MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Juvenile Myoclonic Epilepsy

(UMLS:C0270853)

Definition:: A disorder characterized by the onset of myoclonus in adolescence, a marked increase in the incidence of absence seizures (see EPILEPSY, ABSENCE), and generalized major motor seizures (see EPILEPSY, TONIC-CLONIC). The myoclonic episodes tend to occur shortly after awakening. Seizures tend to be aggravated by sleep deprivation and alcohol consumption. Hereditary and sporadic forms have been identified. (From Adams et al., Principles of Neurology, 6th ed, p323)
UMLS ID:: C0270853
MeSH ID:: D020190

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.490.375.130.670|C10.228.140.490.493.063.670

Synonym(s)

Juvenile Myoclonic Epilepsy

EPILEPSY, MYOCLONIC JUVENILE

Impulsive petit mal of Janz

Impulsive petit-mal epilepsy

JME - Juvenile myoclonic epilepsy

Janz syndrome

Juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy of Janz

Myoclonic epilepsy of adolescence

10.

epilepsy juvenile myoclonic

11.

generalized convulsive myoclonic seizure, juvenile

12.

impulsive; petit mal

13.

janz syndrome

14.

juvenile myoclonic epilepsy

15.

myoclonic; epileptic, juvenile

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Levetiracetam	FAERS: 4	US FAERS
2	Valproic Acid	FAERS: 3	US FAERS
3	Lacosamide	FAERS: 1	US FAERS
4	Omeprazole	FAERS: 1	US FAERS
5	Pregabalin	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Myoclonic Epilepsies, Progressive	61.4%
2	Epilepsy, Temporal Lobe	45.1%
3	Epilepsy, Rolandic	45.1%
4	Benign Rolandic Epilepsy	45.1%
5	Epilepsies, Partial	39.7%
6	Simple Partial Seizures	39.7%
7	Epilepsy, Reflex	39.7%
8	Akinetic Mutism	33.7%
9	Anoxic Encephalopathy	33.7%
10	Basal Ganglia Diseases	33.7%
11	Brain Damage, Chronic	33.7%
12	Cerebellar Diseases	33.7%
13	Encephalitis	33.7%
14	Encephalomalacia	33.7%
15	Hydrocephalus	33.7%
16	Congenital Hydrocephalus	33.7%
17	Hypothalamic Diseases	33.7%
18	Thalamic Diseases	33.7%
19	Intracranial Hypertension	33.7%
20	Leukoencephalopathy	33.7%
21	Neuroaxonal Dystrophies	33.7%
22	Headache Disorders	33.7%
23	Intracranial Hypotension	33.7%
24	Brain Edema	33.7%
25	Brain Hypoxia	33.7%
26	Aqueductal Stenosis	33.7%
27	Lafora Disease	33.6%
28	Unverricht-Lundborg Syndrome	33.6%
29	Encephalomyelitis	32.1%
30	Subdural Effusion	31.3%
31	Epilepsy, Post-Traumatic	30.7%
32	Meningoencephalitis	28%
33	Meningitis	27.9%
34	Movement Disorders	27.9%
35	Pachymeningitis	27.9%
36	Spinal Cord Diseases	27.9%
37	Brain Diseases, Metabolic	25.9%
38	Cerebrovascular Disorders	25.9%
39	Cerebrovascular Insufficiency	25.9%
40	Dementia	25.9%
41	Parkinsonian Disorders	24.9%
42	Pneumocephalus	24.7%
43	Brain Abscess	24.7%
44	Multiple System Atrophy	24.1%
45	Dandy-Walker Syndrome	23.7%
46	Ocular Motility Disorders	23.7%
47	Cyclophoria	23.7%
48	Epilepsy, Complex Partial	23.7%
49	Brain Injuries	23.5%
50	Brain Neoplasms	23.3%
51	Basal Ganglia Cerebrovascular Disease	22.5%
52	Posterior Leukoencephalopathy Syndrome	22.2%
53	Posterior reversible encephalopathy syndrome	22.2%
54	Central Nervous System Infection	22.1%
55	Myelitis	21.9%
56	Marchiafava-Bignami Disease	21.2%
57	Dementia, Vascular	21.2%
58	Brain Death	20.9%
59	Lewy Body Disease	20.5%
60	Meige Syndrome	19.9%
61	Cerebral Ventriculitis	19.9%
62	Epilepsy, Generalized	19.8%
63	Leukomalacia, Periventricular	18.9%
64	Cranial nerve diseases	18.9%
65	Demyelinating Diseases	18.9%
66	Demyelination	18.9%
67	Neuromuscular Diseases	18.9%
68	Chronobiology Disorders	18.9%
69	Epidural Abscess	18.6%
70	Cerebral Palsy	18.5%
71	Pseudotumor Cerebri	18.5%
72	Hypertensive Encephalopathy	18.5%
73	Headache Disorders, Primary	18.5%
74	Headache Disorders, Secondary	18.5%
75	Medication overuse headache	18.5%
76	Amblyopia	18.5%
77	Prion Diseases	18.1%
78	Vascular Headaches	17.9%
79	Hypoxia-Ischemia, Brain	17.8%
80	Myoclonic Epilepsy	17.8%
81	Parkinson Disease	17.2%
82	Neuroleptic Malignant Syndrome	17%
83	Myelinolysis, Central Pontine	17%
84	Stiff-Person Syndrome	17%
85	Creutzfeldt-Jakob disease	16.1%
86	Dystonia Musculorum Deformans	15.9%
87	Huntington Disease	15.9%
88	Cerebellar Neoplasms	15.6%
89	Amnesia, Transient Global	15.2%
90	Spinal Cord Injuries	15.1%
91	Trauma, Nervous System	14.8%
92	Pituitary Diseases	14.8%
93	Spinal Muscular Atrophy	14.7%
94	Progressive Muscular Atrophy	14.7%
95	Progressive supranuclear palsy	14.6%
96	Asterixis	14.5%
97	Ballismus	14.5%
98	Arachnoiditis	14.4%
99	Aseptic Meningitis	14.4%
100	Syringomyelia	14.4%
101	Essential Tremor	14.4%
102	Familial Tremor	14.4%
103	Pneumorrhachis	14.4%
104	Writer's Cramp	14.4%
105	Subacute Combined Degeneration	14.4%
106	Nervous System Neoplasms	14.3%
107	Neurologic Manifestations	14.3%
108	Neurotoxicity Syndromes	14.3%
109	Presenile dementia	14.2%
110	Senile dementia	14.2%
111	Motor Neuron Disease	14.2%
112	Carotid Artery Diseases	14.1%
113	Brain Ischemia	14.1%
114	Cerebrovascular accident	14.1%
115	Kluver-Bucy Syndrome	14.1%
116	Vasospasm, Intracranial	14.1%
117	Intracranial Arterial Diseases	14.1%
118	Limbic Encephalitis	13.6%
119	Meningitis, Bacterial	13.6%
120	Meningitis, Fungal	13.6%
121	Striatonigral Degeneration	13.4%
122	Brain Injuries, Diffuse	12.8%
123	Traumatic Brain Injury	12.8%
124	Cerebellar Ataxia	12.7%
125	Supratentorial Neoplasms	12.7%
126	Poliomyelitis	12.7%
127	Chronic Fatigue Syndrome	12.7%
128	Leukoencephalopathy, Progressive Multifocal	12.6%
129	Amyotrophic Lateral Sclerosis	12.6%
130	Vasculitis, Central Nervous System	12.2%
131	Persistent Vegetative State	12%
132	Paraneoplastic Cerebellar Degeneration	11.9%
133	Juvenile Myoclonic Epilepsy	11.8%
134	Sleep Wake Disorders	11.7%
135	Spinal Cord Neoplasms	11.7%
136	Hepatolenticular Degeneration	11.5%
137	Shy-Drager Syndrome	11.5%
138	Reye Syndrome	11.3%
139	Pituitary Apoplexy	11.3%
140	Intracranial Embolism and Thrombosis	11.3%
141	Hepatic Encephalopathy	11.3%
142	Restless Legs Syndrome	11.2%
143	Lupus Vasculitis, Central Nervous System	11.2%
144	Brain Infarction	11.1%
145	Central Nervous System Fungal Infections	11.1%
146	Conus Medullaris Syndrome	11.1%
147	Spinal Cord Vascular Diseases	11.1%
148	Basal Ganglia Hemorrhage	11.1%
149	Post-Traumatic Headache	11.1%
150	Tension Headache	11.1%
151	Migraine Disorders	11.1%
152	Abdominal Migraine	11.1%
153	Status Migrainosus	11.1%
154	Cervicogenic Headache	11.1%
155	MPTP Poisoning	10.8%
156	Polyradiculoneuropathy	10.8%
157	Polyradiculoneuritis	10.8%
158	Autonomic Dysreflexia	10.7%
159	Complex Regional Pain Syndromes	10.7%
160	Ophthalmoplegic Migraine	10.6%
161	Toxoplasmosis, Cerebral	10.6%
162	Encephalomyelitis, Acute Disseminated	10.5%
163	Brain Hemorrhage, Traumatic	10.5%
164	Akathisia, Drug-Induced	10.4%
165	Carotid Artery Injuries	10.3%
166	Leukoencephalitis, Acute Hemorrhagic	10.1%
167	Miller Fisher Syndrome	9.9%
168	Brain Diseases, Metabolic, Inborn	9.5%
169	Pituitary Adenoma	9.4%
170	Pituitary Neoplasms	9.4%
171	Friedreich Ataxia	9.4%
172	Dysautonomia	9.3%
173	Vagus Nerve Disorder	9.3%
174	Glossopharyngeal Neuralgia	9.3%
175	Abducens Nerve Diseases	9.3%
176	Heavy Metal Poisoning, Nervous System	9.3%
177	Neuromuscular Junction Diseases	9.3%
178	Tauopathies	9.3%
179	Trochlear Nerve Diseases	9.3%
180	Peripheral Nervous System Diseases	9.3%
181	Myelitis, Transverse	9.3%
182	Mitochondrial Encephalomyopathies	9.2%
183	Opsoclonus-Myoclonus Syndrome	9.1%
184	Central Nervous System Bacterial Infections	9%
185	Peripheral Nerve Injuries	8.7%
186	Myasthenia Gravis	8.6%
187	Empty Sella Syndrome	8.5%
188	Hyperpituitarism	8.5%
189	Hypopituitarism	8.5%
190	Hypophysitis	8.5%
191	Canavan Disease	8.5%
192	Alexander Disease	8.5%
193	Dyskinesia, Drug-Induced	8.5%
194	Cerebral Arterial Diseases	8.3%
195	Vertebrobasilar Insufficiency	8.3%
196	Basilar Artery Stenosis	8.3%
197	Vertebral Artery Stenosis	8.3%
198	Intracranial Hemorrhage, Hypertensive	8.3%
199	Transient Cerebral Ischemia	8.3%
200	Wernicke Encephalopathy	8.1%
201	AIDS Dementia Complex	8.1%
202	Auditory Perceptual Disorders	8.1%
203	Moyamoya Disease	8%
204	Scrapie	7.9%
205	Central Cord Syndrome	7.9%
206	Chorea	7.7%
207	Diffuse Axonal Injury	7.6%
208	Brain Stem Neoplasms	7.6%
209	Putaminal Hemorrhage	7.6%
210	Tuberculosis, Meningeal	7.5%
211	Sleep Disorders, Circadian Rhythm	7.4%
212	Cerebral Infarction	7.4%
213	Brain Stem Infarctions	7.4%
214	Myopathy	7.4%
215	Optic Neuropathy	7.4%
216	Cluster Headache	7.3%
217	Migraine with Aura	7.3%
218	Familial Hemiplegic Migraine	7.3%
219	Chronic Paroxysmal Hemicrania	7.3%
220	SUNCT Syndrome	7.3%
221	Paroxysmal Hemicrania	7.3%
222	Progressive bulbar palsy	7.3%
223	Bulbar palsy	7.3%
224	Kernicterus	7.2%
225	Lambert-Eaton Myasthenic Syndrome	7.2%
226	Botulism	7.1%
227	Central Nervous System Cysts	7.1%
228	Facial Nerve Diseases	7.1%
229	Craniocerebral Trauma	7.1%
230	Parasomnia	7.1%
231	Dyssomnias	7.1%
232	Vestibulocochlear Nerve Diseases	7%
233	Decerebrate State	7%
234	Hemiparesis	7%
235	Hydranencephaly	7%
236	Meningism	7%
237	Neural Tube Defects	7%
238	Paresis	7%
239	Seizures	7%
240	Sensation Disorders	7%
241	Tethered Cord Syndrome	7%
242	Central Nervous System Neoplasms	7%
243	Complex partial seizures	7%
244	Iniencephaly	7%
245	Craniorachischisis	7%
246	Exencephaly	7%
247	Monoparesis	7%
248	Septo-Optic Dysplasia	7%
249	Cortical Dysplasia	7%
250	Neurogenic Inflammation	7%
251	Gait Disorders, Neurologic	7%
252	Neuromuscular Manifestations	7%
253	Malformations of Cortical Development	7%
254	Guillain-Barre Syndrome	6.9%
255	Sweating, Gustatory	6.9%
256	Auriculotemporal Syndrome	6.9%
257	Vertebral Artery Dissection	6.9%
258	Frontotemporal dementia	6.9%
259	Infarction, Middle Cerebral Artery	6.9%
260	Infarction, Anterior Cerebral Artery	6.9%
261	Infarction, Posterior Cerebral Artery	6.9%
262	Carotid Stenosis	6.7%
263	Intracranial Aneurysm	6.7%
264	Intracranial Arteriosclerosis	6.7%
265	Cerebral Atherosclerosis	6.7%
266	Subarachnoid Hemorrhage	6.7%
267	Cerebral Arteriosclerosis	6.7%
268	Cerebral Hemorrhage	6.7%
269	Cerebral Thrombosis	6.7%
270	Intracranial Embolism	6.7%
271	Intracranial Thrombosis	6.7%
272	MELAS Syndrome	6.5%
273	Meningitis, Cryptococcal	6.4%
274	Meningitis, Listeria	6.4%
275	Brain Contusion	6.4%
276	Torticollis	6.4%
277	Meningitis, Haemophilus	6.4%
278	Meningitis, Pneumococcal	6.4%
279	Olfactory Nerve Injuries	6.2%
280	Causalgia	6.1%
281	Ataxia Telangiectasia	6.1%
282	Adrenoleukodystrophy	6.1%
283	Spinal Cord Ischemia	6%
284	Horner Syndrome	6%
285	Tuberculosis, Central Nervous System	5.9%
286	Pupil Disorders	5.8%
287	Neurobehavioral Manifestations	5.8%
288	Subarachnoid Hemorrhage, Traumatic	5.8%
289	Carotid Artery, Internal, Dissection	5.8%
290	Multiple Sclerosis	5.8%
291	Brain Concussion	5.8%
292	Subacute Sclerosing Panencephalitis	5.8%
293	Paraneoplastic Encephalomyelitis	5.7%
294	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	5.6%
295	Reflex Sympathetic Dystrophy	5.6%
296	Nocturnal Myoclonus Syndrome	5.6%
297	Uveomeningoencephalitic Syndrome	5.6%
298	Hyperprolactinemia	5.6%
299	Sturge-Weber Syndrome	5.6%
300	Vertigo	5.6%
301	Alcohol-Induced Disorders, Nervous System	5.6%
302	Carotid Artery Thrombosis	5.6%
303	Subclavian Steal Syndrome	5.5%
304	Pick Disease of the Brain	5.5%
305	Lateral Medullary Syndrome	5.5%
306	Giant Cell Arteritis	5.4%
307	Temporal Arteritis	5.4%
308	Neuromyelitis Optica	5.3%
309	Facial Nerve Injuries	5.3%
310	Jet Lag Syndrome	5.2%
311	Choroid Plexus Papilloma	5%
312	Ophthalmoplegia	4.9%
313	External Ophthalmoplegia	4.9%
314	Neuroaspergillosis	4.9%
315	Neuritis	4.8%
316	Polyneuritis	4.8%
317	Radiculitis	4.8%
318	Polyneuropathy	4.8%
319	Mononeuritis	4.8%
320	Mononeuropathies	4.8%
321	Brachial Plexus Neuropathies	4.8%
322	Radiculopathy	4.8%
323	Mononeuropathy Multiplex	4.8%
324	Nerve Root Compression	4.8%
325	Alice in Wonderland Syndrome	4.8%
326	Voice Disorders	4.8%
327	Voice Disturbance	4.8%
328	Tuberous Sclerosis	4.7%
329	Refsum Disease	4.7%
330	Smith-Magenis syndrome	4.7%
331	Dural Arteriovenous Fistula	4.7%
332	Myasthenia Gravis, Autoimmune, Experimental	4.6%
333	Acromegaly	4.5%
334	Acrodynia	4.5%
335	Tardive Dyskinesia	4.4%
336	Cerebral Amyloid Angiopathy	4.4%
337	Sinus Thrombosis, Intracranial	4.4%
338	Vocal Cord Paralysis	4.3%
339	Pseudorabies	4.2%
340	Galactosemias	4.2%
341	Urea Cycle Disorders, Inborn	4.2%
342	Tyrosinemias	4.2%
343	Neurosyphilis	4%
344	Brachial Plexus Neuritis	4%
345	Neuralgic Amyotrophy	4%
346	Reflex, Abnormal	4%
347	Hyporeflexia	4%
348	Hyperreflexia	4%
349	Charcot-Marie-Tooth Disease	3.9%
350	Myotonia Congenita	3.8%
351	Hematoma, Subdural	3.8%
352	Hematoma, Epidural, Cranial	3.8%
353	Homocystinuria	3.8%
354	Cerebrospinal Fluid Otorrhea	3.8%
355	Cerebrospinal Fluid Rhinorrhea	3.8%
356	Neuritis, Autoimmune, Experimental	3.8%
357	Gait Ataxia	3.7%
358	Leigh Disease	3.7%
359	Myositis	3.7%
360	Optic Atrophy	3.7%
361	Optic Neuritis	3.7%
362	Papilledema	3.7%
363	Strabismus	3.7%
364	Tolosa-Hunt Syndrome	3.7%
365	Isaacs syndrome	3.7%
366	Arsenic Poisoning	3.7%
367	Myotonic Disorders	3.7%
368	Myasthenic Syndromes, Congenital	3.7%
369	Diabetic Neuropathies	3.6%
370	Facial Injuries	3.6%
371	Facial Neuralgia	3.6%
372	Diabetic Amyotrophy	3.6%
373	Diabetic Autonomic Neuropathy	3.6%
374	Sleep Talking	3.6%
375	Alcohol Withdrawal Seizures	3.6%
376	Manganese Poisoning	3.6%
377	Sleep Disorders, Intrinsic	3.6%
378	Orthostatic intolerance	3.6%
379	West Nile Fever	3.6%
380	Anosmia	3.6%
381	Ataxia	3.6%
382	Athetosis	3.6%
383	Catalepsy	3.6%
384	Dystonia	3.6%
385	Hemiplegia	3.6%
386	Locked-In Syndrome	3.6%
387	Meningeal Neoplasms	3.6%
388	Meningomyelocele	3.6%
389	Muscle Hypertonia	3.6%
390	Muscle hypotonia	3.6%
391	Myoclonus	3.6%
392	Myotonia	3.6%
393	Neuralgia	3.6%
394	Paraplegia	3.6%
395	Pseudobulbar Palsy	3.6%
396	Quadriplegia	3.6%
397	Spasm	3.6%
398	Spastic Paraplegia	3.6%
399	Status Epilepticus	3.6%
400	Taste Disorders	3.6%
401	Tremor	3.6%
402	Spina Bifida	3.6%
403	Monoplegia	3.6%
404	Hypokinesia	3.6%
405	Paraparesis	3.6%
406	Bradykinesia	3.6%
407	Waxy flexibility	3.6%
408	Action Tremor	3.6%
409	Resting Tremor	3.6%
410	Dysosmia	3.6%
411	Quadriparesis	3.6%
412	Mercury Poisoning, Nervous System	3.6%
413	Olfaction Disorders	3.6%
414	Myokymia	3.6%
415	Lead Poisoning, Nervous System	3.6%
416	Vestibular Neuronitis	3.6%
417	Somatosensory Disorders	3.6%
418	Neuropathic pain	3.6%
419	Hyperkinesia	3.6%
420	Intention tremor	3.6%
421	Anterior Spinal Artery Syndrome	3.6%
422	Fabry Disease	3.6%
423	Coma, Post-Head Injury	3.5%
424	Lyme Neuroborreliosis	3.4%
425	Cavernous Sinus Thrombosis	3.3%
426	Sagittal Sinus Thrombosis	3.3%
427	Akathisia	3.2%
428	Restlessness	3.2%
429	Psychomotor Agitation	3.2%
430	Prolactinoma	3.2%
431	Growth Hormone-Secreting Pituitary Adenoma	3.2%
432	Menkes Kinky Hair Syndrome	3.2%
433	Multiple Sclerosis, Chronic Progressive	3.2%
434	Multiple Sclerosis, Relapsing-Remitting	3.2%
435	Tarsal Tunnel Syndrome	3.2%
436	Cauda Equina Syndrome	3.2%
437	Hand-Arm Vibration Syndrome	3.1%
438	Myotonic Dystrophy	3.1%
439	Vision Disorders	3%
440	Metamorphopsia	3%
441	Visual Impairment	3%
442	Fibromyalgia	3%
443	Optic Neuropathy, Ischemic	3%
444	Anterior Ischemic Optic Neuropathy	3%
445	Medial Tibial Stress Syndrome	3%
446	Facial Hemiatrophy	3%
447	Melkersson-Rosenthal Syndrome	3%
448	Mitochondrial Myopathies	3%
449	Anisocoria	3%
450	Confusion	3%
451	Facial paralysis	3%
452	Lethargy	3%
453	Memory Disorders	3%
454	Muscle Cramp	3%
455	Perceptual Disorders	3%
456	Psychomotor Disorders	3%
457	Tonic Pupil	3%
458	Eosinophilia-Myalgia Syndrome	3%
459	Anhedonia	3%
460	Disorientation	3%
461	Facial Paresis	3%
462	Memory Loss	3%
463	Hemisensory Neglect	3%
464	Dysacusis	3%
465	Sleep Bruxism	2.9%
466	Toxoplasmosis, Congenital	2.9%
467	Anencephaly	2.9%
468	Meningocele	2.9%
469	Muscular Atrophy	2.9%
470	Respiratory Paralysis	2.9%
471	Encephalocele	2.9%
472	Malaria, Cerebral	2.9%
473	Tetany	2.9%
474	Neurocysticercosis	2.9%
475	Zellweger Syndrome	2.8%
476	Nelson Syndrome	2.8%
477	Gait Apraxia	2.7%
478	Hematoma, Subdural, Intracranial	2.7%
479	Hematoma, Subdural, Chronic	2.7%
480	Hematoma, Subdural, Acute	2.7%
481	Sciatic Neuropathy	2.6%
482	Ulnar Neuropathies	2.6%
483	Lesion of Sciatic Nerve	2.6%
484	Ulnar Neuritis	2.6%
485	Radial nerve compression	2.6%
486	Radial Tunnel Syndrome	2.6%
487	Peroneal Neuropathies	2.6%
488	Radial Neuropathy	2.6%
489	Median Neuropathy	2.6%
490	Sciatic Nerve Palsy	2.6%
491	Femoral Neuropathy	2.6%
492	Tibial Neuropathy	2.6%
493	Ulnar Nerve Palsy	2.6%
494	Postural Orthostatic Tachycardia Syndrome	2.6%
495	Radial nerve palsy	2.6%
496	Acoustic Neuroma	2.6%
497	Carpal Tunnel Syndrome	2.6%
498	neurofibroma	2.5%
499	Sciatica	2.5%
500	Duane Retraction Syndrome	2.5%
501	Amyloid Neuropathies, Familial	2.5%
502	Alstrom Syndrome	2.5%
503	Consciousness Disorders	2.5%
504	Mental Retardation	2.5%
505	Muscle Weakness	2.5%
506	Depressed Level of Consciousness	2.5%
507	Mental deficiency	2.5%
508	Intellectual Disability	2.5%
509	Mobius Syndrome	2.5%
510	Bell Palsy	2.5%
511	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.5%
512	Catatonia	2.5%
513	Herpes Zoster Oticus	2.5%
514	Familial Periodic Paralysis	2.5%
515	Aphonia	2.4%
516	Sleep Deprivation	2.4%
517	Dysphonia	2.4%
518	Optic Nerve Glioma	2.4%
519	Glycogen storage disease type II	2.2%
520	Waterhouse-Friderichsen Syndrome	2.2%
521	Myalgia	2.1%
522	Neuronal Ceroid-Lipofuscinoses	2.1%
523	Thoracic Outlet Syndrome	2%
524	Esotropia	2%
525	Exotropia	2%
526	Hypotension, Orthostatic	2%
527	Sleep Apnea Syndromes	2%
528	Polymyositis	2%
529	Post-Exercise Hypotension	2%
530	Disorders of Excessive Somnolence	2%
531	Sleep Initiation and Maintenance Disorders	2%
532	Night Terrors	2%
533	Somnambulism	2%
534	Trigeminal Nerve Disorder	2%
535	Transient Insomnia	2%
536	Sleep Paralysis	2%
537	Chronic Insomnia	2%
538	REM Sleep Behavior Disorder	2%
539	Hypersomnia	2%
540	Dermal Sinus	2%
541	Dysgeusia	2%
542	Formication	2%
543	Hyperalgesia	2%
544	Hyperesthesia	2%
545	Hypesthesia	2%
546	Language Disorders	2%
547	Numbness	2%
548	Paresthesia	2%
549	Paraparesis, Spastic	2%
550	Spina Bifida Cystica	2%
551	Trismus	2%
552	Spina Bifida Occulta	2%
553	Epilepsia Partialis Continua	2%
554	Hypogeusia	2%
555	Meningeal Carcinomatosis	2%
556	Brown-Sequard Syndrome	2%
557	Lissencephaly	2%
558	Polymicrogyria	2%
559	Pachygyria	2%
560	Schizencephaly	2%
561	Lockjaw	2%
562	Allodynia	2%
563	Lead Poisoning, Nervous System, Childhood	2%
564	Lead Poisoning, Nervous System, Adult	2%
565	Periventricular Nodular Heterotopia	2%
566	Ageusia	2%
567	Cubital Tunnel Syndrome	1.9%
568	Aicardi's syndrome	1.9%
569	Hoarseness	1.9%
570	Cockayne Syndrome	1.8%
571	Alcohol Withdrawal Delirium	1.8%
572	Classical Lissencephalies and Subcortical Band Heterotopias	1.8%
573	Eye Injuries	1.7%
574	Muscular Dystrophy	1.6%
575	Congenital nystagmus	1.6%
576	Orbital Myositis	1.6%
577	Holoprosencephaly	1.6%
578	Diplopia	1.6%
579	Muscle Rigidity	1.6%
580	Muscle Spasticity	1.6%
581	Scotoma	1.6%
582	Photophobia	1.6%
583	Cogwheel Rigidity	1.6%
584	Hemifacial Spasm	1.6%
585	Amaurosis	1.6%
586	Blindness	1.6%
587	Nuchal Rigidity	1.6%
588	Pyomyositis	1.6%
589	Agnosia	1.6%
590	Apraxias	1.6%
591	Hallucinations	1.6%
592	Hemianopsia	1.6%
593	Hyperacusis	1.6%
594	Tinnitus	1.6%
595	Visual Agnosia	1.6%
596	Anosognosia	1.6%
597	Wernicke-Korsakoff Syndrome	1.6%
598	Phonophobia	1.6%
599	Hearing Loss	1.6%
600	Sarcopenia	1.6%
601	Polyradiculopathy	1.6%
602	Gaucher Disease	1.5%
603	Optic Atrophy, Hereditary, Leber	1.4%
604	Alexia	1.4%
605	Dyslexia	1.4%
606	Amnesia	1.4%
607	Delirium	1.4%
608	Dissociative Amnesia	1.4%
609	Color blindness	1.4%
610	Global Amnesia	1.4%
611	Cri-du-Chat Syndrome	1.4%
612	Down Syndrome	1.4%
613	Trisomy 21	1.4%
614	POEMS Syndrome	1.3%
615	Meningioma	1.3%
616	Williams Syndrome	1.3%
617	Microcephaly	1.3%
618	Macrocephaly	1.3%
619	Hypokalemic periodic paralysis	1.3%
620	Porencephaly	1.3%
621	Kearns-Sayre syndrome	1.2%
622	Sleep Apnea, Obstructive	1.2%
623	Sleep Apnea, Central	1.2%
624	Narcolepsy	1.2%
625	Trigeminal Neuralgia	1.2%
626	Kleine-Levin Syndrome	1.2%
627	Agraphia	1.2%
628	Anomia	1.2%
629	Cluttering	1.2%
630	Language Development Disorders	1.2%
631	Speech Disorders	1.2%
632	Syncope	1.2%
633	Stupor	1.2%
634	Dysgraphia	1.2%
635	Presyncope	1.2%
636	Dyslalia	1.2%
637	Prader-Willi Syndrome	1.2%
638	Niemann-Pick Disease, Type C	1.1%
639	Phantom pain	1.1%
640	Phantom Limb Pain	1.1%
641	Neurofibrosarcoma	1.1%
642	Tay-Sachs Disease	1.1%
643	Eye Burns	1%
644	Welander Distal Myopathy	1%
645	Amaurosis Fugax	1%
646	Blindness, Cortical	1%
647	Dyscalculia	1%
648	Rett Syndrome	1%
649	Deafness	1%
650	Hearing Loss, Sudden	1%
651	Gerstmann Syndrome	1%
652	Hearing Loss, Bilateral	1%
653	Hearing Loss, High-Frequency	1%
654	Hearing Loss, Mixed Conductive-Sensorineural	1%
655	Prosopagnosia	1%
656	Apraxia, Ideomotor	1%
657	Charles Bonnet Syndrome	1%
658	Hearing Loss, Unilateral	1%
659	Complete Hearing Loss	1%
660	Alien Hand Syndrome	1%
661	Deaf Mutism	1%
662	Rubinstein-Taybi Syndrome	0.9%
663	Dermatomyositis	0.8%
664	Corneal Scar	0.8%
665	Muscular Dystrophy, Duchenne	0.8%
666	Retrograde amnesia	0.8%
667	Amnesia, Anterograde	0.8%
668	Cataplexy	0.8%
669	Aphasia	0.8%
670	Articulation Disorders	0.8%
671	Echolalia	0.8%
672	Stuttering	0.8%
673	Dysphasia	0.8%
674	Fragile X Syndrome	0.7%
675	Mutism	0.6%
676	Selective Mutism	0.6%
677	Dysarthria	0.6%
678	Corneal Perforation	0.5%
679	Mucopolysaccharidosis II	0.5%
680	Alexia, Pure	0.5%

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