MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperhomocysteinemia

(UMLS:C0598608)

Definition:: Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 渭mol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
UMLS ID:: C0598608
MeSH ID:: D020138

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.100.480

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.603.378|C18.452.648.100.480|C18.654.521.500.133.699.418

Synonym(s)

Hyperhomocysteinemia

Hyperhomocysteinaemia

hyperhomocysteinaemia

hyperhomocysteinemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Carbamazepine	10459572	CTD
2	Catechin	17292331	CTD
3	Dizocilpine Maleate	20406136	CTD
4	Folic Acid	View details 11598393 15493348 15847747 16395265 16397167 16433478 16755160 16865747 20116427 20406136 21893018 22647887	CTD
5	Glutathione	20413874	CTD
6	Homocysteine	View details 17292331 17369066 18234410 19028542	CTD
7	Isotretinoin	20236286	CTD
8	Levodopa	16275827 16787708	CTD
9	Melatonin	16181111	CTD
10	Methionine	View details 15870546 15882843 16181111 16213988 16841179 18520950 20406136 27228698 27900820	CTD
11	Methotrexate	18551038 19449473	CTD
12	Niacin	11895163	CTD
13	Norethindrone Acetate	18786290	CTD
14	Phenytoin	10459572	CTD
15	Resveratrol	19028542	CTD
16	Simvastatin	18224302	CTD
17	Vitamin B 12	9710054 12598836 16397167	CTD
18	Vitamin B 6	16397167	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Urea Cycle Disorders, Inborn	40.2%
2	Tyrosinemias	40.2%
3	Alkaptonuria	37.8%
4	Propionic acidemia	37.8%
5	Carbamoyl-Phosphate Synthase I Deficiency Disease	34.5%
6	Wasting Syndrome	33.9%
7	Brain Diseases, Metabolic, Inborn	32.5%
8	Lactose Intolerance	31.4%
9	Leigh Disease	31.4%
10	Smith-Lemli-Opitz Syndrome	31%
11	Pseudohypoparathyroidism	30.7%
12	Carbohydrate Metabolism, Inborn Errors	30.6%
13	Metal Metabolism, Inborn Errors	30.6%
14	Progeria	30.6%
15	Lysosomal Storage Diseases	30.6%
16	Peroxisomal Disorders	30.6%
17	Galactosemias	29.9%
18	Hyperphosphaturia	27.2%
19	Glycogen storage disease type II	26.7%
20	Rickets	26.7%
21	Albinism	26.4%
22	Hypercalcemia	25.3%
23	Hypocalcemia	25.3%
24	Milk-Alkali Syndrome	25.3%
25	Hypolipoproteinemias	25.1%
26	Acid-Base Imbalance	24.5%
27	Calcium Metabolism Disorders	24.5%
28	Iron Metabolism Disorders	24.5%
29	Phosphorus Metabolism Disorders	24.5%
30	Water-Electrolyte Imbalance	24.5%
31	Lipid Metabolism Disorders	24.5%
32	Mitochondrial Diseases	24.5%
33	Glucose Metabolism Disorders	24.5%
34	Familial Hypophosphatemic Rickets	24.3%
35	Hyperlipoproteinemia Type IV	24.2%
36	Hyperlipoproteinemia Type V	24.2%
37	Menkes Kinky Hair Syndrome	24.1%
38	Cytochrome-c Oxidase Deficiency	24.1%
39	Gaucher Disease	23.9%
40	Adrenoleukodystrophy	23.6%
41	Hyperlipidemia, Familial Combined	23.5%
42	Hyperlipoproteinemia Type III	22.6%
43	Folic Acid Deficiency	22.5%
44	Pellagra	22.5%
45	Thiamine Deficiency	22.5%
46	Vitamin B 12 Deficiency	22.5%
47	Vitamin B 6 Deficiency	22.5%
48	Pyridoxine Deficiency	22.5%
49	Zellweger Syndrome	22.3%
50	Hepatolenticular Degeneration	22.2%
51	Lipodystrophy	21.8%
52	Refsum Disease	21.7%
53	Amyloid Neuropathies, Familial	21.4%
54	Fabry Disease	21.3%
55	Celiac Disease	21.2%
56	Sprue, Tropical	21.2%
57	Steatorrhea	21.2%
58	Sprue	21.2%
59	Werner Syndrome	21%
60	Mucopolysaccharidosis III	20.8%
61	Osteopenia	20.7%
62	Glycogen Storage Disease	20.6%
63	Hypophosphatasia	20.6%
64	Dihydropyrimidine Dehydrogenase Deficiency	20.6%
65	Cystinosis	20.6%
66	Brain Diseases, Metabolic	20.5%
67	Tay-Sachs Disease	20.4%
68	Niemann-Pick Disease, Type C	20%
69	Neuronal Ceroid-Lipofuscinoses	19.6%
70	Renal tubular acidosis	19.5%
71	Hypoalphalipoproteinemias	19.2%
72	Osteomalacia	19.1%
73	Mucopolysaccharidosis II	18.8%
74	Homocystinuria	18.5%
75	Wernicke Encephalopathy	18.1%
76	Ascorbic Acid Deficiency	17.6%
77	Vitamin A Deficiency	17.6%
78	Vitamin D Deficiency	17.6%
79	Vitamin E Deficiency	17.6%
80	Beriberi	17.3%
81	MELAS Syndrome	16.6%
82	Glycosuria, Renal	15.9%
83	Familial Periodic Paralysis	15.7%
84	Glycogen Storage Disease Type I	15.7%
85	Glycogen Storage Disease Type V	15.7%
86	Child Nutrition Disorders	15.7%
87	Hypervitaminosis A	15.7%
88	Infant Nutrition Disorders	15.7%
89	Congenital Hyperinsulinism	15.5%
90	Renal Aminoacidurias	15.4%
91	Fanconi Syndrome	15.4%
92	Pseudohypoaldosteronism	15.4%
93	Liddle Syndrome	15.4%
94	Ichthyosis, X-Linked	15.4%
95	Magnesium Deficiency	15.3%
96	Potassium Deficiency	15.3%
97	Protein Deficiency	15.3%
98	Acidosis	15.1%
99	Alkalosis	15.1%
100	Amyloidosis	15.1%
101	Calcinosis	15.1%
102	Hyperglycemia	15.1%
103	Hyperinsulinism	15.1%
104	Hyperkalemia	15.1%
105	Hypernatremia	15.1%
106	Hypoglycemia	15.1%
107	Hypokalemia	15.1%
108	Hyponatremia	15.1%
109	Xanthomatosis	15.1%
110	Hypophosphatemia	15.1%
111	Metabolic acidosis	15.1%
112	Dyslipidemias	15.1%
113	Iron Overload	15.1%
114	Xanthoma	15.1%
115	Sjogren-Larsson Syndrome	14.8%
116	Starvation	14.8%
117	Refeeding Syndrome	14.8%
118	Cockayne Syndrome	14.5%
119	Antley-Bixler Syndrome Phenotype	14.5%
120	Anemia, Pernicious	14.4%
121	Bloom Syndrome	14.3%
122	Mitochondrial Encephalomyopathies	14.3%
123	Gout	14%
124	Renal Osteodystrophy	13.9%
125	Renal rickets	13.9%
126	Canavan Disease	13.7%
127	Alexander Disease	13.7%
128	Diabetic Ketoacidosis	13.4%
129	HIV Wasting Syndrome	13.4%
130	Porphyrias, Hepatic	13.3%
131	Diabetes Mellitus	13.1%
132	Fanconi Anemia	13.1%
133	Nutrition Disorders	12.9%
134	Dehydration	12.8%
135	Lipomatosis	12.8%
136	Water Intoxication	12.8%
137	Vitamin K Deficiency	12.7%
138	Achlorhydria	12.7%
139	Osteoporosis	12.7%
140	Bone Demineralization, Pathologic	12.7%
141	Post-Traumatic Osteoporosis	12.7%
142	Hypokalemic periodic paralysis	11.8%
143	Cystinuria	11.7%
144	Nesidioblastosis	11.6%
145	Ataxia Telangiectasia	11.5%
146	Mitochondrial Myopathies	11%
147	Myelinolysis, Central Pontine	10.9%
148	Glycosuria	10.8%
149	Reye Syndrome	10.8%
150	Hepatic Encephalopathy	10.8%
151	Friedreich Ataxia	10.5%
152	HIV-Associated Lipodystrophy Syndrome	10.5%
153	Acidosis, Lactic	10.5%
154	Calciphylaxis	10.5%
155	Hemosiderosis	10.5%
156	Ketosis	10.5%
157	Ketonuria	10.5%
158	Ketoacidosis	10.5%
159	Ketonemia	10.5%
160	Vascular calcification	10.5%
161	Arthritis, Gouty	10.5%
162	Optic Atrophy, Hereditary, Leber	10.4%
163	Hyperhomocysteinemia	10.1%
164	Subacute Combined Degeneration	9.9%
165	Marasmus	9.8%
166	Xeroderma Pigmentosum	9.7%
167	Necrobiosis Lipoidica Diabeticorum	9.5%
168	Variegate Porphyria	9%
169	Acute intermittent porphyria	9%
170	Porphyria Cutanea Tarda	9%
171	Kwashiorkor	8.9%
172	Acidosis, Respiratory	8.8%
173	Adiposis Dolorosa	8.8%
174	Alkalosis, Respiratory	8.8%
175	Scurvy	8.8%
176	Insulin Resistance	8.7%
177	Osteoporosis, Postmenopausal	8.7%
178	Kernicterus	8.7%
179	Prader-Willi Syndrome	8.6%
180	Neoplastic Syndromes, Hereditary	8.5%
181	CHARGE Syndrome	8.5%
182	Cystic Fibrosis	8.5%
183	Aicardi's syndrome	8.3%
184	Kearns-Sayre syndrome	8.3%
185	Multiple Epiphyseal Dysplasia	8.3%
186	Osteochondrodysplasias	8.3%
187	Pelger-Huet Anomaly	8.3%
188	Myasthenic Syndromes, Congenital	8.3%
189	Hypercholesterolemia	8.2%
190	Hyperlipoproteinemias	8.2%
191	Hypertriglyceridemia	8.2%
192	Amino Acid Metabolism, Inborn Errors	7.8%
193	Gestational Diabetes	7.7%
194	Latent Autoimmune Diabetes in Adults	7.7%
195	Diabetes Mellitus, Experimental	7.6%
196	Nephrocalcinosis	7.5%
197	Tetany	7.5%
198	Nail-Patella Syndrome	7.5%
199	Cerebral Amyloid Angiopathy	7.5%
200	Anemia, Sickle Cell	7.3%
201	Thalassemia	7.3%
202	Muscular Dystrophy, Duchenne	7.3%
203	Dwarfism	7.3%
204	Malnutrition	7.2%
205	Fragile X Syndrome	7.2%
206	Muscular Dystrophy	7.1%
207	Osteogenesis Imperfecta	7.1%
208	Beckwith-Wiedemann Syndrome	7%
209	Wolf-Hirschhorn Syndrome	7%
210	Primary amyloidosis	6.6%
211	Autoimmune Lymphoproliferative Syndrome	6.3%
212	Alstrom Syndrome	6.2%
213	Smith-Magenis syndrome	6.2%
214	Cri-du-Chat Syndrome	6.1%
215	Down Syndrome	6.1%
216	Angioedemas, Hereditary	6.1%
217	Trisomy 21	6.1%
218	Deformity	6.1%
219	Marfan Syndrome	6%
220	Kartagener Syndrome	6%
221	Amyotrophic Lateral Sclerosis	5.9%
222	Wiskott-Aldrich Syndrome	5.9%
223	Familial Mediterranean Fever	5.9%
224	Holoprosencephaly	5.7%
225	Metabolic Diseases	5.6%
226	Obesity	5.5%
227	Rett Syndrome	5.5%
228	Ectodermal Dysplasia	5.5%
229	Aplasia Cutis Congenita	5.5%
230	Kallmann Syndrome	5.4%
231	Myotonic Dystrophy	5.3%
232	CREST Syndrome	5.3%
233	Frontotemporal dementia	5.1%
234	Fetal Diseases	5.1%
235	Rubinstein-Taybi Syndrome	5%
236	Tuberous Sclerosis	5%
237	Polycystic Kidney Diseases	4.9%
238	Williams Syndrome	4.9%
239	Sickle Cell Trait	4.8%
240	Primary Ciliary Dyskinesia	4.7%
241	Deficiency Diseases	4.6%
242	Retinal Dysplasia	4.5%
243	Aniridia	4.4%
244	Epidermolysis Bullosa	4.4%
245	Cutis Laxa	4.3%
246	Retinitis Pigmentosa	4.2%
247	Pigmentary retinopathy	4.2%
248	Porokeratosis	4.2%
249	Keratoderma, Palmoplantar	4.2%
250	Chronic granulomatous disease	4.2%
251	Welander Distal Myopathy	4.2%
252	Obesity, Abdominal	4%
253	Acute Chest Syndrome	3.9%
254	Duane Retraction Syndrome	3.8%
255	Meconium Aspiration Syndrome	3.7%
256	Peutz-Jeghers Syndrome	3.7%
257	Myotonia Congenita	3.7%
258	Thrombasthenia	3.7%
259	Antithrombin III Deficiency	3.7%
260	Protein C Deficiency	3.7%
261	Afibrinogenemia	3.7%
262	Dystonia Musculorum Deformans	3.7%
263	Factor VII Deficiency	3.7%
264	Factor X Deficiency	3.7%
265	Factor XII Deficiency	3.7%
266	Hemophilia A	3.7%
267	Activated Protein C Resistance	3.7%
268	Factor II deficiency	3.7%
269	Factor VIII Deficiency	3.7%
270	Factor V deficiency	3.7%
271	Factor XI Deficiency	3.7%
272	Hypoprothrombinemias	3.7%
273	Lafora Disease	3.6%
274	Unverricht-Lundborg Syndrome	3.6%
275	Anemia, Diamond-Blackfan	3.6%
276	Pseudoxanthoma Elasticum	3.6%
277	Pediatric Obesity	3.5%
278	Multiple Endocrine Neoplasia	3.4%
279	Xeroderma	3.3%
280	Mobius Syndrome	3.3%
281	Congenital Hypothyroidism	3.3%
282	Abdominal Cramps	3.3%
283	Abnormalities, Drug-Induced	3.3%
284	Amniotic Band Syndrome	3.3%
285	Asphyxia Neonatorum	3.3%
286	Infant, Premature, Diseases	3.3%
287	Situs Inversus	3.3%
288	Infantile Colic	3.3%
289	Dermatitis, Atopic	3.3%
290	Avitaminosis	3.2%
291	Polycystic Kidney, Autosomal Dominant	3.2%
292	Classical Lissencephalies and Subcortical Band Heterotopias	3.1%
293	Hyperkeratosis, Epidermolytic	3.1%
294	Basal Cell Nevus Syndrome	3%
295	Behcet Syndrome	3%
296	Charcot-Marie-Tooth Disease	2.9%
297	Eye Abnormalities	2.8%
298	Cardiovascular Abnormalities	2.8%
299	Skin Abnormalities	2.8%
300	Lymphatic Abnormalities	2.8%
301	Congenital Microtia	2.8%
302	Papillon-Lefevre Disease	2.8%
303	Anemia, Neonatal	2.8%
304	Persistent Fetal Circulation Syndrome	2.8%
305	Congenital diaphragmatic hernia	2.7%
306	Umbilical hernia	2.7%
307	Huntington Disease	2.7%
308	Urogenital Abnormalities	2.5%
309	Nephroblastoma	2.4%
310	Neonatal Abstinence Syndrome	2.4%
311	Fetal Growth Retardation	2.4%
312	Fetal Hypoxia	2.4%
313	Congenital nystagmus	2.4%
314	Fetal Alcohol Spectrum Disorders	2.4%
315	Toxoplasmosis, Congenital	2.3%
316	Anencephaly	2.3%
317	Syphilis, Congenital	2.3%
318	Adenomatous Polyposis Coli	2.2%
319	Hydrops Fetalis	2.2%
320	Klinefelter Syndrome	2.2%
321	Multiple Endocrine Neoplasia Type 1	2.2%
322	Turner Syndrome	2.1%
323	Chorioamnionitis	2.1%
324	Maxillofacial Abnormalities	2.1%
325	Dural Arteriovenous Fistula	2.1%
326	Dextrocardia	2%
327	Prune Belly Syndrome	2%
328	Twins, Conjoined	2%
329	Waardenburg Syndrome	2%
330	Abnormalities, Radiation-Induced	1.8%
331	Scimitar Syndrome	1.7%
332	Anophthalmos	1.7%
333	Anus, Imperforate	1.7%
334	Hydranencephaly	1.7%
335	Microphthalmos	1.7%
336	Neural Tube Defects	1.7%
337	Paralysis, Obstetric	1.7%
338	Retinopathy of Prematurity	1.7%
339	Tethered Cord Syndrome	1.7%
340	Iniencephaly	1.7%
341	Craniorachischisis	1.7%
342	Limb Deformities, Congenital	1.7%
343	Exencephaly	1.7%
344	Septo-Optic Dysplasia	1.7%
345	Craniofacial Abnormalities	1.7%
346	Cortical Dysplasia	1.7%
347	Malformations of Cortical Development	1.7%
348	Anorectal Malformations	1.7%
349	Ophthalmia Neonatorum	1.6%
350	Bronchopulmonary Dysplasia	1.6%
351	Denys-Drash Syndrome	1.5%
352	Craniosynostosis	1.4%
353	Syndactyly	1.4%
354	Brachycephaly	1.4%
355	Blepharophimosis	1.4%
356	Laryngostenosis	1.4%
357	Mouth Abnormalities	1.4%
358	Respiratory Distress Syndrome, Newborn	1.4%
359	Esophageal Atresia	1.4%
360	Intestinal Atresia	1.4%
361	Horseshoe Kidney	1.4%
362	Pectus excavatum	1.4%
363	Microcephaly	1.4%
364	Macrocephaly	1.4%
365	Klippel-Feil Syndrome	1.4%
366	Gastroschisis	1.4%
367	Synostosis	1.4%
368	Acrodermatitis	1.4%
369	Lymphangiectasis, Intestinal	1.4%
370	Gianotti-Crosti Syndrome	1.4%
371	Acrocephalosyndactylia	1.4%
372	Noonan Syndrome	1.3%
373	Arthrogryposis	1.3%
374	Choanal Atresia	1.3%
375	Tracheobronchomegaly	1.3%
376	Laryngocele	1.3%
377	Choledochal Cyst	1.3%
378	Hermaphroditism	1.3%
379	Disorders of Sex Development	1.3%
380	Cryptorchidism	1.2%
381	Hypospadias	1.2%
382	Central Nervous System Cysts	1.2%
383	Dandy-Walker Syndrome	1.2%
384	Leukomalacia, Periventricular	1.2%
385	POEMS Syndrome	1.2%
386	Porencephaly	1.2%
387	Cleft Palate	1.2%
388	Jaw Abnormalities	1.2%
389	Laryngomalacia	1.1%
390	Pectus carinatum	1.1%
391	Bladder Exstrophy	1.1%
392	Epispadias	1.1%
393	Multicystic Dysplastic Kidney	1.1%
394	Amelia	1.1%
395	Arachnodactyly	1.1%
396	Ectopia Cordis	1.1%
397	Ectromelia	1.1%
398	Hemimelia	1.1%
399	Meningomyelocele	1.1%
400	Phocomelia	1.1%
401	Sirenomelia	1.1%
402	Spina Bifida	1.1%
403	Polydactyly	1.1%
404	Brachydactyly	1.1%
405	Plagiocephaly	1.1%
406	Lower Extremity Deformities, Congenital	1.1%
407	Upper Extremity Deformities, Congenital	1.1%
408	Single umbilical artery	1.1%
409	Poland Syndrome	1.1%
410	Aortic coarctation	0.9%
411	Cor Triatriatum	0.9%
412	Coronary Vessel Anomalies	0.9%
413	Dental Enamel Hypoplasia	0.9%
414	Patent ductus arteriosus	0.9%
415	Ebstein Anomaly	0.9%
416	Heart Septal Defects	0.9%
417	Hyaline Membrane Disease	0.9%
418	Hypodontia	0.9%
419	Macrostomia	0.9%
420	Meningocele	0.9%
421	Microstomia	0.9%
422	Tetralogy of Fallot	0.9%
423	Transposition of Great Vessels	0.9%
424	Hypoplastic Left Heart Syndrome	0.9%
425	May-Thurner Syndrome	0.9%
426	Encephalocele	0.9%
427	Craniofacial Dysostosis	0.9%
428	Wolff-Parkinson-White Syndrome	0.9%
429	Micrognathism	0.9%
430	Pierre Robin Syndrome	0.9%
431	Long QT Syndrome	0.8%
432	Platybasia	0.8%
433	Tricuspid Atresia	0.8%
434	Arrhythmogenic Right Ventricular Dysplasia	0.8%
435	Gonadal Dysgenesis	0.8%
436	Bronchomalacia	0.8%
437	Adrenogenital Syndrome	0.8%
438	Tracheomalacia	0.8%
439	Ovotesticular Disorders of Sex Development	0.8%
440	Retrognathia	0.8%
441	Dermal Sinus	0.8%
442	Spina Bifida Cystica	0.8%
443	Spina Bifida Occulta	0.8%
444	Lissencephaly	0.8%
445	Polymicrogyria	0.8%
446	Pachygyria	0.8%
447	Schizencephaly	0.8%
448	Periventricular Nodular Heterotopia	0.8%
449	Hyperandrogenism	0.8%
450	Prognathism	0.7%
451	Aortopulmonary Septal Defect	0.7%
452	Double Outlet Right Ventricle	0.7%
453	Endocardial Cushion Defects	0.7%
454	Myocardial bridging	0.7%
455	Aorticopulmonary Septal Defect	0.7%
456	Mandibulofacial Dysostosis	0.6%
457	Romano-Ward Syndrome	0.6%
458	Truncus Arteriosus, Persistent	0.6%
459	Goldenhar Syndrome	0.6%
460	Talipes	0.5%
461	Arteriovenous fistula	0.5%
462	Congenital clubfoot	0.5%
463	Vertical Talus	0.5%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120262