MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Fragile X Syndrome

(UMLS:C0016667)

Definition:: A condition characterized genotypically by mutation of the distal end of the long arm of the X chromosome (at gene loci FRAXA or FRAXE) and phenotypically by cognitive impairment, hyperactivity, SEIZURES, language delay, and enlargement of the ears, head, and testes. INTELLECTUAL DISABILITY occurs in nearly all males and roughly 50% of females with the full mutation of FRAXA. (From Menkes, Textbook of Child Neurology, 5th ed, p226)
UMLS ID:: C0016667
MeSH ID:: D005600

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.597.606.360.455.500

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.260.830.300|C16.320.180.830.300|C16.320.322.500.500|C16.320.400.525.500

Synonym(s)

Fragile X Syndrome

Escalante syndrome

FRAGILE X SYNDROME

FRAXA - Fragile X syndrome

FXS

Fragile X syndrome

Marker X syndrome

Martin-Bell syndrome

Martin-Bell syndrome (MBS)

10.

Martin-Bell-Renpenning syndrome

11.

Renpenning syndrome 2

12.

X-linked mental deficiency-megalotestes syndrome

13.

X-linked mental retardation with fragile X syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Arthrotec	FAERS: 3		US FAERS
2	Tenofovir	FAERS: 2		US FAERS
3	Deferasirox	FAERS: 1		US FAERS
4	Diclofenac	FAERS: 1		US FAERS
5	Dimethyl Fumarate	FAERS: 1		US FAERS
6	Methadone	FAERS: 1		US FAERS
7	Methadone	FAERS: 1		US FAERS
8	Valproic Acid	FAERS: 1		US FAERS
9	Aluminum		12379314	CTD
10	Minocycline		18835858	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Rett Syndrome	47.8%
2	Cri-du-Chat Syndrome	40.7%
3	Down Syndrome	40.7%
4	Trisomy 21	40.7%
5	Mucopolysaccharidosis II	36.7%
6	Beckwith-Wiedemann Syndrome	36.7%
7	Wolf-Hirschhorn Syndrome	36.7%
8	Prader-Willi Syndrome	36.6%
9	Aicardi's syndrome	35%
10	Smith-Magenis syndrome	34.6%
11	Menkes Kinky Hair Syndrome	34.4%
12	Williams Syndrome	34%
13	Rubinstein-Taybi Syndrome	33.8%
14	Holoprosencephaly	31.7%
15	CHARGE Syndrome	27.9%
16	Cockayne Syndrome	27.5%
17	Adrenoleukodystrophy	27.4%
18	Ichthyosis, X-Linked	26.9%
19	Muscular Dystrophy, Duchenne	26.3%
20	Cystic Fibrosis	26.2%
21	Nail-Patella Syndrome	25%
22	Alstrom Syndrome	24.8%
23	Myasthenic Syndromes, Congenital	24.6%
24	Neoplastic Syndromes, Hereditary	24.1%
25	Multiple Epiphyseal Dysplasia	23.4%
26	Osteochondrodysplasias	23.4%
27	Pelger-Huet Anomaly	23.4%
28	Werner Syndrome	23.4%
29	Kartagener Syndrome	22.9%
30	Marfan Syndrome	22.1%
31	Albinism	21.8%
32	Anemia, Sickle Cell	21.7%
33	Thalassemia	21.7%
34	Ectodermal Dysplasia	21.6%
35	Aplasia Cutis Congenita	21.6%
36	Tuberous Sclerosis	21.3%
37	Wiskott-Aldrich Syndrome	21.3%
38	Muscular Dystrophy	21.1%
39	Dwarfism	21.1%
40	Myotonic Dystrophy	20.9%
41	Osteogenesis Imperfecta	20.4%
42	Classical Lissencephalies and Subcortical Band Heterotopias	20.2%
43	Neuronal Ceroid-Lipofuscinoses	19.2%
44	Klinefelter Syndrome	18.5%
45	Autoimmune Lymphoproliferative Syndrome	18.4%
46	Hepatolenticular Degeneration	18.2%
47	Angioedemas, Hereditary	18.1%
48	Amyloid Neuropathies, Familial	17.8%
49	Kallmann Syndrome	17.4%
50	Fetal Diseases	17.3%
51	Refsum Disease	17.3%
52	Polycystic Kidney Diseases	17.3%
53	Dystonia Musculorum Deformans	17.1%
54	Chronic granulomatous disease	17%
55	Smith-Lemli-Opitz Syndrome	17%
56	Myotonia Congenita	16.6%
57	Lafora Disease	16.4%
58	Unverricht-Lundborg Syndrome	16.4%
59	Abnormalities, Drug-Induced	16.3%
60	Situs Inversus	16.3%
61	Familial Mediterranean Fever	16.2%
62	Turner Syndrome	16.1%
63	Retinal Dysplasia	16%
64	Sjogren-Larsson Syndrome	16%
65	Aniridia	15.9%
66	Primary Ciliary Dyskinesia	15.9%
67	Ataxia Telangiectasia	15.8%
68	Canavan Disease	15.8%
69	Alexander Disease	15.8%
70	Epidermolysis Bullosa	15.7%
71	Fragile X Syndrome	15.4%
72	Fabry Disease	15.2%
73	Deformity	15%
74	Mobius Syndrome	14.8%
75	Charcot-Marie-Tooth Disease	14.5%
76	Eye Abnormalities	14.5%
77	Cardiovascular Abnormalities	14.5%
78	Sickle Cell Trait	14.3%
79	Skin Abnormalities	14.2%
80	Lymphatic Abnormalities	14.2%
81	Congenital Microtia	14.2%
82	Congenital diaphragmatic hernia	14%
83	Amino Acid Metabolism, Inborn Errors	13.9%
84	Carbohydrate Metabolism, Inborn Errors	13.9%
85	Metal Metabolism, Inborn Errors	13.9%
86	Progeria	13.9%
87	Lysosomal Storage Diseases	13.9%
88	Cytochrome-c Oxidase Deficiency	13.9%
89	Peroxisomal Disorders	13.9%
90	Xeroderma	13.9%
91	Optic Atrophy, Hereditary, Leber	13.6%
92	Meconium Aspiration Syndrome	13.4%
93	Anencephaly	13.2%
94	Pseudoxanthoma Elasticum	13.2%
95	Huntington Disease	13.1%
96	Zellweger Syndrome	12.8%
97	Urogenital Abnormalities	12.7%
98	Dural Arteriovenous Fistula	12.6%
99	Welander Distal Myopathy	12.5%
100	Cutis Laxa	12.3%
101	Retinitis Pigmentosa	12.3%
102	Pigmentary retinopathy	12.3%
103	Porokeratosis	12.2%
104	Keratoderma, Palmoplantar	12.2%
105	Xeroderma Pigmentosum	12.2%
106	Galactosemias	12%
107	Urea Cycle Disorders, Inborn	12%
108	Tyrosinemias	12%
109	Duane Retraction Syndrome	12%
110	Acute Chest Syndrome	11.9%
111	Polycystic Kidney, Autosomal Dominant	11.4%
112	Brain Diseases, Metabolic, Inborn	11.4%
113	Glycogen storage disease type II	11.2%
114	Basal Cell Nevus Syndrome	11.2%
115	Porphyrias, Hepatic	11%
116	Maxillofacial Abnormalities	10.9%
117	Abdominal Cramps	10.9%
118	Amniotic Band Syndrome	10.9%
119	Asphyxia Neonatorum	10.9%
120	Infant, Premature, Diseases	10.9%
121	Infantile Colic	10.9%
122	Peutz-Jeghers Syndrome	10.9%
123	Dextrocardia	10.8%
124	Thrombasthenia	10.8%
125	Antithrombin III Deficiency	10.8%
126	Protein C Deficiency	10.8%
127	Afibrinogenemia	10.8%
128	Factor VII Deficiency	10.8%
129	Factor X Deficiency	10.8%
130	Factor XII Deficiency	10.8%
131	Hemophilia A	10.8%
132	Activated Protein C Resistance	10.8%
133	Factor II deficiency	10.8%
134	Factor VIII Deficiency	10.8%
135	Factor V deficiency	10.8%
136	Factor XI Deficiency	10.8%
137	Hypoprothrombinemias	10.8%
138	Hyperkeratosis, Epidermolytic	10.8%
139	Fanconi Anemia	10.8%
140	Anemia, Diamond-Blackfan	10.7%
141	Hyperphosphaturia	10.7%
142	Hydranencephaly	10.5%
143	Neural Tube Defects	10.5%
144	Tethered Cord Syndrome	10.5%
145	Iniencephaly	10.5%
146	Craniorachischisis	10.5%
147	Exencephaly	10.5%
148	Septo-Optic Dysplasia	10.5%
149	Cortical Dysplasia	10.5%
150	Malformations of Cortical Development	10.5%
151	Friedreich Ataxia	10.3%
152	Antley-Bixler Syndrome Phenotype	10.3%
153	Multiple Endocrine Neoplasia	10%
154	Congenital Hypothyroidism	9.9%
155	Dermatitis, Atopic	9.8%
156	Abnormalities, Radiation-Induced	9.8%
157	Homocystinuria	9.7%
158	Prune Belly Syndrome	9.7%
159	Twins, Conjoined	9.7%
160	Waardenburg Syndrome	9.7%
161	Leigh Disease	9.7%
162	Mucopolysaccharidosis III	9.6%
163	Anemia, Neonatal	9.4%
164	Persistent Fetal Circulation Syndrome	9.4%
165	Umbilical hernia	9.3%
166	Dandy-Walker Syndrome	9.3%
167	Alkaptonuria	9.2%
168	Glycogen Storage Disease	9.2%
169	Hypophosphatasia	9.2%
170	Propionic acidemia	9.2%
171	Dihydropyrimidine Dehydrogenase Deficiency	9.2%
172	Cystinosis	9.2%
173	Central Nervous System Cysts	9.1%
174	Scimitar Syndrome	9.1%
175	Behcet Syndrome	8.9%
176	Congenital nystagmus	8.8%
177	Gaucher Disease	8.6%
178	Toxoplasmosis, Congenital	8.5%
179	Anophthalmos	8.4%
180	Anus, Imperforate	8.4%
181	Microphthalmos	8.4%
182	Limb Deformities, Congenital	8.4%
183	Craniofacial Abnormalities	8.4%
184	Anorectal Malformations	8.4%
185	Bloom Syndrome	8.4%
186	Neonatal Abstinence Syndrome	8.4%
187	Fetal Growth Retardation	8.2%
188	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.2%
189	Fetal Hypoxia	8.2%
190	Fetal Alcohol Spectrum Disorders	8.2%
191	Familial Periodic Paralysis	8.2%
192	Syphilis, Congenital	8.1%
193	Microcephaly	8.1%
194	Macrocephaly	8.1%
195	Hypolipoproteinemias	8%
196	Papillon-Lefevre Disease	8%
197	Hyperlipidemia, Familial Combined	8%
198	Hyperlipoproteinemia Type III	8%
199	Craniosynostosis	7.8%
200	Syndactyly	7.8%
201	Brachycephaly	7.8%
202	Acrocephalosyndactylia	7.7%
203	Nephroblastoma	7.5%
204	Blepharophimosis	7.5%
205	Laryngostenosis	7.5%
206	Mouth Abnormalities	7.5%
207	Esophageal Atresia	7.4%
208	Intestinal Atresia	7.4%
209	Horseshoe Kidney	7.4%
210	Pectus excavatum	7.4%
211	Klippel-Feil Syndrome	7.4%
212	Gastroschisis	7.4%
213	Synostosis	7.4%
214	Hydrops Fetalis	7.3%
215	Acrodermatitis	7.3%
216	Lymphangiectasis, Intestinal	7.3%
217	Gianotti-Crosti Syndrome	7.3%
218	Tay-Sachs Disease	7.3%
219	Congenital Hyperinsulinism	7.3%
220	Chorioamnionitis	7.3%
221	Niemann-Pick Disease, Type C	7.2%
222	Lactose Intolerance	7.2%
223	Variegate Porphyria	7.2%
224	Acute intermittent porphyria	7.2%
225	Porphyria Cutanea Tarda	7.2%
226	Hyperhomocysteinemia	7.2%
227	Confusion	7.2%
228	Lethargy	7.2%
229	Memory Disorders	7.2%
230	Perceptual Disorders	7.2%
231	Psychomotor Disorders	7.2%
232	Anhedonia	7.2%
233	Disorientation	7.2%
234	Memory Loss	7.2%
235	Hemisensory Neglect	7.2%
236	Noonan Syndrome	7.2%
237	Renal Aminoacidurias	7.1%
238	Fanconi Syndrome	7.1%
239	Pseudohypoaldosteronism	7.1%
240	Liddle Syndrome	7.1%
241	Hyperlipoproteinemia Type IV	7.1%
242	Hyperlipoproteinemia Type V	7.1%
243	POEMS Syndrome	7%
244	Porencephaly	7%
245	Adenomatous Polyposis Coli	6.9%
246	Glycogen Storage Disease Type I	6.9%
247	Glycogen Storage Disease Type V	6.9%
248	Meningomyelocele	6.7%
249	Spina Bifida	6.7%
250	Arthrogryposis	6.7%
251	Choanal Atresia	6.7%
252	Tracheobronchomegaly	6.7%
253	Laryngocele	6.7%
254	Choledochal Cyst	6.6%
255	Hermaphroditism	6.6%
256	Disorders of Sex Development	6.6%
257	Cleft Palate	6.6%
258	Cryptorchidism	6.6%
259	Hypospadias	6.6%
260	Asterixis	6.6%
261	Ballismus	6.6%
262	Gout	6.5%
263	Multiple Endocrine Neoplasia Type 1	6.5%
264	Pseudohypoparathyroidism	6.5%
265	Renal tubular acidosis	6.4%
266	Consciousness Disorders	6.4%
267	Depressed Level of Consciousness	6.4%
268	Catatonia	6.4%
269	Decerebrate State	6.3%
270	Hemiparesis	6.3%
271	Meningism	6.3%
272	Paresis	6.3%
273	Seizures	6.3%
274	Sensation Disorders	6.3%
275	Complex partial seizures	6.3%
276	Monoparesis	6.3%
277	Neurogenic Inflammation	6.3%
278	Gait Disorders, Neurologic	6.3%
279	Neuromuscular Manifestations	6.3%
280	Jaw Abnormalities	6.3%
281	Laryngomalacia	6%
282	Hypoalphalipoproteinemias	6%
283	Pectus carinatum	6%
284	Bladder Exstrophy	5.9%
285	Epispadias	5.9%
286	Hypokalemic periodic paralysis	5.9%
287	Ophthalmia Neonatorum	5.9%
288	Meningocele	5.9%
289	Multicystic Dysplastic Kidney	5.9%
290	Encephalocele	5.9%
291	Akathisia	5.8%
292	Restlessness	5.8%
293	Psychomotor Agitation	5.8%
294	Poland Syndrome	5.8%
295	Pupil Disorders	5.7%
296	Paralysis, Obstetric	5.6%
297	Retinopathy of Prematurity	5.6%
298	Familial Hypophosphatemic Rickets	5.6%
299	Amelia	5.5%
300	Arachnodactyly	5.5%
301	Bronchopulmonary Dysplasia	5.5%
302	Ectopia Cordis	5.5%
303	Ectromelia	5.5%
304	Hemimelia	5.5%
305	Phocomelia	5.5%
306	Sirenomelia	5.5%
307	Polydactyly	5.5%
308	Brachydactyly	5.5%
309	Plagiocephaly	5.5%
310	Lower Extremity Deformities, Congenital	5.5%
311	Upper Extremity Deformities, Congenital	5.5%
312	Single umbilical artery	5.5%
313	Vertigo	5.5%
314	Denys-Drash Syndrome	5.5%
315	Leukomalacia, Periventricular	5.4%
316	Glycosuria, Renal	5.4%
317	Cystinuria	5.3%
318	MELAS Syndrome	5.3%
319	Genetic Diseases, Inborn	5%
320	Voice Disorders	5%
321	Voice Disturbance	5%
322	Respiratory Distress Syndrome, Newborn	5%
323	Aortic coarctation	4.9%
324	Cor Triatriatum	4.9%
325	Coronary Vessel Anomalies	4.9%
326	Dental Enamel Hypoplasia	4.9%
327	Patent ductus arteriosus	4.9%
328	Ebstein Anomaly	4.9%
329	Heart Septal Defects	4.9%
330	Hypodontia	4.9%
331	Macrostomia	4.9%
332	Microstomia	4.9%
333	Tetralogy of Fallot	4.9%
334	Transposition of Great Vessels	4.9%
335	Hypoplastic Left Heart Syndrome	4.9%
336	May-Thurner Syndrome	4.9%
337	Craniofacial Dysostosis	4.8%
338	Micrognathism	4.8%
339	Pierre Robin Syndrome	4.8%
340	Arthritis, Gouty	4.8%
341	Wolff-Parkinson-White Syndrome	4.8%
342	Dermal Sinus	4.8%
343	Language Disorders	4.8%
344	Spina Bifida Cystica	4.8%
345	Spina Bifida Occulta	4.8%
346	Lissencephaly	4.8%
347	Polymicrogyria	4.8%
348	Pachygyria	4.8%
349	Schizencephaly	4.8%
350	Periventricular Nodular Heterotopia	4.8%
351	Cranial nerve diseases	4.7%
352	Demyelinating Diseases	4.7%
353	Demyelination	4.7%
354	Neuromuscular Diseases	4.7%
355	Chronobiology Disorders	4.7%
356	Gait Apraxia	4.7%
357	Alice in Wonderland Syndrome	4.6%
358	Alexia	4.5%
359	Dyslexia	4.5%
360	Retrognathia	4.4%
361	Hyperandrogenism	4.4%
362	Reflex, Abnormal	4.4%
363	Hyporeflexia	4.4%
364	Hyperreflexia	4.4%
365	Long QT Syndrome	4.3%
366	Platybasia	4.3%
367	Tricuspid Atresia	4.3%
368	Arrhythmogenic Right Ventricular Dysplasia	4.3%
369	Gonadal Dysgenesis	4.3%
370	Bronchomalacia	4.3%
371	Adrenogenital Syndrome	4.3%
372	Tracheomalacia	4.3%
373	Ovotesticular Disorders of Sex Development	4.3%
374	Nesidioblastosis	4.3%
375	Gait Ataxia	4.3%
376	Ophthalmoplegic Migraine	4.3%
377	Motor Neuron Disease	4.3%
378	Stiff-Person Syndrome	4.2%
379	Agnosia	4.2%
380	Apraxias	4.2%
381	Hallucinations	4.2%
382	Visual Agnosia	4.2%
383	Anosognosia	4.2%
384	Wernicke-Korsakoff Syndrome	4.2%
385	Trauma, Nervous System	4.2%
386	Restless Legs Syndrome	4.1%
387	Prognathism	4.1%
388	Nervous System Neoplasms	4.1%
389	Neurotoxicity Syndromes	4.1%
390	Dyskinesia, Drug-Induced	4%
391	Kernicterus	4%
392	Multiple System Atrophy	4%
393	Polyradiculoneuropathy	3.9%
394	Polyradiculoneuritis	3.9%
395	Ocular Motility Disorders	3.8%
396	Cyclophoria	3.8%
397	Amnesia	3.8%
398	Delirium	3.8%
399	Dissociative Amnesia	3.8%
400	Global Amnesia	3.8%
401	Subacute Combined Degeneration	3.8%
402	Ophthalmoplegia	3.6%
403	External Ophthalmoplegia	3.6%
404	Sleep Wake Disorders	3.6%
405	Chorea	3.6%
406	Aortopulmonary Septal Defect	3.6%
407	Double Outlet Right Ventricle	3.6%
408	Endocardial Cushion Defects	3.6%
409	Myocardial bridging	3.6%
410	Aorticopulmonary Septal Defect	3.6%
411	Auditory Perceptual Disorders	3.5%
412	Anosmia	3.5%
413	Ataxia	3.5%
414	Athetosis	3.5%
415	Catalepsy	3.5%
416	Dystonia	3.5%
417	Hemiplegia	3.5%
418	Locked-In Syndrome	3.5%
419	Muscle Hypertonia	3.5%
420	Muscle hypotonia	3.5%
421	Myoclonus	3.5%
422	Myotonia	3.5%
423	Paraplegia	3.5%
424	Pseudobulbar Palsy	3.5%
425	Quadriplegia	3.5%
426	Spasm	3.5%
427	Spastic Paraplegia	3.5%
428	Status Epilepticus	3.5%
429	Taste Disorders	3.5%
430	Tremor	3.5%
431	Monoplegia	3.5%
432	Hypokinesia	3.5%
433	Paraparesis	3.5%
434	Bradykinesia	3.5%
435	Waxy flexibility	3.5%
436	Action Tremor	3.5%
437	Resting Tremor	3.5%
438	Dysosmia	3.5%
439	Quadriparesis	3.5%
440	Olfaction Disorders	3.5%
441	Myokymia	3.5%
442	Somatosensory Disorders	3.5%
443	Hyperkinesia	3.5%
444	Intention tremor	3.5%
445	Persistent Vegetative State	3.4%
446	Phantom pain	3.4%
447	Phantom Limb Pain	3.4%
448	Progressive supranuclear palsy	3.4%
449	Vocal Cord Paralysis	3.3%
450	Opsoclonus-Myoclonus Syndrome	3.3%
451	Encephalomyelitis	3.3%
452	Prion Diseases	3.3%
453	Autonomic Dysreflexia	3.3%
454	Complex Regional Pain Syndromes	3.3%
455	Amyotrophic Lateral Sclerosis	3.3%
456	Horner Syndrome	3.3%
457	Hyaline Membrane Disease	3.2%
458	Cerebrospinal Fluid Otorrhea	3.2%
459	Cerebrospinal Fluid Rhinorrhea	3.2%
460	Mandibulofacial Dysostosis	3.2%
461	Romano-Ward Syndrome	3.2%
462	Agraphia	3.2%
463	Anomia	3.2%
464	Cluttering	3.2%
465	Language Development Disorders	3.2%
466	Speech Disorders	3.2%
467	Syncope	3.2%
468	Stupor	3.2%
469	Dysgraphia	3.2%
470	Presyncope	3.2%
471	Dyslalia	3.2%
472	Brain Death	3.1%
473	Coma, Post-Head Injury	3.1%
474	Vision Disorders	3.1%
475	Metamorphopsia	3.1%
476	Visual Impairment	3.1%
477	Anisocoria	3.1%
478	Facial paralysis	3.1%
479	Muscle Cramp	3.1%
480	Tonic Pupil	3.1%
481	Facial Paresis	3.1%
482	Dysacusis	3.1%
483	Amnesia, Transient Global	3.1%
484	Spinal Muscular Atrophy	3.1%
485	Progressive Muscular Atrophy	3.1%
486	Muscular Atrophy	3%
487	Respiratory Paralysis	3%
488	Tetany	3%
489	Truncus Arteriosus, Persistent	3%
490	Goldenhar Syndrome	3%
491	Alcohol Withdrawal Seizures	2.9%
492	Spinal Cord Injuries	2.9%
493	Peripheral Nerve Injuries	2.9%
494	Meningoencephalitis	2.9%
495	Myasthenia Gravis	2.9%
496	Parkinson Disease	2.8%
497	Lambert-Eaton Myasthenic Syndrome	2.8%
498	Dyscalculia	2.8%
499	Gerstmann Syndrome	2.8%
500	Prosopagnosia	2.8%
501	Apraxia, Ideomotor	2.8%
502	Charles Bonnet Syndrome	2.8%
503	Alien Hand Syndrome	2.8%
504	Marchiafava-Bignami Disease	2.8%
505	Lewy Body Disease	2.8%
506	Guillain-Barre Syndrome	2.8%
507	Muscle Weakness	2.8%
508	Aphonia	2.7%
509	Pneumocephalus	2.7%
510	Poliomyelitis	2.7%
511	Dysphonia	2.7%
512	Talipes	2.7%
513	Arteriovenous fistula	2.6%
514	Chronic Fatigue Syndrome	2.6%
515	Myelitis, Transverse	2.6%
516	Sleep Disorders, Circadian Rhythm	2.6%
517	Botulism	2.6%
518	Amblyopia	2.5%
519	Retrograde amnesia	2.5%
520	Amnesia, Anterograde	2.5%
521	Neuroleptic Malignant Syndrome	2.5%
522	Myelinolysis, Central Pontine	2.5%
523	Brain Diseases	2.5%
524	Dysautonomia	2.5%
525	Meningitis	2.5%
526	Movement Disorders	2.5%
527	Pachymeningitis	2.5%
528	Spinal Cord Diseases	2.5%
529	Vagus Nerve Disorder	2.5%
530	Glossopharyngeal Neuralgia	2.5%
531	Abducens Nerve Diseases	2.5%
532	Heavy Metal Poisoning, Nervous System	2.5%
533	Neuromuscular Junction Diseases	2.5%
534	Tauopathies	2.5%
535	Trochlear Nerve Diseases	2.5%
536	Peripheral Nervous System Diseases	2.5%
537	Leukoencephalitis, Acute Hemorrhagic	2.4%
538	Cerebellar Ataxia	2.4%
539	Torticollis	2.4%
540	Congenital clubfoot	2.4%
541	Vertical Talus	2.4%
542	Aphasia	2.4%
543	Articulation Disorders	2.4%
544	Echolalia	2.4%
545	Stuttering	2.4%
546	Dysphasia	2.4%
547	Neuromyelitis Optica	2.4%
548	Epidural Abscess	2.3%
549	Olfactory Nerve Injuries	2.3%
550	Striatonigral Degeneration	2.3%
551	Myelitis	2.3%
552	Progressive bulbar palsy	2.3%
553	Bulbar palsy	2.3%
554	Akathisia, Drug-Induced	2.3%
555	Miller Fisher Syndrome	2.3%
556	MPTP Poisoning	2.3%
557	Hoarseness	2.2%
558	Causalgia	2.2%
559	Tardive Dyskinesia	2.2%
560	Central Nervous System Infection	2.2%
561	Myopathy	2.2%
562	Optic Neuropathy	2.2%
563	Encephalomyelitis, Acute Disseminated	2.2%
564	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.2%
565	Facial Nerve Diseases	2.1%
566	Craniocerebral Trauma	2.1%
567	Parasomnia	2.1%
568	Dyssomnias	2.1%
569	Mutism	2.1%
570	Selective Mutism	2.1%
571	Facial Nerve Injuries	2.1%
572	Vestibulocochlear Nerve Diseases	2.1%
573	Central Nervous System Neoplasms	2.1%
574	Shy-Drager Syndrome	2.1%
575	Sweating, Gustatory	2.1%
576	Auriculotemporal Syndrome	2.1%
577	Dysgeusia	2.1%
578	Formication	2.1%
579	Hyperalgesia	2.1%
580	Hyperesthesia	2.1%
581	Hypesthesia	2.1%
582	Numbness	2.1%
583	Paresthesia	2.1%
584	Paraparesis, Spastic	2.1%
585	Trismus	2.1%
586	Epilepsia Partialis Continua	2.1%
587	Hypogeusia	2.1%
588	Brown-Sequard Syndrome	2.1%
589	Lockjaw	2.1%
590	Allodynia	2.1%
591	Ageusia	2.1%
592	Leukoencephalopathy, Progressive Multifocal	2.1%
593	Brain Injuries	2%
594	Brain Neoplasms	2%
595	Multiple Sclerosis	2%
596	Spinal Cord Neoplasms	2%
597	Dysarthria	2%
598	Vasculitis, Central Nervous System	2%
599	Jet Lag Syndrome	2%
600	Myasthenia Gravis, Autoimmune, Experimental	1.9%
601	Paraneoplastic Encephalomyelitis	1.9%
602	Uveomeningoencephalitic Syndrome	1.8%
603	Reflex Sympathetic Dystrophy	1.8%
604	Subdural Effusion	1.8%
605	Parkinsonian Disorders	1.8%
606	Nocturnal Myoclonus Syndrome	1.8%
607	Sturge-Weber Syndrome	1.8%
608	Alcohol-Induced Disorders, Nervous System	1.8%
609	Diplopia	1.8%
610	Muscle Rigidity	1.8%
611	Muscle Spasticity	1.8%
612	Scotoma	1.8%
613	Photophobia	1.8%
614	Cogwheel Rigidity	1.8%
615	Hemifacial Spasm	1.8%
616	Amaurosis	1.8%
617	Blindness	1.8%
618	Nuchal Rigidity	1.8%
619	Brain Abscess	1.8%
620	Hemianopsia	1.8%
621	Hyperacusis	1.8%
622	Tinnitus	1.8%
623	Phonophobia	1.8%
624	Hearing Loss	1.8%
625	Sarcopenia	1.8%
626	Limbic Encephalitis	1.8%
627	Alexia, Pure	1.8%
628	Lupus Vasculitis, Central Nervous System	1.7%
629	Scrapie	1.6%
630	Central Cord Syndrome	1.6%
631	Color blindness	1.6%
632	Presenile dementia	1.6%
633	Senile dementia	1.6%
634	Meningitis, Bacterial	1.6%
635	Meningitis, Fungal	1.6%
636	Acrodynia	1.6%
637	Epilepsy, Post-Traumatic	1.6%
638	Paraneoplastic Cerebellar Degeneration	1.4%
639	Neuritis, Autoimmune, Experimental	1.4%
640	Dementia, Vascular	1.4%
641	Brain Hemorrhage, Traumatic	1.4%
642	Meige Syndrome	1.4%
643	Brachial Plexus Neuritis	1.4%
644	Neuralgic Amyotrophy	1.4%
645	Cerebral Ventriculitis	1.4%
646	Akinetic Mutism	1.3%
647	Anoxic Encephalopathy	1.3%
648	Arachnoiditis	1.3%
649	Basal Ganglia Diseases	1.3%
650	Brain Damage, Chronic	1.3%
651	Cerebellar Diseases	1.3%
652	Encephalitis	1.3%
653	Encephalomalacia	1.3%
654	Epilepsy	1.3%
655	Hydrocephalus	1.3%
656	Congenital Hydrocephalus	1.3%
657	Hypothalamic Diseases	1.3%
658	Aseptic Meningitis	1.3%
659	Neuritis	1.3%
660	Polyneuritis	1.3%
661	Radiculitis	1.3%
662	Syringomyelia	1.3%
663	Thalamic Diseases	1.3%
664	Intracranial Hypertension	1.3%
665	Polyneuropathy	1.3%
666	Mononeuritis	1.3%
667	Aura	1.3%
668	Leukoencephalopathy	1.3%
669	Essential Tremor	1.3%
670	Neuroaxonal Dystrophies	1.3%
671	Familial Tremor	1.3%
672	Headache Disorders	1.3%
673	Mononeuropathies	1.3%
674	Intracranial Hypotension	1.3%
675	Brachial Plexus Neuropathies	1.3%
676	Radiculopathy	1.3%
677	Mononeuropathy Multiplex	1.3%
678	Nerve Root Compression	1.3%
679	Brain Edema	1.3%
680	Brain Hypoxia	1.3%
681	Aqueductal Stenosis	1.3%
682	Pneumorrhachis	1.3%
683	Writer's Cramp	1.3%
684	Carotid Artery Injuries	1.3%
685	Cerebellar Neoplasms	1.2%
686	Creutzfeldt-Jakob disease	1.2%
687	Basal Ganglia Cerebrovascular Disease	1.2%
688	Brain Injuries, Diffuse	1.2%
689	Traumatic Brain Injury	1.2%
690	Amaurosis Fugax	1.2%
691	Blindness, Cortical	1.2%
692	Supratentorial Neoplasms	1.2%
693	Multiple Sclerosis, Chronic Progressive	1.2%
694	Multiple Sclerosis, Relapsing-Remitting	1.2%
695	Deafness	1.2%
696	Hearing Loss, Sudden	1.2%
697	Hearing Loss, Bilateral	1.2%
698	Hearing Loss, High-Frequency	1.2%
699	Hearing Loss, Mixed Conductive-Sensorineural	1.2%
700	Hearing Loss, Unilateral	1.2%
701	Complete Hearing Loss	1.2%
702	Deaf Mutism	1.2%
703	Optic Nerve Glioma	1.2%
704	Brain Diseases, Metabolic	1.2%
705	Cerebrovascular Disorders	1.2%
706	Myositis	1.2%
707	Optic Atrophy	1.2%
708	Optic Neuritis	1.2%
709	Papilledema	1.2%
710	Strabismus	1.2%
711	Tolosa-Hunt Syndrome	1.2%
712	Cerebrovascular Insufficiency	1.2%
713	Isaacs syndrome	1.2%
714	Arsenic Poisoning	1.2%
715	Dementia	1.2%
716	Myotonic Disorders	1.2%
717	Central Nervous System Fungal Infections	1.2%
718	Conus Medullaris Syndrome	1.2%
719	Spinal Cord Vascular Diseases	1.2%
720	Diabetic Neuropathies	1.2%
721	Facial Injuries	1.2%
722	Facial Neuralgia	1.2%
723	Diabetic Amyotrophy	1.2%
724	Diabetic Autonomic Neuropathy	1.2%
725	Sleep Talking	1.2%
726	Manganese Poisoning	1.2%
727	Sleep Disorders, Intrinsic	1.2%
728	Orthostatic intolerance	1.2%
729	Acoustic Neuroma	1.2%
730	Meningeal Neoplasms	1.2%
731	Neuralgia	1.2%
732	Mercury Poisoning, Nervous System	1.2%
733	Lead Poisoning, Nervous System	1.2%
734	Vestibular Neuronitis	1.2%
735	Neuropathic pain	1.2%
736	Tarsal Tunnel Syndrome	1.1%
737	Cauda Equina Syndrome	1.1%
738	Posterior Leukoencephalopathy Syndrome	1.1%
739	Posterior reversible encephalopathy syndrome	1.1%
740	Vertebral Artery Dissection	1.1%
741	Tuberculosis, Meningeal	1.1%
742	Toxoplasmosis, Cerebral	1.1%
743	Kearns-Sayre syndrome	1.1%
744	Hand-Arm Vibration Syndrome	1.1%
745	Fibromyalgia	1%
746	Optic Neuropathy, Ischemic	1%
747	Anterior Ischemic Optic Neuropathy	1%
748	Central Nervous System Bacterial Infections	1%
749	Medial Tibial Stress Syndrome	1%
750	Facial Hemiatrophy	1%
751	Melkersson-Rosenthal Syndrome	1%
752	Mitochondrial Myopathies	1%
753	Brain Concussion	1%
754	Eosinophilia-Myalgia Syndrome	1%
755	Sleep Bruxism	1%
756	Carpal Tunnel Syndrome	1%
757	Vascular Headaches	1%
758	neurofibroma	1%
759	Hypoxia-Ischemia, Brain	1%
760	Sciatica	1%
761	Mitochondrial Encephalomyopathies	1%
762	Giant Cell Arteritis	0.9%
763	Temporal Arteritis	0.9%
764	Myoclonic Epilepsy	0.9%
765	Epilepsy, Temporal Lobe	0.9%
766	Epilepsy, Rolandic	0.9%
767	Benign Rolandic Epilepsy	0.9%
768	Bell Palsy	0.9%
769	Herpes Zoster Oticus	0.9%
770	Sleep Deprivation	0.9%
771	Meningitis, Cryptococcal	0.9%
772	Meningitis, Listeria	0.9%
773	Meningitis, Haemophilus	0.9%
774	Meningitis, Pneumococcal	0.9%
775	Frontotemporal dementia	0.9%
776	Pituitary Adenoma	0.9%
777	Pituitary Neoplasms	0.9%
778	Myalgia	0.8%
779	Cerebral Palsy	0.8%
780	Epilepsies, Partial	0.8%
781	Epilepsy, Generalized	0.8%
782	Pseudotumor Cerebri	0.8%
783	Sciatic Neuropathy	0.8%
784	Hypertensive Encephalopathy	0.8%
785	Ulnar Neuropathies	0.8%
786	Lesion of Sciatic Nerve	0.8%
787	Simple Partial Seizures	0.8%
788	Epilepsy, Reflex	0.8%
789	Ulnar Neuritis	0.8%
790	Radial nerve compression	0.8%
791	Radial Tunnel Syndrome	0.8%
792	Peroneal Neuropathies	0.8%
793	Radial Neuropathy	0.8%
794	Median Neuropathy	0.8%
795	Sciatic Nerve Palsy	0.8%
796	Femoral Neuropathy	0.8%
797	Tibial Neuropathy	0.8%
798	Ulnar Nerve Palsy	0.8%
799	Postural Orthostatic Tachycardia Syndrome	0.8%
800	Radial nerve palsy	0.8%
801	Headache Disorders, Primary	0.8%
802	Headache Disorders, Secondary	0.8%
803	Medication overuse headache	0.8%
804	Cubital Tunnel Syndrome	0.8%
805	Subarachnoid Hemorrhage, Traumatic	0.8%
806	Carotid Artery, Internal, Dissection	0.8%
807	Diffuse Axonal Injury	0.8%
808	Brain Stem Neoplasms	0.8%
809	Basal Ganglia Hemorrhage	0.8%
810	Subacute Sclerosing Panencephalitis	0.7%
811	Alcohol Withdrawal Delirium	0.7%
812	Pituitary Apoplexy	0.7%
813	Brain Contusion	0.7%
814	Brain Infarction	0.7%
815	Pituitary Diseases	0.7%
816	Thoracic Outlet Syndrome	0.7%
817	Carotid Artery Diseases	0.7%
818	Brain Ischemia	0.7%
819	Esotropia	0.7%
820	Exotropia	0.7%
821	Hypotension, Orthostatic	0.7%
822	Sleep Apnea Syndromes	0.7%
823	Cerebrovascular accident	0.7%
824	Polymyositis	0.7%
825	Kluver-Bucy Syndrome	0.7%
826	Vasospasm, Intracranial	0.7%
827	Spinal Cord Ischemia	0.7%
828	Intracranial Arterial Diseases	0.7%
829	Post-Exercise Hypotension	0.7%
830	Disorders of Excessive Somnolence	0.7%
831	Sleep Initiation and Maintenance Disorders	0.7%
832	Night Terrors	0.7%
833	Somnambulism	0.7%
834	Trigeminal Nerve Disorder	0.7%
835	Transient Insomnia	0.7%
836	Sleep Paralysis	0.7%
837	Chronic Insomnia	0.7%
838	REM Sleep Behavior Disorder	0.7%
839	Hypersomnia	0.7%
840	Meningeal Carcinomatosis	0.7%
841	Lead Poisoning, Nervous System, Childhood	0.7%
842	Lead Poisoning, Nervous System, Adult	0.7%
843	Tuberculosis, Central Nervous System	0.7%
844	Juvenile Myoclonic Epilepsy	0.7%
845	Myoclonic Epilepsies, Progressive	0.7%
846	Hematoma, Subdural	0.7%
847	Hematoma, Epidural, Cranial	0.7%
848	Eye Injuries	0.6%
849	Putaminal Hemorrhage	0.6%
850	Orbital Myositis	0.6%
851	Reye Syndrome	0.6%
852	Neuroaspergillosis	0.6%
853	Pyomyositis	0.6%
854	Intracranial Embolism and Thrombosis	0.6%
855	Hepatic Encephalopathy	0.6%
856	Choroid Plexus Papilloma	0.6%
857	Infarction, Middle Cerebral Artery	0.6%
858	Infarction, Anterior Cerebral Artery	0.6%
859	Infarction, Posterior Cerebral Artery	0.6%
860	Moyamoya Disease	0.6%
861	Pseudorabies	0.6%
862	Neurofibrosarcoma	0.6%
863	Meningioma	0.5%
864	Neurosyphilis	0.5%
865	Polyradiculopathy	0.5%
866	Post-Traumatic Headache	0.5%
867	Tension Headache	0.5%
868	Epilepsy, Complex Partial	0.5%
869	Migraine Disorders	0.5%
870	Abdominal Migraine	0.5%
871	Status Migrainosus	0.5%
872	Cervicogenic Headache	0.5%
873	Cerebral Infarction	0.5%
874	Brain Stem Infarctions	0.5%
875	West Nile Fever	0.5%
876	Wernicke Encephalopathy	0.5%
877	AIDS Dementia Complex	0.5%
878	Lyme Neuroborreliosis	0.5%
879	Hematoma, Subdural, Intracranial	0.5%
880	Hematoma, Subdural, Chronic	0.5%
881	Hematoma, Subdural, Acute	0.5%
882	Empty Sella Syndrome	0.5%
883	Hyperpituitarism	0.5%
884	Hypopituitarism	0.5%
885	Hypophysitis	0.5%
886	Cerebral Arterial Diseases	0.5%
887	Vertebrobasilar Insufficiency	0.5%
888	Anterior Spinal Artery Syndrome	0.5%
889	Basilar Artery Stenosis	0.5%
890	Vertebral Artery Stenosis	0.5%
891	Sleep Apnea, Obstructive	0.5%
892	Sleep Apnea, Central	0.5%
893	Intracranial Hemorrhage, Hypertensive	0.5%
894	Transient Cerebral Ischemia	0.5%
895	Narcolepsy	0.5%
896	Trigeminal Neuralgia	0.5%
897	Kleine-Levin Syndrome	0.5%
898	Lateral Medullary Syndrome	0.4%
899	Eye Burns	0.4%
900	Malaria, Cerebral	0.4%
901	Carotid Stenosis	0.4%
902	Intracranial Aneurysm	0.4%
903	Neurocysticercosis	0.4%
904	Waterhouse-Friderichsen Syndrome	0.4%
905	Intracranial Arteriosclerosis	0.4%
906	Cerebral Atherosclerosis	0.4%
907	Subarachnoid Hemorrhage	0.4%
908	Cerebral Arteriosclerosis	0.4%
909	Cerebral Hemorrhage	0.4%
910	Cerebral Thrombosis	0.4%
911	Intracranial Embolism	0.4%
912	Intracranial Thrombosis	0.4%
913	Cluster Headache	0.4%
914	Migraine with Aura	0.4%
915	Familial Hemiplegic Migraine	0.4%
916	Chronic Paroxysmal Hemicrania	0.4%
917	SUNCT Syndrome	0.4%
918	Paroxysmal Hemicrania	0.4%
919	Dermatomyositis	0.4%
920	Corneal Scar	0.4%
921	Carotid Artery Thrombosis	0.4%
922	Hyperprolactinemia	0.3%
923	Subclavian Steal Syndrome	0.3%
924	Pick Disease of the Brain	0.3%
925	Cataplexy	0.3%
926	Acromegaly	0.3%
927	Cerebral Amyloid Angiopathy	0.3%
928	Sinus Thrombosis, Intracranial	0.3%
929	Corneal Perforation	0.3%
930	Cavernous Sinus Thrombosis	0.2%
931	Sagittal Sinus Thrombosis	0.2%
932	Prolactinoma	0.2%
933	Growth Hormone-Secreting Pituitary Adenoma	0.2%
934	Nelson Syndrome	0.2%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120140