MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Amyloidosis

(UMLS:C0002726)

Definition:: A group of sporadic, familial and/or inherited, degenerative, and infectious disease processes, linked by the common theme of abnormal protein folding and deposition of AMYLOID. As the amyloid deposits enlarge they displace normal tissue structures, causing disruption of function. Various signs and symptoms depend on the location and size of the deposits.
UMLS ID:: C0002726
MeSH ID:: D000686

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.845.500

Synonym(s)

Amyloidosis

AMYLOID

AMYLOIDOSIS

Amyloid disease

Amyloidosis, NOS

Amyloidosis, unspecified

amyloid disease

amyloid diseases

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Lenalidomide	FAERS: 106 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
2	Thalidomide	FAERS: 26		OFFSIDES SIDER US FAERS
3	Bortezomib	FAERS: 22 Canada Vigilance: 4		Canada Vigilance SIDER US FAERS
4	pomalidomide	FAERS: 12 Canada Vigilance: 2		Canada Vigilance US FAERS
5	Droxidopa	FAERS: 7		US FAERS
6	apixaban	FAERS: 7		US FAERS
7	Tacrolimus	FAERS: 6		US FAERS
8	Clopidogrel	FAERS: 4		US FAERS
9	Enfuvirtide	FAERS: 4		US FAERS
10	LCZ 696	FAERS: 4		US FAERS
11	Omeprazole	FAERS: 4		US FAERS
12	Phentermine	FAERS: 4		US FAERS
13	Teriparatide	FAERS: 4		US FAERS
14	carfilzomib	FAERS: 4		US FAERS
15	PCI 32765	FAERS: 3		US FAERS
16	Rosiglitazone	FAERS: 3	15983227	CTD US FAERS
17	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 2		OFFSIDES US FAERS
18	Azacitidine	FAERS: 2		US FAERS
19	Bosentan	FAERS: 2		US FAERS
20	Celecoxib	FAERS: 2		US FAERS
21	Cyclosporine	FAERS: 2		US FAERS
22	Dabigatran	FAERS: 2		US FAERS
23	Diclofenac	FAERS: 2		US FAERS
24	Digoxin	FAERS: 2		US FAERS
25	Gemfibrozil	FAERS: 2		US FAERS
26	Leflunomide	FAERS: 2		US FAERS
27	Levofloxacin	FAERS: 2		US FAERS
28	Liraglutide	FAERS: 2		US FAERS
29	Phentermine	FAERS: 2		US FAERS
30	Rivaroxaban	FAERS: 2		US FAERS
31	Rosuvastatin Calcium	FAERS: 2		OFFSIDES US FAERS
32	Sevelamer	FAERS: 2		US FAERS
33	Sildenafil Citrate	FAERS: 2		US FAERS
34	Warfarin	FAERS: 2		US FAERS
35	Aspirin	FAERS: 1		OFFSIDES US FAERS
36	Atorvastatin	FAERS: 1		US FAERS
37	Axitinib	FAERS: 1		US FAERS
38	Canagliflozin	FAERS: 1		US FAERS
39	Carvedilol	FAERS: 1		US FAERS
40	Cisapride	FAERS: 1		US FAERS
41	Citalopram	FAERS: 1		US FAERS
42	Deferasirox	FAERS: 1		US FAERS
43	Dimethyl Fumarate	FAERS: 1		US FAERS
44	Fenofibrate	FAERS: 1		US FAERS
45	Fluticasone	FAERS: 1		US FAERS
46	Glatiramer Acetate	FAERS: 1		US FAERS
47	Imatinib Mesylate	FAERS: 1		US FAERS
48	Insulin Glargine	FAERS: 1		US FAERS
49	Lansoprazole	FAERS: 1		US FAERS
50	MDV 3100	FAERS: 1		US FAERS
51	Melphalan	FAERS: 1	10578165 17130952 18641023	CTD US FAERS
52	Methotrexate	FAERS: 1		US FAERS
53	Methotrexate	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
54	Sirolimus	FAERS: 1		US FAERS
55	Sotalol	FAERS: 1		US FAERS
56	Tadalafil	FAERS: 1		OFFSIDES US FAERS
57	Thyroxine	FAERS: 1		US FAERS
58	Triumeq	FAERS: 1		US FAERS
59	Valsartan	FAERS: 1		US FAERS
60	Vemurafenib	FAERS: 1		US FAERS
61	Vitamin K	FAERS: 1		US FAERS
62	Voriconazole	FAERS: 1		US FAERS
63	Zoledronic Acid	FAERS: 1		OFFSIDES US FAERS
64	cefuroxime axetil	FAERS: 1		US FAERS
65	pazopanib	FAERS: 1		US FAERS
66	teduglutide	FAERS: 1		US FAERS
67	tofacitinib	FAERS: 1		US FAERS
68	Acarbose			OFFSIDES
69	Aminophylline		7986221	CTD
70	Atorvastatin			OFFSIDES
71	Beclomethasone			OFFSIDES
72	Bleomycin			OFFSIDES
73	Bleomycin			OFFSIDES
74	Calcitriol			OFFSIDES
75	Carisoprodol			OFFSIDES
76	Chlorhexidine			OFFSIDES
77	Chlorthalidone			OFFSIDES
78	Cladribine			SIDER
79	Clozapine			OFFSIDES
80	Colchicine		1499522 1604496 17505274	CTD
81	Dapsone			OFFSIDES
82	Diazepam			OFFSIDES
83	Diethylstilbestrol		15469931	CTD
84	Doripenem			OFFSIDES
85	Doxazosin			OFFSIDES
86	Doxorubicin			OFFSIDES
87	Everolimus		24040781	CTD
88	Fluvastatin			OFFSIDES
89	Fondaparinux			OFFSIDES
90	Fosinopril			OFFSIDES
91	Glucovance			OFFSIDES
92	Haloperidol			OFFSIDES
93	Imatinib Mesylate			OFFSIDES
94	Isoniazid			OFFSIDES
95	Lovastatin			OFFSIDES
96	Metformin		15983227	CTD
97	Metolazone			OFFSIDES
98	Milrinone		12148128	CTD OFFSIDES
99	Misoprostol			OFFSIDES
100	Mycophenolic Acid			OFFSIDES
101	Nifedipine			OFFSIDES
102	Nitroglycerin			OFFSIDES
103	Oxazepam		7982536	CTD
104	Pamidronate			OFFSIDES
105	Pemetrexed			OFFSIDES
106	Pentazocine			OFFSIDES
107	Pergolide			OFFSIDES
108	Phenytoin		2511368	CTD
109	Pyridoxal Phosphate			OFFSIDES
110	Ribavirin			OFFSIDES
111	Rosuvastatin Calcium			OFFSIDES
112	Salmeterol Xinafoate			OFFSIDES
113	Sevelamer			OFFSIDES
114	Sevelamer			OFFSIDES
115	Sodium Bicarbonate			OFFSIDES
116	Sodium picosulfate			OFFSIDES
117	Sulfasalazine			OFFSIDES
118	Terbutaline		7986221	CTD
119	Trientine		23541064	CTD
120	Trimethoprim, Sulfamethoxazole Drug Combination			OFFSIDES
121	VAD protocol		18344643	CTD
122	Vincristine			OFFSIDES
123	alfacalcidol			OFFSIDES
124	alpha-Tocopherol			OFFSIDES
125	benidipine			OFFSIDES
126	chlorhexidine gluconate			OFFSIDES
127	fexofenadine			OFFSIDES
128	fludarabine			OFFSIDES
129	fosfluconazole			OFFSIDES
130	geranylgeranylacetone			OFFSIDES
131	isosorbide-5-mononitrate			OFFSIDES
132	mecobalamin			OFFSIDES
133	pantethine			OFFSIDES
134	plaunotol			OFFSIDES
135	sennoside A&B			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Acid-Base Imbalance	31%
2	Calcium Metabolism Disorders	31%
3	Iron Metabolism Disorders	31%
4	Phosphorus Metabolism Disorders	31%
5	Water-Electrolyte Imbalance	31%
6	Lipid Metabolism Disorders	31%
7	Mitochondrial Diseases	31%
8	Glucose Metabolism Disorders	31%
9	Wasting Syndrome	27.9%
10	Hypercalcemia	26.7%
11	Hypocalcemia	26.7%
12	Milk-Alkali Syndrome	26.7%
13	Osteopenia	20.9%
14	Brain Diseases, Metabolic	20.5%
15	Acidosis	20%
16	Alkalosis	20%
17	Calcinosis	20%
18	Hyperglycemia	20%
19	Hyperinsulinism	20%
20	Hyperkalemia	20%
21	Hypernatremia	20%
22	Hypoglycemia	20%
23	Hypokalemia	20%
24	Hyponatremia	20%
25	Lipodystrophy	20%
26	Xanthomatosis	20%
27	Hypophosphatemia	20%
28	Metabolic acidosis	20%
29	Dyslipidemias	20%
30	Iron Overload	20%
31	Xanthoma	20%
32	Nutrition Disorders	18.5%
33	Pseudohypoparathyroidism	18.1%
34	Rickets	17.3%
35	Brain Diseases, Metabolic, Inborn	15.9%
36	Leigh Disease	15.2%
37	Hyperhomocysteinemia	15.1%
38	Acidosis, Lactic	14.8%
39	Calciphylaxis	14.8%
40	Hemosiderosis	14.8%
41	Ketosis	14.8%
42	Ketonuria	14.8%
43	Ketoacidosis	14.8%
44	Ketonemia	14.8%
45	Vascular calcification	14.8%
46	Hypolipoproteinemias	14.6%
47	Hyperlipoproteinemia Type IV	14.5%
48	Hyperlipoproteinemia Type V	14.5%
49	Diabetes Mellitus	14.3%
50	Carbamoyl-Phosphate Synthase I Deficiency Disease	13.8%
51	Lactose Intolerance	13.7%
52	Dehydration	13.6%
53	Lipomatosis	13.6%
54	Water Intoxication	13.6%
55	Werner Syndrome	13.6%
56	Diabetic Ketoacidosis	13.5%
57	Hyperlipidemia, Familial Combined	13.4%
58	Achlorhydria	13.3%
59	Amino Acid Metabolism, Inborn Errors	13.3%
60	Bloom Syndrome	13.3%
61	Carbohydrate Metabolism, Inborn Errors	13.3%
62	Metal Metabolism, Inborn Errors	13.3%
63	Osteoporosis	13.3%
64	Progeria	13.3%
65	Lysosomal Storage Diseases	13.3%
66	Bone Demineralization, Pathologic	13.3%
67	Cytochrome-c Oxidase Deficiency	13.3%
68	Peroxisomal Disorders	13.3%
69	Post-Traumatic Osteoporosis	13.3%
70	Celiac Disease	13.2%
71	Sprue, Tropical	13.2%
72	Steatorrhea	13.2%
73	Sprue	13.2%
74	Osteomalacia	13%
75	Hyperlipoproteinemia Type III	12.7%
76	Smith-Lemli-Opitz Syndrome	12.6%
77	Galactosemias	12.5%
78	Urea Cycle Disorders, Inborn	12.5%
79	Tyrosinemias	12.5%
80	Hypercholesterolemia	12.2%
81	Hyperlipoproteinemias	12.2%
82	Hypertriglyceridemia	12.2%
83	Congenital Hyperinsulinism	12.2%
84	Hypoalphalipoproteinemias	12%
85	Amyotrophic Lateral Sclerosis	11.6%
86	Familial Hypophosphatemic Rickets	11.5%
87	Mitochondrial Encephalomyopathies	11.5%
88	Frontotemporal dementia	11.3%
89	Gaucher Disease	10.9%
90	Hyperphosphaturia	10.9%
91	Glycogen storage disease type II	10.6%
92	Homocystinuria	10.4%
93	Child Nutrition Disorders	10.3%
94	Hypervitaminosis A	10.3%
95	Infant Nutrition Disorders	10.3%
96	Malnutrition	10.3%
97	Mitochondrial Myopathies	10.2%
98	Myelinolysis, Central Pontine	10.1%
99	Glycosuria	9.9%
100	Reye Syndrome	9.9%
101	Acidosis, Respiratory	9.9%
102	Adiposis Dolorosa	9.9%
103	Alkalosis, Respiratory	9.9%
104	Hepatic Encephalopathy	9.8%
105	Tay-Sachs Disease	9.8%
106	Nesidioblastosis	9.8%
107	Alkaptonuria	9.8%
108	Glycogen Storage Disease	9.8%
109	Hypophosphatasia	9.8%
110	Insulin Resistance	9.8%
111	Osteoporosis, Postmenopausal	9.8%
112	Propionic acidemia	9.8%
113	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
114	Cystinosis	9.8%
115	Renal tubular acidosis	9.7%
116	Niemann-Pick Disease, Type C	9.3%
117	Neuronal Ceroid-Lipofuscinoses	9%
118	HIV Wasting Syndrome	8.8%
119	Fabry Disease	8.5%
120	HIV-Associated Lipodystrophy Syndrome	8.4%
121	MELAS Syndrome	8.2%
122	Renal Osteodystrophy	8.2%
123	Renal rickets	8.2%
124	Porphyrias, Hepatic	8.1%
125	Glycogen Storage Disease Type I	8.1%
126	Glycogen Storage Disease Type V	8.1%
127	Zellweger Syndrome	8%
128	Mucopolysaccharidosis III	8%
129	Adrenoleukodystrophy	8%
130	Necrobiosis Lipoidica Diabeticorum	7.9%
131	Menkes Kinky Hair Syndrome	7.9%
132	Fanconi Anemia	7.8%
133	Wernicke Encephalopathy	7.7%
134	Gestational Diabetes	7.7%
135	Latent Autoimmune Diabetes in Adults	7.7%
136	Diabetes Mellitus, Experimental	7.6%
137	Hepatolenticular Degeneration	7.4%
138	Nephrocalcinosis	7.4%
139	Tetany	7.4%
140	Refsum Disease	7.3%
141	Glycosuria, Renal	7.3%
142	Deficiency Diseases	6.7%
143	Starvation	6.7%
144	Refeeding Syndrome	6.7%
145	Friedreich Ataxia	6.5%
146	Familial Periodic Paralysis	6%
147	Variegate Porphyria	5.9%
148	Acute intermittent porphyria	5.9%
149	Porphyria Cutanea Tarda	5.9%
150	Renal Aminoacidurias	5.8%
151	Fanconi Syndrome	5.8%
152	Pseudohypoaldosteronism	5.8%
153	Liddle Syndrome	5.8%
154	Kernicterus	5.7%
155	Kearns-Sayre syndrome	5.7%
156	Cockayne Syndrome	5.7%
157	Canavan Disease	5.4%
158	Alexander Disease	5.4%
159	Sjogren-Larsson Syndrome	5.4%
160	Mucopolysaccharidosis II	5.3%
161	Ataxia Telangiectasia	5.1%
162	Gout	5%
163	Kwashiorkor	4.9%
164	Magnesium Deficiency	4.9%
165	Potassium Deficiency	4.9%
166	Protein Deficiency	4.9%
167	Avitaminosis	4.9%
168	Optic Atrophy, Hereditary, Leber	4.9%
169	Antley-Bixler Syndrome Phenotype	4.9%
170	Hypokalemic periodic paralysis	4.9%
171	Cystinuria	4.8%
172	Xeroderma Pigmentosum	4.5%
173	CREST Syndrome	4.2%
174	Ascorbic Acid Deficiency	4.1%
175	Vitamin A Deficiency	4.1%
176	Vitamin D Deficiency	4.1%
177	Vitamin E Deficiency	4.1%
178	Marasmus	4.1%
179	Arthritis, Gouty	4.1%
180	Albinism	3.7%
181	Amyloid Neuropathies, Familial	3.7%
182	Folic Acid Deficiency	3.6%
183	Pellagra	3.6%
184	Thiamine Deficiency	3.6%
185	Vitamin B 12 Deficiency	3.6%
186	Vitamin B 6 Deficiency	3.6%
187	Pyridoxine Deficiency	3.6%
188	Beriberi	3.4%
189	Ichthyosis, X-Linked	3%
190	Obesity	2.6%
191	Obesity, Abdominal	2.4%
192	Anemia, Pernicious	2.3%
193	Vitamin K Deficiency	2.1%
194	Pediatric Obesity	1.9%
195	Scurvy	1.8%
196	Prader-Willi Syndrome	1.6%
197	Subacute Combined Degeneration	1.2%

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