MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hemophilia A

(UMLS:C0019069)

Definition:: The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.
UMLS ID:: C0019069
MeSH ID:: D006467

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.100.100.500|C15.378.100.141.500|C15.378.463.500

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.099.500

Synonym(s)

Hemophilia A

A; hemophilia

AHG DEFICIENCY

AHG deficiency disease

ANTIHEMOPHILIC FACTOR A DEFICIENCY

ANTIHEMOPHILIC GLOBULIN DEFICIENCY

Classical haemophilia

Classical hemophilia

Congenital factor VIII deficiency

10.

Congenital factor VIII deficiency disease

11.

Congenital factor VIII disorder

12.

FACTOR VIII DISORDER CONGENITAL

13.

Factor VIII Deficiency

14.

Factor VIII deficiency

15.

HEMOPHILIA A

16.

Haemophilia A

17.

Haemophilia A, NOS

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Cyclophosphamide		11918545	CTD
2	Tranexamic Acid		11209027 12144537	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Afibrinogenemia	73.8%
2	Factor VII Deficiency	73.8%
3	Factor X Deficiency	73.8%
4	Factor XII Deficiency	73.8%
5	Factor II deficiency	73.8%
6	Factor V deficiency	73.8%
7	Factor XI Deficiency	73.8%
8	Hypoprothrombinemias	73.8%
9	Activated Protein C Resistance	67.2%
10	Thrombasthenia	64.6%
11	Disseminated Intravascular Coagulation	61.3%
12	Antithrombin III Deficiency	58%
13	Protein C Deficiency	58%
14	Thrombocythemia, Essential	56.2%
15	Protein S Deficiency	53.8%
16	Wiskott-Aldrich Syndrome	51.1%
17	Vitamin K Deficiency	46.8%
18	Anemia	32%
19	Blood Platelet Disorders	32%
20	Bone Marrow Diseases	32%
21	Leukocyte Disorders	32%
22	Methemoglobinemia	32%
23	Pancytopenia	32%
24	Polycythemia	32%
25	Sulfhemoglobinemia	32%
26	Thrombophilia	32%
27	Erythrocytosis	32%
28	Anemia, Sickle Cell	29%
29	Thalassemia	29%
30	Bone Marrow Neoplasms	28.3%
31	Thrombocytosis	27.9%
32	Transfusion Reaction	27.6%
33	Hypotensive Transfusion Reaction	27.6%
34	Pregnancy Complications, Hematologic	27%
35	Hematologic Neoplasms	27%
36	Anemia, Diamond-Blackfan	26.8%
37	Pelger-Huet Anomaly	26.7%
38	Autoimmune thrombocytopenia	26.6%
39	Immune thrombocytopenic purpura	26.6%
40	Hemophilia A	26.2%
41	Factor VIII Deficiency	26.2%
42	Purpura, Thrombotic Thrombocytopenic	26.1%
43	Polycythemia Vera	25.6%
44	Ecchymosis	25.5%
45	Petechiae	25.5%
46	Purpura	25.5%
47	Purpura, Hyperglobulinemic	25.4%
48	Hemoglobinuria, Paroxysmal	22.8%
49	Leukemoid Reaction	22.8%
50	Cryoglobulinemia	22.1%
51	Sickle Cell Trait	21.6%
52	Waldenstrom Macroglobulinemia	21.1%
53	Waterhouse-Friderichsen Syndrome	20.7%
54	Anemia, Neonatal	20%
55	Hemorrhagic Disorders	20%
56	Thrombocytopenic purpura	19.8%
57	Anemia, Hemolytic	19.7%
58	Anemia, Macrocytic	19.7%
59	Eosinophilia	19.7%
60	Hypoproteinemia	19.7%
61	Leukopenia	19.7%
62	Thrombocytopenia	19.7%
63	Leukostasis	19.7%
64	MYELODYSPLASTIC SYNDROME	19.7%
65	Lymphatic Diseases	19.2%
66	Agammaglobulinemia	19%
67	Fanconi Anemia	18.4%
68	Multiple Myeloma	17.8%
69	Acute Chest Syndrome	17.6%
70	Hydrops Fetalis	17.4%
71	Monoclonal Gammopathy of Undetermined Significance	17.2%
72	Purpura Fulminans	17.2%
73	Leukocytosis	16.7%
74	Paraproteinemias	16.7%
75	Pleocytosis	16.7%
76	Infectious Mononucleosis	16.5%
77	Chronic granulomatous disease	15.5%
78	Shwartzman Phenomenon	15.5%
79	Hemangioma, Cavernous	15.4%
80	Scurvy	15.4%
81	Hemolytic-Uremic Syndrome	15.2%
82	Pseudoxanthoma Elasticum	14.8%
83	Heavy Chain Disease	14.6%
84	Hypergammaglobulinemia	14.4%
85	Transfusion-Related Acute Lung Injury	14.2%
86	Primary Myelofibrosis	13.7%
87	Agranulocytosis	13.7%
88	Anemia, Megaloblastic	13.7%
89	Lymphocytosis	13.7%
90	Myelofibrosis	13.7%
91	Myeloid Metaplasia	13.7%
92	Hypoalbuminemia	13.7%
93	Hypereosinophilic syndrome	13.7%
94	bone marrow fibrosis	13.7%
95	Thrombotic Microangiopathies	13.7%
96	Atypical Hemolytic Uremic Syndrome	12.4%
97	Lymphatic Abnormalities	12.4%
98	Blood Coagulation Disorders	12%
99	Autoimmune Lymphoproliferative Syndrome	11.8%
100	Lymphopenia	11.6%
101	Job Syndrome	11.5%
102	Leukemia, Myelomonocytic, Chronic	11.4%
103	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	11.4%
104	Lymphangiectasis, Intestinal	11.3%
105	Kernicterus	11.3%
106	Aicardi's syndrome	11%
107	Fragile X Syndrome	10.8%
108	Neutropenia	10.7%
109	Adenitis	10.7%
110	Histiocytosis	10.7%
111	Lymphadenitis	10.7%
112	Lymphangitis	10.7%
113	Lymphedema	10.7%
114	Splenic Diseases	10.7%
115	Thymus Hyperplasia	10.7%
116	Pseudolymphoma	10.7%
117	Lymphadenopathy	10.7%
118	CHARGE Syndrome	10.5%
119	Neoplastic Syndromes, Hereditary	10.3%
120	Cystic Fibrosis	10.3%
121	Eosinophilic Granuloma	10.3%
122	POEMS Syndrome	10.2%
123	Ichthyosis, X-Linked	10.1%
124	Multiple Epiphyseal Dysplasia	10%
125	Osteochondrodysplasias	10%
126	Werner Syndrome	10%
127	Myasthenic Syndromes, Congenital	10%
128	Eosinophilia-Myalgia Syndrome	10%
129	Albinism	9.9%
130	Muscular Dystrophy, Duchenne	9.8%
131	Beckwith-Wiedemann Syndrome	9.4%
132	Wolf-Hirschhorn Syndrome	9.4%
133	Febrile Neutropenia	9.3%
134	Nail-Patella Syndrome	9.2%
135	Cockayne Syndrome	9.2%
136	Pulmonary Eosinophilia	9.1%
137	Eosinophilic Pneumonia	9.1%
138	Alstrom Syndrome	9%
139	Lymphocele	9%
140	Lymphoproliferative Disorders	9%
141	Leukemia, Myeloid, Chronic-Phase	8.9%
142	Anemia, Pernicious	8.9%
143	Thymus Neoplasms	8.9%
144	Mucopolysaccharidosis II	8.9%
145	Dwarfism	8.8%
146	Muscular Dystrophy	8.5%
147	Osteogenesis Imperfecta	8.5%
148	Rett Syndrome	8.4%
149	Menkes Kinky Hair Syndrome	8.3%
150	Smith-Magenis syndrome	8.3%
151	Cri-du-Chat Syndrome	8.2%
152	Down Syndrome	8.2%
153	Trisomy 21	8.2%
154	Kartagener Syndrome	8.1%
155	Familial Mediterranean Fever	7.9%
156	Holoprosencephaly	7.8%
157	Mucocutaneous Lymph Node Syndrome	7.6%
158	Marfan Syndrome	7.6%
159	Angioedemas, Hereditary	7.4%
160	Ectodermal Dysplasia	7.4%
161	Aplasia Cutis Congenita	7.4%
162	Prader-Willi Syndrome	7.3%
163	Smith-Lemli-Opitz Syndrome	7.2%
164	Myotonic Dystrophy	7.2%
165	Neuronal Ceroid-Lipofuscinoses	7.1%
166	Adrenoleukodystrophy	7%
167	Rubinstein-Taybi Syndrome	6.9%
168	Tuberous Sclerosis	6.9%
169	Deformity	6.8%
170	Kallmann Syndrome	6.7%
171	Sjogren-Larsson Syndrome	6.6%
172	Amino Acid Metabolism, Inborn Errors	6.6%
173	Carbohydrate Metabolism, Inborn Errors	6.6%
174	Metal Metabolism, Inborn Errors	6.6%
175	Progeria	6.6%
176	Lysosomal Storage Diseases	6.6%
177	Cytochrome-c Oxidase Deficiency	6.6%
178	Peroxisomal Disorders	6.6%
179	Elephantiasis	6.6%
180	Hypersplenism	6.6%
181	Sarcoidosis	6.6%
182	Elephantiasis Nostras Verrucosa	6.6%
183	Hepatolenticular Degeneration	6.6%
184	Polycystic Kidney Diseases	6.5%
185	Williams Syndrome	6.5%
186	Primary Ciliary Dyskinesia	6.5%
187	Refsum Disease	6.5%
188	Fabry Disease	6.4%
189	Amyloid Neuropathies, Familial	6.2%
190	Retinal Dysplasia	6%
191	Glycogen storage disease type II	6%
192	Aniridia	6%
193	Epidermolysis Bullosa	5.9%
194	Galactosemias	5.8%
195	Urea Cycle Disorders, Inborn	5.8%
196	Tyrosinemias	5.8%
197	Fetal Diseases	5.7%
198	Cutis Laxa	5.7%
199	Retinitis Pigmentosa	5.7%
200	Pigmentary retinopathy	5.7%
201	Porokeratosis	5.7%
202	Keratoderma, Palmoplantar	5.7%
203	Welander Distal Myopathy	5.6%
204	Niemann-Pick Disease, Type C	5.6%
205	Granuloma	5.6%
206	Histiocytic Disorders, Malignant	5.6%
207	Splenic Infarction	5.6%
208	Splenic Neoplasms	5.6%
209	Histiocytosis, Langerhans-Cell	5.5%
210	Tumor Lysis Syndrome	5.5%
211	Ataxia Telangiectasia	5.5%
212	Mucopolysaccharidosis III	5.4%
213	Optic Atrophy, Hereditary, Leber	5.3%
214	Hyperphosphaturia	5.3%
215	Canavan Disease	5.3%
216	Alexander Disease	5.3%
217	Sezary Syndrome	5.2%
218	Zellweger Syndrome	5.1%
219	Duane Retraction Syndrome	5%
220	Porphyrias, Hepatic	5%
221	Gaucher Disease	5%
222	Peutz-Jeghers Syndrome	4.9%
223	Myotonia Congenita	4.9%
224	Brain Diseases, Metabolic, Inborn	4.9%
225	Classical Lissencephalies and Subcortical Band Heterotopias	4.9%
226	Dystonia Musculorum Deformans	4.9%
227	Alkaptonuria	4.9%
228	Glycogen Storage Disease	4.9%
229	Hypophosphatasia	4.9%
230	Propionic acidemia	4.9%
231	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
232	Cystinosis	4.9%
233	Homocystinuria	4.9%
234	Lafora Disease	4.9%
235	Unverricht-Lundborg Syndrome	4.9%
236	Leigh Disease	4.9%
237	Polycystic Kidney, Autosomal Dominant	4.9%
238	Splenic Rupture	4.8%
239	Lymphoma	4.8%
240	Thymoma	4.7%
241	Hyperkeratosis, Epidermolytic	4.7%
242	Lymphohistiocytosis, Hemophagocytic	4.6%
243	Erdheim-Chester Disease	4.6%
244	Tay-Sachs Disease	4.5%
245	Meconium Aspiration Syndrome	4.5%
246	Multiple Endocrine Neoplasia	4.5%
247	Xeroderma Pigmentosum	4.4%
248	Congenital Hypothyroidism	4.4%
249	Dermatitis, Atopic	4.4%
250	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.4%
251	Charcot-Marie-Tooth Disease	4.3%
252	Antley-Bixler Syndrome Phenotype	4.3%
253	Hypolipoproteinemias	4.2%
254	Papillon-Lefevre Disease	4.2%
255	Hyperlipidemia, Familial Combined	4.2%
256	Hyperlipoproteinemia Type III	4.2%
257	Xeroderma	4.2%
258	Mobius Syndrome	4.2%
259	Glycogen Storage Disease Type I	4.1%
260	Glycogen Storage Disease Type V	4.1%
261	Basal Cell Nevus Syndrome	4%
262	Abdominal Cramps	4%
263	Abnormalities, Drug-Induced	4%
264	Amniotic Band Syndrome	4%
265	Asphyxia Neonatorum	4%
266	Infant, Premature, Diseases	4%
267	Situs Inversus	4%
268	Infantile Colic	4%
269	Behcet Syndrome	4%
270	Malignant histiocytosis	3.8%
271	Sarcoidosis, Pulmonary	3.8%
272	Histiocytic sarcoma	3.8%
273	Familial Periodic Paralysis	3.7%
274	Klinefelter Syndrome	3.7%
275	Lactose Intolerance	3.7%
276	Variegate Porphyria	3.7%
277	Acute intermittent porphyria	3.7%
278	Porphyria Cutanea Tarda	3.7%
279	Hyperhomocysteinemia	3.7%
280	Renal Aminoacidurias	3.7%
281	Fanconi Syndrome	3.7%
282	Pseudohypoaldosteronism	3.7%
283	Liddle Syndrome	3.7%
284	Hyperlipoproteinemia Type IV	3.6%
285	Hyperlipoproteinemia Type V	3.6%
286	Huntington Disease	3.6%
287	Hypoalphalipoproteinemias	3.5%
288	Eye Abnormalities	3.4%
289	Cardiovascular Abnormalities	3.4%
290	Turner Syndrome	3.4%
291	Skin Abnormalities	3.4%
292	Congenital Microtia	3.4%
293	Persistent Fetal Circulation Syndrome	3.3%
294	Congenital diaphragmatic hernia	3.3%
295	Gout	3.3%
296	Umbilical hernia	3.3%
297	Anencephaly	3.3%
298	Splenosis	3.3%
299	Multiple Endocrine Neoplasia Type 1	3.3%
300	Pseudohypoparathyroidism	3.3%
301	Nephroblastoma	3.3%
302	Hodgkin Disease	3.3%
303	Lymphoma, Non-Hodgkin	3.3%
304	Leukemia, T-Cell	3.3%
305	Leukemia, B-Cell	3.3%
306	Friedreich Ataxia	3.3%
307	Renal tubular acidosis	3.2%
308	Hypokalemic periodic paralysis	3%
309	Cystinuria	3%
310	Adenomatous Polyposis Coli	3%
311	Familial Hypophosphatemic Rickets	3%
312	Urogenital Abnormalities	3%
313	Neonatal Abstinence Syndrome	2.9%
314	Maxillofacial Abnormalities	2.9%
315	Dural Arteriovenous Fistula	2.9%
316	Dextrocardia	2.9%
317	Composite Lymphoma	2.9%
318	Fetal Growth Retardation	2.9%
319	Lymphangioleiomyomatosis	2.8%
320	Fetal Hypoxia	2.8%
321	Congenital nystagmus	2.8%
322	Fetal Alcohol Spectrum Disorders	2.8%
323	Toxoplasmosis, Congenital	2.8%
324	Syphilis, Congenital	2.8%
325	Arthritis, Gouty	2.7%
326	Glycosuria, Renal	2.6%
327	Prune Belly Syndrome	2.6%
328	Twins, Conjoined	2.6%
329	Waardenburg Syndrome	2.6%
330	Lymphoma, Follicular	2.5%
331	T-Cell Lymphoma	2.5%
332	Mantle cell lymphoma	2.5%
333	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
334	Leukemia, Large Granular Lymphocytic	2.5%
335	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
336	Congenital Hyperinsulinism	2.5%
337	Chorioamnionitis	2.5%
338	Scimitar Syndrome	2.4%
339	Denys-Drash Syndrome	2.3%
340	Acrocephalosyndactylia	2.3%
341	Microcephaly	2.2%
342	Macrocephaly	2.2%
343	MELAS Syndrome	2.2%
344	Anophthalmos	2.2%
345	Anus, Imperforate	2.2%
346	Hydranencephaly	2.2%
347	Microphthalmos	2.2%
348	Neural Tube Defects	2.2%
349	Paralysis, Obstetric	2.2%
350	Retinopathy of Prematurity	2.2%
351	Tethered Cord Syndrome	2.2%
352	Iniencephaly	2.2%
353	Craniorachischisis	2.2%
354	Limb Deformities, Congenital	2.2%
355	Exencephaly	2.2%
356	Septo-Optic Dysplasia	2.2%
357	Craniofacial Abnormalities	2.2%
358	Cortical Dysplasia	2.2%
359	Malformations of Cortical Development	2.2%
360	Anorectal Malformations	2.2%
361	Abnormalities, Radiation-Induced	2.2%
362	Bloom Syndrome	2.2%
363	Lymphoma, T-Cell, Cutaneous	2.2%
364	Lymphoma, AIDS-Related	2.2%
365	Enteropathy-Associated T-Cell Lymphoma	2.2%
366	Primary Effusion Lymphoma	2.2%
367	Bronchopulmonary Dysplasia	2.2%
368	Craniosynostosis	2.2%
369	Syndactyly	2.2%
370	Brachycephaly	2.2%
371	Porencephaly	2%
372	Mycosis Fungoides	2%
373	Lymphomatoid Papulosis	2%
374	Plasmablastic lymphoma	2%
375	Noonan Syndrome	2%
376	Ophthalmia Neonatorum	2%
377	Cleft Palate	1.9%
378	Lymphomatoid Granulomatosis	1.9%
379	Blepharophimosis	1.9%
380	Laryngostenosis	1.9%
381	Mouth Abnormalities	1.9%
382	Respiratory Distress Syndrome, Newborn	1.9%
383	Esophageal Atresia	1.9%
384	Intestinal Atresia	1.9%
385	Horseshoe Kidney	1.9%
386	Pectus excavatum	1.9%
387	Klippel-Feil Syndrome	1.9%
388	Gastroschisis	1.9%
389	Synostosis	1.9%
390	Acrodermatitis	1.9%
391	Gianotti-Crosti Syndrome	1.9%
392	Jaw Abnormalities	1.8%
393	Poland Syndrome	1.8%
394	Burkitt Lymphoma	1.7%
395	Arthrogryposis	1.7%
396	Choanal Atresia	1.7%
397	Tracheobronchomegaly	1.7%
398	Laryngocele	1.7%
399	Choledochal Cyst	1.7%
400	Hermaphroditism	1.7%
401	Disorders of Sex Development	1.7%
402	Cryptorchidism	1.7%
403	Hypospadias	1.7%
404	Central Nervous System Cysts	1.7%
405	Dandy-Walker Syndrome	1.7%
406	Amelia	1.6%
407	Arachnodactyly	1.6%
408	Ectopia Cordis	1.6%
409	Ectromelia	1.6%
410	Hemimelia	1.6%
411	Leukomalacia, Periventricular	1.6%
412	Meningomyelocele	1.6%
413	Phocomelia	1.6%
414	Sirenomelia	1.6%
415	Spina Bifida	1.6%
416	Polydactyly	1.6%
417	Brachydactyly	1.6%
418	Plagiocephaly	1.6%
419	Lower Extremity Deformities, Congenital	1.6%
420	Upper Extremity Deformities, Congenital	1.6%
421	Single umbilical artery	1.6%
422	Nesidioblastosis	1.6%
423	Micrognathism	1.5%
424	Pierre Robin Syndrome	1.5%
425	Laryngomalacia	1.5%
426	Pectus carinatum	1.5%
427	Bladder Exstrophy	1.5%
428	Epispadias	1.5%
429	Multicystic Dysplastic Kidney	1.5%
430	Aortic coarctation	1.4%
431	Cor Triatriatum	1.4%
432	Coronary Vessel Anomalies	1.4%
433	Dental Enamel Hypoplasia	1.4%
434	Patent ductus arteriosus	1.4%
435	Ebstein Anomaly	1.4%
436	Heart Septal Defects	1.4%
437	Hyaline Membrane Disease	1.4%
438	Hypodontia	1.4%
439	Macrostomia	1.4%
440	Meningocele	1.4%
441	Microstomia	1.4%
442	Tetralogy of Fallot	1.4%
443	Transposition of Great Vessels	1.4%
444	Hypoplastic Left Heart Syndrome	1.4%
445	May-Thurner Syndrome	1.4%
446	Encephalocele	1.4%
447	Retrognathia	1.4%
448	Craniofacial Dysostosis	1.4%
449	Wolff-Parkinson-White Syndrome	1.4%
450	Dermal Sinus	1.4%
451	Spina Bifida Cystica	1.4%
452	Spina Bifida Occulta	1.4%
453	Lissencephaly	1.4%
454	Polymicrogyria	1.4%
455	Pachygyria	1.4%
456	Schizencephaly	1.4%
457	Periventricular Nodular Heterotopia	1.4%
458	Hyperandrogenism	1.3%
459	Prognathism	1.3%
460	Long QT Syndrome	1.2%
461	Platybasia	1.2%
462	Tricuspid Atresia	1.2%
463	Arrhythmogenic Right Ventricular Dysplasia	1.2%
464	Gonadal Dysgenesis	1.2%
465	Bronchomalacia	1.2%
466	Adrenogenital Syndrome	1.2%
467	Tracheomalacia	1.2%
468	Ovotesticular Disorders of Sex Development	1.2%
469	Aortopulmonary Septal Defect	1.2%
470	Double Outlet Right Ventricle	1.2%
471	Endocardial Cushion Defects	1.2%
472	Myocardial bridging	1.2%
473	Aorticopulmonary Septal Defect	1.2%
474	Truncus Arteriosus, Persistent	1%
475	Goldenhar Syndrome	1%
476	Mandibulofacial Dysostosis	1%
477	Romano-Ward Syndrome	1%
478	Talipes	0.9%
479	Congenital clubfoot	0.9%
480	Vertical Talus	0.9%
481	Arteriovenous fistula	0.8%

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