MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Microphthalmos

(UMLS:C0026010)

Definition:: Congenital or developmental anomaly in which the eyeballs are abnormally small.
UMLS ID:: C0026010
MeSH ID:: D008850

Classification 1:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.250.566

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.384.666

Synonym(s)

Microphthalmos

Globe of eye small

Microphthalmia

Microphthalmos, NOS

Microphthalmos, unspecified

Nanophthalmos

Simple microphthalmos

Small eyeball

congenital microphthalmos

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Valproic Acid	FAERS: 14		US FAERS
2	Quetiapine Fumarate	FAERS: 8		US FAERS
3	Allopurinol	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
4	Isotretinoin	FAERS: 4		US FAERS
5	Metformin	FAERS: 4		US FAERS
6	Valproic Acid	FAERS: 4		US FAERS
7	zolmitriptan	FAERS: 4		US FAERS
8	Naproxen	FAERS: 3		US FAERS
9	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 2		US FAERS
10	Clomiphene	FAERS: 2		OFFSIDES US FAERS
11	Haloperidol	FAERS: 2		US FAERS
12	Lamotrigine	FAERS: 2		US FAERS
13	Mycophenolic Acid	FAERS: 2		US FAERS
14	Nitrofurantoin	FAERS: 2	19884587	CTD OFFSIDES US FAERS
15	Topiramate	FAERS: 2		US FAERS
16	Valproic Acid	FAERS: 2		US FAERS
17	Citalopram	FAERS: 1		US FAERS
18	Citalopram	FAERS: 1		US FAERS
19	Fluoxetine	FAERS: 1		US FAERS
20	Methimazole	FAERS: 1		US FAERS
21	Metoclopramide	FAERS: 1		US FAERS
22	Ondansetron	FAERS: 1		US FAERS
23	Paroxetine	FAERS: 1		US FAERS
24	Phenytoin	FAERS: 1	4441320	CTD US FAERS
25	Quetiapine Fumarate	FAERS: 1		US FAERS
26	Thyroxine	FAERS: 1		US FAERS
27	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
28	Zidovudine	FAERS: 1		US FAERS
29	sibutramine	FAERS: 1		US FAERS
30	Alcohols		21658441 24355176	CTD
31	Busulfan		17290349	CTD
32	Cadmium Compounds		19100278	CTD
33	Cladribine		12115775	CTD
34	Dacarbazine			OFFSIDES
35	Didanosine			OFFSIDES
36	Fluorouracil		29258758	CTD
37	Nelfinavir			OFFSIDES
38	Tamoxifen			OFFSIDES
39	Tenofovir			OFFSIDES
40	Thalidomide		4631040 8333272 28892372	CTD
41	Tretinoin			OFFSIDES
42	ochratoxin A		20036863	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Anophthalmos	44.8%
2	Blepharophimosis	41.7%
3	Retinal Dysplasia	35.6%
4	Aniridia	34.3%
5	Abnormalities, Drug-Induced	20.9%
6	Situs Inversus	20.9%
7	Beckwith-Wiedemann Syndrome	18.9%
8	Wolf-Hirschhorn Syndrome	18.9%
9	Aicardi's syndrome	18.3%
10	Holoprosencephaly	17%
11	CHARGE Syndrome	16.4%
12	Cardiovascular Abnormalities	16.4%
13	Smith-Magenis syndrome	15.9%
14	Skin Abnormalities	15.8%
15	Lymphatic Abnormalities	15.8%
16	Congenital Microtia	15.8%
17	Cri-du-Chat Syndrome	15.6%
18	Down Syndrome	15.6%
19	Trisomy 21	15.6%
20	Congenital diaphragmatic hernia	15.4%
21	Asthenopia	14.6%
22	Conjunctival Diseases	14.6%
23	Corneal Diseases	14.6%
24	Eyelid Diseases	14.6%
25	Lacrimal Apparatus Diseases	14.6%
26	Lens Diseases	14.6%
27	Ocular Hypertension	14.6%
28	Ocular Hypotension	14.6%
29	Retinal Diseases	14.6%
30	Scleral Diseases	14.6%
31	Vitreous Detachment	14.6%
32	Posterior Vitreous Detachment	14.6%
33	Anencephaly	14.1%
34	Retinal Degeneration	14%
35	Rubinstein-Taybi Syndrome	13.7%
36	Prune Belly Syndrome	13.6%
37	Twins, Conjoined	13.6%
38	Waardenburg Syndrome	13.6%
39	Ectodermal Dysplasia	13.5%
40	Aplasia Cutis Congenita	13.5%
41	Prader-Willi Syndrome	13.3%
42	Urogenital Abnormalities	13%
43	Genetic Diseases, Inborn	12.2%
44	Xerophthalmia	12.1%
45	Low Tension Glaucoma	12.1%
46	Iridocorneal endothelial syndrome	12.1%
47	Maxillofacial Abnormalities	11.9%
48	Dural Arteriovenous Fistula	11.9%
49	Dextrocardia	11.7%
50	Retinitis Pigmentosa	11.6%
51	Pigmentary retinopathy	11.6%
52	Duane Retraction Syndrome	11.5%
53	Uveal Neoplasms	11.1%
54	Eyelid Neoplasms	11%
55	Retinal Hemorrhage	11%
56	Eye Infection	10.9%
57	Eye Manifestations	10.9%
58	Eye Neoplasms	10.9%
59	Optic Neuropathy	10.9%
60	Kartagener Syndrome	10.8%
61	Keratoconjunctivitis Sicca	10.7%
62	Anus, Imperforate	10.3%
63	Hydranencephaly	10.3%
64	Nail-Patella Syndrome	10.3%
65	Neural Tube Defects	10.3%
66	Retinopathy of Prematurity	10.3%
67	Tethered Cord Syndrome	10.3%
68	Iniencephaly	10.3%
69	Craniorachischisis	10.3%
70	Limb Deformities, Congenital	10.3%
71	Exencephaly	10.3%
72	Septo-Optic Dysplasia	10.3%
73	Craniofacial Abnormalities	10.3%
74	Cortical Dysplasia	10.3%
75	Malformations of Cortical Development	10.3%
76	Anorectal Malformations	10.3%
77	Xeroderma	10.2%
78	Mobius Syndrome	10.2%
79	Marfan Syndrome	10.2%
80	Bloom Syndrome	10.2%
81	Keratoconjunctivitis	10.2%
82	Alstrom Syndrome	10.2%
83	Chorioretinitis	10.1%
84	Corneal Ulcer	9.6%
85	Choroid Hemorrhage	9.5%
86	Pars Planitis	9.4%
87	Angioid Streaks	9.3%
88	Anisometropia	9.3%
89	Aphakia	9.3%
90	Astigmatism	9.3%
91	Blepharitis	9.3%
92	Blepharoptosis	9.3%
93	Blepharospasm	9.3%
94	Choroid Diseases	9.3%
95	Conjunctivitis	9.3%
96	Corneal edema	9.3%
97	Corneal Opacity	9.3%
98	Dacryocystitis	9.3%
99	Dry Eye Syndromes	9.3%
100	Ectropion	9.3%
101	Enophthalmos	9.3%
102	Entropion	9.3%
103	Episcleritis	9.3%
104	Exophthalmos	9.3%
105	Glaucoma	9.3%
106	Iris Diseases	9.3%
107	Keratitis	9.3%
108	Keratoconus	9.3%
109	Lacrimal Duct Obstruction	9.3%
110	Lens dislocation	9.3%
111	Lens Subluxation	9.3%
112	Mydriasis	9.3%
113	Myopia	9.3%
114	Presbyopia	9.3%
115	Pterygium	9.3%
116	Retinal Detachment	9.3%
117	Retinitis	9.3%
118	Scleritis	9.3%
119	Uveitis	9.3%
120	Corneal Neovascularization	9.3%
121	Orbital Pseudotumor	9.3%
122	Cataract	9.3%
123	Pinguecula	9.3%
124	Trichiasis	9.3%
125	Fetal Diseases	9.1%
126	Microcephaly	9.1%
127	Macrocephaly	9.1%
128	Corneal Scar	9%
129	Scimitar Syndrome	9%
130	Polycystic Kidney Diseases	8.9%
131	Williams Syndrome	8.9%
132	Choroiditis	8.8%
133	Iridocyclitis	8.8%
134	Iritis	8.8%
135	Ocular Motility Disorders	8.7%
136	Cyclophoria	8.7%
137	Abnormalities, Radiation-Induced	8.6%
138	Pupil Disorders	8.6%
139	Craniosynostosis	8.5%
140	Syndactyly	8.5%
141	Brachycephaly	8.5%
142	Eye Hemorrhage	8.5%
143	Fragile X Syndrome	8.4%
144	Vision Disorders	8.4%
145	Metamorphopsia	8.4%
146	Visual Impairment	8.4%
147	Cockayne Syndrome	8.4%
148	Eye Injuries	8.3%
149	Laryngostenosis	8.3%
150	Mouth Abnormalities	8.3%
151	Esophageal Atresia	8.2%
152	Intestinal Atresia	8.2%
153	Horseshoe Kidney	8.2%
154	Pectus excavatum	8.2%
155	Porencephaly	8.2%
156	Klippel-Feil Syndrome	8.2%
157	Gastroschisis	8.2%
158	Synostosis	8.2%
159	Congenital nystagmus	8.2%
160	Acrodermatitis	8.1%
161	Lymphangiectasis, Intestinal	8.1%
162	Gianotti-Crosti Syndrome	8.1%
163	Acrocephalosyndactylia	8.1%
164	Classical Lissencephalies and Subcortical Band Heterotopias	8%
165	Hordeolum	7.9%
166	Color blindness	7.8%
167	Primary Ciliary Dyskinesia	7.8%
168	Epidermolysis Bullosa	7.7%
169	Amelia	7.6%
170	Arachnodactyly	7.6%
171	Ectopia Cordis	7.6%
172	Ectromelia	7.6%
173	Hemimelia	7.6%
174	Meningomyelocele	7.6%
175	Noonan Syndrome	7.6%
176	Phocomelia	7.6%
177	Sirenomelia	7.6%
178	Spina Bifida	7.6%
179	Polydactyly	7.6%
180	Brachydactyly	7.6%
181	Plagiocephaly	7.6%
182	Lower Extremity Deformities, Congenital	7.6%
183	Upper Extremity Deformities, Congenital	7.6%
184	Single umbilical artery	7.6%
185	Trachoma	7.4%
186	Mandibulofacial Dysostosis	7.4%
187	Smith-Lemli-Opitz Syndrome	7.4%
188	Retinoblastoma	7.4%
189	Turner Syndrome	7.4%
190	Ichthyosis, X-Linked	7.2%
191	Albinism	7.1%
192	Cystic Fibrosis	7.1%
193	Poland Syndrome	7%
194	Abdominal Cramps	7%
195	Amniotic Band Syndrome	7%
196	Arthrogryposis	7%
197	Asphyxia Neonatorum	7%
198	Choanal Atresia	7%
199	Infant, Premature, Diseases	7%
200	Tracheobronchomegaly	7%
201	Infantile Colic	7%
202	Laryngocele	7%
203	Jaw Abnormalities	6.9%
204	Cleft Palate	6.9%
205	Choledochal Cyst	6.9%
206	Endophthalmitis	6.9%
207	Hermaphroditism	6.9%
208	Optic Atrophy	6.9%
209	Optic Neuritis	6.9%
210	Papilledema	6.9%
211	Pemphigoid, Benign Mucous Membrane	6.9%
212	Retinal Artery Occlusion	6.9%
213	Disorders of Sex Development	6.9%
214	Strabismus	6.9%
215	Tolosa-Hunt Syndrome	6.9%
216	Orbital Cellulitis	6.9%
217	Retinal Vasculitis	6.9%
218	Hypertensive Retinopathy	6.9%
219	Retrobulbar Hemorrhage	6.9%
220	Corneal Endothelial Cell Loss	6.9%
221	Hyphema	6.8%
222	Retinal Neovascularization	6.8%
223	Vitreous Hemorrhage	6.8%
224	Acanthamoeba Keratitis	6.8%
225	Cryptorchidism	6.8%
226	Angle Closure Glaucoma	6.8%
227	Glaucoma, Open-Angle	6.8%
228	Macular degeneration	6.8%
229	Panuveitis	6.8%
230	Retinal Drusen	6.8%
231	Retinal Necrosis Syndrome, Acute	6.8%
232	Retinoschisis	6.8%
233	Exfoliation Syndrome	6.8%
234	Hypospadias	6.8%
235	Keratitis, Herpetic	6.8%
236	Cytomegalovirus Retinitis	6.8%
237	Central Nervous System Cysts	6.8%
238	Dandy-Walker Syndrome	6.7%
239	Bacterial conjunctivitis	6.7%
240	POEMS Syndrome	6.7%
241	Ophthalmia Neonatorum	6.6%
242	Corneal Perforation	6.6%
243	Polycystic Kidney, Autosomal Dominant	6.5%
244	Klinefelter Syndrome	6.3%
245	Dermal Sinus	6.2%
246	Spina Bifida Cystica	6.2%
247	Spina Bifida Occulta	6.2%
248	Lissencephaly	6.2%
249	Polymicrogyria	6.2%
250	Pachygyria	6.2%
251	Schizencephaly	6.2%
252	Periventricular Nodular Heterotopia	6.2%
253	Optic Atrophy, Hereditary, Leber	6.2%
254	Aortic coarctation	6%
255	Cor Triatriatum	6%
256	Coronary Vessel Anomalies	6%
257	Dental Enamel Hypoplasia	6%
258	Patent ductus arteriosus	6%
259	Ebstein Anomaly	6%
260	Heart Septal Defects	6%
261	Hypodontia	6%
262	Macrostomia	6%
263	Meningocele	6%
264	Microstomia	6%
265	Tetralogy of Fallot	6%
266	Transposition of Great Vessels	6%
267	Hypoplastic Left Heart Syndrome	6%
268	May-Thurner Syndrome	6%
269	Encephalocele	6%
270	Craniofacial Dysostosis	6%
271	Pseudoxanthoma Elasticum	6%
272	Wolff-Parkinson-White Syndrome	6%
273	Meconium Aspiration Syndrome	5.9%
274	Laryngomalacia	5.9%
275	Pectus carinatum	5.9%
276	Micrognathism	5.8%
277	Pierre Robin Syndrome	5.8%
278	Sjogren-Larsson Syndrome	5.8%
279	Bladder Exstrophy	5.8%
280	Epispadias	5.8%
281	Multicystic Dysplastic Kidney	5.8%
282	Charcot-Marie-Tooth Disease	5.6%
283	Antley-Bixler Syndrome Phenotype	5.6%
284	Anterior uveitis	5.6%
285	Uveitis, Posterior	5.6%
286	Kallmann Syndrome	5.6%
287	Optic Neuropathy, Ischemic	5.6%
288	Anterior Ischemic Optic Neuropathy	5.6%
289	Hyperkeratosis, Epidermolytic	5.5%
290	Retinal Vein Occlusion	5.5%
291	Neoplastic Syndromes, Hereditary	5.5%
292	Anisocoria	5.4%
293	Diabetic Retinopathy	5.4%
294	Tonic Pupil	5.4%
295	Eye pain	5.4%
296	Orbital Myositis	5.4%
297	Panophthalmitis	5.4%
298	Xeroderma Pigmentosum	5.4%
299	Diplopia	5.4%
300	Scotoma	5.4%
301	Photophobia	5.4%
302	Amaurosis	5.4%
303	Blindness	5.4%
304	Retrognathia	5.2%
305	Anemia, Neonatal	5.2%
306	Multiple Epiphyseal Dysplasia	5.2%
307	Osteochondrodysplasias	5.2%
308	Pelger-Huet Anomaly	5.2%
309	Persistent Fetal Circulation Syndrome	5.2%
310	Werner Syndrome	5.2%
311	Myasthenic Syndromes, Congenital	5.2%
312	Umbilical hernia	5.1%
313	Esotropia	5%
314	Exotropia	5%
315	Choroidal Neovascularization	5%
316	Long QT Syndrome	5%
317	Platybasia	5%
318	Tricuspid Atresia	5%
319	Arrhythmogenic Right Ventricular Dysplasia	5%
320	Gonadal Dysgenesis	5%
321	Bronchomalacia	5%
322	Adrenogenital Syndrome	5%
323	Tracheomalacia	5%
324	Ovotesticular Disorders of Sex Development	5%
325	Zellweger Syndrome	5%
326	Aortopulmonary Septal Defect	5%
327	Double Outlet Right Ventricle	5%
328	Endocardial Cushion Defects	5%
329	Myocardial bridging	5%
330	Aorticopulmonary Septal Defect	5%
331	Hyperandrogenism	4.9%
332	Basal Cell Nevus Syndrome	4.8%
333	Tuberous Sclerosis	4.8%
334	Prognathism	4.7%
335	Familial Mediterranean Fever	4.5%
336	Ophthalmoplegia	4.5%
337	External Ophthalmoplegia	4.5%
338	Refsum Disease	4.5%
339	Amblyopia	4.5%
340	Anemia, Sickle Cell	4.5%
341	Thalassemia	4.5%
342	Muscular Dystrophy, Duchenne	4.4%
343	Truncus Arteriosus, Persistent	4.4%
344	Goldenhar Syndrome	4.4%
345	Dwarfism	4.3%
346	Neonatal Abstinence Syndrome	4.2%
347	Fetal Growth Retardation	4.1%
348	Romano-Ward Syndrome	4.1%
349	Uveomeningoencephalitic Syndrome	4.1%
350	Muscular Dystrophy	4.1%
351	Osteogenesis Imperfecta	4.1%
352	Fetal Hypoxia	4.1%
353	Fetal Alcohol Spectrum Disorders	4.1%
354	Herpes Zoster Ophthalmicus	4.1%
355	Toxoplasmosis, Congenital	4%
356	Syphilis, Congenital	4%
357	Hemianopsia	4%
358	Amaurosis Fugax	4%
359	Blindness, Cortical	4%
360	Rett Syndrome	4%
361	Talipes	3.7%
362	Mucopolysaccharidosis II	3.6%
363	Behcet Syndrome	3.6%
364	Congenital clubfoot	3.5%
365	Vertical Talus	3.5%
366	Paralysis, Obstetric	3.4%
367	Autoimmune Lymphoproliferative Syndrome	3.4%
368	Graves Disease	3.4%
369	Congenital Hyperinsulinism	3.4%
370	Amino Acid Metabolism, Inborn Errors	3.4%
371	Carbohydrate Metabolism, Inborn Errors	3.4%
372	Chorioamnionitis	3.4%
373	Metal Metabolism, Inborn Errors	3.4%
374	Progeria	3.4%
375	Lysosomal Storage Diseases	3.4%
376	Cytochrome-c Oxidase Deficiency	3.4%
377	Peroxisomal Disorders	3.4%
378	Bronchopulmonary Dysplasia	3.4%
379	Horner Syndrome	3.4%
380	Angioedemas, Hereditary	3.4%
381	Wiskott-Aldrich Syndrome	3.3%
382	Sickle Cell Trait	3.3%
383	Menkes Kinky Hair Syndrome	3.3%
384	Arteriovenous fistula	3.1%
385	Neuronal Ceroid-Lipofuscinoses	3.1%
386	Opsoclonus-Myoclonus Syndrome	3%
387	Myotonic Dystrophy	2.9%
388	Respiratory Distress Syndrome, Newborn	2.8%
389	Cutis Laxa	2.7%
390	Porokeratosis	2.7%
391	Keratoderma, Palmoplantar	2.7%
392	Chronic granulomatous disease	2.7%
393	Welander Distal Myopathy	2.7%
394	Miller Fisher Syndrome	2.6%
395	Adrenoleukodystrophy	2.6%
396	Kearns-Sayre syndrome	2.6%
397	Amyloid Neuropathies, Familial	2.6%
398	Hepatolenticular Degeneration	2.5%
399	Acute Chest Syndrome	2.5%
400	Alkaptonuria	2.5%
401	Glycogen Storage Disease	2.5%
402	Hypophosphatasia	2.5%
403	Propionic acidemia	2.5%
404	Dihydropyrimidine Dehydrogenase Deficiency	2.5%
405	Cystinosis	2.5%
406	Sicca Syndrome	2.5%
407	Sjogren's Syndrome	2.5%
408	Fabry Disease	2.5%
409	Galactosemias	2.5%
410	Urea Cycle Disorders, Inborn	2.5%
411	Tyrosinemias	2.5%
412	Denys-Drash Syndrome	2.4%
413	Glycogen storage disease type II	2.4%
414	Hydrops Fetalis	2.4%
415	Mucopolysaccharidosis III	2.3%
416	Porphyrias, Hepatic	2.3%
417	Ataxia Telangiectasia	2.3%
418	Peutz-Jeghers Syndrome	2.2%
419	Myotonia Congenita	2.2%
420	Thrombasthenia	2.2%
421	Antithrombin III Deficiency	2.2%
422	Protein C Deficiency	2.2%
423	Brain Diseases, Metabolic, Inborn	2.2%
424	Ophthalmoplegic Migraine	2.2%
425	Afibrinogenemia	2.2%
426	Dystonia Musculorum Deformans	2.2%
427	Factor VII Deficiency	2.2%
428	Factor X Deficiency	2.2%
429	Factor XII Deficiency	2.2%
430	Hemophilia A	2.2%
431	Leukomalacia, Periventricular	2.2%
432	Activated Protein C Resistance	2.2%
433	Factor II deficiency	2.2%
434	Factor VIII Deficiency	2.2%
435	Factor V deficiency	2.2%
436	Factor XI Deficiency	2.2%
437	Hypoprothrombinemias	2.2%
438	Fanconi Anemia	2.2%
439	Nesidioblastosis	2.2%
440	Progressive supranuclear palsy	2.2%
441	Lafora Disease	2.2%
442	Unverricht-Lundborg Syndrome	2.2%
443	Anemia, Diamond-Blackfan	2.2%
444	Hyperphosphaturia	2.2%
445	Canavan Disease	2.1%
446	Alexander Disease	2.1%
447	Glycogen Storage Disease Type I	2.1%
448	Glycogen Storage Disease Type V	2.1%
449	Hyaline Membrane Disease	2%
450	Homocystinuria	2%
451	Leigh Disease	2%
452	Hypolipoproteinemias	2%
453	Papillon-Lefevre Disease	2%
454	Hyperlipidemia, Familial Combined	2%
455	Multiple Endocrine Neoplasia	2%
456	Hyperlipoproteinemia Type III	2%
457	Neuromyelitis Optica	2%
458	Gaucher Disease	2%
459	Congenital Hypothyroidism	1.9%
460	Dermatitis, Atopic	1.9%
461	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.8%
462	Tay-Sachs Disease	1.8%
463	Niemann-Pick Disease, Type C	1.7%
464	Kernicterus	1.7%
465	Familial Periodic Paralysis	1.7%
466	Lactose Intolerance	1.7%
467	Variegate Porphyria	1.7%
468	Acute intermittent porphyria	1.7%
469	Porphyria Cutanea Tarda	1.7%
470	Hyperhomocysteinemia	1.7%
471	Renal Aminoacidurias	1.6%
472	Fanconi Syndrome	1.6%
473	Pseudohypoaldosteronism	1.6%
474	Liddle Syndrome	1.6%
475	Hypoalphalipoproteinemias	1.6%
476	Hyperlipoproteinemia Type IV	1.6%
477	Hyperlipoproteinemia Type V	1.6%
478	Optic Nerve Glioma	1.6%
479	Huntington Disease	1.5%
480	Gout	1.4%
481	Multiple Endocrine Neoplasia Type 1	1.4%
482	Pseudohypoparathyroidism	1.4%
483	Friedreich Ataxia	1.4%
484	Renal tubular acidosis	1.4%
485	Hypokalemic periodic paralysis	1.4%
486	Cystinuria	1.4%
487	Nephroblastoma	1.3%
488	Adenomatous Polyposis Coli	1.2%
489	Arthritis, Gouty	1.2%
490	Familial Hypophosphatemic Rickets	1.1%
491	Glycosuria, Renal	1.1%
492	MELAS Syndrome	0.9%

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