MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyaline Membrane Disease

(UMLS:C0020192)

Definition:: A respiratory distress syndrome in newborn infants, usually premature infants with insufficient PULMONARY SURFACTANTS. The disease is characterized by the formation of a HYALINE-like membrane lining the terminal respiratory airspaces (PULMONARY ALVEOLI) and subsequent collapse of the lung (PULMONARY ATELECTASIS).
UMLS ID:: C0020192
MeSH ID:: D006819

Classification 1:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.842.475|C08.618.842.475

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.614.521.563.475

Synonym(s)

Hyaline Membrane Disease

HMD - Hyaline membrane disease

HYALINE MEMBRANE DISEASE

Hyaline membrane disease

distress newborn respiratory

distress newborns respiratory

hyaline membrane disease

newborn rds

newborn respiratory distress

10.

newborns rds

11.

respiratory distress newborn

12.

respiratory distress of newborn

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Morphine		7669374	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Respiratory Distress Syndrome, Adult	32.7%
2	Meconium Aspiration Syndrome	25.5%
3	Pneumonia	24.5%
4	Lobar Pneumonia	24.5%
5	Pneumonitis	24.5%
6	Bronchitis	22.6%
7	Bronchopulmonary Dysplasia	21.7%
8	Cystic Fibrosis	21.7%
9	Persistent Fetal Circulation Syndrome	20.8%
10	Lung Diseases, Fungal	20.6%
11	Vocal Cord Dysfunction	20.6%
12	Lung Abscess	20.2%
13	Lung Neoplasms	20.2%
14	Altitude Sickness	20.2%
15	Atelectasis	20.2%
16	Pulmonary Hypertension	20.2%
17	Pulmonary Alveolar Proteinosis	20.2%
18	Pulmonary Edema	20.2%
19	Pulmonary Fibrosis	20.2%
20	Respiratory Insufficiency	20.2%
21	Hamman-Rich syndrome	20.2%
22	Lung Diseases, Interstitial	20.2%
23	Respiratory Depression	20.2%
24	Lung Diseases, Obstructive	20.2%
25	Respiratory Failure	20.2%
26	Tuberculosis, Pulmonary	20.1%
27	Bronchopneumonia	20.1%
28	Asthma	19.2%
29	Acute Chest Syndrome	19.1%
30	Tracheobronchomegaly	19%
31	Pleuropneumonia	19%
32	Bronchitis, Chronic	18.8%
33	Idiopathic Pulmonary Fibrosis	18.4%
34	Pneumoconiosis	18.3%
35	Bronchial Diseases	17.4%
36	Pleural Diseases	17.4%
37	Thoracic Diseases	17.4%
38	Tracheal Diseases	17.4%
39	Granuloma, Laryngeal	16.9%
40	Pleurisy	16.3%
41	Tracheitis	16.3%
42	Lung Injury	16.3%
43	Hepatopulmonary Syndrome	16.3%
44	Respiratory Aspiration	16.3%
45	Apnea	16.1%
46	Cheyne-Stokes Respiration	16.1%
47	Dyspnea	16.1%
48	Hyperventilation	16.1%
49	Mouth Breathing	16.1%
50	Tachypnea	16.1%
51	Pulmonary Embolism	16%
52	Pulmonary Eosinophilia	15.9%
53	Eosinophilic Pneumonia	15.9%
54	Aspiration Pneumonia	15.9%
55	Scimitar Syndrome	15.4%
56	Bronchiolitis	15.4%
57	Radiation Pneumonitis	15.2%
58	Radiation Fibrosis	15.2%
59	Laryngeal Diseases	14.4%
60	Nose Diseases	14.4%
61	Retinopathy of Prematurity	14.1%
62	Respiratory Tract Infections	14%
63	Granuloma, Respiratory Tract	13.8%
64	Respiratory Hypersensitivity	13.8%
65	Respiratory Tract Fistula	13.8%
66	Laryngitis	13.7%
67	Pneumonia, Viral	13.7%
68	Rhinitis	13.7%
69	Bronchial Fistula	13.5%
70	Pleural Neoplasms	13.5%
71	Pneumonia, Bacterial	13.4%
72	Hemoptysis	13.4%
73	Asbestosis	13.3%
74	Berylliosis	13.3%
75	Laryngospasm	13.3%
76	Silicosis	13.3%
77	Airway Obstruction	13.2%
78	Aspergillosis, Allergic Bronchopulmonary	13.2%
79	Choking	13.2%
80	Chronic Obstructive Airway Disease	13.2%
81	Middle Lobe Syndrome	13.2%
82	Acute Lung Injury	13.2%
83	Choanal Atresia	13.2%
84	Laryngocele	13.2%
85	Multiple Pulmonary Nodules	13.2%
86	Abdominal Cramps	12.6%
87	Amniotic Band Syndrome	12.6%
88	Asphyxia Neonatorum	12.6%
89	Infantile Colic	12.6%
90	Primary Ciliary Dyskinesia	12.5%
91	Hoarseness	11.9%
92	Pneumonia, Lipid	11.8%
93	Tracheal Neoplasms	11.5%
94	Pleural Effusion, Malignant	11.3%
95	Sinusitis	11.2%
96	Bronchial Neoplasms	11.1%
97	Histiocytosis, Langerhans-Cell	10.6%
98	Pulmonary Aspergillosis	10.6%
99	Bronchopulmonary Aspergillosis	10.6%
100	Hypoventilation	10.6%
101	Acidosis, Respiratory	10.5%
102	Alkalosis, Respiratory	10.5%
103	Sarcoidosis, Pulmonary	10.5%
104	Sleep Apnea Syndromes	10.5%
105	Pulmonary Infarction	10.5%
106	Kartagener Syndrome	10.4%
107	Bronchiolitis Obliterans	10.4%
108	Laryngeal neoplasm	10.3%
109	Bronchospasm	10.1%
110	Bronchiectasis	10.1%
111	Chylothorax	10.1%
112	Hydropneumothorax	10.1%
113	Hydrothorax	10.1%
114	Pneumothorax	10.1%
115	Tracheal Stenosis	10.1%
116	Bronchial Hyperreactivity	10.1%
117	Anemia, Neonatal	10.1%
118	Umbilical hernia	10%
119	Leukomalacia, Periventricular	9.9%
120	Pulmonary Emphysema	9.8%
121	Farmer's Lung	9.5%
122	Blastomycosis	8.8%
123	Dyspnea, Paroxysmal	8.8%
124	Respiratory Paralysis	8.8%
125	Asthma, Exercise-Induced	8.8%
126	Status Asthmaticus	8.8%
127	Granulomatosis with polyangiitis	8.8%
128	Lung diseases	8.7%
129	Respiration Disorders	8.7%
130	Xeroderma	8.6%
131	Mobius Syndrome	8.6%
132	Neonatal Abstinence Syndrome	8.6%
133	Laryngostenosis	8.5%
134	Congenital nystagmus	8.3%
135	Toxoplasmosis, Congenital	8.3%
136	Syphilis, Congenital	8.2%
137	Granuloma, Lethal Midline	8.2%
138	Laryngeal Edema	8.2%
139	Nose Deformities, Acquired	8.2%
140	Nose Neoplasms	8.1%
141	Common Cold	8.1%
142	Hemothorax	8.1%
143	Influenza	8.1%
144	Catarrh	8.1%
145	Rhinoscleroma	8%
146	Severe Acute Respiratory Syndrome	8%
147	Laryngopharyngeal Reflux	8%
148	Paranasal Sinus Neoplasms	7.9%
149	Deformity	7.8%
150	Genetic Diseases, Inborn	7.8%
151	Sleep Apnea, Obstructive	7.8%
152	Sleep Apnea, Central	7.8%
153	Asthma, Occupational	7.7%
154	Anti-Glomerular Basement Membrane Disease	7.5%
155	Congenital Hyperinsulinism	7.2%
156	Pharyngitis	6.9%
157	Nasal Polyps	6.8%
158	Respiratory Distress Syndrome, Newborn	6.8%
159	Pertussis	6.7%
160	Transfusion-Related Acute Lung Injury	6.7%
161	Asthma, Aspirin-Induced	6.6%
162	Epiglottitis	6.6%
163	Mediastinitis	6.6%
164	Invasive Pulmonary Aspergillosis	6.6%
165	Hay fever	6.5%
166	Rhinitis, Allergic, Perennial	6.5%
167	Laryngomalacia	6.4%
168	Fetal Diseases	6.3%
169	Paralysis, Obstetric	6%
170	Voice Disorders	5.9%
171	Voice Disturbance	5.9%
172	Maxillary Sinus Neoplasms	5.8%
173	Epistaxis	5.8%
174	Ophthalmia Neonatorum	5.5%
175	Mediastinal Cyst	5.4%
176	Pericardial Cyst	5.4%
177	Thymic Cyst	5.4%
178	Croup	5.3%
179	Mediastinal Emphysema	5.3%
180	Rhinitis, Vasomotor	5.3%
181	Ichthyosis, X-Linked	5.2%
182	Vocal Cord Paralysis	5%
183	Beckwith-Wiedemann Syndrome	5%
184	Wolf-Hirschhorn Syndrome	5%
185	Eosinophilic Granuloma	5%
186	Aicardi's syndrome	4.9%
187	Bronchomalacia	4.7%
188	Tracheomalacia	4.7%
189	CHARGE Syndrome	4.5%
190	Tonsillitis	4.4%
191	Hyaline Membrane Disease	4.4%
192	Smith-Magenis syndrome	4.3%
193	Holoprosencephaly	4.3%
194	Cri-du-Chat Syndrome	4.2%
195	Down Syndrome	4.2%
196	Trisomy 21	4.2%
197	Sjogren-Larsson Syndrome	4.2%
198	Nesidioblastosis	4.2%
199	Abnormalities, Drug-Induced	4.2%
200	Situs Inversus	4.2%
201	Nail-Patella Syndrome	3.9%
202	Aphonia	3.8%
203	Retropharyngeal Abscess	3.8%
204	Dysphonia	3.8%
205	Ectodermal Dysplasia	3.7%
206	Aplasia Cutis Congenita	3.7%
207	Prader-Willi Syndrome	3.7%
208	Rubinstein-Taybi Syndrome	3.6%
209	Eye Abnormalities	3.5%
210	Neoplastic Syndromes, Hereditary	3.5%
211	Cardiovascular Abnormalities	3.5%
212	Hyperkeratosis, Epidermolytic	3.4%
213	Skin Abnormalities	3.4%
214	Lymphatic Abnormalities	3.4%
215	Congenital Microtia	3.4%
216	Marfan Syndrome	3.4%
217	Multiple Epiphyseal Dysplasia	3.4%
218	Osteochondrodysplasias	3.4%
219	Pelger-Huet Anomaly	3.4%
220	Werner Syndrome	3.4%
221	Myasthenic Syndromes, Congenital	3.4%
222	Kernicterus	3.3%
223	Congenital diaphragmatic hernia	3.3%
224	Nasopharyngitis	3.3%
225	Cockayne Syndrome	3.3%
226	Fragile X Syndrome	3.2%
227	Alstrom Syndrome	3%
228	Urogenital Abnormalities	2.9%
229	Dwarfism	2.9%
230	Anemia, Sickle Cell	2.8%
231	Thalassemia	2.8%
232	Muscular Dystrophy, Duchenne	2.8%
233	Polycystic Kidney Diseases	2.8%
234	Williams Syndrome	2.8%
235	Fetal Growth Retardation	2.8%
236	Peritonsillar Abscess	2.8%
237	Muscular Dystrophy	2.8%
238	Osteogenesis Imperfecta	2.8%
239	Fetal Hypoxia	2.8%
240	Fetal Alcohol Spectrum Disorders	2.8%
241	Anencephaly	2.7%
242	Albinism	2.6%
243	Retinal Dysplasia	2.6%
244	Smith-Lemli-Opitz Syndrome	2.5%
245	Aniridia	2.5%
246	Epidermolysis Bullosa	2.5%
247	Familial Mediterranean Fever	2.5%
248	Prune Belly Syndrome	2.5%
249	Twins, Conjoined	2.5%
250	Waardenburg Syndrome	2.5%
251	Autoimmune Lymphoproliferative Syndrome	2.4%
252	Chorioamnionitis	2.4%
253	Maxillofacial Abnormalities	2.4%
254	Dural Arteriovenous Fistula	2.4%
255	Kallmann Syndrome	2.4%
256	Dextrocardia	2.4%
257	Angioedemas, Hereditary	2.4%
258	Wiskott-Aldrich Syndrome	2.2%
259	Rett Syndrome	2.2%
260	Tuberous Sclerosis	2.1%
261	Abnormalities, Radiation-Induced	2.1%
262	Mucopolysaccharidosis II	2%
263	Anophthalmos	2%
264	Anus, Imperforate	2%
265	Hydranencephaly	2%
266	Microphthalmos	2%
267	Neural Tube Defects	2%
268	Tethered Cord Syndrome	2%
269	Iniencephaly	2%
270	Craniorachischisis	2%
271	Limb Deformities, Congenital	2%
272	Exencephaly	2%
273	Septo-Optic Dysplasia	2%
274	Craniofacial Abnormalities	2%
275	Cortical Dysplasia	2%
276	Malformations of Cortical Development	2%
277	Anorectal Malformations	2%
278	Pseudoxanthoma Elasticum	2%
279	Menkes Kinky Hair Syndrome	2%
280	Amino Acid Metabolism, Inborn Errors	2%
281	Bloom Syndrome	2%
282	Carbohydrate Metabolism, Inborn Errors	2%
283	Metal Metabolism, Inborn Errors	2%
284	Progeria	2%
285	Lysosomal Storage Diseases	2%
286	Cytochrome-c Oxidase Deficiency	2%
287	Peroxisomal Disorders	2%
288	Myotonic Dystrophy	2%
289	Classical Lissencephalies and Subcortical Band Heterotopias	1.9%
290	Sickle Cell Trait	1.9%
291	Refsum Disease	1.9%
292	Polycystic Kidney, Autosomal Dominant	1.8%
293	Neuronal Ceroid-Lipofuscinoses	1.8%
294	Xeroderma Pigmentosum	1.8%
295	Zellweger Syndrome	1.8%
296	Blepharophimosis	1.7%
297	Mouth Abnormalities	1.7%
298	Cutis Laxa	1.7%
299	Esophageal Atresia	1.7%
300	Intestinal Atresia	1.7%
301	Horseshoe Kidney	1.7%
302	Pectus excavatum	1.7%
303	Ataxia Telangiectasia	1.7%
304	Klippel-Feil Syndrome	1.7%
305	Retinitis Pigmentosa	1.7%
306	Gastroschisis	1.7%
307	Synostosis	1.7%
308	Pigmentary retinopathy	1.7%
309	Acrodermatitis	1.7%
310	Lymphangiectasis, Intestinal	1.7%
311	Porokeratosis	1.7%
312	Gianotti-Crosti Syndrome	1.7%
313	Keratoderma, Palmoplantar	1.7%
314	Chronic granulomatous disease	1.6%
315	Basal Cell Nevus Syndrome	1.6%
316	Hepatolenticular Degeneration	1.6%
317	Craniosynostosis	1.6%
318	Syndactyly	1.6%
319	Brachycephaly	1.6%
320	Welander Distal Myopathy	1.6%
321	Microcephaly	1.6%
322	Macrocephaly	1.6%
323	Charcot-Marie-Tooth Disease	1.6%
324	Antley-Bixler Syndrome Phenotype	1.6%
325	Amyloid Neuropathies, Familial	1.6%
326	Turner Syndrome	1.6%
327	Adrenoleukodystrophy	1.6%
328	Hydrops Fetalis	1.5%
329	Acrocephalosyndactylia	1.5%
330	Noonan Syndrome	1.5%
331	Arthrogryposis	1.5%
332	Klinefelter Syndrome	1.5%
333	Choledochal Cyst	1.4%
334	Duane Retraction Syndrome	1.4%
335	Hermaphroditism	1.4%
336	Disorders of Sex Development	1.4%
337	Galactosemias	1.4%
338	Urea Cycle Disorders, Inborn	1.4%
339	Tyrosinemias	1.4%
340	Fabry Disease	1.4%
341	Cryptorchidism	1.4%
342	Porphyrias, Hepatic	1.4%
343	Hypospadias	1.4%
344	Central Nervous System Cysts	1.4%
345	Dandy-Walker Syndrome	1.4%
346	Peutz-Jeghers Syndrome	1.4%
347	Myotonia Congenita	1.4%
348	Thrombasthenia	1.4%
349	Antithrombin III Deficiency	1.4%
350	Protein C Deficiency	1.4%
351	Brain Diseases, Metabolic, Inborn	1.4%
352	Afibrinogenemia	1.4%
353	Dystonia Musculorum Deformans	1.4%
354	Factor VII Deficiency	1.4%
355	Factor X Deficiency	1.4%
356	Factor XII Deficiency	1.4%
357	Hemophilia A	1.4%
358	POEMS Syndrome	1.4%
359	Activated Protein C Resistance	1.4%
360	Factor II deficiency	1.4%
361	Factor VIII Deficiency	1.4%
362	Factor V deficiency	1.4%
363	Factor XI Deficiency	1.4%
364	Hypoprothrombinemias	1.4%
365	Fanconi Anemia	1.4%
366	Lafora Disease	1.4%
367	Unverricht-Lundborg Syndrome	1.4%
368	Anemia, Diamond-Blackfan	1.4%
369	Porencephaly	1.4%
370	Canavan Disease	1.3%
371	Alexander Disease	1.3%
372	Amelia	1.3%
373	Arachnodactyly	1.3%
374	Ectopia Cordis	1.3%
375	Ectromelia	1.3%
376	Hemimelia	1.3%
377	Meningomyelocele	1.3%
378	Phocomelia	1.3%
379	Sirenomelia	1.3%
380	Spina Bifida	1.3%
381	Polydactyly	1.3%
382	Brachydactyly	1.3%
383	Plagiocephaly	1.3%
384	Lower Extremity Deformities, Congenital	1.3%
385	Upper Extremity Deformities, Congenital	1.3%
386	Single umbilical artery	1.3%
387	Glycogen storage disease type II	1.3%
388	Alkaptonuria	1.3%
389	Glycogen Storage Disease	1.3%
390	Hypophosphatasia	1.3%
391	Propionic acidemia	1.3%
392	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
393	Cystinosis	1.3%
394	Optic Atrophy, Hereditary, Leber	1.3%
395	Hyperphosphaturia	1.3%
396	Jaw Abnormalities	1.3%
397	Cleft Palate	1.3%
398	Multiple Endocrine Neoplasia	1.3%
399	Pectus carinatum	1.3%
400	Bladder Exstrophy	1.3%
401	Congenital Hypothyroidism	1.3%
402	Epispadias	1.3%
403	Dermatitis, Atopic	1.2%
404	Multicystic Dysplastic Kidney	1.2%
405	Poland Syndrome	1.2%
406	Mucopolysaccharidosis III	1.2%
407	Homocystinuria	1.1%
408	Leigh Disease	1.1%
409	Behcet Syndrome	1.1%
410	Aortic coarctation	1.1%
411	Cor Triatriatum	1.1%
412	Coronary Vessel Anomalies	1.1%
413	Dental Enamel Hypoplasia	1.1%
414	Patent ductus arteriosus	1.1%
415	Ebstein Anomaly	1.1%
416	Heart Septal Defects	1.1%
417	Hypodontia	1.1%
418	Macrostomia	1.1%
419	Meningocele	1.1%
420	Microstomia	1.1%
421	Tetralogy of Fallot	1.1%
422	Transposition of Great Vessels	1.1%
423	Hypoplastic Left Heart Syndrome	1.1%
424	May-Thurner Syndrome	1.1%
425	Encephalocele	1.1%
426	Craniofacial Dysostosis	1.1%
427	Hypolipoproteinemias	1.1%
428	Papillon-Lefevre Disease	1.1%
429	Wolff-Parkinson-White Syndrome	1.1%
430	Hyperlipidemia, Familial Combined	1.1%
431	Hyperlipoproteinemia Type III	1.1%
432	Gaucher Disease	1%
433	Micrognathism	1%
434	Pierre Robin Syndrome	1%
435	Huntington Disease	1%
436	Dermal Sinus	1%
437	Spina Bifida Cystica	1%
438	Spina Bifida Occulta	1%
439	Lissencephaly	1%
440	Polymicrogyria	1%
441	Pachygyria	1%
442	Schizencephaly	1%
443	Periventricular Nodular Heterotopia	1%
444	Glycogen Storage Disease Type I	1%
445	Glycogen Storage Disease Type V	1%
446	Carbamoyl-Phosphate Synthase I Deficiency Disease	1%
447	Familial Periodic Paralysis	0.9%
448	Long QT Syndrome	0.9%
449	Platybasia	0.9%
450	Tricuspid Atresia	0.9%
451	Arrhythmogenic Right Ventricular Dysplasia	0.9%
452	Gonadal Dysgenesis	0.9%
453	Adrenogenital Syndrome	0.9%
454	Ovotesticular Disorders of Sex Development	0.9%
455	Lactose Intolerance	0.9%
456	Variegate Porphyria	0.9%
457	Acute intermittent porphyria	0.9%
458	Porphyria Cutanea Tarda	0.9%
459	Hyperhomocysteinemia	0.9%
460	Renal Aminoacidurias	0.9%
461	Fanconi Syndrome	0.9%
462	Pseudohypoaldosteronism	0.9%
463	Liddle Syndrome	0.9%
464	Hyperlipoproteinemia Type IV	0.9%
465	Hyperlipoproteinemia Type V	0.9%
466	Retrognathia	0.9%
467	Nephroblastoma	0.9%
468	Hyperandrogenism	0.9%
469	Tay-Sachs Disease	0.8%
470	Gout	0.8%
471	Niemann-Pick Disease, Type C	0.8%
472	Multiple Endocrine Neoplasia Type 1	0.8%
473	Pseudohypoparathyroidism	0.8%
474	Prognathism	0.8%
475	Friedreich Ataxia	0.8%
476	Aortopulmonary Septal Defect	0.8%
477	Double Outlet Right Ventricle	0.8%
478	Endocardial Cushion Defects	0.8%
479	Myocardial bridging	0.8%
480	Aorticopulmonary Septal Defect	0.8%
481	Adenomatous Polyposis Coli	0.8%
482	Renal tubular acidosis	0.8%
483	Hypoalphalipoproteinemias	0.8%
484	Denys-Drash Syndrome	0.8%
485	Hypokalemic periodic paralysis	0.7%
486	Mandibulofacial Dysostosis	0.7%
487	Romano-Ward Syndrome	0.7%
488	Cystinuria	0.7%
489	Truncus Arteriosus, Persistent	0.7%
490	Goldenhar Syndrome	0.7%
491	Glycosuria, Renal	0.6%
492	Familial Hypophosphatemic Rickets	0.6%
493	Arthritis, Gouty	0.6%
494	Talipes	0.6%
495	Arteriovenous fistula	0.5%
496	MELAS Syndrome	0.5%
497	Congenital clubfoot	0.5%
498	Vertical Talus	0.5%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234