MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Complex Regional Pain Syndromes

(UMLS:C0458219)

Definition:: Conditions characterized by pain involving an extremity or other body region, HYPERESTHESIA, and localized autonomic dysfunction following injury to soft tissue or nerve. The pain is usually associated with ERYTHEMA; SKIN TEMPERATURE changes, abnormal sudomotor activity (i.e., changes in sweating due to altered sympathetic innervation) or edema. The degree of pain and other manifestations is out of proportion to that expected from the inciting event. Two subtypes of this condition have been described: type I; (REFLEX SYMPATHETIC DYSTROPHY) and type II; (CAUSALGIA). (From Pain 1995 Oct;63(1):127-33)
UMLS ID:: C0458219
MeSH ID:: D020918

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.177.195|C10.668.829.250

Synonym(s)

Complex Regional Pain Syndromes

Algodystrophy

CRPS

CRPS - complex regional pain syndrome

Complex Regional Pain Syndrome

Complex regional pain syndrome

Complex regional pain syndromes

complex pain regional syndrome

complex regional pain syndrome

10.

complex regional pain syndromes

11.

complexed pain regional syndrome

12.

pain regional complex syndrome

13.

regional complex pain syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ascorbic Acid		20224742	CTD
2	Morphine		18042887	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Brachial Plexus Neuritis	43.3%
2	Neuralgic Amyotrophy	43.3%
3	Tarsal Tunnel Syndrome	39.8%
4	Cauda Equina Syndrome	39.8%
5	Neuritis	38.6%
6	Polyneuritis	38.6%
7	Radiculitis	38.6%
8	Polyneuropathy	38.6%
9	Mononeuritis	38.6%
10	Mononeuropathies	38.6%
11	Brachial Plexus Neuropathies	38.6%
12	Radiculopathy	38.6%
13	Mononeuropathy Multiplex	38.6%
14	Nerve Root Compression	38.6%
15	Guillain-Barre Syndrome	36.1%
16	Motor Neuron Disease	35.1%
17	Dysautonomia	34.9%
18	Autonomic Dysreflexia	34.5%
19	Peripheral Nerve Injuries	33.3%
20	Carpal Tunnel Syndrome	31.9%
21	Sciatica	31.6%
22	Polyradiculoneuropathy	30.9%
23	Polyradiculoneuritis	30.9%
24	Multiple System Atrophy	30.5%
25	Neuromuscular Junction Diseases	30.2%
26	Isaacs syndrome	29.3%
27	Sciatic Neuropathy	29.2%
28	Ulnar Neuropathies	29.2%
29	Lesion of Sciatic Nerve	29.2%
30	Ulnar Neuritis	29.2%
31	Radial nerve compression	29.2%
32	Radial Tunnel Syndrome	29.2%
33	Peroneal Neuropathies	29.2%
34	Radial Neuropathy	29.2%
35	Median Neuropathy	29.2%
36	Sciatic Nerve Palsy	29.2%
37	Femoral Neuropathy	29.2%
38	Tibial Neuropathy	29.2%
39	Ulnar Nerve Palsy	29.2%
40	Radial nerve palsy	29.2%
41	Cubital Tunnel Syndrome	28.9%
42	Diabetic Neuropathies	28.8%
43	Diabetic Amyotrophy	28.8%
44	Diabetic Autonomic Neuropathy	28.8%
45	Stiff-Person Syndrome	28.7%
46	Neuralgia	28.6%
47	Neuropathic pain	28.6%
48	Acrodynia	27.9%
49	Cranial nerve diseases	26.8%
50	Demyelinating Diseases	26.8%
51	Demyelination	26.8%
52	Chronobiology Disorders	26.8%
53	Miller Fisher Syndrome	26.4%
54	Spinal Muscular Atrophy	25.7%
55	Progressive Muscular Atrophy	25.7%
56	Sweating, Gustatory	25.6%
57	Auriculotemporal Syndrome	25.6%
58	Polyradiculopathy	24.6%
59	Hand-Arm Vibration Syndrome	24.3%
60	Progressive bulbar palsy	23.7%
61	Bulbar palsy	23.7%
62	Striatonigral Degeneration	23.7%
63	Myopathy	23.6%
64	Poliomyelitis	23.5%
65	Causalgia	23.3%
66	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	23.3%
67	Amyotrophic Lateral Sclerosis	23%
68	Thoracic Outlet Syndrome	22.2%
69	Myasthenia Gravis	21.9%
70	Chronic Fatigue Syndrome	21.4%
71	Horner Syndrome	21.3%
72	Trauma, Nervous System	20.8%
73	Encephalomyelitis	20.7%
74	Prion Diseases	20.7%
75	Shy-Drager Syndrome	20.3%
76	Ocular Motility Disorders	20.3%
77	Cyclophoria	20.3%
78	Postural Orthostatic Tachycardia Syndrome	20.2%
79	Meningoencephalitis	20%
80	Nervous System Neoplasms	20%
81	Neurologic Manifestations	20%
82	Neurotoxicity Syndromes	20%
83	Neuritis, Autoimmune, Experimental	19.9%
84	neurofibroma	19.8%
85	Restless Legs Syndrome	19.6%
86	Parkinson Disease	19.5%
87	Charcot-Marie-Tooth Disease	18.8%
88	Marchiafava-Bignami Disease	18.8%
89	Ophthalmoplegic Migraine	18.8%
90	Orthostatic intolerance	18.6%
91	Subacute Combined Degeneration	18.5%
92	Botulism	18.1%
93	Lambert-Eaton Myasthenic Syndrome	17.7%
94	Lewy Body Disease	17.7%
95	Spinal Cord Injuries	17.1%
96	Myelitis	16.9%
97	Dandy-Walker Syndrome	16.9%
98	Pneumocephalus	16.8%
99	Asterixis	16.4%
100	Ballismus	16.4%
101	Brain Diseases	16.3%
102	Meningitis	16.3%
103	Movement Disorders	16.3%
104	Pachymeningitis	16.3%
105	Spinal Cord Diseases	16.3%
106	Vagus Nerve Disorder	16.3%
107	Glossopharyngeal Neuralgia	16.3%
108	Abducens Nerve Diseases	16.3%
109	Heavy Metal Poisoning, Nervous System	16.3%
110	Tauopathies	16.3%
111	Trochlear Nerve Diseases	16.3%
112	Leukoencephalitis, Acute Hemorrhagic	16.2%
113	Sleep Wake Disorders	16.2%
114	Progressive supranuclear palsy	16.1%
115	Epidural Abscess	15.6%
116	Olfactory Nerve Injuries	15.6%
117	Myositis	15.5%
118	Myotonic Disorders	15.5%
119	Myasthenic Syndromes, Congenital	15.5%
120	MPTP Poisoning	15.3%
121	Myelitis, Transverse	15.2%
122	Hypotension, Orthostatic	15.1%
123	Subdural Effusion	15.1%
124	Parkinsonian Disorders	15.1%
125	Nocturnal Myoclonus Syndrome	15.1%
126	Post-Exercise Hypotension	15.1%
127	Neuroleptic Malignant Syndrome	15%
128	Myelinolysis, Central Pontine	15%
129	Encephalomyelitis, Acute Disseminated	15%
130	Neuromuscular Diseases	14.6%
131	Neuromyelitis Optica	14.5%
132	Dystonia Musculorum Deformans	14.4%
133	POEMS Syndrome	14.4%
134	Opsoclonus-Myoclonus Syndrome	14.2%
135	Sleep Disorders, Circadian Rhythm	14.1%
136	Myasthenia Gravis, Autoimmune, Experimental	14%
137	Dyskinesia, Drug-Induced	13.6%
138	Central Nervous System Cysts	13.6%
139	Brain Injuries	13.5%
140	Brain Neoplasms	13.4%
141	Multiple Sclerosis	13.4%
142	Spinal Cord Neoplasms	13.4%
143	Myotonia Congenita	13.4%
144	Meige Syndrome	13.3%
145	Facial Nerve Injuries	13.3%
146	Cerebral Ventriculitis	13.3%
147	Myotonic Dystrophy	13.3%
148	Epilepsy, Post-Traumatic	13.2%
149	Amyloid Neuropathies, Familial	13.1%
150	Leukoencephalopathy, Progressive Multifocal	13%
151	Central Nervous System Infection	12.7%
152	Optic Neuropathy	12.7%
153	Fibromyalgia	12.5%
154	Neurofibrosarcoma	12.5%
155	Medial Tibial Stress Syndrome	12.5%
156	Posterior Leukoencephalopathy Syndrome	12.4%
157	Posterior reversible encephalopathy syndrome	12.4%
158	Lafora Disease	12.4%
159	Unverricht-Lundborg Syndrome	12.4%
160	Mitochondrial Myopathies	12.3%
161	Limbic Encephalitis	12.3%
162	Facial Nerve Diseases	12.3%
163	Craniocerebral Trauma	12.3%
164	Parasomnia	12.3%
165	Dyssomnias	12.3%
166	Scrapie	12.2%
167	Eosinophilia-Myalgia Syndrome	12.2%
168	Central Cord Syndrome	12.2%
169	Huntington Disease	12.2%
170	Presenile dementia	12.1%
171	Senile dementia	12.1%
172	Meningitis, Bacterial	12.1%
173	Meningitis, Fungal	12.1%
174	Vestibulocochlear Nerve Diseases	12.1%
175	Decerebrate State	12.1%
176	Hemiparesis	12.1%
177	Hydranencephaly	12.1%
178	Meningism	12.1%
179	Neural Tube Defects	12.1%
180	Paresis	12.1%
181	Seizures	12.1%
182	Sensation Disorders	12.1%
183	Tethered Cord Syndrome	12.1%
184	Central Nervous System Neoplasms	12.1%
185	Complex partial seizures	12.1%
186	Iniencephaly	12.1%
187	Craniorachischisis	12.1%
188	Exencephaly	12.1%
189	Monoparesis	12.1%
190	Septo-Optic Dysplasia	12.1%
191	Cortical Dysplasia	12.1%
192	Neurogenic Inflammation	12.1%
193	Gait Disorders, Neurologic	12.1%
194	Neuromuscular Manifestations	12.1%
195	Malformations of Cortical Development	12.1%
196	Chorea	12%
197	Cerebellar Neoplasms	12%
198	Alstrom Syndrome	12%
199	Lupus Vasculitis, Central Nervous System	11.8%
200	Refsum Disease	11.8%
201	Polymyositis	11.8%
202	Akathisia, Drug-Induced	11.7%
203	Myoclonic Epilepsy	11.6%
204	Epilepsy, Temporal Lobe	11.6%
205	Epilepsy, Rolandic	11.6%
206	Benign Rolandic Epilepsy	11.6%
207	Akinetic Mutism	11.4%
208	Anoxic Encephalopathy	11.4%
209	Arachnoiditis	11.4%
210	Basal Ganglia Diseases	11.4%
211	Brain Damage, Chronic	11.4%
212	Cerebellar Diseases	11.4%
213	Encephalitis	11.4%
214	Encephalomalacia	11.4%
215	Epilepsy	11.4%
216	Hydrocephalus	11.4%
217	Congenital Hydrocephalus	11.4%
218	Hypothalamic Diseases	11.4%
219	Aseptic Meningitis	11.4%
220	Syringomyelia	11.4%
221	Thalamic Diseases	11.4%
222	Intracranial Hypertension	11.4%
223	Aura	11.4%
224	Leukoencephalopathy	11.4%
225	Essential Tremor	11.4%
226	Neuroaxonal Dystrophies	11.4%
227	Familial Tremor	11.4%
228	Headache Disorders	11.4%
229	Intracranial Hypotension	11.4%
230	Brain Edema	11.4%
231	Brain Hypoxia	11.4%
232	Aqueductal Stenosis	11.4%
233	Pneumorrhachis	11.4%
234	Writer's Cramp	11.4%
235	Brain Abscess	11.3%
236	Ophthalmoplegia	11.3%
237	External Ophthalmoplegia	11.3%
238	Dementia, Vascular	11.1%
239	Brain Hemorrhage, Traumatic	11%
240	Brain Death	11%
241	Coma, Post-Head Injury	11%
242	Canavan Disease	11%
243	Alexander Disease	11%
244	Friedreich Ataxia	10.8%
245	Juvenile Myoclonic Epilepsy	10.7%
246	Myoclonic Epilepsies, Progressive	10.7%
247	Creutzfeldt-Jakob disease	10.7%
248	Basal Ganglia Cerebrovascular Disease	10.7%
249	Vasculitis, Central Nervous System	10.6%
250	Brain Injuries, Diffuse	10.6%
251	Traumatic Brain Injury	10.6%
252	Jet Lag Syndrome	10.6%
253	Cerebellar Ataxia	10.6%
254	Supratentorial Neoplasms	10.6%
255	Torticollis	10.6%
256	Multiple Sclerosis, Chronic Progressive	10.6%
257	Multiple Sclerosis, Relapsing-Remitting	10.6%
258	Mitochondrial Encephalomyopathies	10.4%
259	Complex Regional Pain Syndromes	10.3%
260	Tuberculosis, Meningeal	10.2%
261	Ataxia Telangiectasia	10.2%
262	Familial Periodic Paralysis	10.1%
263	Amblyopia	10.1%
264	Pupil Disorders	10%
265	Paraneoplastic Cerebellar Degeneration	10%
266	Neurobehavioral Manifestations	10%
267	Vascular Headaches	10%
268	Cerebrospinal Fluid Otorrhea	9.9%
269	Cerebrospinal Fluid Rhinorrhea	9.9%
270	Tuberous Sclerosis	9.9%
271	Gait Ataxia	9.9%
272	Hypoxia-Ischemia, Brain	9.9%
273	Carotid Artery Injuries	9.9%
274	Tardive Dyskinesia	9.9%
275	Persistent Vegetative State	9.9%
276	Vocal Cord Paralysis	9.8%
277	Paraneoplastic Encephalomyelitis	9.7%
278	Uveomeningoencephalitic Syndrome	9.6%
279	Muscular Dystrophy	9.5%
280	Sturge-Weber Syndrome	9.5%
281	Vertigo	9.5%
282	Alcohol-Induced Disorders, Nervous System	9.5%
283	Orbital Myositis	9.5%
284	Pyomyositis	9.4%
285	Peripheral Nervous System Diseases	9.3%
286	Alice in Wonderland Syndrome	9.2%
287	Diffuse Axonal Injury	9.2%
288	Brain Stem Neoplasms	9.2%
289	Brain Concussion	9%
290	Cerebral Palsy	9%
291	Epilepsies, Partial	9%
292	Epilepsy, Generalized	9%
293	Pseudotumor Cerebri	9%
294	Hypertensive Encephalopathy	9%
295	Simple Partial Seizures	9%
296	Epilepsy, Reflex	9%
297	Headache Disorders, Primary	9%
298	Headache Disorders, Secondary	9%
299	Medication overuse headache	9%
300	Pituitary Adenoma	8.9%
301	Pituitary Neoplasms	8.9%
302	Hepatolenticular Degeneration	8.9%
303	Leukomalacia, Periventricular	8.9%
304	Brain Diseases, Metabolic	8.6%
305	Cerebrovascular Disorders	8.6%
306	Optic Atrophy	8.6%
307	Optic Neuritis	8.6%
308	Papilledema	8.6%
309	Strabismus	8.6%
310	Tolosa-Hunt Syndrome	8.6%
311	Cerebrovascular Insufficiency	8.6%
312	Arsenic Poisoning	8.6%
313	Dementia	8.6%
314	Central Nervous System Fungal Infections	8.6%
315	Conus Medullaris Syndrome	8.6%
316	Spinal Cord Vascular Diseases	8.6%
317	Myalgia	8.6%
318	Akathisia	8.5%
319	Restlessness	8.5%
320	Psychomotor Agitation	8.5%
321	Choroid Plexus Papilloma	8.5%
322	Facial Injuries	8.5%
323	Facial Neuralgia	8.5%
324	Sleep Talking	8.5%
325	Manganese Poisoning	8.5%
326	Sleep Disorders, Intrinsic	8.5%
327	Anosmia	8.4%
328	Ataxia	8.4%
329	Athetosis	8.4%
330	Catalepsy	8.4%
331	Dystonia	8.4%
332	Hemiplegia	8.4%
333	Locked-In Syndrome	8.4%
334	Meningeal Neoplasms	8.4%
335	Meningomyelocele	8.4%
336	Muscle Hypertonia	8.4%
337	Muscle hypotonia	8.4%
338	Myoclonus	8.4%
339	Myotonia	8.4%
340	Paraplegia	8.4%
341	Pseudobulbar Palsy	8.4%
342	Quadriplegia	8.4%
343	Spasm	8.4%
344	Spastic Paraplegia	8.4%
345	Status Epilepticus	8.4%
346	Taste Disorders	8.4%
347	Tremor	8.4%
348	Spina Bifida	8.4%
349	Monoplegia	8.4%
350	Hypokinesia	8.4%
351	Paraparesis	8.4%
352	Bradykinesia	8.4%
353	Waxy flexibility	8.4%
354	Action Tremor	8.4%
355	Resting Tremor	8.4%
356	Dysosmia	8.4%
357	Quadriparesis	8.4%
358	Mercury Poisoning, Nervous System	8.4%
359	Olfaction Disorders	8.4%
360	Myokymia	8.4%
361	Lead Poisoning, Nervous System	8.4%
362	Vestibular Neuronitis	8.4%
363	Somatosensory Disorders	8.4%
364	Hyperkinesia	8.4%
365	Intention tremor	8.4%
366	Toxoplasmosis, Cerebral	8.4%
367	Optic Nerve Glioma	8.4%
368	Basal Ganglia Hemorrhage	8.3%
369	Alcohol Withdrawal Seizures	8.3%
370	Meningitis, Cryptococcal	8.3%
371	Meningitis, Listeria	8.2%
372	Meningitis, Haemophilus	8.2%
373	Meningitis, Pneumococcal	8.2%
374	Frontotemporal dementia	8.2%
375	Voice Disorders	8.1%
376	Voice Disturbance	8.1%
377	Vertebral Artery Dissection	8%
378	Amnesia, Transient Global	8%
379	Welander Distal Myopathy	8%
380	Gait Apraxia	8%
381	Smith-Magenis syndrome	8%
382	Dural Arteriovenous Fistula	7.9%
383	Post-Traumatic Headache	7.8%
384	Tension Headache	7.8%
385	Epilepsy, Complex Partial	7.8%
386	Migraine Disorders	7.8%
387	Abdominal Migraine	7.8%
388	Status Migrainosus	7.8%
389	Cervicogenic Headache	7.8%
390	Pituitary Apoplexy	7.8%
391	Putaminal Hemorrhage	7.8%
392	Hypokalemic periodic paralysis	7.7%
393	Brain Contusion	7.7%
394	MELAS Syndrome	7.7%
395	Brain Infarction	7.7%
396	Infarction, Middle Cerebral Artery	7.6%
397	Infarction, Anterior Cerebral Artery	7.6%
398	Infarction, Posterior Cerebral Artery	7.6%
399	Subacute Sclerosing Panencephalitis	7.6%
400	Subarachnoid Hemorrhage, Traumatic	7.6%
401	Carotid Artery, Internal, Dissection	7.6%
402	Reflex Sympathetic Dystrophy	7.6%
403	Cluster Headache	7.2%
404	Migraine with Aura	7.2%
405	Familial Hemiplegic Migraine	7.2%
406	Chronic Paroxysmal Hemicrania	7.2%
407	SUNCT Syndrome	7.2%
408	Paroxysmal Hemicrania	7.2%
409	Pituitary Diseases	7.1%
410	Cerebral Infarction	7%
411	Brain Stem Infarctions	7%
412	Kearns-Sayre syndrome	7%
413	Vision Disorders	7%
414	Metamorphopsia	7%
415	Visual Impairment	7%
416	Classical Lissencephalies and Subcortical Band Heterotopias	7%
417	Optic Neuropathy, Ischemic	6.9%
418	Anterior Ischemic Optic Neuropathy	6.9%
419	Central Nervous System Bacterial Infections	6.9%
420	Facial Hemiatrophy	6.8%
421	Melkersson-Rosenthal Syndrome	6.8%
422	Anisocoria	6.8%
423	Confusion	6.8%
424	Facial paralysis	6.8%
425	Lethargy	6.8%
426	Memory Disorders	6.8%
427	Muscle Cramp	6.8%
428	Perceptual Disorders	6.8%
429	Psychomotor Disorders	6.8%
430	Tonic Pupil	6.8%
431	Anhedonia	6.8%
432	Disorientation	6.8%
433	Facial Paresis	6.8%
434	Memory Loss	6.8%
435	Hemisensory Neglect	6.8%
436	Dysacusis	6.8%
437	Dermatomyositis	6.8%
438	Sleep Bruxism	6.8%
439	Lateral Medullary Syndrome	6.7%
440	Adrenoleukodystrophy	6.7%
441	Carotid Artery Diseases	6.7%
442	Brain Ischemia	6.7%
443	Esotropia	6.7%
444	Exotropia	6.7%
445	Sleep Apnea Syndromes	6.7%
446	Cerebrovascular accident	6.7%
447	Kluver-Bucy Syndrome	6.7%
448	Vasospasm, Intracranial	6.7%
449	Spinal Cord Ischemia	6.7%
450	Intracranial Arterial Diseases	6.7%
451	Anencephaly	6.7%
452	Meningocele	6.7%
453	Muscular Atrophy	6.7%
454	Respiratory Paralysis	6.7%
455	Encephalocele	6.7%
456	Reflex, Abnormal	6.7%
457	Hyporeflexia	6.7%
458	Hyperreflexia	6.7%
459	Disorders of Excessive Somnolence	6.7%
460	Sleep Initiation and Maintenance Disorders	6.7%
461	Night Terrors	6.7%
462	Somnambulism	6.7%
463	Tetany	6.7%
464	Trigeminal Nerve Disorder	6.7%
465	Transient Insomnia	6.7%
466	Sleep Paralysis	6.7%
467	Chronic Insomnia	6.7%
468	REM Sleep Behavior Disorder	6.7%
469	Hypersomnia	6.7%
470	Muscular Dystrophy, Duchenne	6.6%
471	Dermal Sinus	6.6%
472	Dysgeusia	6.6%
473	Formication	6.6%
474	Hyperalgesia	6.6%
475	Hyperesthesia	6.6%
476	Hypesthesia	6.6%
477	Language Disorders	6.6%
478	Numbness	6.6%
479	Paresthesia	6.6%
480	Paraparesis, Spastic	6.6%
481	Spina Bifida Cystica	6.6%
482	Trismus	6.6%
483	Spina Bifida Occulta	6.6%
484	Epilepsia Partialis Continua	6.6%
485	Hypogeusia	6.6%
486	Meningeal Carcinomatosis	6.6%
487	Brown-Sequard Syndrome	6.6%
488	Lissencephaly	6.6%
489	Polymicrogyria	6.6%
490	Pachygyria	6.6%
491	Schizencephaly	6.6%
492	Lockjaw	6.6%
493	Allodynia	6.6%
494	Lead Poisoning, Nervous System, Childhood	6.6%
495	Lead Poisoning, Nervous System, Adult	6.6%
496	Periventricular Nodular Heterotopia	6.6%
497	Ageusia	6.6%
498	Tuberculosis, Central Nervous System	6.6%
499	Auditory Perceptual Disorders	6.6%
500	Alexia	6.5%
501	Dyslexia	6.5%
502	Moyamoya Disease	6.3%
503	West Nile Fever	6.3%
504	Giant Cell Arteritis	6.2%
505	Temporal Arteritis	6.2%
506	Acoustic Neuroma	6%
507	Empty Sella Syndrome	6%
508	Hyperpituitarism	6%
509	Hypopituitarism	6%
510	Hypophysitis	6%
511	Hematoma, Subdural	5.9%
512	Hematoma, Epidural, Cranial	5.9%
513	Cerebral Arterial Diseases	5.8%
514	Vertebrobasilar Insufficiency	5.8%
515	Anterior Spinal Artery Syndrome	5.8%
516	Basilar Artery Stenosis	5.8%
517	Vertebral Artery Stenosis	5.8%
518	Sleep Apnea, Obstructive	5.8%
519	Sleep Apnea, Central	5.8%
520	Intracranial Hemorrhage, Hypertensive	5.8%
521	Transient Cerebral Ischemia	5.8%
522	Narcolepsy	5.8%
523	Trigeminal Neuralgia	5.8%
524	Kleine-Levin Syndrome	5.8%
525	Agraphia	5.8%
526	Anomia	5.8%
527	Cluttering	5.8%
528	Language Development Disorders	5.8%
529	Speech Disorders	5.8%
530	Syncope	5.8%
531	Stupor	5.8%
532	Dysgraphia	5.8%
533	Presyncope	5.8%
534	Dyslalia	5.8%
535	Duane Retraction Syndrome	5.7%
536	Consciousness Disorders	5.7%
537	Mental Retardation	5.7%
538	Muscle Weakness	5.7%
539	Depressed Level of Consciousness	5.7%
540	Mental deficiency	5.7%
541	Intellectual Disability	5.7%
542	Mobius Syndrome	5.7%
543	Bell Palsy	5.7%
544	Catatonia	5.6%
545	Herpes Zoster Oticus	5.6%
546	Aphonia	5.6%
547	Sleep Deprivation	5.6%
548	Dysphonia	5.6%
549	Eye Injuries	5.6%
550	Optic Atrophy, Hereditary, Leber	5.5%
551	Congenital nystagmus	5.4%
552	Hyperprolactinemia	5.4%
553	Diplopia	5.4%
554	Muscle Rigidity	5.4%
555	Muscle Spasticity	5.4%
556	Scotoma	5.4%
557	Photophobia	5.4%
558	Cogwheel Rigidity	5.4%
559	Hemifacial Spasm	5.4%
560	Amaurosis	5.4%
561	Blindness	5.4%
562	Nuchal Rigidity	5.4%
563	Reye Syndrome	5.4%
564	Neuroaspergillosis	5.4%
565	Subclavian Steal Syndrome	5.4%
566	Pick Disease of the Brain	5.4%
567	Hematoma, Subdural, Intracranial	5.4%
568	Hematoma, Subdural, Chronic	5.4%
569	Hematoma, Subdural, Acute	5.4%
570	Cataplexy	5.3%
571	Aphasia	5.3%
572	Articulation Disorders	5.3%
573	Echolalia	5.3%
574	Stuttering	5.3%
575	Dysphasia	5.3%
576	Intracranial Embolism and Thrombosis	5.3%
577	Hepatic Encephalopathy	5.3%
578	Agnosia	5.3%
579	Apraxias	5.3%
580	Hallucinations	5.3%
581	Hemianopsia	5.3%
582	Hyperacusis	5.3%
583	Tinnitus	5.3%
584	Visual Agnosia	5.3%
585	Anosognosia	5.3%
586	Wernicke-Korsakoff Syndrome	5.3%
587	Phonophobia	5.3%
588	Hearing Loss	5.3%
589	Sarcopenia	5.3%
590	Dysarthria	5.1%
591	Neuronal Ceroid-Lipofuscinoses	4.7%
592	Toxoplasmosis, Congenital	4.7%
593	Eye Burns	4.7%
594	Malaria, Cerebral	4.7%
595	Pseudorabies	4.7%
596	Carotid Stenosis	4.7%
597	Intracranial Aneurysm	4.7%
598	Neurocysticercosis	4.6%
599	Amaurosis Fugax	4.6%
600	Blindness, Cortical	4.6%
601	Dyscalculia	4.6%
602	Intracranial Arteriosclerosis	4.6%
603	Cerebral Atherosclerosis	4.6%
604	Rett Syndrome	4.6%
605	Subarachnoid Hemorrhage	4.6%
606	Cerebral Arteriosclerosis	4.6%
607	Cerebral Hemorrhage	4.6%
608	Cerebral Thrombosis	4.6%
609	Intracranial Embolism	4.6%
610	Intracranial Thrombosis	4.6%
611	Deafness	4.6%
612	Hearing Loss, Sudden	4.6%
613	Gerstmann Syndrome	4.6%
614	Hearing Loss, Bilateral	4.6%
615	Hearing Loss, High-Frequency	4.6%
616	Hearing Loss, Mixed Conductive-Sensorineural	4.6%
617	Prosopagnosia	4.6%
618	Apraxia, Ideomotor	4.6%
619	Charles Bonnet Syndrome	4.6%
620	Hearing Loss, Unilateral	4.6%
621	Complete Hearing Loss	4.6%
622	Alien Hand Syndrome	4.6%
623	Deaf Mutism	4.6%
624	Amnesia	4.5%
625	Delirium	4.5%
626	Dissociative Amnesia	4.5%
627	Color blindness	4.5%
628	Global Amnesia	4.5%
629	Cri-du-Chat Syndrome	4.5%
630	Down Syndrome	4.5%
631	Brain Diseases, Metabolic, Inborn	4.5%
632	Trisomy 21	4.5%
633	Meningioma	4.4%
634	Williams Syndrome	4.4%
635	Microcephaly	4.4%
636	Macrocephaly	4.4%
637	Neurosyphilis	4.4%
638	Porencephaly	4.4%
639	Mutism	4.3%
640	Selective Mutism	4.3%
641	Acromegaly	4.3%
642	Cerebral Amyloid Angiopathy	4.3%
643	Aicardi's syndrome	4.3%
644	Sinus Thrombosis, Intracranial	4.2%
645	Hoarseness	4.2%
646	Cockayne Syndrome	4.2%
647	Alcohol Withdrawal Delirium	4.2%
648	Alexia, Pure	4.1%
649	Cavernous Sinus Thrombosis	4.1%
650	Sagittal Sinus Thrombosis	4.1%
651	Waterhouse-Friderichsen Syndrome	4%
652	Corneal Scar	4%
653	Retrograde amnesia	3.8%
654	Amnesia, Anterograde	3.8%
655	Carotid Artery Thrombosis	3.8%
656	Prader-Willi Syndrome	3.8%
657	Menkes Kinky Hair Syndrome	3.8%
658	Wernicke Encephalopathy	3.8%
659	AIDS Dementia Complex	3.8%
660	Phantom pain	3.8%
661	Phantom Limb Pain	3.8%
662	Lyme Neuroborreliosis	3.7%
663	Holoprosencephaly	3.7%
664	Corneal Perforation	3.6%
665	Nelson Syndrome	3.4%
666	Kernicterus	3.4%
667	Fragile X Syndrome	3.3%
668	Prolactinoma	3.1%
669	Growth Hormone-Secreting Pituitary Adenoma	3.1%
670	Fabry Disease	3%
671	Rubinstein-Taybi Syndrome	3%
672	Galactosemias	2.9%
673	Urea Cycle Disorders, Inborn	2.9%
674	Tyrosinemias	2.9%
675	Homocystinuria	2.6%
676	Leigh Disease	2.5%
677	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.3%
678	Mucopolysaccharidosis II	2.3%
679	Glycogen storage disease type II	2.1%
680	Zellweger Syndrome	1.9%
681	Gaucher Disease	1.8%
682	Tay-Sachs Disease	1.8%
683	Niemann-Pick Disease, Type C	1.6%

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