MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Platybasia

(UMLS:C0032209)

Definition:: A developmental deformity of the occipital bone and upper end of the cervical spine, in which the latter appears to have pushed the floor of the occipital bone upward. (Dorland, 27th ed)
UMLS ID:: C0032209
MeSH ID:: D010985

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.742|C05.116.900.540|C05.660.207.720

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.621.207.720

Synonym(s)

Platybasia

Basilar impression

Flat base of skull

Increased basal angle of skull base

Obtuse basal angle of skull base

platybasia

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Alendronate	FAERS: 1	US FAERS
2	rofecoxib	FAERS: 1	OFFSIDES US FAERS
3	Albuterol		OFFSIDES
4	Cephalexin		OFFSIDES
5	Cetirizine		OFFSIDES
6	Clonazepam		OFFSIDES
7	Estradiol		OFFSIDES
8	Fluticasone		OFFSIDES
9	Fluticasone		OFFSIDES
10	Gatifloxacin		OFFSIDES
11	Meloxicam		OFFSIDES
12	Methylprednisolone		OFFSIDES
13	Prednisone		OFFSIDES
14	Progesterone		OFFSIDES
15	Valsartan		OFFSIDES
16	cefpodoxime proxetil		OFFSIDES
17	cefpodoxime		OFFSIDES
18	nefazodone		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Craniofacial Dysostosis	46.5%
2	Craniosynostosis	46.4%
3	Brachycephaly	46.4%
4	Pectus excavatum	45.5%
5	Pectus carinatum	42.3%
6	Acrocephalosyndactylia	40.4%
7	Klippel-Feil Syndrome	40%
8	Synostosis	40%
9	Arthrogryposis	37%
10	Plagiocephaly	36.3%
11	Rubinstein-Taybi Syndrome	35.9%
12	Syndactyly	34.8%
13	Gigantism	34.1%
14	Spinal Neoplasms	34.1%
15	Spondylitis	34.1%
16	Osteoarthropathy, Secondary Hypertrophic	33.9%
17	Mandibulofacial Dysostosis	31.4%
18	Maxillofacial Abnormalities	31.2%
19	Goldenhar Syndrome	30.6%
20	Dysostoses	29.1%
21	Spinal Stenosis	29.1%
22	Spondylosis	29.1%
23	Intervertebral Disc Degeneration	29.1%
24	Osteochondritis	29%
25	Microcephaly	28.8%
26	Macrocephaly	28.8%
27	Limb Deformities, Congenital	28.5%
28	Hyperostosis	28.2%
29	Osteitis	28.2%
30	Osteitis Deformans	28.2%
31	Osteochondrosis	28.2%
32	Holoprosencephaly	27.9%
33	Multiple Epiphyseal Dysplasia	27.4%
34	Osteochondrodysplasias	27.4%
35	Poland Syndrome	27.3%
36	Discitis	25.2%
37	Jaw Abnormalities	24.5%
38	Gastroschisis	24.3%
39	Bone Diseases, Endocrine	24.3%
40	Dwarfism	24.1%
41	Noonan Syndrome	23.9%
42	Bone Diseases, Infectious	23.7%
43	Bone neoplasms	23.7%
44	Osteopenia	23.7%
45	Congenital Hypothyroidism	23.7%
46	Osteoarthritis, Spine	23.5%
47	Bone Resorption	23.5%
48	Aseptic Necrosis of Bone	23.5%
49	Antley-Bixler Syndrome Phenotype	23%
50	Tuberculosis, Spinal	22%
51	Porencephaly	22%
52	Chondrodysplasia Punctata	21.7%
53	Enchondromatosis	21.7%
54	Lordosis	21.7%
55	Osteosclerosis	21.7%
56	Spondylolysis	21.7%
57	kyphosis	21.7%
58	Kashin-Beck Disease	21.7%
59	Fasciitis	20.7%
60	Foot Deformities	20.7%
61	Arthropathy	20.7%
62	Ankylosing spondylitis	20.7%
63	Contracture	20.3%
64	Fasciitis, Plantar	20.3%
65	Spondylarthropathies	19.9%
66	Marfan Syndrome	19.5%
67	Prognathism	19%
68	Micrognathism	18.8%
69	Pierre Robin Syndrome	18.8%
70	Amelia	18.7%
71	Arachnodactyly	18.7%
72	Ectromelia	18.7%
73	Hemimelia	18.7%
74	Phocomelia	18.7%
75	Sirenomelia	18.7%
76	Polydactyly	18.7%
77	Brachydactyly	18.7%
78	Lower Extremity Deformities, Congenital	18.7%
79	Upper Extremity Deformities, Congenital	18.7%
80	Ainhum	18.5%
81	Talipes	18.5%
82	Osteogenesis Imperfecta	18.1%
83	Arthritis, Psoriatic	18%
84	Melorheostosis	18%
85	Osteopetrosis	18%
86	Spondylolisthesis	18%
87	Jaw Diseases	17.8%
88	Fibromyalgia	17.4%
89	Polymyalgia Rheumatica	17.4%
90	Cartilage Diseases	17.3%
91	Foot Diseases	17.3%
92	Myopathy	17.3%
93	Rheumatism	17.3%
94	Chondromalacia	17.3%
95	Metatarsalgia	17.3%
96	Retrognathia	17.1%
97	Arthritis, Reactive	16.8%
98	Platybasia	16.5%
99	Basal Cell Nevus Syndrome	16.4%
100	Gout	16.2%
101	Bone Diseases, Developmental	16.1%
102	Spinal Diseases	16.1%
103	Cleft Palate	16%
104	Cockayne Syndrome	15.9%
105	Osteomyelitis	15.5%
106	Osteoporosis	15.5%
107	Periostitis	15.5%
108	Bone Demineralization, Pathologic	15.5%
109	Post-Traumatic Osteoporosis	15.5%
110	Eosinophilic Granuloma	15.4%
111	Alveolar Bone Loss	15.4%
112	Femur Head Necrosis	15.4%
113	Osteolysis	15.4%
114	Congenital clubfoot	15.1%
115	Vertical Talus	15.1%
116	Ischemic contracture	14.9%
117	Temporomandibular Joint Disorders	14.7%
118	Laryngomalacia	14.7%
119	Rheumatic Fever	14.3%
120	Nail-Patella Syndrome	13.5%
121	Temporomandibular Joint Dysfunction Syndrome	13.4%
122	Hip Contracture	13.3%
123	Periarthritis	13.3%
124	Acromegaly	13.2%
125	Joint Tuberculosis	13.2%
126	Tuberculosis, Osteoarticular	13.2%
127	Bone Tuberculosis	13.2%
128	Rheumatoid Arthritis	12.7%
129	Juvenile arthritis	12.7%
130	Arthritis	12.1%
131	Bursitis	12.1%
132	Joint Instability	12.1%
133	Myofascial Pain Syndromes	12.1%
134	Rhabdomyolysis	12.1%
135	Synovitis	12.1%
136	Joint laxity	12.1%
137	Polyarthritis	12.1%
138	Frozen shoulder	12.1%
139	Patellofemoral Pain Syndrome	12.1%
140	Osteoarthritis, Knee	11.5%
141	Rickets	11.5%
142	Osteoporosis, Postmenopausal	11.5%
143	Arthritis, Gouty	11.4%
144	Pseudohypoparathyroidism	11%
145	Bronchomalacia	10.7%
146	Tracheomalacia	10.7%
147	Compartment syndromes	10.2%
148	Maxillary Diseases	10.2%
149	Tendinitis	10.2%
150	Tendinopathy	10.2%
151	Abnormalities, Drug-Induced	10.1%
152	Situs Inversus	10.1%
153	Hemarthrosis	10.1%
154	Myositis	10.1%
155	Tietze's Syndrome	10.1%
156	Isaacs syndrome	10.1%
157	Myotonic Disorders	10.1%
158	Beckwith-Wiedemann Syndrome	10%
159	Wolf-Hirschhorn Syndrome	10%
160	Rheumatoid Nodule	9.9%
161	Mastoiditis	9.8%
162	Petrositis	9.8%
163	Palatal Neoplasms	9.7%
164	Aicardi's syndrome	9.1%
165	Smith-Magenis syndrome	8.8%
166	Medial Tibial Stress Syndrome	8.7%
167	Cri-du-Chat Syndrome	8.7%
168	Down Syndrome	8.7%
169	Trisomy 21	8.7%
170	Eye Abnormalities	8.7%
171	Cardiovascular Abnormalities	8.7%
172	Felty Syndrome	8.6%
173	Mitochondrial Myopathies	8.6%
174	Muscle Cramp	8.6%
175	Eosinophilia-Myalgia Syndrome	8.6%
176	Osteomalacia	8.5%
177	Muscle Rigidity	8.5%
178	Muscle Spasticity	8.5%
179	Cogwheel Rigidity	8.5%
180	Nuchal Rigidity	8.5%
181	Skin Abnormalities	8.5%
182	Lymphatic Abnormalities	8.5%
183	Congenital Microtia	8.5%
184	Congenital diaphragmatic hernia	8.3%
185	Familial Periodic Paralysis	8.3%
186	Muscular Dystrophy	8.1%
187	Myotonic Dystrophy	8.1%
188	Bunion	7.9%
189	Fibrodysplasia Ossificans Progressiva	7.9%
190	Myoglobinuria	7.9%
191	Myositis Ossificans	7.9%
192	Tenosynovitis	7.9%
193	Sacroiliitis	7.9%
194	Chronic Fatigue Syndrome	7.8%
195	Ectodermal Dysplasia	7.7%
196	Aplasia Cutis Congenita	7.7%
197	Prader-Willi Syndrome	7.7%
198	Rheumatoid Vasculitis	7.7%
199	Giant Cell Epulis	7.6%
200	Muscle Weakness	7.6%
201	Musculoskeletal Pain	7.5%
202	Urogenital Abnormalities	7.5%
203	Arthralgia	7.4%
204	Polyarthralgia	7.4%
205	Anencephaly	7.1%
206	Sicca Syndrome	6.9%
207	Sjogren's Syndrome	6.9%
208	Bone Diseases	6.9%
209	Arthritis, Infectious	6.7%
210	Craniofacial Abnormalities	6.7%
211	CHARGE Syndrome	6.7%
212	Anterior Compartment Syndrome	6.6%
213	Enthesopathy	6.6%
214	Arthritis, Experimental	6.6%
215	Abdominal Compartment Syndrome	6.6%
216	Myalgia	6.6%
217	Polymyositis	6.6%
218	Kartagener Syndrome	6.5%
219	Nose Neoplasms	6.4%
220	Dural Arteriovenous Fistula	6.2%
221	Renal Osteodystrophy	6.2%
222	Renal rickets	6.2%
223	Genetic Diseases, Inborn	6.2%
224	Dextrocardia	6.2%
225	Myotonia Congenita	6.2%
226	Muscular Dystrophy, Duchenne	6.2%
227	Prune Belly Syndrome	6%
228	Twins, Conjoined	6%
229	Waardenburg Syndrome	6%
230	Xeroderma	5.9%
231	Mobius Syndrome	5.9%
232	Hip Dislocation	5.8%
233	Shoulder Dislocation	5.8%
234	Hip Dysplasia	5.8%
235	Orbital Myositis	5.7%
236	Dupuytren Contracture	5.7%
237	Pyomyositis	5.7%
238	Welander Distal Myopathy	5.6%
239	Abnormalities, Radiation-Induced	5.5%
240	Hypokalemic periodic paralysis	5.5%
241	Fetal Diseases	5.2%
242	Scimitar Syndrome	5.1%
243	Anophthalmos	5%
244	Anus, Imperforate	5%
245	Hydranencephaly	5%
246	Microphthalmos	5%
247	Neural Tube Defects	5%
248	Tethered Cord Syndrome	5%
249	Iniencephaly	5%
250	Craniorachischisis	5%
251	Exencephaly	5%
252	Septo-Optic Dysplasia	5%
253	Cortical Dysplasia	5%
254	Malformations of Cortical Development	5%
255	Anorectal Malformations	5%
256	Bloom Syndrome	5%
257	Polycystic Kidney Diseases	4.9%
258	Williams Syndrome	4.9%
259	Shoulder Pain	4.9%
260	Alstrom Syndrome	4.8%
261	Retinal Dysplasia	4.5%
262	Aniridia	4.5%
263	Epidermolysis Bullosa	4.4%
264	Mitochondrial Encephalomyopathies	4.4%
265	Blepharophimosis	4.3%
266	Laryngostenosis	4.3%
267	Mouth Abnormalities	4.3%
268	Fragile X Syndrome	4.3%
269	Esophageal Atresia	4.3%
270	Intestinal Atresia	4.3%
271	Horseshoe Kidney	4.3%
272	Ichthyosis, X-Linked	4.3%
273	Cystic Fibrosis	4.3%
274	Acrodermatitis	4.3%
275	Lymphangiectasis, Intestinal	4.3%
276	Gianotti-Crosti Syndrome	4.3%
277	Smith-Lemli-Opitz Syndrome	4.2%
278	Familial Hypophosphatemic Rickets	4.1%
279	Turner Syndrome	4%
280	Primary Ciliary Dyskinesia	3.9%
281	Choanal Atresia	3.8%
282	Tracheobronchomegaly	3.8%
283	Laryngocele	3.8%
284	Choledochal Cyst	3.8%
285	Hermaphroditism	3.8%
286	Disorders of Sex Development	3.8%
287	Meconium Aspiration Syndrome	3.8%
288	Cryptorchidism	3.8%
289	Hypospadias	3.8%
290	Dermatomyositis	3.8%
291	Central Nervous System Cysts	3.7%
292	Dandy-Walker Syndrome	3.7%
293	POEMS Syndrome	3.7%
294	Classical Lissencephalies and Subcortical Band Heterotopias	3.7%
295	Pseudoxanthoma Elasticum	3.6%
296	Sjogren-Larsson Syndrome	3.4%
297	Abdominal Cramps	3.4%
298	Amniotic Band Syndrome	3.4%
299	Asphyxia Neonatorum	3.4%
300	Infant, Premature, Diseases	3.4%
301	Infantile Colic	3.4%
302	Xeroderma Pigmentosum	3.3%
303	Bladder Exstrophy	3.3%
304	Epispadias	3.3%
305	Multicystic Dysplastic Kidney	3.3%
306	Ectopia Cordis	3.3%
307	Meningomyelocele	3.3%
308	Spina Bifida	3.3%
309	Single umbilical artery	3.3%
310	Polycystic Kidney, Autosomal Dominant	3.2%
311	Kallmann Syndrome	3.1%
312	Klinefelter Syndrome	3.1%
313	Zellweger Syndrome	3%
314	Charcot-Marie-Tooth Disease	2.9%
315	Neoplastic Syndromes, Hereditary	2.9%
316	Aortic coarctation	2.8%
317	Cor Triatriatum	2.8%
318	Coronary Vessel Anomalies	2.8%
319	Dental Enamel Hypoplasia	2.8%
320	Patent ductus arteriosus	2.8%
321	Ebstein Anomaly	2.8%
322	Heart Septal Defects	2.8%
323	Hypodontia	2.8%
324	Macrostomia	2.8%
325	Meningocele	2.8%
326	Microstomia	2.8%
327	Tetralogy of Fallot	2.8%
328	Transposition of Great Vessels	2.8%
329	Hypoplastic Left Heart Syndrome	2.8%
330	May-Thurner Syndrome	2.8%
331	Encephalocele	2.8%
332	Wolff-Parkinson-White Syndrome	2.8%
333	Anemia, Neonatal	2.8%
334	Pelger-Huet Anomaly	2.8%
335	Persistent Fetal Circulation Syndrome	2.8%
336	Werner Syndrome	2.8%
337	Myasthenic Syndromes, Congenital	2.8%
338	Umbilical hernia	2.8%
339	Hyperkeratosis, Epidermolytic	2.8%
340	MELAS Syndrome	2.7%
341	Tuberous Sclerosis	2.7%
342	Radicular Cyst	2.7%
343	Refsum Disease	2.6%
344	Long QT Syndrome	2.5%
345	Tricuspid Atresia	2.5%
346	Arrhythmogenic Right Ventricular Dysplasia	2.5%
347	Anemia, Sickle Cell	2.5%
348	Thalassemia	2.5%
349	Gonadal Dysgenesis	2.5%
350	Adrenogenital Syndrome	2.5%
351	Ovotesticular Disorders of Sex Development	2.5%
352	Dermal Sinus	2.5%
353	Spina Bifida Cystica	2.5%
354	Spina Bifida Occulta	2.5%
355	Lissencephaly	2.5%
356	Polymicrogyria	2.5%
357	Pachygyria	2.5%
358	Schizencephaly	2.5%
359	Periventricular Nodular Heterotopia	2.5%
360	Neonatal Abstinence Syndrome	2.4%
361	Hyperandrogenism	2.4%
362	Albinism	2.4%
363	Fetal Growth Retardation	2.4%
364	Fetal Hypoxia	2.4%
365	Congenital nystagmus	2.4%
366	Fetal Alcohol Spectrum Disorders	2.4%
367	Toxoplasmosis, Congenital	2.4%
368	Syphilis, Congenital	2.4%
369	Autoimmune Lymphoproliferative Syndrome	2.1%
370	Aortopulmonary Septal Defect	2.1%
371	Double Outlet Right Ventricle	2.1%
372	Endocardial Cushion Defects	2.1%
373	Myocardial bridging	2.1%
374	Aorticopulmonary Septal Defect	2.1%
375	Congenital Hyperinsulinism	2.1%
376	Chorioamnionitis	2.1%
377	Kearns-Sayre syndrome	2.1%
378	Angioedemas, Hereditary	2.1%
379	Familial Mediterranean Fever	2%
380	Wiskott-Aldrich Syndrome	2%
381	Mucopolysaccharidosis II	1.9%
382	Rett Syndrome	1.9%
383	Menkes Kinky Hair Syndrome	1.9%
384	Romano-Ward Syndrome	1.8%
385	Truncus Arteriosus, Persistent	1.7%
386	Paralysis, Obstetric	1.7%
387	Retinopathy of Prematurity	1.7%
388	Amino Acid Metabolism, Inborn Errors	1.7%
389	Carbohydrate Metabolism, Inborn Errors	1.7%
390	Metal Metabolism, Inborn Errors	1.7%
391	Progeria	1.7%
392	Lysosomal Storage Diseases	1.7%
393	Cytochrome-c Oxidase Deficiency	1.7%
394	Peroxisomal Disorders	1.7%
395	Bronchopulmonary Dysplasia	1.6%
396	Ophthalmia Neonatorum	1.6%
397	Neuronal Ceroid-Lipofuscinoses	1.6%
398	Sickle Cell Trait	1.6%
399	Adrenoleukodystrophy	1.5%
400	Hepatolenticular Degeneration	1.5%
401	Ataxia Telangiectasia	1.5%
402	Amyloid Neuropathies, Familial	1.5%
403	Arteriovenous fistula	1.5%
404	Respiratory Distress Syndrome, Newborn	1.4%
405	Cutis Laxa	1.4%
406	Retinitis Pigmentosa	1.4%
407	Pigmentary retinopathy	1.4%
408	Porokeratosis	1.4%
409	Keratoderma, Palmoplantar	1.4%
410	Chronic granulomatous disease	1.4%
411	Fabry Disease	1.4%
412	Hydrops Fetalis	1.4%
413	Acute Chest Syndrome	1.3%
414	Denys-Drash Syndrome	1.3%
415	Galactosemias	1.3%
416	Urea Cycle Disorders, Inborn	1.3%
417	Tyrosinemias	1.3%
418	Duane Retraction Syndrome	1.3%
419	Porphyrias, Hepatic	1.3%
420	Peutz-Jeghers Syndrome	1.2%
421	Thrombasthenia	1.2%
422	Antithrombin III Deficiency	1.2%
423	Protein C Deficiency	1.2%
424	Brain Diseases, Metabolic, Inborn	1.2%
425	Afibrinogenemia	1.2%
426	Dystonia Musculorum Deformans	1.2%
427	Factor VII Deficiency	1.2%
428	Factor X Deficiency	1.2%
429	Factor XII Deficiency	1.2%
430	Hemophilia A	1.2%
431	Leukomalacia, Periventricular	1.2%
432	Activated Protein C Resistance	1.2%
433	Factor II deficiency	1.2%
434	Factor VIII Deficiency	1.2%
435	Factor V deficiency	1.2%
436	Factor XI Deficiency	1.2%
437	Hypoprothrombinemias	1.2%
438	Fanconi Anemia	1.2%
439	Nesidioblastosis	1.2%
440	Lafora Disease	1.2%
441	Unverricht-Lundborg Syndrome	1.2%
442	Anemia, Diamond-Blackfan	1.2%
443	Canavan Disease	1.2%
444	Alexander Disease	1.2%
445	Glycogen storage disease type II	1.2%
446	Optic Atrophy, Hereditary, Leber	1.2%
447	Hyperphosphaturia	1.2%
448	Multiple Endocrine Neoplasia	1.1%
449	Dermatitis, Atopic	1.1%
450	Alkaptonuria	1.1%
451	Glycogen Storage Disease	1.1%
452	Hypophosphatasia	1.1%
453	Propionic acidemia	1.1%
454	Dihydropyrimidine Dehydrogenase Deficiency	1.1%
455	Cystinosis	1.1%
456	Mucopolysaccharidosis III	1.1%
457	Homocystinuria	1%
458	Leigh Disease	1%
459	Kernicterus	1%
460	Behcet Syndrome	1%
461	Hyaline Membrane Disease	0.9%
462	Hypolipoproteinemias	0.9%
463	Papillon-Lefevre Disease	0.9%
464	Hyperlipidemia, Familial Combined	0.9%
465	Hyperlipoproteinemia Type III	0.9%
466	Gaucher Disease	0.9%
467	Huntington Disease	0.9%
468	Carbamoyl-Phosphate Synthase I Deficiency Disease	0.9%
469	Nephroblastoma	0.8%
470	Lactose Intolerance	0.8%
471	Variegate Porphyria	0.8%
472	Acute intermittent porphyria	0.8%
473	Porphyria Cutanea Tarda	0.8%
474	Hyperhomocysteinemia	0.8%
475	Glycogen Storage Disease Type I	0.8%
476	Glycogen Storage Disease Type V	0.8%
477	Renal Aminoacidurias	0.8%
478	Fanconi Syndrome	0.8%
479	Pseudohypoaldosteronism	0.8%
480	Liddle Syndrome	0.8%
481	Hyperlipoproteinemia Type IV	0.8%
482	Hyperlipoproteinemia Type V	0.8%
483	Tay-Sachs Disease	0.8%
484	Niemann-Pick Disease, Type C	0.8%
485	Adenomatous Polyposis Coli	0.8%
486	Multiple Endocrine Neoplasia Type 1	0.7%
487	Friedreich Ataxia	0.7%
488	Renal tubular acidosis	0.7%
489	Hypoalphalipoproteinemias	0.7%
490	Cystinuria	0.6%
491	Glycosuria, Renal	0.6%

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