MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Adenomatous Polyposis Coli

(UMLS:C0032580)

Definition:: A polyposis syndrome due to an autosomal dominant mutation of the APC genes (GENES, APC) on CHROMOSOME 5. The syndrome is characterized by the development of hundreds of ADENOMATOUS POLYPS in the COLON and RECTUM of affected individuals by early adulthood.
UMLS ID:: C0032580
MeSH ID:: D011125

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.035.215.100|C04.588.274.476.411.307.089|C04.700.100

Classification 2:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.301.371.411.307.090|C06.405.249.411.307.090|C06.405.469.158.356.090|C06.405.469.491.307.090|C06.405.469.578.249

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.700.100

Synonym(s)

Adenomatous Polyposis Coli

APC - Adenomatous Polyposis Coli

APC - Adenomatous polyposis coli

APC - adenomatous polyposis coli

Adenomatous polyposis

Adenomatous polyposis coli

COLON NOS POLYPOSIS

FAMILIAL ADENOMATOUS POLYPOSIS 1

FAMILIAL POLYPOSIS

10.

FAP

11.

FAP - Familial adenomatous polyposis

12.

FPC - Familial polyposis coli

13.

Familial Adenomatous Polyposis

14.

Familial Adenomatous Polyposis Coli

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Octreotide	FAERS: 4		US FAERS
2	Dasatinib	FAERS: 2		US FAERS
3	Venlafaxine Hydrochloride	FAERS: 2		US FAERS
4	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
5	Fentanyl	FAERS: 1		US FAERS
6	Pregabalin	FAERS: 1		US FAERS
7	Risedronic Acid	FAERS: 1		US FAERS
8	Temozolomide	FAERS: 1		US FAERS
9	ambrisentan	FAERS: 1		US FAERS
10	rofecoxib	FAERS: 1		OFFSIDES US FAERS
11	2-keto-4-methylthiobutyric acid		28414304	CTD
12	Celecoxib		View details 16215675 16681880 19003578 19706164	CTD
13	Ciclopirox			OFFSIDES
14	Ciclopirox			OFFSIDES
15	Desonide			OFFSIDES
16	Dicyclomine			OFFSIDES
17	Dinoprostone		17942926	CTD
18	Diphenhydramine			OFFSIDES
19	Eicosapentaenoic Acid		22830632	CTD
20	Erythromycin			OFFSIDES
21	Flurbiprofen		10680582	CTD
22	Fosinopril			OFFSIDES
23	Leukotriene B4		17942926	CTD
24	Mupirocin			OFFSIDES
25	Naloxone			OFFSIDES
26	Octreotide	Canada Vigilance: 1		Canada Vigilance
27	Polylysine			OFFSIDES
28	Progesterone			OFFSIDES
29	Quercetin		22830632	CTD
30	Resveratrol		11588890 26223300	CTD
31	Risedronic Acid			OFFSIDES
32	Sulindac		View details 11535846 11874996 12394442 15623613 16460482 17611924 19003578	CTD
33	Tamoxifen			OFFSIDES
34	Tretinoin			OFFSIDES
35	Zoledronic Acid			OFFSIDES
36	benzonatate			OFFSIDES
37	chlordiazepoxide, clidinium drug combination			OFFSIDES
38	dibenzoylmethane		17942926	CTD
39	proanthocyanidin		18205911	CTD
40	roxatidine acetate			OFFSIDES
41	sulforafan		17942926	CTD
42	sulindac sulfone		16150858	CTD
43	turmeric extract		22830632	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Colonic Neoplasms	50.3%
2	Zollinger-Ellison syndrome	47.3%
3	Rectal Neoplasms	44.8%
4	Cecal Neoplasms	44%
5	Duodenal Neoplasms	44%
6	Sigmoid Neoplasms	43.6%
7	Anus Neoplasms	38.1%
8	Esophageal Neoplasms	34.1%
9	Proctocolitis	33%
10	Stomach Neoplasms	32.9%
11	Appendiceal Neoplasms	30.2%
12	Dysentery	29.6%
13	Enteritis	29.6%
14	Enterocolitis	29.6%
15	Inflammatory Bowel Diseases	29.6%
16	Peutz-Jeghers Syndrome	29.5%
17	Colorectal Neoplasms	28.1%
18	Duodenitis	27.7%
19	Ileitis	27.7%
20	Erosive Duodenitis	27.7%
21	Colitis	25.6%
22	Intestinal Atresia	25.4%
23	Mesenteric vascular insufficiency	24.4%
24	Mesenteric Vascular Occlusion	24.3%
25	Intestinal Fistula	24.2%
26	Enterocutaneous Fistula	24.2%
27	Duodenal Obstruction	24.1%
28	Peritoneal Neoplasms	24%
29	Rectal Fistula	23.6%
30	Anal Fistula	23.6%
31	Intestinal Neoplasms	23%
32	Gastrointestinal Stromal Tumors	22.4%
33	Pancreatic Neoplasm	22.4%
34	Duodenogastric Reflux	22.1%
35	Peptic Ulcer	22.1%
36	Proctitis	22.1%
37	Multiple Endocrine Neoplasia	22%
38	Liver neoplasms	21.8%
39	Cecal Diseases	21.4%
40	Ileal Diseases	21.4%
41	Intestinal Obstruction	21.4%
42	Intestinal Perforation	21.4%
43	Jejunal Diseases	21.4%
44	Pneumatosis Cystoides Intestinalis	21.4%
45	Rectal Diseases	21.4%
46	Appendicitis	20.3%
47	Gastrointestinal Neoplasms	20.2%
48	Esophagitis	20.1%
49	Gastritis	20.1%
50	Tuberous Sclerosis	20%
51	Intestinal Diseases, Parasitic	19.9%
52	Esophageal Diseases	19.6%
53	Gastroenteritis	19.6%
54	Stomach Diseases	19.6%
55	Pouchitis	19.2%
56	Adenomatous Polyposis Coli	18.9%
57	Hepatocellular Adenoma	18.7%
58	Crohn Disease	18.2%
59	Enterocolitis, Neutropenic	18.2%
60	Necrotizing Enterocolitis	18.2%
61	Gastrointestinal Hemorrhage	17.8%
62	Tuberculosis, Gastrointestinal	17.8%
63	Basal Cell Nevus Syndrome	17.3%
64	Colonic Pseudo-Obstruction	17.2%
65	Colonic Diseases, Functional	17.1%
66	Megacolon	17.1%
67	Enterocolitis, Pseudomembranous	16.7%
68	pseudomembranous colitis	16.7%
69	Dysentery, Bacillary	16.7%
70	Esophageal Atresia	16.7%
71	Nephroblastoma	16.1%
72	Carcinoma, Pancreatic Ductal	16%
73	Colonic Diseases	15.7%
74	Colitis, Ischemic	15.6%
75	Barrett Esophagus	15.1%
76	Multiple Endocrine Neoplasia Type 1	15%
77	Bile Duct Neoplasms	14.8%
78	gallbladder neoplasm	14.8%
79	Liver Neoplasms, Experimental	14.7%
80	Cronkhite-Canada Syndrome	14.6%
81	Intestinal Polyposis	14.6%
82	Duodenal Ulcer	14.5%
83	Peptic Ulcer Perforation	14.5%
84	Gastric ulcer	14.5%
85	Choledochal Cyst	14.4%
86	Digestive System Neoplasms	14.2%
87	Biliary Tract Diseases	14.2%
88	Liver diseases	14.2%
89	Pancreatic Diseases	14.2%
90	Esophageal and Gastric Varices	13.9%
91	Cystadenoma	13.4%
92	Mesothelioma	13.4%
93	Fecal Incontinence	13.3%
94	Fecal Impaction	13.3%
95	Intussusception	13.3%
96	Ileus	13.3%
97	Meconium ileus	13.3%
98	Neoplasms, Neuroepithelial	12.8%
99	Gliomatosis cerebri	12.8%
100	Pancreatic Fistula	12.6%
101	Lactose Intolerance	12.5%
102	insulinoma	12.4%
103	Hemorrhoids	12.2%
104	Adenoma, Acidophil	12.2%
105	Afferent Loop Syndrome	12.1%
106	Celiac Disease	12.1%
107	Short Bowel Syndrome	12.1%
108	Sprue, Tropical	12.1%
109	Steatorrhea	12.1%
110	Rectocele	12.1%
111	Sprue	12.1%
112	Rectal Prolapse	12%
113	Cystic Fibrosis	12%
114	Pancreatic Cyst	11.9%
115	Irritable Bowel Syndrome	11.8%
116	Neurogenic Bowel	11.8%
117	Giardiasis	11.2%
118	Medulloblastoma	11.2%
119	Esophageal Stenosis	11%
120	Gastric Dilatation	11%
121	Gastric outlet obstruction	11%
122	Carcinoma, Lobular	11%
123	Vipoma	10.9%
124	Esophageal Perforation	10.2%
125	Gastrinoma	10.2%
126	Glucagonoma	10.2%
127	Deglutition Disorders	10.1%
128	Achlorhydria	10.1%
129	Gastric Antral Vascular Ectasia	10.1%
130	Peptic Ulcer Hemorrhage	10%
131	Gastroparesis	10%
132	Carcinoma, Ehrlich Tumor	9.9%
133	Carcinoma, Lewis Lung	9.9%
134	Basal cell carcinoma	9.8%
135	Carcinoma, Papillary	9.8%
136	Squamous cell carcinoma	9.8%
137	Carcinoma, Basal Cell	9.8%
138	Meningioma	9.8%
139	Denys-Drash Syndrome	9.7%
140	Carcinoma 256, Walker	9.7%
141	Melanoma, Experimental	9.6%
142	Hamartoma	9.5%
143	Neoplasms, Hormone-Dependent	9.5%
144	Neoplasms, Multiple Primary	9.5%
145	Paraneoplastic Syndromes	9.5%
146	Precancerous Conditions	9.5%
147	Neoplasms, Second Primary	9.5%
148	Acanthoma	9.4%
149	Neuroectodermal Tumors	9.3%
150	Adenomatosis, Pulmonary	9.3%
151	Melena	9.3%
152	Anal Fissure	9.2%
153	Intestinal Pseudo-Obstruction	9.2%
154	Superior Mesenteric Artery Syndrome	9.2%
155	Anal Ulcer	9.2%
156	Hematemesis	9.2%
157	Prolactinoma	9%
158	Growth Hormone-Secreting Pituitary Adenoma	9%
159	Cryptosporidiosis	9%
160	Ganglioneuroma	8.9%
161	Glioma	8.9%
162	Malignant Glioma	8.9%
163	Trophoblastic Neoplasms	8.9%
164	Retinoblastoma	8.9%
165	Leukemia, Experimental	8.8%
166	Porphyrias, Hepatic	8.8%
167	Paraneoplastic Encephalomyelitis	8.8%
168	Mammary Neoplasms, Experimental	8.7%
169	Cyst	8.7%
170	Neoplastic Processes	8.7%
171	Pregnancy Complications, Neoplastic	8.7%
172	melanoma	8.7%
173	Neoplasms, Experimental	8.7%
174	Hepatolenticular Degeneration	8.6%
175	Biliary cirrhosis	8.5%
176	Cystadenocarcinoma	8.5%
177	Mucoepidermoid Carcinoma	8.5%
178	leukemia	8.4%
179	Neoplasms, Germ Cell and Embryonal	8.4%
180	Germ Cell Cancer	8.4%
181	Choriocarcinoma	8.4%
182	Pruritus Ani	8.4%
183	Carcinoma	8.4%
184	Epithelioma	8.4%
185	Abdominal Neoplasms	8.2%
186	Head and Neck Neoplasms	8.2%
187	Soft Tissue Neoplasms	8.2%
188	Thoracic Neoplasms	8.2%
189	Leukemia, Radiation-Induced	8.2%
190	Dermoid Cyst	8.2%
191	Anus, Imperforate	8%
192	Anorectal Malformations	8%
193	Neoplasms, Radiation-Induced	8%
194	Composite Lymphoma	7.9%
195	Carcinosarcoma	7.8%
196	Hemangiosarcoma	7.8%
197	lymphangiosarcoma	7.8%
198	Parathyroid Neoplasms	7.7%
199	Thyroid Neoplasm	7.7%
200	Thyroid carcinoma	7.7%
201	Carcinoid Tumor	7.7%
202	Zellweger Syndrome	7.7%
203	Cholecystolithiasis	7.7%
204	Histiocytic Disorders, Malignant	7.7%
205	Endocrine Gland Neoplasms	7.6%
206	Eye Neoplasms	7.6%
207	Nervous System Neoplasms	7.6%
208	Bone neoplasms	7.6%
209	Skin Neoplasms	7.6%
210	Hematologic Neoplasms	7.6%
211	Bile Duct Diseases	7.5%
212	Cholelithiasis	7.5%
213	Chylous Ascites	7.5%
214	Fatty Liver	7.5%
215	Hepatitis	7.5%
216	Portal Hypertension	7.5%
217	Liver Cirrhosis	7.5%
218	Pancreatic Insufficiency	7.5%
219	Pancreatitis	7.5%
220	Pneumoperitoneum	7.5%
221	Focal Nodular Hyperplasia	7.5%
222	Hepatic Insufficiency	7.5%
223	Steatohepatitis	7.5%
224	Splenic Neoplasms	7.5%
225	Sarcoma, Experimental	7.5%
226	Congenital Hyperinsulinism	7.3%
227	Aicardi's syndrome	7.2%
228	Ichthyosis, X-Linked	7.2%
229	Bowen's Disease	7.2%
230	Leukemia, Plasma Cell	7.2%
231	Thymoma	7%
232	Astrocytoma	7%
233	Ependymoma	7%
234	oligodendroglioma	7%
235	Ganglioglioma	7%
236	gliosarcoma	7%
237	Anaplastic astrocytoma	7%
238	Anaplastic Oligodendroglioma	7%
239	Fatty Liver, Alcoholic	7%
240	Hepatitis, Alcoholic	7%
241	Liver Cirrhosis, Alcoholic	7%
242	Lymphoma	7%
243	Acoustic Neuroma	7%
244	Pancreatic Pseudocyst	7%
245	Adenofibroma	7%
246	Fibroadenoma	7%
247	Liver Diseases, Parasitic	7%
248	Fragile X Syndrome	6.9%
249	Hepatic Veno-Occlusive Disease	6.9%
250	Peliosis Hepatis	6.9%
251	Hepatopulmonary Syndrome	6.9%
252	Optic Nerve Glioma	6.9%
253	Hemoperitoneum	6.8%
254	Hepatomegaly	6.8%
255	Mesenteric Panniculitis	6.8%
256	Panniculitis, Peritoneal	6.8%
257	Peritonitis	6.8%
258	Peritoneal Fibrosis	6.8%
259	Encapsulating Peritoneal Sclerosis	6.8%
260	Biliary Fistula	6.8%
261	Gastric Fistula	6.8%
262	Hepatic Vein Thrombosis	6.8%
263	Liver Abscess	6.8%
264	Budd-Chiari Syndrome	6.8%
265	Esophageal motility disorders	6.8%
266	Mallory-Weiss Syndrome	6.8%
267	Pyloric Stenosis	6.8%
268	Albinism	6.7%
269	Neurilemmoma	6.6%
270	Hutchinson's Melanotic Freckle	6.6%
271	Melanoma, Amelanotic	6.6%
272	Alstrom Syndrome	6.5%
273	Tracheal Neoplasms	6.5%
274	Malignant Carcinoid Syndrome	6.4%
275	Chemical and Drug Induced Liver Injury	6.3%
276	Xeroderma Pigmentosum	6.3%
277	Leukemia L1210	6.3%
278	Leukemia P388	6.3%
279	Chondrosarcoma	6.3%
280	Craniopharyngioma	6.3%
281	leiomyosarcoma	6.3%
282	liposarcoma	6.3%
283	synovial sarcoma	6.3%
284	Neuroectodermal Tumor, Melanotic	6.3%
285	Angiomyolipoma	6.3%
286	Clear Cell Sarcoma of Soft Tissue	6.3%
287	Alveolar Soft Part Sarcoma	6.3%
288	Neuroendocrine Tumors	6.3%
289	Sarcoma, Myeloid	6.3%
290	Hepatorenal Syndrome	6.3%
291	Mucopolysaccharidosis II	6.2%
292	Lymphomatoid Granulomatosis	6.2%
293	Choledocholithiasis	6.2%
294	Diverticulitis	6.2%
295	Dumping Syndrome	6.2%
296	Kartagener Syndrome	6.1%
297	Menkes Kinky Hair Syndrome	6.1%
298	Cockayne Syndrome	6.1%
299	Glioblastoma	6.1%
300	Neuroblastoma	6.1%
301	Glioblastoma Multiforme	6.1%
302	Liver Abscess, Amebic	6.1%
303	CHARGE Syndrome	6%
304	Anemia, Sickle Cell	6%
305	Thalassemia	6%
306	Muscular Dystrophy, Duchenne	6%
307	Endometrial Stromal Sarcoma	5.9%
308	Intestinal Diseases	5.9%
309	Carcinoma, Ovarian Epithelial	5.8%
310	Diverticulum	5.7%
311	Diverticulosis	5.7%
312	Ganglioneuroblastoma	5.6%
313	Adrenoleukodystrophy	5.6%
314	Sarcoma 180	5.6%
315	Nail-Patella Syndrome	5.6%
316	Testicular Neoplasms	5.6%
317	Fibrosarcoma	5.6%
318	Osteosarcoma	5.6%
319	Variegate Porphyria	5.5%
320	Acute intermittent porphyria	5.5%
321	Porphyria Cutanea Tarda	5.5%
322	Erythroplasia	5.5%
323	Follicular cyst	5.5%
324	Mucocele	5.5%
325	Pilonidal Cyst	5.5%
326	Thyroglossal Cyst	5.5%
327	Synovial Cyst	5.5%
328	Aberrant Crypt Foci	5.5%
329	Beckwith-Wiedemann Syndrome	5.4%
330	Wolf-Hirschhorn Syndrome	5.4%
331	Adenocarcinoma	5.4%
332	Carcinoma in Situ	5.4%
333	Carcinoma, Transitional Cell	5.4%
334	Papilloma	5.4%
335	Pseudomyxoma Peritonei	5.4%
336	Papillomatosis	5.4%
337	Carcinoma, Large Cell	5.4%
338	Carcinoma, Small Cell	5.4%
339	Neurofibrosarcoma	5.4%
340	Carcinoid Heart Disease	5.4%
341	Multiple Epiphyseal Dysplasia	5.4%
342	Osteochondrodysplasias	5.4%
343	Pelger-Huet Anomaly	5.4%
344	Werner Syndrome	5.4%
345	Myasthenic Syndromes, Congenital	5.4%
346	Lymphangioleiomyomatosis	5.3%
347	Holoprosencephaly	5.3%
348	Leukoplakia, Oral	5.3%
349	Paraneoplastic Cerebellar Degeneration	5.2%
350	Wiskott-Aldrich Syndrome	5.2%
351	Malignant Fibrous Histiocytoma	5.2%
352	Marfan Syndrome	5.2%
353	Thyroid Nodule	5.1%
354	Ameloblastoma	5.1%
355	Angiokeratoma	5.1%
356	Chordoma	5.1%
357	Hemangioma	5.1%
358	hemangiopericytoma	5.1%
359	Lymphangioma	5.1%
360	Mesenchymoma	5.1%
361	Nevus	5.1%
362	Teratoma	5.1%
363	Hepatoblastoma	5.1%
364	Mixed Tumor, Mullerian	5.1%
365	Germinoma	5.1%
366	Teratocarcinoma	5.1%
367	Angiofibroma	5.1%
368	Sarcoma	5.1%
369	Neoplastic Syndromes, Hereditary	5.1%
370	Mesoblastic Nephroma	5.1%
371	Smith-Magenis syndrome	5%
372	Leukoplakia	5%
373	Lymphocele	5%
374	Cri-du-Chat Syndrome	5%
375	Down Syndrome	5%
376	Trisomy 21	5%
377	Dwarfism	5%
378	Breast Cyst	5%
379	Actinic keratosis	5%
380	Mediastinal Cyst	5%
381	Neoplasm Invasiveness	5%
382	Neoplasm Metastasis	5%
383	Neoplasm Recurrence, Local	5%
384	Parovarian Cyst	5%
385	Pericardial Cyst	5%
386	Thymic Cyst	5%
387	Carcinogenesis	5%
388	Myxoid cyst	5%
389	Metastasis	5%
390	Retroperitoneal Neoplasms	4.9%
391	Fabry Disease	4.9%
392	Muscular Dystrophy	4.9%
393	Osteogenesis Imperfecta	4.9%
394	Myotonic Dystrophy	4.9%
395	Limbic Encephalitis	4.9%
396	Refsum Disease	4.8%
397	Rett Syndrome	4.8%
398	Paraganglioma	4.8%
399	Rhabdomyosarcoma	4.8%
400	Giant Cell Tumor of Bone	4.8%
401	Sjogren-Larsson Syndrome	4.8%
402	Smith-Lemli-Opitz Syndrome	4.7%
403	Nasopharyngeal carcinoma	4.7%
404	Rubinstein-Taybi Syndrome	4.7%
405	Esophageal Achalasia	4.7%
406	Ectodermal Dysplasia	4.7%
407	Aplasia Cutis Congenita	4.7%
408	Plasmacytoma	4.7%
409	Prader-Willi Syndrome	4.6%
410	Malignant histiocytosis	4.6%
411	Histiocytic sarcoma	4.6%
412	Adrenocortical carcinoma	4.6%
413	Lambert-Eaton Myasthenic Syndrome	4.6%
414	Autoimmune Lymphoproliferative Syndrome	4.6%
415	Corpus Luteum Cyst	4.6%
416	Ovarian Cysts	4.6%
417	Mouth Neoplasms	4.5%
418	Central Nervous System Neoplasms	4.5%
419	Vascular Neoplasms	4.5%
420	Thymus Neoplasms	4.5%
421	granulosa cell tumor	4.5%
422	Leydig Cell Tumor	4.5%
423	Neuronal Ceroid-Lipofuscinoses	4.5%
424	Genital Neoplasms, Female	4.5%
425	Angioedemas, Hereditary	4.5%
426	Breast Neoplasms, Male	4.5%
427	Triple Negative Breast Neoplasms	4.5%
428	Sickle Cell Trait	4.5%
429	Dermatofibrosarcoma	4.5%
430	Dermatofibrosarcoma Protuberans	4.5%
431	Kallmann Syndrome	4.4%
432	Opsoclonus-Myoclonus Syndrome	4.3%
433	Hydatidiform Mole	4.3%
434	Renal Cell Carcinoma	4.3%
435	Papillary Renal Cell Carcinoma	4.3%
436	Hodgkin Disease	4.3%
437	Lymphoma, Non-Hodgkin	4.3%
438	Amyloid Neuropathies, Familial	4.2%
439	Nose Neoplasms	4.2%
440	Glycogen storage disease type II	4.2%
441	Nesidioblastosis	4.2%
442	Cholangitis	4.2%
443	Cholecystitis	4.2%
444	Cholestasis	4.2%
445	Common Bile Duct Diseases	4.2%
446	Hepatitis, Chronic	4.2%
447	Liver Failure	4.2%
448	Pancreatitis, Chronic	4.2%
449	Non-alcoholic Fatty Liver Disease	4.2%
450	Chronic active hepatitis	4.2%
451	Adrenal Gland Neoplasms	4.2%
452	Genital Neoplasms, Male	4.2%
453	Uveal Neoplasms	4.2%
454	Urologic Neoplasms	4.2%
455	Sebaceous Gland Neoplasms	4.1%
456	Spinal Neoplasms	4.1%
457	Bone Marrow Neoplasms	4.1%
458	Pheochromocytoma	4.1%
459	Alveolar rhabdomyosarcoma	4.1%
460	Pituitary Adenoma	4%
461	Pituitary Neoplasms	4%
462	Myelitis, Transverse	4%
463	Carcinoma, Endometrioid	4%
464	Neoplasms, Glandular and Epithelial	4%
465	Polycystic Kidney Diseases	4%
466	Williams Syndrome	4%
467	Adenoid Cystic Carcinoma	4%
468	Adenocarcinoma, Clear Cell	4%
469	Cholangiocarcinoma	4%
470	Cervical Intraepithelial Neoplasia	4%
471	Primary amyloidosis	3.9%
472	Acute Chest Syndrome	3.9%
473	Hepatitis, Animal	3.9%
474	Hepatitis, Viral, Human	3.9%
475	Palatal Neoplasms	3.9%
476	Familial Mediterranean Fever	3.9%
477	Primary Ciliary Dyskinesia	3.9%
478	Galactosemias	3.9%
479	Urea Cycle Disorders, Inborn	3.9%
480	Tyrosinemias	3.9%
481	Liver Cirrhosis, Experimental	3.8%
482	Pancreatitis, Alcoholic	3.8%
483	Retinal Dysplasia	3.8%
484	Aniridia	3.8%
485	Epidermolysis Bullosa	3.7%
486	Canavan Disease	3.7%
487	Alexander Disease	3.7%
488	Ataxia Telangiectasia	3.7%
489	Optic Atrophy, Hereditary, Leber	3.6%
490	Hyperphosphaturia	3.6%
491	Gaucher Disease	3.6%
492	Central Nervous System Cysts	3.6%
493	ovarian neoplasm	3.6%
494	Fascioliasis	3.5%
495	Amino Acid Metabolism, Inborn Errors	3.5%
496	Carbohydrate Metabolism, Inborn Errors	3.5%
497	Metal Metabolism, Inborn Errors	3.5%
498	Progeria	3.5%
499	Lysosomal Storage Diseases	3.5%
500	Cytochrome-c Oxidase Deficiency	3.5%
501	Peroxisomal Disorders	3.5%
502	Echinococcosis, Hepatic	3.5%
503	Chemical and Drug Induced Liver Injury, Chronic	3.5%
504	Reye Syndrome	3.5%
505	Phyllodes Tumor	3.5%
506	Dysgerminoma	3.5%
507	Hemangioendothelioma	3.5%
508	Lipoma	3.5%
509	Myoma	3.5%
510	Myxoma	3.5%
511	Neuroma	3.5%
512	Seminoma	3.5%
513	Angiolipoma	3.5%
514	Myelolipoma	3.5%
515	Neoplasms, Bone Tissue	3.5%
516	Neoplasms, Fibrous Tissue	3.5%
517	Smooth Muscle Tumor	3.5%
518	Desmoplastic Small Round Cell Tumor	3.5%
519	Chondroma	3.5%
520	Enchondroma	3.5%
521	Mucopolysaccharidosis III	3.4%
522	Waldenstrom Macroglobulinemia	3.4%
523	Multiple Myeloma	3.4%
524	Hepatitis B, Chronic	3.4%
525	Hepatitis C, Chronic	3.4%
526	Homocystinuria	3.3%
527	Laryngopharyngeal Reflux	3.3%
528	Leigh Disease	3.3%
529	Deformity	3.3%
530	Pseudoxanthoma Elasticum	3.3%
531	Tay-Sachs Disease	3.3%
532	Cutis Laxa	3.3%
533	Retinitis Pigmentosa	3.3%
534	Pigmentary retinopathy	3.3%
535	Porokeratosis	3.3%
536	Keratoderma, Palmoplantar	3.3%
537	Chronic granulomatous disease	3.2%
538	Welander Distal Myopathy	3.2%
539	Klatskin Tumor	3.2%
540	Niemann-Pick Disease, Type C	3.2%
541	Lymphatic Metastasis	3.2%
542	Neoplasms, Unknown Primary	3.2%
543	Leukemic Infiltration	3.2%
544	Neoplasm Micrometastasis	3.2%
545	Classical Lissencephalies and Subcortical Band Heterotopias	3.2%
546	Leukemia, Myelomonocytic, Chronic	3.2%
547	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.2%
548	CREST Syndrome	3.1%
549	Hyperkeratosis, Epidermolytic	3.1%
550	Duane Retraction Syndrome	3%
551	Fetal Diseases	3%
552	Meningeal Neoplasms	3%
553	Carbamoyl-Phosphate Synthase I Deficiency Disease	3%
554	Myotonia Congenita	3%
555	Thrombasthenia	3%
556	Antithrombin III Deficiency	3%
557	Protein C Deficiency	3%
558	Brain Diseases, Metabolic, Inborn	3%
559	Afibrinogenemia	3%
560	Dystonia Musculorum Deformans	3%
561	Factor VII Deficiency	3%
562	Factor X Deficiency	3%
563	Factor XII Deficiency	3%
564	Hemophilia A	3%
565	Activated Protein C Resistance	3%
566	Factor II deficiency	3%
567	Factor VIII Deficiency	3%
568	Factor V deficiency	3%
569	Factor XI Deficiency	3%
570	Hypoprothrombinemias	3%
571	Fanconi Anemia	3%
572	Lafora Disease	3%
573	Unverricht-Lundborg Syndrome	3%
574	Anemia, Diamond-Blackfan	3%
575	Polycystic Kidney, Autosomal Dominant	3%
576	Mastocytosis	2.9%
577	Sturge-Weber Syndrome	2.9%
578	Hemangioma, Cavernous	2.9%
579	Polycystic Ovary Syndrome	2.9%
580	Leukemia, T-Cell	2.9%
581	Leukemia, B-Cell	2.9%
582	neurofibroma	2.9%
583	Lymphoma, Follicular	2.9%
584	T-Cell Lymphoma	2.9%
585	Mantle cell lymphoma	2.9%
586	Meconium Aspiration Syndrome	2.8%
587	Gastrointestinal Diseases	2.8%
588	Congenital Hypothyroidism	2.8%
589	Ear Neoplasms	2.8%
590	Eyelid Neoplasms	2.8%
591	Lung Neoplasms	2.8%
592	Pleural Neoplasms	2.8%
593	Dermatitis, Atopic	2.8%
594	Brain Neoplasms	2.8%
595	Salivary Gland Neoplasms	2.8%
596	Spinal Cord Neoplasms	2.8%
597	Tongue Neoplasms	2.8%
598	Charcot-Marie-Tooth Disease	2.8%
599	Antley-Bixler Syndrome Phenotype	2.8%
600	Uterine Neoplasms	2.8%
601	Vaginal Neoplasms	2.8%
602	Vulvar Neoplasms	2.8%
603	Uterine Cancer	2.8%
604	Fallopian Tube Neoplasms	2.8%
605	Adenoma	2.7%
606	fibroma	2.7%
607	Fibromatosis	2.7%
608	Osteoblastoma	2.7%
609	Osteoma	2.7%
610	Rhabdomyoma	2.7%
611	Chondromatosis	2.7%
612	Hemangioblastoma	2.7%
613	Lymphoma, Extranodal NK-T-Cell	2.7%
614	Alkaptonuria	2.6%
615	Glycogen Storage Disease	2.6%
616	Hypophosphatasia	2.6%
617	Propionic acidemia	2.6%
618	Dihydropyrimidine Dehydrogenase Deficiency	2.6%
619	Cystinosis	2.6%
620	Turner Syndrome	2.6%
621	Behcet Syndrome	2.6%
622	Pharyngeal Neoplasms	2.6%
623	Cholestasis, Extrahepatic	2.6%
624	Biliary Dyskinesia	2.6%
625	Cholangitis, Sclerosing	2.6%
626	Liver Failure, Acute	2.6%
627	Acalculous Cholecystitis	2.6%
628	End Stage Liver Disease	2.6%
629	Penile Neoplasms	2.6%
630	Prostatic Neoplasms	2.6%
631	Polycythemia Vera	2.5%
632	Xeroderma	2.5%
633	Mobius Syndrome	2.5%
634	Klinefelter Syndrome	2.5%
635	Huntington Disease	2.4%
636	Laryngeal neoplasm	2.4%
637	Mastocytoma	2.4%
638	Hypolipoproteinemias	2.4%
639	Papillon-Lefevre Disease	2.4%
640	Mastocytosis, Systemic	2.4%
641	Hyperlipidemia, Familial Combined	2.4%
642	Hyperlipoproteinemia Type III	2.4%
643	Leukemia, Myeloid, Chronic-Phase	2.4%
644	Bladder Neoplasm	2.4%
645	Kidney Neoplasm	2.4%
646	Ureteral Neoplasms	2.4%
647	Urethral Neoplasms	2.4%
648	Autoimmune hepatitis	2.4%
649	Hydrops Fetalis	2.3%
650	Familial Hypophosphatemic Rickets	2.3%
651	Meningeal Carcinomatosis	2.3%
652	Familial Periodic Paralysis	2.3%
653	Fibromatosis, Aggressive	2.3%
654	Fibromatosis, Abdominal	2.3%
655	Hyperhomocysteinemia	2.2%
656	Renal Aminoacidurias	2.2%
657	Fanconi Syndrome	2.2%
658	Pseudohypoaldosteronism	2.2%
659	Liddle Syndrome	2.2%
660	Hyperlipoproteinemia Type IV	2.2%
661	Hyperlipoproteinemia Type V	2.2%
662	Hepatitis, Viral, Animal	2.2%
663	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.2%
664	Leukemia, Large Granular Lymphocytic	2.2%
665	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.2%
666	Lymphoma, T-Cell, Cutaneous	2.2%
667	Lymphoma, AIDS-Related	2.2%
668	Enteropathy-Associated T-Cell Lymphoma	2.2%
669	Primary Effusion Lymphoma	2.2%
670	Glycogen Storage Disease Type I	2.2%
671	Glycogen Storage Disease Type V	2.2%
672	Hepatitis E	2.2%
673	Hepatitis B	2.2%
674	Hepatitis C	2.2%
675	Hepatitis A	2.2%
676	Hepatic Encephalopathy	2.2%
677	Bronchial Neoplasms	2.1%
678	Cell Transformation, Viral	2.1%
679	Gout	2.1%
680	Multiple Pulmonary Nodules	2.1%
681	Pseudohypoparathyroidism	2.1%
682	Supratentorial Neoplasms	2.1%
683	Friedreich Ataxia	2.1%
684	Endometrial Neoplasms	2.1%
685	Renal tubular acidosis	2.1%
686	Adenomatous Polyps	2%
687	Hypoalphalipoproteinemias	2%
688	Abdominal Cramps	2%
689	Abnormalities, Drug-Induced	2%
690	Amniotic Band Syndrome	2%
691	Asphyxia Neonatorum	2%
692	Infant, Premature, Diseases	2%
693	Situs Inversus	2%
694	Infantile Colic	2%
695	Hypopharyngeal Neoplasms	1.9%
696	Pleural Effusion, Malignant	1.9%
697	Hypopharyngeal Cancer	1.9%
698	Parotid Neoplasms	1.9%
699	Prostatic Neoplasms, Castration-Resistant	1.9%
700	Nelson Syndrome	1.9%
701	Dupuytren Contracture	1.9%
702	Burkitt Lymphoma	1.9%
703	Anencephaly	1.9%
704	Urticaria Pigmentosa	1.9%
705	Mycosis Fungoides	1.9%
706	Lymphomatoid Papulosis	1.9%
707	Plasmablastic lymphoma	1.9%
708	Hypokalemic periodic paralysis	1.9%
709	Cystinuria	1.9%
710	Eye Abnormalities	1.8%
711	Cardiovascular Abnormalities	1.8%
712	Glycosuria, Renal	1.8%
713	Skin Abnormalities	1.8%
714	Lymphatic Abnormalities	1.8%
715	Congenital Microtia	1.8%
716	Anemia, Neonatal	1.8%
717	Persistent Fetal Circulation Syndrome	1.8%
718	Congenital diaphragmatic hernia	1.8%
719	Umbilical hernia	1.8%
720	Massive Hepatic Necrosis	1.8%
721	Emphysematous Cholecystitis	1.8%
722	Sphincter of Oddi Dysfunction	1.8%
723	Maxillofacial Abnormalities	1.8%
724	Dural Arteriovenous Fistula	1.8%
725	Dextrocardia	1.8%
726	Brain Stem Neoplasms	1.7%
727	Arthritis, Gouty	1.7%
728	Acrocephalosyndactylia	1.7%
729	Nasopharyngeal Neoplasms	1.7%
730	Urogenital Abnormalities	1.7%
731	Neonatal Abstinence Syndrome	1.7%
732	Fetal Growth Retardation	1.6%
733	Fetal Hypoxia	1.6%
734	Congenital nystagmus	1.6%
735	Fetal Alcohol Spectrum Disorders	1.6%
736	Toxoplasmosis, Congenital	1.6%
737	Syphilis, Congenital	1.6%
738	Sezary Syndrome	1.6%
739	Tonsillar Neoplasms	1.6%
740	MELAS Syndrome	1.6%
741	Cerebellar Neoplasms	1.6%
742	Paranasal Sinus Neoplasms	1.6%
743	Choroid Plexus Papilloma	1.6%
744	Scimitar Syndrome	1.5%
745	Chorioamnionitis	1.5%
746	Abnormalities, Radiation-Induced	1.4%
747	Cleft Palate	1.4%
748	Craniosynostosis	1.4%
749	Syndactyly	1.4%
750	Brachycephaly	1.4%
751	Microcephaly	1.4%
752	Macrocephaly	1.4%
753	Maxillary Sinus Neoplasms	1.3%
754	Noonan Syndrome	1.3%
755	Ophthalmia Neonatorum	1.3%
756	Prune Belly Syndrome	1.3%
757	Twins, Conjoined	1.3%
758	Waardenburg Syndrome	1.3%
759	Radicular Cyst	1.3%
760	Porencephaly	1.2%
761	Rift Valley Fever	1.2%
762	Jaw Abnormalities	1.2%
763	Anophthalmos	1.2%
764	Hydranencephaly	1.2%
765	Microphthalmos	1.2%
766	Neural Tube Defects	1.2%
767	Paralysis, Obstetric	1.2%
768	Retinopathy of Prematurity	1.2%
769	Tethered Cord Syndrome	1.2%
770	Iniencephaly	1.2%
771	Craniorachischisis	1.2%
772	Limb Deformities, Congenital	1.2%
773	Exencephaly	1.2%
774	Septo-Optic Dysplasia	1.2%
775	Craniofacial Abnormalities	1.2%
776	Cortical Dysplasia	1.2%
777	Malformations of Cortical Development	1.2%
778	Bloom Syndrome	1.2%
779	Bronchopulmonary Dysplasia	1.2%
780	Poland Syndrome	1.1%
781	Blepharophimosis	1.1%
782	Laryngostenosis	1.1%
783	Mouth Abnormalities	1.1%
784	Respiratory Distress Syndrome, Newborn	1.1%
785	Horseshoe Kidney	1.1%
786	Pectus excavatum	1.1%
787	Klippel-Feil Syndrome	1.1%
788	Gastroschisis	1.1%
789	Synostosis	1.1%
790	Acrodermatitis	1.1%
791	Lymphangiectasis, Intestinal	1.1%
792	Gianotti-Crosti Syndrome	1.1%
793	Micrognathism	1%
794	Pierre Robin Syndrome	1%
795	Arthrogryposis	1%
796	Choanal Atresia	1%
797	Tracheobronchomegaly	1%
798	Laryngocele	1%
799	Hermaphroditism	1%
800	Disorders of Sex Development	1%
801	Cryptorchidism	1%
802	Hypospadias	1%
803	Dandy-Walker Syndrome	1%
804	Leukomalacia, Periventricular	1%
805	POEMS Syndrome	1%
806	Retrognathia	1%
807	Laryngomalacia	0.9%
808	Hyperandrogenism	0.9%
809	Pectus carinatum	0.9%
810	Bladder Exstrophy	0.9%
811	Epispadias	0.9%
812	Multicystic Dysplastic Kidney	0.9%
813	Prognathism	0.9%
814	Amelia	0.9%
815	Arachnodactyly	0.9%
816	Ectopia Cordis	0.9%
817	Ectromelia	0.9%
818	Hemimelia	0.9%
819	Meningomyelocele	0.9%
820	Phocomelia	0.9%
821	Sirenomelia	0.9%
822	Spina Bifida	0.9%
823	Polydactyly	0.9%
824	Brachydactyly	0.9%
825	Plagiocephaly	0.9%
826	Lower Extremity Deformities, Congenital	0.9%
827	Upper Extremity Deformities, Congenital	0.9%
828	Single umbilical artery	0.9%
829	Kernicterus	0.9%
830	Aortic coarctation	0.8%
831	Cor Triatriatum	0.8%
832	Coronary Vessel Anomalies	0.8%
833	Dental Enamel Hypoplasia	0.8%
834	Patent ductus arteriosus	0.8%
835	Ebstein Anomaly	0.8%
836	Heart Septal Defects	0.8%
837	Hyaline Membrane Disease	0.8%
838	Hypodontia	0.8%
839	Macrostomia	0.8%
840	Meningocele	0.8%
841	Microstomia	0.8%
842	Tetralogy of Fallot	0.8%
843	Transposition of Great Vessels	0.8%
844	Hypoplastic Left Heart Syndrome	0.8%
845	May-Thurner Syndrome	0.8%
846	Encephalocele	0.8%
847	Craniofacial Dysostosis	0.8%
848	Wolff-Parkinson-White Syndrome	0.8%
849	Long QT Syndrome	0.8%
850	Platybasia	0.8%
851	Tricuspid Atresia	0.8%
852	Arrhythmogenic Right Ventricular Dysplasia	0.8%
853	Gonadal Dysgenesis	0.7%
854	Bronchomalacia	0.7%
855	Adrenogenital Syndrome	0.7%
856	Tracheomalacia	0.7%
857	Ovotesticular Disorders of Sex Development	0.7%
858	Dermal Sinus	0.7%
859	Spina Bifida Cystica	0.7%
860	Spina Bifida Occulta	0.7%
861	Lissencephaly	0.7%
862	Polymicrogyria	0.7%
863	Pachygyria	0.7%
864	Schizencephaly	0.7%
865	Periventricular Nodular Heterotopia	0.7%
866	Aortopulmonary Septal Defect	0.7%
867	Double Outlet Right Ventricle	0.7%
868	Endocardial Cushion Defects	0.7%
869	Myocardial bridging	0.7%
870	Aorticopulmonary Septal Defect	0.7%
871	Mandibulofacial Dysostosis	0.6%
872	Romano-Ward Syndrome	0.6%
873	Truncus Arteriosus, Persistent	0.6%
874	Goldenhar Syndrome	0.6%
875	Talipes	0.6%
876	Arteriovenous fistula	0.5%
877	Congenital clubfoot	0.5%
878	Vertical Talus	0.5%

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