MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Rubinstein-Taybi Syndrome

(UMLS:C0035934)

Definition:: A chromosomal disorder characterized by MENTAL RETARDATION, broad thumbs, webbing of fingers and toes, beaked nose, short upper lip, pouting lower lip, agenesis of corpus callosum, large foramen magnum, keloid formation, pulmonary stenosis, vertebral anomalies, chest wall anomalies, sleep apnea, and megacolon. The disease has an autosomal dominant pattern of inheritance and is associated with deletions of the short arm of chromosome 16 (16p13.3).
UMLS ID:: C0035934
MeSH ID:: D012415

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.099.370.797|C05.660.207.850

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.597.606.360.700

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.077.804|C16.131.260.790|C16.131.621.207.850|C16.320.180.790

Synonym(s)

Rubinstein-Taybi Syndrome

Rubenstein-Taybi syndrome

Rubinstein syndrome

Rubinstein-Taybi

Rubinstein-Taybi syndrome

Rubinstein-Taybi syndrome (RSTS, RTS)

broad thumb-hallux syndrome

broad thumb-mental retardation syndrome

rubenstein taybi syndrome

10.

rubenstein-taybi syndrome

11.

rubinstein syndrome

12.

rubinstein taybi syndrome

13.

rubinstein taybis syndrome

14.

rubinstein-taybi syndrome

15.

syndrome rubinstein taybi

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Sertraline	FAERS: 6		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Holoprosencephaly	60.5%
2	Cri-du-Chat Syndrome	52.4%
3	Down Syndrome	52.4%
4	Trisomy 21	52.4%
5	Prader-Willi Syndrome	47.9%
6	Beckwith-Wiedemann Syndrome	47.9%
7	Wolf-Hirschhorn Syndrome	47.9%
8	Smith-Magenis syndrome	45.3%
9	Craniosynostosis	42.8%
10	Brachycephaly	42.8%
11	Acrocephalosyndactylia	42.2%
12	Craniofacial Dysostosis	37.7%
13	Williams Syndrome	36.4%
14	Platybasia	35.9%
15	Maxillofacial Abnormalities	35.8%
16	Klippel-Feil Syndrome	34.8%
17	Synostosis	34.8%
18	Syndactyly	34.1%
19	Aicardi's syndrome	34.1%
20	Fragile X Syndrome	33.8%
21	Marfan Syndrome	33.3%
22	Pectus excavatum	32.2%
23	Microcephaly	31.5%
24	Macrocephaly	31.5%
25	Ectodermal Dysplasia	31.1%
26	Aplasia Cutis Congenita	31.1%
27	Cockayne Syndrome	30.2%
28	Nail-Patella Syndrome	30.1%
29	Pectus carinatum	30.1%
30	Plagiocephaly	29.9%
31	Kartagener Syndrome	29.7%
32	CHARGE Syndrome	29.2%
33	Arthrogryposis	28.7%
34	Noonan Syndrome	27.7%
35	Poland Syndrome	26.8%
36	Limb Deformities, Congenital	26.6%
37	Alstrom Syndrome	26.5%
38	Mandibulofacial Dysostosis	26.1%
39	Porencephaly	25.7%
40	Jaw Abnormalities	25.7%
41	Antley-Bixler Syndrome Phenotype	25%
42	Goldenhar Syndrome	24.2%
43	Mobius Syndrome	23.9%
44	Gastroschisis	23.8%
45	Abnormalities, Drug-Induced	23.7%
46	Situs Inversus	23.7%
47	Polycystic Kidney Diseases	22.7%
48	Cleft Palate	22.4%
49	Multiple Epiphyseal Dysplasia	22.1%
50	Osteochondrodysplasias	22.1%
51	Anencephaly	22%
52	Smith-Lemli-Opitz Syndrome	21.9%
53	Prune Belly Syndrome	21.8%
54	Waardenburg Syndrome	21.8%
55	Basal Cell Nevus Syndrome	21.7%
56	Ichthyosis, X-Linked	21.5%
57	Eye Abnormalities	21.5%
58	Cardiovascular Abnormalities	21.5%
59	Skin Abnormalities	21.2%
60	Lymphatic Abnormalities	21.2%
61	Congenital Microtia	21.2%
62	Congenital diaphragmatic hernia	21%
63	Dural Arteriovenous Fistula	20.8%
64	Micrognathism	20.7%
65	Pierre Robin Syndrome	20.7%
66	Rubinstein-Taybi Syndrome	20.7%
67	Turner Syndrome	20.6%
68	Dwarfism	20.3%
69	Prognathism	19.5%
70	Urogenital Abnormalities	19.5%
71	Bloom Syndrome	19.4%
72	Primary Ciliary Dyskinesia	19.3%
73	Retrognathia	19.2%
74	Dextrocardia	19.2%
75	Rett Syndrome	18.4%
76	Amelia	18.2%
77	Arachnodactyly	18.2%
78	Ectromelia	18.2%
79	Hemimelia	18.2%
80	Phocomelia	18.2%
81	Sirenomelia	18.2%
82	Polydactyly	18.2%
83	Brachydactyly	18.2%
84	Lower Extremity Deformities, Congenital	18.2%
85	Upper Extremity Deformities, Congenital	18.2%
86	Mucopolysaccharidosis II	18.2%
87	Xeroderma	18.1%
88	Klinefelter Syndrome	18.1%
89	Cystic Fibrosis	17.8%
90	Menkes Kinky Hair Syndrome	17.6%
91	Osteogenesis Imperfecta	17.2%
92	Zellweger Syndrome	17.1%
93	Retinal Dysplasia	16.8%
94	Laryngomalacia	16.8%
95	Classical Lissencephalies and Subcortical Band Heterotopias	16.8%
96	Aniridia	16.7%
97	Polycystic Kidney, Autosomal Dominant	16.6%
98	Epidermolysis Bullosa	16.5%
99	Scimitar Syndrome	16.5%
100	POEMS Syndrome	16.4%
101	Tuberous Sclerosis	16.3%
102	Sjogren-Larsson Syndrome	16.1%
103	Adrenoleukodystrophy	15.7%
104	Abnormalities, Radiation-Induced	15.7%
105	Muscular Dystrophy, Duchenne	15.6%
106	Refsum Disease	15.5%
107	Hydranencephaly	15.5%
108	Neural Tube Defects	15.5%
109	Tethered Cord Syndrome	15.5%
110	Iniencephaly	15.5%
111	Craniorachischisis	15.5%
112	Exencephaly	15.5%
113	Septo-Optic Dysplasia	15.5%
114	Cortical Dysplasia	15.5%
115	Malformations of Cortical Development	15.5%
116	Twins, Conjoined	15.2%
117	Myotonic Dystrophy	15.1%
118	Albinism	14.9%
119	Fetal Diseases	14.7%
120	Congenital Hypothyroidism	14.6%
121	Muscular Dystrophy	14.6%
122	Kallmann Syndrome	14.4%
123	Pseudoxanthoma Elasticum	14.2%
124	Talipes	14.1%
125	Myasthenic Syndromes, Congenital	14%
126	Dandy-Walker Syndrome	13.8%
127	Anemia, Sickle Cell	13.8%
128	Thalassemia	13.8%
129	Charcot-Marie-Tooth Disease	13.7%
130	Anophthalmos	13.7%
131	Anus, Imperforate	13.7%
132	Microphthalmos	13.7%
133	Anorectal Malformations	13.7%
134	Central Nervous System Cysts	13.6%
135	Xeroderma Pigmentosum	13.3%
136	Neoplastic Syndromes, Hereditary	13.2%
137	Pelger-Huet Anomaly	12.9%
138	Werner Syndrome	12.9%
139	Meconium Aspiration Syndrome	12.9%
140	Gigantism	12.5%
141	Bronchomalacia	12.5%
142	Tracheomalacia	12.5%
143	Hyperkeratosis, Epidermolytic	12.5%
144	Blepharophimosis	12.4%
145	Laryngostenosis	12.4%
146	Mouth Abnormalities	12.4%
147	Esophageal Atresia	12.3%
148	Intestinal Atresia	12.3%
149	Horseshoe Kidney	12.3%
150	Genetic Diseases, Inborn	12.2%
151	Acrodermatitis	12.2%
152	Lymphangiectasis, Intestinal	12.2%
153	Gianotti-Crosti Syndrome	12.2%
154	Craniofacial Abnormalities	12.2%
155	Hepatolenticular Degeneration	12.1%
156	Congenital clubfoot	12%
157	Vertical Talus	12%
158	Osteoarthropathy, Secondary Hypertrophic	11.9%
159	Wiskott-Aldrich Syndrome	11.6%
160	Gout	11.6%
161	Choanal Atresia	11.3%
162	Tracheobronchomegaly	11.3%
163	Laryngocele	11.3%
164	Choledochal Cyst	11.2%
165	Hermaphroditism	11.2%
166	Disorders of Sex Development	11.2%
167	Cryptorchidism	11.2%
168	Hypospadias	11.2%
169	Meningomyelocele	10.9%
170	Spina Bifida	10.9%
171	Neuronal Ceroid-Lipofuscinoses	10.9%
172	Osteochondritis	10.7%
173	Ataxia Telangiectasia	10.7%
174	Fabry Disease	10.7%
175	Autoimmune Lymphoproliferative Syndrome	10.6%
176	Amyloid Neuropathies, Familial	10.5%
177	Angioedemas, Hereditary	10.5%
178	Myotonia Congenita	10.5%
179	Bladder Exstrophy	10.2%
180	Epispadias	10.2%
181	Multicystic Dysplastic Kidney	10.2%
182	Sickle Cell Trait	10.1%
183	Canavan Disease	9.9%
184	Alexander Disease	9.9%
185	Meningocele	9.9%
186	Encephalocele	9.9%
187	Ectopia Cordis	9.9%
188	Single umbilical artery	9.9%
189	Welander Distal Myopathy	9.7%
190	Abdominal Cramps	9.5%
191	Amniotic Band Syndrome	9.5%
192	Asphyxia Neonatorum	9.5%
193	Infant, Premature, Diseases	9.5%
194	Infantile Colic	9.5%
195	Hyperandrogenism	9.5%
196	Familial Mediterranean Fever	9.5%
197	Familial Periodic Paralysis	9.3%
198	Glycogen storage disease type II	9.3%
199	Myopathy	9.1%
200	Dystonia Musculorum Deformans	9%
201	Galactosemias	8.9%
202	Urea Cycle Disorders, Inborn	8.9%
203	Tyrosinemias	8.9%
204	Aortic coarctation	8.9%
205	Cor Triatriatum	8.9%
206	Coronary Vessel Anomalies	8.9%
207	Dental Enamel Hypoplasia	8.9%
208	Patent ductus arteriosus	8.9%
209	Ebstein Anomaly	8.9%
210	Heart Septal Defects	8.9%
211	Hypodontia	8.9%
212	Macrostomia	8.9%
213	Microstomia	8.9%
214	Tetralogy of Fallot	8.9%
215	Transposition of Great Vessels	8.9%
216	Hypoplastic Left Heart Syndrome	8.9%
217	May-Thurner Syndrome	8.9%
218	Wolff-Parkinson-White Syndrome	8.8%
219	Optic Atrophy, Hereditary, Leber	8.8%
220	Hyperostosis	8.7%
221	Osteitis	8.7%
222	Osteitis Deformans	8.7%
223	Osteochondrosis	8.7%
224	Spinal Diseases	8.7%
225	Dermal Sinus	8.7%
226	Spina Bifida Cystica	8.7%
227	Spina Bifida Occulta	8.7%
228	Lissencephaly	8.7%
229	Polymicrogyria	8.7%
230	Pachygyria	8.7%
231	Schizencephaly	8.7%
232	Periventricular Nodular Heterotopia	8.7%
233	Acute Chest Syndrome	8.6%
234	Spinal Neoplasms	8.6%
235	Spondylitis	8.6%
236	Anemia, Neonatal	8.5%
237	Persistent Fetal Circulation Syndrome	8.5%
238	Umbilical hernia	8.4%
239	Amino Acid Metabolism, Inborn Errors	8.4%
240	Carbohydrate Metabolism, Inborn Errors	8.4%
241	Metal Metabolism, Inborn Errors	8.4%
242	Progeria	8.4%
243	Lysosomal Storage Diseases	8.4%
244	Cytochrome-c Oxidase Deficiency	8.4%
245	Peroxisomal Disorders	8.4%
246	Arthritis, Gouty	8.4%
247	Lafora Disease	8.4%
248	Unverricht-Lundborg Syndrome	8.4%
249	Fibromyalgia	8.4%
250	Congenital nystagmus	8.3%
251	Pseudohypoparathyroidism	8.2%
252	Contracture	8.2%
253	Fasciitis, Plantar	8.2%
254	Long QT Syndrome	8.1%
255	Tricuspid Atresia	8.1%
256	Arrhythmogenic Right Ventricular Dysplasia	8.1%
257	Toxoplasmosis, Congenital	8.1%
258	Gonadal Dysgenesis	8.1%
259	Adrenogenital Syndrome	8.1%
260	Ovotesticular Disorders of Sex Development	8.1%
261	Fasciitis	8%
262	Foot Deformities	8%
263	Arthropathy	8%
264	Bone Diseases, Endocrine	7.9%
265	Duane Retraction Syndrome	7.9%
266	Hyperphosphaturia	7.9%
267	Bone Diseases, Infectious	7.8%
268	Bone neoplasms	7.8%
269	Osteopenia	7.8%
270	Bone Resorption	7.7%
271	Aseptic Necrosis of Bone	7.7%
272	Gaucher Disease	7.7%
273	Neonatal Abstinence Syndrome	7.7%
274	Cutis Laxa	7.6%
275	Fetal Growth Retardation	7.6%
276	Retinitis Pigmentosa	7.6%
277	Fetal Hypoxia	7.6%
278	Fetal Alcohol Spectrum Disorders	7.6%
279	Pigmentary retinopathy	7.6%
280	Porokeratosis	7.6%
281	Keratoderma, Palmoplantar	7.6%
282	Homocystinuria	7.6%
283	Mucopolysaccharidosis III	7.6%
284	Chronic granulomatous disease	7.6%
285	Syphilis, Congenital	7.6%
286	Leigh Disease	7.5%
287	Brain Diseases, Metabolic, Inborn	7.5%
288	Huntington Disease	7.4%
289	Polymyalgia Rheumatica	7.4%
290	Metatarsalgia	7.3%
291	Jaw Diseases	7.3%
292	Aortopulmonary Septal Defect	7.2%
293	Double Outlet Right Ventricle	7.2%
294	Endocardial Cushion Defects	7.2%
295	Myocardial bridging	7.2%
296	Aorticopulmonary Septal Defect	7.2%
297	Cartilage Diseases	7.2%
298	Foot Diseases	7.2%
299	Rheumatism	7.2%
300	Chondromalacia	7.2%
301	Osteoarthritis, Spine	7.1%
302	Tay-Sachs Disease	7%
303	Chondrodysplasia Punctata	7%
304	Enchondromatosis	7%
305	Osteosclerosis	7%
306	Kashin-Beck Disease	7%
307	Confusion	7%
308	Lethargy	7%
309	Memory Disorders	7%
310	Perceptual Disorders	7%
311	Psychomotor Disorders	7%
312	Anhedonia	7%
313	Disorientation	7%
314	Memory Loss	7%
315	Hemisensory Neglect	7%
316	Porphyrias, Hepatic	6.9%
317	Congenital Hyperinsulinism	6.9%
318	Chorioamnionitis	6.9%
319	Peutz-Jeghers Syndrome	6.9%
320	Thrombasthenia	6.9%
321	Antithrombin III Deficiency	6.9%
322	Protein C Deficiency	6.9%
323	Afibrinogenemia	6.9%
324	Factor VII Deficiency	6.9%
325	Factor X Deficiency	6.9%
326	Factor XII Deficiency	6.9%
327	Hemophilia A	6.9%
328	Activated Protein C Resistance	6.9%
329	Factor II deficiency	6.9%
330	Factor VIII Deficiency	6.9%
331	Factor V deficiency	6.9%
332	Factor XI Deficiency	6.9%
333	Hypoprothrombinemias	6.9%
334	Fanconi Anemia	6.8%
335	Niemann-Pick Disease, Type C	6.8%
336	Hypokalemic periodic paralysis	6.8%
337	Anemia, Diamond-Blackfan	6.8%
338	Hydrops Fetalis	6.8%
339	Carbamoyl-Phosphate Synthase I Deficiency Disease	6.8%
340	Denys-Drash Syndrome	6.6%
341	Muscle Cramp	6.6%
342	Romano-Ward Syndrome	6.5%
343	Multiple Endocrine Neoplasia	6.4%
344	Temporomandibular Joint Disorders	6.4%
345	Consciousness Disorders	6.4%
346	Depressed Level of Consciousness	6.4%
347	Truncus Arteriosus, Persistent	6.3%
348	Dermatitis, Atopic	6.3%
349	Catatonia	6.3%
350	Ischemic contracture	6.3%
351	Akathisia	6.3%
352	Restlessness	6.3%
353	Psychomotor Agitation	6.3%
354	Alkaptonuria	6.2%
355	Glycogen Storage Disease	6.2%
356	Hypophosphatasia	6.2%
357	Propionic acidemia	6.2%
358	Dihydropyrimidine Dehydrogenase Deficiency	6.2%
359	Cystinosis	6.2%
360	Friedreich Ataxia	6.1%
361	Muscle Weakness	6.1%
362	Asterixis	6%
363	Ballismus	6%
364	Rheumatic Fever	6%
365	Familial Hypophosphatemic Rickets	5.9%
366	Discitis	5.9%
367	Chronic Fatigue Syndrome	5.9%
368	Behcet Syndrome	5.8%
369	Temporomandibular Joint Dysfunction Syndrome	5.8%
370	Ophthalmia Neonatorum	5.8%
371	Eosinophilic Granuloma	5.8%
372	Alexia	5.7%
373	Dyslexia	5.7%
374	Leukomalacia, Periventricular	5.7%
375	Muscle Rigidity	5.6%
376	Muscle Spasticity	5.6%
377	Cogwheel Rigidity	5.6%
378	Nuchal Rigidity	5.6%
379	Hypolipoproteinemias	5.6%
380	Papillon-Lefevre Disease	5.6%
381	Ankylosing spondylitis	5.6%
382	Hyperlipidemia, Familial Combined	5.5%
383	Hyperlipoproteinemia Type III	5.5%
384	Decerebrate State	5.5%
385	Hemiparesis	5.5%
386	Meningism	5.5%
387	Paralysis, Obstetric	5.5%
388	Paresis	5.5%
389	Retinopathy of Prematurity	5.5%
390	Seizures	5.5%
391	Sensation Disorders	5.5%
392	Complex partial seizures	5.5%
393	Monoparesis	5.5%
394	Neurogenic Inflammation	5.5%
395	Gait Disorders, Neurologic	5.5%
396	Neuromuscular Manifestations	5.5%
397	Arteriovenous fistula	5.5%
398	Bronchopulmonary Dysplasia	5.5%
399	Rheumatoid Arthritis	5.5%
400	Juvenile arthritis	5.5%
401	MELAS Syndrome	5.4%
402	Ainhum	5.3%
403	Spinal Stenosis	5.3%
404	Spondylosis	5.3%
405	Intervertebral Disc Degeneration	5.3%
406	Tuberculosis, Spinal	5.3%
407	Melorheostosis	5.3%
408	Osteopetrosis	5.3%
409	Alice in Wonderland Syndrome	5.3%
410	Gait Apraxia	5.3%
411	Myositis	5.2%
412	Isaacs syndrome	5.2%
413	Myotonic Disorders	5.2%
414	Hip Contracture	5.1%
415	Periarthritis	5.1%
416	Pupil Disorders	5.1%
417	Language Disorders	5.1%
418	Glycogen Storage Disease Type I	5.1%
419	Glycogen Storage Disease Type V	5.1%
420	Lactose Intolerance	5.1%
421	Variegate Porphyria	5.1%
422	Acute intermittent porphyria	5.1%
423	Porphyria Cutanea Tarda	5.1%
424	Hyperhomocysteinemia	5%
425	Arthritis, Psoriatic	5%
426	Renal Aminoacidurias	5%
427	Fanconi Syndrome	5%
428	Pseudohypoaldosteronism	5%
429	Liddle Syndrome	5%
430	Nephroblastoma	5%
431	Hyperlipoproteinemia Type IV	5%
432	Hyperlipoproteinemia Type V	5%
433	Respiratory Distress Syndrome, Newborn	5%
434	Vertigo	5%
435	Osteomyelitis	4.8%
436	Osteoporosis	4.8%
437	Periostitis	4.8%
438	Bone Demineralization, Pathologic	4.8%
439	Post-Traumatic Osteoporosis	4.8%
440	Alveolar Bone Loss	4.7%
441	Femur Head Necrosis	4.7%
442	Osteolysis	4.7%
443	Medial Tibial Stress Syndrome	4.7%
444	Adenomatous Polyposis Coli	4.7%
445	Acromegaly	4.7%
446	Multiple Endocrine Neoplasia Type 1	4.7%
447	Mitochondrial Myopathies	4.7%
448	Eosinophilia-Myalgia Syndrome	4.6%
449	Renal tubular acidosis	4.6%
450	Voice Disorders	4.6%
451	Voice Disturbance	4.6%
452	Agnosia	4.6%
453	Apraxias	4.6%
454	Hallucinations	4.6%
455	Visual Agnosia	4.6%
456	Anosognosia	4.6%
457	Wernicke-Korsakoff Syndrome	4.6%
458	Arthritis	4.6%
459	Bursitis	4.6%
460	Joint Instability	4.6%
461	Myofascial Pain Syndromes	4.6%
462	Rhabdomyolysis	4.6%
463	Synovitis	4.6%
464	Joint laxity	4.6%
465	Polyarthritis	4.6%
466	Frozen shoulder	4.6%
467	Patellofemoral Pain Syndrome	4.6%
468	Hypoalphalipoproteinemias	4.6%
469	Ophthalmoplegic Migraine	4.5%
470	Nesidioblastosis	4.5%
471	Gait Ataxia	4.5%
472	Arthritis, Reactive	4.4%
473	Osteoarthritis, Knee	4.4%
474	Spondylarthropathies	4.4%
475	Kernicterus	4.3%
476	Joint Tuberculosis	4.3%
477	Tuberculosis, Osteoarticular	4.3%
478	Bone Tuberculosis	4.3%
479	Bone Diseases	4.2%
480	Deformity	4.2%
481	Amnesia	4.2%
482	Delirium	4.2%
483	Dissociative Amnesia	4.2%
484	Global Amnesia	4.2%
485	Cystinuria	4.1%
486	Reflex, Abnormal	4.1%
487	Hyporeflexia	4.1%
488	Hyperreflexia	4.1%
489	Dyskinesia, Drug-Induced	4.1%
490	Compartment syndromes	4.1%
491	Maxillary Diseases	4.1%
492	Tendinitis	4.1%
493	Tendinopathy	4.1%
494	Persistent Vegetative State	4.1%
495	Hemarthrosis	4.1%
496	Tietze's Syndrome	4.1%
497	Auditory Perceptual Disorders	4%
498	Stiff-Person Syndrome	4%
499	Glycosuria, Renal	3.9%
500	Rheumatoid Nodule	3.9%
501	Multiple System Atrophy	3.9%
502	Restless Legs Syndrome	3.9%
503	Rickets	3.9%
504	Brain Death	3.9%
505	Coma, Post-Head Injury	3.9%
506	Myalgia	3.8%
507	Phantom pain	3.8%
508	Phantom Limb Pain	3.8%
509	Agraphia	3.8%
510	Anomia	3.8%
511	Cluttering	3.8%
512	Language Development Disorders	3.8%
513	Speech Disorders	3.8%
514	Syncope	3.8%
515	Stupor	3.8%
516	Dysgraphia	3.8%
517	Presyncope	3.8%
518	Dyslalia	3.8%
519	Cranial nerve diseases	3.8%
520	Demyelinating Diseases	3.8%
521	Demyelination	3.8%
522	Neuromuscular Diseases	3.8%
523	Chronobiology Disorders	3.8%
524	Progressive supranuclear palsy	3.7%
525	Motor Neuron Disease	3.7%
526	Lordosis	3.7%
527	Spondylolysis	3.7%
528	kyphosis	3.7%
529	Amnesia, Transient Global	3.7%
530	Polyradiculoneuropathy	3.6%
531	Polyradiculoneuritis	3.6%
532	Hyaline Membrane Disease	3.6%
533	Ophthalmoplegia	3.6%
534	External Ophthalmoplegia	3.6%
535	Chorea	3.6%
536	Subacute Combined Degeneration	3.6%
537	Felty Syndrome	3.6%
538	Opsoclonus-Myoclonus Syndrome	3.5%
539	Palatal Neoplasms	3.5%
540	Trauma, Nervous System	3.4%
541	Dyscalculia	3.4%
542	Gerstmann Syndrome	3.4%
543	Prosopagnosia	3.4%
544	Apraxia, Ideomotor	3.4%
545	Charles Bonnet Syndrome	3.4%
546	Alien Hand Syndrome	3.4%
547	Ocular Motility Disorders	3.4%
548	Cyclophoria	3.4%
549	Nervous System Neoplasms	3.4%
550	Neurotoxicity Syndromes	3.4%
551	Giant Cell Epulis	3.3%
552	Vocal Cord Paralysis	3.3%
553	Musculoskeletal Pain	3.3%
554	Horner Syndrome	3.3%
555	Amyotrophic Lateral Sclerosis	3.3%
556	Arthralgia	3.3%
557	Polyarthralgia	3.3%
558	Anosmia	3.3%
559	Ataxia	3.3%
560	Athetosis	3.3%
561	Catalepsy	3.3%
562	Dystonia	3.3%
563	Hemiplegia	3.3%
564	Locked-In Syndrome	3.3%
565	Muscle Hypertonia	3.3%
566	Muscle hypotonia	3.3%
567	Myoclonus	3.3%
568	Myotonia	3.3%
569	Paraplegia	3.3%
570	Pseudobulbar Palsy	3.3%
571	Quadriplegia	3.3%
572	Spasm	3.3%
573	Spastic Paraplegia	3.3%
574	Status Epilepticus	3.3%
575	Taste Disorders	3.3%
576	Tremor	3.3%
577	Monoplegia	3.3%
578	Polymyositis	3.3%
579	Hypokinesia	3.3%
580	Paraparesis	3.3%
581	Bradykinesia	3.3%
582	Waxy flexibility	3.3%
583	Action Tremor	3.3%
584	Resting Tremor	3.3%
585	Dysosmia	3.3%
586	Quadriparesis	3.3%
587	Olfaction Disorders	3.3%
588	Myokymia	3.3%
589	Somatosensory Disorders	3.3%
590	Hyperkinesia	3.3%
591	Intention tremor	3.3%
592	Rheumatoid Vasculitis	3.3%
593	Cerebrospinal Fluid Otorrhea	3.3%
594	Cerebrospinal Fluid Rhinorrhea	3.3%
595	Osteoporosis, Postmenopausal	3.3%
596	Aphasia	3.2%
597	Articulation Disorders	3.2%
598	Echolalia	3.2%
599	Stuttering	3.2%
600	Dysphasia	3.2%
601	Retrograde amnesia	3.1%
602	Amnesia, Anterograde	3.1%
603	Sleep Wake Disorders	3.1%
604	Sicca Syndrome	3%
605	Sjogren's Syndrome	3%
606	Alcohol Withdrawal Seizures	3%
607	Vision Disorders	3%
608	Metamorphopsia	3%
609	Visual Impairment	3%
610	Mitochondrial Encephalomyopathies	3%
611	Meningoencephalitis	3%
612	Anisocoria	3%
613	Facial paralysis	3%
614	Tonic Pupil	3%
615	Facial Paresis	3%
616	Dysacusis	3%
617	Orbital Myositis	3%
618	Spinal Muscular Atrophy	3%
619	Progressive Muscular Atrophy	3%
620	Muscular Atrophy	3%
621	Respiratory Paralysis	3%
622	Pyomyositis	3%
623	Encephalomyelitis	3%
624	Prion Diseases	3%
625	Autonomic Dysreflexia	3%
626	Complex Regional Pain Syndromes	3%
627	Tetany	3%
628	Mastoiditis	2.9%
629	Petrositis	2.9%
630	Bunion	2.9%
631	Fibrodysplasia Ossificans Progressiva	2.9%
632	Myoglobinuria	2.9%
633	Myositis Ossificans	2.9%
634	Tenosynovitis	2.9%
635	Sacroiliitis	2.9%
636	Lewy Body Disease	2.9%
637	Guillain-Barre Syndrome	2.9%
638	Mutism	2.9%
639	Selective Mutism	2.9%
640	Spondylolisthesis	2.9%
641	Dysarthria	2.8%
642	Myelitis, Transverse	2.8%
643	Lambert-Eaton Myasthenic Syndrome	2.8%
644	Parkinson Disease	2.8%
645	Leukoencephalitis, Acute Hemorrhagic	2.8%
646	Spinal Cord Injuries	2.7%
647	Amblyopia	2.7%
648	Aphonia	2.7%
649	Pneumocephalus	2.7%
650	Poliomyelitis	2.7%
651	Dysphonia	2.7%
652	Peripheral Nerve Injuries	2.7%
653	Miller Fisher Syndrome	2.7%
654	Osteomalacia	2.7%
655	Myasthenia Gravis	2.7%
656	Neuromyelitis Optica	2.6%
657	Cerebellar Ataxia	2.6%
658	Torticollis	2.6%
659	Arthritis, Infectious	2.6%
660	Marchiafava-Bignami Disease	2.6%
661	Alexia, Pure	2.6%
662	Anterior Compartment Syndrome	2.6%
663	Enthesopathy	2.6%
664	Arthritis, Experimental	2.6%
665	Abdominal Compartment Syndrome	2.6%
666	Striatonigral Degeneration	2.5%
667	Bone Diseases, Developmental	2.5%
668	Sleep Disorders, Circadian Rhythm	2.5%
669	Tardive Dyskinesia	2.4%
670	Botulism	2.4%
671	Epidural Abscess	2.4%
672	Olfactory Nerve Injuries	2.4%
673	Kearns-Sayre syndrome	2.4%
674	Hip Dislocation	2.3%
675	Shoulder Dislocation	2.3%
676	Hip Dysplasia	2.3%
677	Leukoencephalopathy, Progressive Multifocal	2.3%
678	Shy-Drager Syndrome	2.3%
679	MPTP Poisoning	2.3%
680	Neuroleptic Malignant Syndrome	2.3%
681	Myelinolysis, Central Pontine	2.3%
682	Dupuytren Contracture	2.3%
683	Hoarseness	2.3%
684	Causalgia	2.3%
685	Encephalomyelitis, Acute Disseminated	2.2%
686	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.2%
687	Akathisia, Drug-Induced	2.2%
688	Myelitis	2.2%
689	Progressive bulbar palsy	2.2%
690	Bulbar palsy	2.2%
691	Facial Nerve Injuries	2.2%
692	Dysgeusia	2.2%
693	Formication	2.2%
694	Hyperalgesia	2.2%
695	Hyperesthesia	2.2%
696	Hypesthesia	2.2%
697	Numbness	2.2%
698	Paresthesia	2.2%
699	Paraparesis, Spastic	2.2%
700	Trismus	2.2%
701	Epilepsia Partialis Continua	2.2%
702	Hypogeusia	2.2%
703	Brown-Sequard Syndrome	2.2%
704	Lockjaw	2.2%
705	Allodynia	2.2%
706	Ageusia	2.2%
707	Nose Neoplasms	2.2%
708	Renal Osteodystrophy	2.1%
709	Renal rickets	2.1%
710	Lupus Vasculitis, Central Nervous System	2.1%
711	Brain Diseases	2.1%
712	Dysautonomia	2.1%
713	Meningitis	2.1%
714	Movement Disorders	2.1%
715	Pachymeningitis	2.1%
716	Spinal Cord Diseases	2.1%
717	Vagus Nerve Disorder	2.1%
718	Glossopharyngeal Neuralgia	2.1%
719	Abducens Nerve Diseases	2.1%
720	Heavy Metal Poisoning, Nervous System	2.1%
721	Neuromuscular Junction Diseases	2.1%
722	Tauopathies	2.1%
723	Trochlear Nerve Diseases	2.1%
724	Peripheral Nervous System Diseases	2.1%
725	Shoulder Pain	2.1%
726	Myasthenia Gravis, Autoimmune, Experimental	2%
727	Brain Injuries	2%
728	Diplopia	2%
729	Scotoma	2%
730	Photophobia	2%
731	Hemifacial Spasm	2%
732	Amaurosis	2%
733	Blindness	2%
734	Brain Neoplasms	2%
735	Multiple Sclerosis	2%
736	Spinal Cord Neoplasms	2%
737	Hemianopsia	2%
738	Hyperacusis	2%
739	Tinnitus	2%
740	Phonophobia	2%
741	Hearing Loss	2%
742	Dermatomyositis	2%
743	Sarcopenia	2%
744	Vasculitis, Central Nervous System	1.9%
745	Jet Lag Syndrome	1.9%
746	Limbic Encephalitis	1.9%
747	Central Nervous System Infection	1.9%
748	Optic Neuropathy	1.9%
749	Facial Nerve Diseases	1.9%
750	Craniocerebral Trauma	1.9%
751	Parasomnia	1.9%
752	Dyssomnias	1.9%
753	Vestibulocochlear Nerve Diseases	1.8%
754	Central Nervous System Neoplasms	1.8%
755	Sweating, Gustatory	1.8%
756	Auriculotemporal Syndrome	1.8%
757	Reflex Sympathetic Dystrophy	1.8%
758	Subdural Effusion	1.8%
759	Parkinsonian Disorders	1.8%
760	Nocturnal Myoclonus Syndrome	1.8%
761	Brain Abscess	1.8%
762	Color blindness	1.8%
763	Epilepsy, Post-Traumatic	1.8%
764	Dementia, Vascular	1.7%
765	Brain Hemorrhage, Traumatic	1.7%
766	Paraneoplastic Encephalomyelitis	1.7%
767	Uveomeningoencephalitic Syndrome	1.7%
768	Scrapie	1.7%
769	Sturge-Weber Syndrome	1.7%
770	Central Cord Syndrome	1.7%
771	Alcohol-Induced Disorders, Nervous System	1.7%
772	Dysostoses	1.6%
773	Presenile dementia	1.6%
774	Senile dementia	1.6%
775	Meningitis, Bacterial	1.6%
776	Meningitis, Fungal	1.6%
777	Acrodynia	1.6%
778	Carotid Artery Injuries	1.5%
779	Paraneoplastic Cerebellar Degeneration	1.5%
780	Neuritis, Autoimmune, Experimental	1.5%
781	Cerebellar Neoplasms	1.5%
782	Amaurosis Fugax	1.5%
783	Blindness, Cortical	1.5%
784	Deafness	1.5%
785	Hearing Loss, Sudden	1.5%
786	Hearing Loss, Bilateral	1.5%
787	Hearing Loss, High-Frequency	1.5%
788	Hearing Loss, Mixed Conductive-Sensorineural	1.5%
789	Hearing Loss, Unilateral	1.5%
790	Complete Hearing Loss	1.5%
791	Deaf Mutism	1.5%
792	Meige Syndrome	1.5%
793	Brachial Plexus Neuritis	1.5%
794	Neuralgic Amyotrophy	1.5%
795	Cerebral Ventriculitis	1.5%
796	Optic Nerve Glioma	1.4%
797	Tuberculosis, Meningeal	1.4%
798	Creutzfeldt-Jakob disease	1.3%
799	Basal Ganglia Cerebrovascular Disease	1.3%
800	Brain Injuries, Diffuse	1.3%
801	Traumatic Brain Injury	1.3%
802	Supratentorial Neoplasms	1.3%
803	Multiple Sclerosis, Chronic Progressive	1.3%
804	Multiple Sclerosis, Relapsing-Remitting	1.3%
805	Toxoplasmosis, Cerebral	1.3%
806	Tarsal Tunnel Syndrome	1.3%
807	Cauda Equina Syndrome	1.3%
808	Posterior Leukoencephalopathy Syndrome	1.3%
809	Posterior reversible encephalopathy syndrome	1.3%
810	Brain Concussion	1.3%
811	Akinetic Mutism	1.2%
812	Anoxic Encephalopathy	1.2%
813	Arachnoiditis	1.2%
814	Basal Ganglia Diseases	1.2%
815	Brain Damage, Chronic	1.2%
816	Cerebellar Diseases	1.2%
817	Encephalitis	1.2%
818	Encephalomalacia	1.2%
819	Epilepsy	1.2%
820	Hydrocephalus	1.2%
821	Congenital Hydrocephalus	1.2%
822	Hypothalamic Diseases	1.2%
823	Aseptic Meningitis	1.2%
824	Neuritis	1.2%
825	Polyneuritis	1.2%
826	Radiculitis	1.2%
827	Syringomyelia	1.2%
828	Thalamic Diseases	1.2%
829	Intracranial Hypertension	1.2%
830	Polyneuropathy	1.2%
831	Mononeuritis	1.2%
832	Aura	1.2%
833	Leukoencephalopathy	1.2%
834	Essential Tremor	1.2%
835	Neuroaxonal Dystrophies	1.2%
836	Familial Tremor	1.2%
837	Headache Disorders	1.2%
838	Mononeuropathies	1.2%
839	Intracranial Hypotension	1.2%
840	Brachial Plexus Neuropathies	1.2%
841	Radiculopathy	1.2%
842	Mononeuropathy Multiplex	1.2%
843	Nerve Root Compression	1.2%
844	Brain Edema	1.2%
845	Brain Hypoxia	1.2%
846	Aqueductal Stenosis	1.2%
847	Pneumorrhachis	1.2%
848	Writer's Cramp	1.2%
849	Vertebral Artery Dissection	1.2%
850	Acoustic Neuroma	1.2%
851	Pituitary Adenoma	1.2%
852	Pituitary Neoplasms	1.2%
853	Carpal Tunnel Syndrome	1.1%
854	Vascular Headaches	1.1%
855	neurofibroma	1.1%
856	Hypoxia-Ischemia, Brain	1.1%
857	Sciatica	1.1%
858	Brain Diseases, Metabolic	1.1%
859	Cerebrovascular Disorders	1.1%
860	Optic Atrophy	1.1%
861	Optic Neuritis	1.1%
862	Papilledema	1.1%
863	Strabismus	1.1%
864	Tolosa-Hunt Syndrome	1.1%
865	Cerebrovascular Insufficiency	1.1%
866	Arsenic Poisoning	1.1%
867	Dementia	1.1%
868	Central Nervous System Fungal Infections	1.1%
869	Conus Medullaris Syndrome	1.1%
870	Spinal Cord Vascular Diseases	1.1%
871	Diabetic Neuropathies	1.1%
872	Facial Injuries	1.1%
873	Facial Neuralgia	1.1%
874	Diabetic Amyotrophy	1.1%
875	Diabetic Autonomic Neuropathy	1.1%
876	Sleep Talking	1.1%
877	Manganese Poisoning	1.1%
878	Sleep Disorders, Intrinsic	1.1%
879	Orthostatic intolerance	1.1%
880	Meningeal Neoplasms	1.1%
881	Neuralgia	1.1%
882	Mercury Poisoning, Nervous System	1.1%
883	Lead Poisoning, Nervous System	1.1%
884	Vestibular Neuronitis	1.1%
885	Neuropathic pain	1.1%
886	Myoclonic Epilepsy	1.1%
887	Epilepsy, Temporal Lobe	1.1%
888	Epilepsy, Rolandic	1.1%
889	Benign Rolandic Epilepsy	1.1%
890	Radicular Cyst	1.1%
891	Basal Ganglia Hemorrhage	1.1%
892	Giant Cell Arteritis	1.1%
893	Temporal Arteritis	1.1%
894	Subarachnoid Hemorrhage, Traumatic	1%
895	Carotid Artery, Internal, Dissection	1%
896	Meningitis, Cryptococcal	1%
897	Meningitis, Listeria	1%
898	Meningitis, Haemophilus	1%
899	Meningitis, Pneumococcal	1%
900	Frontotemporal dementia	1%
901	Hand-Arm Vibration Syndrome	1%
902	Optic Neuropathy, Ischemic	1%
903	Anterior Ischemic Optic Neuropathy	1%
904	Central Nervous System Bacterial Infections	1%
905	Subacute Sclerosing Panencephalitis	1%
906	Facial Hemiatrophy	1%
907	Melkersson-Rosenthal Syndrome	1%
908	Sleep Bruxism	1%
909	Cubital Tunnel Syndrome	1%
910	Diffuse Axonal Injury	1%
911	Brain Stem Neoplasms	1%
912	Bell Palsy	0.9%
913	Juvenile Myoclonic Epilepsy	0.9%
914	Myoclonic Epilepsies, Progressive	0.9%
915	Herpes Zoster Oticus	0.9%
916	Putaminal Hemorrhage	0.9%
917	Sleep Deprivation	0.9%
918	Pituitary Apoplexy	0.9%
919	Brain Contusion	0.9%
920	Brain Infarction	0.9%
921	Infarction, Middle Cerebral Artery	0.9%
922	Infarction, Anterior Cerebral Artery	0.9%
923	Infarction, Posterior Cerebral Artery	0.9%
924	Cerebral Palsy	0.8%
925	Epilepsies, Partial	0.8%
926	Epilepsy, Generalized	0.8%
927	Pseudotumor Cerebri	0.8%
928	Sciatic Neuropathy	0.8%
929	Hypertensive Encephalopathy	0.8%
930	Ulnar Neuropathies	0.8%
931	Lesion of Sciatic Nerve	0.8%
932	Simple Partial Seizures	0.8%
933	Epilepsy, Reflex	0.8%
934	Ulnar Neuritis	0.8%
935	Radial nerve compression	0.8%
936	Radial Tunnel Syndrome	0.8%
937	Peroneal Neuropathies	0.8%
938	Radial Neuropathy	0.8%
939	Median Neuropathy	0.8%
940	Sciatic Nerve Palsy	0.8%
941	Femoral Neuropathy	0.8%
942	Tibial Neuropathy	0.8%
943	Ulnar Nerve Palsy	0.8%
944	Postural Orthostatic Tachycardia Syndrome	0.8%
945	Radial nerve palsy	0.8%
946	Headache Disorders, Primary	0.8%
947	Headache Disorders, Secondary	0.8%
948	Medication overuse headache	0.8%
949	Hematoma, Subdural	0.8%
950	Hematoma, Epidural, Cranial	0.8%
951	Choroid Plexus Papilloma	0.8%
952	West Nile Fever	0.8%
953	Alcohol Withdrawal Delirium	0.8%
954	Pituitary Diseases	0.7%
955	Moyamoya Disease	0.7%
956	Neurofibrosarcoma	0.7%
957	Cerebral Infarction	0.7%
958	Brain Stem Infarctions	0.7%
959	Thoracic Outlet Syndrome	0.7%
960	Carotid Artery Diseases	0.7%
961	Brain Ischemia	0.7%
962	Esotropia	0.7%
963	Exotropia	0.7%
964	Hypotension, Orthostatic	0.7%
965	Sleep Apnea Syndromes	0.7%
966	Cerebrovascular accident	0.7%
967	Kluver-Bucy Syndrome	0.7%
968	Vasospasm, Intracranial	0.7%
969	Spinal Cord Ischemia	0.7%
970	Intracranial Arterial Diseases	0.7%
971	Post-Exercise Hypotension	0.7%
972	Disorders of Excessive Somnolence	0.7%
973	Sleep Initiation and Maintenance Disorders	0.7%
974	Night Terrors	0.7%
975	Somnambulism	0.7%
976	Trigeminal Nerve Disorder	0.7%
977	Transient Insomnia	0.7%
978	Sleep Paralysis	0.7%
979	Chronic Insomnia	0.7%
980	REM Sleep Behavior Disorder	0.7%
981	Hypersomnia	0.7%
982	Meningeal Carcinomatosis	0.7%
983	Lead Poisoning, Nervous System, Childhood	0.7%
984	Lead Poisoning, Nervous System, Adult	0.7%
985	Tuberculosis, Central Nervous System	0.7%
986	Eye Injuries	0.7%
987	Lateral Medullary Syndrome	0.7%
988	Reye Syndrome	0.7%
989	Neuroaspergillosis	0.7%
990	Intracranial Embolism and Thrombosis	0.7%
991	Hepatic Encephalopathy	0.7%
992	Hematoma, Subdural, Intracranial	0.7%
993	Hematoma, Subdural, Chronic	0.7%
994	Hematoma, Subdural, Acute	0.7%
995	Polyradiculopathy	0.6%
996	Post-Traumatic Headache	0.6%
997	Pseudorabies	0.6%
998	Tension Headache	0.6%
999	Epilepsy, Complex Partial	0.6%
1000	Migraine Disorders	0.6%
1001	Abdominal Migraine	0.6%
1002	Status Migrainosus	0.6%
1003	Cervicogenic Headache	0.6%
1004	Meningioma	0.6%
1005	Neurosyphilis	0.6%
1006	Waterhouse-Friderichsen Syndrome	0.6%
1007	Empty Sella Syndrome	0.6%
1008	Hyperpituitarism	0.6%
1009	Hypopituitarism	0.6%
1010	Hypophysitis	0.6%
1011	Wernicke Encephalopathy	0.5%
1012	AIDS Dementia Complex	0.5%
1013	Cerebral Arterial Diseases	0.5%
1014	Vertebrobasilar Insufficiency	0.5%
1015	Anterior Spinal Artery Syndrome	0.5%
1016	Basilar Artery Stenosis	0.5%
1017	Vertebral Artery Stenosis	0.5%
1018	Sleep Apnea, Obstructive	0.5%
1019	Sleep Apnea, Central	0.5%
1020	Intracranial Hemorrhage, Hypertensive	0.5%
1021	Transient Cerebral Ischemia	0.5%
1022	Narcolepsy	0.5%
1023	Trigeminal Neuralgia	0.5%
1024	Kleine-Levin Syndrome	0.5%
1025	Lyme Neuroborreliosis	0.5%
1026	Cluster Headache	0.5%
1027	Migraine with Aura	0.5%
1028	Familial Hemiplegic Migraine	0.5%
1029	Chronic Paroxysmal Hemicrania	0.5%
1030	SUNCT Syndrome	0.5%
1031	Paroxysmal Hemicrania	0.5%
1032	Eye Burns	0.5%
1033	Malaria, Cerebral	0.5%
1034	Carotid Stenosis	0.5%
1035	Intracranial Aneurysm	0.5%
1036	Neurocysticercosis	0.5%
1037	Intracranial Arteriosclerosis	0.5%
1038	Cerebral Atherosclerosis	0.5%
1039	Subarachnoid Hemorrhage	0.5%
1040	Cerebral Arteriosclerosis	0.5%
1041	Cerebral Hemorrhage	0.5%
1042	Cerebral Thrombosis	0.5%
1043	Intracranial Embolism	0.5%
1044	Intracranial Thrombosis	0.5%
1045	Hyperprolactinemia	0.5%
1046	Subclavian Steal Syndrome	0.5%
1047	Pick Disease of the Brain	0.5%
1048	Cataplexy	0.5%
1049	Corneal Scar	0.5%
1050	Carotid Artery Thrombosis	0.4%
1051	Cerebral Amyloid Angiopathy	0.4%
1052	Sinus Thrombosis, Intracranial	0.4%
1053	Corneal Perforation	0.4%
1054	Cavernous Sinus Thrombosis	0.4%
1055	Sagittal Sinus Thrombosis	0.4%
1056	Prolactinoma	0.3%
1057	Growth Hormone-Secreting Pituitary Adenoma	0.3%
1058	Nelson Syndrome	0.3%

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