MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Capillary Leak Syndrome

(UMLS:C0343084)

Definition:: A condition characterized by recurring episodes of fluid leaking from capillaries into extra-vascular compartments causing hematocrit to rise precipitously. If not treated, generalized vascular leak can lead to generalized EDEMA; SHOCK; cardiovascular collapse; and MULTIPLE ORGAN FAILURE.
UMLS ID:: C0343084
MeSH ID:: D019559

Classification:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.907.218

Synonym(s)

Capillary Leak Syndrome

Acute Vascular Leak Syndrome

Capillary leak syndrome

Systemic capillary leak syndrome

capillary leak syndrome

capillary leaking syndrome

systemic capillary leak syndrome

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	gemcitabine	FAERS: 43		US FAERS
2	Docetaxel	FAERS: 21		OFFSIDES US FAERS
3	Bortezomib	FAERS: 12	20150504	CTD OFFSIDES US FAERS
4	Clofarabine	FAERS: 9	20057324	CTD OFFSIDES SIDER US FAERS
5	Amlodipine	FAERS: 6		US FAERS
6	gemcitabine	FAERS: 5	View details 11822767 16477934 18176375 20148474	CTD SIDER US FAERS
7	Acitretin	FAERS: 3	14746632 17097361	CTD OFFSIDES SIDER US FAERS
8	Allopurinol	FAERS: 3		US FAERS
9	Imatinib Mesylate	FAERS: 3		US FAERS
10	Levofloxacin	FAERS: 3		US FAERS
11	Methylprednisolone	FAERS: 3		US FAERS
12	Micafungin	FAERS: 3		US FAERS
13	Pemetrexed	FAERS: 3		US FAERS
14	Voriconazole	FAERS: 3		OFFSIDES US FAERS
15	Amlodipine	FAERS: 2		US FAERS
16	Bendamustine Hydrochloride	FAERS: 2		US FAERS
17	Dasatinib	FAERS: 2		US FAERS
18	Everolimus	FAERS: 2		US FAERS
19	Metformin	FAERS: 2		US FAERS
20	Pregabalin	FAERS: 2		US FAERS
21	Sorafenib	FAERS: 2		US FAERS
22	Sunitinib	FAERS: 2		US FAERS
23	Trabectedin	FAERS: 2		US FAERS
24	eribulin	FAERS: 2		US FAERS
25	Arthrotec	FAERS: 1		US FAERS
26	Avalide	FAERS: 1		US FAERS
27	Baclofen	FAERS: 1		US FAERS
28	Bosentan	FAERS: 1		US FAERS
29	Busulfan	FAERS: 1		OFFSIDES SIDER US FAERS
30	Cladribine	FAERS: 1		US FAERS
31	Cyclosporine	FAERS: 1		OFFSIDES US FAERS
32	Cytarabine	FAERS: 1		OFFSIDES SIDER US FAERS
33	Dexrazoxane	FAERS: 1		US FAERS
34	Fulvestrant	FAERS: 1		US FAERS
35	GDC-0973	FAERS: 1		US FAERS
36	Hydrocortisone	FAERS: 1		OFFSIDES US FAERS
37	Imiquimod	FAERS: 1		SIDER US FAERS
38	Losartan	FAERS: 1		US FAERS
39	Metformin	FAERS: 1		US FAERS
40	Paclitaxel	FAERS: 1		OFFSIDES US FAERS
41	Piroxicam	FAERS: 1	14682198	CTD OFFSIDES US FAERS
42	Progesterone	FAERS: 1		US FAERS
43	Ramipril	FAERS: 1		US FAERS
44	Rivaroxaban	FAERS: 1		US FAERS
45	Sitagliptin Phosphate	FAERS: 1		US FAERS
46	Temozolomide	FAERS: 1		US FAERS
47	Tretinoin	FAERS: 1		US FAERS
48	Triptorelin Pamoate	FAERS: 1		US FAERS
49	bosutinib	FAERS: 1		US FAERS
50	cabozantinib	FAERS: 1		US FAERS
51	carfilzomib	FAERS: 1		US FAERS
52	gadobutrol	FAERS: 1		US FAERS
53	ixabepilone	FAERS: 1		US FAERS
54	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride			OFFSIDES
55	Amikacin			OFFSIDES
56	Aminophylline		9428835 11713377	CTD
57	Ampicillin			OFFSIDES
58	Arsenicals			SIDER
59	Aspirin			OFFSIDES
60	Bendamustine Hydrochloride			OFFSIDES
61	Bupropion			OFFSIDES
62	Calcium Carbonate			OFFSIDES
63	Carbimazole			OFFSIDES
64	Caspofungin			OFFSIDES
65	Caspofungin			OFFSIDES
66	Cefotaxime			OFFSIDES
67	Cefuroxime			OFFSIDES
68	Celecoxib			OFFSIDES
69	Chlorhexidine			OFFSIDES
70	Chlorothiazide			OFFSIDES
71	Clotrimazole			OFFSIDES
72	Cyclizine			OFFSIDES
73	Cyclophosphamide			OFFSIDES
74	D-Galactosamine			OFFSIDES
75	Dapsone			OFFSIDES
76	Dexamethasone		20150504	CTD OFFSIDES
77	Doxorubicin		20104463	CTD
78	Epinephrine			OFFSIDES
79	Ethylene Glycol			OFFSIDES
80	Etoposide			OFFSIDES
81	Famciclovir			OFFSIDES
82	Famotidine			OFFSIDES
83	Fluticasone-Salmeterol Drug Combination			OFFSIDES
84	Furosemide			OFFSIDES
85	Galactose			OFFSIDES
86	Ganciclovir			OFFSIDES
87	Glutamine			OFFSIDES
88	Ifosfamide			SIDER
89	Imipenem			OFFSIDES
90	Isradipine			OFFSIDES
91	Ketamine			OFFSIDES
92	Lactulose			OFFSIDES
93	Letrozole			OFFSIDES
94	Leucovorin			OFFSIDES
95	Linezolid			OFFSIDES
96	Lisinopril			OFFSIDES
97	Loratadine			OFFSIDES
98	Lorazepam			OFFSIDES
99	Mesna			OFFSIDES
100	Methotrexate			OFFSIDES
101	Miconazole			OFFSIDES
102	Nebivolol			OFFSIDES
103	Niacin			OFFSIDES
104	Nicorandil			OFFSIDES
105	Nitric Oxide			OFFSIDES
106	Nystatin			OFFSIDES
107	Ofloxacin			OFFSIDES
108	Ondansetron			OFFSIDES
109	Pamidronate			OFFSIDES
110	Piperacillin			OFFSIDES
111	Pirinitramide			OFFSIDES
112	Polylysine			OFFSIDES
113	Prednisone acetate			OFFSIDES
114	Prednisone			OFFSIDES
115	Sirolimus		10328196	CTD
116	Sodium Bicarbonate			OFFSIDES
117	Terbutaline		9428835 11713377	CTD
118	Thiotepa			OFFSIDES
119	Tobramycin			OFFSIDES
120	Tolterodine Tartrate			OFFSIDES
121	Tremorine			OFFSIDES
122	Trimetazidine			OFFSIDES
123	Trimipramine			OFFSIDES
124	Vancomycin			OFFSIDES
125	Vincristine			OFFSIDES
126	Vinorelbine			OFFSIDES
127	benazepril			OFFSIDES
128	chlorhexidine gluconate			OFFSIDES
129	fenoterol, ipratropium drug combination			OFFSIDES
130	ferrous gluconate			OFFSIDES
131	fludarabine phosphate			OFFSIDES
132	fludarabine			OFFSIDES
133	moxonidine			OFFSIDES
134	pimecrolimus			OFFSIDES
135	posaconazole			OFFSIDES
136	ropinirole			OFFSIDES
137	turmeric extract		18635243	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Aneurysm	42.9%
2	Angiomatosis	42.9%
3	Aortic Diseases	42.9%
4	Arterial Occlusive Diseases	42.9%
5	Hyperemia	42.9%
6	Hypotension	42.9%
7	Superior Vena Cava Syndrome	42.9%
8	Telangiectasis	42.9%
9	Vasculitis	42.9%
10	Venous Insufficiency	42.9%
11	Peripheral Vascular Diseases	42.9%
12	Embolism and Thrombosis	42.9%
13	Angiodysplasia	42.9%
14	Prehypertension	42.9%
15	Aortic Aneurysm	40.9%
16	Aortitis	40.9%
17	Leriche Syndrome	40.9%
18	Periphlebitis	40.9%
19	Phlebitis	40.9%
20	Thromboangiitis Obliterans	40.9%
21	Myocardial Ischemia	38.1%
22	Postphlebitic Syndrome	37.1%
23	Thrombophlebitis	35.8%
24	Blue Toe Syndrome	34.3%
25	Aortic Aneurysm, Abdominal	33.3%
26	Aortic Aneurysm, Thoracic	33.3%
27	Retinal Vein Occlusion	32.5%
28	Coronary Aneurysm	31.7%
29	Aneurysm, Dissecting	31%
30	Arteriosclerosis	31%
31	Arteritis	31%
32	Embolism	31%
33	Erythromelalgia	31%
34	Fibromuscular Dysplasia	31%
35	Malignant Hypertension	31%
36	Raynaud Disease	31%
37	Thromboembolism	31%
38	Thrombosis	31%
39	Essential Hypertension	31%
40	Aneurysm, Ruptured	31%
41	Iliac Aneurysm	31%
42	Pulmonary artery stenosis	31%
43	White Coat Hypertension	31%
44	Systemic Vasculitis	31%
45	Embolus	31%
46	Malignant Atrophic Papulosis	30.5%
47	Shwartzman Phenomenon	30.3%
48	Aortic Rupture	30.2%
49	Vascular System Injuries	30%
50	Coronary Thrombosis	28.9%
51	Coronary Artery Disease	28.9%
52	Compartment syndromes	28.6%
53	Hepatic Veno-Occlusive Disease	28.6%
54	Peliosis Hepatis	28.6%
55	Varicocele	28.6%
56	Carotid Artery Thrombosis	28.4%
57	Cerebrovascular Disorders	27.9%
58	Diabetic Angiopathies	27.9%
59	Reperfusion Injury	27.9%
60	Splenic Infarction	27.9%
61	Cerebrovascular Insufficiency	27.9%
62	Vascular Neoplasms	27.9%
63	Spinal Cord Vascular Diseases	27.9%
64	Vasoplegia	27.9%
65	Hemorrhoids	27.6%
66	Thoracic Outlet Syndrome	27.6%
67	Intracranial Embolism and Thrombosis	27.5%
68	Carotid Stenosis	27.4%
69	Intracranial Aneurysm	27.4%
70	Coronary heart disease	27.3%
71	Myocardial Infarction	27.3%
72	Acute Coronary Syndrome	27.3%
73	Myocardial Reperfusion Injury	26.8%
74	Arteriosclerosis Obliterans	25.4%
75	Atherosclerosis	25.4%
76	Air Embolism	25.4%
77	Endarteritis	25.4%
78	Venous Thrombosis	25.4%
79	Deep Vein Thrombosis	25.4%
80	Venous Thromboembolism	25.4%
81	Moyamoya Disease	25.3%
82	Polyarteritis Nodosa	25%
83	Takayasu Arteritis	25%
84	Intracranial Arteriosclerosis	24.7%
85	Cerebral Atherosclerosis	24.7%
86	Cerebral Arteriosclerosis	24.7%
87	Cerebral Thrombosis	23.4%
88	Intracranial Embolism	23.4%
89	Intracranial Thrombosis	23.4%
90	Heart Diseases	23.1%
91	Coronary Occlusion	22.2%
92	Microvascular Angina	22.2%
93	Coronary Stenosis	22.2%
94	ST segment elevation myocardial infarction	22.2%
95	Hand-Arm Vibration Syndrome	21.8%
96	Arteriovenous fistula	21.6%
97	Sinus Thrombosis, Intracranial	21.3%
98	Optic Neuropathy, Ischemic	21.1%
99	Anterior Ischemic Optic Neuropathy	21.1%
100	Mesenteric vascular insufficiency	21.1%
101	Retinal Artery Occlusion	20.9%
102	Retinal Vasculitis	20.9%
103	Hypertensive Retinopathy	20.9%
104	Kounis Syndrome	20.7%
105	Anterior Compartment Syndrome	20.5%
106	Vasculitis, Leukocytoclastic, Cutaneous	20.5%
107	Gastric Antral Vascular Ectasia	20.5%
108	Abdominal Compartment Syndrome	20.5%
109	Cavernous Sinus Thrombosis	20.3%
110	Sagittal Sinus Thrombosis	20.3%
111	Angioedema	20.3%
112	Vasculitis, Central Nervous System	20.3%
113	Colitis, Ischemic	20.3%
114	Carotid Artery Diseases	20.2%
115	Brain Ischemia	20.2%
116	Hypotension, Orthostatic	20.2%
117	Cerebrovascular accident	20.2%
118	Varicose Ulcer	20.2%
119	Vasospasm, Intracranial	20.2%
120	Spinal Cord Ischemia	20.2%
121	Intracranial Arterial Diseases	20.2%
122	Primary Graft Dysfunction	20.2%
123	Post-Exercise Hypotension	20.2%
124	May-Thurner Syndrome	20.2%
125	Angina Pectoris	20.1%
126	Coronary Restenosis	19.8%
127	Embolism, Amniotic Fluid	19.7%
128	Brain Infarction	19.6%
129	Lemierre Syndrome	18.9%
130	Giant Cell Arteritis	18.5%
131	Temporal Arteritis	18.5%
132	Infarction, Middle Cerebral Artery	17.8%
133	Infarction, Anterior Cerebral Artery	17.8%
134	Infarction, Posterior Cerebral Artery	17.8%
135	Cerebral Infarction	17.5%
136	Brain Stem Infarctions	17.5%
137	Intermittent Claudication	17.2%
138	Pulmonary Embolism	17.2%
139	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	17.2%
140	Subarachnoid Hemorrhage, Traumatic	17%
141	Carotid Artery, Internal, Dissection	17%
142	No-Reflow Phenomenon	16.9%
143	Shock, Cardiogenic	16.7%
144	Cerebral Arterial Diseases	16.6%
145	Vertebrobasilar Insufficiency	16.6%
146	Anterior Spinal Artery Syndrome	16.6%
147	Basilar Artery Stenosis	16.6%
148	Vertebral Artery Stenosis	16.6%
149	Intracranial Hemorrhage, Hypertensive	16.6%
150	Transient Cerebral Ischemia	16.6%
151	Vertebral Artery Dissection	16.5%
152	Angina, Unstable	16.4%
153	Lateral Medullary Syndrome	16.4%
154	Mesenteric Vascular Occlusion	15.5%
155	Mucocutaneous Lymph Node Syndrome	15.5%
156	CREST Syndrome	15.5%
157	Hepatic Vein Thrombosis	15.4%
158	Budd-Chiari Syndrome	15.4%
159	Diabetic Retinopathy	15.4%
160	Sturge-Weber Syndrome	15.4%
161	Livedo Reticularis	15.3%
162	Renal hypertension	15.1%
163	Renal Artery Obstruction	15.1%
164	Renal Artery Stenosis	15.1%
165	Pulmonary Infarction	15.1%
166	Hemangioma, Cavernous	15%
167	Pregnancy Complications, Cardiovascular	15%
168	Cardiovascular Abnormalities	15%
169	Basal Ganglia Cerebrovascular Disease	15%
170	Vascular Headaches	14.9%
171	Scurvy	14.9%
172	Subclavian Steal Syndrome	14.8%
173	Scimitar Syndrome	14.8%
174	Angina Pectoris, Variant	14.6%
175	Cardiac Tamponade	14.3%
176	Endocarditis	14.3%
177	Cardiac Arrest	14.3%
178	Heart failure	14.3%
179	Pericardial effusion	14.3%
180	Pericarditis	14.3%
181	Pneumopericardium	14.3%
182	Cor pulmonale	14.3%
183	Ventricular Outflow Obstruction	14.3%
184	Ventricular Dysfunction	14.3%
185	Cardiomyopathies	14.3%
186	Pleuropericarditis	14.3%
187	Carotid Artery Injuries	14.1%
188	Aortic Valve Stenosis	13.6%
189	Cardiomyopathy, Dilated	13.6%
190	Pulmonary Valve Stenosis	13.6%
191	Basal Ganglia Hemorrhage	13.1%
192	Hypertension, Renovascular	12.3%
193	Subarachnoid Hemorrhage	12.3%
194	Hypoxia-Ischemia, Brain	12.3%
195	Cerebral Hemorrhage	12.3%
196	Hereditary Angioedema Type III	12.2%
197	Hereditary Angioedema Types I and II	12.2%
198	Ischemic contracture	12.2%
199	Angioedemas, Hereditary	12.1%
200	Tricuspid Atresia	12.1%
201	Arrhythmogenic Right Ventricular Dysplasia	12.1%
202	Putaminal Hemorrhage	12%
203	Cryoglobulinemia	12%
204	Leukomalacia, Periventricular	12%
205	Diabetic Foot	11.9%
206	Hypertrophic Cardiomyopathy	11.7%
207	Hypertrophic obstructive cardiomyopathy	11.7%
208	Granulomatosis with polyangiitis	11.3%
209	Supravalvular aortic stenosis	11.1%
210	Lown-Ganong-Levine Syndrome	11.1%
211	Cerebral Amyloid Angiopathy	11%
212	Dementia, Vascular	11%
213	Aortic Valve Insufficiency	10.3%
214	Restrictive cardiomyopathy	10.3%
215	Endocardial Fibroelastosis	10.3%
216	Heart Rupture, Post-Infarction	10.3%
217	Mitral Valve Insufficiency	10.3%
218	Mitral Valve Stenosis	10.3%
219	Myocarditis	10.3%
220	Pericarditis, Constrictive	10.3%
221	Pulmonary Valve Insufficiency	10.3%
222	Tricuspid Valve Insufficiency	10.3%
223	Tricuspid Valve Stenosis	10.3%
224	Ventricular Dysfunction, Left	10.3%
225	Right Ventricular Dysfunction	10.3%
226	Endomyocardial Fibrosis	10.3%
227	Carditis	10.3%
228	Heart Failure, Systolic	10.3%
229	Heart Failure, Diastolic	10.3%
230	Heart Block	10.2%
231	Tachycardia	10.2%
232	Tachyarrhythmia	10.2%
233	Aortic coarctation	10.1%
234	Cor Triatriatum	10.1%
235	Coronary Vessel Anomalies	10.1%
236	Patent ductus arteriosus	10.1%
237	Ebstein Anomaly	10.1%
238	Heart Septal Defects	10.1%
239	Tetralogy of Fallot	10.1%
240	Transposition of Great Vessels	10.1%
241	Hypoplastic Left Heart Syndrome	10.1%
242	Pituitary Apoplexy	10%
243	Shy-Drager Syndrome	9.9%
244	Purpura, Hyperglobulinemic	9.9%
245	Bacterial Endocarditis	9.7%
246	Cardiac Output, High	9.5%
247	Myocardial Stunning	9.5%
248	Low Cardiac Output Syndrome	9.5%
249	Cardiomegaly	9.3%
250	Postpericardiotomy Syndrome	9.3%
251	Cardiac Hypertrophy	9.3%
252	Rheumatic Heart Disease	9.1%
253	Behcet Syndrome	8.6%
254	Waldenstrom Macroglobulinemia	8.6%
255	Multiple Myeloma	8.6%
256	Aortic Valve Prolapse	8.5%
257	Tricuspid Valve Prolapse	8.5%
258	Takotsubo Cardiomyopathy	8.5%
259	Rheumatoid Vasculitis	8.3%
260	Adams-Stokes Syndrome	8.3%
261	Atrioventricular Block	8.3%
262	Bundle-Branch Block	8.3%
263	Atrial Premature Complexes	8.3%
264	Sinoatrial Block	8.3%
265	Tachycardia, Paroxysmal	8.3%
266	Supraventricular tachycardia	8.3%
267	Tachycardia, Ventricular	8.3%
268	Wolff-Parkinson-White Syndrome	8.3%
269	Tachycardia, Reciprocating	8.3%
270	Aortopulmonary Septal Defect	8.2%
271	Double Outlet Right Ventricle	8.2%
272	Endocardial Cushion Defects	8.2%
273	Myocardial bridging	8.2%
274	Aorticopulmonary Septal Defect	8.2%
275	Sick Sinus Syndrome	8.2%
276	Lupus Vasculitis, Central Nervous System	8.2%
277	Dextrocardia	8.1%
278	Long QT Syndrome	8.1%
279	Ataxia Telangiectasia	7.6%
280	Pseudoxanthoma Elasticum	7.6%
281	Tachycardia, Atrioventricular Nodal Reentry	7.3%
282	Tachycardia, Ectopic Atrial	7.3%
283	Tachycardia, Ectopic Junctional	7.3%
284	Sinus Tachycardia	7.3%
285	Torsades de Pointes	7.3%
286	Accelerated Idioventricular Rhythm	7.3%
287	Truncus Arteriosus, Persistent	7.3%
288	Sinus Arrhythmia	6.8%
289	Atrial Fibrillation	6.8%
290	Atrial Flutter	6.8%
291	Edema, Cardiac	6.8%
292	Ventricular Fibrillation	6.8%
293	Ventricular Flutter	6.8%
294	Parasystole	6.8%
295	Paroxysmal atrial fibrillation	6.8%
296	Bradycardia	6.8%
297	Diabetic Cardiomyopathies	6.8%
298	Cardiomyopathy, Alcoholic	6.7%
299	Ectopia Cordis	6.7%
300	Sudden Cardiac Death	6.7%
301	Left Ventricular Hypertrophy	6.7%
302	Right Ventricular Hypertrophy	6.7%
303	Single umbilical artery	6.7%
304	Chagas Cardiomyopathy	6.7%
305	Romano-Ward Syndrome	6.6%
306	Hematoma, Subdural	6.3%
307	Hematoma, Epidural, Cranial	6.3%
308	Subacute Bacterial Endocarditis	6.1%
309	Hematoma, Subdural, Intracranial	5.9%
310	Hematoma, Subdural, Chronic	5.9%
311	Hematoma, Subdural, Acute	5.9%
312	Noonan Syndrome	5.8%
313	Sinus Arrest, Cardiac	5.6%
314	Brain Hemorrhage, Traumatic	5.5%
315	Carcinoid Heart Disease	5.3%
316	Marfan Syndrome	5.1%
317	Dyspnea, Paroxysmal	5%
318	MELAS Syndrome	4.9%
319	Dural Arteriovenous Fistula	4.1%
320	Fabry Disease	3.7%
321	Williams Syndrome	3%
322	Turner Syndrome	2.8%
323	Kartagener Syndrome	2.6%
324	Kearns-Sayre syndrome	1.8%

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