MetaADEDB: ADE

	Name	Number of Reports	Reference(s)	Data Source
1	tofacitinib	FAERS: 367 Canada Vigilance: 1		Canada Vigilance US FAERS
2	Methotrexate	FAERS: 71 Canada Vigilance: 2		Canada Vigilance US FAERS
3	Alendronate	FAERS: 60	15637369	CTD US FAERS
4	Levofloxacin	FAERS: 47		US FAERS
5	Zoledronic Acid	FAERS: 27 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
6	rofecoxib	FAERS: 23		OFFSIDES US FAERS
7	Ciprofloxacin	FAERS: 9 Canada Vigilance: 1		Canada Vigilance US FAERS
8	Simvastatin	FAERS: 9		US FAERS
9	Isotretinoin	FAERS: 8		US FAERS
10	Sulfasalazine	FAERS: 8	2880997	CTD US FAERS
11	Lamotrigine	FAERS: 5		US FAERS
12	Methotrexate	FAERS: 5 Canada Vigilance: 3	3970039 7944624	CTD OFFSIDES Canada Vigilance US FAERS
13	Vemurafenib	FAERS: 5		US FAERS
14	Alendronate	FAERS: 4		US FAERS
15	Letrozole	FAERS: 4		OFFSIDES US FAERS
16	Methylprednisolone	FAERS: 4		OFFSIDES US FAERS
17	Tretinoin	FAERS: 4	20009973	CTD OFFSIDES US FAERS
18	Amoxicillin-Potassium Clavulanate Combination	FAERS: 3		US FAERS
19	Anastrozole	FAERS: 3		US FAERS
20	Atorvastatin	FAERS: 3		US FAERS
21	Citalopram	FAERS: 3		US FAERS
22	Fosamax plus D	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
23	Imatinib Mesylate	FAERS: 3		US FAERS
24	Methylphenidate	FAERS: 3		US FAERS
25	Ondansetron	FAERS: 3		US FAERS
26	Prednisone	FAERS: 3		US FAERS
27	eltrombopag	FAERS: 3		US FAERS
28	Betamethasone	FAERS: 2		US FAERS
29	Bupivacaine	FAERS: 2		OFFSIDES US FAERS
30	Buprenorphine	FAERS: 2		US FAERS
31	Celecoxib	FAERS: 2		SIDER US FAERS
32	Ciprofloxacin	FAERS: 2		US FAERS
33	Clofazimine	FAERS: 2		US FAERS
34	Fluoxetine	FAERS: 2		US FAERS
35	Gabapentin	FAERS: 2		US FAERS
36	Ioxaglic Acid	FAERS: 2		OFFSIDES US FAERS
37	Lopinavir	FAERS: 2		US FAERS
38	Minocycline	FAERS: 2		US FAERS
39	Mirtazapine	FAERS: 2		US FAERS
40	Moxifloxacin	FAERS: 2		US FAERS
41	Mycophenolic Acid	FAERS: 2		US FAERS
42	Pamidronate	FAERS: 2		US FAERS
43	Pregabalin	FAERS: 2		US FAERS
44	Tenofovir	FAERS: 2		US FAERS
45	Thyroxine	FAERS: 2		US FAERS
46	Triamcinolone	FAERS: 2		OFFSIDES US FAERS
47	Valproic Acid	FAERS: 2		US FAERS
48	Varenicline	FAERS: 2		US FAERS
49	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1		US FAERS
50	Amiodarone	FAERS: 1		US FAERS
51	Bupivacaine	FAERS: 1		US FAERS
52	Carbamazepine	FAERS: 1		OFFSIDES US FAERS
53	Clindamycin	FAERS: 1		US FAERS
54	Colchicine	FAERS: 1		US FAERS
55	Cyclophosphamide	FAERS: 1	3970039	CTD US FAERS
56	Diclofenac	FAERS: 1		US FAERS
57	Dimethyl Fumarate	FAERS: 1		US FAERS
58	Esomeprazole	FAERS: 1		US FAERS
59	Everolimus	FAERS: 1		OFFSIDES US FAERS
60	Ezetimibe	FAERS: 1		US FAERS
61	F8 protein, human	FAERS: 1		US FAERS
62	Fingolimod Hydrochloride	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
63	Fluoxetine	FAERS: 1		US FAERS
64	Gefitinib	FAERS: 1		US FAERS
65	Glipizide	FAERS: 1		US FAERS
66	Hydroxychloroquine	FAERS: 1		OFFSIDES US FAERS
67	Ibandronic Acid	FAERS: 1		US FAERS
68	Imatinib Mesylate	FAERS: 1		US FAERS
69	Leflunomide	FAERS: 1		OFFSIDES SIDER US FAERS
70	Liraglutide	FAERS: 1		US FAERS
71	Medroxyprogesterone Acetate	FAERS: 1		US FAERS
72	Methimazole	FAERS: 1		US FAERS
73	Methylprednisolone Acetate	FAERS: 1		US FAERS
74	Olmesartan Medoxomil	FAERS: 1		US FAERS
75	PCI 32765	FAERS: 1		US FAERS
76	Raloxifene Hydrochloride	FAERS: 1		US FAERS
77	Risedronic Acid	FAERS: 1		US FAERS
78	Terbinafine	FAERS: 1		OFFSIDES US FAERS
79	Teriparatide	FAERS: 1		US FAERS
80	Triamcinolone Acetonide	FAERS: 1		OFFSIDES US FAERS
81	Trimethoprim, Sulfamethoxazole Drug Combination	FAERS: 1		US FAERS
82	apixaban	FAERS: 1		US FAERS
83	apremilast	FAERS: 1		US FAERS
84	benzonatate	FAERS: 1		US FAERS
85	betamethasone sodium phosphate	FAERS: 1		US FAERS
86	carbidopa, levodopa drug combination	FAERS: 1		US FAERS
87	exemestane	FAERS: 1		US FAERS
88	montelukast	FAERS: 1		US FAERS
89	tofacitinib	FAERS: 1		US FAERS
90	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride			OFFSIDES
91	Acamprosate			OFFSIDES
92	Acitretin			OFFSIDES
93	Adapalene			OFFSIDES
94	Allopurinol			OFFSIDES
95	Amifostine			OFFSIDES
96	Aripiprazole			OFFSIDES
97	Ascorbic Acid			OFFSIDES
98	Azathioprine		950630 3970039	CTD
99	Beclomethasone			OFFSIDES
100	Beclomethasone			OFFSIDES
101	Bimatoprost			OFFSIDES
102	Brimonidine Tartrate			OFFSIDES
103	Bromazepam			OFFSIDES
104	Carboplatin			OFFSIDES
105	Chlorambucil		3970039	CTD
106	Chlordiazepoxide			OFFSIDES
107	Chlorhexidine		9619932	CTD OFFSIDES
108	Cisplatin			OFFSIDES
109	Deferoxamine		6830329	CTD
110	Dexamethasone			OFFSIDES
111	Diltiazem			OFFSIDES
112	Diphenoxylate			OFFSIDES
113	Dipyrone			OFFSIDES
114	Docetaxel			OFFSIDES
115	Doxorubicin			OFFSIDES
116	Ephedrine			OFFSIDES
117	Etilefrine			OFFSIDES
118	Etodolac			OFFSIDES
119	Famciclovir			OFFSIDES
120	Fentanyl			OFFSIDES SIDER
121	Fluconazole			OFFSIDES
122	Fluorouracil			OFFSIDES
123	Flurazepam			OFFSIDES
124	Flurbiprofen			OFFSIDES
125	Gatifloxacin			OFFSIDES
126	Gemfibrozil		8422571	CTD SIDER
127	Hydralazine			OFFSIDES
128	Indomethacin			OFFSIDES
129	Ivermectin			SIDER
130	Ketoconazole			OFFSIDES
131	Ketorolac			OFFSIDES
132	Ketorolac Tromethamine			OFFSIDES
133	Lansoprazole			SIDER
134	Loratadine			OFFSIDES
135	Loteprednol Etabonate			OFFSIDES
136	Meperidine			OFFSIDES
137	Meprobamate			OFFSIDES
138	Metformin			OFFSIDES
139	Metronidazole			OFFSIDES
140	Minocycline			OFFSIDES
141	Mitoxantrone			OFFSIDES
142	Morphine	Canada Vigilance: 1		Canada Vigilance OFFSIDES
143	Moxifloxacin			OFFSIDES
144	Mupirocin			OFFSIDES
145	Naproxen		6850193	CTD
146	Niacinamide			OFFSIDES
147	Nitrofurantoin	Canada Vigilance: 1		Canada Vigilance
148	NuvaRing			OFFSIDES
149	Ofloxacin			SIDER
150	Orphenadrine			OFFSIDES
151	Paclitaxel			OFFSIDES
152	Pamidronate			OFFSIDES
153	Penicillamine		290353 4014226	CTD SIDER
154	Penicillin V			OFFSIDES
155	Piperacillin, Tazobactam Drug Combination			OFFSIDES
156	Piroxicam			OFFSIDES
157	Prazosin			OFFSIDES
158	Prednisolone		24492690	CTD OFFSIDES
159	Prednisone acetate			OFFSIDES
160	Procainamide	Canada Vigilance: 1		Canada Vigilance
161	Procainamide	Canada Vigilance: 1		Canada Vigilance
162	Propylthiouracil		6850193	CTD
163	Rabeprazole			OFFSIDES
164	Raloxifene Hydrochloride			OFFSIDES
165	Sildenafil Citrate			SIDER
166	Sumatriptan			OFFSIDES
167	Tamoxifen			OFFSIDES
168	Thiamine			OFFSIDES
169	Tobramycin			OFFSIDES
170	Tramadol			OFFSIDES
171	Ubiquinone			OFFSIDES
172	Vinorelbine			OFFSIDES
173	Vitamin A			OFFSIDES
174	Zolpidem			OFFSIDES
175	benazepril			OFFSIDES
176	benoxaprofen		6789963	CTD
177	cefuroxime axetil			OFFSIDES
178	cerivastatin	Canada Vigilance: 1		Canada Vigilance
179	cevimeline			OFFSIDES SIDER
180	chlordiazepoxide, clidinium drug combination			OFFSIDES
181	chlorhexidine gluconate			OFFSIDES
182	dexpanthenol			OFFSIDES
183	dolasetron			OFFSIDES
184	ebastine			OFFSIDES
185	isosorbide-5-mononitrate			OFFSIDES
186	nefazodone			OFFSIDES
187	norgestimate, ethinyl estradiol drug combination			OFFSIDES
188	pirbuterol			OFFSIDES
189	rizatriptan			OFFSIDES
190	rizatriptan			OFFSIDES
191	ropinirole			SIDER
192	testosterone 17 beta-cypionate			OFFSIDES
193	urovision	Canada Vigilance: 1		Canada Vigilance
194	valdecoxib			SIDER
195	zolmitriptan			OFFSIDES

	Name	Semantic Similarity
1	Arthritis	42.9%
2	Bursitis	42.9%
3	Joint Instability	42.9%
4	Joint laxity	42.9%
5	Polyarthritis	42.9%
6	Frozen shoulder	42.9%
7	Patellofemoral Pain Syndrome	42.9%
8	Periarthritis	40.9%
9	Contracture	38.1%
10	Osteoarthropathy, Secondary Hypertrophic	38.1%
11	Sacroiliitis	31%
12	Ankylosing spondylitis	29.5%
13	Arthrogryposis	28.2%
14	Hemarthrosis	27.9%
15	Metatarsalgia	27.8%
16	Hip Contracture	27.3%
17	Osteoarthritis, Spine	26.7%
18	Gout	24.7%
19	Osteoarthritis, Knee	23.6%
20	Arthritis, Psoriatic	23.5%
21	Bone Diseases	23.1%
22	Fasciitis	23.1%
23	Foot Deformities	23.1%
24	Rheumatic Fever	22.2%
25	Spondylarthropathies	21.5%
26	Arthritis, Reactive	21.5%
27	Arthritis, Infectious	20.9%
28	Arthritis, Experimental	20.5%
29	Temporomandibular Joint Disorders	20.3%
30	Ischemic contracture	20.3%
31	Arthritis, Gouty	19.7%
32	Fasciitis, Plantar	19%
33	Rheumatoid Arthritis	18.1%
34	Juvenile arthritis	18.1%
35	Rheumatoid Nodule	17.5%
36	Nail-Patella Syndrome	16.7%
37	Arthralgia	16.1%
38	Polyarthralgia	16.1%
39	Temporomandibular Joint Dysfunction Syndrome	16%
40	Hip Dislocation	15.8%
41	Jaw Diseases	15.8%
42	Shoulder Dislocation	15.8%
43	Hip Dysplasia	15.8%
44	Cartilage Diseases	15%
45	Foot Diseases	15%
46	Myopathy	15%
47	Rheumatism	15%
48	Chondromalacia	15%
49	Bone Diseases, Developmental	14.3%
50	Hyperostosis	14.3%
51	Myofascial Pain Syndromes	14.3%
52	Osteitis	14.3%
53	Osteitis Deformans	14.3%
54	Osteochondrosis	14.3%
55	Rhabdomyolysis	14.3%
56	Spinal Diseases	14.3%
57	Fibromyalgia	14%
58	Osteochondritis	14%
59	Polymyalgia Rheumatica	14%
60	Felty Syndrome	14%
61	Pectus carinatum	12.6%
62	Platybasia	12.1%
63	Pectus excavatum	12.1%
64	Shoulder Pain	11.8%
65	Rheumatoid Vasculitis	11.6%
66	Klippel-Feil Syndrome	11.1%
67	Synostosis	11.1%
68	Talipes	10.9%
69	Ainhum	10.3%
70	Bunion	10.3%
71	Dysostoses	10.3%
72	Fibrodysplasia Ossificans Progressiva	10.3%
73	Myoglobinuria	10.3%
74	Myositis Ossificans	10.3%
75	Spinal Stenosis	10.3%
76	Spondylosis	10.3%
77	Tenosynovitis	10.3%
78	Intervertebral Disc Degeneration	10.3%
79	Gigantism	10.2%
80	Spinal Neoplasms	10.2%
81	Spondylitis	10.2%
82	Bone Diseases, Endocrine	10%
83	Sicca Syndrome	10%
84	Sjogren's Syndrome	10%
85	Bone Diseases, Infectious	9.5%
86	Bone neoplasms	9.5%
87	Compartment syndromes	9.5%
88	Maxillary Diseases	9.5%
89	Osteopenia	9.5%
90	Tendinitis	9.5%
91	Tendinopathy	9.5%
92	Bone Resorption	9.3%
93	Myositis	9.3%
94	Tietze's Syndrome	9.3%
95	Limb Deformities, Congenital	9.3%
96	Isaacs syndrome	9.3%
97	Craniofacial Abnormalities	9.3%
98	Aseptic Necrosis of Bone	9.3%
99	Myotonic Disorders	9.3%
100	Congenital clubfoot	9.3%
101	Vertical Talus	9.3%
102	Craniofacial Dysostosis	9.2%
103	Craniosynostosis	9.1%
104	Syndactyly	9.1%
105	Brachycephaly	9.1%
106	Chondrodysplasia Punctata	8.5%
107	Enchondromatosis	8.5%
108	Lordosis	8.5%
109	Osteosclerosis	8.5%
110	Spondylolysis	8.5%
111	kyphosis	8.5%
112	Kashin-Beck Disease	8.5%
113	Acrocephalosyndactylia	8.3%
114	Discitis	8.3%
115	Poland Syndrome	7.7%
116	Melorheostosis	7.6%
117	Osteopetrosis	7.6%
118	Spondylolisthesis	7.6%
119	Goldenhar Syndrome	7.1%
120	Medial Tibial Stress Syndrome	7%
121	Multiple Epiphyseal Dysplasia	7%
122	Osteochondrodysplasias	7%
123	Mitochondrial Myopathies	6.9%
124	Muscle Cramp	6.8%
125	Eosinophilia-Myalgia Syndrome	6.8%
126	Gastroschisis	6.8%
127	Anterior Compartment Syndrome	6.8%
128	Osteomyelitis	6.8%
129	Osteoporosis	6.8%
130	Periostitis	6.8%
131	Enthesopathy	6.8%
132	Bone Demineralization, Pathologic	6.8%
133	Post-Traumatic Osteoporosis	6.8%
134	Abdominal Compartment Syndrome	6.8%
135	Muscle Rigidity	6.8%
136	Muscle Spasticity	6.8%
137	Cogwheel Rigidity	6.8%
138	Nuchal Rigidity	6.8%
139	Alveolar Bone Loss	6.7%
140	Amelia	6.7%
141	Arachnodactyly	6.7%
142	Ectromelia	6.7%
143	Femur Head Necrosis	6.7%
144	Hemimelia	6.7%
145	Phocomelia	6.7%
146	Sirenomelia	6.7%
147	Polymyositis	6.7%
148	Polydactyly	6.7%
149	Brachydactyly	6.7%
150	Plagiocephaly	6.7%
151	Lower Extremity Deformities, Congenital	6.7%
152	Upper Extremity Deformities, Congenital	6.7%
153	Osteolysis	6.7%
154	Tuberculosis, Spinal	6.5%
155	Jaw Abnormalities	6.3%
156	Mandibulofacial Dysostosis	6.2%
157	Congenital Hypothyroidism	6.2%
158	Prognathism	6%
159	Chronic Fatigue Syndrome	5.8%
160	Antley-Bixler Syndrome Phenotype	5.8%
161	Osteoporosis, Postmenopausal	5.6%
162	Giant Cell Epulis	5.5%
163	Muscle Weakness	5.5%
164	Dwarfism	5.5%
165	Musculoskeletal Pain	5.4%
166	Familial Periodic Paralysis	5.4%
167	Muscular Dystrophy	5.1%
168	Orbital Myositis	5.1%
169	Dupuytren Contracture	5.1%
170	Pyomyositis	5%
171	Acromegaly	5%
172	Joint Tuberculosis	5%
173	Tuberculosis, Osteoarticular	5%
174	Bone Tuberculosis	5%
175	Palatal Neoplasms	5%
176	Micrognathism	4.9%
177	Pierre Robin Syndrome	4.9%
178	Laryngomalacia	4.7%
179	Rubinstein-Taybi Syndrome	4.6%
180	Myotonic Dystrophy	4.6%
181	Eosinophilic Granuloma	4.5%
182	Myalgia	4.5%
183	Retrognathia	4.3%
184	Osteogenesis Imperfecta	4.3%
185	Welander Distal Myopathy	4.1%
186	Mastoiditis	4.1%
187	Petrositis	4.1%
188	Maxillofacial Abnormalities	4.1%
189	Myotonia Congenita	4%
190	Rickets	4%
191	Bronchomalacia	4%
192	Tracheomalacia	4%
193	Microcephaly	4%
194	Macrocephaly	4%
195	Hypokalemic periodic paralysis	3.9%
196	Basal Cell Nevus Syndrome	3.6%
197	Cleft Palate	3.4%
198	Dermatomyositis	3.4%
199	Pseudohypoparathyroidism	3.3%
200	Muscular Dystrophy, Duchenne	3.3%
201	Mitochondrial Encephalomyopathies	3.3%
202	Osteomalacia	3.3%
203	Porencephaly	3.3%
204	Noonan Syndrome	2.9%
205	Marfan Syndrome	2.6%
206	Holoprosencephaly	2.5%
207	Radicular Cyst	2.4%
208	Cockayne Syndrome	2.4%
209	Nose Neoplasms	2.1%
210	Renal Osteodystrophy	2%
211	Renal rickets	2%
212	MELAS Syndrome	1.6%
213	Kearns-Sayre syndrome	1.5%
214	Familial Hypophosphatemic Rickets	1.1%