MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Thiamine

(JZRWCGZRTZMZEH-UHFFFAOYSA-N)

Structure

SMILES: OCCc1sc[n+](c1C)Cc1cnc(nc1N)C
Type(s): Approved; Investigational; Nutraceutical; Vet_approved
ATC code(s): A11DA01
Molecular Formula:: C12H17N4OS+
Molecular Weight:: 265.355
Log P:: 1.1889
Hydrogen Bond Acceptor:: 5
Hydrogen Bond Donor:: 2
TPSA:: 104.15
CAS Number(s):: 70-16-6

Synonym(s)

Thiamine

Aneurin

Vitamin B 1

Thiamin

Thiamine Mononitrate

Vitamin B1

Mononitrate, Thiamine

External Link(s)

MeSH	D013831
PubChem Compound	1130
BindingDB	50373877
ChEBI	18385
CHEMBL	CHEMBL1547
DrugBank	DB00152
DrugCentral	2832
IUPHAR/BPS Guide to PHARMACOLOGY	4628 4629
KEGG	cpd:C00378
Therapeutic Target Database	D06PQT D07TYL
ZINC	49153

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Drooling	FAERS: 2		US FAERS
2	Dysarthria	FAERS: 2		US FAERS
3	Product label issue	FAERS: 2		US FAERS
4	Anaphylactic shock	FAERS: 1		SIDER US FAERS
5	Atrial Fibrillation	FAERS: 1		US FAERS
6	Cardiac Arrest	FAERS: 1		US FAERS
7	Circumstance or information capable of leading to medication error	FAERS: 1		OFFSIDES US FAERS
8	Product barcode issue	FAERS: 1		US FAERS
9	Pruritus	FAERS: 1		SIDER US FAERS
10	Unresponsive to stimuli	FAERS: 1		OFFSIDES US FAERS
11	Urticaria	FAERS: 1	11792017	CTD SIDER US FAERS
12	Abasia			OFFSIDES
13	Abdominal Compartment Syndrome			OFFSIDES
14	Abdominal rigidity			OFFSIDES
15	Abulia			OFFSIDES
16	Accidental death			OFFSIDES
17	Accidental exposure			OFFSIDES
18	Acidosis		8765181	CTD OFFSIDES
19	Activities of daily living impaired			OFFSIDES
20	Acute myocardial infarction			OFFSIDES
21	Adenoma			OFFSIDES
22	Agitation			SIDER
23	Agraphia			OFFSIDES
24	Alanine Aminotransferase Increased			OFFSIDES
25	Alcohol Withdrawal Delirium		6122874 7220787	CTD
26	Alcohol abuse			OFFSIDES
27	Alcohol consumption			OFFSIDES
28	Alcohol poisoning			OFFSIDES
29	Alcohol withdrawal syndrome			OFFSIDES
30	Alcoholic Intoxication			OFFSIDES
31	Aldolase increased			OFFSIDES
32	Alveolitis			OFFSIDES
33	Amnesia			OFFSIDES
34	Amphetamines			OFFSIDES
35	Angioedema			OFFSIDES SIDER
36	Anisocoria			OFFSIDES
37	Anorexia			OFFSIDES
38	Antinuclear antibody increased			OFFSIDES
39	Antipsychotic drug level increased			OFFSIDES
40	Aortic Aneurysm			OFFSIDES
41	Apathy			OFFSIDES
42	Aphonia			OFFSIDES
43	Arteriosclerosis			OFFSIDES
44	Ascites			OFFSIDES
45	Aspergillosis			OFFSIDES
46	Aspiration Pneumonia			OFFSIDES
47	Asthenia			OFFSIDES SIDER
48	Ataxia			OFFSIDES
49	Atelectasis			OFFSIDES
50	Athetosis			OFFSIDES
51	Atrial natriuretic peptide increased			OFFSIDES
52	Atrial tachycardia			OFFSIDES
53	Aura			OFFSIDES
54	Bacteria sputum identified			OFFSIDES
55	Basal cell carcinoma			OFFSIDES
56	Bedridden			OFFSIDES
57	Benign Prostatic Hyperplasia			OFFSIDES
58	Beriberi		31419397	CTD
59	Biopsy			OFFSIDES
60	Bipolar Disorder		7568661	CTD OFFSIDES
61	Blood Glucose			OFFSIDES
62	Blood albumin decreased			OFFSIDES
63	Blood albumin increased			OFFSIDES
64	Blood chloride decreased			OFFSIDES
65	Blood creatine phosphokinase increased			OFFSIDES
66	Blood creatinine decreased			OFFSIDES
67	Blood fibrinogen increased			OFFSIDES
68	Blood lactate dehydrogenase increased			OFFSIDES
69	Blood osmolarity increased			OFFSIDES
70	Blood potassium decreased			OFFSIDES
71	Blood sodium			OFFSIDES
72	Blood thyroid stimulating hormone			OFFSIDES
73	Blurred vision			OFFSIDES
74	Body Temperature			OFFSIDES
75	Bone erosion			OFFSIDES
76	Bradycardia			OFFSIDES
77	Brain Death			OFFSIDES
78	Brain Diseases		14555540	CTD
79	Bronchiectasis			OFFSIDES
80	Bronchiolitis			OFFSIDES
81	Bronchopneumonia			OFFSIDES
82	CD4 Lymphocytes Decreased			OFFSIDES
83	Candidiasis of vagina			OFFSIDES
84	Cardiac Tamponade			OFFSIDES
85	Cardiac perforation			OFFSIDES
86	Cardioactive drug level			OFFSIDES
87	Cardiomyopathies		6938188 31419397	CTD
88	Cataract		11438049	CTD OFFSIDES
89	Catatonia			OFFSIDES
90	Catheter placement			OFFSIDES
91	Catheter related complication			OFFSIDES
92	Cellulitis			OFFSIDES
93	Cerebellar Ataxia		4022349	CTD OFFSIDES
94	Cerebral artery stenosis			OFFSIDES
95	Cerebral atrophy			OFFSIDES
96	Cerebrosclerosis			OFFSIDES
97	Cervical myelopathy			OFFSIDES
98	Cheilitis			OFFSIDES
99	Chemotherapeutic drug level increased			OFFSIDES
100	Child Nutrition Disorders		16153327	CTD
101	Choking sensation			OFFSIDES
102	Chronic Obstructive Airway Disease			OFFSIDES
103	Cirrhosis			OFFSIDES
104	Cleft Palate		14991264	CTD
105	Completed Suicide			OFFSIDES
106	Confabulation			OFFSIDES
107	Congenital tricuspid valve incompetence			OFFSIDES
108	Contact lens complication			OFFSIDES
109	Conversion disorder			OFFSIDES
110	Corneal Ulcer			OFFSIDES
111	Cyanosis			SIDER
112	Cytolytic hepatitis			OFFSIDES
113	Deafness			OFFSIDES
114	Dehydration			OFFSIDES
115	Demyelinating Diseases		9224999	CTD
116	Demyelination			OFFSIDES
117	Dental caries			OFFSIDES
118	Depressed Level of Consciousness			OFFSIDES
119	Depressed mood			OFFSIDES
120	Dermatomyositis			OFFSIDES
121	Device breakage			OFFSIDES
122	Diabetic Foot			OFFSIDES
123	Diabetic Nephropathy			OFFSIDES
124	Diabetic ulcer			OFFSIDES
125	Diplopia			OFFSIDES
126	Disease recurrence			OFFSIDES
127	Diverticular perforation			OFFSIDES
128	Diverticulosis			OFFSIDES
129	Dizziness			OFFSIDES
130	Drowsiness			OFFSIDES
131	Drug Eruptions		11792017	CTD
132	Drug abuser			OFFSIDES
133	Drug addict			OFFSIDES
134	Drug administration error			OFFSIDES
135	Drug screen positive			OFFSIDES
136	Drug toxicity			OFFSIDES
137	Duodenal Ulcer			OFFSIDES
138	Dysthymic Disorder			OFFSIDES
139	Eclampsia			OFFSIDES
140	Economic problem			OFFSIDES
141	Electrocardiogram ST-T change			OFFSIDES
142	Electrocardiogram T wave peaked			OFFSIDES
143	Electromechanical dissociation			OFFSIDES
144	Encephalitis		5481417	CTD
145	Endophthalmitis			OFFSIDES
146	Enterobacter pneumonia			OFFSIDES
147	Eosinophilic myocarditis			OFFSIDES
148	Epididymitis			OFFSIDES
149	Escherichia infection			OFFSIDES
150	Extremity necrosis			OFFSIDES
151	Fatty Liver			OFFSIDES
152	Febrile Neutropenia			OFFSIDES
153	Feeding tube complication			OFFSIDES
154	Fibromyalgia			OFFSIDES
155	Flat affect			OFFSIDES
156	Folliculitis			OFFSIDES
157	Formication			OFFSIDES
158	Gamma-Glutamyltransferase Increased			OFFSIDES
159	Gastroschisis			OFFSIDES
160	Genital Herpes			OFFSIDES
161	Granulocytosis			OFFSIDES
162	Hallucinations, mixed			OFFSIDES
163	Heart failure		1414337	CTD
164	Hemiparesis			OFFSIDES
165	Hemisensory Neglect			OFFSIDES
166	Heparin-induced thrombocytopenia			OFFSIDES
167	Hepatic Encephalopathy		20163200	CTD
168	Hepatic necrosis			OFFSIDES
169	Hepatitis			OFFSIDES
170	Hydrocephalus			OFFSIDES
171	Hyperparathyroidism			OFFSIDES
172	Hyperreflexia			OFFSIDES
173	Hypersensitivity			SIDER
174	Hypertensive cardiomyopathy			OFFSIDES
175	Hypertensive heart disease			OFFSIDES
176	Hypoxia			OFFSIDES
177	Iliac artery stenosis			OFFSIDES
178	Immunosuppression			OFFSIDES
179	Impaired self-care			OFFSIDES
180	Incontinence			OFFSIDES
181	Induration			SIDER
182	Infection			OFFSIDES
183	Intentional self-injury			OFFSIDES
184	Intercepted medication error			OFFSIDES
185	Intermittent Claudication			OFFSIDES
186	Intervertebral Disc Degeneration			OFFSIDES
187	Joint prosthesis user			OFFSIDES
188	Kidney Failure			OFFSIDES
189	Laceration			OFFSIDES
190	Lead Poisoning		10928693	CTD
191	Lethargy			OFFSIDES
192	Leukopenia neonatal			OFFSIDES
193	Lichen Planus			OFFSIDES
194	Live Birth			OFFSIDES
195	Liver Abscess			OFFSIDES
196	Lung infection pseudomonal			OFFSIDES
197	Lymph nodes scan abnormal			OFFSIDES
198	Lymphocyte count decreased			OFFSIDES
199	Lymphocyte percentage decreased			OFFSIDES
200	Lymphoma			OFFSIDES
201	MELAS Syndrome			OFFSIDES
202	Mastication disorder			OFFSIDES
203	Mechanical ventilation			OFFSIDES
204	Mental Retardation			OFFSIDES
205	Mental status changes			OFFSIDES
206	Metabolic acidosis			OFFSIDES
207	Metamyelocyte count increased			OFFSIDES
208	Metastatic Neoplasm			OFFSIDES
209	Metastatic bronchial carcinoma			OFFSIDES
210	Mitochondrial Myopathies		6938188	CTD
211	Mononeuritis			OFFSIDES
212	Motion Sickness			OFFSIDES
213	Multiple Myeloma			OFFSIDES
214	Multiple drug overdose			OFFSIDES
215	Muscle necrosis			OFFSIDES
216	Musculoskeletal Pain			OFFSIDES
217	Myasthenic Syndrome			OFFSIDES
218	Myelocyte count increased			OFFSIDES
219	Myositis Ossificans			OFFSIDES
220	Nausea			SIDER
221	Neoplasms		6061664	CTD
222	Nephrogenic Diabetes Insipidus			OFFSIDES
223	Nerve Degeneration		18481165	CTD
224	Neuralgia			OFFSIDES
225	Neuroleptic Malignant Syndrome			OFFSIDES
226	Neurological examination abnormal			OFFSIDES
227	Neutrophil count decreased			OFFSIDES
228	Non-cardiac chest pain			OFFSIDES
229	Nystagmus			OFFSIDES
230	Open wound			OFFSIDES
231	Oral polypectomy			OFFSIDES
232	Orthopnea			OFFSIDES
233	Orthosis user			OFFSIDES
234	Osteolysis			OFFSIDES
235	Osteosclerosis			OFFSIDES
236	Overdose			OFFSIDES
237	Overweight			OFFSIDES
238	Pain		11516431	CTD OFFSIDES
239	Paranoia			OFFSIDES
240	Paraplegia			OFFSIDES
241	Pelvic fluid collection			OFFSIDES
242	Peripheral Nervous System Diseases		6287825 16285603	CTD
243	Phantom pain			OFFSIDES
244	Pneumothorax			OFFSIDES
245	Polysubstance dependence			OFFSIDES
246	Portal hypertensive gastropathy			OFFSIDES
247	Post procedural complication			OFFSIDES
248	Postoperative infection			OFFSIDES
249	Pre-Eclampsia			OFFSIDES
250	Prescribed overdose			OFFSIDES
251	Primary sequestrum			OFFSIDES
252	Productive Cough			OFFSIDES
253	Pseudomonal sepsis			OFFSIDES
254	Pulmonary congestion			OFFSIDES
255	Pulmonary malformation			OFFSIDES
256	Pulmonary radiation injury			OFFSIDES
257	Purulence			OFFSIDES
258	Pyelonephritis			OFFSIDES
259	Rectal polyp			OFFSIDES
260	Renal tubular necrosis			OFFSIDES
261	Respiratory Failure			OFFSIDES
262	Retroperitoneal lymphadenopathy			OFFSIDES
263	Rhabdomyolysis			OFFSIDES
264	Rheumatoid Nodule			OFFSIDES
265	Rhinorrhea			OFFSIDES
266	Right atrial dilatation			OFFSIDES
267	Risus sardonicus			OFFSIDES
268	Schizoaffective Disorder			OFFSIDES
269	Schizophrenia			OFFSIDES
270	Seizures		1463588	CTD
271	Self Mutilation			OFFSIDES
272	Sensation of warmth			SIDER
273	Septic Shock			OFFSIDES
274	Sequestrectomy			OFFSIDES
275	Sexual abuse			OFFSIDES
276	Shock			SIDER
277	Sinus headache			OFFSIDES
278	Sinusitis			OFFSIDES
279	Skin lesion			OFFSIDES
280	Skin toxicity			OFFSIDES
281	Soft Tissue Infection			OFFSIDES
282	Sperm count decreased			OFFSIDES
283	Sputum culture positive			OFFSIDES
284	Status Epilepticus			OFFSIDES
285	Sudden death			OFFSIDES
286	Sweating			SIDER
287	Synovitis			OFFSIDES
288	Tendinitis			OFFSIDES
289	Tetany			OFFSIDES
290	Thalamic infarction			OFFSIDES
291	Therapeutic response unexpected			OFFSIDES
292	Thromboangiitis Obliterans			OFFSIDES
293	Thrombotic stroke			OFFSIDES
294	Tinea Pedis			OFFSIDES
295	Tinea Versicolor			OFFSIDES
296	Tinea cruris			OFFSIDES
297	Tooth Extraction			OFFSIDES
298	Tooth Loss			OFFSIDES
299	Toxicologic test abnormal			OFFSIDES
300	Transaminases increased			OFFSIDES
301	Troponin increased			OFFSIDES
302	Urine flow decreased			OFFSIDES
303	Vaginal cellulitis			OFFSIDES
304	Vascular insufficiency			OFFSIDES
305	Vulvovaginal discomfort			OFFSIDES
306	Wernicke Encephalopathy		View details 2499199 6410237 8765181 14644703 17583600 19654964 20426524	CTD
307	Wound Infection			OFFSIDES
308	Xanthopsia			OFFSIDES
309	colonoscopy			OFFSIDES
310	jejunitis			OFFSIDES

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