MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Eosinophilic Granuloma

(UMLS:C0014461)

Definition:: The most benign and common form of Langerhans-cell histiocytosis which involves localized nodular lesions predominantly of the bones but also of the gastric mucosa, small intestine, lungs, or skin, with infiltration by EOSINOPHILS.
UMLS ID:: C0014461
MeSH ID:: D004803

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.391

Classification 2:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.483.375.500

Classification 3:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.553.231.348|C15.604.250.400.360

Classification 4:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.382.250

Synonym(s)

Eosinophilic Granuloma

Chronic Unifocal Langerhans Cell Histiocytosis

EOSINOPHILIC GRANULOMA

Eosinophilic Xanthomatous Granuloma

Eosinophilic granuloma

Eosinophilic granuloma (clinical)

Eosinophilic xanthomatous granuloma

Monostotic Langerhans Cell Histiocytosis

Unifocal Langerhans Cell Histiocytosis

10.

eosinophilic granuloma

11.

eosinophilic; granuloma

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Phenytoin		3753844	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Leukocytosis	20.1%
2	Pleocytosis	20.1%
3	Pulmonary Eosinophilia	18.5%
4	Eosinophilic Pneumonia	18.5%
5	Granuloma, Respiratory Tract	18%
6	Hypereosinophilic syndrome	17.6%
7	Aseptic Necrosis of Bone	17.2%
8	Eosinophilia-Myalgia Syndrome	16.7%
9	Granuloma, Plasma Cell	15.5%
10	Pyogenic granuloma	15.5%
11	Osteoarthropathy, Secondary Hypertrophic	15.5%
12	Platybasia	15.4%
13	Disseminated Intravascular Coagulation	14.9%
14	Gigantism	14.9%
15	Spinal Neoplasms	14.9%
16	Spondylitis	14.9%
17	Protein S Deficiency	14.9%
18	Thrombocythemia, Essential	13.9%
19	Sarcoidosis, Pulmonary	13.7%
20	Osteochondritis	13.5%
21	Giant Cell Epulis	13.4%
22	Bone Diseases, Developmental	13.4%
23	Hyperostosis	13.4%
24	Osteitis	13.4%
25	Osteitis Deformans	13.4%
26	Osteochondrosis	13.4%
27	Spinal Diseases	13.4%
28	Granuloma, Foreign-Body	13.3%
29	Leukopenia	13.3%
30	Leukostasis	13.3%
31	Infectious Mononucleosis	13.2%
32	Hemoptysis	13%
33	Pneumoconiosis	12.8%
34	Femur Head Necrosis	12.7%
35	Discitis	12.3%
36	Bone Diseases, Endocrine	11.8%
37	Thrombasthenia	11.8%
38	Antithrombin III Deficiency	11.8%
39	Protein C Deficiency	11.8%
40	Ecchymosis	11.6%
41	Petechiae	11.6%
42	Purpura	11.6%
43	Bone Diseases, Infectious	11.6%
44	Bone neoplasms	11.6%
45	Osteopenia	11.6%
46	Polydipsia	11.6%
47	Granuloma Annulare	11.6%
48	Granuloma, Laryngeal	11.5%
49	Bone Resorption	11.5%
50	Histiocytic Disorders, Malignant	11.5%
51	Pelger-Huet Anomaly	11.5%
52	Pectus carinatum	11.4%
53	Infarction	11.4%
54	Postoperative Hemorrhage	11.4%
55	Shock, Hemorrhagic	11.4%
56	Systemic Inflammatory Response Syndrome	11.4%
57	Leukemoid Reaction	11.3%
58	Adenitis	11.2%
59	Anemia	11.2%
60	Blood Coagulation Disorders	11.2%
61	Blood Platelet Disorders	11.2%
62	Bone Marrow Diseases	11.2%
63	Hemorrhagic Disorders	11.2%
64	Lymphadenitis	11.2%
65	Lymphangitis	11.2%
66	Lymphedema	11.2%
67	Methemoglobinemia	11.2%
68	Pancytopenia	11.2%
69	Polycythemia	11.2%
70	Splenic Diseases	11.2%
71	Sulfhemoglobinemia	11.2%
72	Thymus Hyperplasia	11.2%
73	Pseudolymphoma	11.2%
74	Thrombophilia	11.2%
75	Lymphadenopathy	11.2%
76	Erythrocytosis	11.2%
77	Radiation Pneumonitis	11.1%
78	Respiratory Aspiration	11.1%
79	Radiation Fibrosis	11.1%
80	Congenital Hypothyroidism	11%
81	Pectus excavatum	10.9%
82	Tuberculosis, Spinal	10.9%
83	Idiopathic Pulmonary Fibrosis	10.8%
84	Muscle Weakness	10.8%
85	Osteoarthritis, Spine	10.7%
86	Purpura, Thrombotic Thrombocytopenic	10.7%
87	Afibrinogenemia	10.3%
88	Factor VII Deficiency	10.3%
89	Factor X Deficiency	10.3%
90	Factor XII Deficiency	10.3%
91	Hemophilia A	10.3%
92	Activated Protein C Resistance	10.3%
93	Factor II deficiency	10.3%
94	Factor VIII Deficiency	10.3%
95	Factor V deficiency	10.3%
96	Factor XI Deficiency	10.3%
97	Hypoprothrombinemias	10.3%
98	Vascular Remodeling	10.2%
99	Ascites	10.1%
100	Fibrosis	10.1%
101	Gliosis	10.1%
102	Growth Disorders	10.1%
103	Hemorrhage	10.1%
104	Hyperbilirubinemia	10.1%
105	Hyperplasia	10.1%
106	Hypomenorrhea	10.1%
107	Inflammation	10.1%
108	Intraoperative Complications	10.1%
109	Ischemia	10.1%
110	Lithiasis	10.1%
111	Malacoplakia	10.1%
112	Menstruation Disturbances	10.1%
113	Metaplasia	10.1%
114	Nerve Degeneration	10.1%
115	Ochronosis	10.1%
116	Polymenorrhea	10.1%
117	Postoperative Complications	10.1%
118	Sclerosis	10.1%
119	Shock	10.1%
120	Ulcer	10.1%
121	Hyperammonemia	10.1%
122	Hyperamylasemia	10.1%
123	Teratogenesis	10.1%
124	Cardiac Death	10.1%
125	Hypovolemia	10.1%
126	Hyperuricemia	10.1%
127	Leukoaraiosis	10.1%
128	Dysbacteriosis	10.1%
129	Delayed Graft Function	10.1%
130	Cirrhosis	10.1%
131	Neointima	10.1%
132	Dysbiosis	10.1%
133	Agammaglobulinemia	10%
134	Lymphangiectasis, Intestinal	10%
135	Bone Marrow Neoplasms	10%
136	Acute Chest Syndrome	9.9%
137	Ainhum	9.9%
138	Dysostoses	9.9%
139	Spinal Stenosis	9.9%
140	Spondylosis	9.9%
141	Intervertebral Disc Degeneration	9.9%
142	Vitamin K Deficiency	9.9%
143	Transfusion Reaction	9.9%
144	Hypotensive Transfusion Reaction	9.9%
145	Acrocephalosyndactylia	9.8%
146	Lymphocele	9.7%
147	Lymphoproliferative Disorders	9.7%
148	Pneumonia	9.7%
149	Lobar Pneumonia	9.7%
150	Pregnancy Complications, Hematologic	9.7%
151	Respiratory Distress Syndrome, Adult	9.7%
152	Hematologic Neoplasms	9.7%
153	Lymphatic Abnormalities	9.7%
154	Pneumonitis	9.7%
155	Wiskott-Aldrich Syndrome	9.6%
156	Klippel-Feil Syndrome	9.6%
157	Synostosis	9.6%
158	Hemarthrosis	9.6%
159	Thymus Neoplasms	9.6%
160	Ankylosing spondylitis	9.5%
161	Thrombocytosis	9.4%
162	Purpura, Hyperglobulinemic	9.2%
163	Autoimmune thrombocytopenia	9.1%
164	Immune thrombocytopenic purpura	9.1%
165	Arthrogryposis	9.1%
166	Chromosomal Instability	8.9%
167	Extravasation of Diagnostic and Therapeutic Materials	8.9%
168	Neoplastic Processes	8.9%
169	Agranulocytosis	8.8%
170	Lymphocytosis	8.8%
171	Lymphohistiocytosis, Hemophagocytic	8.8%
172	Erdheim-Chester Disease	8.8%
173	Polycythemia Vera	8.7%
174	Necrosis	8.7%
175	Granulomatosis, Orofacial	8.7%
176	Pigmentation Disorders	8.7%
177	Thrombocytopenic purpura	8.7%
178	Spondylarthropathies	8.7%
179	Granulomatosis with polyangiitis	8.7%
180	Craniofacial Dysostosis	8.6%
181	Menorrhagia	8.6%
182	Acantholysis	8.6%
183	Chromosome Aberrations	8.6%
184	Dehydration	8.6%
185	Multiple Epiphyseal Dysplasia	8.6%
186	Osteochondrodysplasias	8.6%
187	Osteomyelitis	8.5%
188	Osteoporosis	8.5%
189	Periostitis	8.5%
190	Bone Demineralization, Pathologic	8.5%
191	Post-Traumatic Osteoporosis	8.5%
192	Lung Diseases, Fungal	8.5%
193	Alveolar Bone Loss	8.5%
194	Osteolysis	8.5%
195	Sudden infant death syndrome	8.5%
196	Arthritis, Psoriatic	8.4%
197	Respiratory Distress Syndrome, Newborn	8.4%
198	Waldenstrom Macroglobulinemia	8.4%
199	Lung Abscess	8.4%
200	Lung Neoplasms	8.4%
201	Atelectasis	8.4%
202	Pulmonary Hypertension	8.4%
203	Pulmonary Alveolar Proteinosis	8.4%
204	Pulmonary Edema	8.4%
205	Pulmonary Fibrosis	8.4%
206	Hamman-Rich syndrome	8.4%
207	Lung Diseases, Obstructive	8.4%
208	Tuberculosis, Pulmonary	8.4%
209	Craniosynostosis	8.4%
210	Syndactyly	8.4%
211	Brachycephaly	8.4%
212	Mucocutaneous Lymph Node Syndrome	8.4%
213	Asbestosis	8.3%
214	Berylliosis	8.3%
215	Silicosis	8.3%
216	Heavy Chain Disease	8.3%
217	Chondrodysplasia Punctata	8.2%
218	Enchondromatosis	8.2%
219	Lordosis	8.2%
220	Osteosclerosis	8.2%
221	Spondylolysis	8.2%
222	kyphosis	8.2%
223	Kashin-Beck Disease	8.2%
224	Purpura Fulminans	8.2%
225	Hemothorax	8.1%
226	Arthritis, Reactive	8.1%
227	Bronchitis	8%
228	Metatarsalgia	8%
229	Epistaxis	7.9%
230	Contracture	7.7%
231	Fasciitis, Plantar	7.7%
232	Dwarfism	7.7%
233	Genomic Instability	7.7%
234	Anti-Glomerular Basement Membrane Disease	7.7%
235	Lymphopenia	7.6%
236	Hypergammaglobulinemia	7.6%
237	Incisional hernia	7.6%
238	jaundice	7.6%
239	Malignant histiocytosis	7.5%
240	Histiocytic sarcoma	7.5%
241	Job Syndrome	7.5%
242	Hemoglobinuria, Paroxysmal	7.5%
243	Transfusion-Related Acute Lung Injury	7.5%
244	Azotemia	7.5%
245	Waterhouse-Friderichsen Syndrome	7.4%
246	Acromegaly	7.4%
247	Joint Tuberculosis	7.4%
248	Tuberculosis, Osteoarticular	7.4%
249	Bone Tuberculosis	7.4%
250	Postoperative Nausea and Vomiting	7.4%
251	Melorheostosis	7.4%
252	Osteopetrosis	7.4%
253	Spondylolisthesis	7.4%
254	Poland Syndrome	7.4%
255	Kernicterus	7.3%
256	Anemia, Diamond-Blackfan	7.3%
257	Lung Injury	7.2%
258	Hepatopulmonary Syndrome	7.2%
259	Pulmonary Embolism	7.1%
260	Bronchopneumonia	7.1%
261	Mediastinal Emphysema	7.1%
262	Asthma	7.1%
263	Pain, Postoperative	7.1%
264	Osteoporosis, Postmenopausal	7%
265	Nose Neoplasms	7%
266	Goldenhar Syndrome	7%
267	Fasciitis	6.9%
268	Foot Deformities	6.9%
269	Arthropathy	6.9%
270	Dysmenorrhea	6.8%
271	Failed Back Surgery Syndrome	6.8%
272	Eye Hemorrhage	6.8%
273	Endotoxic shock	6.8%
274	Septic Shock	6.8%
275	Toxic Shock Syndrome	6.8%
276	Cardiotoxicity	6.8%
277	Fibromyalgia	6.8%
278	Polymyalgia Rheumatica	6.8%
279	Mandibulofacial Dysostosis	6.7%
280	Gout	6.6%
281	Pleuropneumonia	6.6%
282	Ischemic contracture	6.6%
283	Acute Disease	6.6%
284	Acute-Phase Reaction	6.6%
285	Amenorrhea	6.6%
286	Anemia, Hemolytic	6.6%
287	Anemia, Macrocytic	6.6%
288	Chronic disease	6.6%
289	Critical Illness	6.6%
290	Sudden death	6.6%
291	Elephantiasis	6.6%
292	Fat necrosis	6.6%
293	Gangrene	6.6%
294	Graft Occlusion, Vascular	6.6%
295	Hematoma	6.6%
296	Hypersplenism	6.6%
297	Hypoproteinemia	6.6%
298	Iatrogenic Disease	6.6%
299	Multiple Organ Failure	6.6%
300	Oligomenorrhea	6.6%
301	Premenstrual syndrome	6.6%
302	Recurrence	6.6%
303	Retrograde Degeneration	6.6%
304	Retroperitoneal fibrosis	6.6%
305	Sarcoidosis	6.6%
306	Serositis	6.6%
307	Subcutaneous Emphysema	6.6%
308	Surgical Wound Dehiscence	6.6%
309	Syndrome	6.6%
310	Thrombocytopenia	6.6%
311	Wallerian Degeneration	6.6%
312	Exsanguination	6.6%
313	Disease Progression	6.6%
314	Seroma	6.6%
315	Premenstrual Tension	6.6%
316	Delayed Emergence from Anesthesia	6.6%
317	Elephantiasis Nostras Verrucosa	6.6%
318	Infant Death	6.6%
319	Anastomotic Leak	6.6%
320	Intraoperative Awareness	6.6%
321	MYELODYSPLASTIC SYNDROME	6.6%
322	Chronic granulomatous disease	6.6%
323	Anemia, Sickle Cell	6.6%
324	Thalassemia	6.6%
325	Rickets	6.6%
326	Bronchitis, Chronic	6.6%
327	Neutropenia	6.6%
328	Chromosome Fragility	6.6%
329	Temporomandibular Joint Dysfunction Syndrome	6.5%
330	Temporomandibular Joint Disorders	6.4%
331	Antley-Bixler Syndrome Phenotype	6.4%
332	Respiratory Tract Fistula	6.3%
333	Farmer's Lung	6.3%
334	Osteogenesis Imperfecta	6.2%
335	Mastoiditis	6.1%
336	Petrositis	6.1%
337	Scimitar Syndrome	6.1%
338	Hydrops Fetalis	6.1%
339	Jaw Diseases	6%
340	Talipes	6%
341	Pseudohypoparathyroidism	5.9%
342	Cartilage Diseases	5.9%
343	Foot Diseases	5.9%
344	Myopathy	5.9%
345	Rheumatism	5.9%
346	Chondromalacia	5.9%
347	Sick Sinus Syndrome	5.9%
348	Trisomy	5.9%
349	Cryoglobulinemia	5.9%
350	Monoclonal Gammopathy of Undetermined Significance	5.9%
351	Asphyxia	5.9%
352	Shock, Traumatic	5.9%
353	Rheumatic Fever	5.8%
354	Palatal Neoplasms	5.8%
355	Rubinstein-Taybi Syndrome	5.8%
356	Anemia, Neonatal	5.7%
357	Disease susceptibility	5.7%
358	Fetal Death	5.7%
359	Foreign-Body Reaction	5.7%
360	Gastrointestinal Hemorrhage	5.7%
361	Granuloma	5.7%
362	Hemoperitoneum	5.7%
363	Neoplasm Invasiveness	5.7%
364	Neoplasm Metastasis	5.7%
365	Neoplasm Recurrence, Local	5.7%
366	Paraproteinemias	5.7%
367	Postpericardiotomy Syndrome	5.7%
368	Prosthesis Failure	5.7%
369	Reperfusion Injury	5.7%
370	Splenic Infarction	5.7%
371	Splenic Neoplasms	5.7%
372	Injection Site Reaction	5.7%
373	Retrobulbar Hemorrhage	5.7%
374	Peritoneal Fibrosis	5.7%
375	Carcinogenesis	5.7%
376	Neurogenic Inflammation	5.7%
377	Perinatal death	5.7%
378	Infusion site reaction	5.7%
379	Nephrogenic Fibrosing Dermopathy	5.7%
380	Corneal Endothelial Cell Loss	5.7%
381	Encapsulating Peritoneal Sclerosis	5.7%
382	Vasoplegia	5.7%
383	Suppuration	5.7%
384	Nephrogenic Systemic Fibrosis	5.7%
385	Metastasis	5.7%
386	Signs and Symptoms	5.7%
387	Pathological Conditions, Anatomical	5.7%
388	Cystic Fibrosis	5.7%
389	Sinus Arrhythmia	5.7%
390	Atrial Fibrillation	5.7%
391	Atrial Flutter	5.7%
392	Dental Pulp Necrosis	5.7%
393	Hip Contracture	5.7%
394	Periarthritis	5.7%
395	Aspiration Pneumonia	5.7%
396	Surgical Wound Infection	5.7%
397	Tumor Lysis Syndrome	5.7%
398	Ventricular Fibrillation	5.7%
399	Ventricular Flutter	5.7%
400	Parasystole	5.7%
401	Paroxysmal atrial fibrillation	5.7%
402	Facies	5.7%
403	Bradycardia	5.7%
404	Embryo Loss	5.7%
405	Afferent Loop Syndrome	5.7%
406	Sex Chromosome Aberrations	5.7%
407	Short Bowel Syndrome	5.7%
408	Tracheobronchomegaly	5.7%
409	Uterine hemorrhage	5.7%
410	No-Reflow Phenomenon	5.7%
411	Jaundice, Obstructive	5.6%
412	Febrile Neutropenia	5.5%
413	Bronchial Fistula	5.5%
414	Osteomalacia	5.4%
415	Basal Cell Nevus Syndrome	5.4%
416	Sezary Syndrome	5.4%
417	Hematoma, Subdural	5.3%
418	Hematoma, Epidural, Cranial	5.3%
419	Rheumatoid Arthritis	5.2%
420	Juvenile arthritis	5.2%
421	Arthritis, Gouty	5.2%
422	Osteoarthritis, Knee	5.2%
423	Congenital clubfoot	5.2%
424	Vertical Talus	5.2%
425	Bronchial Diseases	5.1%
426	Lymphatic Diseases	5.1%
427	Pleural Diseases	5.1%
428	Respiration Disorders	5.1%
429	Thoracic Diseases	5.1%
430	Tracheal Diseases	5.1%
431	Drowning	5.1%
432	Pneumonia, Viral	5.1%
433	Hemolytic-Uremic Syndrome	5.1%
434	Splenic Rupture	5.1%
435	Marfan Syndrome	5%
436	Pneumonia, Bacterial	5%
437	Fetal Growth Retardation	5%
438	Lymphoma	5%
439	DNA Degradation, Necrotic	5%
440	Aneuploidy	5%
441	Polyploidy	5%
442	Microsatellite Instability	5%
443	Heart Block	5%
444	Tachycardia	5%
445	Tachyarrhythmia	5%
446	Cicatrix	5%
447	Chronic Obstructive Airway Disease	5%
448	Middle Lobe Syndrome	5%
449	Acute Lung Injury	5%
450	Bronchiolitis	5%
451	Hematuria	5%
452	Hyaline Membrane Disease	5%
453	Thymoma	5%
454	Chromosome Breakage	5%
455	Multiple Pulmonary Nodules	4.9%
456	Tissue Adhesions	4.9%
457	Hematoma, Epidural, Spinal	4.9%
458	Brain Death	4.9%
459	Hematemesis	4.9%
460	Shock, Cardiogenic	4.9%
461	Pleurisy	4.8%
462	Tracheitis	4.8%
463	Multiple Myeloma	4.8%
464	Meconium Aspiration Syndrome	4.7%
465	Sickle Cell Trait	4.7%
466	Aspergillosis, Allergic Bronchopulmonary	4.6%
467	Muscle Cramp	4.6%
468	Gastroschisis	4.6%
469	Phantom pain	4.6%
470	Phantom Limb Pain	4.6%
471	Hoarseness	4.5%
472	Rheumatoid Nodule	4.5%
473	Laryngeal Diseases	4.5%
474	Nose Diseases	4.5%
475	Cockayne Syndrome	4.5%
476	Autoimmune Lymphoproliferative Syndrome	4.5%
477	Arthritis	4.5%
478	Bursitis	4.5%
479	Joint Instability	4.5%
480	Myofascial Pain Syndromes	4.5%
481	Rhabdomyolysis	4.5%
482	Synovitis	4.5%
483	Joint laxity	4.5%
484	Polyarthritis	4.5%
485	Frozen shoulder	4.5%
486	Patellofemoral Pain Syndrome	4.5%
487	Respiratory Tract Infections	4.4%
488	Long QT Syndrome	4.4%
489	Laryngomalacia	4.4%
490	Hematoma, Subdural, Intracranial	4.4%
491	Hematoma, Subdural, Chronic	4.4%
492	Hematoma, Subdural, Acute	4.4%
493	Primary Myelofibrosis	4.4%
494	Anemia, Megaloblastic	4.4%
495	Myelofibrosis	4.4%
496	Myeloid Metaplasia	4.4%
497	Hypoalbuminemia	4.4%
498	bone marrow fibrosis	4.4%
499	Thrombotic Microangiopathies	4.4%
500	Respiratory Hypersensitivity	4.4%
501	Fanconi Anemia	4.4%
502	Micronuclei, Chromosome-Defective	4.4%
503	Muscle Rigidity	4.3%
504	Muscle Spasticity	4.3%
505	Cogwheel Rigidity	4.3%
506	Nuchal Rigidity	4.3%
507	Apnea	4.3%
508	Cheyne-Stokes Respiration	4.3%
509	Dyspnea	4.3%
510	Hyperventilation	4.3%
511	Mouth Breathing	4.3%
512	Persistent Fetal Circulation Syndrome	4.3%
513	Tachypnea	4.3%
514	Cross Infection	4.3%
515	Hyphema	4.3%
516	Retinal Neovascularization	4.3%
517	Septicemia	4.3%
518	Vitreous Hemorrhage	4.3%
519	Sepsis	4.3%
520	Pulmonary Aspergillosis	4.3%
521	Bronchopulmonary Aspergillosis	4.3%
522	Laryngitis	4.3%
523	Rhinitis	4.3%
524	Vocal Cord Dysfunction	4.3%
525	Abscess	4.2%
526	Empyema	4.2%
527	Fetal Resorption	4.2%
528	Lymphatic Metastasis	4.2%
529	Neoplasms, Unknown Primary	4.2%
530	Peptic Ulcer Hemorrhage	4.2%
531	Sudden Cardiac Death	4.2%
532	Leukemic Infiltration	4.2%
533	Premenstrual Dysphoric Disorder	4.2%
534	Choroidal Neovascularization	4.2%
535	Primary Graft Dysfunction	4.2%
536	Neoplasm Micrometastasis	4.2%
537	Pulmonary Infarction	4.2%
538	Dumping Syndrome	4.2%
539	Cicatrix, Hypertrophic	4.2%
540	Sinus Arrest, Cardiac	4.2%
541	Metrorrhagia	4.2%
542	Pleural Neoplasms	4.2%
543	Prognathism	4.2%
544	Hematoma, Subdural, Spinal	4.1%
545	Renal Osteodystrophy	4.1%
546	Renal rickets	4.1%
547	Musculoskeletal Pain	4.1%
548	Arthralgia	4%
549	Polyarthralgia	4%
550	Felty Syndrome	4%
551	Subacute Combined Degeneration	4%
552	Atypical Hemolytic Uremic Syndrome	4%
553	Jaw Abnormalities	3.9%
554	Compartment syndromes	3.9%
555	Maxillary Diseases	3.9%
556	Tendinitis	3.9%
557	Tendinopathy	3.9%
558	Myositis	3.8%
559	Tietze's Syndrome	3.8%
560	Limb Deformities, Congenital	3.8%
561	Isaacs syndrome	3.8%
562	Craniofacial Abnormalities	3.8%
563	Myotonic Disorders	3.8%
564	Nasal Polyps	3.8%
565	Retinal Hemorrhage	3.8%
566	Choanal Atresia	3.8%
567	Laryngocele	3.8%
568	Leukemia, Myelomonocytic, Chronic	3.8%
569	Pneumonia, Lipid	3.8%
570	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.8%
571	Choroid Hemorrhage	3.7%
572	Melena	3.7%
573	Tracheal Neoplasms	3.7%
574	Postpartum Hemorrhage	3.7%
575	Gingival Hemorrhage	3.7%
576	Keloid	3.7%
577	Monosomy	3.7%
578	Tetraploidy	3.7%
579	Stillbirth	3.7%
580	Adams-Stokes Syndrome	3.7%
581	Atrioventricular Block	3.7%
582	Bundle-Branch Block	3.7%
583	Atrial Premature Complexes	3.7%
584	Sinoatrial Block	3.7%
585	Tachycardia, Paroxysmal	3.7%
586	Supraventricular tachycardia	3.7%
587	Tachycardia, Ventricular	3.7%
588	Tachycardia, Reciprocating	3.7%
589	Subarachnoid Hemorrhage	3.7%
590	Cerebral Hemorrhage	3.7%
591	Viremia	3.6%
592	Parasitemia	3.6%
593	Rheumatoid Vasculitis	3.6%
594	Blastomycosis	3.6%
595	Myalgia	3.5%
596	Primary Ciliary Dyskinesia	3.5%
597	Laryngeal neoplasm	3.4%
598	Voice Disorders	3.4%
599	Voice Disturbance	3.4%
600	Medial Tibial Stress Syndrome	3.4%
601	Asthenia	3.4%
602	Body Temperature Changes	3.4%
603	Calculi	3.4%
604	Cyanosis	3.4%
605	Edema	3.4%
606	Failure to Thrive	3.4%
607	Fatigue	3.4%
608	Feminization	3.4%
609	Fetal Distress	3.4%
610	Hernia	3.4%
611	Hypertrophy	3.4%
612	Motion Sickness	3.4%
613	Nails, Malformed	3.4%
614	polyps	3.4%
615	Rupture, Spontaneous	3.4%
616	Signs and Symptoms, Digestive	3.4%
617	Signs and Symptoms, Respiratory	3.4%
618	Skin Manifestations	3.4%
619	Chills	3.4%
620	Lassitude	3.4%
621	Enterocele	3.4%
622	Atheroma	3.4%
623	Pseudophakia	3.4%
624	Urological Manifestations	3.4%
625	Stenosis	3.4%
626	Facial asymmetry	3.4%
627	Mobility Limitation	3.4%
628	Somnolence	3.4%
629	Plaque, Amyloid	3.4%
630	Plaque, Atherosclerotic	3.4%
631	Sinusitis	3.3%
632	Mitochondrial Myopathies	3.3%
633	Cellulitis	3.3%
634	Bronchial Neoplasms	3.3%
635	Hypoventilation	3.3%
636	Bunion	3.3%
637	Fibrodysplasia Ossificans Progressiva	3.3%
638	Myoglobinuria	3.3%
639	Myositis Ossificans	3.3%
640	Tenosynovitis	3.3%
641	Sacroiliitis	3.3%
642	Renal Colic	3.3%
643	Shwartzman Phenomenon	3.3%
644	Splenosis	3.3%
645	Pleural Effusion, Malignant	3.3%
646	Abdominal Pain	3.3%
647	Pulmonary Emphysema	3.3%
648	Bronchomalacia	3.3%
649	Tracheomalacia	3.3%
650	Sicca Syndrome	3.3%
651	Sjogren's Syndrome	3.3%
652	Hemangioma, Cavernous	3.3%
653	Hodgkin Disease	3.3%
654	Lymphoma, Non-Hodgkin	3.3%
655	Scurvy	3.3%
656	Leukemia, T-Cell	3.3%
657	Leukemia, B-Cell	3.3%
658	Romano-Ward Syndrome	3.3%
659	Bacteremia	3.1%
660	Micrognathism	3.1%
661	Pierre Robin Syndrome	3.1%
662	Cell Transformation, Viral	3.1%
663	Fungemia	3.1%
664	Shoulder Pain	3.1%
665	Chronic Fatigue Syndrome	3.1%
666	Tachycardia, Atrioventricular Nodal Reentry	3.1%
667	Tachycardia, Ectopic Atrial	3.1%
668	Tachycardia, Ectopic Junctional	3.1%
669	Sinus Tachycardia	3.1%
670	Torsades de Pointes	3.1%
671	Accelerated Idioventricular Rhythm	3.1%
672	Bronchiolitis Obliterans	3%
673	Myotonic Dystrophy	3%
674	Nail-Patella Syndrome	3%
675	Myocardial Reperfusion Injury	3%
676	Cyst	3%
677	Eye Manifestations	3%
678	Neurologic Manifestations	3%
679	Familial Periodic Paralysis	3%
680	POEMS Syndrome	2.9%
681	Composite Lymphoma	2.9%
682	Eye pain	2.9%
683	Lymphangioleiomyomatosis	2.9%
684	Leukoplakia	2.9%
685	Cardiac Output, High	2.9%
686	Myocardial Stunning	2.9%
687	Reticulocytosis	2.9%
688	Low Cardiac Output Syndrome	2.9%
689	Airway Remodeling	2.9%
690	Muscular Atrophy	2.9%
691	Arthritis, Infectious	2.9%
692	Ventricular Remodeling	2.9%
693	Retrognathia	2.9%
694	Alopecia	2.9%
695	Intermittent Claudication	2.9%
696	Androgenetic Alopecia	2.9%
697	Anterior Compartment Syndrome	2.8%
698	Enthesopathy	2.8%
699	Arthritis, Experimental	2.8%
700	Abdominal Compartment Syndrome	2.8%
701	Amelia	2.8%
702	Arachnodactyly	2.8%
703	Bronchopulmonary Dysplasia	2.8%
704	Ectromelia	2.8%
705	Hemimelia	2.8%
706	Phocomelia	2.8%
707	Sirenomelia	2.8%
708	Polymyositis	2.8%
709	Polydactyly	2.8%
710	Brachydactyly	2.8%
711	Plagiocephaly	2.8%
712	Lower Extremity Deformities, Congenital	2.8%
713	Upper Extremity Deformities, Congenital	2.8%
714	Leukemia, Myeloid, Chronic-Phase	2.8%
715	Anemia, Pernicious	2.8%
716	Altitude Sickness	2.8%
717	Bronchospasm	2.8%
718	Bronchiectasis	2.8%
719	Chylothorax	2.8%
720	Histiocytosis	2.8%
721	Hydropneumothorax	2.8%
722	Hydrothorax	2.8%
723	Leukocyte Disorders	2.8%
724	Pneumothorax	2.8%
725	Respiratory Insufficiency	2.8%
726	Tracheal Stenosis	2.8%
727	Bronchial Hyperreactivity	2.8%
728	Respiratory Depression	2.8%
729	Respiratory Failure	2.8%
730	Rhinoscleroma	2.8%
731	Endotoxemia	2.8%
732	Vocal Cord Paralysis	2.7%
733	Philadelphia Chromosome	2.6%
734	Abdomen, Acute	2.6%
735	Niemann-Pick Disease, Type C	2.6%
736	Kartagener Syndrome	2.5%
737	Familial Hypophosphatemic Rickets	2.5%
738	Hip Dislocation	2.5%
739	Shoulder Dislocation	2.5%
740	Hip Dysplasia	2.5%
741	Muscular Dystrophy	2.5%
742	Orbital Myositis	2.5%
743	Dupuytren Contracture	2.5%
744	Diverticulum	2.5%
745	Laryngospasm	2.5%
746	Diverticulosis	2.5%
747	Paranasal Sinus Neoplasms	2.5%
748	Dyspnea, Paroxysmal	2.5%
749	Respiratory Paralysis	2.5%
750	Pyomyositis	2.5%
751	Asthma, Exercise-Induced	2.5%
752	Status Asthmaticus	2.5%
753	Invasive Pulmonary Aspergillosis	2.5%
754	Cleft Palate	2.5%
755	Lymphoma, Follicular	2.4%
756	T-Cell Lymphoma	2.4%
757	Mantle cell lymphoma	2.4%
758	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
759	Leukemia, Large Granular Lymphocytic	2.4%
760	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
761	Granuloma, Lethal Midline	2.4%
762	Laryngeal Edema	2.4%
763	Nose Deformities, Acquired	2.4%
764	Common Cold	2.4%
765	Influenza	2.4%
766	Catarrh	2.4%
767	Severe Acute Respiratory Syndrome	2.4%
768	Laryngopharyngeal Reflux	2.4%
769	Asthma, Occupational	2.3%
770	Sarcopenia	2.2%
771	Pseudoxanthoma Elasticum	2.2%
772	Maxillofacial Abnormalities	2.2%
773	Anorexia	2.2%
774	Anoxia	2.2%
775	Constipation	2.2%
776	Diarrhea	2.2%
777	Dyspepsia	2.2%
778	Eructation	2.2%
779	Fever	2.2%
780	Flatulence	2.2%
781	Flushing	2.2%
782	Halitosis	2.2%
783	Heartburn	2.2%
784	Diaphragmatic Hernia	2.2%
785	Hiccough	2.2%
786	Hypercalciuria	2.2%
787	Hypercapnia	2.2%
788	Hyperphagia	2.2%
789	Intestinal Polyps	2.2%
790	Nausea	2.2%
791	Pallor	2.2%
792	Psychophysiologic Disorders	2.2%
793	Splenomegaly	2.2%
794	Vomiting	2.2%
795	Hypocapnia	2.2%
796	Dyschezia	2.2%
797	Hypoxia	2.2%
798	Hyperoxia	2.2%
799	Lower Urinary Tract Symptoms	2.2%
800	Hypoxemia	2.2%
801	Urinoma	2.2%
802	Basal Ganglia Hemorrhage	2.2%
803	Aphonia	2.2%
804	Myotonia Congenita	2.2%
805	Dysphonia	2.2%
806	Candidemia	2.2%
807	Microcephaly	2.2%
808	Macrocephaly	2.2%
809	Hypokalemic periodic paralysis	2.2%
810	Pharyngitis	2.1%
811	Laryngostenosis	2.1%
812	Pertussis	2.1%
813	Welander Distal Myopathy	2.1%
814	Lymphoma, T-Cell, Cutaneous	2%
815	Lymphoma, AIDS-Related	2%
816	Enteropathy-Associated T-Cell Lymphoma	2%
817	Primary Effusion Lymphoma	2%
818	Gait Ataxia	2%
819	Asthma, Aspirin-Induced	2%
820	Putaminal Hemorrhage	2%
821	Body Weight	2%
822	Mitochondrial Encephalomyopathies	2%
823	Decerebrate State	1.9%
824	Cardiomegaly	1.9%
825	Hemiparesis	1.9%
826	Hepatomegaly	1.9%
827	Meningism	1.9%
828	Paresis	1.9%
829	Parovarian Cyst	1.9%
830	Pruritus	1.9%
831	Seizures	1.9%
832	Sensation Disorders	1.9%
833	Sneezing	1.9%
834	Spermatocele	1.9%
835	Erythema	1.9%
836	Oral Fistula	1.9%
837	Complex partial seizures	1.9%
838	Necrolytic Migratory Erythema	1.9%
839	Monoparesis	1.9%
840	Cutaneous Fistula	1.9%
841	Gait Disorders, Neurologic	1.9%
842	Neuromuscular Manifestations	1.9%
843	Cardiac Hypertrophy	1.9%
844	Edema, Cardiac	1.9%
845	Mental Fatigue	1.9%
846	Hirsutism	1.9%
847	Orthostatic intolerance	1.9%
848	Vaginal Fistula	1.9%
849	Rectocele	1.9%
850	Body Weight Changes	1.9%
851	Dermatomyositis	1.9%
852	Muscular Dystrophy, Duchenne	1.8%
853	Mycosis Fungoides	1.8%
854	Lymphomatoid Papulosis	1.8%
855	Plasmablastic lymphoma	1.8%
856	Lymphomatoid Granulomatosis	1.8%
857	Hay fever	1.8%
858	Rhinitis, Allergic, Perennial	1.8%
859	Noonan Syndrome	1.8%
860	Porencephaly	1.8%
861	Akathisia	1.8%
862	Restlessness	1.8%
863	Psychomotor Agitation	1.8%
864	Vesicovaginal Fistula	1.8%
865	Sleep Wake Disorders	1.7%
866	Pupil Disorders	1.7%
867	Neurobehavioral Manifestations	1.7%
868	Gait Apraxia	1.7%
869	Pleural Rub	1.7%
870	Rales	1.7%
871	Respiratory Sounds	1.7%
872	Rhonchi	1.7%
873	Stridor	1.7%
874	Wheezing	1.7%
875	Asterixis	1.7%
876	Ballismus	1.7%
877	Vertigo	1.7%
878	Pain	1.7%
879	Livedo Reticularis	1.7%
880	Ache	1.7%
881	Airway Obstruction	1.7%
882	Choking	1.7%
883	Eosinophilia	1.7%
884	Epiglottitis	1.7%
885	Mediastinitis	1.7%
886	Meningocele	1.7%
887	Oliguria	1.7%
888	Polyuria	1.7%
889	Proteinuria	1.7%
890	Urinary Calculi	1.7%
891	Holoprosencephaly	1.7%
892	Encephalocele	1.7%
893	Back Pain	1.6%
894	Bulimia	1.6%
895	Neck Pain	1.6%
896	Chest Pain	1.6%
897	Colonic Polyps	1.6%
898	Dizziness	1.6%
899	Dysuria	1.6%
900	Facial Pain	1.6%
901	Fever of Unknown Origin	1.6%
902	Flank Pain	1.6%
903	Headache	1.6%
904	Nocturia	1.6%
905	Pain, Intractable	1.6%
906	Pelvic Pain	1.6%
907	Snoring	1.6%
908	Chronic pain	1.6%
909	Lightheadedness	1.6%
910	Pain, Referred	1.6%
911	Prostatism	1.6%
912	Throbbing Headache	1.6%
913	Labor Pain	1.6%
914	Cancer Pain	1.6%
915	Nociceptive Pain	1.6%
916	Underweight	1.6%
917	Overweight	1.6%
918	Burkitt Lymphoma	1.6%
919	Maxillary Sinus Neoplasms	1.6%
920	Kearns-Sayre syndrome	1.6%
921	Gagging	1.5%
922	Alice in Wonderland Syndrome	1.5%
923	Leukoplakia, Oral	1.5%
924	Radicular Cyst	1.5%
925	Alexia	1.5%
926	Dyslexia	1.5%
927	Mediastinal Cyst	1.4%
928	Pericardial Cyst	1.4%
929	Thymic Cyst	1.4%
930	Biliary Fistula	1.4%
931	Gastric Fistula	1.4%
932	Congenital diaphragmatic hernia	1.4%
933	Morning Sickness	1.4%
934	Croup	1.4%
935	Histiocytosis, Langerhans-Cell	1.4%
936	Rhinitis, Vasomotor	1.4%
937	Acidosis, Respiratory	1.4%
938	Alkalosis, Respiratory	1.4%
939	Anosmia	1.4%
940	Ataxia	1.4%
941	Athetosis	1.4%
942	Catalepsy	1.4%
943	Dental Fistula	1.4%
944	Dystonia	1.4%
945	Hemiplegia	1.4%
946	Locked-In Syndrome	1.4%
947	Muscle Hypertonia	1.4%
948	Muscle hypotonia	1.4%
949	Myoclonus	1.4%
950	Myotonia	1.4%
951	Neuralgia	1.4%
952	Oroantral Fistula	1.4%
953	Paraplegia	1.4%
954	Pseudobulbar Palsy	1.4%
955	Quadriplegia	1.4%
956	Sleep Apnea Syndromes	1.4%
957	Spasm	1.4%
958	Spastic Paraplegia	1.4%
959	Status Epilepticus	1.4%
960	Taste Disorders	1.4%
961	Tremor	1.4%
962	Monoplegia	1.4%
963	Hypokinesia	1.4%
964	Left Ventricular Hypertrophy	1.4%
965	Gastroparesis	1.4%
966	Right Ventricular Hypertrophy	1.4%
967	Paraparesis	1.4%
968	Bradykinesia	1.4%
969	Waxy flexibility	1.4%
970	Action Tremor	1.4%
971	Resting Tremor	1.4%
972	Dysosmia	1.4%
973	Quadriparesis	1.4%
974	Olfaction Disorders	1.4%
975	Myokymia	1.4%
976	Somatosensory Disorders	1.4%
977	Neuropathic pain	1.4%
978	Hyperkinesia	1.4%
979	Intention tremor	1.4%
980	Rectal Prolapse	1.4%
981	Uterine Prolapse	1.4%
982	Vaginal Prolapse	1.4%
983	Weight Gain	1.4%
984	Emaciation	1.4%
985	Low Back Pain	1.4%
986	Visceral Pain	1.4%
987	Jet Lag Syndrome	1.3%
988	Eosinophilic Granuloma	1.3%
989	Reflex, Abnormal	1.3%
990	Hyporeflexia	1.3%
991	Hyperreflexia	1.3%
992	Birth Weight	1.3%
993	Vision Disorders	1.3%
994	Metamorphopsia	1.3%
995	Visual Impairment	1.3%
996	Pancreatic Fistula	1.3%
997	Anisocoria	1.3%
998	Confusion	1.3%
999	Facial paralysis	1.3%
1000	Intestinal Fistula	1.3%
1001	Lethargy	1.3%
1002	Memory Disorders	1.3%
1003	Perceptual Disorders	1.3%
1004	Psychomotor Disorders	1.3%
1005	Tonic Pupil	1.3%
1006	Anhedonia	1.3%
1007	Disorientation	1.3%
1008	Enterocutaneous Fistula	1.3%
1009	Fetal Hypoxia	1.3%
1010	Facial Paresis	1.3%
1011	Memory Loss	1.3%
1012	Hemisensory Neglect	1.3%
1013	Dysacusis	1.3%
1014	Tonsillitis	1.2%
1015	Mastodynia	1.2%
1016	Salivary Gland Fistula	1.2%
1017	Chorea	1.2%
1018	Cystocele	1.2%
1019	Tetany	1.2%
1020	Urinary Incontinence	1.2%
1021	Breakthrough Pain	1.2%
1022	Cachexia	1.2%
1023	Albuminuria	1.2%
1024	Hemoglobinuria	1.2%
1025	Umbilical hernia	1.2%
1026	Toothache	1.2%
1027	Hyperemesis Gravidarum	1.2%
1028	Dysgeusia	1.2%
1029	Formication	1.2%
1030	Hyperalgesia	1.2%
1031	Hyperesthesia	1.2%
1032	Hypesthesia	1.2%
1033	Language Disorders	1.2%
1034	Numbness	1.2%
1035	Paresthesia	1.2%
1036	Paraparesis, Spastic	1.2%
1037	Trismus	1.2%
1038	Epilepsia Partialis Continua	1.2%
1039	Hypogeusia	1.2%
1040	Brown-Sequard Syndrome	1.2%
1041	Lockjaw	1.2%
1042	Allodynia	1.2%
1043	Ageusia	1.2%
1044	MELAS Syndrome	1.2%
1045	Consciousness Disorders	1.1%
1046	Mental Retardation	1.1%
1047	Depressed Level of Consciousness	1.1%
1048	Mental deficiency	1.1%
1049	Intellectual Disability	1.1%
1050	Catatonia	1.1%
1051	Ophthalmoplegia	1.1%
1052	External Ophthalmoplegia	1.1%
1053	Sleep Deprivation	1.1%
1054	Retropharyngeal Abscess	1.1%
1055	Cerebrospinal Fluid Otorrhea	1.1%
1056	Cerebrospinal Fluid Rhinorrhea	1.1%
1057	Fetal Weight	1.1%
1058	Obesity	1.1%
1059	Agraphia	1.1%
1060	Anomia	1.1%
1061	Cluttering	1.1%
1062	Language Development Disorders	1.1%
1063	Speech Disorders	1.1%
1064	Syncope	1.1%
1065	Stupor	1.1%
1066	Dysgraphia	1.1%
1067	Presyncope	1.1%
1068	Dyslalia	1.1%
1069	Diplopia	1%
1070	Scotoma	1%
1071	Photophobia	1%
1072	Hemifacial Spasm	1%
1073	Amaurosis	1%
1074	Blindness	1%
1075	Angina Pectoris	1%
1076	Agnosia	1%
1077	Apraxias	1%
1078	Hallucinations	1%
1079	Hemianopsia	1%
1080	Hyperacusis	1%
1081	Tinnitus	1%
1082	Visual Agnosia	1%
1083	Anosognosia	1%
1084	Wernicke-Korsakoff Syndrome	1%
1085	Phonophobia	1%
1086	Hearing Loss	1%
1087	Cerebellar Ataxia	1%
1088	Torticollis	1%
1089	Sciatica	1%
1090	Urge Incontinence	1%
1091	Tardive Dyskinesia	1%
1092	Nasopharyngitis	1%
1093	Aphasia	1%
1094	Articulation Disorders	1%
1095	Echolalia	1%
1096	Stuttering	1%
1097	Dysphasia	1%
1098	Urinary Bladder Fistula	1%
1099	Tinea Pedis	1%
1100	Dysarthria	1%
1101	Sleep Apnea, Obstructive	0.9%
1102	Sleep Apnea, Central	0.9%
1103	Amaurosis Fugax	0.9%
1104	Blindness, Cortical	0.9%
1105	Dyscalculia	0.9%
1106	Amblyopia	0.9%
1107	Amnesia	0.9%
1108	Delirium	0.9%
1109	Horner Syndrome	0.9%
1110	Dissociative Amnesia	0.9%
1111	Color blindness	0.9%
1112	Global Amnesia	0.9%
1113	Angina, Unstable	0.9%
1114	Deafness	0.9%
1115	Hearing Loss, Sudden	0.9%
1116	Gerstmann Syndrome	0.9%
1117	Hearing Loss, Bilateral	0.9%
1118	Hearing Loss, High-Frequency	0.9%
1119	Hearing Loss, Mixed Conductive-Sensorineural	0.9%
1120	Prosopagnosia	0.9%
1121	Apraxia, Ideomotor	0.9%
1122	Persistent Vegetative State	0.9%
1123	Charles Bonnet Syndrome	0.9%
1124	Hearing Loss, Unilateral	0.9%
1125	Complete Hearing Loss	0.9%
1126	Alien Hand Syndrome	0.9%
1127	Deaf Mutism	0.9%
1128	Dyskinesia, Drug-Induced	0.9%
1129	Rectal Fistula	0.9%
1130	Anal Fistula	0.9%
1131	Pediatric Obesity	0.9%
1132	Alcohol Withdrawal Seizures	0.9%
1133	Arteriovenous fistula	0.9%
1134	Mutism	0.9%
1135	Selective Mutism	0.9%
1136	Angina Pectoris, Variant	0.9%
1137	Alexia, Pure	0.8%
1138	Akathisia, Drug-Induced	0.8%
1139	Retrograde amnesia	0.8%
1140	Amnesia, Anterograde	0.8%
1141	Kidney Calculi	0.8%
1142	Ureteral Calculi	0.8%
1143	Auditory Perceptual Disorders	0.7%
1144	Amnesia, Transient Global	0.7%
1145	Peritonsillar Abscess	0.7%
1146	Ophthalmoplegic Migraine	0.7%
1147	Progressive supranuclear palsy	0.7%

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