MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Myelinolysis, Central Pontine

(UMLS:C0206083)

Definition:: A demyelinating condition affecting the PONS and characterized clinically by an acute progressive QUADRIPLEGIA; DYSARTHRIA; DYSPHAGIA; and alterations of consciousness. Pathologic features include prominent demyelination in the central PONS with sparing of axons and neurons. This condition is usually associated with systemic disorders such as HYPONATREMIA; chronic ALCOHOLISM; LIVER FAILURE; severe BURNS; malignant NEOPLASMS; hemorrhagic PANCREATITIS; HEMODIALYSIS; and SEPSIS. The rapid medical correction of hyponatremia has been cited as a cause of this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1125-6)
UMLS ID:: C0206083
MeSH ID:: D017590

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.163.560|C10.314.500

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.132.560

Synonym(s)

Myelinolysis, Central Pontine

Central Pontine Myelinolysis

Central pontine myelinolysis

MYELINOCLASIS, CENTRAL PONTINE

central pontine myelinolysis

central pontine myelinosis

myelinolysis; pontine, central

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Alcohols	25307574	CTD
2	Cyclophosphamide	18988633	CTD
3	Furosemide	2486385	CTD
4	Lithium	12630660 18599196	CTD
5	Methotrexate	17357801	CTD
6	Sodium	3704734	CTD
7	Tacrolimus	12819864 15919502	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Marchiafava-Bignami Disease	43.2%
2	Brain Diseases, Metabolic, Inborn	35.7%
3	Reye Syndrome	35%
4	Hepatic Encephalopathy	34.8%
5	Mitochondrial Encephalomyopathies	32.6%
6	Meningoencephalitis	28.4%
7	Canavan Disease	27.6%
8	Alexander Disease	27.6%
9	Wernicke Encephalopathy	26.9%
10	Multiple System Atrophy	26.9%
11	Adrenoleukodystrophy	26.6%
12	Encephalomyelitis	25.9%
13	Hepatolenticular Degeneration	25.7%
14	Subdural Effusion	25.3%
15	Subacute Combined Degeneration	25%
16	Leigh Disease	25%
17	Dandy-Walker Syndrome	24.4%
18	Leukoencephalitis, Acute Hemorrhagic	24.4%
19	Lewy Body Disease	24.1%
20	Galactosemias	24%
21	Urea Cycle Disorders, Inborn	24%
22	Tyrosinemias	24%
23	Polyradiculoneuropathy	23.8%
24	Polyradiculoneuritis	23.8%
25	Kernicterus	23.5%
26	Pneumocephalus	23.3%
27	MELAS Syndrome	23.1%
28	Ophthalmoplegic Migraine	23%
29	Dementia, Vascular	22.8%
30	Akinetic Mutism	22.7%
31	Anoxic Encephalopathy	22.7%
32	Basal Ganglia Diseases	22.7%
33	Brain Damage, Chronic	22.7%
34	Cerebellar Diseases	22.7%
35	Encephalitis	22.7%
36	Encephalomalacia	22.7%
37	Epilepsy	22.7%
38	Hydrocephalus	22.7%
39	Congenital Hydrocephalus	22.7%
40	Hypothalamic Diseases	22.7%
41	Thalamic Diseases	22.7%
42	Intracranial Hypertension	22.7%
43	Aura	22.7%
44	Leukoencephalopathy	22.7%
45	Neuroaxonal Dystrophies	22.7%
46	Headache Disorders	22.7%
47	Intracranial Hypotension	22.7%
48	Brain Edema	22.7%
49	Brain Hypoxia	22.7%
50	Aqueductal Stenosis	22.7%
51	Parkinsonian Disorders	22.7%
52	Posterior Leukoencephalopathy Syndrome	22.4%
53	Posterior reversible encephalopathy syndrome	22.4%
54	Leukoencephalopathy, Progressive Multifocal	22%
55	Carbamoyl-Phosphate Synthase I Deficiency Disease	21.9%
56	Parkinson Disease	21.7%
57	Ocular Motility Disorders	21.3%
58	Cyclophoria	21.3%
59	Encephalomyelitis, Acute Disseminated	21.3%
60	Amyotrophic Lateral Sclerosis	21.2%
61	Homocystinuria	21.2%
62	Epilepsy, Post-Traumatic	21.1%
63	Basal Ganglia Cerebrovascular Disease	21%
64	Refsum Disease	20.5%
65	Brain Abscess	20.2%
66	Myelitis	20.1%
67	Brain Injuries	20.1%
68	Brain Neoplasms	20%
69	Stiff-Person Syndrome	20%
70	Meige Syndrome	19.9%
71	Cerebral Ventriculitis	19.9%
72	Striatonigral Degeneration	19.8%
73	Myoclonic Epilepsy	19.7%
74	Epilepsy, Temporal Lobe	19.7%
75	Epilepsy, Rolandic	19.7%
76	Benign Rolandic Epilepsy	19.7%
77	Meningitis	19.7%
78	Movement Disorders	19.7%
79	Pachymeningitis	19.7%
80	Spinal Cord Diseases	19.7%
81	Epidural Abscess	19.4%
82	Miller Fisher Syndrome	19.3%
83	Prion Diseases	19%
84	Progressive supranuclear palsy	18.8%
85	Vascular Headaches	18.7%
86	Guillain-Barre Syndrome	18.6%
87	Hypoxia-Ischemia, Brain	18.6%
88	Cerebellar Neoplasms	18.6%
89	Cranial nerve diseases	18.6%
90	Neuromuscular Diseases	18.6%
91	Chronobiology Disorders	18.6%
92	Huntington Disease	18.5%
93	Dystonia Musculorum Deformans	18.5%
94	Friedreich Ataxia	18.5%
95	Glycogen storage disease type II	18.5%
96	Spinal Muscular Atrophy	18.4%
97	Progressive Muscular Atrophy	18.4%
98	Cerebrovascular Disorders	18.4%
99	Cerebrovascular Insufficiency	18.4%
100	Dementia	18.4%
101	Myelitis, Transverse	18.3%
102	Neuromyelitis Optica	18.2%
103	Menkes Kinky Hair Syndrome	18%
104	Leukomalacia, Periventricular	18%
105	Brain Death	18%
106	Neuroleptic Malignant Syndrome	18%
107	Motor Neuron Disease	17.9%
108	Shy-Drager Syndrome	17.3%
109	Gaucher Disease	17.2%
110	Juvenile Myoclonic Epilepsy	17%
111	Myoclonic Epilepsies, Progressive	17%
112	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	17%
113	Fabry Disease	17%
114	Zellweger Syndrome	16.7%
115	Multiple Sclerosis	16.7%
116	Poliomyelitis	16.7%
117	MPTP Poisoning	16.6%
118	Creutzfeldt-Jakob disease	16.6%
119	Wasting Syndrome	16.6%
120	Spinal Cord Injuries	16.4%
121	Lupus Vasculitis, Central Nervous System	16.3%
122	Central Nervous System Infection	16.3%
123	Amblyopia	16.2%
124	Limbic Encephalitis	16.1%
125	Hypercalcemia	16.1%
126	Hypocalcemia	16.1%
127	Milk-Alkali Syndrome	16.1%
128	Cerebral Palsy	15.8%
129	Epilepsies, Partial	15.8%
130	Epilepsy, Generalized	15.8%
131	Pseudotumor Cerebri	15.8%
132	Hypertensive Encephalopathy	15.8%
133	Simple Partial Seizures	15.8%
134	Epilepsy, Reflex	15.8%
135	Headache Disorders, Primary	15.8%
136	Headache Disorders, Secondary	15.8%
137	Medication overuse headache	15.8%
138	Asterixis	15.8%
139	Ballismus	15.8%
140	Restless Legs Syndrome	15.7%
141	Tay-Sachs Disease	15.6%
142	Presenile dementia	15.6%
143	Senile dementia	15.6%
144	Lafora Disease	15.5%
145	Unverricht-Lundborg Syndrome	15.5%
146	Basal Ganglia Hemorrhage	15.5%
147	Acid-Base Imbalance	15.4%
148	Calcium Metabolism Disorders	15.4%
149	Iron Metabolism Disorders	15.4%
150	Phosphorus Metabolism Disorders	15.4%
151	Water-Electrolyte Imbalance	15.4%
152	Lipid Metabolism Disorders	15.4%
153	Mitochondrial Diseases	15.4%
154	Glucose Metabolism Disorders	15.4%
155	Trauma, Nervous System	15.3%
156	Brain Hemorrhage, Traumatic	15%
157	Autonomic Dysreflexia	15%
158	Complex Regional Pain Syndromes	15%
159	Niemann-Pick Disease, Type C	14.9%
160	Nervous System Neoplasms	14.9%
161	Neurologic Manifestations	14.9%
162	Neurotoxicity Syndromes	14.9%
163	Ataxia Telangiectasia	14.7%
164	Pituitary Adenoma	14.5%
165	Pituitary Neoplasms	14.5%
166	Meningitis, Bacterial	14.4%
167	Meningitis, Fungal	14.4%
168	Brain Injuries, Diffuse	14.3%
169	Traumatic Brain Injury	14.3%
170	Cerebellar Ataxia	14.2%
171	Supratentorial Neoplasms	14.2%
172	Carotid Artery Injuries	14.2%
173	Pituitary Apoplexy	14.2%
174	Chronic Fatigue Syndrome	14.1%
175	Brain Infarction	14%
176	Frontotemporal dementia	13.8%
177	Pseudohypoparathyroidism	13.7%
178	Persistent Vegetative State	13.6%
179	Putaminal Hemorrhage	13.6%
180	Amnesia, Transient Global	13.6%
181	Vasculitis, Central Nervous System	13.4%
182	Lipodystrophy	13.4%
183	Opsoclonus-Myoclonus Syndrome	13.4%
184	Spinal Cord Neoplasms	13.3%
185	Paraneoplastic Cerebellar Degeneration	13.3%
186	Infarction, Middle Cerebral Artery	13.2%
187	Infarction, Anterior Cerebral Artery	13.2%
188	Infarction, Posterior Cerebral Artery	13.2%
189	Pituitary Diseases	13.2%
190	Multiple Sclerosis, Chronic Progressive	13.2%
191	Multiple Sclerosis, Relapsing-Remitting	13.2%
192	Amyloid Neuropathies, Familial	13.1%
193	Toxoplasmosis, Cerebral	12.8%
194	Causalgia	12.7%
195	Carotid Artery Diseases	12.7%
196	Brain Ischemia	12.7%
197	Cerebrovascular accident	12.7%
198	Kluver-Bucy Syndrome	12.7%
199	Vasospasm, Intracranial	12.7%
200	Intracranial Arterial Diseases	12.7%
201	Arachnoiditis	12.6%
202	Aseptic Meningitis	12.6%
203	Syringomyelia	12.6%
204	Essential Tremor	12.6%
205	Familial Tremor	12.6%
206	Pneumorrhachis	12.6%
207	Writer's Cramp	12.6%
208	Sleep Wake Disorders	12.6%
209	Peripheral Nerve Injuries	12.6%
210	Rickets	12.5%
211	Post-Traumatic Headache	12.4%
212	Tension Headache	12.4%
213	Epilepsy, Complex Partial	12.4%
214	Migraine Disorders	12.4%
215	Abdominal Migraine	12.4%
216	Status Migrainosus	12.4%
217	Cervicogenic Headache	12.4%
218	Myasthenia Gravis	12.4%
219	Osteopenia	12.4%
220	Dyskinesia, Drug-Induced	12.4%
221	Progressive bulbar palsy	12.1%
222	Bulbar palsy	12.1%
223	Cerebral Infarction	12.1%
224	Brain Stem Infarctions	12.1%
225	Cerebral Amyloid Angiopathy	12%
226	Mitochondrial Myopathies	11.9%
227	Olfactory Nerve Injuries	11.8%
228	Akathisia, Drug-Induced	11.8%
229	Tuberculosis, Meningeal	11.8%
230	Lambert-Eaton Myasthenic Syndrome	11.6%
231	Diffuse Axonal Injury	11.4%
232	Moyamoya Disease	11.4%
233	Brain Stem Neoplasms	11.4%
234	Scrapie	11.2%
235	Central Cord Syndrome	11.2%
236	Dysautonomia	11.1%
237	Vagus Nerve Disorder	11.1%
238	Glossopharyngeal Neuralgia	11.1%
239	Abducens Nerve Diseases	11.1%
240	Heavy Metal Poisoning, Nervous System	11.1%
241	Neuromuscular Junction Diseases	11.1%
242	Tauopathies	11.1%
243	Trochlear Nerve Diseases	11.1%
244	Peripheral Nervous System Diseases	11.1%
245	Lateral Medullary Syndrome	11.1%
246	Chorea	11%
247	Sleep Disorders, Circadian Rhythm	10.9%
248	Hyperhomocysteinemia	10.9%
249	Cluster Headache	10.8%
250	Migraine with Aura	10.8%
251	Familial Hemiplegic Migraine	10.8%
252	Chronic Paroxysmal Hemicrania	10.8%
253	SUNCT Syndrome	10.8%
254	Paroxysmal Hemicrania	10.8%
255	Subarachnoid Hemorrhage, Traumatic	10.7%
256	Carotid Artery, Internal, Dissection	10.7%
257	Reflex Sympathetic Dystrophy	10.7%
258	Nocturnal Myoclonus Syndrome	10.7%
259	Botulism	10.6%
260	Central Nervous System Cysts	10.6%
261	Intracranial Embolism and Thrombosis	10.5%
262	Neuronal Ceroid-Lipofuscinoses	10.5%
263	Hyperlipoproteinemia Type IV	10.5%
264	Hyperlipoproteinemia Type V	10.5%
265	Facial Nerve Injuries	10.4%
266	Subacute Sclerosing Panencephalitis	10.3%
267	Central Nervous System Fungal Infections	10.2%
268	Conus Medullaris Syndrome	10.2%
269	Spinal Cord Vascular Diseases	10.2%
270	Brain Concussion	10.2%
271	Empty Sella Syndrome	10.1%
272	Hyperpituitarism	10.1%
273	Hypopituitarism	10.1%
274	Hypophysitis	10.1%
275	Acidosis	10.1%
276	Alkalosis	10.1%
277	Amyloidosis	10.1%
278	Calcinosis	10.1%
279	Hyperglycemia	10.1%
280	Hyperinsulinism	10.1%
281	Hyperkalemia	10.1%
282	Hypernatremia	10.1%
283	Hypoglycemia	10.1%
284	Hypokalemia	10.1%
285	Hyponatremia	10.1%
286	Xanthomatosis	10.1%
287	Hypophosphatemia	10.1%
288	Metabolic acidosis	10.1%
289	Dyslipidemias	10.1%
290	Iron Overload	10.1%
291	Xanthoma	10.1%
292	Familial Hypophosphatemic Rickets	10.1%
293	Choroid Plexus Papilloma	10%
294	Tetany	9.9%
295	Lactose Intolerance	9.9%
296	Cerebral Arterial Diseases	9.9%
297	Vertebrobasilar Insufficiency	9.9%
298	Basilar Artery Stenosis	9.9%
299	Vertebral Artery Stenosis	9.9%
300	Intracranial Hemorrhage, Hypertensive	9.9%
301	Transient Cerebral Ischemia	9.9%
302	Vertebral Artery Dissection	9.9%
303	Hypolipoproteinemias	9.9%
304	Torticollis	9.9%
305	Smith-Lemli-Opitz Syndrome	9.9%
306	Brain Contusion	9.8%
307	Alice in Wonderland Syndrome	9.8%
308	Horner Syndrome	9.5%
309	Auditory Perceptual Disorders	9.5%
310	Meningitis, Cryptococcal	9.4%
311	Osteomalacia	9.4%
312	Kearns-Sayre syndrome	9.4%
313	Meningitis, Listeria	9.4%
314	Meningitis, Haemophilus	9.3%
315	Meningitis, Pneumococcal	9.3%
316	Brachial Plexus Neuritis	9.3%
317	Neuralgic Amyotrophy	9.3%
318	Myopathy	9.2%
319	Optic Neuropathy	9.2%
320	Myasthenia Gravis, Autoimmune, Experimental	9.2%
321	Diabetic Ketoacidosis	9.1%
322	Hyperlipidemia, Familial Combined	9%
323	Charcot-Marie-Tooth Disease	9%
324	Facial Nerve Diseases	9%
325	Craniocerebral Trauma	9%
326	Parasomnia	9%
327	Dyssomnias	9%
328	Nutrition Disorders	8.8%
329	Vestibulocochlear Nerve Diseases	8.8%
330	Decerebrate State	8.8%
331	Hemiparesis	8.8%
332	Hydranencephaly	8.8%
333	Meningism	8.8%
334	Neural Tube Defects	8.8%
335	Paresis	8.8%
336	Seizures	8.8%
337	Sensation Disorders	8.8%
338	Tethered Cord Syndrome	8.8%
339	Central Nervous System Neoplasms	8.8%
340	Complex partial seizures	8.8%
341	Iniencephaly	8.8%
342	Craniorachischisis	8.8%
343	Exencephaly	8.8%
344	Monoparesis	8.8%
345	Septo-Optic Dysplasia	8.8%
346	Cortical Dysplasia	8.8%
347	Neurogenic Inflammation	8.8%
348	Gait Disorders, Neurologic	8.8%
349	Neuromuscular Manifestations	8.8%
350	Malformations of Cortical Development	8.8%
351	Acrodynia	8.8%
352	Hyperphosphaturia	8.8%
353	Sweating, Gustatory	8.8%
354	Auriculotemporal Syndrome	8.8%
355	Tardive Dyskinesia	8.7%
356	Congenital Hyperinsulinism	8.7%
357	Ophthalmoplegia	8.7%
358	External Ophthalmoplegia	8.7%
359	Hyperprolactinemia	8.6%
360	Hyperlipoproteinemia Type III	8.6%
361	Familial Periodic Paralysis	8.6%
362	Tarsal Tunnel Syndrome	8.6%
363	Cauda Equina Syndrome	8.6%
364	Central Nervous System Bacterial Infections	8.6%
365	Subclavian Steal Syndrome	8.5%
366	Pick Disease of the Brain	8.5%
367	Diabetes Mellitus	8.4%
368	Jet Lag Syndrome	8.4%
369	West Nile Fever	8.3%
370	Carotid Stenosis	8.3%
371	Intracranial Aneurysm	8.3%
372	Intracranial Arteriosclerosis	8.2%
373	Cerebral Atherosclerosis	8.2%
374	Subarachnoid Hemorrhage	8.2%
375	Cerebral Arteriosclerosis	8.2%
376	Cerebral Hemorrhage	8.2%
377	Optic Atrophy, Hereditary, Leber	8.2%
378	Tuberous Sclerosis	8.2%
379	Cerebral Thrombosis	8.2%
380	Intracranial Embolism	8.2%
381	Intracranial Thrombosis	8.2%
382	Hypoalphalipoproteinemias	8.2%
383	Dehydration	8.2%
384	Lipomatosis	8.2%
385	Water Intoxication	8.2%
386	Werner Syndrome	8.2%
387	Achlorhydria	8.1%
388	Amino Acid Metabolism, Inborn Errors	8.1%
389	Bloom Syndrome	8.1%
390	Carbohydrate Metabolism, Inborn Errors	8.1%
391	Metal Metabolism, Inborn Errors	8.1%
392	Osteoporosis	8.1%
393	Progeria	8.1%
394	Lysosomal Storage Diseases	8.1%
395	Bone Demineralization, Pathologic	8.1%
396	Cytochrome-c Oxidase Deficiency	8.1%
397	Peroxisomal Disorders	8.1%
398	Post-Traumatic Osteoporosis	8.1%
399	Coma, Post-Head Injury	8%
400	Celiac Disease	8%
401	Sprue, Tropical	8%
402	Steatorrhea	8%
403	Sprue	8%
404	Demyelinating Diseases	8%
405	Demyelination	8%
406	Giant Cell Arteritis	7.9%
407	Temporal Arteritis	7.9%
408	AIDS Dementia Complex	7.8%
409	Cockayne Syndrome	7.8%
410	Vocal Cord Paralysis	7.6%
411	Myotonia Congenita	7.6%
412	Pupil Disorders	7.6%
413	Neurobehavioral Manifestations	7.6%
414	Neuritis	7.6%
415	Polyneuritis	7.6%
416	Radiculitis	7.6%
417	Polyneuropathy	7.6%
418	Mononeuritis	7.6%
419	Mononeuropathies	7.6%
420	Brachial Plexus Neuropathies	7.6%
421	Radiculopathy	7.6%
422	Mononeuropathy Multiplex	7.6%
423	Nerve Root Compression	7.6%
424	Cerebrospinal Fluid Otorrhea	7.5%
425	Cerebrospinal Fluid Rhinorrhea	7.5%
426	Neuritis, Autoimmune, Experimental	7.5%
427	Gait Ataxia	7.5%
428	Acidosis, Lactic	7.5%
429	Calciphylaxis	7.5%
430	Hemosiderosis	7.5%
431	Ketosis	7.5%
432	Ketonuria	7.5%
433	Ketoacidosis	7.5%
434	Ketonemia	7.5%
435	Vascular calcification	7.5%
436	Paraneoplastic Encephalomyelitis	7.4%
437	Renal tubular acidosis	7.4%
438	Uveomeningoencephalitic Syndrome	7.3%
439	Spinal Cord Ischemia	7.3%
440	Sturge-Weber Syndrome	7.3%
441	Vertigo	7.3%
442	Alcohol-Induced Disorders, Nervous System	7.3%
443	Myotonic Dystrophy	7.3%
444	Tuberculosis, Central Nervous System	7.2%
445	Hematoma, Subdural	7.2%
446	Hematoma, Epidural, Cranial	7.2%
447	Acromegaly	7.2%
448	Carpal Tunnel Syndrome	7.2%
449	neurofibroma	7.1%
450	Sciatica	7.1%
451	Nesidioblastosis	7.1%
452	Sinus Thrombosis, Intracranial	7.1%
453	Carotid Artery Thrombosis	7%
454	Brain Diseases	6.8%
455	Hypokalemic periodic paralysis	6.8%
456	Optic Nerve Glioma	6.7%
457	Glycosuria	6.7%
458	HIV Wasting Syndrome	6.6%
459	Alcohol Withdrawal Seizures	6.6%
460	Akathisia	6.6%
461	Restlessness	6.6%
462	Psychomotor Agitation	6.6%
463	Renal Osteodystrophy	6.6%
464	Renal rickets	6.6%
465	Cubital Tunnel Syndrome	6.6%
466	HIV-Associated Lipodystrophy Syndrome	6.6%
467	Cavernous Sinus Thrombosis	6.5%
468	Sagittal Sinus Thrombosis	6.5%
469	Hematoma, Subdural, Intracranial	6.5%
470	Hematoma, Subdural, Chronic	6.5%
471	Hematoma, Subdural, Acute	6.5%
472	Voice Disorders	6.4%
473	Voice Disturbance	6.4%
474	Smith-Magenis syndrome	6.3%
475	Dural Arteriovenous Fistula	6.2%
476	Hypercholesterolemia	6.2%
477	Hyperlipoproteinemias	6.2%
478	Hypertriglyceridemia	6.2%
479	Mucopolysaccharidosis II	6.2%
480	Gait Apraxia	6.1%
481	Myositis	6.1%
482	Optic Atrophy	6.1%
483	Optic Neuritis	6.1%
484	Papilledema	6.1%
485	Strabismus	6.1%
486	Tolosa-Hunt Syndrome	6.1%
487	Isaacs syndrome	6.1%
488	Arsenic Poisoning	6.1%
489	Myotonic Disorders	6.1%
490	Myasthenic Syndromes, Congenital	6.1%
491	Neuroaspergillosis	6.1%
492	Mucopolysaccharidosis III	6.1%
493	Diabetic Neuropathies	6%
494	Facial Injuries	6%
495	Facial Neuralgia	6%
496	Diabetic Amyotrophy	6%
497	Diabetic Autonomic Neuropathy	6%
498	Sleep Talking	6%
499	Manganese Poisoning	6%
500	Sleep Disorders, Intrinsic	6%
501	Orthostatic intolerance	6%
502	Alstrom Syndrome	6%
503	Acidosis, Respiratory	6%
504	Adiposis Dolorosa	6%
505	Alkalosis, Respiratory	6%
506	Anosmia	6%
507	Ataxia	6%
508	Athetosis	6%
509	Catalepsy	6%
510	Dystonia	6%
511	Hemiplegia	6%
512	Locked-In Syndrome	6%
513	Meningeal Neoplasms	6%
514	Meningomyelocele	6%
515	Muscle Hypertonia	6%
516	Muscle hypotonia	6%
517	Myoclonus	6%
518	Myotonia	6%
519	Neuralgia	6%
520	Paraplegia	6%
521	Pseudobulbar Palsy	6%
522	Quadriplegia	6%
523	Spasm	6%
524	Spastic Paraplegia	6%
525	Status Epilepticus	6%
526	Taste Disorders	6%
527	Tremor	6%
528	Spina Bifida	6%
529	Monoplegia	6%
530	Hypokinesia	6%
531	Paraparesis	6%
532	Bradykinesia	6%
533	Waxy flexibility	6%
534	Action Tremor	6%
535	Resting Tremor	6%
536	Dysosmia	6%
537	Quadriparesis	6%
538	Mercury Poisoning, Nervous System	6%
539	Olfaction Disorders	6%
540	Myokymia	6%
541	Lead Poisoning, Nervous System	6%
542	Vestibular Neuronitis	6%
543	Somatosensory Disorders	6%
544	Neuropathic pain	6%
545	Hyperkinesia	6%
546	Intention tremor	6%
547	Alkaptonuria	6%
548	Glycogen Storage Disease	6%
549	Hypophosphatasia	6%
550	Insulin Resistance	6%
551	Osteoporosis, Postmenopausal	6%
552	Propionic acidemia	6%
553	Dihydropyrimidine Dehydrogenase Deficiency	6%
554	Cystinosis	6%
555	Anterior Spinal Artery Syndrome	5.9%
556	Glycosuria, Renal	5.9%
557	Sciatic Neuropathy	5.8%
558	Ulnar Neuropathies	5.8%
559	Lesion of Sciatic Nerve	5.8%
560	Ulnar Neuritis	5.8%
561	Radial nerve compression	5.8%
562	Radial Tunnel Syndrome	5.8%
563	Peroneal Neuropathies	5.8%
564	Radial Neuropathy	5.8%
565	Median Neuropathy	5.8%
566	Sciatic Nerve Palsy	5.8%
567	Femoral Neuropathy	5.8%
568	Tibial Neuropathy	5.8%
569	Ulnar Nerve Palsy	5.8%
570	Postural Orthostatic Tachycardia Syndrome	5.8%
571	Radial nerve palsy	5.8%
572	Porphyrias, Hepatic	5.8%
573	Necrobiosis Lipoidica Diabeticorum	5.7%
574	Fanconi Anemia	5.7%
575	Myelinolysis, Central Pontine	5.6%
576	Nelson Syndrome	5.6%
577	Pseudorabies	5.4%
578	Reflex, Abnormal	5.4%
579	Hyporeflexia	5.4%
580	Hyperreflexia	5.4%
581	Prolactinoma	5.4%
582	Growth Hormone-Secreting Pituitary Adenoma	5.4%
583	Classical Lissencephalies and Subcortical Band Heterotopias	5.3%
584	Hand-Arm Vibration Syndrome	5.3%
585	Vision Disorders	5.2%
586	Metamorphopsia	5.2%
587	Visual Impairment	5.2%
588	Neurosyphilis	5.2%
589	Fibromyalgia	5.1%
590	Optic Neuropathy, Ischemic	5.1%
591	Anterior Ischemic Optic Neuropathy	5.1%
592	Medial Tibial Stress Syndrome	5.1%
593	Child Nutrition Disorders	5.1%
594	Hypervitaminosis A	5.1%
595	Infant Nutrition Disorders	5.1%
596	Malnutrition	5.1%
597	Gestational Diabetes	5.1%
598	Latent Autoimmune Diabetes in Adults	5.1%
599	Facial Hemiatrophy	5.1%
600	Melkersson-Rosenthal Syndrome	5.1%
601	Anisocoria	5.1%
602	Confusion	5.1%
603	Diabetes Mellitus, Experimental	5.1%
604	Facial paralysis	5.1%
605	Lethargy	5.1%
606	Memory Disorders	5.1%
607	Muscle Cramp	5.1%
608	Perceptual Disorders	5.1%
609	Psychomotor Disorders	5.1%
610	Tonic Pupil	5.1%
611	Eosinophilia-Myalgia Syndrome	5.1%
612	Anhedonia	5.1%
613	Disorientation	5.1%
614	Facial Paresis	5.1%
615	Memory Loss	5.1%
616	Hemisensory Neglect	5.1%
617	Dysacusis	5.1%
618	Sleep Bruxism	5%
619	Toxoplasmosis, Congenital	5%
620	Anencephaly	5%
621	Meningocele	5%
622	Muscular Atrophy	5%
623	Respiratory Paralysis	5%
624	Encephalocele	5%
625	Malaria, Cerebral	5%
626	Polyradiculopathy	5%
627	Nephrocalcinosis	5%
628	Neurocysticercosis	4.9%
629	Glycogen Storage Disease Type I	4.9%
630	Glycogen Storage Disease Type V	4.9%
631	Acoustic Neuroma	4.9%
632	Alexia	4.9%
633	Dyslexia	4.9%
634	Thoracic Outlet Syndrome	4.7%
635	Esotropia	4.7%
636	Exotropia	4.7%
637	Hypotension, Orthostatic	4.7%
638	Sleep Apnea Syndromes	4.7%
639	Polymyositis	4.7%
640	Post-Exercise Hypotension	4.7%
641	Neurofibrosarcoma	4.7%
642	Disorders of Excessive Somnolence	4.6%
643	Sleep Initiation and Maintenance Disorders	4.6%
644	Night Terrors	4.6%
645	Somnambulism	4.6%
646	Trigeminal Nerve Disorder	4.6%
647	Transient Insomnia	4.6%
648	Sleep Paralysis	4.6%
649	Chronic Insomnia	4.6%
650	REM Sleep Behavior Disorder	4.6%
651	Hypersomnia	4.6%
652	Dermal Sinus	4.6%
653	Dysgeusia	4.6%
654	Formication	4.6%
655	Hyperalgesia	4.6%
656	Hyperesthesia	4.6%
657	Hypesthesia	4.6%
658	Language Disorders	4.6%
659	Numbness	4.6%
660	Paresthesia	4.6%
661	Paraparesis, Spastic	4.6%
662	Spina Bifida Cystica	4.6%
663	Trismus	4.6%
664	Spina Bifida Occulta	4.6%
665	Epilepsia Partialis Continua	4.6%
666	Hypogeusia	4.6%
667	Meningeal Carcinomatosis	4.6%
668	Brown-Sequard Syndrome	4.6%
669	Lissencephaly	4.6%
670	Polymicrogyria	4.6%
671	Pachygyria	4.6%
672	Schizencephaly	4.6%
673	Lockjaw	4.6%
674	Allodynia	4.6%
675	Lead Poisoning, Nervous System, Childhood	4.6%
676	Lead Poisoning, Nervous System, Adult	4.6%
677	Periventricular Nodular Heterotopia	4.6%
678	Ageusia	4.6%
679	Waterhouse-Friderichsen Syndrome	4.6%
680	Sjogren-Larsson Syndrome	4.5%
681	Lyme Neuroborreliosis	4.5%
682	Duane Retraction Syndrome	4.4%
683	Consciousness Disorders	4.4%
684	Mental Retardation	4.4%
685	Muscle Weakness	4.4%
686	Depressed Level of Consciousness	4.4%
687	Mental deficiency	4.4%
688	Intellectual Disability	4.4%
689	Mobius Syndrome	4.3%
690	Bell Palsy	4.3%
691	Catatonia	4.3%
692	Herpes Zoster Oticus	4.3%
693	Aphonia	4.3%
694	Sleep Deprivation	4.3%
695	Primary amyloidosis	4.3%
696	Dysphonia	4.3%
697	Variegate Porphyria	4.2%
698	Acute intermittent porphyria	4.2%
699	Porphyria Cutanea Tarda	4.2%
700	Renal Aminoacidurias	4.2%
701	Fanconi Syndrome	4.2%
702	Pseudohypoaldosteronism	4.2%
703	Liddle Syndrome	4.2%
704	Prader-Willi Syndrome	4.1%
705	Brain Diseases, Metabolic	4.1%
706	Eye Injuries	4%
707	Sleep Apnea, Obstructive	4%
708	Sleep Apnea, Central	4%
709	Narcolepsy	3.9%
710	Trigeminal Neuralgia	3.9%
711	Kleine-Levin Syndrome	3.9%
712	Agraphia	3.9%
713	Anomia	3.9%
714	Cluttering	3.9%
715	Language Development Disorders	3.9%
716	Speech Disorders	3.9%
717	Syncope	3.9%
718	Stupor	3.9%
719	Dysgraphia	3.9%
720	Presyncope	3.9%
721	Dyslalia	3.9%
722	Muscular Dystrophy	3.9%
723	Congenital nystagmus	3.9%
724	Orbital Myositis	3.9%
725	Diplopia	3.9%
726	Muscle Rigidity	3.9%
727	Muscle Spasticity	3.9%
728	Scotoma	3.9%
729	Photophobia	3.9%
730	Cogwheel Rigidity	3.9%
731	Hemifacial Spasm	3.9%
732	Amaurosis	3.9%
733	Blindness	3.9%
734	Nuchal Rigidity	3.9%
735	Pyomyositis	3.9%
736	Agnosia	3.9%
737	Apraxias	3.9%
738	Hallucinations	3.9%
739	Hemianopsia	3.9%
740	Hyperacusis	3.9%
741	Tinnitus	3.9%
742	Visual Agnosia	3.9%
743	Anosognosia	3.9%
744	Wernicke-Korsakoff Syndrome	3.9%
745	Phonophobia	3.9%
746	Hearing Loss	3.9%
747	Sarcopenia	3.8%
748	Gout	3.8%
749	Myalgia	3.7%
750	Antley-Bixler Syndrome Phenotype	3.7%
751	Xeroderma Pigmentosum	3.7%
752	Cataplexy	3.6%
753	Aphasia	3.6%
754	Articulation Disorders	3.6%
755	Echolalia	3.6%
756	Stuttering	3.6%
757	Dysphasia	3.6%
758	Cystinuria	3.5%
759	Dysarthria	3.4%
760	Aicardi's syndrome	3.4%
761	Deficiency Diseases	3.4%
762	Starvation	3.4%
763	Refeeding Syndrome	3.4%
764	Hoarseness	3.4%
765	Amnesia	3.3%
766	Delirium	3.3%
767	Dissociative Amnesia	3.3%
768	Color blindness	3.3%
769	Global Amnesia	3.3%
770	Cri-du-Chat Syndrome	3.3%
771	Down Syndrome	3.3%
772	Eye Burns	3.3%
773	Trisomy 21	3.3%
774	POEMS Syndrome	3.3%
775	Alcohol Withdrawal Delirium	3.3%
776	Meningioma	3.3%
777	Williams Syndrome	3.3%
778	Welander Distal Myopathy	3.3%
779	Microcephaly	3.3%
780	Macrocephaly	3.3%
781	Amaurosis Fugax	3.3%
782	Blindness, Cortical	3.3%
783	Dyscalculia	3.3%
784	Rett Syndrome	3.3%
785	CREST Syndrome	3.3%
786	Deafness	3.3%
787	Hearing Loss, Sudden	3.3%
788	Gerstmann Syndrome	3.3%
789	Hearing Loss, Bilateral	3.3%
790	Hearing Loss, High-Frequency	3.3%
791	Hearing Loss, Mixed Conductive-Sensorineural	3.3%
792	Prosopagnosia	3.3%
793	Apraxia, Ideomotor	3.3%
794	Charles Bonnet Syndrome	3.3%
795	Hearing Loss, Unilateral	3.3%
796	Complete Hearing Loss	3.3%
797	Alien Hand Syndrome	3.3%
798	Deaf Mutism	3.3%
799	Porencephaly	3.3%
800	Arthritis, Gouty	3.1%
801	Mutism	3%
802	Selective Mutism	3%
803	Albinism	3%
804	Holoprosencephaly	3%
805	Dermatomyositis	2.9%
806	Corneal Scar	2.9%
807	Alexia, Pure	2.9%
808	Phantom pain	2.9%
809	Phantom Limb Pain	2.9%
810	Muscular Dystrophy, Duchenne	2.8%
811	Retrograde amnesia	2.8%
812	Amnesia, Anterograde	2.8%
813	Corneal Perforation	2.6%
814	Kwashiorkor	2.5%
815	Magnesium Deficiency	2.5%
816	Potassium Deficiency	2.5%
817	Protein Deficiency	2.5%
818	Avitaminosis	2.5%
819	Ichthyosis, X-Linked	2.5%
820	Fragile X Syndrome	2.5%
821	Rubinstein-Taybi Syndrome	2.3%
822	Ascorbic Acid Deficiency	2.1%
823	Vitamin A Deficiency	2.1%
824	Vitamin D Deficiency	2.1%
825	Vitamin E Deficiency	2.1%
826	Marasmus	2.1%
827	Obesity	1.9%
828	Folic Acid Deficiency	1.9%
829	Pellagra	1.9%
830	Thiamine Deficiency	1.9%
831	Vitamin B 12 Deficiency	1.9%
832	Vitamin B 6 Deficiency	1.9%
833	Pyridoxine Deficiency	1.9%
834	Beriberi	1.8%
835	Obesity, Abdominal	1.6%
836	Anemia, Pernicious	1.4%
837	Pediatric Obesity	1.4%
838	Vitamin K Deficiency	1.4%
839	Scurvy	1.2%

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