MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Anemia, Sickle Cell

(UMLS:C0002895)

Definition:: A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
UMLS ID:: C0002895
MeSH ID:: D000755

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.071.141.150.150|C15.378.420.155

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.070.150|C16.320.365.155

Synonym(s)

Anemia, Sickle Cell

Anaemia;sickle cell

Drepanocythemia

HERRICK SYNDROME

Haemoglobin S disease

Haemoglobin S-S disease

Hb S disease

Hb SS disease

Hb-SS disease

10.

Hemoglobin S disease

11.

Hemoglobin S-S disease

12.

Hemoglobin SS disease

13.

Hereditary hemoglobinopathy disorder homozygous for hemoglobin S

14.

Herrick

15.

Herrick; anemia

16.

SICKLE CELL ANEMIA

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aspartame	11372003	CTD
2	Aspirin-oxycodone hydrochloride-oxycodone terephthalate combination	18593679	CTD
3	Baclofen	18593679	CTD
4	Deferasirox	17233848	CTD
5	Deferoxamine	9106087 17233848 20721892	CTD
6	Folic Acid	18593679	CTD
7	Hydromorphone	1373356	CTD
8	Hydroxyurea	View details 9256830 14965870 15692605 16628721 17686055 18458272 19724057	CTD
9	Meperidine	View details 1373356 1611370 7847116 10456240	CTD
10	Methylprednisolone	18717146	CTD
11	Nalbuphine	1373356	CTD
12	Oxygen	29255069	CTD
13	Paclitaxel	18593679	CTD
14	Pentoxifylline	3308412	CTD
15	Prednisone	18717146	CTD
16	Vitamin E	15997260	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Thalassemia	63.4%
2	Thrombasthenia	31.5%
3	Antithrombin III Deficiency	31.5%
4	Protein C Deficiency	31.5%
5	Pelger-Huet Anomaly	30.9%
6	Wiskott-Aldrich Syndrome	30.1%
7	Afibrinogenemia	29%
8	Factor VII Deficiency	29%
9	Factor X Deficiency	29%
10	Factor XII Deficiency	29%
11	Hemophilia A	29%
12	Activated Protein C Resistance	29%
13	Factor II deficiency	29%
14	Factor VIII Deficiency	29%
15	Factor V deficiency	29%
16	Factor XI Deficiency	29%
17	Hypoprothrombinemias	29%
18	Anemia, Diamond-Blackfan	27.9%
19	Disseminated Intravascular Coagulation	27.7%
20	Protein S Deficiency	27.7%
21	Thrombocythemia, Essential	25.8%
22	Hemoglobinuria, Paroxysmal	24.5%
23	Anemia, Neonatal	23.1%
24	Aicardi's syndrome	22.1%
25	Hydrops Fetalis	21.9%
26	Fragile X Syndrome	21.7%
27	Blood Coagulation Disorders	21.1%
28	Blood Platelet Disorders	21.1%
29	Bone Marrow Diseases	21.1%
30	Hemorrhagic Disorders	21.1%
31	Leukocyte Disorders	21.1%
32	Methemoglobinemia	21.1%
33	Pancytopenia	21.1%
34	Polycythemia	21.1%
35	Sulfhemoglobinemia	21.1%
36	Thrombophilia	21.1%
37	Erythrocytosis	21.1%
38	CHARGE Syndrome	21%
39	Neoplastic Syndromes, Hereditary	20.7%
40	Cystic Fibrosis	20.6%
41	Ichthyosis, X-Linked	20.2%
42	Multiple Epiphyseal Dysplasia	20.1%
43	Osteochondrodysplasias	20.1%
44	Werner Syndrome	20.1%
45	Myasthenic Syndromes, Congenital	20.1%
46	Fanconi Anemia	20%
47	Albinism	19.8%
48	Muscular Dystrophy, Duchenne	19.7%
49	Anemia, Macrocytic	19.5%
50	Beckwith-Wiedemann Syndrome	18.9%
51	Wolf-Hirschhorn Syndrome	18.9%
52	Nail-Patella Syndrome	18.5%
53	Cockayne Syndrome	18.5%
54	Bone Marrow Neoplasms	18.4%
55	Vitamin K Deficiency	18.3%
56	Transfusion Reaction	18.2%
57	Hypotensive Transfusion Reaction	18.2%
58	Alstrom Syndrome	18.1%
59	Thrombocytosis	18.1%
60	Autoimmune Lymphoproliferative Syndrome	17.9%
61	Pregnancy Complications, Hematologic	17.7%
62	Hematologic Neoplasms	17.7%
63	Mucopolysaccharidosis II	17.7%
64	Dwarfism	17.7%
65	Chronic granulomatous disease	17.6%
66	Muscular Dystrophy	17.1%
67	Osteogenesis Imperfecta	17.1%
68	Hemolytic-Uremic Syndrome	17%
69	Rett Syndrome	16.7%
70	Smith-Magenis syndrome	16.7%
71	Menkes Kinky Hair Syndrome	16.7%
72	Polycythemia Vera	16.5%
73	Cri-du-Chat Syndrome	16.5%
74	Down Syndrome	16.5%
75	Trisomy 21	16.5%
76	Kartagener Syndrome	16.2%
77	Anemia, Sickle Cell	16%
78	Familial Mediterranean Fever	15.8%
79	Holoprosencephaly	15.6%
80	Marfan Syndrome	15.2%
81	Angioedemas, Hereditary	14.8%
82	Ectodermal Dysplasia	14.7%
83	Aplasia Cutis Congenita	14.7%
84	Leukemoid Reaction	14.7%
85	Prader-Willi Syndrome	14.6%
86	Smith-Lemli-Opitz Syndrome	14.4%
87	Myotonic Dystrophy	14.3%
88	Neuronal Ceroid-Lipofuscinoses	14.2%
89	Adrenoleukodystrophy	14%
90	Purpura, Thrombotic Thrombocytopenic	14%
91	Pseudoxanthoma Elasticum	13.8%
92	Rubinstein-Taybi Syndrome	13.8%
93	Deformity	13.7%
94	Tuberous Sclerosis	13.7%
95	Kallmann Syndrome	13.5%
96	Sjogren-Larsson Syndrome	13.3%
97	Amino Acid Metabolism, Inborn Errors	13.2%
98	Carbohydrate Metabolism, Inborn Errors	13.2%
99	Metal Metabolism, Inborn Errors	13.2%
100	Progeria	13.2%
101	Lysosomal Storage Diseases	13.2%
102	Cytochrome-c Oxidase Deficiency	13.2%
103	Peroxisomal Disorders	13.2%
104	Hepatolenticular Degeneration	13.1%
105	Polycystic Kidney Diseases	13.1%
106	Williams Syndrome	13.1%
107	Primary Ciliary Dyskinesia	13%
108	Refsum Disease	13%
109	Fabry Disease	12.9%
110	Eosinophilia	12.9%
111	Hypoproteinemia	12.9%
112	Leukopenia	12.9%
113	Thrombocytopenia	12.9%
114	Leukostasis	12.9%
115	MYELODYSPLASTIC SYNDROME	12.9%
116	Anemia, Megaloblastic	12.8%
117	Lymphatic Diseases	12.7%
118	Atypical Hemolytic Uremic Syndrome	12.7%
119	Lymphatic Abnormalities	12.7%
120	Amyloid Neuropathies, Familial	12.4%
121	Agammaglobulinemia	12.4%
122	Retinal Dysplasia	12.1%
123	Anemia	12%
124	Glycogen storage disease type II	12%
125	Aniridia	12%
126	Sickle Cell Trait	11.9%
127	Epidermolysis Bullosa	11.8%
128	Galactosemias	11.7%
129	Urea Cycle Disorders, Inborn	11.7%
130	Tyrosinemias	11.7%
131	Autoimmune thrombocytopenia	11.7%
132	Immune thrombocytopenic purpura	11.7%
133	Fetal Diseases	11.5%
134	Cutis Laxa	11.5%
135	Retinitis Pigmentosa	11.4%
136	Pigmentary retinopathy	11.4%
137	Porokeratosis	11.3%
138	Keratoderma, Palmoplantar	11.3%
139	Welander Distal Myopathy	11.2%
140	Cryoglobulinemia	11.1%
141	Monoclonal Gammopathy of Undetermined Significance	11.1%
142	Waldenstrom Macroglobulinemia	11%
143	Ataxia Telangiectasia	10.9%
144	Leukocytosis	10.9%
145	Paraproteinemias	10.9%
146	Pleocytosis	10.9%
147	Mucopolysaccharidosis III	10.8%
148	Infectious Mononucleosis	10.7%
149	Optic Atrophy, Hereditary, Leber	10.7%
150	Hyperphosphaturia	10.6%
151	Canavan Disease	10.6%
152	Alexander Disease	10.6%
153	Zellweger Syndrome	10.3%
154	Duane Retraction Syndrome	10.1%
155	Porphyrias, Hepatic	10%
156	Gaucher Disease	9.9%
157	Lymphangiectasis, Intestinal	9.9%
158	Peutz-Jeghers Syndrome	9.9%
159	Myotonia Congenita	9.9%
160	Brain Diseases, Metabolic, Inborn	9.9%
161	Classical Lissencephalies and Subcortical Band Heterotopias	9.9%
162	Dystonia Musculorum Deformans	9.9%
163	Alkaptonuria	9.8%
164	Glycogen Storage Disease	9.8%
165	Hypophosphatasia	9.8%
166	Propionic acidemia	9.8%
167	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
168	Cystinosis	9.8%
169	Purpura, Hyperglobulinemic	9.8%
170	Homocystinuria	9.8%
171	Lafora Disease	9.8%
172	Unverricht-Lundborg Syndrome	9.8%
173	Leigh Disease	9.7%
174	Polycystic Kidney, Autosomal Dominant	9.7%
175	Acute Chest Syndrome	9.7%
176	Niemann-Pick Disease, Type C	9.5%
177	Heavy Chain Disease	9.4%
178	Hypergammaglobulinemia	9.4%
179	Hyperkeratosis, Epidermolytic	9.4%
180	Transfusion-Related Acute Lung Injury	9.3%
181	Ecchymosis	9.2%
182	Petechiae	9.2%
183	Purpura	9.2%
184	Kernicterus	9.2%
185	Tay-Sachs Disease	9.1%
186	Meconium Aspiration Syndrome	9%
187	Multiple Endocrine Neoplasia	9%
188	Xeroderma Pigmentosum	8.9%
189	Multiple Myeloma	8.9%
190	Thrombocytopenic purpura	8.9%
191	Congenital Hypothyroidism	8.9%
192	Primary Myelofibrosis	8.9%
193	Agranulocytosis	8.9%
194	Lymphocytosis	8.9%
195	Myelofibrosis	8.9%
196	Myeloid Metaplasia	8.9%
197	Hypoalbuminemia	8.9%
198	Hypereosinophilic syndrome	8.9%
199	bone marrow fibrosis	8.9%
200	Thrombotic Microangiopathies	8.9%
201	Dermatitis, Atopic	8.8%
202	POEMS Syndrome	8.8%
203	Carbamoyl-Phosphate Synthase I Deficiency Disease	8.8%
204	Charcot-Marie-Tooth Disease	8.7%
205	Antley-Bixler Syndrome Phenotype	8.7%
206	Hypolipoproteinemias	8.4%
207	Papillon-Lefevre Disease	8.4%
208	Hyperlipidemia, Familial Combined	8.4%
209	Hyperlipoproteinemia Type III	8.4%
210	Xeroderma	8.4%
211	Mobius Syndrome	8.4%
212	Waterhouse-Friderichsen Syndrome	8.2%
213	Glycogen Storage Disease Type I	8.1%
214	Glycogen Storage Disease Type V	8.1%
215	Basal Cell Nevus Syndrome	8.1%
216	Abdominal Cramps	8%
217	Abnormalities, Drug-Induced	8%
218	Amniotic Band Syndrome	8%
219	Asphyxia Neonatorum	8%
220	Infant, Premature, Diseases	8%
221	Situs Inversus	8%
222	Infantile Colic	8%
223	Behcet Syndrome	7.9%
224	Anemia, Hemolytic	7.9%
225	Anemia, Pernicious	7.8%
226	Lymphopenia	7.5%
227	Familial Periodic Paralysis	7.5%
228	Job Syndrome	7.4%
229	Klinefelter Syndrome	7.4%
230	Lactose Intolerance	7.4%
231	Variegate Porphyria	7.4%
232	Acute intermittent porphyria	7.4%
233	Porphyria Cutanea Tarda	7.4%
234	Leukemia, Myelomonocytic, Chronic	7.4%
235	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	7.4%
236	Hyperhomocysteinemia	7.3%
237	Renal Aminoacidurias	7.3%
238	Fanconi Syndrome	7.3%
239	Pseudohypoaldosteronism	7.3%
240	Liddle Syndrome	7.3%
241	Hyperlipoproteinemia Type IV	7.3%
242	Hyperlipoproteinemia Type V	7.3%
243	Huntington Disease	7.2%
244	Adenitis	7%
245	Histiocytosis	7%
246	Lymphadenitis	7%
247	Lymphangitis	7%
248	Lymphedema	7%
249	Splenic Diseases	7%
250	Thymus Hyperplasia	7%
251	Pseudolymphoma	7%
252	Lymphadenopathy	7%
253	Hypoalphalipoproteinemias	6.9%
254	Eye Abnormalities	6.9%
255	Cardiovascular Abnormalities	6.9%
256	Neutropenia	6.9%
257	Turner Syndrome	6.9%
258	Skin Abnormalities	6.8%
259	Congenital Microtia	6.8%
260	Persistent Fetal Circulation Syndrome	6.7%
261	Congenital diaphragmatic hernia	6.6%
262	Gout	6.6%
263	Umbilical hernia	6.6%
264	Eosinophilic Granuloma	6.6%
265	Anencephaly	6.6%
266	Multiple Endocrine Neoplasia Type 1	6.6%
267	Pseudohypoparathyroidism	6.6%
268	Nephroblastoma	6.6%
269	Friedreich Ataxia	6.5%
270	Renal tubular acidosis	6.5%
271	Eosinophilia-Myalgia Syndrome	6.4%
272	Shwartzman Phenomenon	6.4%
273	Hemangioma, Cavernous	6.3%
274	Scurvy	6.3%
275	Purpura Fulminans	6.3%
276	Hypokalemic periodic paralysis	6.1%
277	Cystinuria	6.1%
278	Adenomatous Polyposis Coli	6%
279	Familial Hypophosphatemic Rickets	6%
280	Urogenital Abnormalities	6%
281	Lymphocele	5.9%
282	Lymphoproliferative Disorders	5.9%
283	Febrile Neutropenia	5.9%
284	Thymus Neoplasms	5.8%
285	Neonatal Abstinence Syndrome	5.8%
286	Maxillofacial Abnormalities	5.8%
287	Dural Arteriovenous Fistula	5.8%
288	Pulmonary Eosinophilia	5.8%
289	Eosinophilic Pneumonia	5.8%
290	Dextrocardia	5.8%
291	Fetal Growth Retardation	5.7%
292	Fetal Hypoxia	5.7%
293	Congenital nystagmus	5.7%
294	Fetal Alcohol Spectrum Disorders	5.7%
295	Leukemia, Myeloid, Chronic-Phase	5.7%
296	Toxoplasmosis, Congenital	5.7%
297	Syphilis, Congenital	5.6%
298	Arthritis, Gouty	5.4%
299	Glycosuria, Renal	5.3%
300	Prune Belly Syndrome	5.3%
301	Twins, Conjoined	5.3%
302	Waardenburg Syndrome	5.3%
303	Mucocutaneous Lymph Node Syndrome	5%
304	Congenital Hyperinsulinism	5%
305	Chorioamnionitis	5%
306	Scimitar Syndrome	4.7%
307	Denys-Drash Syndrome	4.6%
308	Acrocephalosyndactylia	4.6%
309	Microcephaly	4.5%
310	Macrocephaly	4.5%
311	MELAS Syndrome	4.5%
312	Anophthalmos	4.5%
313	Anus, Imperforate	4.5%
314	Hydranencephaly	4.5%
315	Microphthalmos	4.5%
316	Neural Tube Defects	4.5%
317	Paralysis, Obstetric	4.5%
318	Retinopathy of Prematurity	4.5%
319	Tethered Cord Syndrome	4.5%
320	Iniencephaly	4.5%
321	Craniorachischisis	4.5%
322	Limb Deformities, Congenital	4.5%
323	Exencephaly	4.5%
324	Septo-Optic Dysplasia	4.5%
325	Craniofacial Abnormalities	4.5%
326	Cortical Dysplasia	4.5%
327	Malformations of Cortical Development	4.5%
328	Anorectal Malformations	4.5%
329	Abnormalities, Radiation-Induced	4.4%
330	Bloom Syndrome	4.4%
331	Bronchopulmonary Dysplasia	4.4%
332	Craniosynostosis	4.4%
333	Syndactyly	4.4%
334	Brachycephaly	4.4%
335	Elephantiasis	4.3%
336	Hypersplenism	4.3%
337	Sarcoidosis	4.3%
338	Elephantiasis Nostras Verrucosa	4.3%
339	Porencephaly	4.1%
340	Noonan Syndrome	4%
341	Ophthalmia Neonatorum	3.9%
342	Cleft Palate	3.9%
343	Blepharophimosis	3.9%
344	Laryngostenosis	3.9%
345	Mouth Abnormalities	3.9%
346	Respiratory Distress Syndrome, Newborn	3.9%
347	Esophageal Atresia	3.8%
348	Intestinal Atresia	3.8%
349	Horseshoe Kidney	3.8%
350	Pectus excavatum	3.8%
351	Klippel-Feil Syndrome	3.8%
352	Gastroschisis	3.8%
353	Synostosis	3.8%
354	Acrodermatitis	3.8%
355	Gianotti-Crosti Syndrome	3.8%
356	Jaw Abnormalities	3.7%
357	Granuloma	3.6%
358	Histiocytic Disorders, Malignant	3.6%
359	Splenic Infarction	3.6%
360	Splenic Neoplasms	3.6%
361	Poland Syndrome	3.6%
362	Histiocytosis, Langerhans-Cell	3.6%
363	Tumor Lysis Syndrome	3.6%
364	Arthrogryposis	3.4%
365	Choanal Atresia	3.4%
366	Tracheobronchomegaly	3.4%
367	Laryngocele	3.4%
368	Choledochal Cyst	3.4%
369	Hermaphroditism	3.4%
370	Disorders of Sex Development	3.4%
371	Cryptorchidism	3.3%
372	Hypospadias	3.3%
373	Sezary Syndrome	3.3%
374	Central Nervous System Cysts	3.3%
375	Dandy-Walker Syndrome	3.3%
376	Amelia	3.3%
377	Arachnodactyly	3.3%
378	Ectopia Cordis	3.3%
379	Ectromelia	3.3%
380	Hemimelia	3.3%
381	Meningomyelocele	3.3%
382	Phocomelia	3.3%
383	Sirenomelia	3.3%
384	Spina Bifida	3.3%
385	Polydactyly	3.3%
386	Brachydactyly	3.3%
387	Plagiocephaly	3.3%
388	Lower Extremity Deformities, Congenital	3.3%
389	Upper Extremity Deformities, Congenital	3.3%
390	Single umbilical artery	3.3%
391	Leukomalacia, Periventricular	3.3%
392	Nesidioblastosis	3.3%
393	Splenic Rupture	3.1%
394	Lymphoma	3.1%
395	Micrognathism	3.1%
396	Pierre Robin Syndrome	3.1%
397	Thymoma	3.1%
398	Laryngomalacia	3%
399	Pectus carinatum	3%
400	Bladder Exstrophy	3%
401	Epispadias	3%
402	Lymphohistiocytosis, Hemophagocytic	3%
403	Erdheim-Chester Disease	3%
404	Multicystic Dysplastic Kidney	2.9%
405	Aortic coarctation	2.8%
406	Cor Triatriatum	2.8%
407	Coronary Vessel Anomalies	2.8%
408	Dental Enamel Hypoplasia	2.8%
409	Patent ductus arteriosus	2.8%
410	Ebstein Anomaly	2.8%
411	Heart Septal Defects	2.8%
412	Hyaline Membrane Disease	2.8%
413	Hypodontia	2.8%
414	Macrostomia	2.8%
415	Meningocele	2.8%
416	Microstomia	2.8%
417	Tetralogy of Fallot	2.8%
418	Transposition of Great Vessels	2.8%
419	Hypoplastic Left Heart Syndrome	2.8%
420	May-Thurner Syndrome	2.8%
421	Encephalocele	2.8%
422	Retrognathia	2.8%
423	Craniofacial Dysostosis	2.8%
424	Wolff-Parkinson-White Syndrome	2.8%
425	Dermal Sinus	2.7%
426	Spina Bifida Cystica	2.7%
427	Spina Bifida Occulta	2.7%
428	Lissencephaly	2.7%
429	Polymicrogyria	2.7%
430	Pachygyria	2.7%
431	Schizencephaly	2.7%
432	Periventricular Nodular Heterotopia	2.7%
433	Hyperandrogenism	2.7%
434	Prognathism	2.6%
435	Long QT Syndrome	2.5%
436	Platybasia	2.5%
437	Tricuspid Atresia	2.5%
438	Arrhythmogenic Right Ventricular Dysplasia	2.5%
439	Malignant histiocytosis	2.5%
440	Sarcoidosis, Pulmonary	2.5%
441	Histiocytic sarcoma	2.5%
442	Gonadal Dysgenesis	2.5%
443	Bronchomalacia	2.5%
444	Adrenogenital Syndrome	2.5%
445	Tracheomalacia	2.5%
446	Ovotesticular Disorders of Sex Development	2.5%
447	Aortopulmonary Septal Defect	2.3%
448	Double Outlet Right Ventricle	2.3%
449	Endocardial Cushion Defects	2.3%
450	Myocardial bridging	2.3%
451	Aorticopulmonary Septal Defect	2.3%
452	Splenosis	2.1%
453	Hodgkin Disease	2.1%
454	Lymphoma, Non-Hodgkin	2.1%
455	Leukemia, T-Cell	2.1%
456	Leukemia, B-Cell	2.1%
457	Truncus Arteriosus, Persistent	2.1%
458	Goldenhar Syndrome	2.1%
459	Mandibulofacial Dysostosis	2%
460	Romano-Ward Syndrome	2%
461	Composite Lymphoma	1.8%
462	Talipes	1.8%
463	Lymphangioleiomyomatosis	1.8%
464	Congenital clubfoot	1.7%
465	Vertical Talus	1.7%
466	Arteriovenous fistula	1.6%
467	Lymphoma, Follicular	1.6%
468	T-Cell Lymphoma	1.6%
469	Mantle cell lymphoma	1.6%
470	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
471	Leukemia, Large Granular Lymphocytic	1.6%
472	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.6%
473	Lymphoma, T-Cell, Cutaneous	1.4%
474	Lymphoma, AIDS-Related	1.4%
475	Enteropathy-Associated T-Cell Lymphoma	1.4%
476	Primary Effusion Lymphoma	1.4%
477	Mycosis Fungoides	1.3%
478	Lymphomatoid Papulosis	1.3%
479	Plasmablastic lymphoma	1.3%
480	Lymphomatoid Granulomatosis	1.2%
481	Burkitt Lymphoma	1.1%

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