MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Thiamine Deficiency

(UMLS:C0039841)

Definition:: A nutritional condition produced by a deficiency of THIAMINE in the diet, characterized by anorexia, irritability, and weight loss. Later, patients experience weakness, peripheral neuropathy, headache, and tachycardia. In addition to being caused by a poor diet, thiamine deficiency in the United States most commonly occurs as a result of alcoholism, since ethanol interferes with thiamine absorption. In countries relying on polished rice as a dietary staple, BERIBERI prevalence is very high. (From Cecil Textbook of Medicine, 19th ed, p1171)
UMLS ID:: C0039841
MeSH ID:: D013832

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.654.521.500.133.699.827

Synonym(s)

Thiamine Deficiency

Aneurin deficiency

Low levels of vitamin B1

Reduced blood thiamine level

THIAMINE DEFICIENCY

Thiamin deficiency

Thiamin deficiency, NOS

Thiamine deficiency

Thiamine deficiency disease

10.

Thiamine deficiency, unspecified

11.

VITAMIN B1 DEFICIENCY

12.

Vitamin B1 deficiency

13.

Vitamin B1 deficiency, NOS

14.

aneurin; deficiency

15.

deficiencies thiamin

16.

deficiency thiamin

17.

deficiency thiamine

18.

deficiency vitamin b1

19.

deficiency; aneurin

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Alcohols	25307574	CTD
2	Fluorouracil	21941485	CTD
3	Pyrithiamine	27984051	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Folic Acid Deficiency	49.6%
2	Pellagra	49.6%
3	Vitamin B 12 Deficiency	49.6%
4	Vitamin B 6 Deficiency	49.6%
5	Pyridoxine Deficiency	49.6%
6	Ascorbic Acid Deficiency	36.8%
7	Vitamin A Deficiency	36.8%
8	Vitamin D Deficiency	36.8%
9	Vitamin E Deficiency	36.8%
10	Magnesium Deficiency	29.9%
11	Potassium Deficiency	29.9%
12	Protein Deficiency	29.9%
13	Starvation	25.5%
14	Refeeding Syndrome	25.5%
15	Anemia, Pernicious	24.8%
16	Hyperhomocysteinemia	22.5%
17	Child Nutrition Disorders	21.3%
18	Hypervitaminosis A	21.3%
19	Infant Nutrition Disorders	21.3%
20	Wasting Syndrome	19.4%
21	Vitamin K Deficiency	18.9%
22	Marasmus	17.8%
23	Metabolic Diseases	14.8%
24	Kwashiorkor	13.9%
25	Subacute Combined Degeneration	13.2%
26	Rickets	13%
27	Scurvy	12.4%
28	Osteomalacia	9%
29	Acid-Base Imbalance	7.1%
30	Calcium Metabolism Disorders	7.1%
31	Iron Metabolism Disorders	7.1%
32	Phosphorus Metabolism Disorders	7.1%
33	Water-Electrolyte Imbalance	7.1%
34	Lipid Metabolism Disorders	7.1%
35	Mitochondrial Diseases	7.1%
36	Glucose Metabolism Disorders	7.1%
37	Renal Osteodystrophy	5.7%
38	Renal rickets	5.7%
39	Hypercalcemia	4.9%
40	Hypocalcemia	4.9%
41	Milk-Alkali Syndrome	4.9%
42	HIV Wasting Syndrome	4.9%
43	Osteopenia	4.8%
44	Brain Diseases, Metabolic	4.7%
45	Obesity	4.3%
46	Lipodystrophy	3.7%
47	Acidosis	3.6%
48	Alkalosis	3.6%
49	Amyloidosis	3.6%
50	Calcinosis	3.6%
51	Hyperglycemia	3.6%
52	Hyperinsulinism	3.6%
53	Hyperkalemia	3.6%
54	Hypernatremia	3.6%
55	Hypoglycemia	3.6%
56	Hypokalemia	3.6%
57	Hyponatremia	3.6%
58	Xanthomatosis	3.6%
59	Hypophosphatemia	3.6%
60	Metabolic acidosis	3.6%
61	Dyslipidemias	3.6%
62	Iron Overload	3.6%
63	Xanthoma	3.6%
64	Familial Hypophosphatemic Rickets	3.5%
65	Pseudohypoparathyroidism	3.1%
66	Obesity, Abdominal	3%
67	Brain Diseases, Metabolic, Inborn	2.9%
68	Diabetes Mellitus	2.6%
69	Dehydration	2.5%
70	Lipomatosis	2.5%
71	Water Intoxication	2.5%
72	Werner Syndrome	2.5%
73	Achlorhydria	2.5%
74	Amino Acid Metabolism, Inborn Errors	2.5%
75	Bloom Syndrome	2.5%
76	Carbohydrate Metabolism, Inborn Errors	2.5%
77	Metal Metabolism, Inborn Errors	2.5%
78	Osteoporosis	2.5%
79	Progeria	2.5%
80	Lysosomal Storage Diseases	2.5%
81	Bone Demineralization, Pathologic	2.5%
82	Cytochrome-c Oxidase Deficiency	2.5%
83	Peroxisomal Disorders	2.5%
84	Post-Traumatic Osteoporosis	2.5%
85	Celiac Disease	2.4%
86	Sprue, Tropical	2.4%
87	Steatorrhea	2.4%
88	Sprue	2.4%
89	Pediatric Obesity	2.4%
90	Lactose Intolerance	2.3%
91	Leigh Disease	2.2%
92	Prader-Willi Syndrome	2%
93	Hypolipoproteinemias	2%
94	Acidosis, Lactic	2%
95	Calciphylaxis	2%
96	Hemosiderosis	2%
97	Ketosis	2%
98	Ketonuria	2%
99	Ketoacidosis	2%
100	Ketonemia	2%
101	Vascular calcification	2%
102	Mitochondrial Encephalomyopathies	1.9%
103	Mitochondrial Myopathies	1.9%
104	Myelinolysis, Central Pontine	1.9%
105	Glycosuria	1.8%
106	Reye Syndrome	1.8%
107	Hepatic Encephalopathy	1.8%
108	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
109	Smith-Lemli-Opitz Syndrome	1.7%
110	Galactosemias	1.7%
111	Urea Cycle Disorders, Inborn	1.7%
112	Tyrosinemias	1.7%
113	Congenital Hyperinsulinism	1.7%
114	Diabetic Ketoacidosis	1.6%
115	Hyperlipidemia, Familial Combined	1.6%
116	Hyperphosphaturia	1.5%
117	Porphyrias, Hepatic	1.5%
118	Necrobiosis Lipoidica Diabeticorum	1.5%
119	Fanconi Anemia	1.5%
120	Hyperlipoproteinemia Type IV	1.4%
121	Hyperlipoproteinemia Type V	1.4%
122	Hyperlipoproteinemia Type III	1.4%
123	Acidosis, Respiratory	1.3%
124	Adiposis Dolorosa	1.3%
125	Alkalosis, Respiratory	1.3%
126	Renal tubular acidosis	1.3%
127	Alkaptonuria	1.3%
128	Glycogen Storage Disease	1.3%
129	Hypophosphatasia	1.3%
130	Insulin Resistance	1.3%
131	Osteoporosis, Postmenopausal	1.3%
132	Propionic acidemia	1.3%
133	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
134	Cystinosis	1.3%
135	Homocystinuria	1.3%
136	Wernicke Encephalopathy	1.2%
137	Friedreich Ataxia	1.2%
138	Hypoalphalipoproteinemias	1.2%
139	Hypercholesterolemia	1.2%
140	Hyperlipoproteinemias	1.2%
141	Hypertriglyceridemia	1.2%
142	HIV-Associated Lipodystrophy Syndrome	1.2%
143	Zellweger Syndrome	1.1%
144	Amyloid Neuropathies, Familial	1.1%
145	Menkes Kinky Hair Syndrome	1.1%
146	Neuronal Ceroid-Lipofuscinoses	1.1%
147	Kernicterus	1.1%
148	Cockayne Syndrome	1.1%
149	Glycogen storage disease type II	1.1%
150	Gestational Diabetes	1.1%
151	Latent Autoimmune Diabetes in Adults	1.1%
152	MELAS Syndrome	1%
153	Diabetes Mellitus, Experimental	1%
154	Hepatolenticular Degeneration	1%
155	Nephrocalcinosis	1%
156	Tetany	1%
157	Refsum Disease	1%
158	Glycosuria, Renal	1%
159	Cerebral Amyloid Angiopathy	1%
160	Adrenoleukodystrophy	1%
161	Nesidioblastosis	1%
162	Ataxia Telangiectasia	0.9%
163	Optic Atrophy, Hereditary, Leber	0.9%
164	Kearns-Sayre syndrome	0.9%
165	Gaucher Disease	0.9%
166	Xeroderma Pigmentosum	0.8%
167	Familial Periodic Paralysis	0.8%
168	Primary amyloidosis	0.8%
169	Variegate Porphyria	0.8%
170	Acute intermittent porphyria	0.8%
171	Porphyria Cutanea Tarda	0.8%
172	Renal Aminoacidurias	0.8%
173	Fanconi Syndrome	0.8%
174	Pseudohypoaldosteronism	0.8%
175	Liddle Syndrome	0.8%
176	Mucopolysaccharidosis III	0.8%
177	Glycogen Storage Disease Type I	0.8%
178	Glycogen Storage Disease Type V	0.8%
179	Gout	0.7%
180	Amyotrophic Lateral Sclerosis	0.7%
181	Antley-Bixler Syndrome Phenotype	0.7%
182	Fabry Disease	0.7%
183	Sjogren-Larsson Syndrome	0.6%
184	CREST Syndrome	0.6%
185	Niemann-Pick Disease, Type C	0.6%
186	Canavan Disease	0.5%
187	Alexander Disease	0.5%
188	Mucopolysaccharidosis II	0.5%
189	Albinism	0.5%
190	Tay-Sachs Disease	0.5%
191	Hypokalemic periodic paralysis	0.5%
192	Frontotemporal dementia	0.5%
193	Cystinuria	0.5%
194	Ichthyosis, X-Linked	0.4%
195	Arthritis, Gouty	0.4%

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