MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Rickets

(UMLS:C0035579)

Definition:: Disorders caused by interruption of BONE MINERALIZATION manifesting as OSTEOMALACIA in adults and characteristic deformities in infancy and childhood due to disturbances in normal BONE FORMATION. The mineralization process may be interrupted by disruption of VITAMIN D; PHOSPHORUS; or CALCIUM homeostasis, resulting from dietary deficiencies, or acquired, or inherited metabolic, or hormonal disturbances.
UMLS ID:: C0035579
MeSH ID:: D012279

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.198.816

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.104.816|C18.452.174.845|C18.654.521.500.133.770.734

Synonym(s)

Rickets

Hypovitaminosis D

OSTEOMALACIA, INFANTILE

RICKETT

Rachitis

Rickets, NOS

Vitamin D deficiency disease

Weak and soft bones

hypovitaminosis d

10.

infantile; osteomalacia

11.

osteomalacia; infantile

12.

rachitis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Sertraline	FAERS: 8		US FAERS
2	Acitretin	FAERS: 3		US FAERS
3	Carbamazepine	FAERS: 3		US FAERS
4	Prednisolone	FAERS: 3		US FAERS
5	Isotretinoin	FAERS: 2		US FAERS
6	Lansoprazole	FAERS: 2		US FAERS
7	Tenofovir	FAERS: 2		OFFSIDES US FAERS
8	4-phenylbutyric acid	FAERS: 1		US FAERS
9	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	FAERS: 1		US FAERS
10	Bosentan	FAERS: 1		US FAERS
11	Deferasirox	FAERS: 1		US FAERS
12	Etidronic Acid	FAERS: 1		US FAERS
13	Fluticasone-Salmeterol Drug Combination	FAERS: 1		US FAERS
14	Levofloxacin	FAERS: 1		US FAERS
15	Octreotide	FAERS: 1		US FAERS
16	Omeprazole	FAERS: 1		US FAERS
17	Phenobarbital	FAERS: 1		US FAERS
18	Pregabalin	FAERS: 1		US FAERS
19	Simvastatin	FAERS: 1		US FAERS
20	Tacrolimus	FAERS: 1		US FAERS
21	Tenofovir	FAERS: 1		OFFSIDES US FAERS
22	Teriparatide	FAERS: 1		US FAERS
23	nitisinone	FAERS: 1		US FAERS
24	Calcitriol		View details 2856045 15818308 16494812 17451081 20578617	CTD
25	Calcium Compounds		17451081 25483621	CTD
26	Clobazam			OFFSIDES
27	Etoposide			OFFSIDES
28	Ifosfamide		View details 1574040 2029077 2166154 2386379 2504390 2567921 7761316 8183542 8508598 8774570 8950339 11219485 12806945	CTD OFFSIDES SIDER
29	Lamotrigine			OFFSIDES
30	Mesna			OFFSIDES
31	Phosphates			OFFSIDES
32	Topiramate			SIDER
33	Vitamin D		View details 465192 1338926 6300811 21048240 25483621	CTD
34	alfacalcidol		View details 1338926 3037475 6285251 17451081	CTD
35	calcium lactate		3037475	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Pseudohypoparathyroidism	48.1%
2	Osteoporosis	38.7%
3	Bone Demineralization, Pathologic	38.7%
4	Post-Traumatic Osteoporosis	38.7%
5	Hypercalcemia	37.7%
6	Hypocalcemia	37.7%
7	Milk-Alkali Syndrome	37.7%
8	Wasting Syndrome	36.6%
9	Osteoporosis, Postmenopausal	28.4%
10	Calcinosis	27.8%
11	Acid-Base Imbalance	26.9%
12	Iron Metabolism Disorders	26.9%
13	Phosphorus Metabolism Disorders	26.9%
14	Water-Electrolyte Imbalance	26.9%
15	Lipid Metabolism Disorders	26.9%
16	Mitochondrial Diseases	26.9%
17	Glucose Metabolism Disorders	26.9%
18	Hyperhomocysteinemia	26.7%
19	Lipodystrophy	24.8%
20	Leigh Disease	23.7%
21	Brain Diseases, Metabolic	22.4%
22	Brain Diseases, Metabolic, Inborn	21.6%
23	Carbamoyl-Phosphate Synthase I Deficiency Disease	21.6%
24	Calciphylaxis	20.5%
25	Vascular calcification	20.5%
26	Hyperlipoproteinemia Type IV	19.1%
27	Hyperlipoproteinemia Type V	19.1%
28	Smith-Lemli-Opitz Syndrome	18.8%
29	Galactosemias	18.7%
30	Urea Cycle Disorders, Inborn	18.7%
31	Tyrosinemias	18.7%
32	Lactose Intolerance	18.6%
33	Ascorbic Acid Deficiency	18.4%
34	Vitamin A Deficiency	18.4%
35	Vitamin E Deficiency	18.4%
36	Mitochondrial Encephalomyopathies	18%
37	Hypolipoproteinemias	17.9%
38	Gaucher Disease	17.6%
39	Acidosis	17.3%
40	Alkalosis	17.3%
41	Amyloidosis	17.3%
42	Hyperglycemia	17.3%
43	Hyperinsulinism	17.3%
44	Hyperkalemia	17.3%
45	Hypernatremia	17.3%
46	Hypoglycemia	17.3%
47	Hypokalemia	17.3%
48	Hyponatremia	17.3%
49	Xanthomatosis	17.3%
50	Hypophosphatemia	17.3%
51	Metabolic acidosis	17.3%
52	Dyslipidemias	17.3%
53	Iron Overload	17.3%
54	Xanthoma	17.3%
55	Hyperphosphaturia	17%
56	Glycogen storage disease type II	16.8%
57	Familial Hypophosphatemic Rickets	16.7%
58	Child Nutrition Disorders	16.5%
59	Hypervitaminosis A	16.5%
60	Infant Nutrition Disorders	16.5%
61	Diabetic Ketoacidosis	16.3%
62	Hyperlipidemia, Familial Combined	16.3%
63	Magnesium Deficiency	16.2%
64	Potassium Deficiency	16.2%
65	Protein Deficiency	16.2%
66	Homocystinuria	16.1%
67	Congenital Hyperinsulinism	16.1%
68	Starvation	15.7%
69	Refeeding Syndrome	15.7%
70	Tay-Sachs Disease	15.6%
71	Hyperlipoproteinemia Type III	15.4%
72	Mitochondrial Myopathies	15.4%
73	Wernicke Encephalopathy	15.3%
74	Niemann-Pick Disease, Type C	15.1%
75	Amyloid Neuropathies, Familial	15%
76	HIV Wasting Syndrome	14.9%
77	Diabetes Mellitus	14.9%
78	Calcium Metabolism Disorders	14.9%
79	Nephrocalcinosis	14.6%
80	Tetany	14.6%
81	Dehydration	14.6%
82	Lipomatosis	14.6%
83	Water Intoxication	14.6%
84	Werner Syndrome	14.6%
85	Hypoalphalipoproteinemias	14.6%
86	Achlorhydria	14.4%
87	Amino Acid Metabolism, Inborn Errors	14.4%
88	Bloom Syndrome	14.4%
89	Carbohydrate Metabolism, Inborn Errors	14.4%
90	Metal Metabolism, Inborn Errors	14.4%
91	Progeria	14.4%
92	Lysosomal Storage Diseases	14.4%
93	Cytochrome-c Oxidase Deficiency	14.4%
94	Peroxisomal Disorders	14.4%
95	Adrenoleukodystrophy	14.4%
96	Celiac Disease	14.4%
97	Sprue, Tropical	14.4%
98	Steatorrhea	14.4%
99	Sprue	14.4%
100	Fabry Disease	14.4%
101	MELAS Syndrome	14.2%
102	Renal tubular acidosis	13.9%
103	Nutrition Disorders	13.7%
104	Rickets	13.6%
105	Zellweger Syndrome	13.5%
106	Osteoarthropathy, Secondary Hypertrophic	13.5%
107	Menkes Kinky Hair Syndrome	13.4%
108	Vitamin K Deficiency	13.2%
109	Folic Acid Deficiency	13%
110	Pellagra	13%
111	Thiamine Deficiency	13%
112	Vitamin B 12 Deficiency	13%
113	Vitamin B 6 Deficiency	13%
114	Pyridoxine Deficiency	13%
115	Nesidioblastosis	12.9%
116	Neuronal Ceroid-Lipofuscinoses	12.7%
117	Hepatolenticular Degeneration	12.6%
118	Acidosis, Lactic	12.6%
119	Hemosiderosis	12.6%
120	Ketosis	12.6%
121	Ketonuria	12.6%
122	Ketoacidosis	12.6%
123	Ketonemia	12.6%
124	HIV-Associated Lipodystrophy Syndrome	12.5%
125	Osteopenia	12.5%
126	Refsum Disease	12.5%
127	Myelinolysis, Central Pontine	12.5%
128	Glycosuria	12.3%
129	Reye Syndrome	12.3%
130	Hepatic Encephalopathy	12.3%
131	Gout	12.2%
132	Bone Diseases, Developmental	12%
133	Hyperostosis	12%
134	Osteitis	12%
135	Osteitis Deformans	12%
136	Osteochondrosis	12%
137	Spinal Diseases	12%
138	Cockayne Syndrome	11.6%
139	Osteochondritis	11.6%
140	Platybasia	11.5%
141	Gigantism	11.3%
142	Spinal Neoplasms	11.3%
143	Spondylitis	11.3%
144	Glycosuria, Renal	11.3%
145	Mucopolysaccharidosis III	11.3%
146	Antley-Bixler Syndrome Phenotype	11.1%
147	Porphyrias, Hepatic	10.9%
148	Necrobiosis Lipoidica Diabeticorum	10.8%
149	Fanconi Anemia	10.7%
150	Marasmus	10.6%
151	Acidosis, Respiratory	10.5%
152	Adiposis Dolorosa	10.5%
153	Alkalosis, Respiratory	10.5%
154	Alkaptonuria	10.5%
155	Glycogen Storage Disease	10.5%
156	Hypophosphatasia	10.5%
157	Insulin Resistance	10.5%
158	Propionic acidemia	10.5%
159	Dihydropyrimidine Dehydrogenase Deficiency	10.5%
160	Cystinosis	10.5%
161	Familial Periodic Paralysis	10.4%
162	Kearns-Sayre syndrome	10.4%
163	Bone Diseases, Endocrine	10.4%
164	Beriberi	10.3%
165	Hypercholesterolemia	10.3%
166	Hyperlipoproteinemias	10.3%
167	Hypertriglyceridemia	10.3%
168	CREST Syndrome	10.2%
169	Bone Diseases, Infectious	10.1%
170	Bone neoplasms	10.1%
171	Osteomalacia	10%
172	Bone Resorption	10%
173	Aseptic Necrosis of Bone	10%
174	Kwashiorkor	9.7%
175	Friedreich Ataxia	9.5%
176	Scurvy	9.3%
177	Arthritis, Gouty	9.3%
178	Gestational Diabetes	9.2%
179	Latent Autoimmune Diabetes in Adults	9.2%
180	Diabetes Mellitus, Experimental	9.1%
181	Pectus carinatum	9%
182	Cerebral Amyloid Angiopathy	8.9%
183	Sjogren-Larsson Syndrome	8.8%
184	Kernicterus	8.7%
185	Pectus excavatum	8.6%
186	Anemia, Pernicious	8.6%
187	Glycogen Storage Disease Type I	8.5%
188	Glycogen Storage Disease Type V	8.5%
189	Canavan Disease	8.5%
190	Alexander Disease	8.5%
191	Mucopolysaccharidosis II	8.5%
192	Discitis	8.4%
193	Hypokalemic periodic paralysis	8%
194	Malnutrition	8%
195	Ataxia Telangiectasia	8%
196	Primary amyloidosis	7.9%
197	Ainhum	7.9%
198	Dysostoses	7.9%
199	Spinal Stenosis	7.9%
200	Spondylosis	7.9%
201	Intervertebral Disc Degeneration	7.9%
202	Variegate Porphyria	7.9%
203	Acute intermittent porphyria	7.9%
204	Porphyria Cutanea Tarda	7.9%
205	Renal Aminoacidurias	7.8%
206	Fanconi Syndrome	7.8%
207	Pseudohypoaldosteronism	7.8%
208	Liddle Syndrome	7.8%
209	Optic Atrophy, Hereditary, Leber	7.8%
210	Congenital Hypothyroidism	7.8%
211	Arthrogryposis	7.6%
212	Renal Osteodystrophy	7.3%
213	Renal rickets	7.3%
214	Tuberculosis, Spinal	7.3%
215	Xeroderma Pigmentosum	7.3%
216	Osteoarthritis, Spine	7.1%
217	Klippel-Feil Syndrome	7.1%
218	Synostosis	7.1%
219	Amyotrophic Lateral Sclerosis	7.1%
220	Fasciitis	6.9%
221	Foot Deformities	6.9%
222	Arthropathy	6.9%
223	Contracture	6.8%
224	Fasciitis, Plantar	6.8%
225	Multiple Epiphyseal Dysplasia	6.7%
226	Osteochondrodysplasias	6.7%
227	Osteomyelitis	6.6%
228	Periostitis	6.6%
229	Eosinophilic Granuloma	6.6%
230	Alveolar Bone Loss	6.6%
231	Femur Head Necrosis	6.6%
232	Osteolysis	6.6%
233	Frontotemporal dementia	6.4%
234	Cystinuria	6.4%
235	Ankylosing spondylitis	6.2%
236	Craniofacial Dysostosis	6.1%
237	Obesity	6%
238	Chondrodysplasia Punctata	5.9%
239	Enchondromatosis	5.9%
240	Lordosis	5.9%
241	Osteosclerosis	5.9%
242	Spondylolysis	5.9%
243	kyphosis	5.9%
244	Kashin-Beck Disease	5.9%
245	Jaw Diseases	5.9%
246	Dwarfism	5.9%
247	Subacute Combined Degeneration	5.9%
248	Acrocephalosyndactylia	5.9%
249	Albinism	5.8%
250	Fibromyalgia	5.8%
251	Polymyalgia Rheumatica	5.8%
252	Cartilage Diseases	5.8%
253	Foot Diseases	5.8%
254	Myopathy	5.8%
255	Rheumatism	5.8%
256	Chondromalacia	5.8%
257	Metatarsalgia	5.7%
258	Spondylarthropathies	5.7%
259	Metabolic Diseases	5.7%
260	Craniosynostosis	5.6%
261	Syndactyly	5.6%
262	Brachycephaly	5.6%
263	Acromegaly	5.6%
264	Joint Tuberculosis	5.6%
265	Tuberculosis, Osteoarticular	5.6%
266	Bone Tuberculosis	5.6%
267	Arthritis, Psoriatic	5.4%
268	Deficiency Diseases	5.3%
269	Arthritis, Reactive	5%
270	Ischemic contracture	5%
271	Melorheostosis	4.9%
272	Osteopetrosis	4.9%
273	Spondylolisthesis	4.9%
274	Temporomandibular Joint Disorders	4.9%
275	Ichthyosis, X-Linked	4.9%
276	Rheumatic Fever	4.7%
277	Poland Syndrome	4.6%
278	Obesity, Abdominal	4.5%
279	Temporomandibular Joint Dysfunction Syndrome	4.4%
280	Hip Contracture	4.4%
281	Periarthritis	4.4%
282	Talipes	4.3%
283	Mandibulofacial Dysostosis	4.3%
284	Osteogenesis Imperfecta	4.3%
285	Goldenhar Syndrome	4.3%
286	Rheumatoid Arthritis	4.2%
287	Juvenile arthritis	4.2%
288	Mastoiditis	4.2%
289	Petrositis	4.2%
290	Arthritis	4%
291	Bursitis	4%
292	Joint Instability	4%
293	Myofascial Pain Syndromes	4%
294	Rhabdomyolysis	4%
295	Synovitis	4%
296	Joint laxity	4%
297	Polyarthritis	4%
298	Frozen shoulder	4%
299	Patellofemoral Pain Syndrome	4%
300	Pediatric Obesity	3.9%
301	Avitaminosis	3.9%
302	Rubinstein-Taybi Syndrome	3.9%
303	Osteoarthritis, Knee	3.8%
304	Basal Cell Nevus Syndrome	3.8%
305	Palatal Neoplasms	3.8%
306	Marfan Syndrome	3.7%
307	Prader-Willi Syndrome	3.6%
308	Compartment syndromes	3.4%
309	Maxillary Diseases	3.4%
310	Tendinitis	3.4%
311	Tendinopathy	3.4%
312	Hemarthrosis	3.3%
313	Myositis	3.3%
314	Tietze's Syndrome	3.3%
315	Limb Deformities, Congenital	3.3%
316	Isaacs syndrome	3.3%
317	Craniofacial Abnormalities	3.3%
318	Myotonic Disorders	3.3%
319	Congenital clubfoot	3.3%
320	Vertical Talus	3.3%
321	Rheumatoid Nodule	3.3%
322	Vitamin D Deficiency	3.3%
323	Jaw Abnormalities	3%
324	Medial Tibial Stress Syndrome	2.9%
325	Felty Syndrome	2.9%
326	Prognathism	2.9%
327	Muscle Cramp	2.8%
328	Eosinophilia-Myalgia Syndrome	2.8%
329	Gastroschisis	2.8%
330	Muscle Rigidity	2.8%
331	Muscle Spasticity	2.8%
332	Cogwheel Rigidity	2.8%
333	Nuchal Rigidity	2.8%
334	Nose Neoplasms	2.8%
335	Bunion	2.6%
336	Fibrodysplasia Ossificans Progressiva	2.6%
337	Myoglobinuria	2.6%
338	Myositis Ossificans	2.6%
339	Tenosynovitis	2.6%
340	Sacroiliitis	2.6%
341	Chronic Fatigue Syndrome	2.6%
342	Rheumatoid Vasculitis	2.5%
343	Nail-Patella Syndrome	2.5%
344	Giant Cell Epulis	2.5%
345	Muscle Weakness	2.5%
346	Musculoskeletal Pain	2.5%
347	Arthralgia	2.5%
348	Polyarthralgia	2.5%
349	Sicca Syndrome	2.3%
350	Sjogren's Syndrome	2.3%
351	Laryngomalacia	2.3%
352	Arthritis, Infectious	2.2%
353	Anterior Compartment Syndrome	2.2%
354	Enthesopathy	2.2%
355	Arthritis, Experimental	2.2%
356	Abdominal Compartment Syndrome	2.2%
357	Myalgia	2.2%
358	Amelia	2.2%
359	Arachnodactyly	2.2%
360	Ectromelia	2.2%
361	Hemimelia	2.2%
362	Phocomelia	2.2%
363	Sirenomelia	2.2%
364	Polymyositis	2.2%
365	Polydactyly	2.2%
366	Brachydactyly	2.2%
367	Plagiocephaly	2.2%
368	Lower Extremity Deformities, Congenital	2.2%
369	Upper Extremity Deformities, Congenital	2.2%
370	Micrognathism	2.1%
371	Pierre Robin Syndrome	2.1%
372	Myotonic Dystrophy	2.1%
373	Retrognathia	1.9%
374	Hip Dislocation	1.9%
375	Shoulder Dislocation	1.9%
376	Hip Dysplasia	1.9%
377	Muscular Dystrophy	1.9%
378	Orbital Myositis	1.9%
379	Dupuytren Contracture	1.9%
380	Pyomyositis	1.9%
381	Maxillofacial Abnormalities	1.7%
382	Myotonia Congenita	1.6%
383	Bronchomalacia	1.6%
384	Tracheomalacia	1.6%
385	Cleft Palate	1.6%
386	Microcephaly	1.6%
387	Macrocephaly	1.6%
388	Shoulder Pain	1.6%
389	Welander Distal Myopathy	1.4%
390	Noonan Syndrome	1.3%
391	Dermatomyositis	1.2%
392	Muscular Dystrophy, Duchenne	1.2%
393	Porencephaly	1.2%
394	Holoprosencephaly	1.2%
395	Radicular Cyst	0.9%

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