MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Progeria

(UMLS:C0033300)

Definition:: An abnormal congenital condition, associated with defects in the LAMIN TYPE A gene, which is characterized by premature aging in children, where all the changes of cell senescence occur. It is manifested by premature greying; hair loss; hearing loss (DEAFNESS); cataracts (CATARACT); ARTHRITIS; OSTEOPOROSIS; DIABETES MELLITUS; atrophy of subcutaneous fat; skeletal hypoplasia; elevated urinary HYALURONIC ACID; and accelerated ATHEROSCLEROSIS. Many affected individuals develop malignant tumors, especially SARCOMA.
UMLS ID:: C0033300
MeSH ID:: D011371

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.753

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.648.753

Synonym(s)

Progeria

Gilford's syndrome

Gilford-Hutchinson

HUTCHINSON-GILFORD PROGERIA SYNDROME

Hutchinson-Gilford

Hutchinson-Gilford Disease

Hutchinson-Gilford Progeria Syndrome

Hutchinson-Gilford syndrome

Premature Senility Syndrome

10.

Premature senility syndrome

11.

Progeria syndrome

12.

Senilism syndrome

13.

hutchinson gilford syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Oxcarbazepine	FAERS: 1		US FAERS
2	Penicillamine	FAERS: 1		US FAERS
3	Resveratrol		23217256	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Amino Acid Metabolism, Inborn Errors	46.7%
2	Carbohydrate Metabolism, Inborn Errors	46.7%
3	Metal Metabolism, Inborn Errors	46.7%
4	Lysosomal Storage Diseases	46.7%
5	Peroxisomal Disorders	46.7%
6	Smith-Lemli-Opitz Syndrome	39.6%
7	Galactosemias	37.7%
8	Urea Cycle Disorders, Inborn	37.7%
9	Tyrosinemias	37.7%
10	Brain Diseases, Metabolic, Inborn	37.6%
11	Glycogen storage disease type II	36%
12	Leigh Disease	35.3%
13	Alkaptonuria	34.4%
14	Glycogen Storage Disease	34.4%
15	Hypophosphatasia	34.4%
16	Propionic acidemia	34.4%
17	Dihydropyrimidine Dehydrogenase Deficiency	34.4%
18	Cystinosis	34.4%
19	Hyperphosphaturia	33.5%
20	Hypolipoproteinemias	33.3%
21	Cytochrome-c Oxidase Deficiency	33.3%
22	Mucopolysaccharidosis III	32.3%
23	Hyperlipidemia, Familial Combined	32.2%
24	Carbamoyl-Phosphate Synthase I Deficiency Disease	32.1%
25	Hyperlipoproteinemia Type III	31.7%
26	Gaucher Disease	31.5%
27	Homocystinuria	31.2%
28	Pseudohypoparathyroidism	31.1%
29	Hyperhomocysteinemia	30.6%
30	Menkes Kinky Hair Syndrome	30%
31	Hyperlipoproteinemia Type IV	29.9%
32	Hyperlipoproteinemia Type V	29.9%
33	Lactose Intolerance	29.5%
34	Tay-Sachs Disease	28.6%
35	Glycogen Storage Disease Type I	28.5%
36	Glycogen Storage Disease Type V	28.5%
37	Mucopolysaccharidosis II	28.3%
38	Fabry Disease	27.6%
39	Adrenoleukodystrophy	27.5%
40	Hypoalphalipoproteinemias	27.5%
41	Niemann-Pick Disease, Type C	27.1%
42	Hepatolenticular Degeneration	26.5%
43	Zellweger Syndrome	26.5%
44	Refsum Disease	26.2%
45	Neuronal Ceroid-Lipofuscinoses	26.2%
46	Werner Syndrome	25.4%
47	Amyloid Neuropathies, Familial	25%
48	Albinism	24.4%
49	Renal tubular acidosis	23.7%
50	Familial Periodic Paralysis	23.3%
51	Familial Hypophosphatemic Rickets	23.3%
52	Renal Aminoacidurias	22.8%
53	Fanconi Syndrome	22.8%
54	Pseudohypoaldosteronism	22.8%
55	Liddle Syndrome	22.8%
56	Ichthyosis, X-Linked	21.8%
57	Antley-Bixler Syndrome Phenotype	21%
58	Wasting Syndrome	20.7%
59	Acid-Base Imbalance	20.5%
60	Calcium Metabolism Disorders	20.5%
61	Iron Metabolism Disorders	20.5%
62	Phosphorus Metabolism Disorders	20.5%
63	Water-Electrolyte Imbalance	20.5%
64	Lipid Metabolism Disorders	20.5%
65	Mitochondrial Diseases	20.5%
66	Glucose Metabolism Disorders	20.5%
67	Gout	20%
68	Hypercalcemia	20%
69	Hypocalcemia	20%
70	Milk-Alkali Syndrome	20%
71	Hypokalemic periodic paralysis	19%
72	Cystinuria	18.8%
73	Sjogren-Larsson Syndrome	18.7%
74	Glycosuria, Renal	18.3%
75	Canavan Disease	17.7%
76	Alexander Disease	17.7%
77	MELAS Syndrome	17.2%
78	Cockayne Syndrome	16.6%
79	Arthritis, Gouty	16.3%
80	Neoplastic Syndromes, Hereditary	16.1%
81	Lipodystrophy	16%
82	Osteopenia	15.5%
83	Brain Diseases, Metabolic	15.3%
84	Multiple Epiphyseal Dysplasia	15.3%
85	Osteochondrodysplasias	15.3%
86	Pelger-Huet Anomaly	15.3%
87	Myasthenic Syndromes, Congenital	15.3%
88	CHARGE Syndrome	14.9%
89	Rickets	14.4%
90	Cystic Fibrosis	14%
91	Aicardi's syndrome	13.9%
92	Fragile X Syndrome	13.9%
93	Porphyrias, Hepatic	13.5%
94	Congenital Hyperinsulinism	13.5%
95	Acidosis	13.3%
96	Alkalosis	13.3%
97	Amyloidosis	13.3%
98	Beckwith-Wiedemann Syndrome	13.3%
99	Bloom Syndrome	13.3%
100	Calcinosis	13.3%
101	Hyperglycemia	13.3%
102	Hyperinsulinism	13.3%
103	Hyperkalemia	13.3%
104	Hypernatremia	13.3%
105	Hypoglycemia	13.3%
106	Hypokalemia	13.3%
107	Hyponatremia	13.3%
108	Familial Mediterranean Fever	13.3%
109	Xanthomatosis	13.3%
110	Hypophosphatemia	13.3%
111	Metabolic acidosis	13.3%
112	Dyslipidemias	13.3%
113	Iron Overload	13.3%
114	Xanthoma	13.3%
115	Wolf-Hirschhorn Syndrome	13.3%
116	Anemia, Sickle Cell	13.2%
117	Thalassemia	13.2%
118	Muscular Dystrophy, Duchenne	13.2%
119	Fanconi Anemia	13.1%
120	Dwarfism	12.7%
121	Nail-Patella Syndrome	12.5%
122	Muscular Dystrophy	12.1%
123	Osteogenesis Imperfecta	12.1%
124	Deformity	11.9%
125	Nutrition Disorders	11.9%
126	Rett Syndrome	11.7%
127	Smith-Magenis syndrome	11.2%
128	Ataxia Telangiectasia	11.2%
129	Cri-du-Chat Syndrome	11%
130	Down Syndrome	11%
131	Trisomy 21	11%
132	Optic Atrophy, Hereditary, Leber	10.9%
133	Osteomalacia	10.9%
134	Prader-Willi Syndrome	10.8%
135	Diabetic Ketoacidosis	10.8%
136	Alstrom Syndrome	10.7%
137	Diabetes Mellitus	10.5%
138	Nesidioblastosis	10.4%
139	Autoimmune Lymphoproliferative Syndrome	10.2%
140	Dehydration	10.2%
141	Lipomatosis	10.2%
142	Water Intoxication	10.2%
143	Achlorhydria	10%
144	Osteoporosis	10%
145	Bone Demineralization, Pathologic	10%
146	Post-Traumatic Osteoporosis	10%
147	Angioedemas, Hereditary	9.9%
148	Celiac Disease	9.9%
149	Sprue, Tropical	9.9%
150	Steatorrhea	9.9%
151	Sprue	9.9%
152	Wiskott-Aldrich Syndrome	9.9%
153	Acidosis, Lactic	9.9%
154	Calciphylaxis	9.9%
155	Hemosiderosis	9.9%
156	Ketosis	9.9%
157	Ketonuria	9.9%
158	Ketoacidosis	9.9%
159	Ketonemia	9.9%
160	Vascular calcification	9.9%
161	Mitochondrial Encephalomyopathies	9.9%
162	Variegate Porphyria	9.8%
163	Acute intermittent porphyria	9.8%
164	Porphyria Cutanea Tarda	9.8%
165	Friedreich Ataxia	9.8%
166	Sickle Cell Trait	9.7%
167	Holoprosencephaly	9.6%
168	Ectodermal Dysplasia	9.5%
169	Aplasia Cutis Congenita	9.5%
170	Xeroderma Pigmentosum	9.4%
171	Marfan Syndrome	9.4%
172	Kartagener Syndrome	9.3%
173	Fetal Diseases	8.9%
174	Primary Ciliary Dyskinesia	8.9%
175	Myotonic Dystrophy	8.8%
176	Polycystic Kidney Diseases	8.8%
177	Williams Syndrome	8.8%
178	Kallmann Syndrome	8.4%
179	Rubinstein-Taybi Syndrome	8.4%
180	Hypercholesterolemia	8.2%
181	Hyperlipoproteinemias	8.2%
182	Hypertriglyceridemia	8.2%
183	Tuberous Sclerosis	8.2%
184	Cutis Laxa	8.1%
185	Mitochondrial Myopathies	8.1%
186	Retinitis Pigmentosa	8.1%
187	Myelinolysis, Central Pontine	8.1%
188	Pigmentary retinopathy	8.1%
189	Porokeratosis	8%
190	Keratoderma, Palmoplantar	8%
191	Glycosuria	7.9%
192	Chronic granulomatous disease	7.9%
193	Reye Syndrome	7.9%
194	Hepatic Encephalopathy	7.9%
195	Welander Distal Myopathy	7.9%
196	Retinal Dysplasia	7.8%
197	Aniridia	7.8%
198	Epidermolysis Bullosa	7.6%
199	HIV Wasting Syndrome	7.5%
200	Acute Chest Syndrome	7.5%
201	Acidosis, Respiratory	7.4%
202	Adiposis Dolorosa	7.4%
203	Alkalosis, Respiratory	7.4%
204	Insulin Resistance	7.4%
205	Osteoporosis, Postmenopausal	7.4%
206	HIV-Associated Lipodystrophy Syndrome	7.3%
207	Renal Osteodystrophy	7.3%
208	Renal rickets	7.3%
209	Abdominal Cramps	6.8%
210	Abnormalities, Drug-Induced	6.8%
211	Amniotic Band Syndrome	6.8%
212	Asphyxia Neonatorum	6.8%
213	Child Nutrition Disorders	6.8%
214	Duane Retraction Syndrome	6.8%
215	Hypervitaminosis A	6.8%
216	Infant Nutrition Disorders	6.8%
217	Infant, Premature, Diseases	6.8%
218	Situs Inversus	6.8%
219	Malnutrition	6.8%
220	Infantile Colic	6.8%
221	Kernicterus	6.7%
222	Peutz-Jeghers Syndrome	6.6%
223	Wernicke Encephalopathy	6.6%
224	Myotonia Congenita	6.6%
225	Thrombasthenia	6.6%
226	Antithrombin III Deficiency	6.6%
227	Necrobiosis Lipoidica Diabeticorum	6.6%
228	Protein C Deficiency	6.6%
229	Afibrinogenemia	6.6%
230	Dystonia Musculorum Deformans	6.6%
231	Factor VII Deficiency	6.6%
232	Factor X Deficiency	6.6%
233	Factor XII Deficiency	6.6%
234	Hemophilia A	6.6%
235	Activated Protein C Resistance	6.6%
236	Factor II deficiency	6.6%
237	Factor VIII Deficiency	6.6%
238	Factor V deficiency	6.6%
239	Factor XI Deficiency	6.6%
240	Hypoprothrombinemias	6.6%
241	Lafora Disease	6.5%
242	Unverricht-Lundborg Syndrome	6.5%
243	Anemia, Diamond-Blackfan	6.5%
244	Polycystic Kidney, Autosomal Dominant	6.5%
245	Classical Lissencephalies and Subcortical Band Heterotopias	6.3%
246	Gestational Diabetes	6.1%
247	Latent Autoimmune Diabetes in Adults	6.1%
248	Diabetes Mellitus, Experimental	6%
249	Pseudoxanthoma Elasticum	5.9%
250	Nephrocalcinosis	5.9%
251	Tetany	5.9%
252	Meconium Aspiration Syndrome	5.9%
253	Multiple Endocrine Neoplasia	5.9%
254	Papillon-Lefevre Disease	5.9%
255	Hyperkeratosis, Epidermolytic	5.9%
256	Cerebral Amyloid Angiopathy	5.8%
257	Congenital Hypothyroidism	5.7%
258	Dermatitis, Atopic	5.7%
259	Xeroderma	5.6%
260	Mobius Syndrome	5.6%
261	Charcot-Marie-Tooth Disease	5.6%
262	Eye Abnormalities	5.4%
263	Cardiovascular Abnormalities	5.4%
264	Kearns-Sayre syndrome	5.3%
265	Skin Abnormalities	5.2%
266	Lymphatic Abnormalities	5.2%
267	Congenital Microtia	5.2%
268	Anemia, Neonatal	5.1%
269	Persistent Fetal Circulation Syndrome	5.1%
270	Congenital diaphragmatic hernia	5%
271	Umbilical hernia	5%
272	Behcet Syndrome	5%
273	Primary amyloidosis	5%
274	Basal Cell Nevus Syndrome	4.8%
275	Anencephaly	4.6%
276	Klinefelter Syndrome	4.5%
277	Deficiency Diseases	4.4%
278	Prune Belly Syndrome	4.4%
279	Starvation	4.4%
280	Twins, Conjoined	4.4%
281	Refeeding Syndrome	4.4%
282	Waardenburg Syndrome	4.4%
283	Huntington Disease	4.4%
284	Urogenital Abnormalities	4.3%
285	Amyotrophic Lateral Sclerosis	4.3%
286	Multiple Endocrine Neoplasia Type 1	4.2%
287	Hydrops Fetalis	4.2%
288	Neonatal Abstinence Syndrome	4.2%
289	Fetal Growth Retardation	4.1%
290	Frontotemporal dementia	4.1%
291	Fetal Hypoxia	4%
292	Congenital nystagmus	4%
293	Fetal Alcohol Spectrum Disorders	4%
294	Toxoplasmosis, Congenital	4%
295	Syphilis, Congenital	4%
296	Nephroblastoma	3.9%
297	Maxillofacial Abnormalities	3.9%
298	Dural Arteriovenous Fistula	3.9%
299	Turner Syndrome	3.9%
300	Dextrocardia	3.9%
301	CREST Syndrome	3.7%
302	Adenomatous Polyposis Coli	3.5%
303	Anophthalmos	3.4%
304	Anus, Imperforate	3.4%
305	Hydranencephaly	3.4%
306	Microphthalmos	3.4%
307	Neural Tube Defects	3.4%
308	Paralysis, Obstetric	3.4%
309	Retinopathy of Prematurity	3.4%
310	Tethered Cord Syndrome	3.4%
311	Iniencephaly	3.4%
312	Craniorachischisis	3.4%
313	Limb Deformities, Congenital	3.4%
314	Exencephaly	3.4%
315	Septo-Optic Dysplasia	3.4%
316	Craniofacial Abnormalities	3.4%
317	Cortical Dysplasia	3.4%
318	Malformations of Cortical Development	3.4%
319	Anorectal Malformations	3.4%
320	Chorioamnionitis	3.4%
321	Bronchopulmonary Dysplasia	3.3%
322	Kwashiorkor	3.3%
323	Magnesium Deficiency	3.3%
324	Potassium Deficiency	3.3%
325	Protein Deficiency	3.3%
326	Avitaminosis	3.3%
327	Microcephaly	3%
328	Macrocephaly	3%
329	Scimitar Syndrome	3%
330	Abnormalities, Radiation-Induced	2.9%
331	Craniosynostosis	2.8%
332	Syndactyly	2.8%
333	Brachycephaly	2.8%
334	Blepharophimosis	2.7%
335	Laryngostenosis	2.7%
336	Mouth Abnormalities	2.7%
337	Respiratory Distress Syndrome, Newborn	2.7%
338	Ascorbic Acid Deficiency	2.7%
339	Vitamin A Deficiency	2.7%
340	Vitamin D Deficiency	2.7%
341	Vitamin E Deficiency	2.7%
342	Marasmus	2.7%
343	Esophageal Atresia	2.7%
344	Intestinal Atresia	2.7%
345	Horseshoe Kidney	2.7%
346	Pectus excavatum	2.7%
347	Porencephaly	2.7%
348	Klippel-Feil Syndrome	2.7%
349	Gastroschisis	2.7%
350	Synostosis	2.7%
351	Acrocephalosyndactylia	2.7%
352	Acrodermatitis	2.7%
353	Lymphangiectasis, Intestinal	2.7%
354	Gianotti-Crosti Syndrome	2.7%
355	Denys-Drash Syndrome	2.6%
356	Noonan Syndrome	2.5%
357	Amelia	2.5%
358	Arachnodactyly	2.5%
359	Ectopia Cordis	2.5%
360	Ectromelia	2.5%
361	Hemimelia	2.5%
362	Meningomyelocele	2.5%
363	Phocomelia	2.5%
364	Sirenomelia	2.5%
365	Spina Bifida	2.5%
366	Polydactyly	2.5%
367	Brachydactyly	2.5%
368	Plagiocephaly	2.5%
369	Lower Extremity Deformities, Congenital	2.5%
370	Upper Extremity Deformities, Congenital	2.5%
371	Single umbilical artery	2.5%
372	Ophthalmia Neonatorum	2.5%
373	Folic Acid Deficiency	2.5%
374	Pellagra	2.5%
375	Thiamine Deficiency	2.5%
376	Vitamin B 12 Deficiency	2.5%
377	Vitamin B 6 Deficiency	2.5%
378	Pyridoxine Deficiency	2.5%
379	Beriberi	2.3%
380	Poland Syndrome	2.3%
381	Cleft Palate	2.3%
382	Arthrogryposis	2.3%
383	Choanal Atresia	2.3%
384	Tracheobronchomegaly	2.3%
385	Laryngocele	2.3%
386	Jaw Abnormalities	2.3%
387	Choledochal Cyst	2.3%
388	Hermaphroditism	2.3%
389	Disorders of Sex Development	2.3%
390	Cryptorchidism	2.2%
391	Hypospadias	2.2%
392	Central Nervous System Cysts	2.2%
393	Dandy-Walker Syndrome	2.2%
394	Leukomalacia, Periventricular	2.2%
395	POEMS Syndrome	2.2%
396	Obesity	2.2%
397	Dermal Sinus	2%
398	Spina Bifida Cystica	2%
399	Spina Bifida Occulta	2%
400	Lissencephaly	2%
401	Polymicrogyria	2%
402	Pachygyria	2%
403	Schizencephaly	2%
404	Periventricular Nodular Heterotopia	2%
405	Aortic coarctation	2%
406	Cor Triatriatum	2%
407	Coronary Vessel Anomalies	2%
408	Dental Enamel Hypoplasia	2%
409	Patent ductus arteriosus	2%
410	Ebstein Anomaly	2%
411	Heart Septal Defects	2%
412	Hyaline Membrane Disease	2%
413	Hypodontia	2%
414	Macrostomia	2%
415	Meningocele	2%
416	Microstomia	2%
417	Tetralogy of Fallot	2%
418	Transposition of Great Vessels	2%
419	Hypoplastic Left Heart Syndrome	2%
420	May-Thurner Syndrome	2%
421	Encephalocele	2%
422	Craniofacial Dysostosis	2%
423	Wolff-Parkinson-White Syndrome	2%
424	Laryngomalacia	2%
425	Pectus carinatum	1.9%
426	Obesity, Abdominal	1.9%
427	Micrognathism	1.9%
428	Pierre Robin Syndrome	1.9%
429	Bladder Exstrophy	1.9%
430	Epispadias	1.9%
431	Multicystic Dysplastic Kidney	1.9%
432	Retrognathia	1.7%
433	Anemia, Pernicious	1.7%
434	Long QT Syndrome	1.7%
435	Platybasia	1.7%
436	Tricuspid Atresia	1.7%
437	Arrhythmogenic Right Ventricular Dysplasia	1.7%
438	Vitamin K Deficiency	1.7%
439	Gonadal Dysgenesis	1.6%
440	Bronchomalacia	1.6%
441	Adrenogenital Syndrome	1.6%
442	Tracheomalacia	1.6%
443	Ovotesticular Disorders of Sex Development	1.6%
444	Aortopulmonary Septal Defect	1.6%
445	Double Outlet Right Ventricle	1.6%
446	Endocardial Cushion Defects	1.6%
447	Myocardial bridging	1.6%
448	Aorticopulmonary Septal Defect	1.6%
449	Hyperandrogenism	1.6%
450	Pediatric Obesity	1.6%
451	Prognathism	1.6%
452	Scurvy	1.5%
453	Truncus Arteriosus, Persistent	1.5%
454	Goldenhar Syndrome	1.5%
455	Mandibulofacial Dysostosis	1.4%
456	Romano-Ward Syndrome	1.4%
457	Talipes	1.2%
458	Congenital clubfoot	1.1%
459	Vertical Talus	1.1%
460	Arteriovenous fistula	1%
461	Subacute Combined Degeneration	1%

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