MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Blepharophimosis

(UMLS:C0005744)

Definition:: The abnormal narrowness of the palpebral fissure in the horizontal direction caused by the lateral displacement of the medial canthi of the eyelids. (Dorland, 27th ed)
UMLS ID:: C0005744
MeSH ID:: D016569

Classification 1:

Name:

Eye Diseases
MeSH Tree Number(s):: C11.250.090|C11.338.190

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.384.190

Synonym(s)

Blepharophimosis

Decreased width of palpebral fissure

Narrow opening between the eyelids

blepharophimosis

blepharophimosis was observed

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Valproic Acid	FAERS: 2		US FAERS
2	Bimatoprost	FAERS: 1		US FAERS
3	Buprenorphine			OFFSIDES
4	Cyclophosphamide		10482872	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Retinal Dysplasia	41.7%
2	Anophthalmos	41.7%
3	Microphthalmos	41.7%
4	Aniridia	39.7%
5	Blepharitis	28.1%
6	Blepharoptosis	28.1%
7	Blepharospasm	28.1%
8	Ectropion	28.1%
9	Entropion	28.1%
10	Trichiasis	28.1%
11	Eyelid Neoplasms	27.7%
12	Retinal Degeneration	22.5%
13	Asthenopia	21.8%
14	Conjunctival Diseases	21.8%
15	Corneal Diseases	21.8%
16	Lacrimal Apparatus Diseases	21.8%
17	Lens Diseases	21.8%
18	Ocular Hypertension	21.8%
19	Ocular Hypotension	21.8%
20	Retinal Diseases	21.8%
21	Scleral Diseases	21.8%
22	Vitreous Detachment	21.8%
23	Posterior Vitreous Detachment	21.8%
24	Hordeolum	21.5%
25	Xerophthalmia	19.4%
26	Low Tension Glaucoma	19.4%
27	Iridocorneal endothelial syndrome	19.4%
28	Aicardi's syndrome	19.4%
29	Uveal Neoplasms	18.6%
30	Retinal Hemorrhage	18.5%
31	Keratoconjunctivitis Sicca	18%
32	Duane Retraction Syndrome	17.8%
33	Eye Infection	17.4%
34	Eye Manifestations	17.4%
35	Eye Neoplasms	17.4%
36	Optic Neuropathy	17.4%
37	CHARGE Syndrome	17.2%
38	Retinitis Pigmentosa	17.1%
39	Pigmentary retinopathy	17.1%
40	Chorioretinitis	17.1%
41	Keratoconjunctivitis	16.4%
42	Corneal Ulcer	16.1%
43	Choroid Hemorrhage	16%
44	Beckwith-Wiedemann Syndrome	15.9%
45	Wolf-Hirschhorn Syndrome	15.9%
46	Pars Planitis	15.9%
47	Abnormalities, Drug-Induced	15.8%
48	Situs Inversus	15.8%
49	Corneal Scar	15.6%
50	Holoprosencephaly	15.4%
51	Ocular Motility Disorders	14.5%
52	Cyclophoria	14.5%
53	Pupil Disorders	14.3%
54	Choroiditis	14.2%
55	Iridocyclitis	14.2%
56	Iritis	14.2%
57	Eye Hemorrhage	14.1%
58	Angioid Streaks	14%
59	Anisometropia	14%
60	Aphakia	14%
61	Astigmatism	14%
62	Choroid Diseases	14%
63	Conjunctivitis	14%
64	Corneal edema	14%
65	Corneal Opacity	14%
66	Dacryocystitis	14%
67	Dry Eye Syndromes	14%
68	Enophthalmos	14%
69	Episcleritis	14%
70	Exophthalmos	14%
71	Glaucoma	14%
72	Iris Diseases	14%
73	Keratitis	14%
74	Keratoconus	14%
75	Lacrimal Duct Obstruction	14%
76	Lens dislocation	14%
77	Lens Subluxation	14%
78	Mydriasis	14%
79	Myopia	14%
80	Presbyopia	14%
81	Pterygium	14%
82	Retinal Detachment	14%
83	Retinitis	14%
84	Scleritis	14%
85	Uveitis	14%
86	Vision Disorders	14%
87	Corneal Neovascularization	14%
88	Orbital Pseudotumor	14%
89	Cataract	14%
90	Pinguecula	14%
91	Metamorphopsia	14%
92	Visual Impairment	14%
93	Eye Injuries	14%
94	Retinopathy of Prematurity	13.9%
95	Smith-Magenis syndrome	13.7%
96	Color blindness	13.6%
97	Cri-du-Chat Syndrome	13.5%
98	Down Syndrome	13.5%
99	Trisomy 21	13.5%
100	Retinoblastoma	13.4%
101	Trachoma	13.3%
102	Cardiovascular Abnormalities	13%
103	Skin Abnormalities	12.7%
104	Lymphatic Abnormalities	12.7%
105	Congenital Microtia	12.7%
106	Congenital diaphragmatic hernia	12.4%
107	Rubinstein-Taybi Syndrome	12.4%
108	Anencephaly	11.9%
109	Ectodermal Dysplasia	11.9%
110	Aplasia Cutis Congenita	11.9%
111	Acanthamoeba Keratitis	11.8%
112	Prader-Willi Syndrome	11.8%
113	Keratitis, Herpetic	11.7%
114	Cytomegalovirus Retinitis	11.7%
115	Bacterial conjunctivitis	11.6%
116	Corneal Perforation	11.5%
117	Endophthalmitis	11.1%
118	Optic Atrophy	11.1%
119	Optic Neuritis	11.1%
120	Papilledema	11.1%
121	Pemphigoid, Benign Mucous Membrane	11.1%
122	Retinal Artery Occlusion	11.1%
123	Strabismus	11.1%
124	Tolosa-Hunt Syndrome	11.1%
125	Orbital Cellulitis	11.1%
126	Retinal Vasculitis	11.1%
127	Hypertensive Retinopathy	11.1%
128	Retrobulbar Hemorrhage	11.1%
129	Corneal Endothelial Cell Loss	11.1%
130	Hyphema	11%
131	Retinal Neovascularization	11%
132	Vitreous Hemorrhage	11%
133	Alstrom Syndrome	11%
134	Eyelid Diseases	10.9%
135	Urogenital Abnormalities	10.8%
136	Angle Closure Glaucoma	10.3%
137	Glaucoma, Open-Angle	10.3%
138	Macular degeneration	10.3%
139	Panuveitis	10.3%
140	Prune Belly Syndrome	10.3%
141	Retinal Drusen	10.3%
142	Retinal Necrosis Syndrome, Acute	10.3%
143	Twins, Conjoined	10.3%
144	Retinoschisis	10.3%
145	Exfoliation Syndrome	10.3%
146	Waardenburg Syndrome	10.3%
147	Congenital nystagmus	10.3%
148	Maxillofacial Abnormalities	10.2%
149	Dural Arteriovenous Fistula	10.2%
150	Dextrocardia	10.1%
151	Kartagener Syndrome	10.1%
152	Panophthalmitis	9.9%
153	Ophthalmia Neonatorum	9.6%
154	Blepharophimosis	9.3%
155	Optic Neuropathy, Ischemic	9.3%
156	Anterior Ischemic Optic Neuropathy	9.3%
157	Optic Atrophy, Hereditary, Leber	9.3%
158	Mandibulofacial Dysostosis	9.3%
159	Retinal Vein Occlusion	9.2%
160	Marfan Syndrome	9.2%
161	Anisocoria	9.1%
162	Diabetic Retinopathy	9.1%
163	Tonic Pupil	9.1%
164	Eye pain	9.1%
165	Orbital Myositis	9.1%
166	Albinism	9.1%
167	Genetic Diseases, Inborn	9.1%
168	Diplopia	9.1%
169	Scotoma	9.1%
170	Photophobia	9.1%
171	Amaurosis	9.1%
172	Blindness	9.1%
173	Nail-Patella Syndrome	8.9%
174	Xeroderma	8.8%
175	Mobius Syndrome	8.8%
176	Eye Abnormalities	8.7%
177	Anterior uveitis	8.5%
178	Uveitis, Posterior	8.5%
179	Anus, Imperforate	8.3%
180	Hydranencephaly	8.3%
181	Neural Tube Defects	8.3%
182	Tethered Cord Syndrome	8.3%
183	Iniencephaly	8.3%
184	Craniorachischisis	8.3%
185	Limb Deformities, Congenital	8.3%
186	Exencephaly	8.3%
187	Septo-Optic Dysplasia	8.3%
188	Craniofacial Abnormalities	8.3%
189	Cortical Dysplasia	8.3%
190	Malformations of Cortical Development	8.3%
191	Anorectal Malformations	8.3%
192	Bloom Syndrome	8.2%
193	Esotropia	8.2%
194	Exotropia	8.2%
195	Choroidal Neovascularization	8.2%
196	Scimitar Syndrome	8%
197	Microcephaly	7.9%
198	Macrocephaly	7.9%
199	Ophthalmoplegia	7.8%
200	External Ophthalmoplegia	7.8%
201	Amblyopia	7.7%
202	Polycystic Kidney Diseases	7.7%
203	Williams Syndrome	7.7%
204	Abnormalities, Radiation-Induced	7.6%
205	Craniosynostosis	7.5%
206	Syndactyly	7.5%
207	Brachycephaly	7.5%
208	Acrocephalosyndactylia	7.5%
209	Cockayne Syndrome	7.5%
210	Fragile X Syndrome	7.5%
211	Fetal Diseases	7.2%
212	Porencephaly	7.1%
213	Classical Lissencephalies and Subcortical Band Heterotopias	7.1%
214	Laryngostenosis	7%
215	Mouth Abnormalities	7%
216	Turner Syndrome	6.9%
217	Esophageal Atresia	6.9%
218	Intestinal Atresia	6.9%
219	Uveomeningoencephalitic Syndrome	6.9%
220	Horseshoe Kidney	6.9%
221	Pectus excavatum	6.9%
222	Klippel-Feil Syndrome	6.9%
223	Gastroschisis	6.9%
224	Synostosis	6.9%
225	Herpes Zoster Ophthalmicus	6.8%
226	Acrodermatitis	6.8%
227	Lymphangiectasis, Intestinal	6.8%
228	Gianotti-Crosti Syndrome	6.8%
229	Epidermolysis Bullosa	6.8%
230	Noonan Syndrome	6.8%
231	Hemianopsia	6.7%
232	Amaurosis Fugax	6.7%
233	Blindness, Cortical	6.7%
234	Primary Ciliary Dyskinesia	6.7%
235	Ichthyosis, X-Linked	6.6%
236	Smith-Lemli-Opitz Syndrome	6.6%
237	Cleft Palate	6.4%
238	Jaw Abnormalities	6.2%
239	Poland Syndrome	6.2%
240	Amelia	6.1%
241	Arachnodactyly	6.1%
242	Ectopia Cordis	6.1%
243	Ectromelia	6.1%
244	Hemimelia	6.1%
245	Meningomyelocele	6.1%
246	Phocomelia	6.1%
247	Sirenomelia	6.1%
248	Spina Bifida	6.1%
249	Polydactyly	6.1%
250	Brachydactyly	6.1%
251	Plagiocephaly	6.1%
252	Lower Extremity Deformities, Congenital	6.1%
253	Upper Extremity Deformities, Congenital	6.1%
254	Single umbilical artery	6.1%
255	Cystic Fibrosis	6.1%
256	Arthrogryposis	6%
257	Choanal Atresia	6%
258	Tracheobronchomegaly	6%
259	Laryngocele	6%
260	Choledochal Cyst	5.9%
261	Hermaphroditism	5.9%
262	Disorders of Sex Development	5.9%
263	Cryptorchidism	5.9%
264	Graves Disease	5.9%
265	Hypospadias	5.9%
266	Central Nervous System Cysts	5.9%
267	Dandy-Walker Syndrome	5.8%
268	Horner Syndrome	5.8%
269	POEMS Syndrome	5.8%
270	Klinefelter Syndrome	5.8%
271	Polycystic Kidney, Autosomal Dominant	5.7%
272	Pseudoxanthoma Elasticum	5.4%
273	Opsoclonus-Myoclonus Syndrome	5.4%
274	Sjogren-Larsson Syndrome	5.4%
275	Abdominal Cramps	5.3%
276	Amniotic Band Syndrome	5.3%
277	Asphyxia Neonatorum	5.3%
278	Infant, Premature, Diseases	5.3%
279	Infantile Colic	5.3%
280	Micrognathism	5.2%
281	Pierre Robin Syndrome	5.2%
282	Meconium Aspiration Syndrome	5.2%
283	Laryngomalacia	5.2%
284	Pectus carinatum	5.2%
285	Bladder Exstrophy	5.1%
286	Epispadias	5.1%
287	Aortic coarctation	5.1%
288	Cor Triatriatum	5.1%
289	Coronary Vessel Anomalies	5.1%
290	Dental Enamel Hypoplasia	5.1%
291	Patent ductus arteriosus	5.1%
292	Ebstein Anomaly	5.1%
293	Heart Septal Defects	5.1%
294	Hypodontia	5.1%
295	Macrostomia	5.1%
296	Meningocele	5.1%
297	Microstomia	5.1%
298	Tetralogy of Fallot	5.1%
299	Transposition of Great Vessels	5.1%
300	Hypoplastic Left Heart Syndrome	5.1%
301	May-Thurner Syndrome	5.1%
302	Encephalocele	5.1%
303	Multicystic Dysplastic Kidney	5.1%
304	Craniofacial Dysostosis	5.1%
305	Dermal Sinus	5.1%
306	Spina Bifida Cystica	5.1%
307	Spina Bifida Occulta	5.1%
308	Lissencephaly	5.1%
309	Polymicrogyria	5.1%
310	Pachygyria	5.1%
311	Schizencephaly	5.1%
312	Periventricular Nodular Heterotopia	5.1%
313	Wolff-Parkinson-White Syndrome	5%
314	Kallmann Syndrome	5%
315	Charcot-Marie-Tooth Disease	5%
316	Antley-Bixler Syndrome Phenotype	5%
317	Xeroderma Pigmentosum	4.9%
318	Hyperkeratosis, Epidermolytic	4.9%
319	Behcet Syndrome	4.9%
320	Miller Fisher Syndrome	4.8%
321	Kearns-Sayre syndrome	4.8%
322	Retrognathia	4.7%
323	Zellweger Syndrome	4.6%
324	Hyperandrogenism	4.5%
325	Sicca Syndrome	4.5%
326	Sjogren's Syndrome	4.5%
327	Basal Cell Nevus Syndrome	4.4%
328	Tuberous Sclerosis	4.4%
329	Long QT Syndrome	4.3%
330	Neoplastic Syndromes, Hereditary	4.3%
331	Platybasia	4.3%
332	Tricuspid Atresia	4.3%
333	Arrhythmogenic Right Ventricular Dysplasia	4.3%
334	Gonadal Dysgenesis	4.3%
335	Bronchomalacia	4.3%
336	Adrenogenital Syndrome	4.3%
337	Tracheomalacia	4.3%
338	Ovotesticular Disorders of Sex Development	4.3%
339	Prognathism	4.3%
340	Refsum Disease	4.2%
341	Aortopulmonary Septal Defect	4.2%
342	Double Outlet Right Ventricle	4.2%
343	Endocardial Cushion Defects	4.2%
344	Myocardial bridging	4.2%
345	Aorticopulmonary Septal Defect	4.2%
346	Anemia, Neonatal	4.2%
347	Multiple Epiphyseal Dysplasia	4.2%
348	Osteochondrodysplasias	4.2%
349	Pelger-Huet Anomaly	4.2%
350	Persistent Fetal Circulation Syndrome	4.2%
351	Werner Syndrome	4.2%
352	Myasthenic Syndromes, Congenital	4.2%
353	Umbilical hernia	4.1%
354	Ophthalmoplegic Migraine	4%
355	Progressive supranuclear palsy	4%
356	Anemia, Sickle Cell	3.9%
357	Thalassemia	3.9%
358	Muscular Dystrophy, Duchenne	3.8%
359	Truncus Arteriosus, Persistent	3.7%
360	Goldenhar Syndrome	3.7%
361	Neuromyelitis Optica	3.6%
362	Dwarfism	3.6%
363	Romano-Ward Syndrome	3.6%
364	Neonatal Abstinence Syndrome	3.5%
365	Fetal Growth Retardation	3.4%
366	Familial Mediterranean Fever	3.4%
367	Muscular Dystrophy	3.4%
368	Osteogenesis Imperfecta	3.4%
369	Fetal Hypoxia	3.4%
370	Fetal Alcohol Spectrum Disorders	3.4%
371	Toxoplasmosis, Congenital	3.4%
372	Syphilis, Congenital	3.4%
373	Rett Syndrome	3.3%
374	Mucopolysaccharidosis II	3.3%
375	Talipes	3.2%
376	Menkes Kinky Hair Syndrome	3%
377	Congenital clubfoot	3%
378	Vertical Talus	3%
379	Optic Nerve Glioma	3%
380	Wiskott-Aldrich Syndrome	3%
381	Autoimmune Lymphoproliferative Syndrome	3%
382	Congenital Hyperinsulinism	2.9%
383	Chorioamnionitis	2.9%
384	Angioedemas, Hereditary	2.9%
385	Sickle Cell Trait	2.8%
386	Paralysis, Obstetric	2.8%
387	Arteriovenous fistula	2.8%
388	Amino Acid Metabolism, Inborn Errors	2.7%
389	Carbohydrate Metabolism, Inborn Errors	2.7%
390	Metal Metabolism, Inborn Errors	2.7%
391	Progeria	2.7%
392	Lysosomal Storage Diseases	2.7%
393	Cytochrome-c Oxidase Deficiency	2.7%
394	Peroxisomal Disorders	2.7%
395	Bronchopulmonary Dysplasia	2.7%
396	Neuronal Ceroid-Lipofuscinoses	2.7%
397	Myotonic Dystrophy	2.7%
398	Adrenoleukodystrophy	2.5%
399	Hepatolenticular Degeneration	2.4%
400	Respiratory Distress Syndrome, Newborn	2.3%
401	Amyloid Neuropathies, Familial	2.3%
402	Fabry Disease	2.3%
403	Cutis Laxa	2.3%
404	Denys-Drash Syndrome	2.3%
405	Porokeratosis	2.3%
406	Keratoderma, Palmoplantar	2.3%
407	Chronic granulomatous disease	2.3%
408	Acute Chest Syndrome	2.2%
409	Welander Distal Myopathy	2.2%
410	Glycogen storage disease type II	2.2%
411	Galactosemias	2.2%
412	Urea Cycle Disorders, Inborn	2.2%
413	Tyrosinemias	2.2%
414	Hydrops Fetalis	2.2%
415	Mucopolysaccharidosis III	2.1%
416	Ataxia Telangiectasia	2%
417	Alkaptonuria	2%
418	Glycogen Storage Disease	2%
419	Hypophosphatasia	2%
420	Propionic acidemia	2%
421	Dihydropyrimidine Dehydrogenase Deficiency	2%
422	Cystinosis	2%
423	Hyperphosphaturia	2%
424	Porphyrias, Hepatic	2%
425	Canavan Disease	1.9%
426	Alexander Disease	1.9%
427	Peutz-Jeghers Syndrome	1.9%
428	Myotonia Congenita	1.9%
429	Thrombasthenia	1.9%
430	Antithrombin III Deficiency	1.9%
431	Protein C Deficiency	1.9%
432	Brain Diseases, Metabolic, Inborn	1.9%
433	Afibrinogenemia	1.9%
434	Dystonia Musculorum Deformans	1.9%
435	Factor VII Deficiency	1.9%
436	Factor X Deficiency	1.9%
437	Factor XII Deficiency	1.9%
438	Hemophilia A	1.9%
439	Leukomalacia, Periventricular	1.9%
440	Activated Protein C Resistance	1.9%
441	Factor II deficiency	1.9%
442	Factor VIII Deficiency	1.9%
443	Factor V deficiency	1.9%
444	Factor XI Deficiency	1.9%
445	Hypoprothrombinemias	1.9%
446	Fanconi Anemia	1.9%
447	Nesidioblastosis	1.9%
448	Lafora Disease	1.9%
449	Unverricht-Lundborg Syndrome	1.9%
450	Anemia, Diamond-Blackfan	1.9%
451	Homocystinuria	1.8%
452	Gaucher Disease	1.8%
453	Leigh Disease	1.8%
454	Multiple Endocrine Neoplasia	1.7%
455	Congenital Hypothyroidism	1.7%
456	Dermatitis, Atopic	1.7%
457	Hyaline Membrane Disease	1.7%
458	Glycogen Storage Disease Type I	1.7%
459	Glycogen Storage Disease Type V	1.7%
460	Hypolipoproteinemias	1.7%
461	Papillon-Lefevre Disease	1.7%
462	Hyperlipidemia, Familial Combined	1.7%
463	Hyperlipoproteinemia Type III	1.7%
464	Tay-Sachs Disease	1.7%
465	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.6%
466	Niemann-Pick Disease, Type C	1.6%
467	Kernicterus	1.5%
468	Familial Periodic Paralysis	1.5%
469	Lactose Intolerance	1.4%
470	Variegate Porphyria	1.4%
471	Acute intermittent porphyria	1.4%
472	Porphyria Cutanea Tarda	1.4%
473	Hyperhomocysteinemia	1.4%
474	Renal Aminoacidurias	1.4%
475	Fanconi Syndrome	1.4%
476	Pseudohypoaldosteronism	1.4%
477	Liddle Syndrome	1.4%
478	Hyperlipoproteinemia Type IV	1.4%
479	Hyperlipoproteinemia Type V	1.4%
480	Hypoalphalipoproteinemias	1.4%
481	Huntington Disease	1.3%
482	Gout	1.3%
483	Multiple Endocrine Neoplasia Type 1	1.3%
484	Pseudohypoparathyroidism	1.3%
485	Friedreich Ataxia	1.2%
486	Renal tubular acidosis	1.2%
487	Nephroblastoma	1.2%
488	Hypokalemic periodic paralysis	1.2%
489	Cystinuria	1.2%
490	Adenomatous Polyposis Coli	1.1%
491	Familial Hypophosphatemic Rickets	1.1%
492	Arthritis, Gouty	1%
493	Glycosuria, Renal	1%
494	MELAS Syndrome	0.8%

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