MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Persistent Fetal Circulation Syndrome

(UMLS:C0031190)

Definition:: A syndrome of persistent PULMONARY HYPERTENSION in the newborn infant (INFANT, NEWBORN) without demonstrable HEART DISEASES. This neonatal condition can be caused by severe pulmonary vasoconstriction (reactive type), hypertrophy of pulmonary arterial muscle (hypertrophic type), or abnormally developed pulmonary arterioles (hypoplastic type). The newborn patient exhibits CYANOSIS and ACIDOSIS due to the persistence of fetal circulatory pattern of right-to-left shunting of blood through a patent ductus arteriosus (DUCTUS ARTERIOSUS, PATENT) and at times a patent foramen ovale (FORAMEN OVALE, PATENT).
UMLS ID:: C0031190
MeSH ID:: D010547

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.423.694

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.614.694

Synonym(s)

Persistent Fetal Circulation Syndrome

ALVEOLAR CAPILLARY DYSPLASIA WITH MISALIGNMENT OF PULMONARY VEINS

Newborn persistent pulmonary hypertension

PFC - Persistent fetal circulation

PFC - Persistent foetal circulation

PPHN

PPHN - Persistent pulmonary hypertension in newborn

Persistent Fetal Circulation

Persistent Pulmonary Hypertension of the Newborn

10.

Persistent fetal circulation

11.

Persistent fetal circulation syndrome

12.

Persistent foetal circulation

13.

Persistent foetal circulation syndrome

14.

Persistent pulmonary hypertension of the newborn

15.

circulation; fetal

16.

circulation; fetal persistent

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Indomethacin	7294953 7450523 15008397	CTD
2	Nitric Oxide	11407344	CTD
3	Tolazoline	6646141	CTD
4	carbidopa, levodopa drug combination	6646141	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Cystic Fibrosis	29.4%
2	Respiratory Distress Syndrome, Newborn	29.2%
3	Abdominal Cramps	27.9%
4	Amniotic Band Syndrome	27.9%
5	Asphyxia Neonatorum	27.9%
6	Infant, Premature, Diseases	27.9%
7	Infantile Colic	27.9%
8	Meconium Aspiration Syndrome	24.8%
9	Bronchopulmonary Dysplasia	22.7%
10	Pneumonia	21.1%
11	Lobar Pneumonia	21.1%
12	Respiratory Distress Syndrome, Adult	21.1%
13	Pneumonitis	21.1%
14	Atelectasis	20.9%
15	Pulmonary Alveolar Proteinosis	20.9%
16	Pulmonary Edema	20.9%
17	Pulmonary Fibrosis	20.9%
18	Hamman-Rich syndrome	20.9%
19	Lung Diseases, Interstitial	20.9%
20	Lung Diseases, Obstructive	20.9%
21	Hyaline Membrane Disease	20.8%
22	Anemia, Neonatal	20.7%
23	Umbilical hernia	20.4%
24	Idiopathic Pulmonary Fibrosis	17.6%
25	Xeroderma	17%
26	Mobius Syndrome	17%
27	Lung Diseases, Fungal	16.9%
28	Neonatal Abstinence Syndrome	16.9%
29	Pneumoconiosis	16.9%
30	Bronchitis	16.7%
31	Lung Abscess	16.6%
32	Lung Neoplasms	16.6%
33	Tuberculosis, Pulmonary	16.5%
34	Congenital nystagmus	16.3%
35	Toxoplasmosis, Congenital	16.2%
36	Syphilis, Congenital	16.1%
37	Lung Injury	15.8%
38	Hepatopulmonary Syndrome	15.8%
39	Paralysis, Obstetric	15.5%
40	Retinopathy of Prematurity	15.5%
41	Pulmonary Embolism	15.4%
42	Pulmonary Eosinophilia	15.3%
43	Eosinophilic Pneumonia	15.3%
44	Bronchopneumonia	15.1%
45	Scimitar Syndrome	15%
46	Deformity	14.6%
47	Genetic Diseases, Inborn	14.6%
48	Bronchitis, Chronic	14.4%
49	Acute Chest Syndrome	14.2%
50	Tracheobronchomegaly	14%
51	Asthma	13.7%
52	Chronic Obstructive Airway Disease	13.6%
53	Middle Lobe Syndrome	13.6%
54	Acute Lung Injury	13.6%
55	Congenital Hyperinsulinism	13.6%
56	Aspiration Pneumonia	13.6%
57	Radiation Pneumonitis	13.6%
58	Radiation Fibrosis	13.6%
59	Pleuropneumonia	13.5%
60	Primary Ciliary Dyskinesia	12.6%
61	Hemoptysis	12.3%
62	Bronchial Diseases	12.2%
63	Pleural Diseases	12.2%
64	Respiration Disorders	12.2%
65	Thoracic Diseases	12.2%
66	Tracheal Diseases	12.2%
67	Asbestosis	12.2%
68	Beckwith-Wiedemann Syndrome	12.2%
69	Berylliosis	12.2%
70	Silicosis	12.2%
71	Wolf-Hirschhorn Syndrome	12.2%
72	Ichthyosis, X-Linked	12%
73	Kartagener Syndrome	11.8%
74	Bronchiolitis	11.4%
75	Pneumonia, Viral	11.3%
76	Pneumonia, Bacterial	11%
77	Fetal Diseases	10.9%
78	Multiple Pulmonary Nodules	10.7%
79	Aicardi's syndrome	10.6%
80	Pleurisy	10.5%
81	Tracheitis	10.5%
82	Choanal Atresia	10.5%
83	Laryngocele	10.5%
84	Holoprosencephaly	10.4%
85	Smith-Magenis syndrome	10.2%
86	Histiocytosis, Langerhans-Cell	10.2%
87	Pulmonary Aspergillosis	10.2%
88	Bronchopulmonary Aspergillosis	10.2%
89	Pulmonary Emphysema	10.1%
90	Sarcoidosis, Pulmonary	10.1%
91	Cri-du-Chat Syndrome	10.1%
92	Down Syndrome	10.1%
93	Trisomy 21	10.1%
94	Pulmonary Infarction	10%
95	Leukomalacia, Periventricular	10%
96	Pneumonia, Lipid	10%
97	Sjogren-Larsson Syndrome	10%
98	Hyperkeratosis, Epidermolytic	10%
99	Nesidioblastosis	9.9%
100	Ophthalmia Neonatorum	9.9%
101	CHARGE Syndrome	9.6%
102	Laryngeal Diseases	9.4%
103	Nose Diseases	9.4%
104	Fragile X Syndrome	9.4%
105	Abnormalities, Drug-Induced	9.3%
106	Situs Inversus	9.3%
107	Aspergillosis, Allergic Bronchopulmonary	9.1%
108	Respiratory Tract Infections	9.1%
109	Granuloma, Respiratory Tract	8.9%
110	Respiratory Hypersensitivity	8.9%
111	Respiratory Tract Fistula	8.9%
112	Bronchiolitis Obliterans	8.7%
113	Ectodermal Dysplasia	8.7%
114	Aplasia Cutis Congenita	8.7%
115	Prader-Willi Syndrome	8.6%
116	Rubinstein-Taybi Syndrome	8.5%
117	Laryngitis	8.5%
118	Rhinitis	8.5%
119	Vocal Cord Dysfunction	8.5%
120	Laryngostenosis	8.3%
121	Bronchial Fistula	8.3%
122	Pleural Neoplasms	8.3%
123	Nail-Patella Syndrome	8%
124	Granulomatosis with polyangiitis	8%
125	Granuloma, Laryngeal	7.9%
126	Alstrom Syndrome	7.8%
127	Kernicterus	7.6%
128	Cockayne Syndrome	7.5%
129	Anencephaly	7.4%
130	Farmer's Lung	7.3%
131	Eye Abnormalities	7.3%
132	Neoplastic Syndromes, Hereditary	7.3%
133	Cardiovascular Abnormalities	7.3%
134	Marfan Syndrome	7.2%
135	Skin Abnormalities	7%
136	Lymphatic Abnormalities	7%
137	Congenital Microtia	7%
138	Altitude Sickness	7%
139	Bronchospasm	7%
140	Bronchiectasis	7%
141	Chylothorax	7%
142	Hydropneumothorax	7%
143	Hydrothorax	7%
144	Pneumothorax	7%
145	Respiratory Insufficiency	7%
146	Tracheal Stenosis	7%
147	Bronchial Hyperreactivity	7%
148	Respiratory Depression	7%
149	Respiratory Failure	7%
150	Multiple Epiphyseal Dysplasia	6.9%
151	Osteochondrodysplasias	6.9%
152	Pelger-Huet Anomaly	6.9%
153	Werner Syndrome	6.9%
154	Myasthenic Syndromes, Congenital	6.9%
155	Tracheal Neoplasms	6.9%
156	Sinusitis	6.8%
157	Congenital diaphragmatic hernia	6.8%
158	Familial Mediterranean Fever	6.8%
159	Prune Belly Syndrome	6.8%
160	Twins, Conjoined	6.8%
161	Waardenburg Syndrome	6.8%
162	Bronchial Neoplasms	6.8%
163	Anti-Glomerular Basement Membrane Disease	6.7%
164	Anemia, Sickle Cell	6.7%
165	Thalassemia	6.7%
166	Pleural Effusion, Malignant	6.7%
167	Blastomycosis	6.7%
168	Muscular Dystrophy, Duchenne	6.6%
169	Polycystic Kidney Diseases	6.6%
170	Williams Syndrome	6.6%
171	Rett Syndrome	6.6%
172	Smith-Lemli-Opitz Syndrome	6.6%
173	Classical Lissencephalies and Subcortical Band Heterotopias	6.4%
174	Albinism	6.3%
175	Maxillofacial Abnormalities	6.2%
176	Dural Arteriovenous Fistula	6.2%
177	Mucopolysaccharidosis II	6.2%
178	Dextrocardia	6.1%
179	Transfusion-Related Acute Lung Injury	6.1%
180	Invasive Pulmonary Aspergillosis	6%
181	Laryngeal neoplasm	6%
182	Retinal Dysplasia	5.9%
183	Laryngomalacia	5.9%
184	Aniridia	5.9%
185	Urogenital Abnormalities	5.8%
186	Epidermolysis Bullosa	5.8%
187	Dwarfism	5.7%
188	Fetal Growth Retardation	5.5%
189	Sickle Cell Trait	5.5%
190	Polycystic Kidney, Autosomal Dominant	5.5%
191	Muscular Dystrophy	5.4%
192	Osteogenesis Imperfecta	5.4%
193	Fetal Hypoxia	5.4%
194	Fetal Alcohol Spectrum Disorders	5.4%
195	Menkes Kinky Hair Syndrome	5.4%
196	Laryngospasm	5.4%
197	Asthma, Exercise-Induced	5.4%
198	Status Asthmaticus	5.4%
199	Granuloma, Lethal Midline	5.3%
200	Laryngeal Edema	5.3%
201	Nose Deformities, Acquired	5.3%
202	Respiratory Aspiration	5.3%
203	Microcephaly	5.2%
204	Macrocephaly	5.2%
205	Kallmann Syndrome	5.2%
206	Anophthalmos	5.2%
207	Anus, Imperforate	5.2%
208	Apnea	5.2%
209	Cheyne-Stokes Respiration	5.2%
210	Common Cold	5.2%
211	Dyspnea	5.2%
212	Hemothorax	5.2%
213	Hydranencephaly	5.2%
214	Hyperventilation	5.2%
215	Influenza	5.2%
216	Microphthalmos	5.2%
217	Mouth Breathing	5.2%
218	Neural Tube Defects	5.2%
219	Tethered Cord Syndrome	5.2%
220	Iniencephaly	5.2%
221	Craniorachischisis	5.2%
222	Limb Deformities, Congenital	5.2%
223	Tachypnea	5.2%
224	Exencephaly	5.2%
225	Septo-Optic Dysplasia	5.2%
226	Craniofacial Abnormalities	5.2%
227	Cortical Dysplasia	5.2%
228	Catarrh	5.2%
229	Malformations of Cortical Development	5.2%
230	Anorectal Malformations	5.2%
231	Tuberous Sclerosis	5.1%
232	Severe Acute Respiratory Syndrome	5.1%
233	Laryngopharyngeal Reflux	5.1%
234	Amino Acid Metabolism, Inborn Errors	5.1%
235	Bloom Syndrome	5.1%
236	Carbohydrate Metabolism, Inborn Errors	5.1%
237	Metal Metabolism, Inborn Errors	5.1%
238	Progeria	5.1%
239	Lysosomal Storage Diseases	5.1%
240	Cytochrome-c Oxidase Deficiency	5.1%
241	Peroxisomal Disorders	5.1%
242	Refsum Disease	5%
243	Bronchomalacia	5%
244	Tracheomalacia	5%
245	Wiskott-Aldrich Syndrome	5%
246	Turner Syndrome	5%
247	Neuronal Ceroid-Lipofuscinoses	5%
248	Porencephaly	4.9%
249	Klinefelter Syndrome	4.9%
250	Acrocephalosyndactylia	4.8%
251	Craniosynostosis	4.7%
252	Syndactyly	4.7%
253	Brachycephaly	4.7%
254	Charcot-Marie-Tooth Disease	4.7%
255	Antley-Bixler Syndrome Phenotype	4.7%
256	Asthma, Occupational	4.6%
257	Autoimmune Lymphoproliferative Syndrome	4.6%
258	Nose Neoplasms	4.6%
259	Airway Obstruction	4.5%
260	Choking	4.5%
261	Epiglottitis	4.5%
262	Mediastinitis	4.5%
263	Chorioamnionitis	4.5%
264	Rhinoscleroma	4.5%
265	Pseudoxanthoma Elasticum	4.5%
266	Angioedemas, Hereditary	4.5%
267	Paranasal Sinus Neoplasms	4.5%
268	Myotonic Dystrophy	4.4%
269	Adrenoleukodystrophy	4.4%
270	Zellweger Syndrome	4.4%
271	Glycogen storage disease type II	4.4%
272	Eosinophilic Granuloma	4.3%
273	Fabry Disease	4.3%
274	Pharyngitis	4.2%
275	Hoarseness	4.2%
276	Amelia	4.2%
277	Arachnodactyly	4.2%
278	Ectopia Cordis	4.2%
279	Ectromelia	4.2%
280	Hemimelia	4.2%
281	Meningomyelocele	4.2%
282	Noonan Syndrome	4.2%
283	Phocomelia	4.2%
284	Sirenomelia	4.2%
285	Spina Bifida	4.2%
286	Polydactyly	4.2%
287	Brachydactyly	4.2%
288	Plagiocephaly	4.2%
289	Lower Extremity Deformities, Congenital	4.2%
290	Upper Extremity Deformities, Congenital	4.2%
291	Single umbilical artery	4.2%
292	Poland Syndrome	4.2%
293	Mucopolysaccharidosis III	4.2%
294	Alkaptonuria	4.2%
295	Blepharophimosis	4.2%
296	Glycogen Storage Disease	4.2%
297	Hypophosphatasia	4.2%
298	Mouth Abnormalities	4.2%
299	Nasal Polyps	4.2%
300	Propionic acidemia	4.2%
301	Dihydropyrimidine Dehydrogenase Deficiency	4.2%
302	Cystinosis	4.2%
303	Cutis Laxa	4.1%
304	Esophageal Atresia	4.1%
305	Intestinal Atresia	4.1%
306	Horseshoe Kidney	4.1%
307	Pectus excavatum	4.1%
308	Cleft Palate	4.1%
309	Galactosemias	4.1%
310	Urea Cycle Disorders, Inborn	4.1%
311	Tyrosinemias	4.1%
312	Klippel-Feil Syndrome	4.1%
313	Retinitis Pigmentosa	4.1%
314	Pertussis	4.1%
315	Gastroschisis	4.1%
316	Synostosis	4.1%
317	Pigmentary retinopathy	4.1%
318	Hepatolenticular Degeneration	4.1%
319	Acrodermatitis	4.1%
320	Lymphangiectasis, Intestinal	4.1%
321	Xeroderma Pigmentosum	4.1%
322	Porokeratosis	4.1%
323	Gianotti-Crosti Syndrome	4.1%
324	Keratoderma, Palmoplantar	4.1%
325	Chronic granulomatous disease	4%
326	Amyloid Neuropathies, Familial	4%
327	Jaw Abnormalities	4%
328	Welander Distal Myopathy	4%
329	Hydrops Fetalis	3.9%
330	Hay fever	3.9%
331	Rhinitis, Allergic, Perennial	3.9%
332	Asthma, Aspirin-Induced	3.8%
333	Abnormalities, Radiation-Induced	3.8%
334	Dermal Sinus	3.7%
335	Spina Bifida Cystica	3.7%
336	Spina Bifida Occulta	3.7%
337	Lissencephaly	3.7%
338	Polymicrogyria	3.7%
339	Pachygyria	3.7%
340	Schizencephaly	3.7%
341	Periventricular Nodular Heterotopia	3.7%
342	Glycogen Storage Disease Type I	3.7%
343	Glycogen Storage Disease Type V	3.7%
344	Gaucher Disease	3.7%
345	Optic Atrophy, Hereditary, Leber	3.7%
346	Hyperphosphaturia	3.6%
347	Basal Cell Nevus Syndrome	3.6%
348	Micrognathism	3.6%
349	Pierre Robin Syndrome	3.6%
350	Tay-Sachs Disease	3.5%
351	Arthrogryposis	3.5%
352	Voice Disorders	3.5%
353	Voice Disturbance	3.5%
354	Homocystinuria	3.5%
355	Choledochal Cyst	3.4%
356	Duane Retraction Syndrome	3.4%
357	Epistaxis	3.4%
358	Hermaphroditism	3.4%
359	Leigh Disease	3.4%
360	Mediastinal Cyst	3.4%
361	Pericardial Cyst	3.4%
362	Disorders of Sex Development	3.4%
363	Thymic Cyst	3.4%
364	Canavan Disease	3.4%
365	Alexander Disease	3.4%
366	Cryptorchidism	3.4%
367	Porphyrias, Hepatic	3.4%
368	Hypospadias	3.4%
369	Croup	3.4%
370	Mediastinal Emphysema	3.4%
371	Rhinitis, Vasomotor	3.4%
372	Central Nervous System Cysts	3.4%
373	Hypoventilation	3.4%
374	Dandy-Walker Syndrome	3.4%
375	Acidosis, Respiratory	3.4%
376	Alkalosis, Respiratory	3.4%
377	Sleep Apnea Syndromes	3.4%
378	Peutz-Jeghers Syndrome	3.4%
379	Aortic coarctation	3.4%
380	Cor Triatriatum	3.4%
381	Coronary Vessel Anomalies	3.4%
382	Dental Enamel Hypoplasia	3.4%
383	Patent ductus arteriosus	3.4%
384	Ebstein Anomaly	3.4%
385	Heart Septal Defects	3.4%
386	Hypodontia	3.4%
387	Macrostomia	3.4%
388	Meningocele	3.4%
389	Microstomia	3.4%
390	Tetralogy of Fallot	3.4%
391	Transposition of Great Vessels	3.4%
392	Hypoplastic Left Heart Syndrome	3.4%
393	May-Thurner Syndrome	3.4%
394	Encephalocele	3.4%
395	Myotonia Congenita	3.4%
396	Thrombasthenia	3.4%
397	Antithrombin III Deficiency	3.4%
398	Protein C Deficiency	3.4%
399	Brain Diseases, Metabolic, Inborn	3.4%
400	Afibrinogenemia	3.3%
401	Craniofacial Dysostosis	3.3%
402	Dystonia Musculorum Deformans	3.3%
403	Factor VII Deficiency	3.3%
404	Factor X Deficiency	3.3%
405	Factor XII Deficiency	3.3%
406	Hemophilia A	3.3%
407	POEMS Syndrome	3.3%
408	Activated Protein C Resistance	3.3%
409	Factor II deficiency	3.3%
410	Factor VIII Deficiency	3.3%
411	Factor V deficiency	3.3%
412	Factor XI Deficiency	3.3%
413	Hypoprothrombinemias	3.3%
414	Fanconi Anemia	3.3%
415	Hypolipoproteinemias	3.3%
416	Papillon-Lefevre Disease	3.3%
417	Wolff-Parkinson-White Syndrome	3.3%
418	Lafora Disease	3.3%
419	Unverricht-Lundborg Syndrome	3.3%
420	Hyperlipidemia, Familial Combined	3.3%
421	Anemia, Diamond-Blackfan	3.3%
422	Hyperlipoproteinemia Type III	3.3%
423	Niemann-Pick Disease, Type C	3.3%
424	Maxillary Sinus Neoplasms	3.3%
425	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.2%
426	Retrognathia	3.2%
427	Ataxia Telangiectasia	3%
428	Aortopulmonary Septal Defect	3%
429	Double Outlet Right Ventricle	3%
430	Endocardial Cushion Defects	3%
431	Multiple Endocrine Neoplasia	3%
432	Myocardial bridging	3%
433	Aorticopulmonary Septal Defect	3%
434	Hypoalphalipoproteinemias	3%
435	Pectus carinatum	2.9%
436	Vocal Cord Paralysis	2.9%
437	Hyperandrogenism	2.9%
438	Bladder Exstrophy	2.9%
439	Congenital Hypothyroidism	2.9%
440	Epispadias	2.9%
441	Dermatitis, Atopic	2.9%
442	Prognathism	2.9%
443	Multicystic Dysplastic Kidney	2.9%
444	Familial Periodic Paralysis	2.8%
445	Long QT Syndrome	2.8%
446	Platybasia	2.8%
447	Tricuspid Atresia	2.8%
448	Arrhythmogenic Right Ventricular Dysplasia	2.8%
449	Truncus Arteriosus, Persistent	2.8%
450	Gonadal Dysgenesis	2.8%
451	Goldenhar Syndrome	2.8%
452	Adrenogenital Syndrome	2.8%
453	Ovotesticular Disorders of Sex Development	2.8%
454	Lactose Intolerance	2.8%
455	Variegate Porphyria	2.8%
456	Acute intermittent porphyria	2.8%
457	Porphyria Cutanea Tarda	2.8%
458	Hyperhomocysteinemia	2.8%
459	Renal Aminoacidurias	2.7%
460	Fanconi Syndrome	2.7%
461	Pseudohypoaldosteronism	2.7%
462	Liddle Syndrome	2.7%
463	Hyperlipoproteinemia Type IV	2.7%
464	Hyperlipoproteinemia Type V	2.7%
465	Tonsillitis	2.7%
466	Dyspnea, Paroxysmal	2.7%
467	Respiratory Paralysis	2.7%
468	Behcet Syndrome	2.5%
469	Sleep Apnea, Obstructive	2.5%
470	Sleep Apnea, Central	2.5%
471	Hypokalemic periodic paralysis	2.5%
472	Mandibulofacial Dysostosis	2.5%
473	Romano-Ward Syndrome	2.5%
474	Cystinuria	2.4%
475	Gout	2.4%
476	Multiple Endocrine Neoplasia Type 1	2.4%
477	Pseudohypoparathyroidism	2.4%
478	Friedreich Ataxia	2.4%
479	Talipes	2.3%
480	Renal tubular acidosis	2.3%
481	Congenital clubfoot	2.2%
482	Vertical Talus	2.2%
483	Aphonia	2.2%
484	Retropharyngeal Abscess	2.2%
485	Dysphonia	2.2%
486	Huntington Disease	2.2%
487	Denys-Drash Syndrome	2.2%
488	Arthritis, Gouty	2.1%
489	Familial Hypophosphatemic Rickets	2.1%
490	Nephroblastoma	2%
491	Nasopharyngitis	1.9%
492	Arteriovenous fistula	1.9%
493	Glycosuria, Renal	1.8%
494	Adenomatous Polyposis Coli	1.8%
495	Peritonsillar Abscess	1.6%
496	MELAS Syndrome	1.5%

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