MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Latent Autoimmune Diabetes in Adults

(UMLS:C1739108)

Definition:: Autoimmune diabetes in adults with slowly progressive PANCREATIC BETA CELL failure and the presence of circulating autoantibodies to PANCREATIC ISLETS cell antigens.
UMLS ID:: C1739108
MeSH ID:: D000071698

Classification 1:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.394.750.714

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.246.656

Classification 3:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.576

Synonym(s)

Latent Autoimmune Diabetes in Adults

Latent autoimmune diabetes in adults

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Metformin	FAERS: 9	US FAERS
2	Metformin	FAERS: 7	US FAERS
3	Diazepam	FAERS: 3	US FAERS
4	Aripiprazole	FAERS: 2	US FAERS
5	Canagliflozin	FAERS: 1	US FAERS
6	Exenatide	FAERS: 1	US FAERS
7	Isotretinoin	FAERS: 1	US FAERS
8	Lamivudine	FAERS: 1	US FAERS
9	Nateglinide		OFFSIDES
10	urinastatin		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Gestational Diabetes	31%
2	Diabetes Mellitus, Experimental	30.7%
3	Diabetic Ketoacidosis	29.2%
4	Antiphospholipid Syndrome	20.9%
5	Addison Disease	20.7%
6	Autoimmune thyroiditis	20.7%
7	Primary Adrenal Insufficiency	20.7%
8	Hyperglycemia	17.9%
9	Hyperinsulinism	17.9%
10	Hypoglycemia	17.9%
11	Graves Disease	17.6%
12	Lupus Erythematosus, Systemic	16.8%
13	Overlap syndrome	16.8%
14	Pemphigus	16.6%
15	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	16.4%
16	Autoimmune hepatitis	16.4%
17	Autoimmune Lymphoproliferative Syndrome	14.8%
18	Diabetic Foot	14.3%
19	Wasting Syndrome	14%
20	Dermatitis Herpetiformis	13.7%
21	Congenital Hyperinsulinism	13.7%
22	Acid-Base Imbalance	13%
23	Calcium Metabolism Disorders	13%
24	Iron Metabolism Disorders	13%
25	Phosphorus Metabolism Disorders	13%
26	Water-Electrolyte Imbalance	13%
27	Lipid Metabolism Disorders	13%
28	Mitochondrial Diseases	13%
29	Hyperglycemic Hyperosmolar Nonketotic Coma	12.7%
30	Diabetic Angiopathies	12.4%
31	Diabetic Neuropathies	12.2%
32	Hypercalcemia	12.2%
33	Hypocalcemia	12.2%
34	Milk-Alkali Syndrome	12.2%
35	Diabetic Amyotrophy	12.2%
36	Diabetic Autonomic Neuropathy	12.2%
37	Diabetic Cardiomyopathies	12.2%
38	Rheumatoid Arthritis	11.8%
39	Juvenile arthritis	11.8%
40	Glycosuria	11.8%
41	Anti-Glomerular Basement Membrane Disease	11.5%
42	Myasthenia Gravis, Autoimmune, Experimental	11.1%
43	Adrenal Gland Diseases	10.8%
44	Gonadal Disorders	10.8%
45	Hypersensitivity	10.8%
46	Immunologic Deficiency Syndromes	10.8%
47	Immunoproliferative Disorders	10.8%
48	Parathyroid Diseases	10.8%
49	Thyroid Diseases	10.8%
50	Immune reconstitution syndrome	10.8%
51	Immune Reconstitution Inflammatory Syndrome	10.8%
52	Autoimmune thrombocytopenia	10.7%
53	Immune thrombocytopenic purpura	10.7%
54	Osteopenia	10.5%
55	Brain Diseases, Metabolic	10.3%
56	Myasthenia Gravis	10.3%
57	Uveomeningoencephalitic Syndrome	10.3%
58	Lipodystrophy	10.2%
59	Diabetic Nephropathy	10.1%
60	Granulomatosis with polyangiitis	10.1%
61	Pseudohypoparathyroidism	10%
62	Nesidioblastosis	10%
63	Insulin Resistance	9.4%
64	Adrenal Gland Neoplasms	9.2%
65	Rickets	9.2%
66	Stiff-Person Syndrome	8.9%
67	Polyradiculoneuropathy	8.8%
68	Polyradiculoneuritis	8.8%
69	Primary amyloidosis	8.7%
70	Brain Diseases, Metabolic, Inborn	8.7%
71	Bone Diseases, Endocrine	8.6%
72	Endocrine Gland Neoplasms	8.6%
73	Transfusion Reaction	8.6%
74	Hypotensive Transfusion Reaction	8.6%
75	Felty Syndrome	8.6%
76	Neuromyelitis Optica	8.6%
77	Lupus Nephritis	8.6%
78	Diabetic Retinopathy	8.5%
79	Leukoencephalitis, Acute Hemorrhagic	8.5%
80	Pituitary Diseases	8.5%
81	Multiple Sclerosis	8.4%
82	Leigh Disease	8.4%
83	Nutrition Disorders	8.1%
84	Parathyroid Neoplasms	7.9%
85	Thyroid Neoplasm	7.9%
86	Thyroid carcinoma	7.9%
87	Lupus Vasculitis, Central Nervous System	7.7%
88	Hyperhomocysteinemia	7.7%
89	Acidosis	7.7%
90	Alkalosis	7.7%
91	Amyloidosis	7.7%
92	Calcinosis	7.7%
93	Hyperkalemia	7.7%
94	Hypernatremia	7.7%
95	Hypokalemia	7.7%
96	Hyponatremia	7.7%
97	Xanthomatosis	7.7%
98	Hypophosphatemia	7.7%
99	Metabolic acidosis	7.7%
100	Dyslipidemias	7.7%
101	Iron Overload	7.7%
102	Xanthoma	7.7%
103	Vasculitis, Central Nervous System	7.6%
104	HIV Wasting Syndrome	7.5%
105	Rheumatoid Vasculitis	7.5%
106	Multiple Sclerosis, Chronic Progressive	7.5%
107	Multiple Sclerosis, Relapsing-Remitting	7.5%
108	Carbamoyl-Phosphate Synthase I Deficiency Disease	7.3%
109	Encephalomyelitis, Acute Disseminated	7.2%
110	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	7.2%
111	Lactose Intolerance	7.1%
112	Neuritis, Autoimmune, Experimental	7.1%
113	Dwarfism	7.1%
114	Adrenal Cortex Diseases	7%
115	Euthyroid Sick Syndromes	7%
116	Goiter	7%
117	Hyperparathyroidism	7%
118	Hyperthyroidism	7%
119	Hyperthyroxinemia	7%
120	Hypogonadism	7%
121	Hypoparathyroidism	7%
122	Hypothyroidism	7%
123	Immune Complex Diseases	7%
124	Delayed Puberty	7%
125	Precocious Puberty	7%
126	Thyroiditis	7%
127	Hypogonadotropic hypogonadism	7%
128	Latex allergy	7%
129	Testotoxicosis	7%
130	Secondary hypothyroidism	7%
131	Primary Hyperthyroidism	7%
132	Primary Hypothyroidism	7%
133	Glomerulonephritis, Membranoproliferative	6.9%
134	Lambert-Eaton Myasthenic Syndrome	6.8%
135	Hypolipoproteinemias	6.7%
136	Sicca Syndrome	6.7%
137	Sjogren's Syndrome	6.7%
138	Smith-Lemli-Opitz Syndrome	6.6%
139	HIV-Associated Lipodystrophy Syndrome	6.6%
140	Galactosemias	6.6%
141	Urea Cycle Disorders, Inborn	6.6%
142	Tyrosinemias	6.6%
143	Glycosuria, Renal	6.6%
144	Kernicterus	6.4%
145	Hyperlipoproteinemia Type IV	6.4%
146	Hyperlipoproteinemia Type V	6.4%
147	Guillain-Barre Syndrome	6.3%
148	Mitochondrial Encephalomyopathies	6.2%
149	Dehydration	6.2%
150	Lipomatosis	6.2%
151	Water Intoxication	6.2%
152	Werner Syndrome	6.2%
153	Osteomalacia	6.2%
154	Adrenocortical carcinoma	6.2%
155	Achlorhydria	6.1%
156	Amino Acid Metabolism, Inborn Errors	6.1%
157	Bloom Syndrome	6.1%
158	Carbohydrate Metabolism, Inborn Errors	6.1%
159	Metal Metabolism, Inborn Errors	6.1%
160	Osteoporosis	6.1%
161	Progeria	6.1%
162	Lysosomal Storage Diseases	6.1%
163	Bone Demineralization, Pathologic	6.1%
164	Cytochrome-c Oxidase Deficiency	6.1%
165	Peroxisomal Disorders	6.1%
166	Post-Traumatic Osteoporosis	6.1%
167	Celiac Disease	6.1%
168	Sprue, Tropical	6.1%
169	Steatorrhea	6.1%
170	Sprue	6.1%
171	Familial Hypophosphatemic Rickets	6%
172	Renal Osteodystrophy	6%
173	Renal rickets	6%
174	Congenital Hypothyroidism	5.9%
175	Hyperphosphaturia	5.9%
176	ovarian neoplasm	5.9%
177	Hyperlipidemia, Familial Combined	5.8%
178	Ataxia Telangiectasia	5.8%
179	Environmental Illness	5.8%
180	Monoclonal Gammopathy of Undetermined Significance	5.7%
181	Thyroid Nodule	5.7%
182	Adrenoleukodystrophy	5.6%
183	Lymphoproliferative Disorders	5.6%
184	Testicular Diseases	5.6%
185	Paraproteinemias	5.5%
186	Lymphopenia	5.5%
187	Ovarian Diseases	5.5%
188	Empty Sella Syndrome	5.5%
189	Hyperpituitarism	5.5%
190	Hypopituitarism	5.5%
191	Hypophysitis	5.5%
192	Homocystinuria	5.5%
193	Hyperlipoproteinemia Type III	5.4%
194	Glycogen storage disease type II	5.3%
195	Testicular Neoplasms	5.3%
196	Serum Sickness	5.2%
197	Gaucher Disease	5.2%
198	Mitochondrial Myopathies	5.1%
199	anaphylaxis	5.1%
200	Cushing Syndrome	5.1%
201	Food Allergy	5.1%
202	Hyperaldosteronism	5.1%
203	Hyperparathyroidism, Secondary	5.1%
204	Hypoaldosteronism	5.1%
205	Thyrotoxicosis	5.1%
206	Hyperparathyroidism, Primary	5.1%
207	Thyroid Hormone Resistance Syndrome	5.1%
208	Anaphylactic shock	5.1%
209	Myelinolysis, Central Pontine	5.1%
210	Thrombocytopenic purpura	5.1%
211	Acidosis, Lactic	5.1%
212	Calciphylaxis	5.1%
213	Hemosiderosis	5.1%
214	Ketosis	5.1%
215	Ketonuria	5.1%
216	Ketoacidosis	5.1%
217	Ketonemia	5.1%
218	Vascular calcification	5.1%
219	Asthma, Aspirin-Induced	5.1%
220	Reye Syndrome	5.1%
221	Hepatic Encephalopathy	5%
222	Prolactinoma	5%
223	Growth Hormone-Secreting Pituitary Adenoma	5%
224	Giant Cell Arteritis	5%
225	Hypoalphalipoproteinemias	5%
226	Temporal Arteritis	5%
227	Amyloid Neuropathies, Familial	5%
228	Renal tubular acidosis	4.9%
229	Pituitary Adenoma	4.8%
230	Pituitary Neoplasms	4.8%
231	Nelson Syndrome	4.7%
232	Hypergammaglobulinemia	4.6%
233	Zellweger Syndrome	4.6%
234	Agammaglobulinemia	4.6%
235	Kounis Syndrome	4.6%
236	Diabetes Insipidus	4.5%
237	HIV Infections	4.5%
238	Transfusion-Related Acute Lung Injury	4.5%
239	Menkes Kinky Hair Syndrome	4.5%
240	Myelitis, Transverse	4.5%
241	MELAS Syndrome	4.5%
242	Multiple Myeloma	4.5%
243	Porphyrias, Hepatic	4.4%
244	Neuronal Ceroid-Lipofuscinoses	4.4%
245	Child Nutrition Disorders	4.3%
246	Hypervitaminosis A	4.3%
247	Infant Nutrition Disorders	4.3%
248	Malnutrition	4.3%
249	Necrobiosis Lipoidica Diabeticorum	4.3%
250	Tay-Sachs Disease	4.3%
251	Fanconi Anemia	4.3%
252	Hepatolenticular Degeneration	4.3%
253	Niemann-Pick Disease, Type C	4.3%
254	Respiratory Hypersensitivity	4.3%
255	Milk Allergy	4.2%
256	Schnitzler Syndrome	4.2%
257	Hashimoto Disease	4.2%
258	Wheat Hypersensitivity	4.2%
259	Wernicke Encephalopathy	4.2%
260	Refsum Disease	4.2%
261	Fabry Disease	4.2%
262	Sezary Syndrome	4.2%
263	Sick Building Syndrome	4.1%
264	Multiple Chemical Sensitivity	4.1%
265	Myxedema	4.1%
266	Orchitis	4.1%
267	Plasmacytoma	4.1%
268	Tumor Lysis Syndrome	4.1%
269	Urticaria	4.1%
270	Vasculitis, Leukocytoclastic, Cutaneous	4.1%
271	Kallmann Syndrome	4.1%
272	Miller Fisher Syndrome	4.1%
273	Acidosis, Respiratory	4.1%
274	Adiposis Dolorosa	4.1%
275	Alkalosis, Respiratory	4.1%
276	HTLV-I Infections	4.1%
277	Job Syndrome	4.1%
278	Ovarian Hyperstimulation Syndrome	4%
279	Hyperprolactinemia	4%
280	Alkaptonuria	4%
281	Glycogen Storage Disease	4%
282	Hypophosphatasia	4%
283	Osteoporosis, Postmenopausal	4%
284	Propionic acidemia	4%
285	Dihydropyrimidine Dehydrogenase Deficiency	4%
286	Cystinosis	4%
287	granulosa cell tumor	4%
288	Carcinoma, Ovarian Epithelial	4%
289	Hermaphroditism	3.9%
290	Disorders of Sex Development	3.9%
291	Pituitary Apoplexy	3.8%
292	Hypercholesterolemia	3.8%
293	Hyperlipoproteinemias	3.8%
294	Hypertriglyceridemia	3.8%
295	Friedreich Ataxia	3.7%
296	Mucopolysaccharidosis III	3.7%
297	Klinefelter Syndrome	3.6%
298	Multiple Endocrine Neoplasia	3.5%
299	Pancreatic Neoplasm	3.5%
300	Lymphoma	3.4%
301	Mastocytosis	3.4%
302	Corpus Luteum Cyst	3.4%
303	Ovarian Cysts	3.4%
304	Drug Eruptions	3.4%
305	Gigantism	3.4%
306	Kearns-Sayre syndrome	3.4%
307	Chronic granulomatous disease	3.4%
308	Heavy Chain Disease	3.4%
309	Cockayne Syndrome	3.4%
310	Acromegaly	3.4%
311	Nephrocalcinosis	3.4%
312	Tetany	3.4%
313	Dermatitis, Allergic Contact	3.4%
314	Mastocytosis, Systemic	3.3%
315	Anovulation	3.3%
316	HIV Seropositivity	3.3%
317	Oophoritis	3.3%
318	Cerebral Amyloid Angiopathy	3.3%
319	Leydig Cell Tumor	3.1%
320	Glycogen Storage Disease Type I	3%
321	Glycogen Storage Disease Type V	3%
322	Optic Atrophy, Hereditary, Leber	3%
323	Hyperandrogenism	3%
324	Cryptorchidism	2.9%
325	Familial Periodic Paralysis	2.9%
326	Acquired Immunodeficiency Syndrome	2.9%
327	AIDS related complex	2.9%
328	Infectious Mononucleosis	2.9%
329	Sjogren-Larsson Syndrome	2.9%
330	Cryoglobulinemia	2.9%
331	Gonadal Dysgenesis	2.9%
332	POEMS Syndrome	2.9%
333	Adrenogenital Syndrome	2.9%
334	Ovotesticular Disorders of Sex Development	2.9%
335	Variegate Porphyria	2.9%
336	Acute intermittent porphyria	2.9%
337	Porphyria Cutanea Tarda	2.9%
338	Renal Aminoacidurias	2.8%
339	Fanconi Syndrome	2.8%
340	Pseudohypoaldosteronism	2.8%
341	Liddle Syndrome	2.8%
342	Angioedema	2.8%
343	Hodgkin Disease	2.8%
344	Leukemia, Plasma Cell	2.8%
345	Lymphoma, Non-Hodgkin	2.8%
346	Polycystic Ovary Syndrome	2.8%
347	Leukemia, T-Cell	2.8%
348	Acute Generalized Exanthematous Pustulosis	2.8%
349	Leukemia, B-Cell	2.8%
350	Xeroderma Pigmentosum	2.8%
351	Canavan Disease	2.7%
352	Alexander Disease	2.7%
353	Hydrops Fetalis	2.7%
354	Mucopolysaccharidosis II	2.7%
355	Deficiency Diseases	2.6%
356	Starvation	2.6%
357	Refeeding Syndrome	2.6%
358	AIDS-Related Opportunistic Infections	2.6%
359	Dermatitis, Atopic	2.5%
360	Gout	2.5%
361	Amyotrophic Lateral Sclerosis	2.5%
362	Asthma, Exercise-Induced	2.5%
363	Status Asthmaticus	2.5%
364	Multiple Endocrine Neoplasia Type 1	2.5%
365	AIDS Dementia Complex	2.5%
366	AIDS-Associated Nephropathy	2.5%
367	Lymphoma, Follicular	2.5%
368	T-Cell Lymphoma	2.5%
369	Mantle cell lymphoma	2.5%
370	Antley-Bixler Syndrome Phenotype	2.5%
371	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
372	Leukemia, Large Granular Lymphocytic	2.5%
373	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
374	Asthma	2.5%
375	Composite Lymphoma	2.4%
376	Erythema Nodosum	2.4%
377	Dermatitis, Photoallergic	2.4%
378	Lymphangioleiomyomatosis	2.4%
379	Hereditary Angioedema Type III	2.3%
380	Hereditary Angioedema Types I and II	2.3%
381	Lymphoma, T-Cell, Cutaneous	2.3%
382	Lymphoma, AIDS-Related	2.3%
383	Enteropathy-Associated T-Cell Lymphoma	2.3%
384	Primary Effusion Lymphoma	2.3%
385	Mycosis Fungoides	2.3%
386	Lymphomatoid Papulosis	2.3%
387	Plasmablastic lymphoma	2.3%
388	Waldenstrom Macroglobulinemia	2.2%
389	Wiskott-Aldrich Syndrome	2.2%
390	Asthma, Occupational	2.2%
391	CREST Syndrome	2.2%
392	Farmer's Lung	2.2%
393	Angioedemas, Hereditary	2.2%
394	Hay fever	2.1%
395	Rhinitis, Allergic, Perennial	2.1%
396	Hypokalemic periodic paralysis	2.1%
397	Frontotemporal dementia	2.1%
398	Cystinuria	2.1%
399	Aspergillosis, Allergic Bronchopulmonary	2.1%
400	Turner Syndrome	2%
401	Lymphomatoid Granulomatosis	2%
402	Albinism	2%
403	Carcinoma, Pancreatic Ductal	2%
404	Arthritis, Gouty	1.9%
405	Toxic Epidermal Necrolysis	1.8%
406	Stevens-Johnson Syndrome	1.8%
407	insulinoma	1.8%
408	Gastrinoma	1.8%
409	Glucagonoma	1.8%
410	Carcinoma, Endometrioid	1.8%
411	Burkitt Lymphoma	1.7%
412	Kwashiorkor	1.7%
413	Magnesium Deficiency	1.7%
414	Potassium Deficiency	1.7%
415	Protein Deficiency	1.7%
416	Avitaminosis	1.7%
417	Ichthyosis, X-Linked	1.7%
418	Waterhouse-Friderichsen Syndrome	1.6%
419	Vipoma	1.6%
420	Obesity	1.4%
421	Ascorbic Acid Deficiency	1.3%
422	Vitamin A Deficiency	1.3%
423	Vitamin D Deficiency	1.3%
424	Vitamin E Deficiency	1.3%
425	Marasmus	1.3%
426	Obesity, Abdominal	1.1%
427	Denys-Drash Syndrome	1.1%
428	Folic Acid Deficiency	1.1%
429	Pellagra	1.1%
430	Thiamine Deficiency	1.1%
431	Vitamin B 12 Deficiency	1.1%
432	Vitamin B 6 Deficiency	1.1%
433	Pyridoxine Deficiency	1.1%
434	Beriberi	0.9%
435	Pediatric Obesity	0.9%
436	Vitamin K Deficiency	0.8%
437	Prader-Willi Syndrome	0.8%
438	Anemia, Pernicious	0.7%
439	Scurvy	0.7%
440	Subacute Combined Degeneration	0.5%

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