MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Motor Neuron Disease

(UMLS:C0085084)

Definition:: Diseases characterized by a selective degeneration of the motor neurons of the spinal cord, brainstem, or motor cortex. Clinical subtypes are distinguished by the major site of degeneration. In AMYOTROPHIC LATERAL SCLEROSIS there is involvement of upper, lower, and brainstem motor neurons. In progressive muscular atrophy and related syndromes (see MUSCULAR ATROPHY, SPINAL) the motor neurons in the spinal cord are primarily affected. With progressive bulbar palsy (BULBAR PALSY, PROGRESSIVE), the initial degeneration occurs in the brainstem. In primary lateral sclerosis, the cortical neurons are affected in isolation. (Adams et al., Principles of Neurology, 6th ed, p1089)
UMLS ID:: C0085084
MeSH ID:: D016472

Classification:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.574.562|C10.668.467

Synonym(s)

Motor Neuron Disease

Disease;motor neuron

MND - Motor neurone disease

MOTOR SYSTEM DISEASE

Motor neuron disease

Motor neuron disease or syndrome

Motor neuron disease, NOS

Motor neuron disease, unspecified

Motor neurone disease

10.

Motor neurons--Diseases

11.

degenerative motor system disease

12.

disease motor neuron

13.

disease motor neurone

14.

disease motor neurones

15.

disease motor neurons

16.

motor neuron disease

17.

motor neuron diseases

18.

motor neurone disease

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Acrylamide	29524570	CTD
2	Baclofen	18385632	CTD
3	Dapsone	9251603	CTD
4	Deferoxamine	9149744	CTD
5	Dexamethasone	14518677	CTD
6	Dichlorvos	11282359	CTD
7	Doxorubicin	2456816	CTD
8	Edaravone	26469273	CTD
9	Methamphetamine	17453645	CTD
10	Methotrexate	11241435	CTD
11	Nitric Oxide	7885422	CTD
12	Pancuronium	8403681	CTD
13	Phenytoin	856594	CTD
14	Progesterone	22486171	CTD
15	Rotenone	17367952	CTD
16	Sodium Selenite	24406377	CTD
17	Vincristine	10390891 11241435	CTD
18	calpeptin	29524570	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Prion Diseases	38.6%
2	Neuromuscular Junction Diseases	38.1%
3	Tauopathies	38.1%
4	Peripheral Nervous System Diseases	38.1%
5	Multiple System Atrophy	37.7%
6	Causalgia	35.1%
7	Complex Regional Pain Syndromes	35.1%
8	Stiff-Person Syndrome	34.9%
9	Parkinson Disease	34.8%
10	Brachial Plexus Neuritis	33.9%
11	Neuralgic Amyotrophy	33.9%
12	Tarsal Tunnel Syndrome	32.1%
13	Cauda Equina Syndrome	32.1%
14	Guillain-Barre Syndrome	31.7%
15	Polyradiculoneuropathy	30.1%
16	Polyradiculoneuritis	30.1%
17	Cranial nerve diseases	30%
18	Demyelinating Diseases	30%
19	Demyelination	30%
20	Chronobiology Disorders	30%
21	Myopathy	29.6%
22	Striatonigral Degeneration	29.5%
23	Subacute Combined Degeneration	29.4%
24	Lewy Body Disease	29.4%
25	Poliomyelitis	29.4%
26	Peripheral Nerve Injuries	28.2%
27	Neuritis	27.9%
28	Polyneuritis	27.9%
29	Radiculitis	27.9%
30	Polyneuropathy	27.9%
31	Mononeuritis	27.9%
32	Mononeuropathies	27.9%
33	Brachial Plexus Neuropathies	27.9%
34	Radiculopathy	27.9%
35	Mononeuropathy Multiplex	27.9%
36	Nerve Root Compression	27.9%
37	Myasthenia Gravis	27.8%
38	Reflex Sympathetic Dystrophy	27.4%
39	Lambert-Eaton Myasthenic Syndrome	27.2%
40	Chronic Fatigue Syndrome	26.5%
41	Miller Fisher Syndrome	26.2%
42	Carpal Tunnel Syndrome	25.6%
43	Sciatica	25.3%
44	Shy-Drager Syndrome	25.3%
45	Myotonia Congenita	24.9%
46	Dystonia Musculorum Deformans	24.7%
47	Meningoencephalitis	24.7%
48	Encephalomyelitis	24.6%
49	Autonomic Dysreflexia	24.6%
50	Progressive supranuclear palsy	24.4%
51	Cubital Tunnel Syndrome	24%
52	Charcot-Marie-Tooth Disease	23.8%
53	Ocular Motility Disorders	23.5%
54	Cyclophoria	23.5%
55	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	23.5%
56	Scrapie	23.4%
57	Amyotrophic Lateral Sclerosis	23.2%
58	Presenile dementia	23.1%
59	Senile dementia	23.1%
60	Trauma, Nervous System	23.1%
61	Myotonic Dystrophy	23%
62	Sciatic Neuropathy	23%
63	Ulnar Neuropathies	23%
64	Lesion of Sciatic Nerve	23%
65	Ulnar Neuritis	23%
66	Radial nerve compression	23%
67	Radial Tunnel Syndrome	23%
68	Peroneal Neuropathies	23%
69	Radial Neuropathy	23%
70	Median Neuropathy	23%
71	Sciatic Nerve Palsy	23%
72	Femoral Neuropathy	23%
73	Tibial Neuropathy	23%
74	Ulnar Nerve Palsy	23%
75	Radial nerve palsy	23%
76	Acrodynia	22.9%
77	Botulism	22.9%
78	Restless Legs Syndrome	22.8%
79	Myelitis, Transverse	22.7%
80	Ophthalmoplegic Migraine	22.6%
81	Marchiafava-Bignami Disease	22.6%
82	Paraneoplastic Encephalomyelitis	22.5%
83	Lafora Disease	22.5%
84	Unverricht-Lundborg Syndrome	22.5%
85	Nervous System Neoplasms	22.2%
86	Neurologic Manifestations	22.2%
87	Neurotoxicity Syndromes	22.2%
88	Opsoclonus-Myoclonus Syndrome	21.8%
89	Myositis	21.1%
90	Isaacs syndrome	21.1%
91	Limbic Encephalitis	21.1%
92	Myotonic Disorders	21.1%
93	Myasthenic Syndromes, Congenital	21.1%
94	Diabetic Neuropathies	20.7%
95	Myelitis	20.7%
96	Diabetic Amyotrophy	20.7%
97	Diabetic Autonomic Neuropathy	20.7%
98	Polyradiculopathy	20.6%
99	Neuralgia	20.5%
100	Neuropathic pain	20.5%
101	Dandy-Walker Syndrome	20.5%
102	Pneumocephalus	20.3%
103	Spinal Cord Injuries	20.3%
104	Leukoencephalitis, Acute Hemorrhagic	20.2%
105	Huntington Disease	19.7%
106	Asterixis	19.4%
107	Ballismus	19.4%
108	Epidural Abscess	19.1%
109	Olfactory Nerve Injuries	19.1%
110	Paraneoplastic Cerebellar Degeneration	19.1%
111	Brain Diseases	19%
112	Dysautonomia	19%
113	Meningitis	19%
114	Movement Disorders	19%
115	Pachymeningitis	19%
116	Spinal Cord Diseases	19%
117	Vagus Nerve Disorder	19%
118	Glossopharyngeal Neuralgia	19%
119	Abducens Nerve Diseases	19%
120	Heavy Metal Poisoning, Nervous System	19%
121	Trochlear Nerve Diseases	19%
122	MPTP Poisoning	18.9%
123	Subdural Effusion	18.8%
124	Parkinsonian Disorders	18.8%
125	Nocturnal Myoclonus Syndrome	18.8%
126	neurofibroma	18.7%
127	Friedreich Ataxia	18.5%
128	Encephalomyelitis, Acute Disseminated	18.5%
129	Myasthenia Gravis, Autoimmune, Experimental	18.3%
130	Neuroleptic Malignant Syndrome	17.9%
131	Myelinolysis, Central Pontine	17.9%
132	Neuromyelitis Optica	17.9%
133	Sleep Wake Disorders	17.9%
134	Neuritis, Autoimmune, Experimental	17.9%
135	Canavan Disease	17.6%
136	Alexander Disease	17.6%
137	Thoracic Outlet Syndrome	17.4%
138	Hand-Arm Vibration Syndrome	17.4%
139	Polymyositis	17.1%
140	Meige Syndrome	16.9%
141	Cerebral Ventriculitis	16.9%
142	Fibromyalgia	16.9%
143	Medial Tibial Stress Syndrome	16.9%
144	Epilepsy, Post-Traumatic	16.7%
145	Mitochondrial Myopathies	16.7%
146	Sleep Disorders, Circadian Rhythm	16.7%
147	Eosinophilia-Myalgia Syndrome	16.6%
148	Spinal Muscular Atrophy	16.4%
149	Brain Injuries	16.4%
150	Progressive Muscular Atrophy	16.4%
151	Facial Nerve Injuries	16.3%
152	Brain Neoplasms	16.3%
153	Multiple Sclerosis	16.3%
154	Spinal Cord Neoplasms	16.3%
155	Dyskinesia, Drug-Induced	16.2%
156	Amyloid Neuropathies, Familial	16.2%
157	Leukoencephalopathy, Progressive Multifocal	16.1%
158	Posterior Leukoencephalopathy Syndrome	16%
159	Posterior reversible encephalopathy syndrome	16%
160	Frontotemporal dementia	16%
161	Central Nervous System Cysts	16%
162	Tuberous Sclerosis	15.6%
163	Cerebellar Neoplasms	15.4%
164	Central Cord Syndrome	15.2%
165	Myoclonic Epilepsy	15.1%
166	Epilepsy, Temporal Lobe	15.1%
167	Epilepsy, Rolandic	15.1%
168	Benign Rolandic Epilepsy	15.1%
169	Alstrom Syndrome	15%
170	Neuromuscular Diseases	15%
171	Meningitis, Bacterial	15%
172	Meningitis, Fungal	15%
173	Lupus Vasculitis, Central Nervous System	14.9%
174	Chorea	14.9%
175	Refsum Disease	14.9%
176	Central Nervous System Infection	14.8%
177	Optic Neuropathy	14.8%
178	Horner Syndrome	14.7%
179	Mitochondrial Encephalomyopathies	14.4%
180	Facial Nerve Diseases	14.3%
181	Craniocerebral Trauma	14.3%
182	Parasomnia	14.3%
183	Motor Neuron Disease	14.3%
184	Dyssomnias	14.3%
185	Juvenile Myoclonic Epilepsy	14.2%
186	Myoclonic Epilepsies, Progressive	14.2%
187	Dementia, Vascular	14.1%
188	Hepatolenticular Degeneration	14%
189	Brain Hemorrhage, Traumatic	14%
190	Vestibulocochlear Nerve Diseases	14%
191	Decerebrate State	14%
192	Hemiparesis	14%
193	Hydranencephaly	14%
194	Meningism	14%
195	Neural Tube Defects	14%
196	Paresis	14%
197	Seizures	14%
198	Sensation Disorders	14%
199	Tethered Cord Syndrome	14%
200	Central Nervous System Neoplasms	14%
201	Complex partial seizures	14%
202	Iniencephaly	14%
203	Craniorachischisis	14%
204	Exencephaly	14%
205	Monoparesis	14%
206	Septo-Optic Dysplasia	14%
207	Cortical Dysplasia	14%
208	Neurogenic Inflammation	14%
209	Gait Disorders, Neurologic	14%
210	Neuromuscular Manifestations	14%
211	Malformations of Cortical Development	14%
212	Akinetic Mutism	14%
213	Anoxic Encephalopathy	14%
214	Arachnoiditis	14%
215	Basal Ganglia Diseases	14%
216	Brain Damage, Chronic	14%
217	Cerebellar Diseases	14%
218	Encephalitis	14%
219	Encephalomalacia	14%
220	Epilepsy	14%
221	Hydrocephalus	14%
222	Congenital Hydrocephalus	14%
223	Hypothalamic Diseases	14%
224	Aseptic Meningitis	14%
225	Syringomyelia	14%
226	Thalamic Diseases	14%
227	Intracranial Hypertension	14%
228	Aura	14%
229	Leukoencephalopathy	14%
230	Essential Tremor	14%
231	Neuroaxonal Dystrophies	14%
232	Familial Tremor	14%
233	Headache Disorders	14%
234	Intracranial Hypotension	14%
235	Brain Edema	14%
236	Brain Hypoxia	14%
237	Aqueductal Stenosis	14%
238	Pneumorrhachis	14%
239	Writer's Cramp	14%
240	Sweating, Gustatory	13.9%
241	Auriculotemporal Syndrome	13.9%
242	Brain Death	13.9%
243	Coma, Post-Head Injury	13.9%
244	Muscular Dystrophy	13.8%
245	Orbital Myositis	13.8%
246	Akathisia, Drug-Induced	13.8%
247	Brain Abscess	13.7%
248	Ophthalmoplegia	13.7%
249	External Ophthalmoplegia	13.7%
250	Familial Periodic Paralysis	13.6%
251	Pyomyositis	13.6%
252	Creutzfeldt-Jakob disease	13.5%
253	Basal Ganglia Cerebrovascular Disease	13.5%
254	Brain Injuries, Diffuse	13.4%
255	Traumatic Brain Injury	13.4%
256	Cerebellar Ataxia	13.4%
257	Supratentorial Neoplasms	13.4%
258	Torticollis	13.4%
259	Multiple Sclerosis, Chronic Progressive	13.4%
260	Multiple Sclerosis, Relapsing-Remitting	13.4%
261	Tuberculosis, Meningeal	13.2%
262	Vascular Headaches	12.8%
263	Hypoxia-Ischemia, Brain	12.7%
264	Vasculitis, Central Nervous System	12.7%
265	Tardive Dyskinesia	12.7%
266	Persistent Vegetative State	12.6%
267	Jet Lag Syndrome	12.6%
268	Ataxia Telangiectasia	12.5%
269	Amblyopia	12.5%
270	Carotid Artery Injuries	12.4%
271	Cerebrospinal Fluid Otorrhea	12.3%
272	Cerebrospinal Fluid Rhinorrhea	12.3%
273	Gait Ataxia	12.3%
274	Neurofibrosarcoma	12.1%
275	Welander Distal Myopathy	12.1%
276	Diffuse Axonal Injury	12%
277	Brain Stem Neoplasms	11.9%
278	Vocal Cord Paralysis	11.8%
279	Alice in Wonderland Syndrome	11.7%
280	Pituitary Adenoma	11.7%
281	Pituitary Neoplasms	11.7%
282	Pupil Disorders	11.6%
283	Neurobehavioral Manifestations	11.6%
284	Myalgia	11.6%
285	Brain Concussion	11.5%
286	Cerebral Palsy	11.5%
287	Epilepsies, Partial	11.5%
288	Epilepsy, Generalized	11.5%
289	Pseudotumor Cerebri	11.5%
290	Hypertensive Encephalopathy	11.5%
291	Simple Partial Seizures	11.5%
292	Epilepsy, Reflex	11.5%
293	Postural Orthostatic Tachycardia Syndrome	11.5%
294	Headache Disorders, Primary	11.5%
295	Headache Disorders, Secondary	11.5%
296	Medication overuse headache	11.5%
297	Neuronal Ceroid-Lipofuscinoses	11.4%
298	Leukomalacia, Periventricular	11.2%
299	POEMS Syndrome	11.2%
300	Choroid Plexus Papilloma	11.2%
301	Uveomeningoencephalitic Syndrome	11.1%
302	Hypokalemic periodic paralysis	11.1%
303	Sturge-Weber Syndrome	11%
304	Vertigo	11%
305	Alcohol-Induced Disorders, Nervous System	11%
306	Basal Ganglia Hemorrhage	10.8%
307	MELAS Syndrome	10.7%
308	Optic Atrophy, Hereditary, Leber	10.7%
309	Toxoplasmosis, Cerebral	10.7%
310	Meningitis, Cryptococcal	10.6%
311	Optic Nerve Glioma	10.6%
312	Brain Diseases, Metabolic	10.5%
313	Cerebrovascular Disorders	10.5%
314	Meningitis, Listeria	10.5%
315	Optic Atrophy	10.5%
316	Optic Neuritis	10.5%
317	Papilledema	10.5%
318	Strabismus	10.5%
319	Tolosa-Hunt Syndrome	10.5%
320	Cerebrovascular Insufficiency	10.5%
321	Arsenic Poisoning	10.5%
322	Dementia	10.5%
323	Central Nervous System Fungal Infections	10.5%
324	Conus Medullaris Syndrome	10.5%
325	Spinal Cord Vascular Diseases	10.5%
326	Akathisia	10.5%
327	Restlessness	10.5%
328	Psychomotor Agitation	10.5%
329	Meningitis, Haemophilus	10.5%
330	Meningitis, Pneumococcal	10.5%
331	Facial Injuries	10.3%
332	Facial Neuralgia	10.3%
333	Progressive bulbar palsy	10.3%
334	Sleep Talking	10.3%
335	Manganese Poisoning	10.3%
336	Sleep Disorders, Intrinsic	10.3%
337	Orthostatic intolerance	10.3%
338	Bulbar palsy	10.3%
339	Dermatomyositis	10.3%
340	Post-Traumatic Headache	10.3%
341	Tension Headache	10.3%
342	Epilepsy, Complex Partial	10.3%
343	Migraine Disorders	10.3%
344	Abdominal Migraine	10.3%
345	Status Migrainosus	10.3%
346	Cervicogenic Headache	10.3%
347	Anosmia	10.3%
348	Ataxia	10.3%
349	Athetosis	10.3%
350	Catalepsy	10.3%
351	Dystonia	10.3%
352	Hemiplegia	10.3%
353	Locked-In Syndrome	10.3%
354	Meningeal Neoplasms	10.3%
355	Meningomyelocele	10.3%
356	Muscle Hypertonia	10.3%
357	Muscle hypotonia	10.3%
358	Myoclonus	10.3%
359	Myotonia	10.3%
360	Paraplegia	10.3%
361	Pseudobulbar Palsy	10.3%
362	Quadriplegia	10.3%
363	Spasm	10.3%
364	Spastic Paraplegia	10.3%
365	Status Epilepticus	10.3%
366	Taste Disorders	10.3%
367	Tremor	10.3%
368	Spina Bifida	10.3%
369	Monoplegia	10.3%
370	Hypokinesia	10.3%
371	Paraparesis	10.3%
372	Bradykinesia	10.3%
373	Waxy flexibility	10.3%
374	Action Tremor	10.3%
375	Resting Tremor	10.3%
376	Dysosmia	10.3%
377	Quadriparesis	10.3%
378	Mercury Poisoning, Nervous System	10.3%
379	Olfaction Disorders	10.3%
380	Myokymia	10.3%
381	Lead Poisoning, Nervous System	10.3%
382	Vestibular Neuronitis	10.3%
383	Somatosensory Disorders	10.3%
384	Hyperkinesia	10.3%
385	Intention tremor	10.3%
386	Putaminal Hemorrhage	10.2%
387	Infarction, Middle Cerebral Artery	10.1%
388	Infarction, Anterior Cerebral Artery	10.1%
389	Infarction, Posterior Cerebral Artery	10.1%
390	Cockayne Syndrome	10.1%
391	Pituitary Apoplexy	10.1%
392	Muscular Dystrophy, Duchenne	10.1%
393	Vertebral Artery Dissection	10%
394	Alcohol Withdrawal Seizures	10%
395	Amnesia, Transient Global	10%
396	Brain Contusion	10%
397	Brain Infarction	9.9%
398	Gait Apraxia	9.9%
399	Subacute Sclerosing Panencephalitis	9.9%
400	Kearns-Sayre syndrome	9.8%
401	Subarachnoid Hemorrhage, Traumatic	9.8%
402	Carotid Artery, Internal, Dissection	9.8%
403	Cluster Headache	9.7%
404	Migraine with Aura	9.7%
405	Familial Hemiplegic Migraine	9.7%
406	Chronic Paroxysmal Hemicrania	9.7%
407	SUNCT Syndrome	9.7%
408	Paroxysmal Hemicrania	9.7%
409	Voice Disorders	9.4%
410	Voice Disturbance	9.4%
411	Cerebral Infarction	9.3%
412	Brain Stem Infarctions	9.3%
413	Smith-Magenis syndrome	9.2%
414	Dural Arteriovenous Fistula	9.1%
415	Pituitary Diseases	9%
416	Lateral Medullary Syndrome	9%
417	Classical Lissencephalies and Subcortical Band Heterotopias	8.9%
418	Adrenoleukodystrophy	8.6%
419	Carotid Artery Diseases	8.5%
420	Brain Ischemia	8.5%
421	Esotropia	8.5%
422	Exotropia	8.5%
423	Hypotension, Orthostatic	8.5%
424	Sleep Apnea Syndromes	8.5%
425	Cerebrovascular accident	8.5%
426	Kluver-Bucy Syndrome	8.5%
427	Vasospasm, Intracranial	8.5%
428	Spinal Cord Ischemia	8.5%
429	Intracranial Arterial Diseases	8.5%
430	Post-Exercise Hypotension	8.5%
431	Vision Disorders	8.5%
432	Metamorphopsia	8.5%
433	Visual Impairment	8.5%
434	Disorders of Excessive Somnolence	8.5%
435	Sleep Initiation and Maintenance Disorders	8.5%
436	Night Terrors	8.5%
437	Somnambulism	8.5%
438	Trigeminal Nerve Disorder	8.5%
439	Transient Insomnia	8.5%
440	Sleep Paralysis	8.5%
441	Chronic Insomnia	8.5%
442	REM Sleep Behavior Disorder	8.5%
443	Hypersomnia	8.5%
444	Alexia	8.5%
445	Dyslexia	8.5%
446	Optic Neuropathy, Ischemic	8.5%
447	Anterior Ischemic Optic Neuropathy	8.5%
448	Central Nervous System Bacterial Infections	8.5%
449	Dermal Sinus	8.4%
450	Dysgeusia	8.4%
451	Formication	8.4%
452	Hyperalgesia	8.4%
453	Hyperesthesia	8.4%
454	Hypesthesia	8.4%
455	Language Disorders	8.4%
456	Numbness	8.4%
457	Paresthesia	8.4%
458	Paraparesis, Spastic	8.4%
459	Spina Bifida Cystica	8.4%
460	Trismus	8.4%
461	Spina Bifida Occulta	8.4%
462	Epilepsia Partialis Continua	8.4%
463	Hypogeusia	8.4%
464	Meningeal Carcinomatosis	8.4%
465	Brown-Sequard Syndrome	8.4%
466	Lissencephaly	8.4%
467	Polymicrogyria	8.4%
468	Pachygyria	8.4%
469	Schizencephaly	8.4%
470	Lockjaw	8.4%
471	Allodynia	8.4%
472	Lead Poisoning, Nervous System, Childhood	8.4%
473	Lead Poisoning, Nervous System, Adult	8.4%
474	Periventricular Nodular Heterotopia	8.4%
475	Ageusia	8.4%
476	Tuberculosis, Central Nervous System	8.4%
477	Facial Hemiatrophy	8.3%
478	Melkersson-Rosenthal Syndrome	8.3%
479	West Nile Fever	8.3%
480	Auditory Perceptual Disorders	8.3%
481	Anisocoria	8.3%
482	Confusion	8.3%
483	Facial paralysis	8.3%
484	Lethargy	8.3%
485	Memory Disorders	8.3%
486	Muscle Cramp	8.3%
487	Perceptual Disorders	8.3%
488	Psychomotor Disorders	8.3%
489	Tonic Pupil	8.3%
490	Anhedonia	8.3%
491	Disorientation	8.3%
492	Facial Paresis	8.3%
493	Memory Loss	8.3%
494	Hemisensory Neglect	8.3%
495	Dysacusis	8.3%
496	Moyamoya Disease	8.3%
497	Sleep Bruxism	8.2%
498	Anencephaly	8.2%
499	Meningocele	8.2%
500	Muscular Atrophy	8.2%
501	Respiratory Paralysis	8.2%
502	Encephalocele	8.2%
503	Tetany	8.1%
504	Empty Sella Syndrome	7.8%
505	Hyperpituitarism	7.8%
506	Hypopituitarism	7.8%
507	Hypophysitis	7.8%
508	Giant Cell Arteritis	7.7%
509	Temporal Arteritis	7.7%
510	Reflex, Abnormal	7.7%
511	Hyporeflexia	7.7%
512	Hyperreflexia	7.7%
513	Hematoma, Subdural	7.6%
514	Hematoma, Epidural, Cranial	7.6%
515	Cerebral Arterial Diseases	7.6%
516	Vertebrobasilar Insufficiency	7.6%
517	Anterior Spinal Artery Syndrome	7.6%
518	Basilar Artery Stenosis	7.6%
519	Vertebral Artery Stenosis	7.6%
520	Sleep Apnea, Obstructive	7.6%
521	Sleep Apnea, Central	7.6%
522	Intracranial Hemorrhage, Hypertensive	7.6%
523	Transient Cerebral Ischemia	7.6%
524	Narcolepsy	7.6%
525	Trigeminal Neuralgia	7.6%
526	Kleine-Levin Syndrome	7.6%
527	Agraphia	7.5%
528	Anomia	7.5%
529	Cluttering	7.5%
530	Language Development Disorders	7.5%
531	Speech Disorders	7.5%
532	Syncope	7.5%
533	Stupor	7.5%
534	Dysgraphia	7.5%
535	Presyncope	7.5%
536	Dyslalia	7.5%
537	Hyperprolactinemia	7.2%
538	Acoustic Neuroma	7.2%
539	Subclavian Steal Syndrome	7.1%
540	Pick Disease of the Brain	7.1%
541	Cataplexy	7.1%
542	Aphasia	7.1%
543	Articulation Disorders	7.1%
544	Echolalia	7.1%
545	Stuttering	7.1%
546	Dysphasia	7.1%
547	Eye Injuries	7%
548	Hematoma, Subdural, Intracranial	7%
549	Hematoma, Subdural, Chronic	7%
550	Hematoma, Subdural, Acute	7%
551	Duane Retraction Syndrome	7%
552	Consciousness Disorders	6.9%
553	Mental Retardation	6.9%
554	Muscle Weakness	6.9%
555	Depressed Level of Consciousness	6.9%
556	Mental deficiency	6.9%
557	Intellectual Disability	6.9%
558	Mobius Syndrome	6.9%
559	Bell Palsy	6.9%
560	Congenital nystagmus	6.9%
561	Dysarthria	6.9%
562	Catatonia	6.9%
563	Herpes Zoster Oticus	6.8%
564	Diplopia	6.8%
565	Muscle Rigidity	6.8%
566	Muscle Spasticity	6.8%
567	Scotoma	6.8%
568	Photophobia	6.8%
569	Cogwheel Rigidity	6.8%
570	Hemifacial Spasm	6.8%
571	Amaurosis	6.8%
572	Blindness	6.8%
573	Nuchal Rigidity	6.8%
574	Reye Syndrome	6.8%
575	Neuroaspergillosis	6.8%
576	Aphonia	6.8%
577	Sleep Deprivation	6.8%
578	Dysphonia	6.8%
579	Intracranial Embolism and Thrombosis	6.8%
580	Hepatic Encephalopathy	6.8%
581	Agnosia	6.7%
582	Apraxias	6.7%
583	Hallucinations	6.7%
584	Hemianopsia	6.7%
585	Hyperacusis	6.7%
586	Tinnitus	6.7%
587	Visual Agnosia	6.7%
588	Anosognosia	6.7%
589	Wernicke-Korsakoff Syndrome	6.7%
590	Phonophobia	6.7%
591	Hearing Loss	6.7%
592	Sarcopenia	6.7%
593	Toxoplasmosis, Congenital	6.1%
594	Eye Burns	6.1%
595	Malaria, Cerebral	6.1%
596	Carotid Stenosis	6.1%
597	Intracranial Aneurysm	6.1%
598	Neurocysticercosis	6%
599	Amaurosis Fugax	6%
600	Blindness, Cortical	6%
601	Dyscalculia	6%
602	Intracranial Arteriosclerosis	6%
603	Cerebral Atherosclerosis	6%
604	Rett Syndrome	6%
605	Subarachnoid Hemorrhage	6%
606	Cerebral Arteriosclerosis	6%
607	Cerebral Hemorrhage	6%
608	Cerebral Thrombosis	6%
609	Intracranial Embolism	6%
610	Intracranial Thrombosis	6%
611	Deafness	6%
612	Hearing Loss, Sudden	6%
613	Gerstmann Syndrome	6%
614	Hearing Loss, Bilateral	6%
615	Hearing Loss, High-Frequency	6%
616	Hearing Loss, Mixed Conductive-Sensorineural	6%
617	Prosopagnosia	6%
618	Apraxia, Ideomotor	6%
619	Charles Bonnet Syndrome	6%
620	Hearing Loss, Unilateral	6%
621	Complete Hearing Loss	6%
622	Alien Hand Syndrome	6%
623	Deaf Mutism	6%
624	Pseudorabies	5.9%
625	Mutism	5.8%
626	Selective Mutism	5.8%
627	Acromegaly	5.8%
628	Amnesia	5.7%
629	Delirium	5.7%
630	Dissociative Amnesia	5.7%
631	Color blindness	5.7%
632	Global Amnesia	5.7%
633	Cerebral Amyloid Angiopathy	5.7%
634	Cri-du-Chat Syndrome	5.6%
635	Down Syndrome	5.6%
636	Brain Diseases, Metabolic, Inborn	5.6%
637	Trisomy 21	5.6%
638	Sinus Thrombosis, Intracranial	5.6%
639	Meningioma	5.6%
640	Williams Syndrome	5.6%
641	Microcephaly	5.6%
642	Macrocephaly	5.6%
643	Neurosyphilis	5.6%
644	Porencephaly	5.5%
645	Alexia, Pure	5.5%
646	Cavernous Sinus Thrombosis	5.4%
647	Sagittal Sinus Thrombosis	5.4%
648	Waterhouse-Friderichsen Syndrome	5.2%
649	Aicardi's syndrome	5.2%
650	Corneal Scar	5.1%
651	Hoarseness	5.1%
652	Alcohol Withdrawal Delirium	5%
653	Retrograde amnesia	5%
654	Amnesia, Anterograde	5%
655	Carotid Artery Thrombosis	5%
656	Menkes Kinky Hair Syndrome	4.9%
657	Prader-Willi Syndrome	4.8%
658	Wernicke Encephalopathy	4.8%
659	AIDS Dementia Complex	4.8%
660	Phantom pain	4.7%
661	Phantom Limb Pain	4.7%
662	Corneal Perforation	4.7%
663	Lyme Neuroborreliosis	4.7%
664	Nelson Syndrome	4.5%
665	Holoprosencephaly	4.5%
666	Fragile X Syndrome	4.3%
667	Kernicterus	4.3%
668	Prolactinoma	4.1%
669	Growth Hormone-Secreting Pituitary Adenoma	4.1%
670	Fabry Disease	4%
671	Rubinstein-Taybi Syndrome	3.7%
672	Galactosemias	3.7%
673	Urea Cycle Disorders, Inborn	3.7%
674	Tyrosinemias	3.7%
675	Homocystinuria	3.3%
676	Leigh Disease	3.3%
677	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.1%
678	Mucopolysaccharidosis II	2.9%
679	Glycogen storage disease type II	2.8%
680	Zellweger Syndrome	2.5%
681	Gaucher Disease	2.4%
682	Tay-Sachs Disease	2.3%
683	Niemann-Pick Disease, Type C	2.2%

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