MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Multiple Epiphyseal Dysplasia

(UMLS:C0026760)

UMLS ID:: C0026760
MeSH ID:: D010009

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.708

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.728

Synonym(s)

Multiple Epiphyseal Dysplasia

Fairbanks-Ribbing type epiphyseal dysplasia

MED - Multiple epiphyseal dysplasia

Multiple epiphyseal dysplasia

Multiple epiphyseal dysplasia syndrome

multiple epiphyseal dysplasia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Topiramate	FAERS: 1		US FAERS
2	reviparin	FAERS: 1		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Dwarfism	37.1%
2	Dysostoses	31.8%
3	Pectus excavatum	27.4%
4	Platybasia	27.4%
5	Gigantism	27%
6	Cockayne Syndrome	26.4%
7	Congenital Hypothyroidism	24.6%
8	Marfan Syndrome	23.8%
9	Fragile X Syndrome	23.4%
10	Pectus carinatum	22.5%
11	Klippel-Feil Syndrome	22.4%
12	Synostosis	22.4%
13	Rubinstein-Taybi Syndrome	22.1%
14	Neoplastic Syndromes, Hereditary	21.8%
15	Muscular Dystrophy, Duchenne	21.6%
16	Osteoarthropathy, Secondary Hypertrophic	21.1%
17	Hyperostosis	20.9%
18	Osteitis	20.9%
19	Osteitis Deformans	20.9%
20	Osteochondrosis	20.9%
21	Spinal Diseases	20.9%
22	Aicardi's syndrome	20.9%
23	Nail-Patella Syndrome	20.7%
24	Pelger-Huet Anomaly	20.7%
25	Werner Syndrome	20.7%
26	Myasthenic Syndromes, Congenital	20.7%
27	CHARGE Syndrome	20.5%
28	Familial Mediterranean Fever	20.5%
29	Beckwith-Wiedemann Syndrome	20.3%
30	Wolf-Hirschhorn Syndrome	20.3%
31	Anemia, Sickle Cell	20.1%
32	Thalassemia	20.1%
33	Craniofacial Dysostosis	20%
34	Rett Syndrome	19.8%
35	Antley-Bixler Syndrome Phenotype	19.5%
36	Muscular Dystrophy	19%
37	Albinism	19%
38	Cystic Fibrosis	18.8%
39	Ichthyosis, X-Linked	18.6%
40	Mucopolysaccharidosis II	18.5%
41	Alstrom Syndrome	17.3%
42	Smith-Magenis syndrome	17%
43	Craniosynostosis	16.8%
44	Syndactyly	16.8%
45	Brachycephaly	16.8%
46	Cri-du-Chat Syndrome	16.8%
47	Down Syndrome	16.8%
48	Trisomy 21	16.8%
49	Osteochondritis	16.7%
50	Acrocephalosyndactylia	16.6%
51	Basal Cell Nevus Syndrome	16.5%
52	Sickle Cell Trait	16.4%
53	Bone Diseases, Endocrine	16.4%
54	Osteogenesis Imperfecta	16.3%
55	Menkes Kinky Hair Syndrome	16.3%
56	Holoprosencephaly	16.3%
57	Spinal Neoplasms	16.2%
58	Spondylitis	16.2%
59	Myotonic Dystrophy	15.8%
60	Bone Diseases, Infectious	15.8%
61	Bone neoplasms	15.8%
62	Osteopenia	15.8%
63	Bone Resorption	15.5%
64	Aseptic Necrosis of Bone	15.5%
65	Amino Acid Metabolism, Inborn Errors	15.3%
66	Carbohydrate Metabolism, Inborn Errors	15.3%
67	Metal Metabolism, Inborn Errors	15.3%
68	Progeria	15.3%
69	Lysosomal Storage Diseases	15.3%
70	Cytochrome-c Oxidase Deficiency	15.3%
71	Peroxisomal Disorders	15.3%
72	Wiskott-Aldrich Syndrome	15%
73	Neuronal Ceroid-Lipofuscinoses	14.9%
74	Smith-Lemli-Opitz Syndrome	14.8%
75	Goldenhar Syndrome	14.7%
76	Deformity	14.6%
77	Ectodermal Dysplasia	14.4%
78	Aplasia Cutis Congenita	14.4%
79	Poland Syndrome	14.3%
80	Prader-Willi Syndrome	14.3%
81	Kartagener Syndrome	14.1%
82	Arthrogryposis	14%
83	Welander Distal Myopathy	14%
84	Gout	13.9%
85	Autoimmune Lymphoproliferative Syndrome	13.8%
86	Primary Ciliary Dyskinesia	13.8%
87	Mandibulofacial Dysostosis	13.7%
88	Ainhum	13.6%
89	Spinal Stenosis	13.6%
90	Spondylosis	13.6%
91	Intervertebral Disc Degeneration	13.6%
92	Angioedemas, Hereditary	13.4%
93	Polycystic Kidney Diseases	13.3%
94	Williams Syndrome	13.3%
95	Adrenoleukodystrophy	13.2%
96	Glycogen storage disease type II	13.1%
97	Fabry Disease	12.9%
98	Pseudohypoparathyroidism	12.9%
99	Sjogren-Larsson Syndrome	12.7%
100	Acute Chest Syndrome	12.6%
101	Mucopolysaccharidosis III	12.6%
102	Tuberous Sclerosis	12.6%
103	Refsum Disease	12.5%
104	Alkaptonuria	12.5%
105	Glycogen Storage Disease	12.5%
106	Hypophosphatasia	12.5%
107	Propionic acidemia	12.5%
108	Dihydropyrimidine Dehydrogenase Deficiency	12.5%
109	Cystinosis	12.5%
110	Cutis Laxa	12.3%
111	Myotonia Congenita	12.3%
112	Galactosemias	12.3%
113	Urea Cycle Disorders, Inborn	12.3%
114	Tyrosinemias	12.3%
115	Retinitis Pigmentosa	12.2%
116	Pigmentary retinopathy	12.2%
117	Hepatolenticular Degeneration	12.2%
118	Fasciitis	12.2%
119	Foot Deformities	12.2%
120	Arthropathy	12.2%
121	Porokeratosis	12.2%
122	Keratoderma, Palmoplantar	12.2%
123	Chronic granulomatous disease	12.1%
124	Amyloid Neuropathies, Familial	12%
125	Discitis	11.9%
126	Retinal Dysplasia	11.9%
127	Kallmann Syndrome	11.8%
128	Familial Periodic Paralysis	11.8%
129	Aniridia	11.8%
130	Epidermolysis Bullosa	11.5%
131	Glycogen Storage Disease Type I	11.2%
132	Glycogen Storage Disease Type V	11.2%
133	Gaucher Disease	11.1%
134	Classical Lissencephalies and Subcortical Band Heterotopias	11.1%
135	Arthritis, Gouty	11%
136	Optic Atrophy, Hereditary, Leber	11%
137	Polycystic Kidney, Autosomal Dominant	10.9%
138	Fetal Diseases	10.9%
139	Hyperphosphaturia	10.9%
140	Tay-Sachs Disease	10.6%
141	Contracture	10.5%
142	Fasciitis, Plantar	10.5%
143	Homocystinuria	10.4%
144	Duane Retraction Syndrome	10.3%
145	Leigh Disease	10.3%
146	Limb Deformities, Congenital	10.3%
147	Craniofacial Abnormalities	10.3%
148	Canavan Disease	10.3%
149	Alexander Disease	10.3%
150	Porphyrias, Hepatic	10.2%
151	Osteomyelitis	10.2%
152	Osteoporosis	10.2%
153	Periostitis	10.2%
154	Bone Demineralization, Pathologic	10.2%
155	Post-Traumatic Osteoporosis	10.2%
156	Lordosis	10.1%
157	Spondylolysis	10.1%
158	kyphosis	10.1%
159	Alveolar Bone Loss	10.1%
160	Femur Head Necrosis	10.1%
161	Osteolysis	10.1%
162	Peutz-Jeghers Syndrome	10.1%
163	Thrombasthenia	10.1%
164	Antithrombin III Deficiency	10.1%
165	Protein C Deficiency	10.1%
166	Brain Diseases, Metabolic, Inborn	10.1%
167	Afibrinogenemia	10%
168	Dystonia Musculorum Deformans	10%
169	Factor VII Deficiency	10%
170	Factor X Deficiency	10%
171	Factor XII Deficiency	10%
172	Hemophilia A	10%
173	Activated Protein C Resistance	10%
174	Factor II deficiency	10%
175	Factor VIII Deficiency	10%
176	Factor V deficiency	10%
177	Factor XI Deficiency	10%
178	Hypoprothrombinemias	10%
179	Hyperkeratosis, Epidermolytic	10%
180	Fanconi Anemia	9.9%
181	Hypolipoproteinemias	9.9%
182	Papillon-Lefevre Disease	9.9%
183	Zellweger Syndrome	9.9%
184	Lafora Disease	9.9%
185	Unverricht-Lundborg Syndrome	9.9%
186	Hyperlipidemia, Familial Combined	9.9%
187	Anemia, Diamond-Blackfan	9.9%
188	Hyperlipoproteinemia Type III	9.9%
189	Niemann-Pick Disease, Type C	9.9%
190	Tuberculosis, Spinal	9.8%
191	Carbamoyl-Phosphate Synthase I Deficiency Disease	9.7%
192	Osteoarthritis, Spine	9.6%
193	Hypokalemic periodic paralysis	9.6%
194	Jaw Diseases	9.4%
195	Charcot-Marie-Tooth Disease	9.4%
196	Abdominal Cramps	9.3%
197	Abnormalities, Drug-Induced	9.3%
198	Amniotic Band Syndrome	9.3%
199	Asphyxia Neonatorum	9.3%
200	Infant, Premature, Diseases	9.3%
201	Situs Inversus	9.3%
202	Infantile Colic	9.3%
203	Cartilage Diseases	9.1%
204	Foot Diseases	9.1%
205	Myopathy	9.1%
206	Rheumatism	9.1%
207	Chondromalacia	9.1%
208	Ataxia Telangiectasia	9%
209	Pseudoxanthoma Elasticum	9%
210	Multiple Endocrine Neoplasia	8.9%
211	Hypoalphalipoproteinemias	8.9%
212	Ankylosing spondylitis	8.8%
213	Spondylarthropathies	8.7%
214	Dermatitis, Atopic	8.7%
215	Eosinophilic Granuloma	8.6%
216	Maxillofacial Abnormalities	8.5%
217	Spondylolisthesis	8.4%
218	Fibromyalgia	8.3%
219	Polymyalgia Rheumatica	8.3%
220	Lactose Intolerance	8.3%
221	Variegate Porphyria	8.3%
222	Acute intermittent porphyria	8.3%
223	Porphyria Cutanea Tarda	8.3%
224	Metatarsalgia	8.3%
225	Hyperhomocysteinemia	8.3%
226	Renal Aminoacidurias	8.2%
227	Fanconi Syndrome	8.2%
228	Pseudohypoaldosteronism	8.2%
229	Liddle Syndrome	8.2%
230	Hyperlipoproteinemia Type IV	8.2%
231	Hyperlipoproteinemia Type V	8.2%
232	Gastroschisis	8.2%
233	Klinefelter Syndrome	8.2%
234	Talipes	8.1%
235	Xeroderma Pigmentosum	8.1%
236	Acromegaly	8%
237	Joint Tuberculosis	8%
238	Tuberculosis, Osteoarticular	8%
239	Bone Tuberculosis	8%
240	Xeroderma	8%
241	Mobius Syndrome	8%
242	Meconium Aspiration Syndrome	7.9%
243	Familial Hypophosphatemic Rickets	7.9%
244	Jaw Abnormalities	7.8%
245	Amelia	7.6%
246	Arachnodactyly	7.6%
247	Ectromelia	7.6%
248	Hemimelia	7.6%
249	Phocomelia	7.6%
250	Sirenomelia	7.6%
251	Polydactyly	7.6%
252	Brachydactyly	7.6%
253	Plagiocephaly	7.6%
254	Lower Extremity Deformities, Congenital	7.6%
255	Upper Extremity Deformities, Congenital	7.6%
256	Behcet Syndrome	7.5%
257	Osteoporosis, Postmenopausal	7.5%
258	Microcephaly	7.4%
259	Macrocephaly	7.4%
260	Anencephaly	7.4%
261	Cystinuria	7.3%
262	Eye Abnormalities	7.3%
263	Cardiovascular Abnormalities	7.3%
264	Arthritis, Psoriatic	7.3%
265	Hydrops Fetalis	7.2%
266	Multiple Endocrine Neoplasia Type 1	7.1%
267	Friedreich Ataxia	7.1%
268	Renal tubular acidosis	7%
269	Skin Abnormalities	7%
270	Lymphatic Abnormalities	7%
271	Congenital Microtia	7%
272	Arthritis	7%
273	Bursitis	7%
274	Joint Instability	7%
275	Myofascial Pain Syndromes	7%
276	Rhabdomyolysis	7%
277	Synovitis	7%
278	Joint laxity	7%
279	Polyarthritis	7%
280	Frozen shoulder	7%
281	Patellofemoral Pain Syndrome	7%
282	Turner Syndrome	6.9%
283	Anemia, Neonatal	6.9%
284	Persistent Fetal Circulation Syndrome	6.9%
285	Congenital diaphragmatic hernia	6.8%
286	Prune Belly Syndrome	6.8%
287	Twins, Conjoined	6.8%
288	Waardenburg Syndrome	6.8%
289	Umbilical hernia	6.8%
290	Rheumatic Fever	6.8%
291	Hip Contracture	6.8%
292	Periarthritis	6.8%
293	Ischemic contracture	6.7%
294	Congenital clubfoot	6.7%
295	Vertical Talus	6.7%
296	Arthritis, Reactive	6.7%
297	Rickets	6.7%
298	Huntington Disease	6.6%
299	Porencephaly	6.6%
300	Temporomandibular Joint Disorders	6.4%
301	Prognathism	6.3%
302	Micrognathism	6.3%
303	Pierre Robin Syndrome	6.3%
304	Dural Arteriovenous Fistula	6.2%
305	Dextrocardia	6.1%
306	Cleft Palate	6%
307	Mastoiditis	6%
308	Petrositis	6%
309	Nephroblastoma	6%
310	Laryngomalacia	5.9%
311	Noonan Syndrome	5.9%
312	Osteoarthritis, Knee	5.9%
313	Urogenital Abnormalities	5.8%
314	Rheumatoid Arthritis	5.7%
315	Juvenile arthritis	5.7%
316	Neonatal Abstinence Syndrome	5.6%
317	Temporomandibular Joint Dysfunction Syndrome	5.6%
318	Retrognathia	5.6%
319	Fetal Growth Retardation	5.5%
320	Fetal Hypoxia	5.4%
321	Congenital nystagmus	5.4%
322	Fetal Alcohol Spectrum Disorders	5.4%
323	Glycosuria, Renal	5.4%
324	Toxoplasmosis, Congenital	5.4%
325	Syphilis, Congenital	5.4%
326	Adenomatous Polyposis Coli	5.4%
327	MELAS Syndrome	5.3%
328	Compartment syndromes	5.3%
329	Maxillary Diseases	5.3%
330	Tendinitis	5.3%
331	Tendinopathy	5.3%
332	Anophthalmos	5.2%
333	Anus, Imperforate	5.2%
334	Hemarthrosis	5.2%
335	Hydranencephaly	5.2%
336	Microphthalmos	5.2%
337	Myositis	5.2%
338	Neural Tube Defects	5.2%
339	Paralysis, Obstetric	5.2%
340	Retinopathy of Prematurity	5.2%
341	Tietze's Syndrome	5.2%
342	Tethered Cord Syndrome	5.2%
343	Iniencephaly	5.2%
344	Craniorachischisis	5.2%
345	Isaacs syndrome	5.2%
346	Exencephaly	5.2%
347	Septo-Optic Dysplasia	5.2%
348	Cortical Dysplasia	5.2%
349	Myotonic Disorders	5.2%
350	Malformations of Cortical Development	5.2%
351	Anorectal Malformations	5.2%
352	Bloom Syndrome	5.1%
353	Bronchopulmonary Dysplasia	5%
354	Bronchomalacia	5%
355	Tracheomalacia	5%
356	Osteomalacia	4.9%
357	Palatal Neoplasms	4.8%
358	Scimitar Syndrome	4.7%
359	Rheumatoid Nodule	4.7%
360	Bunion	4.5%
361	Fibrodysplasia Ossificans Progressiva	4.5%
362	Myoglobinuria	4.5%
363	Myositis Ossificans	4.5%
364	Tenosynovitis	4.5%
365	Sacroiliitis	4.5%
366	Congenital Hyperinsulinism	4.5%
367	Chorioamnionitis	4.5%
368	Denys-Drash Syndrome	4.5%
369	Ectopia Cordis	4.2%
370	Meningomyelocele	4.2%
371	Spina Bifida	4.2%
372	Single umbilical artery	4.2%
373	Blepharophimosis	4.2%
374	Laryngostenosis	4.2%
375	Mouth Abnormalities	4.2%
376	Respiratory Distress Syndrome, Newborn	4.2%
377	Medial Tibial Stress Syndrome	4.2%
378	Esophageal Atresia	4.1%
379	Intestinal Atresia	4.1%
380	Mitochondrial Myopathies	4.1%
381	Horseshoe Kidney	4.1%
382	Muscle Cramp	4.1%
383	Eosinophilia-Myalgia Syndrome	4.1%
384	Acrodermatitis	4.1%
385	Lymphangiectasis, Intestinal	4.1%
386	Gianotti-Crosti Syndrome	4.1%
387	Muscle Rigidity	4%
388	Muscle Spasticity	4%
389	Cogwheel Rigidity	4%
390	Nuchal Rigidity	4%
391	Felty Syndrome	3.9%
392	Abnormalities, Radiation-Induced	3.8%
393	Dermal Sinus	3.7%
394	Spina Bifida Cystica	3.7%
395	Spina Bifida Occulta	3.7%
396	Lissencephaly	3.7%
397	Polymicrogyria	3.7%
398	Pachygyria	3.7%
399	Schizencephaly	3.7%
400	Periventricular Nodular Heterotopia	3.7%
401	Chronic Fatigue Syndrome	3.6%
402	Choanal Atresia	3.5%
403	Tracheobronchomegaly	3.5%
404	Laryngocele	3.5%
405	Arthritis, Infectious	3.4%
406	Choledochal Cyst	3.4%
407	Hermaphroditism	3.4%
408	Disorders of Sex Development	3.4%
409	Giant Cell Epulis	3.4%
410	Muscle Weakness	3.4%
411	Nose Neoplasms	3.4%
412	Cryptorchidism	3.4%
413	Hypospadias	3.4%
414	Anterior Compartment Syndrome	3.4%
415	Musculoskeletal Pain	3.4%
416	Enthesopathy	3.4%
417	Central Nervous System Cysts	3.4%
418	Arthritis, Experimental	3.4%
419	Abdominal Compartment Syndrome	3.4%
420	Dandy-Walker Syndrome	3.4%
421	Polymyositis	3.4%
422	Aortic coarctation	3.4%
423	Cor Triatriatum	3.4%
424	Coronary Vessel Anomalies	3.4%
425	Dental Enamel Hypoplasia	3.4%
426	Patent ductus arteriosus	3.4%
427	Ebstein Anomaly	3.4%
428	Heart Septal Defects	3.4%
429	Hyaline Membrane Disease	3.4%
430	Hypodontia	3.4%
431	Macrostomia	3.4%
432	Meningocele	3.4%
433	Microstomia	3.4%
434	Tetralogy of Fallot	3.4%
435	Transposition of Great Vessels	3.4%
436	Hypoplastic Left Heart Syndrome	3.4%
437	May-Thurner Syndrome	3.4%
438	Encephalocele	3.4%
439	Arthralgia	3.4%
440	Polyarthralgia	3.4%
441	Leukomalacia, Periventricular	3.3%
442	POEMS Syndrome	3.3%
443	Rheumatoid Vasculitis	3.3%
444	Nesidioblastosis	3.3%
445	Wolff-Parkinson-White Syndrome	3.3%
446	Ophthalmia Neonatorum	3.3%
447	Renal Osteodystrophy	3.3%
448	Renal rickets	3.3%
449	Aortopulmonary Septal Defect	3%
450	Double Outlet Right Ventricle	3%
451	Endocardial Cushion Defects	3%
452	Myocardial bridging	3%
453	Aorticopulmonary Septal Defect	3%
454	Hyperandrogenism	2.9%
455	Sicca Syndrome	2.9%
456	Sjogren's Syndrome	2.9%
457	Bladder Exstrophy	2.9%
458	Epispadias	2.9%
459	Multicystic Dysplastic Kidney	2.9%
460	Myalgia	2.9%
461	Long QT Syndrome	2.8%
462	Tricuspid Atresia	2.8%
463	Arrhythmogenic Right Ventricular Dysplasia	2.8%
464	Truncus Arteriosus, Persistent	2.8%
465	Gonadal Dysgenesis	2.8%
466	Hip Dislocation	2.8%
467	Shoulder Dislocation	2.8%
468	Adrenogenital Syndrome	2.8%
469	Hip Dysplasia	2.8%
470	Ovotesticular Disorders of Sex Development	2.8%
471	Orbital Myositis	2.7%
472	Dupuytren Contracture	2.7%
473	Pyomyositis	2.7%
474	Kernicterus	2.5%
475	Romano-Ward Syndrome	2.5%
476	Shoulder Pain	2.2%
477	Mitochondrial Encephalomyopathies	1.9%
478	Arteriovenous fistula	1.9%
479	Dermatomyositis	1.7%
480	Radicular Cyst	1.2%
481	Kearns-Sayre syndrome	0.8%

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