MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Arachnoiditis

(UMLS:C0003708)

Definition:: Acute or chronic inflammation of the arachnoid membrane of the meninges most often involving the spinal cord or base of the brain. This term generally refers to a persistent inflammatory process characterized by thickening of the ARACHNOID membrane and dural adhesions. Associated conditions include prior surgery, infections, trauma, SUBARACHNOID HEMORRHAGE, and chemical irritation. Clinical features vary with the site of inflammation, but include cranial neuropathies, radiculopathies, and myelopathies. (From Joynt, Clinical Neurology, 1997, Ch48, p25)
UMLS ID:: C0003708
MeSH ID:: D001100

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.614.097

Synonym(s)

Arachnoiditis

ARACHNOIDITIS

Arachnoiditis, NOS

arachnitis

arachnoiditis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methylprednisolone Acetate	FAERS: 37 Canada Vigilance: 1	1257435 1772484 4740461	CTD OFFSIDES Canada Vigilance US FAERS
2	Baclofen	FAERS: 17		US FAERS
3	Methotrexate	FAERS: 16	View details 4125793 8136745 9122123 14561622 15891563	CTD SIDER US FAERS
4	Cytarabine	FAERS: 13 Canada Vigilance: 1	11161370 15891563	CTD OFFSIDES SIDER Canada Vigilance US FAERS
5	Iohexol	FAERS: 11		US FAERS
6	Pregabalin	FAERS: 4		SIDER US FAERS
7	Triamcinolone Acetonide	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
8	rofecoxib	FAERS: 4		US FAERS
9	Chlorhexidine	FAERS: 3		US FAERS
10	Fentanyl	FAERS: 3		US FAERS
11	Gadolinium DTPA	FAERS: 3		US FAERS
12	Methotrexate	FAERS: 3		US FAERS
13	betamethasone acetate phosphate	FAERS: 3		US FAERS
14	Bupivacaine	FAERS: 2		OFFSIDES SIDER US FAERS
15	Dasatinib	FAERS: 2		US FAERS
16	Fentanyl	FAERS: 2		US FAERS
17	Iophendylate	FAERS: 2		US FAERS
18	Methylene Blue	FAERS: 2		US FAERS
19	Morphine	FAERS: 2		US FAERS
20	Arthrotec	FAERS: 1		US FAERS
21	Betamethasone	FAERS: 1		US FAERS
22	Budesonide	FAERS: 1		US FAERS
23	Gabapentin	FAERS: 1		US FAERS
24	Gatifloxacin	FAERS: 1		US FAERS
25	Hydromorphone	FAERS: 1		US FAERS
26	Ibandronic Acid	FAERS: 1		US FAERS
27	Iopamidol	FAERS: 1		US FAERS
28	Levofloxacin	FAERS: 1		US FAERS
29	Medroxyprogesterone Acetate	FAERS: 1		US FAERS
30	Methylprednisolone Hemisuccinate	FAERS: 1		US FAERS
31	Methylprednisolone	FAERS: 1		SIDER US FAERS
32	Morphine sulfate	FAERS: 1		US FAERS
33	Prednisone	FAERS: 1		SIDER US FAERS
34	Tapentadol	FAERS: 1		US FAERS
35	Triamcinolone	FAERS: 1		SIDER US FAERS
36	Warfarin	FAERS: 1		US FAERS
37	[(8S,9S,10R,13S,14S,17R)-17-Hydroxy-17-(2-hydroxyacetyl)-1,10,13-trimethyl-3,11-dioxo-6,7,8,9,12,14,15,16-octahydrocyclopenta[a]phenanthren-2-yl] acetate	FAERS: 1		US FAERS
38	ziconotide	FAERS: 1		US FAERS
39	Alendronate			OFFSIDES
40	Clobazam			OFFSIDES
41	Daunorubicin			OFFSIDES
42	Dexamethasone			SIDER
43	Estrogens, Conjugated (USP)			OFFSIDES
44	Ethylene Glycol		3291836	CTD
45	Gentamicins		785039	CTD
46	Hydrocortisone			SIDER
47	Lidoderm			SIDER
48	Melphalan		8043096	CTD
49	Nitrofurantoin			OFFSIDES
50	Paramethasone		9528075	CTD
51	Pentazocine		6477021	CTD
52	Prednisolone		15891563	CTD SIDER
53	Prilocaine			SIDER
54	Procaine			SIDER
55	Ribavirin			OFFSIDES
56	Ropivacaine			OFFSIDES SIDER
57	Tetracaine			SIDER
58	Tiagabine			OFFSIDES
59	Tobramycin		785039	CTD
60	butamben		2265169	CTD
61	cevimeline			OFFSIDES
62	chloroprocaine			SIDER
63	ferrous gluconate			OFFSIDES
64	iocarmate meglumine		1257435	CTD
65	iotrolan			SIDER
66	tegaserod			OFFSIDES
67	valdecoxib			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Aseptic Meningitis	46.7%
2	Meningoencephalitis	38.2%
3	Encephalomyelitis	34.1%
4	Brain Diseases	31%
5	Movement Disorders	31%
6	Spinal Cord Diseases	31%
7	Meningitis, Bacterial	30.6%
8	Meningitis, Fungal	30.6%
9	Myelitis	26.7%
10	Subdural Effusion	23.1%
11	Parkinsonian Disorders	23.1%
12	Central Nervous System Infection	22%
13	Ocular Motility Disorders	21.8%
14	Cyclophoria	21.8%
15	Epidural Abscess	21.7%
16	Multiple System Atrophy	20.8%
17	Prion Diseases	20.5%
18	Akinetic Mutism	20%
19	Anoxic Encephalopathy	20%
20	Basal Ganglia Diseases	20%
21	Brain Damage, Chronic	20%
22	Cerebellar Diseases	20%
23	Encephalitis	20%
24	Encephalomalacia	20%
25	Epilepsy	20%
26	Hydrocephalus	20%
27	Congenital Hydrocephalus	20%
28	Hypothalamic Diseases	20%
29	Syringomyelia	20%
30	Thalamic Diseases	20%
31	Intracranial Hypertension	20%
32	Aura	20%
33	Leukoencephalopathy	20%
34	Essential Tremor	20%
35	Neuroaxonal Dystrophies	20%
36	Familial Tremor	20%
37	Headache Disorders	20%
38	Intracranial Hypotension	20%
39	Brain Edema	20%
40	Brain Hypoxia	20%
41	Aqueductal Stenosis	20%
42	Pneumorrhachis	20%
43	Writer's Cramp	20%
44	Pneumocephalus	19.9%
45	Meige Syndrome	19.6%
46	Cerebral Ventriculitis	19.6%
47	Tuberculosis, Meningeal	19.3%
48	Parkinson Disease	18.7%
49	Meningitis, Cryptococcal	18.6%
50	Cranial nerve diseases	18.5%
51	Demyelinating Diseases	18.5%
52	Demyelination	18.5%
53	Neuromuscular Diseases	18.5%
54	Chronobiology Disorders	18.5%
55	Meningitis, Listeria	18.4%
56	Meningitis, Haemophilus	18.4%
57	Meningitis, Pneumococcal	18.4%
58	Posterior Leukoencephalopathy Syndrome	17.8%
59	Posterior reversible encephalopathy syndrome	17.8%
60	Lewy Body Disease	17.4%
61	Marchiafava-Bignami Disease	16.9%
62	Spinal Muscular Atrophy	16.7%
63	Progressive Muscular Atrophy	16.7%
64	Stiff-Person Syndrome	16.4%
65	Myoclonic Epilepsy	16.1%
66	Epilepsy, Temporal Lobe	16.1%
67	Epilepsy, Rolandic	16.1%
68	Benign Rolandic Epilepsy	16.1%
69	Brain Abscess	16.1%
70	Spinal Cord Injuries	16.1%
71	Dandy-Walker Syndrome	16%
72	Poliomyelitis	15.9%
73	Striatonigral Degeneration	15.3%
74	Lupus Vasculitis, Central Nervous System	15.3%
75	Asterixis	15.3%
76	Ballismus	15.3%
77	Cerebral Palsy	14.8%
78	Epilepsies, Partial	14.8%
79	Epilepsy, Generalized	14.8%
80	Creutzfeldt-Jakob disease	14.8%
81	Pseudotumor Cerebri	14.8%
82	Hypertensive Encephalopathy	14.8%
83	Simple Partial Seizures	14.8%
84	Epilepsy, Reflex	14.8%
85	Basal Ganglia Cerebrovascular Disease	14.8%
86	Headache Disorders, Primary	14.8%
87	Headache Disorders, Secondary	14.8%
88	Medication overuse headache	14.8%
89	Dystonia Musculorum Deformans	14.5%
90	Juvenile Myoclonic Epilepsy	14.4%
91	Myoclonic Epilepsies, Progressive	14.4%
92	Motor Neuron Disease	14%
93	Brain Diseases, Metabolic	13.6%
94	Cerebrovascular Disorders	13.6%
95	Epilepsy, Post-Traumatic	13.6%
96	Cerebrovascular Insufficiency	13.6%
97	Dementia	13.6%
98	Central Nervous System Fungal Infections	13.6%
99	Conus Medullaris Syndrome	13.6%
100	Spinal Cord Vascular Diseases	13.6%
101	Dementia, Vascular	13.6%
102	Subacute Combined Degeneration	13.5%
103	Vascular Headaches	13.5%
104	MPTP Poisoning	13.4%
105	Hypoxia-Ischemia, Brain	13.4%
106	Brain Injuries	13.3%
107	Amyotrophic Lateral Sclerosis	13.3%
108	Brain Neoplasms	13.2%
109	Spinal Cord Neoplasms	13.2%
110	Chronic Fatigue Syndrome	12.9%
111	Trauma, Nervous System	12.8%
112	Shy-Drager Syndrome	12.8%
113	Progressive supranuclear palsy	12.7%
114	Neuroleptic Malignant Syndrome	12.6%
115	Myelinolysis, Central Pontine	12.6%
116	Leukoencephalopathy, Progressive Multifocal	12.3%
117	Cerebellar Neoplasms	12.2%
118	Nervous System Neoplasms	12.2%
119	Neurologic Manifestations	12.2%
120	Post-Traumatic Headache	12.2%
121	Tension Headache	12.2%
122	Epilepsy, Complex Partial	12.2%
123	Migraine Disorders	12.2%
124	Neurotoxicity Syndromes	12.2%
125	Abdominal Migraine	12.2%
126	Status Migrainosus	12.2%
127	Cervicogenic Headache	12.2%
128	Huntington Disease	12.1%
129	Limbic Encephalitis	12%
130	Leukomalacia, Periventricular	11.8%
131	Brain Death	11.7%
132	Autonomic Dysreflexia	11.4%
133	Complex Regional Pain Syndromes	11.4%
134	Myelitis, Transverse	10.9%
135	Cluster Headache	10.9%
136	Migraine with Aura	10.9%
137	Familial Hemiplegic Migraine	10.9%
138	Chronic Paroxysmal Hemicrania	10.9%
139	SUNCT Syndrome	10.9%
140	Paroxysmal Hemicrania	10.9%
141	Scrapie	10.9%
142	Central Cord Syndrome	10.9%
143	Lafora Disease	10.9%
144	Unverricht-Lundborg Syndrome	10.9%
145	Presenile dementia	10.7%
146	Senile dementia	10.7%
147	Chorea	10.7%
148	Pituitary Diseases	10.6%
149	Friedreich Ataxia	10.6%
150	Toxoplasmosis, Cerebral	10.4%
151	Dysautonomia	10.3%
152	Vagus Nerve Disorder	10.3%
153	Glossopharyngeal Neuralgia	10.3%
154	Abducens Nerve Diseases	10.3%
155	Heavy Metal Poisoning, Nervous System	10.3%
156	Neuromuscular Junction Diseases	10.3%
157	Central Nervous System Bacterial Infections	10.3%
158	Tauopathies	10.3%
159	Trochlear Nerve Diseases	10.3%
160	Peripheral Nervous System Diseases	10.3%
161	Ophthalmoplegic Migraine	10.3%
162	Polyradiculoneuropathy	10.2%
163	Polyradiculoneuritis	10.2%
164	Leukoencephalitis, Acute Hemorrhagic	10.2%
165	Encephalomyelitis, Acute Disseminated	10.2%
166	Akathisia, Drug-Induced	10.1%
167	Amblyopia	10%
168	Basal Ganglia Hemorrhage	9.9%
169	Carotid Artery Diseases	9.9%
170	Brain Ischemia	9.9%
171	Cerebrovascular accident	9.9%
172	Kluver-Bucy Syndrome	9.9%
173	Vasospasm, Intracranial	9.9%
174	Spinal Cord Ischemia	9.9%
175	Intracranial Arterial Diseases	9.9%
176	Pituitary Apoplexy	9.9%
177	Brain Injuries, Diffuse	9.8%
178	Traumatic Brain Injury	9.8%
179	Cerebellar Ataxia	9.7%
180	Supratentorial Neoplasms	9.7%
181	Torticollis	9.7%
182	Tuberculosis, Central Nervous System	9.7%
183	Brain Infarction	9.7%
184	Restless Legs Syndrome	9.7%
185	Opsoclonus-Myoclonus Syndrome	9.6%
186	Sleep Wake Disorders	9.3%
187	Persistent Vegetative State	9.3%
188	Dyskinesia, Drug-Induced	9.1%
189	Putaminal Hemorrhage	9%
190	Subacute Sclerosing Panencephalitis	9%
191	Hepatolenticular Degeneration	8.9%
192	Progressive bulbar palsy	8.9%
193	Bulbar palsy	8.9%
194	Infarction, Middle Cerebral Artery	8.8%
195	Infarction, Anterior Cerebral Artery	8.8%
196	Infarction, Posterior Cerebral Artery	8.8%
197	Carotid Artery Injuries	8.8%
198	Miller Fisher Syndrome	8.8%
199	Brain Hemorrhage, Traumatic	8.8%
200	Pituitary Adenoma	8.7%
201	Pituitary Neoplasms	8.7%
202	Cerebral Infarction	8.6%
203	Brain Stem Infarctions	8.6%
204	Peripheral Nerve Injuries	8.6%
205	Paraneoplastic Cerebellar Degeneration	8.6%
206	Myasthenia Gravis	8.5%
207	Tardive Dyskinesia	8.5%
208	Empty Sella Syndrome	8.4%
209	Hyperpituitarism	8.4%
210	Hypopituitarism	8.4%
211	Hypophysitis	8.4%
212	Vasculitis, Central Nervous System	8.4%
213	Causalgia	8.2%
214	Cerebral Arterial Diseases	8.1%
215	Vertebrobasilar Insufficiency	8.1%
216	Lateral Medullary Syndrome	8.1%
217	Anterior Spinal Artery Syndrome	8.1%
218	Basilar Artery Stenosis	8.1%
219	Vertebral Artery Stenosis	8.1%
220	Intracranial Hemorrhage, Hypertensive	8.1%
221	Transient Cerebral Ischemia	8.1%
222	Diffuse Axonal Injury	8%
223	Brain Stem Neoplasms	8%
224	Canavan Disease	8%
225	Alexander Disease	8%
226	Guillain-Barre Syndrome	7.9%
227	Amnesia, Transient Global	7.9%
228	Waterhouse-Friderichsen Syndrome	7.8%
229	Reflex Sympathetic Dystrophy	7.7%
230	Nocturnal Myoclonus Syndrome	7.7%
231	Moyamoya Disease	7.7%
232	Reye Syndrome	7.4%
233	Neuroaspergillosis	7.4%
234	Intracranial Embolism and Thrombosis	7.4%
235	Hepatic Encephalopathy	7.4%
236	Hyperprolactinemia	7.4%
237	Myopathy	7.3%
238	Optic Neuropathy	7.3%
239	Subclavian Steal Syndrome	7.2%
240	Pick Disease of the Brain	7.2%
241	Olfactory Nerve Injuries	7.2%
242	Choroid Plexus Papilloma	7.2%
243	West Nile Fever	7.2%
244	Sleep Disorders, Circadian Rhythm	7%
245	Facial Nerve Diseases	7%
246	Craniocerebral Trauma	7%
247	Parasomnia	7%
248	Dyssomnias	7%
249	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	6.9%
250	Vestibulocochlear Nerve Diseases	6.8%
251	Decerebrate State	6.8%
252	Hemiparesis	6.8%
253	Hydranencephaly	6.8%
254	Meningism	6.8%
255	Neural Tube Defects	6.8%
256	Paresis	6.8%
257	Seizures	6.8%
258	Sensation Disorders	6.8%
259	Tethered Cord Syndrome	6.8%
260	Central Nervous System Neoplasms	6.8%
261	Complex partial seizures	6.8%
262	Iniencephaly	6.8%
263	Craniorachischisis	6.8%
264	Exencephaly	6.8%
265	Monoparesis	6.8%
266	Septo-Optic Dysplasia	6.8%
267	Cortical Dysplasia	6.8%
268	Neurogenic Inflammation	6.8%
269	Gait Disorders, Neurologic	6.8%
270	Neuromuscular Manifestations	6.8%
271	Malformations of Cortical Development	6.8%
272	Frontotemporal dementia	6.8%
273	Sweating, Gustatory	6.7%
274	Auriculotemporal Syndrome	6.7%
275	Botulism	6.7%
276	Central Nervous System Cysts	6.7%
277	Lambert-Eaton Myasthenic Syndrome	6.7%
278	Neuritis	6.7%
279	Polyneuritis	6.7%
280	Radiculitis	6.7%
281	Polyneuropathy	6.7%
282	Mononeuritis	6.7%
283	Mononeuropathies	6.7%
284	Brachial Plexus Neuropathies	6.7%
285	Radiculopathy	6.7%
286	Mononeuropathy Multiplex	6.7%
287	Nerve Root Compression	6.7%
288	Subarachnoid Hemorrhage, Traumatic	6.6%
289	Carotid Artery, Internal, Dissection	6.6%
290	Multiple Sclerosis	6.6%
291	Mitochondrial Encephalomyopathies	6.6%
292	Brachial Plexus Neuritis	6.5%
293	Neuralgic Amyotrophy	6.5%
294	Brain Contusion	6.5%
295	Ataxia Telangiectasia	6.3%
296	Pseudorabies	6.3%
297	Vertebral Artery Dissection	6.3%
298	Toxoplasmosis, Congenital	6.2%
299	Malaria, Cerebral	6.2%
300	Neuromyelitis Optica	6.2%
301	Carotid Stenosis	6.1%
302	Intracranial Aneurysm	6.1%
303	Neurocysticercosis	6.1%
304	Intracranial Arteriosclerosis	6.1%
305	Cerebral Atherosclerosis	6.1%
306	Subarachnoid Hemorrhage	6.1%
307	Cerebral Arteriosclerosis	6.1%
308	Cerebral Hemorrhage	6.1%
309	Cerebral Thrombosis	6%
310	Intracranial Embolism	6%
311	Intracranial Thrombosis	6%
312	Facial Nerve Injuries	6%
313	Brain Concussion	6%
314	Horner Syndrome	6%
315	Brain Diseases, Metabolic, Inborn	6%
316	Tarsal Tunnel Syndrome	5.9%
317	Cauda Equina Syndrome	5.9%
318	Alice in Wonderland Syndrome	5.9%
319	Neurosyphilis	5.8%
320	Acrodynia	5.7%
321	MELAS Syndrome	5.6%
322	Auditory Perceptual Disorders	5.6%
323	Acromegaly	5.5%
324	Cerebral Amyloid Angiopathy	5.4%
325	Sinus Thrombosis, Intracranial	5.4%
326	Ophthalmoplegia	5.4%
327	External Ophthalmoplegia	5.4%
328	Pupil Disorders	5.4%
329	Neurobehavioral Manifestations	5.4%
330	Adrenoleukodystrophy	5.4%
331	Paraneoplastic Encephalomyelitis	5.2%
332	Charcot-Marie-Tooth Disease	5.1%
333	Myasthenia Gravis, Autoimmune, Experimental	5.1%
334	Coma, Post-Head Injury	5.1%
335	Uveomeningoencephalitic Syndrome	5.1%
336	Cavernous Sinus Thrombosis	5.1%
337	Sagittal Sinus Thrombosis	5.1%
338	Sturge-Weber Syndrome	5%
339	Vertigo	5%
340	Alcohol-Induced Disorders, Nervous System	5%
341	Jet Lag Syndrome	5%
342	Wernicke Encephalopathy	4.9%
343	Sciatic Neuropathy	4.9%
344	Ulnar Neuropathies	4.9%
345	Lesion of Sciatic Nerve	4.9%
346	Ulnar Neuritis	4.9%
347	Radial nerve compression	4.9%
348	Radial Tunnel Syndrome	4.9%
349	Peroneal Neuropathies	4.9%
350	Radial Neuropathy	4.9%
351	Median Neuropathy	4.9%
352	Sciatic Nerve Palsy	4.9%
353	Femoral Neuropathy	4.9%
354	Tibial Neuropathy	4.9%
355	Ulnar Nerve Palsy	4.9%
356	Postural Orthostatic Tachycardia Syndrome	4.9%
357	Radial nerve palsy	4.9%
358	AIDS Dementia Complex	4.9%
359	Multiple Sclerosis, Chronic Progressive	4.9%
360	Multiple Sclerosis, Relapsing-Remitting	4.9%
361	Lyme Neuroborreliosis	4.9%
362	Carotid Artery Thrombosis	4.8%
363	Giant Cell Arteritis	4.7%
364	Temporal Arteritis	4.7%
365	Myotonia Congenita	4.6%
366	Refsum Disease	4.6%
367	Cerebrospinal Fluid Otorrhea	4.6%
368	Cerebrospinal Fluid Rhinorrhea	4.6%
369	Neuritis, Autoimmune, Experimental	4.6%
370	Gait Ataxia	4.6%
371	Myositis	4.5%
372	Optic Atrophy	4.5%
373	Optic Neuritis	4.5%
374	Papilledema	4.5%
375	Strabismus	4.5%
376	Tolosa-Hunt Syndrome	4.5%
377	Isaacs syndrome	4.5%
378	Arsenic Poisoning	4.5%
379	Myotonic Disorders	4.5%
380	Myasthenic Syndromes, Congenital	4.5%
381	Vocal Cord Paralysis	4.5%
382	Carpal Tunnel Syndrome	4.5%
383	Hematoma, Subdural	4.5%
384	Hematoma, Epidural, Cranial	4.5%
385	neurofibroma	4.5%
386	Diabetic Neuropathies	4.4%
387	Facial Injuries	4.4%
388	Facial Neuralgia	4.4%
389	Diabetic Amyotrophy	4.4%
390	Diabetic Autonomic Neuropathy	4.4%
391	Sleep Talking	4.4%
392	Manganese Poisoning	4.4%
393	Sleep Disorders, Intrinsic	4.4%
394	Orthostatic intolerance	4.4%
395	Sciatica	4.4%
396	Tuberous Sclerosis	4.4%
397	Anosmia	4.4%
398	Ataxia	4.4%
399	Athetosis	4.4%
400	Catalepsy	4.4%
401	Dystonia	4.4%
402	Hemiplegia	4.4%
403	Locked-In Syndrome	4.4%
404	Meningeal Neoplasms	4.4%
405	Meningomyelocele	4.4%
406	Muscle Hypertonia	4.4%
407	Muscle hypotonia	4.4%
408	Myoclonus	4.4%
409	Myotonia	4.4%
410	Neuralgia	4.4%
411	Paraplegia	4.4%
412	Pseudobulbar Palsy	4.4%
413	Quadriplegia	4.4%
414	Spasm	4.4%
415	Spastic Paraplegia	4.4%
416	Status Epilepticus	4.4%
417	Taste Disorders	4.4%
418	Tremor	4.4%
419	Spina Bifida	4.4%
420	Monoplegia	4.4%
421	Hypokinesia	4.4%
422	Paraparesis	4.4%
423	Bradykinesia	4.4%
424	Waxy flexibility	4.4%
425	Action Tremor	4.4%
426	Resting Tremor	4.4%
427	Dysosmia	4.4%
428	Quadriparesis	4.4%
429	Mercury Poisoning, Nervous System	4.4%
430	Olfaction Disorders	4.4%
431	Myokymia	4.4%
432	Lead Poisoning, Nervous System	4.4%
433	Vestibular Neuronitis	4.4%
434	Somatosensory Disorders	4.4%
435	Neuropathic pain	4.4%
436	Hyperkinesia	4.4%
437	Intention tremor	4.4%
438	Kernicterus	4.3%
439	Voice Disorders	4.2%
440	Voice Disturbance	4.2%
441	Nelson Syndrome	4.1%
442	Polyradiculopathy	4.1%
443	Smith-Magenis syndrome	4.1%
444	Hematoma, Subdural, Intracranial	4%
445	Hematoma, Subdural, Chronic	4%
446	Hematoma, Subdural, Acute	4%
447	Cubital Tunnel Syndrome	4%
448	Dural Arteriovenous Fistula	4%
449	Myotonic Dystrophy	3.9%
450	Akathisia	3.8%
451	Restlessness	3.8%
452	Psychomotor Agitation	3.8%
453	Alcohol Withdrawal Seizures	3.7%
454	Prolactinoma	3.7%
455	Growth Hormone-Secreting Pituitary Adenoma	3.7%
456	Hand-Arm Vibration Syndrome	3.6%
457	Gait Apraxia	3.5%
458	Vision Disorders	3.5%
459	Metamorphopsia	3.5%
460	Visual Impairment	3.5%
461	Galactosemias	3.5%
462	Urea Cycle Disorders, Inborn	3.5%
463	Tyrosinemias	3.5%
464	Fibromyalgia	3.4%
465	Optic Neuropathy, Ischemic	3.4%
466	Anterior Ischemic Optic Neuropathy	3.4%
467	Medial Tibial Stress Syndrome	3.4%
468	Fabry Disease	3.4%
469	Facial Hemiatrophy	3.4%
470	Melkersson-Rosenthal Syndrome	3.4%
471	Mitochondrial Myopathies	3.4%
472	Thoracic Outlet Syndrome	3.4%
473	Anisocoria	3.4%
474	Confusion	3.4%
475	Facial paralysis	3.4%
476	Lethargy	3.4%
477	Memory Disorders	3.4%
478	Muscle Cramp	3.4%
479	Perceptual Disorders	3.4%
480	Psychomotor Disorders	3.4%
481	Tonic Pupil	3.4%
482	Eosinophilia-Myalgia Syndrome	3.4%
483	Anhedonia	3.4%
484	Disorientation	3.4%
485	Facial Paresis	3.4%
486	Memory Loss	3.4%
487	Hemisensory Neglect	3.4%
488	Dysacusis	3.4%
489	Optic Nerve Glioma	3.4%
490	Sleep Bruxism	3.3%
491	Reflex, Abnormal	3.3%
492	Hyporeflexia	3.3%
493	Hyperreflexia	3.3%
494	Anencephaly	3.3%
495	Meningocele	3.3%
496	Muscular Atrophy	3.3%
497	Respiratory Paralysis	3.3%
498	Encephalocele	3.3%
499	Esotropia	3.3%
500	Exotropia	3.3%
501	Hypotension, Orthostatic	3.3%
502	Sleep Apnea Syndromes	3.3%
503	Polymyositis	3.3%
504	Post-Exercise Hypotension	3.3%
505	Tetany	3.3%
506	Disorders of Excessive Somnolence	3.3%
507	Sleep Initiation and Maintenance Disorders	3.3%
508	Night Terrors	3.3%
509	Somnambulism	3.3%
510	Trigeminal Nerve Disorder	3.3%
511	Transient Insomnia	3.3%
512	Sleep Paralysis	3.3%
513	Chronic Insomnia	3.3%
514	REM Sleep Behavior Disorder	3.3%
515	Hypersomnia	3.3%
516	Dermal Sinus	3.2%
517	Dysgeusia	3.2%
518	Formication	3.2%
519	Hyperalgesia	3.2%
520	Hyperesthesia	3.2%
521	Hypesthesia	3.2%
522	Language Disorders	3.2%
523	Numbness	3.2%
524	Paresthesia	3.2%
525	Paraparesis, Spastic	3.2%
526	Spina Bifida Cystica	3.2%
527	Trismus	3.2%
528	Spina Bifida Occulta	3.2%
529	Epilepsia Partialis Continua	3.2%
530	Hypogeusia	3.2%
531	Meningeal Carcinomatosis	3.2%
532	Brown-Sequard Syndrome	3.2%
533	Lissencephaly	3.2%
534	Polymicrogyria	3.2%
535	Pachygyria	3.2%
536	Schizencephaly	3.2%
537	Lockjaw	3.2%
538	Allodynia	3.2%
539	Lead Poisoning, Nervous System, Childhood	3.2%
540	Lead Poisoning, Nervous System, Adult	3.2%
541	Periventricular Nodular Heterotopia	3.2%
542	Ageusia	3.2%
543	Alstrom Syndrome	3.1%
544	Homocystinuria	3.1%
545	Leigh Disease	3%
546	Classical Lissencephalies and Subcortical Band Heterotopias	2.9%
547	Menkes Kinky Hair Syndrome	2.9%
548	Amyloid Neuropathies, Familial	2.8%
549	Duane Retraction Syndrome	2.7%
550	Consciousness Disorders	2.7%
551	Mental Retardation	2.7%
552	Muscle Weakness	2.7%
553	Depressed Level of Consciousness	2.7%
554	Mental deficiency	2.7%
555	Intellectual Disability	2.7%
556	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.7%
557	Mobius Syndrome	2.7%
558	Bell Palsy	2.7%
559	Sleep Apnea, Obstructive	2.7%
560	Sleep Apnea, Central	2.7%
561	Narcolepsy	2.7%
562	Trigeminal Neuralgia	2.7%
563	Kleine-Levin Syndrome	2.7%
564	Catatonia	2.7%
565	Agraphia	2.7%
566	Alexia	2.7%
567	Anomia	2.7%
568	Cluttering	2.7%
569	Language Development Disorders	2.7%
570	Speech Disorders	2.7%
571	Syncope	2.7%
572	Stupor	2.7%
573	Dysgraphia	2.7%
574	Dyslexia	2.7%
575	Presyncope	2.7%
576	Dyslalia	2.7%
577	Herpes Zoster Oticus	2.7%
578	Familial Periodic Paralysis	2.7%
579	Aphonia	2.6%
580	Sleep Deprivation	2.6%
581	Dysphonia	2.6%
582	Acoustic Neuroma	2.6%
583	Eye Injuries	2.6%
584	Neurofibrosarcoma	2.5%
585	Muscular Dystrophy	2.5%
586	Congenital nystagmus	2.5%
587	Orbital Myositis	2.5%
588	Diplopia	2.5%
589	Muscle Rigidity	2.5%
590	Muscle Spasticity	2.5%
591	Scotoma	2.5%
592	Photophobia	2.5%
593	Cogwheel Rigidity	2.5%
594	Hemifacial Spasm	2.5%
595	Amaurosis	2.5%
596	Blindness	2.5%
597	Nuchal Rigidity	2.5%
598	Pyomyositis	2.5%
599	Agnosia	2.4%
600	Apraxias	2.4%
601	Hallucinations	2.4%
602	Hemianopsia	2.4%
603	Hyperacusis	2.4%
604	Tinnitus	2.4%
605	Visual Agnosia	2.4%
606	Anosognosia	2.4%
607	Wernicke-Korsakoff Syndrome	2.4%
608	Phonophobia	2.4%
609	Hearing Loss	2.4%
610	Sarcopenia	2.4%
611	Cataplexy	2.4%
612	Aphasia	2.4%
613	Articulation Disorders	2.4%
614	Echolalia	2.4%
615	Stuttering	2.4%
616	Dysphasia	2.4%
617	Glycogen storage disease type II	2.4%
618	Dysarthria	2.3%
619	Optic Atrophy, Hereditary, Leber	2.2%
620	Zellweger Syndrome	2.2%
621	Myalgia	2.2%
622	Kearns-Sayre syndrome	2.2%
623	Neuronal Ceroid-Lipofuscinoses	2.2%
624	Eye Burns	2.1%
625	Welander Distal Myopathy	2%
626	Amaurosis Fugax	2%
627	Blindness, Cortical	2%
628	Dyscalculia	2%
629	Rett Syndrome	2%
630	Gaucher Disease	2%
631	Deafness	2%
632	Hearing Loss, Sudden	2%
633	Gerstmann Syndrome	2%
634	Hearing Loss, Bilateral	2%
635	Hearing Loss, High-Frequency	2%
636	Hearing Loss, Mixed Conductive-Sensorineural	2%
637	Prosopagnosia	2%
638	Apraxia, Ideomotor	2%
639	Charles Bonnet Syndrome	2%
640	Hearing Loss, Unilateral	2%
641	Complete Hearing Loss	2%
642	Alien Hand Syndrome	2%
643	Deaf Mutism	2%
644	Amnesia	2%
645	Delirium	2%
646	Dissociative Amnesia	2%
647	Color blindness	2%
648	Global Amnesia	2%
649	Cri-du-Chat Syndrome	2%
650	Down Syndrome	2%
651	Trisomy 21	2%
652	POEMS Syndrome	2%
653	Meningioma	2%
654	Williams Syndrome	2%
655	Microcephaly	2%
656	Macrocephaly	2%
657	Hypokalemic periodic paralysis	1.9%
658	Porencephaly	1.9%
659	Aicardi's syndrome	1.9%
660	Tay-Sachs Disease	1.9%
661	Hoarseness	1.9%
662	Cockayne Syndrome	1.9%
663	Alcohol Withdrawal Delirium	1.9%
664	Mutism	1.8%
665	Selective Mutism	1.8%
666	Niemann-Pick Disease, Type C	1.8%
667	Alexia, Pure	1.7%
668	Dermatomyositis	1.7%
669	Corneal Scar	1.7%
670	Holoprosencephaly	1.7%
671	Prader-Willi Syndrome	1.6%
672	Muscular Dystrophy, Duchenne	1.6%
673	Phantom pain	1.6%
674	Phantom Limb Pain	1.6%
675	Retrograde amnesia	1.6%
676	Amnesia, Anterograde	1.6%
677	Corneal Perforation	1.5%
678	Fragile X Syndrome	1.3%
679	Rubinstein-Taybi Syndrome	1.2%
680	Mucopolysaccharidosis II	0.9%

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