MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Heart Failure, Systolic

(UMLS:C1135191)

Definition:: Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.
UMLS ID:: C1135191
MeSH ID:: D054143

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.434.676

Synonym(s)

Heart Failure, Systolic

Systolic heart failure

Systolic heart failure, unspecified

Unspecified systolic (congestive) heart failure

failure heart systolic

heart failure systolic

systolic heart failure

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cyclophosphamide		18462404	CTD
2	Nebivolol		17323786	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Heart Failure, Diastolic	46.7%
2	Edema, Cardiac	31.1%
3	Cardiac Tamponade	31%
4	Endocarditis	31%
5	Cardiac Arrest	31%
6	Pericardial effusion	31%
7	Pericarditis	31%
8	Pneumopericardium	31%
9	Cor pulmonale	31%
10	Ventricular Outflow Obstruction	31%
11	Ventricular Dysfunction	31%
12	Cardiomyopathies	31%
13	Pleuropericarditis	31%
14	Myocardial Ischemia	27.9%
15	Aortic Valve Stenosis	26.7%
16	Cardiomyopathy, Dilated	26.7%
17	Pulmonary Valve Stenosis	26.7%
18	Dyspnea, Paroxysmal	23.1%
19	Hypertrophic Cardiomyopathy	21.3%
20	Hypertrophic obstructive cardiomyopathy	21.3%
21	Cardiac Output, High	20.9%
22	Myocardial Stunning	20.9%
23	Low Cardiac Output Syndrome	20.9%
24	Cardiomegaly	20.5%
25	Postpericardiotomy Syndrome	20.5%
26	Cardiac Hypertrophy	20.5%
27	Rheumatic Heart Disease	20.1%
28	Aortic Valve Insufficiency	20%
29	Restrictive cardiomyopathy	20%
30	Endocardial Fibroelastosis	20%
31	Heart Block	20%
32	Heart Rupture, Post-Infarction	20%
33	Mitral Valve Insufficiency	20%
34	Mitral Valve Stenosis	20%
35	Myocarditis	20%
36	Pericarditis, Constrictive	20%
37	Pulmonary Valve Insufficiency	20%
38	Tachycardia	20%
39	Tricuspid Valve Insufficiency	20%
40	Tricuspid Valve Stenosis	20%
41	Tachyarrhythmia	20%
42	Ventricular Dysfunction, Left	20%
43	Right Ventricular Dysfunction	20%
44	Endomyocardial Fibrosis	20%
45	Carditis	20%
46	Supravalvular aortic stenosis	19.6%
47	Lown-Ganong-Levine Syndrome	19.6%
48	Tricuspid Atresia	18.5%
49	Arrhythmogenic Right Ventricular Dysplasia	18.5%
50	Vascular Diseases	18.5%
51	Coronary heart disease	17.8%
52	Myocardial Infarction	17.8%
53	Acute Coronary Syndrome	17.8%
54	Myocardial Reperfusion Injury	17.7%
55	Long QT Syndrome	15.9%
56	Aortic Valve Prolapse	14.8%
57	Tricuspid Valve Prolapse	14.8%
58	Takotsubo Cardiomyopathy	14.8%
59	Adams-Stokes Syndrome	14.6%
60	Atrioventricular Block	14.6%
61	Bundle-Branch Block	14.6%
62	Atrial Premature Complexes	14.6%
63	Sinoatrial Block	14.6%
64	Tachycardia, Paroxysmal	14.6%
65	Supraventricular tachycardia	14.6%
66	Tachycardia, Ventricular	14.6%
67	Wolff-Parkinson-White Syndrome	14.6%
68	Tachycardia, Reciprocating	14.6%
69	Sick Sinus Syndrome	14.6%
70	Kounis Syndrome	13.6%
71	Sinus Arrhythmia	13.3%
72	Atrial Fibrillation	13.3%
73	Atrial Flutter	13.3%
74	Ventricular Fibrillation	13.3%
75	Ventricular Flutter	13.3%
76	Parasystole	13.3%
77	Paroxysmal atrial fibrillation	13.3%
78	Bradycardia	13.3%
79	Diabetic Cardiomyopathies	13.3%
80	Aortic coarctation	13.2%
81	Cor Triatriatum	13.2%
82	Coronary Vessel Anomalies	13.2%
83	Patent ductus arteriosus	13.2%
84	Ebstein Anomaly	13.2%
85	Heart Septal Defects	13.2%
86	Tetralogy of Fallot	13.2%
87	Transposition of Great Vessels	13.2%
88	Hypoplastic Left Heart Syndrome	13.2%
89	Cardiomyopathy, Alcoholic	13.2%
90	Sudden Cardiac Death	13.2%
91	Left Ventricular Hypertrophy	13.2%
92	Right Ventricular Hypertrophy	13.2%
93	Angina Pectoris	13.2%
94	Chagas Cardiomyopathy	13.1%
95	Coronary Aneurysm	13.1%
96	Coronary Occlusion	13%
97	Microvascular Angina	13%
98	Coronary Stenosis	13%
99	ST segment elevation myocardial infarction	13%
100	Bacterial Endocarditis	12.3%
101	Coronary Thrombosis	12.2%
102	Pregnancy Complications, Cardiovascular	12.2%
103	Cardiovascular Abnormalities	12.2%
104	Coronary Artery Disease	12.2%
105	Tachycardia, Atrioventricular Nodal Reentry	12%
106	Tachycardia, Ectopic Atrial	12%
107	Tachycardia, Ectopic Junctional	12%
108	Sinus Tachycardia	12%
109	Torsades de Pointes	12%
110	Accelerated Idioventricular Rhythm	12%
111	Carcinoid Heart Disease	11.7%
112	Romano-Ward Syndrome	11.7%
113	Coronary Restenosis	10.8%
114	Dextrocardia	10.6%
115	Aneurysm	10.3%
116	Angiomatosis	10.3%
117	Aortic Diseases	10.3%
118	Arterial Occlusive Diseases	10.3%
119	Hyperemia	10.3%
120	Hypotension	10.3%
121	Superior Vena Cava Syndrome	10.3%
122	Telangiectasis	10.3%
123	Vasculitis	10.3%
124	Venous Insufficiency	10.3%
125	Peripheral Vascular Diseases	10.3%
126	Embolism and Thrombosis	10.3%
127	Angiodysplasia	10.3%
128	Capillary Leak Syndrome	10.3%
129	Prehypertension	10.3%
130	Shock, Cardiogenic	9.8%
131	Sinus Arrest, Cardiac	9.8%
132	Aortopulmonary Septal Defect	9.7%
133	Double Outlet Right Ventricle	9.7%
134	Endocardial Cushion Defects	9.7%
135	Myocardial bridging	9.7%
136	Aorticopulmonary Septal Defect	9.7%
137	Angina, Unstable	9.7%
138	Aortic Aneurysm	8.9%
139	Aortitis	8.9%
140	Leriche Syndrome	8.9%
141	Periphlebitis	8.9%
142	Phlebitis	8.9%
143	Thromboangiitis Obliterans	8.9%
144	Truncus Arteriosus, Persistent	8%
145	Angina Pectoris, Variant	8%
146	Postphlebitic Syndrome	7.7%
147	Noonan Syndrome	7.6%
148	Embolism, Amniotic Fluid	7.6%
149	Vascular System Injuries	7.3%
150	Retinal Vein Occlusion	7.2%
151	Subacute Bacterial Endocarditis	7.1%
152	Compartment syndromes	7%
153	Hepatic Veno-Occlusive Disease	7%
154	Peliosis Hepatis	7%
155	Varicocele	7%
156	Thrombophlebitis	6.9%
157	Cerebrovascular Disorders	6.8%
158	Diabetic Angiopathies	6.8%
159	Reperfusion Injury	6.8%
160	Splenic Infarction	6.8%
161	Cerebrovascular Insufficiency	6.8%
162	Vascular Neoplasms	6.8%
163	Spinal Cord Vascular Diseases	6.8%
164	Vasoplegia	6.8%
165	Blue Toe Syndrome	6.8%
166	Marfan Syndrome	6.8%
167	Hemorrhoids	6.7%
168	Thoracic Outlet Syndrome	6.7%
169	Aneurysm, Dissecting	6.7%
170	Arteriosclerosis	6.7%
171	Arteritis	6.7%
172	Embolism	6.7%
173	Erythromelalgia	6.7%
174	Fibromuscular Dysplasia	6.7%
175	Malignant Hypertension	6.7%
176	Raynaud Disease	6.7%
177	Thromboembolism	6.7%
178	Thrombosis	6.7%
179	Essential Hypertension	6.7%
180	Aneurysm, Ruptured	6.7%
181	Iliac Aneurysm	6.7%
182	Malignant Atrophic Papulosis	6.7%
183	Pulmonary artery stenosis	6.7%
184	White Coat Hypertension	6.7%
185	Systemic Vasculitis	6.7%
186	Embolus	6.7%
187	Shwartzman Phenomenon	6.6%
188	May-Thurner Syndrome	6.6%
189	Arteriovenous fistula	6.5%
190	Aortic Aneurysm, Abdominal	6.5%
191	Aortic Aneurysm, Thoracic	6.5%
192	Aortic Rupture	6%
193	Intracranial Embolism and Thrombosis	5.7%
194	Carotid Stenosis	5.7%
195	Intracranial Aneurysm	5.7%
196	Carotid Artery Thrombosis	5.5%
197	Hand-Arm Vibration Syndrome	5.4%
198	Optic Neuropathy, Ischemic	5.2%
199	Anterior Ischemic Optic Neuropathy	5.2%
200	Mesenteric vascular insufficiency	5.2%
201	Moyamoya Disease	5.1%
202	Angioedema	5%
203	Colitis, Ischemic	5%
204	Arteriosclerosis Obliterans	4.9%
205	Atherosclerosis	4.9%
206	Air Embolism	4.9%
207	Endarteritis	4.9%
208	Polyarteritis Nodosa	4.9%
209	Takayasu Arteritis	4.9%
210	Venous Thrombosis	4.9%
211	Deep Vein Thrombosis	4.9%
212	Williams Syndrome	4.9%
213	Venous Thromboembolism	4.9%
214	Scimitar Syndrome	4.9%
215	Intracranial Arteriosclerosis	4.9%
216	Cerebral Atherosclerosis	4.9%
217	Cerebral Arteriosclerosis	4.9%
218	Retinal Artery Occlusion	4.5%
219	Retinal Vasculitis	4.5%
220	Hypertensive Retinopathy	4.5%
221	Vasculitis, Central Nervous System	4.5%
222	Anterior Compartment Syndrome	4.4%
223	Vasculitis, Leukocytoclastic, Cutaneous	4.4%
224	Gastric Antral Vascular Ectasia	4.4%
225	Abdominal Compartment Syndrome	4.4%
226	Cerebral Thrombosis	4.4%
227	Intracranial Embolism	4.4%
228	Intracranial Thrombosis	4.4%
229	Carotid Artery Diseases	4.4%
230	Brain Ischemia	4.4%
231	Ectopia Cordis	4.4%
232	Hypotension, Orthostatic	4.4%
233	Cerebrovascular accident	4.4%
234	Varicose Ulcer	4.4%
235	Vasospasm, Intracranial	4.4%
236	Spinal Cord Ischemia	4.4%
237	Intracranial Arterial Diseases	4.4%
238	Primary Graft Dysfunction	4.4%
239	Single umbilical artery	4.4%
240	Post-Exercise Hypotension	4.4%
241	Brain Infarction	3.9%
242	Sinus Thrombosis, Intracranial	3.8%
243	Turner Syndrome	3.7%
244	Giant Cell Arteritis	3.7%
245	Temporal Arteritis	3.7%
246	Kearns-Sayre syndrome	3.5%
247	Cavernous Sinus Thrombosis	3.5%
248	Sagittal Sinus Thrombosis	3.5%
249	Lemierre Syndrome	3.4%
250	Mesenteric Vascular Occlusion	3.4%
251	Mucocutaneous Lymph Node Syndrome	3.4%
252	Intermittent Claudication	3.4%
253	Pulmonary Embolism	3.4%
254	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.4%
255	Diabetic Retinopathy	3.4%
256	Sturge-Weber Syndrome	3.4%
257	Livedo Reticularis	3.3%
258	Renal hypertension	3.3%
259	Renal Artery Obstruction	3.3%
260	Renal Artery Stenosis	3.3%
261	No-Reflow Phenomenon	3.3%
262	Hemangioma, Cavernous	3.3%
263	Basal Ganglia Cerebrovascular Disease	3.3%
264	Vertebral Artery Dissection	3.3%
265	Vascular Headaches	3.3%
266	Scurvy	3.3%
267	CREST Syndrome	3.2%
268	Cerebral Arterial Diseases	3.2%
269	Vertebrobasilar Insufficiency	3.2%
270	Anterior Spinal Artery Syndrome	3.2%
271	Basilar Artery Stenosis	3.2%
272	Vertebral Artery Stenosis	3.2%
273	Intracranial Hemorrhage, Hypertensive	3.2%
274	Transient Cerebral Ischemia	3.2%
275	Subarachnoid Hemorrhage, Traumatic	3.2%
276	Carotid Artery, Internal, Dissection	3.2%
277	Cerebral Infarction	3.2%
278	Brain Stem Infarctions	3.2%
279	Infarction, Middle Cerebral Artery	3.2%
280	Infarction, Anterior Cerebral Artery	3.2%
281	Infarction, Posterior Cerebral Artery	3.2%
282	Kartagener Syndrome	3.1%
283	Lateral Medullary Syndrome	2.9%
284	Hepatic Vein Thrombosis	2.8%
285	Budd-Chiari Syndrome	2.8%
286	Carotid Artery Injuries	2.8%
287	Pulmonary Infarction	2.7%
288	Dural Arteriovenous Fistula	2.7%
289	Subclavian Steal Syndrome	2.7%
290	Ischemic contracture	2.7%
291	Angioedemas, Hereditary	2.6%
292	Cryoglobulinemia	2.6%
293	Leukomalacia, Periventricular	2.6%
294	Diabetic Foot	2.6%
295	Basal Ganglia Hemorrhage	2.5%
296	Hypertension, Renovascular	2.4%
297	Subarachnoid Hemorrhage	2.4%
298	Hypoxia-Ischemia, Brain	2.4%
299	Cerebral Hemorrhage	2.4%
300	Hereditary Angioedema Type III	2.4%
301	Hereditary Angioedema Types I and II	2.4%
302	Shy-Drager Syndrome	2.2%
303	Purpura, Hyperglobulinemic	2.2%
304	Putaminal Hemorrhage	2.2%
305	Granulomatosis with polyangiitis	2.1%
306	Dementia, Vascular	2%
307	Cerebral Amyloid Angiopathy	2%
308	Pituitary Apoplexy	2%
309	Behcet Syndrome	1.9%
310	Waldenstrom Macroglobulinemia	1.9%
311	Multiple Myeloma	1.9%
312	Ataxia Telangiectasia	1.7%
313	Pseudoxanthoma Elasticum	1.7%
314	Rheumatoid Vasculitis	1.6%
315	Lupus Vasculitis, Central Nervous System	1.6%
316	Hematoma, Subdural	1.2%
317	Hematoma, Epidural, Cranial	1.2%
318	Hematoma, Subdural, Intracranial	1%
319	Hematoma, Subdural, Chronic	1%
320	Hematoma, Subdural, Acute	1%
321	Brain Hemorrhage, Traumatic	1%
322	MELAS Syndrome	1%
323	Fabry Disease	0.7%

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