10.2%
102	Bulbar palsy	10.2%
103	Leukoencephalitis, Acute Hemorrhagic	10.1%
104	Pneumocephalus	10.1%
105	Poliomyelitis	10.1%
106	Lafora Disease	10%
107	Unverricht-Lundborg Syndrome	10%
108	Spinal Cord Injuries	10%
109	Miller Fisher Syndrome	10%
110	Progressive supranuclear palsy	9.9%
111	Peripheral Nerve Injuries	9.7%
112	Shy-Drager Syndrome	9.7%
113	Myasthenia Gravis	9.6%
114	Asterixis	9.6%
115	Ballismus	9.6%
116	POEMS Syndrome	9.4%
117	Epidural Abscess	9.4%
118	Olfactory Nerve Injuries	9.4%
119	MPTP Poisoning	9.3%
120	Brain Diseases	9.3%
121	Dysautonomia	9.3%
122	Meningitis	9.3%
123	Movement Disorders	9.3%
124	Pachymeningitis	9.3%
125	Spinal Cord Diseases	9.3%
126	Vagus Nerve Disorder	9.3%
127	Glossopharyngeal Neuralgia	9.3%
128	Abducens Nerve Diseases	9.3%
129	Heavy Metal Poisoning, Nervous System	9.3%
130	Neuromuscular Junction Diseases	9.3%
131	Tauopathies	9.3%
132	Trochlear Nerve Diseases	9.3%
133	Peripheral Nervous System Diseases	9.3%
134	Myelitis, Transverse	9.3%
135	Reflex Sympathetic Dystrophy	9.2%
136	Subdural Effusion	9.2%
137	Parkinsonian Disorders	9.2%
138	Nocturnal Myoclonus Syndrome	9.2%
139	Encephalomyelitis, Acute Disseminated	9.1%
140	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	9.1%
141	Fetal Diseases	9.1%
142	Huntington Disease	9%
143	Scimitar Syndrome	9%
144	Canavan Disease	8.9%
145	Alexander Disease	8.9%
146	Neuromyelitis Optica	8.9%
147	Polycystic Kidney Diseases	8.9%
148	Neuroleptic Malignant Syndrome	8.8%
149	Myelinolysis, Central Pontine	8.8%
150	Sleep Wake Disorders	8.8%
151	Myotonic Dystrophy	8.7%
152	Abnormalities, Radiation-Induced	8.6%
153	Opsoclonus-Myoclonus Syndrome	8.6%
154	Craniosynostosis	8.5%
155	Syndactyly	8.5%
156	Brachycephaly	8.5%
157	Ataxia Telangiectasia	8.5%
158	Lambert-Eaton Myasthenic Syndrome	8.4%
159	Myotonia Congenita	8.4%
160	Blepharophimosis	8.3%
161	Chronic Fatigue Syndrome	8.3%
162	Laryngostenosis	8.3%
163	Meige Syndrome	8.3%
164	Mouth Abnormalities	8.3%
165	Brachial Plexus Neuritis	8.3%
166	Neuralgic Amyotrophy	8.3%
167	Cerebral Ventriculitis	8.3%
168	Epilepsy, Post-Traumatic	8.2%
169	Friedreich Ataxia	8.2%
170	Sleep Disorders, Circadian Rhythm	8.2%
171	Esophageal Atresia	8.2%
172	Intestinal Atresia	8.2%
173	Horseshoe Kidney	8.2%
174	Pectus excavatum	8.2%
175	Klippel-Feil Syndrome	8.2%
176	Gastroschisis	8.2%
177	Synostosis	8.2%
178	Acrodermatitis	8.1%
179	Lymphangiectasis, Intestinal	8.1%
180	Gianotti-Crosti Syndrome	8.1%
181	Brain Injuries	8.1%
182	Facial Nerve Injuries	8.1%
183	Acrocephalosyndactylia	8.1%
184	Brain Neoplasms	8.1%
185	Multiple Sclerosis	8.1%
186	Spinal Cord Neoplasms	8.1%
187	Dyskinesia, Drug-Induced	8.1%
188	Leukoencephalopathy, Progressive Multifocal	8%
189	Hepatolenticular Degeneration	8%
190	Retinal Dysplasia	7.9%
191	Botulism	7.9%
192	Tarsal Tunnel Syndrome	7.9%
193	Cauda Equina Syndrome	7.9%
194	Posterior Leukoencephalopathy Syndrome	7.9%
195	Posterior reversible encephalopathy syndrome	7.9%
196	Aniridia	7.8%
197	Primary Ciliary Dyskinesia	7.8%
198	Leukomalacia, Periventricular	7.8%
199	Epidermolysis Bullosa	7.7%
200	Cerebellar Neoplasms	7.6%
201	Limbic Encephalitis	7.6%
202	Amelia	7.6%
203	Arachnodactyly	7.6%
204	Ectopia Cordis	7.6%
205	Ectromelia	7.6%
206	Hemimelia	7.6%
207	Noonan Syndrome	7.6%
208	Phocomelia	7.6%
209	Sirenomelia	7.6%
210	Polydactyly	7.6%
211	Brachydactyly	7.6%
212	Plagiocephaly	7.6%
213	Lower Extremity Deformities, Congenital	7.6%
214	Upper Extremity Deformities, Congenital	7.6%
215	Single umbilical artery	7.6%
216	Muscular Dystrophy	7.5%
217	Scrapie	7.5%
218	Central Cord Syndrome	7.5%
219	Congenital nystagmus	7.5%
220	Myoclonic Epilepsy	7.4%
221	Epilepsy, Temporal Lobe	7.4%
222	Epilepsy, Rolandic	7.4%
223	Benign Rolandic Epilepsy	7.4%
224	Lupus Vasculitis, Central Nervous System	7.4%
225	Smith-Lemli-Opitz Syndrome	7.4%
226	Presenile dementia	7.4%
227	Senile dementia	7.4%
228	Meningitis, Bacterial	7.4%
229	Meningitis, Fungal	7.4%
230	Turner Syndrome	7.4%
231	Chorea	7.3%
232	Acrodynia	7.3%
233	Horner Syndrome	7.3%
234	Central Nervous System Infection	7.3%
235	Myopathy	7.3%
236	Optic Neuropathy	7.3%
237	Ichthyosis, X-Linked	7.2%
238	Toxoplasmosis, Congenital	7.1%
239	Cystic Fibrosis	7.1%
240	Myasthenia Gravis, Autoimmune, Experimental	7%
241	Facial Nerve Diseases	7%
242	Craniocerebral Trauma	7%
243	Parasomnia	7%
244	Dyssomnias	7%
245	Juvenile Myoclonic Epilepsy	7%
246	Myoclonic Epilepsies, Progressive	7%
247	Poland Syndrome	7%
248	Dementia, Vascular	7%
249	Abdominal Cramps	7%
250	Amniotic Band Syndrome	7%
251	Arthrogryposis	7%
252	Asphyxia Neonatorum	7%
253	Choanal Atresia	7%
254	Infant, Premature, Diseases	7%
255	Tracheobronchomegaly	7%
256	Infantile Colic	7%
257	Laryngocele	7%
258	Brain Hemorrhage, Traumatic	7%
259	Jaw Abnormalities	6.9%
260	Cleft Palate	6.9%
261	Rett Syndrome	6.9%
262	Muscular Dystrophy, Duchenne	6.9%
263	Vestibulocochlear Nerve Diseases	6.9%
264	Choledochal Cyst	6.9%
265	Decerebrate State	6.9%
266	Hemiparesis	6.9%
267	Hermaphroditism	6.9%
268	Meningism	6.9%
269	Paresis	6.9%
270	Seizures	6.9%
271	Sensation Disorders	6.9%
272	Disorders of Sex Development	6.9%
273	Central Nervous System Neoplasms	6.9%
274	Complex partial seizures	6.9%
275	Monoparesis	6.9%
276	Neurogenic Inflammation	6.9%
277	Gait Disorders, Neurologic	6.9%
278	Neuromuscular Manifestations	6.9%
279	Adrenoleukodystrophy	6.9%
280	Brain Death	6.8%
281	Coma, Post-Head Injury	6.8%
282	Sweating, Gustatory	6.8%
283	Auriculotemporal Syndrome	6.8%
284	Tuberous Sclerosis	6.8%
285	Akinetic Mutism	6.8%
286	Anoxic Encephalopathy	6.8%
287	Arachnoiditis	6.8%
288	Basal Ganglia Diseases	6.8%
289	Brain Damage, Chronic	6.8%
290	Cerebellar Diseases	6.8%
291	Cryptorchidism	6.8%
292	Encephalitis	6.8%
293	Encephalomalacia	6.8%
294	Epilepsy	6.8%
295	Hydrocephalus	6.8%
296	Congenital Hydrocephalus	6.8%
297	Hypothalamic Diseases	6.8%
298	Aseptic Meningitis	6.8%
299	Neuritis	6.8%
300	Polyneuritis	6.8%
301	Radiculitis	6.8%
302	Syringomyelia	6.8%
303	Thalamic Diseases	6.8%
304	Intracranial Hypertension	6.8%
305	Polyneuropathy	6.8%
306	Mononeuritis	6.8%
307	Aura	6.8%
308	Leukoencephalopathy	6.8%
309	Essential Tremor	6.8%
310	Neuroaxonal Dystrophies	6.8%
311	Familial Tremor	6.8%
312	Headache Disorders	6.8%
313	Mononeuropathies	6.8%
314	Intracranial Hypotension	6.8%
315	Brachial Plexus Neuropathies	6.8%
316	Radiculopathy	6.8%
317	Mononeuropathy Multiplex	6.8%
318	Nerve Root Compression	6.8%
319	Hypospadias	6.8%
320	Brain Edema	6.8%
321	Brain Hypoxia	6.8%
322	Aqueductal Stenosis	6.8%
323	Pneumorrhachis	6.8%
324	Writer's Cramp	6.8%
325	Akathisia, Drug-Induced	6.8%
326	Brain Abscess	6.8%
327	Ophthalmoplegia	6.8%
328	External Ophthalmoplegia	6.8%
329	Creutzfeldt-Jakob disease	6.7%
330	Basal Ganglia Cerebrovascular Disease	6.7%
331	Brain Injuries, Diffuse	6.6%
332	Traumatic Brain Injury	6.6%
333	Cerebellar Ataxia	6.6%
334	Supratentorial Neoplasms	6.6%
335	Torticollis	6.6%
336	Multiple Sclerosis, Chronic Progressive	6.6%
337	Multiple Sclerosis, Relapsing-Remitting	6.6%
338	Amyloid Neuropathies, Familial	6.6%
339	Polycystic Kidney, Autosomal Dominant	6.5%
340	Tuberculosis, Meningeal	6.5%
341	Klinefelter Syndrome	6.3%
342	Carpal Tunnel Syndrome	6.3%
343	Vascular Headaches	6.3%
344	Vasculitis, Central Nervous System	6.3%
345	neurofibroma	6.3%
346	Hypoxia-Ischemia, Brain	6.3%
347	Sciatica	6.2%
348	Jet Lag Syndrome	6.2%
349	Tardive Dyskinesia	6.2%
350	Persistent Vegetative State	6.2%
351	Zellweger Syndrome	6.2%
352	Carotid Artery Injuries	6.2%
353	Amblyopia	6.2%
354	Paraneoplastic Cerebellar Degeneration	6.1%
355	Cerebrospinal Fluid Otorrhea	6.1%
356	Cerebrospinal Fluid Rhinorrhea	6.1%
357	Neuritis, Autoimmune, Experimental	6.1%
358	Gait Ataxia	6.1%
359	Aortic coarctation	6%
360	Cor Triatriatum	6%
361	Coronary Vessel Anomalies	6%
362	Dental Enamel Hypoplasia	6%
363	Patent ductus arteriosus	6%
364	Ebstein Anomaly	6%
365	Heart Septal Defects	6%
366	Hypodontia	6%
367	Macrostomia	6%
368	Microstomia	6%
369	Tetralogy of Fallot	6%
370	Transposition of Great Vessels	6%
371	Hypoplastic Left Heart Syndrome	6%
372	May-Thurner Syndrome	6%
373	Craniofacial Dysostosis	6%
374	Pseudoxanthoma Elasticum	6%
375	Wolff-Parkinson-White Syndrome	6%
376	Meconium Aspiration Syndrome	5.9%
377	Laryngomalacia	5.9%
378	Cubital Tunnel Syndrome	5.9%
379	Diffuse Axonal Injury	5.9%
380	Neuronal Ceroid-Lipofuscinoses	5.9%
381	Brain Stem Neoplasms	5.9%
382	Pectus carinatum	5.9%
383	Vocal Cord Paralysis	5.9%
384	Micrognathism	5.8%
385	Pierre Robin Syndrome	5.8%
386	Alice in Wonderland Syndrome	5.8%
387	Sjogren-Larsson Syndrome	5.8%
388	Bladder Exstrophy	5.8%
389	Epispadias	5.8%
390	Pituitary Adenoma	5.8%
391	Pituitary Neoplasms	5.8%
392	Multicystic Dysplastic Kidney	5.8%
393	Duane Retraction Syndrome	5.7%
394	Brain Concussion	5.7%
395	Pupil Disorders	5.7%
396	Neurobehavioral Manifestations	5.7%
397	Menkes Kinky Hair Syndrome	5.7%
398	Optic Atrophy, Hereditary, Leber	5.7%
399	Welander Distal Myopathy	5.6%
400	Antley-Bixler Syndrome Phenotype	5.6%
401	Cerebral Palsy	5.6%
402	Epilepsies, Partial	5.6%
403	Epilepsy, Generalized	5.6%
404	Pseudotumor Cerebri	5.6%
405	Sciatic Neuropathy	5.6%
406	Hypertensive Encephalopathy	5.6%
407	Ulnar Neuropathies	5.6%
408	Lesion of Sciatic Nerve	5.6%
409	Simple Partial Seizures	5.6%
410	Epilepsy, Reflex	5.6%
411	Ulnar Neuritis	5.6%
412	Radial nerve compression	5.6%
413	Radial Tunnel Syndrome	5.6%
414	Peroneal Neuropathies	5.6%
415	Radial Neuropathy	5.6%
416	Median Neuropathy	5.6%
417	Sciatic Nerve Palsy	5.6%
418	Femoral Neuropathy	5.6%
419	Tibial Neuropathy	5.6%
420	Ulnar Nerve Palsy	5.6%
421	Postural Orthostatic Tachycardia Syndrome	5.6%
422	Radial nerve palsy	5.6%
423	Headache Disorders, Primary	5.6%
424	Headache Disorders, Secondary	5.6%
425	Medication overuse headache	5.6%
426	Kallmann Syndrome	5.6%
427	Paraneoplastic Encephalomyelitis	5.6%
428	Choroid Plexus Papilloma	5.5%
429	Hyperkeratosis, Epidermolytic	5.5%
430	Uveomeningoencephalitic Syndrome	5.5%
431	Neoplastic Syndromes, Hereditary	5.5%
432	Sturge-Weber Syndrome	5.4%
433	Vertigo	5.4%
434	Alcohol-Induced Disorders, Nervous System	5.4%
435	Xeroderma Pigmentosum	5.4%
436	Basal Ganglia Hemorrhage	5.4%
437	Toxoplasmosis, Cerebral	5.3%
438	Optic Nerve Glioma	5.3%
439	Meningitis, Cryptococcal	5.2%
440	Meningitis, Listeria	5.2%
441	Retrognathia	5.2%
442	Akathisia	5.2%
443	Restlessness	5.2%
444	Psychomotor Agitation	5.2%
445	Meningitis, Haemophilus	5.2%
446	Meningitis, Pneumococcal	5.2%
447	Frontotemporal dementia	5.2%
448	Anemia, Neonatal	5.2%
449	Brain Diseases, Metabolic	5.2%
450	Cerebrovascular Disorders	5.2%
451	Multiple Epiphyseal Dysplasia	5.2%
452	Myositis	5.2%
453	Optic Atrophy	5.2%
454	Optic Neuritis	5.2%
455	Osteochondrodysplasias	5.2%
456	Papilledema	5.2%
457	Pelger-Huet Anomaly	5.2%
458	Persistent Fetal Circulation Syndrome	5.2%
459	Strabismus	5.2%
460	Tolosa-Hunt Syndrome	5.2%
461	Werner Syndrome	5.2%
462	Cerebrovascular Insufficiency	5.2%
463	Isaacs syndrome	5.2%
464	Arsenic Poisoning	5.2%
465	Dementia	5.2%
466	Myotonic Disorders	5.2%
467	Central Nervous System Fungal Infections	5.2%
468	Conus Medullaris Syndrome	5.2%
469	Spinal Cord Vascular Diseases	5.2%
470	Umbilical hernia	5.1%
471	Diabetic Neuropathies	5.1%
472	Facial Injuries	5.1%
473	Facial Neuralgia	5.1%
474	Diabetic Amyotrophy	5.1%
475	Diabetic Autonomic Neuropathy	5.1%
476	Sleep Talking	5.1%
477	Manganese Poisoning	5.1%
478	Sleep Disorders, Intrinsic	5.1%
479	Orthostatic intolerance	5.1%
480	Putaminal Hemorrhage	5.1%
481	Familial Periodic Paralysis	5.1%
482	Anosmia	5%
483	Ataxia	5%
484	Athetosis	5%
485	Catalepsy	5%
486	Dystonia	5%
487	Hemiplegia	5%
488	Locked-In Syndrome	5%
489	Meningeal Neoplasms	5%
490	Muscle Hypertonia	5%
491	Muscle hypotonia	5%
492	Myoclonus	5%
493	Myotonia	5%
494	Neuralgia	5%
495	Paraplegia	5%
496	Pseudobulbar Palsy	5%
497	Quadriplegia	5%
498	Spasm	5%
499	Spastic Paraplegia	5%
500	Status Epilepticus	5%
501	Taste Disorders	5%
502	Tremor	5%
503	Monoplegia	5%
504	Hypokinesia	5%
505	Paraparesis	5%
506	Bradykinesia	5%
507	Waxy flexibility	5%
508	Action Tremor	5%
509	Resting Tremor	5%
510	Dysosmia	5%
511	Quadriparesis	5%
512	Mercury Poisoning, Nervous System	5%
513	Olfaction Disorders	5%
514	Myokymia	5%
515	Lead Poisoning, Nervous System	5%
516	Vestibular Neuronitis	5%
517	Somatosensory Disorders	5%
518	Neuropathic pain	5%
519	Hyperkinesia	5%
520	Intention tremor	5%
521	Infarction, Middle Cerebral Artery	5%
522	Infarction, Anterior Cerebral Artery	5%
523	Infarction, Posterior Cerebral Artery	5%
524	Long QT Syndrome	5%
525	Platybasia	5%
526	Polyradiculopathy	5%
527	Post-Traumatic Headache	5%
528	Tension Headache	5%
529	Epilepsy, Complex Partial	5%
530	Migraine Disorders	5%
531	Tricuspid Atresia	5%
532	Abdominal Migraine	5%
533	Status Migrainosus	5%
534	Arrhythmogenic Right Ventricular Dysplasia	5%
535	Cervicogenic Headache	5%
536	Brain Diseases, Metabolic, Inborn	5%
537	Mucopolysaccharidosis II	5%
538	Gonadal Dysgenesis	5%
539	Pituitary Apoplexy	5%
540	Bronchomalacia	5%
541	Adrenogenital Syndrome	5%
542	Tracheomalacia	5%
543	Ovotesticular Disorders of Sex Development	5%
544	Alcohol Withdrawal Seizures	5%
545	Vertebral Artery Dissection	5%
546	Microcephaly	5%
547	Macrocephaly	5%
548	Aortopulmonary Septal Defect	5%
549	Double Outlet Right Ventricle	5%
550	Endocardial Cushion Defects	5%
551	Myocardial bridging	5%
552	Aorticopulmonary Septal Defect	5%
553	Amnesia, Transient Global	4.9%
554	Brain Contusion	4.9%
555	Gait Apraxia	4.9%
556	Brain Infarction	4.9%
557	Subacute Sclerosing Panencephalitis	4.9%
558	Hyperandrogenism	4.9%
559	MELAS Syndrome	4.9%
560	Subarachnoid Hemorrhage, Traumatic	4.9%
561	Carotid Artery, Internal, Dissection	4.9%
562	Basal Cell Nevus Syndrome	4.8%
563	Mitochondrial Encephalomyopathies	4.7%
564	Cluster Headache	4.7%
565	Migraine with Aura	4.7%
566	Familial Hemiplegic Migraine	4.7%
567	Chronic Paroxysmal Hemicrania	4.7%
568	SUNCT Syndrome	4.7%
569	Paroxysmal Hemicrania	4.7%
570	Prognathism	4.7%
571	Voice Disorders	4.7%
572	Voice Disturbance	4.7%
573	Cerebral Infarction	4.6%
574	Brain Stem Infarctions	4.6%
575	Familial Mediterranean Fever	4.5%
576	Anemia, Sickle Cell	4.5%
577	Thalassemia	4.5%
578	Lateral Medullary Syndrome	4.5%
579	Fabry Disease	4.4%
580	Pituitary Diseases	4.4%
581	Truncus Arteriosus, Persistent	4.4%
582	Goldenhar Syndrome	4.4%
583	Galactosemias	4.3%
584	Urea Cycle Disorders, Inborn	4.3%
585	Tyrosinemias	4.3%
586	Dwarfism	4.3%
587	Hand-Arm Vibration Syndrome	4.3%
588	Thoracic Outlet Syndrome	4.3%
589	Neonatal Abstinence Syndrome	4.2%
590	Carotid Artery Diseases	4.2%
591	Brain Ischemia	4.2%
592	Esotropia	4.2%
593	Exotropia	4.2%
594	Hypotension, Orthostatic	4.2%
595	Sleep Apnea Syndromes	4.2%
596	Cerebrovascular accident	4.2%
597	Polymyositis	4.2%
598	Kluver-Bucy Syndrome	4.2%
599	Vasospasm, Intracranial	4.2%
600	Spinal Cord Ischemia	4.2%
601	Intracranial Arterial Diseases	4.2%
602	Post-Exercise Hypotension	4.2%
603	Alexia	4.2%
604	Vision Disorders	4.2%
605	Metamorphopsia	4.2%
606	Dyslexia	4.2%
607	Visual Impairment	4.2%
608	Fibromyalgia	4.2%
609	Disorders of Excessive Somnolence	4.2%
610	Sleep Initiation and Maintenance Disorders	4.2%
611	Night Terrors	4.2%
612	Somnambulism	4.2%
613	Trigeminal Nerve Disorder	4.2%
614	Optic Neuropathy, Ischemic	4.2%
615	Transient Insomnia	4.2%
616	Sleep Paralysis	4.2%
617	Chronic Insomnia	4.2%
618	Anterior Ischemic Optic Neuropathy	4.2%
619	REM Sleep Behavior Disorder	4.2%
620	Central Nervous System Bacterial Infections	4.2%
621	Hypersomnia	4.2%
622	Medial Tibial Stress Syndrome	4.2%
623	Dysgeusia	4.1%
624	Formication	4.1%
625	Hyperalgesia	4.1%
626	Hyperesthesia	4.1%
627	Hypesthesia	4.1%
628	Language Disorders	4.1%
629	Numbness	4.1%
630	Paresthesia	4.1%
631	Paraparesis, Spastic	4.1%
632	Trismus	4.1%
633	Epilepsia Partialis Continua	4.1%
634	Hypogeusia	4.1%
635	Meningeal Carcinomatosis	4.1%
636	Brown-Sequard Syndrome	4.1%
637	Lockjaw	4.1%
638	Allodynia	4.1%
639	Lead Poisoning, Nervous System, Childhood	4.1%
640	Lead Poisoning, Nervous System, Adult	4.1%
641	Ageusia	4.1%
642	Tuberculosis, Central Nervous System	4.1%
643	West Nile Fever	4.1%
644	Auditory Perceptual Disorders	4.1%
645	Hypokalemic periodic paralysis	4.1%
646	Mandibulofacial Dysostosis	4.1%
647	Facial Hemiatrophy	4.1%
648	Fetal Growth Retardation	4.1%
649	Melkersson-Rosenthal Syndrome	4.1%
650	Romano-Ward Syndrome	4.1%
651	Mitochondrial Myopathies	4.1%
652	Porencephaly	4.1%
653	Moyamoya Disease	4.1%
654	Albinism	4.1%
655	Anisocoria	4.1%
656	Confusion	4.1%
657	Facial paralysis	4.1%
658	Lethargy	4.1%
659	Memory Disorders	4.1%
660	Muscle Cramp	4.1%
661	Osteogenesis Imperfecta	4.1%
662	Perceptual Disorders	4.1%
663	Psychomotor Disorders	4.1%
664	Tonic Pupil	4.1%
665	Eosinophilia-Myalgia Syndrome	4.1%
666	Anhedonia	4.1%
667	Disorientation	4.1%
668	Fetal Hypoxia	4.1%
669	Facial Paresis	4.1%
670	Memory Loss	4.1%
671	Hemisensory Neglect	4.1%
672	Dysacusis	4.1%
673	Fetal Alcohol Spectrum Disorders	4.1%
674	Sleep Bruxism	4.1%
675	Neurofibrosarcoma	4.1%
676	Muscular Atrophy	4%
677	Respiratory Paralysis	4%
678	Syphilis, Congenital	4%
679	Tetany	4%
680	Giant Cell Arteritis	3.8%
681	Temporal Arteritis	3.8%
682	Empty Sella Syndrome	3.8%
683	Hyperpituitarism	3.8%
684	Hypopituitarism	3.8%
685	Hypophysitis	3.8%
686	Reflex, Abnormal	3.8%
687	Hyporeflexia	3.8%
688	Hyperreflexia	3.8%
689	Kernicterus	3.8%
690	Glycogen storage disease type II	3.8%
691	Hematoma, Subdural	3.8%
692	Hematoma, Epidural, Cranial	3.8%
693	Cerebral Arterial Diseases	3.7%
694	Vertebrobasilar Insufficiency	3.7%
695	Anterior Spinal Artery Syndrome	3.7%
696	Basilar Artery Stenosis	3.7%
697	Vertebral Artery Stenosis	3.7%
698	Sleep Apnea, Obstructive	3.7%
699	Sleep Apnea, Central	3.7%
700	Intracranial Hemorrhage, Hypertensive	3.7%
701	Transient Cerebral Ischemia	3.7%
702	Talipes	3.7%
703	Narcolepsy	3.7%
704	Trigeminal Neuralgia	3.7%
705	Kleine-Levin Syndrome	3.7%
706	Agraphia	3.7%
707	Anomia	3.7%
708	Cluttering	3.7%
709	Language Development Disorders	3.7%
710	Speech Disorders	3.7%
711	Syncope	3.7%
712	Stupor	3.7%
713	Dysgraphia	3.7%
714	Presyncope	3.7%
715	Dyslalia	3.7%
716	Homocystinuria	3.7%
717	Kearns-Sayre syndrome	3.7%
718	Leigh Disease	3.6%
719	Acoustic Neuroma	3.6%
720	Hyperprolactinemia	3.5%
721	Subclavian Steal Syndrome	3.5%
722	Pick Disease of the Brain	3.5%
723	Cataplexy	3.5%
724	Aphasia	3.5%
725	Articulation Disorders	3.5%
726	Echolalia	3.5%
727	Stuttering	3.5%
728	Dysphasia	3.5%
729	Hematoma, Subdural, Intracranial	3.5%
730	Hematoma, Subdural, Chronic	3.5%
731	Hematoma, Subdural, Acute	3.5%
732	Eye Injuries	3.5%
733	Congenital clubfoot	3.5%
734	Vertical Talus	3.5%
735	Paralysis, Obstetric	3.4%
736	Retinopathy of Prematurity	3.4%
737	Autoimmune Lymphoproliferative Syndrome	3.4%
738	Consciousness Disorders	3.4%
739	Mental Retardation	3.4%
740	Muscle Weakness	3.4%
741	Depressed Level of Consciousness	3.4%
742	Mental deficiency	3.4%
743	Intellectual Disability	3.4%
744	Bell Palsy	3.4%
745	Congenital Hyperinsulinism	3.4%
746	Orbital Myositis	3.4%
747	Amino Acid Metabolism, Inborn Errors	3.4%
748	Carbohydrate Metabolism, Inborn Errors	3.4%
749	Catatonia	3.4%
750	Chorioamnionitis	3.4%
751	Metal Metabolism, Inborn Errors	3.4%
752	Progeria	3.4%
753	Lysosomal Storage Diseases	3.4%
754	Cytochrome-c Oxidase Deficiency	3.4%
755	Peroxisomal Disorders	3.4%
756	Dysarthria	3.4%
757	Herpes Zoster Oticus	3.4%
758	Diplopia	3.4%
759	Muscle Rigidity	3.4%
760	Muscle Spasticity	3.4%
761	Scotoma	3.4%
762	Photophobia	3.4%
763	Cogwheel Rigidity	3.4%
764	Hemifacial Spasm	3.4%
765	Amaurosis	3.4%
766	Blindness	3.4%
767	Nuchal Rigidity	3.4%
768	Bronchopulmonary Dysplasia	3.4%
769	Reye Syndrome	3.4%
770	Neuroaspergillosis	3.4%
771	Pyomyositis	3.4%
772	Aphonia	3.4%
773	Angioedemas, Hereditary	3.4%
774	Sleep Deprivation	3.4%
775	Dysphonia	3.4%
776	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.3%
777	Intracranial Embolism and Thrombosis	3.3%
778	Hepatic Encephalopathy	3.3%
779	Wiskott-Aldrich Syndrome	3.3%
780	Agnosia	3.3%
781	Apraxias	3.3%
782	Hallucinations	3.3%
783	Hemianopsia	3.3%
784	Hyperacusis	3.3%
785	Tinnitus	3.3%
786	Visual Agnosia	3.3%
787	Anosognosia	3.3%
788	Wernicke-Korsakoff Syndrome	3.3%
789	Phonophobia	3.3%
790	Hearing Loss	3.3%
791	Sarcopenia	3.3%
792	Sickle Cell Trait	3.3%
793	Gaucher Disease	3.2%
794	Arteriovenous fistula	3.1%
795	Eye Burns	3%
796	Malaria, Cerebral	3%
797	Carotid Stenosis	3%
798	Intracranial Aneurysm	3%
799	Neurocysticercosis	3%
800	Amaurosis Fugax	3%
801	Blindness, Cortical	3%
802	Dyscalculia	3%
803	Intracranial Arteriosclerosis	3%
804	Cerebral Atherosclerosis	3%
805	Subarachnoid Hemorrhage	3%
806	Cerebral Arteriosclerosis	3%
807	Cerebral Hemorrhage	3%
808	Cerebral Thrombosis	3%
809	Intracranial Embolism	3%
810	Intracranial Thrombosis	3%
811	Tay-Sachs Disease	3%
812	Deafness	3%
813	Hearing Loss, Sudden	3%
814	Gerstmann Syndrome	3%
815	Hearing Loss, Bilateral	3%
816	Hearing Loss, High-Frequency	3%
817	Hearing Loss, Mixed Conductive-Sensorineural	3%
818	Prosopagnosia	3%
819	Apraxia, Ideomotor	3%
820	Charles Bonnet Syndrome	3%
821	Hearing Loss, Unilateral	3%
822	Complete Hearing Loss	3%
823	Alien Hand Syndrome	3%
824	Deaf Mutism	3%
825	Pseudorabies	2.9%
826	Myalgia	2.9%
827	Mutism	2.8%
828	Selective Mutism	2.8%
829	Acromegaly	2.8%
830	Amnesia	2.8%
831	Delirium	2.8%
832	Dissociative Amnesia	2.8%
833	Color blindness	2.8%
834	Global Amnesia	2.8%
835	Cerebral Amyloid Angiopathy	2.8%
836	Respiratory Distress Syndrome, Newborn	2.8%
837	Sinus Thrombosis, Intracranial	2.8%
838	Niemann-Pick Disease, Type C	2.8%
839	Meningioma	2.8%
840	Neurosyphilis	2.7%
841	Cutis Laxa	2.7%
842	Retinitis Pigmentosa	2.7%
843	Pigmentary retinopathy	2.7%
844	Alexia, Pure	2.7%
845	Porokeratosis	2.7%
846	Keratoderma, Palmoplantar	2.7%
847	Cavernous Sinus Thrombosis	2.7%
848	Sagittal Sinus Thrombosis	2.7%
849	Chronic granulomatous disease	2.7%
850	Waterhouse-Friderichsen Syndrome	2.6%
851	Dermatomyositis	2.5%
852	Corneal Scar	2.5%
853	Hoarseness	2.5%
854	Acute Chest Syndrome	2.5%
855	Alkaptonuria	2.5%
856	Glycogen Storage Disease	2.5%
857	Hypophosphatasia	2.5%
858	Propionic acidemia	2.5%
859	Dihydropyrimidine Dehydrogenase Deficiency	2.5%
860	Cystinosis	2.5%
861	Alcohol Withdrawal Delirium	2.5%
862	Ophthalmia Neonatorum	2.5%
863	Retrograde amnesia	2.5%
864	Amnesia, Anterograde	2.5%
865	Carotid Artery Thrombosis	2.5%
866	Denys-Drash Syndrome	2.4%
867	Hydrops Fetalis	2.4%
868	Wernicke Encephalopathy	2.4%
869	AIDS Dementia Complex	2.4%
870	Phantom pain	2.3%
871	Phantom Limb Pain	2.3%
872	Lyme Neuroborreliosis	2.3%
873	Corneal Perforation	2.3%
874	Mucopolysaccharidosis III	2.3%
875	Porphyrias, Hepatic	2.3%
876	Nelson Syndrome	2.2%
877	Peutz-Jeghers Syndrome	2.2%
878	Thrombasthenia	2.2%
879	Antithrombin III Deficiency	2.2%
880	Protein C Deficiency	2.2%
881	Afibrinogenemia	2.2%
882	Factor VII Deficiency	2.2%
883	Factor X Deficiency	2.2%
884	Factor XII Deficiency	2.2%
885	Hemophilia A	2.2%
886	Activated Protein C Resistance	2.2%
887	Factor II deficiency	2.2%
888	Factor VIII Deficiency	2.2%
889	Factor V deficiency	2.2%
890	Factor XI Deficiency	2.2%
891	Hypoprothrombinemias	2.2%
892	Fanconi Anemia	2.2%
893	Nesidioblastosis	2.2%
894	Anemia, Diamond-Blackfan	2.2%
895	Hyperphosphaturia	2.2%
896	Glycogen Storage Disease Type I	2.1%
897	Glycogen Storage Disease Type V	2.1%
898	Hyaline Membrane Disease	2%
899	Prolactinoma	2%
900	Growth Hormone-Secreting Pituitary Adenoma	2%
901	Hypolipoproteinemias	2%
902	Papillon-Lefevre Disease	2%
903	Hyperlipidemia, Familial Combined	2%
904	Multiple Endocrine Neoplasia	2%
905	Hyperlipoproteinemia Type III	2%
906	Congenital Hypothyroidism	1.9%
907	Dermatitis, Atopic	1.9%
908	Behcet Syndrome	1.7%
909	Lactose Intolerance	1.7%
910	Variegate Porphyria	1.7%
911	Acute intermittent porphyria	1.7%
912	Porphyria Cutanea Tarda	1.7%
913	Hyperhomocysteinemia	1.7%
914	Renal Aminoacidurias	1.6%
915	Fanconi Syndrome	1.6%
916	Pseudohypoaldosteronism	1.6%
917	Liddle Syndrome	1.6%
918	Hypoalphalipoproteinemias	1.6%
919	Hyperlipoproteinemia Type IV	1.6%
920	Hyperlipoproteinemia Type V	1.6%
921	Gout	1.4%
922	Multiple Endocrine Neoplasia Type 1	1.4%
923	Pseudohypoparathyroidism	1.4%
924	Renal tubular acidosis	1.4%
925	Classical Lissencephalies and Subcortical Band Heterotopias	1.4%
926	Cystinuria	1.4%
927	Nephroblastoma	1.3%
928	Adenomatous Polyposis Coli	1.2%
929	Arthritis, Gouty	1.2%
930	Familial Hypophosphatemic Rickets	1.1%
931	Glycosuria, Renal	1.1%

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