MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Glycogen Storage Disease

(UMLS:C0017919)

Definition:: A group of inherited metabolic disorders involving the enzymes responsible for the synthesis and degradation of glycogen. In some patients, prominent liver involvement is presented. In others, more generalized storage of glycogen occurs, sometimes with prominent cardiac involvement.
UMLS ID:: C0017919
MeSH ID:: D006008

Classification 1:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.565.202.449

Classification 2:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.648.202.449

Synonym(s)

Glycogen Storage Disease

GSD - Glycogen storage disease

Gierke

Glycogen storage disease

Glycogen storage disease, NOS

Glycogen storage disease, unspecified

Glycogen storage disorder

Glycogenosis

Glycogenosis, NOS

10.

disease glycogen storage

11.

diseases glycogen storage

12.

disorders glycogen storage

13.

glycogen storage disease

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Diazoxide		4299224	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Galactosemias	37.8%
2	Lactose Intolerance	37.3%
3	Amino Acid Metabolism, Inborn Errors	34.4%
4	Metal Metabolism, Inborn Errors	34.4%
5	Progeria	34.4%
6	Lysosomal Storage Diseases	34.4%
7	Peroxisomal Disorders	34.4%
8	Leigh Disease	31.5%
9	Mucopolysaccharidosis III	30.1%
10	Brain Diseases, Metabolic, Inborn	27.9%
11	Smith-Lemli-Opitz Syndrome	26.3%
12	Mucopolysaccharidosis II	25%
13	Urea Cycle Disorders, Inborn	24.9%
14	Tyrosinemias	24.9%
15	Cytochrome-c Oxidase Deficiency	24.6%
16	Alkaptonuria	22.6%
17	Hypophosphatasia	22.6%
18	Propionic acidemia	22.6%
19	Dihydropyrimidine Dehydrogenase Deficiency	22.6%
20	Cystinosis	22.6%
21	Hyperphosphaturia	22.2%
22	Hypolipoproteinemias	21.9%
23	Pseudohypoparathyroidism	21.5%
24	Hyperlipidemia, Familial Combined	20.9%
25	Hyperhomocysteinemia	20.6%
26	Hyperlipoproteinemia Type III	20.4%
27	Werner Syndrome	20%
28	Menkes Kinky Hair Syndrome	19.9%
29	Homocystinuria	19.8%
30	Carbamoyl-Phosphate Synthase I Deficiency Disease	19.7%
31	Hyperlipoproteinemia Type IV	18.9%
32	Hyperlipoproteinemia Type V	18.9%
33	Hepatolenticular Degeneration	17.9%
34	Adrenoleukodystrophy	17.8%
35	Zellweger Syndrome	17.7%
36	Gaucher Disease	17.5%
37	Refsum Disease	17.4%
38	Wasting Syndrome	16.9%
39	Albinism	16.8%
40	Acid-Base Imbalance	16.7%
41	Calcium Metabolism Disorders	16.7%
42	Iron Metabolism Disorders	16.7%
43	Neuronal Ceroid-Lipofuscinoses	16.7%
44	Phosphorus Metabolism Disorders	16.7%
45	Water-Electrolyte Imbalance	16.7%
46	Lipid Metabolism Disorders	16.7%
47	Mitochondrial Diseases	16.7%
48	Glucose Metabolism Disorders	16.7%
49	Amyloid Neuropathies, Familial	16.5%
50	Hypoalphalipoproteinemias	16.3%
51	Fabry Disease	15.8%
52	Renal tubular acidosis	15.6%
53	Familial Periodic Paralysis	15.4%
54	Ichthyosis, X-Linked	15.1%
55	Renal Aminoacidurias	15%
56	Fanconi Syndrome	15%
57	Pseudohypoaldosteronism	15%
58	Liddle Syndrome	15%
59	Glycogen storage disease type II	14.8%
60	Hypercalcemia	14.8%
61	Hypocalcemia	14.8%
62	Milk-Alkali Syndrome	14.8%
63	Tay-Sachs Disease	14.6%
64	Niemann-Pick Disease, Type C	14.3%
65	Antley-Bixler Syndrome Phenotype	13.9%
66	Familial Hypophosphatemic Rickets	13.9%
67	Gout	13.2%
68	Neoplastic Syndromes, Hereditary	13.2%
69	Osteopenia	12.7%
70	Brain Diseases, Metabolic	12.5%
71	Multiple Epiphyseal Dysplasia	12.5%
72	Osteochondrodysplasias	12.5%
73	Pelger-Huet Anomaly	12.5%
74	Myasthenic Syndromes, Congenital	12.5%
75	Cockayne Syndrome	12.3%
76	Glycosuria, Renal	12.1%
77	Sjogren-Larsson Syndrome	12.1%
78	CHARGE Syndrome	12%
79	Lipodystrophy	11.8%
80	Cystic Fibrosis	11.5%
81	Hypokalemic periodic paralysis	11.3%
82	MELAS Syndrome	11.2%
83	Cystinuria	11.2%
84	Canavan Disease	11.1%
85	Alexander Disease	11.1%
86	Rickets	10.5%
87	Deformity	10.5%
88	Nutrition Disorders	10.5%
89	Aicardi's syndrome	10.5%
90	Dwarfism	10.4%
91	Nail-Patella Syndrome	10.1%
92	Porphyrias, Hepatic	10%
93	Muscular Dystrophy	9.9%
94	Osteogenesis Imperfecta	9.9%
95	Beckwith-Wiedemann Syndrome	9.9%
96	Wolf-Hirschhorn Syndrome	9.9%
97	Bloom Syndrome	9.8%
98	Anemia, Sickle Cell	9.8%
99	Thalassemia	9.8%
100	Acidosis	9.8%
101	Alkalosis	9.8%
102	Amyloidosis	9.8%
103	Calcinosis	9.8%
104	Hyperglycemia	9.8%
105	Hyperinsulinism	9.8%
106	Hyperkalemia	9.8%
107	Hypernatremia	9.8%
108	Hypoglycemia	9.8%
109	Hypokalemia	9.8%
110	Hyponatremia	9.8%
111	Familial Mediterranean Fever	9.8%
112	Xanthomatosis	9.8%
113	Hypophosphatemia	9.8%
114	Metabolic acidosis	9.8%
115	Dyslipidemias	9.8%
116	Iron Overload	9.8%
117	Xanthoma	9.8%
118	Muscular Dystrophy, Duchenne	9.8%
119	Fanconi Anemia	9.7%
120	Arthritis, Gouty	9.7%
121	Congenital Hyperinsulinism	9.4%
122	Fragile X Syndrome	9.2%
123	Ataxia Telangiectasia	8.9%
124	Autoimmune Lymphoproliferative Syndrome	8.4%
125	Smith-Magenis syndrome	8.3%
126	Cri-du-Chat Syndrome	8.2%
127	Down Syndrome	8.2%
128	Angioedemas, Hereditary	8.2%
129	Trisomy 21	8.2%
130	Prader-Willi Syndrome	7.9%
131	Fetal Diseases	7.9%
132	Diabetes Mellitus	7.8%
133	Rett Syndrome	7.7%
134	Optic Atrophy, Hereditary, Leber	7.6%
135	Dehydration	7.5%
136	Lipomatosis	7.5%
137	Water Intoxication	7.5%
138	Marfan Syndrome	7.4%
139	Alstrom Syndrome	7.4%
140	Achlorhydria	7.4%
141	Osteoporosis	7.4%
142	Bone Demineralization, Pathologic	7.4%
143	Post-Traumatic Osteoporosis	7.4%
144	Wiskott-Aldrich Syndrome	7.4%
145	Celiac Disease	7.3%
146	Sprue, Tropical	7.3%
147	Steatorrhea	7.3%
148	Sprue	7.3%
149	Ectodermal Dysplasia	7.1%
150	Aplasia Cutis Congenita	7.1%
151	Osteomalacia	7%
152	Xeroderma Pigmentosum	7%
153	Mitochondrial Encephalomyopathies	7%
154	Holoprosencephaly	6.9%
155	Friedreich Ataxia	6.9%
156	Kartagener Syndrome	6.9%
157	Diabetic Ketoacidosis	6.8%
158	Kallmann Syndrome	6.7%
159	Myotonic Dystrophy	6.5%
160	Polycystic Kidney Diseases	6.5%
161	Williams Syndrome	6.5%
162	Nesidioblastosis	6.5%
163	Variegate Porphyria	6.5%
164	Acute intermittent porphyria	6.5%
165	Porphyria Cutanea Tarda	6.5%
166	Acidosis, Lactic	6.5%
167	Calciphylaxis	6.5%
168	Hemosiderosis	6.5%
169	Ketosis	6.5%
170	Ketonuria	6.5%
171	Ketoacidosis	6.5%
172	Ketonemia	6.5%
173	Vascular calcification	6.5%
174	Primary Ciliary Dyskinesia	6.4%
175	Sickle Cell Trait	6.4%
176	Rubinstein-Taybi Syndrome	6.2%
177	Cutis Laxa	6%
178	Mitochondrial Myopathies	6%
179	Tuberous Sclerosis	6%
180	Retinitis Pigmentosa	6%
181	Myelinolysis, Central Pontine	6%
182	Pigmentary retinopathy	6%
183	Porokeratosis	5.9%
184	Keratoderma, Palmoplantar	5.9%
185	Glycosuria	5.9%
186	Chronic granulomatous disease	5.9%
187	Reye Syndrome	5.9%
188	Hepatic Encephalopathy	5.8%
189	Retinal Dysplasia	5.8%
190	Welander Distal Myopathy	5.8%
191	Aniridia	5.8%
192	Epidermolysis Bullosa	5.7%
193	HIV Wasting Syndrome	5.6%
194	Abdominal Cramps	5.6%
195	Abnormalities, Drug-Induced	5.6%
196	Amniotic Band Syndrome	5.6%
197	Asphyxia Neonatorum	5.6%
198	Child Nutrition Disorders	5.6%
199	Hypervitaminosis A	5.6%
200	Infant Nutrition Disorders	5.6%
201	Infant, Premature, Diseases	5.6%
202	Situs Inversus	5.6%
203	Malnutrition	5.6%
204	Infantile Colic	5.6%
205	Duane Retraction Syndrome	5.1%
206	Kernicterus	5%
207	Acute Chest Syndrome	4.9%
208	Peutz-Jeghers Syndrome	4.9%
209	Myotonia Congenita	4.9%
210	Thrombasthenia	4.9%
211	Antithrombin III Deficiency	4.9%
212	Necrobiosis Lipoidica Diabeticorum	4.9%
213	Protein C Deficiency	4.9%
214	Afibrinogenemia	4.9%
215	Dystonia Musculorum Deformans	4.9%
216	Factor VII Deficiency	4.9%
217	Factor X Deficiency	4.9%
218	Factor XII Deficiency	4.9%
219	Hemophilia A	4.9%
220	Activated Protein C Resistance	4.9%
221	Factor II deficiency	4.9%
222	Factor VIII Deficiency	4.9%
223	Factor V deficiency	4.9%
224	Factor XI Deficiency	4.9%
225	Hypoprothrombinemias	4.9%
226	Acidosis, Respiratory	4.9%
227	Adiposis Dolorosa	4.9%
228	Alkalosis, Respiratory	4.9%
229	Meconium Aspiration Syndrome	4.9%
230	HIV-Associated Lipodystrophy Syndrome	4.8%
231	Lafora Disease	4.8%
232	Unverricht-Lundborg Syndrome	4.8%
233	Insulin Resistance	4.8%
234	Osteoporosis, Postmenopausal	4.8%
235	Anemia, Diamond-Blackfan	4.8%
236	Hypercholesterolemia	4.8%
237	Hyperlipoproteinemias	4.8%
238	Hypertriglyceridemia	4.8%
239	Wernicke Encephalopathy	4.7%
240	Renal Osteodystrophy	4.7%
241	Renal rickets	4.7%
242	Xeroderma	4.4%
243	Mobius Syndrome	4.4%
244	Pseudoxanthoma Elasticum	4.4%
245	Eye Abnormalities	4.4%
246	Cardiovascular Abnormalities	4.4%
247	Multiple Endocrine Neoplasia	4.4%
248	Polycystic Kidney, Autosomal Dominant	4.3%
249	Congenital Hypothyroidism	4.3%
250	Dermatitis, Atopic	4.2%
251	Skin Abnormalities	4.2%
252	Lymphatic Abnormalities	4.2%
253	Congenital Microtia	4.2%
254	Anemia, Neonatal	4.2%
255	Persistent Fetal Circulation Syndrome	4.2%
256	Congenital diaphragmatic hernia	4.1%
257	Umbilical hernia	4.1%
258	Gestational Diabetes	4%
259	Latent Autoimmune Diabetes in Adults	4%
260	Classical Lissencephalies and Subcortical Band Heterotopias	4%
261	Diabetes Mellitus, Experimental	4%
262	Nephrocalcinosis	3.9%
263	Tetany	3.9%
264	Papillon-Lefevre Disease	3.9%
265	Cerebral Amyloid Angiopathy	3.8%
266	Hyperkeratosis, Epidermolytic	3.8%
267	Behcet Syndrome	3.7%
268	Charcot-Marie-Tooth Disease	3.7%
269	Kearns-Sayre syndrome	3.6%
270	Basal Cell Nevus Syndrome	3.6%
271	Urogenital Abnormalities	3.5%
272	Neonatal Abstinence Syndrome	3.4%
273	Fetal Growth Retardation	3.3%
274	Fetal Hypoxia	3.3%
275	Congenital nystagmus	3.3%
276	Fetal Alcohol Spectrum Disorders	3.3%
277	Toxoplasmosis, Congenital	3.3%
278	Primary amyloidosis	3.3%
279	Anencephaly	3.3%
280	Syphilis, Congenital	3.3%
281	Huntington Disease	3.3%
282	Deficiency Diseases	3.3%
283	Prune Belly Syndrome	3.3%
284	Starvation	3.3%
285	Twins, Conjoined	3.3%
286	Refeeding Syndrome	3.3%
287	Waardenburg Syndrome	3.3%
288	Nephroblastoma	2.9%
289	Amyotrophic Lateral Sclerosis	2.8%
290	Multiple Endocrine Neoplasia Type 1	2.8%
291	Chorioamnionitis	2.8%
292	Maxillofacial Abnormalities	2.8%
293	Dural Arteriovenous Fistula	2.8%
294	Hydrops Fetalis	2.7%
295	Dextrocardia	2.7%
296	Klinefelter Syndrome	2.7%
297	Adenomatous Polyposis Coli	2.6%
298	Anophthalmos	2.5%
299	Anus, Imperforate	2.5%
300	Hydranencephaly	2.5%
301	Microphthalmos	2.5%
302	Neural Tube Defects	2.5%
303	Paralysis, Obstetric	2.5%
304	Retinopathy of Prematurity	2.5%
305	Tethered Cord Syndrome	2.5%
306	Iniencephaly	2.5%
307	Craniorachischisis	2.5%
308	Limb Deformities, Congenital	2.5%
309	Exencephaly	2.5%
310	Septo-Optic Dysplasia	2.5%
311	Craniofacial Abnormalities	2.5%
312	Cortical Dysplasia	2.5%
313	Malformations of Cortical Development	2.5%
314	Anorectal Malformations	2.5%
315	Bronchopulmonary Dysplasia	2.4%
316	CREST Syndrome	2.4%
317	Frontotemporal dementia	2.4%
318	Turner Syndrome	2.4%
319	Abnormalities, Radiation-Induced	2.4%
320	Kwashiorkor	2.2%
321	Magnesium Deficiency	2.2%
322	Potassium Deficiency	2.2%
323	Protein Deficiency	2.2%
324	Avitaminosis	2.2%
325	Scimitar Syndrome	2.1%
326	Ophthalmia Neonatorum	2%
327	Blepharophimosis	2%
328	Laryngostenosis	2%
329	Mouth Abnormalities	2%
330	Respiratory Distress Syndrome, Newborn	2%
331	Esophageal Atresia	2%
332	Intestinal Atresia	2%
333	Horseshoe Kidney	2%
334	Pectus excavatum	2%
335	Klippel-Feil Syndrome	2%
336	Gastroschisis	2%
337	Synostosis	2%
338	Acrodermatitis	2%
339	Lymphangiectasis, Intestinal	2%
340	Gianotti-Crosti Syndrome	2%
341	Microcephaly	1.9%
342	Macrocephaly	1.9%
343	Craniosynostosis	1.9%
344	Syndactyly	1.9%
345	Brachycephaly	1.9%
346	Denys-Drash Syndrome	1.7%
347	Arthrogryposis	1.7%
348	Choanal Atresia	1.7%
349	Tracheobronchomegaly	1.7%
350	Laryngocele	1.7%
351	Choledochal Cyst	1.7%
352	Hermaphroditism	1.7%
353	Disorders of Sex Development	1.7%
354	Cryptorchidism	1.7%
355	Hypospadias	1.7%
356	Central Nervous System Cysts	1.7%
357	Noonan Syndrome	1.7%
358	Dandy-Walker Syndrome	1.6%
359	Leukomalacia, Periventricular	1.6%
360	POEMS Syndrome	1.6%
361	Amelia	1.6%
362	Arachnodactyly	1.6%
363	Ectopia Cordis	1.6%
364	Ectromelia	1.6%
365	Hemimelia	1.6%
366	Meningomyelocele	1.6%
367	Phocomelia	1.6%
368	Sirenomelia	1.6%
369	Spina Bifida	1.6%
370	Polydactyly	1.6%
371	Brachydactyly	1.6%
372	Plagiocephaly	1.6%
373	Lower Extremity Deformities, Congenital	1.6%
374	Upper Extremity Deformities, Congenital	1.6%
375	Single umbilical artery	1.6%
376	Obesity	1.6%
377	Ascorbic Acid Deficiency	1.6%
378	Vitamin A Deficiency	1.6%
379	Vitamin D Deficiency	1.6%
380	Vitamin E Deficiency	1.6%
381	Marasmus	1.6%
382	Porencephaly	1.6%
383	Acrocephalosyndactylia	1.6%
384	Laryngomalacia	1.5%
385	Jaw Abnormalities	1.4%
386	Pectus carinatum	1.4%
387	Bladder Exstrophy	1.4%
388	Epispadias	1.4%
389	Multicystic Dysplastic Kidney	1.4%
390	Cleft Palate	1.4%
391	Poland Syndrome	1.4%
392	Folic Acid Deficiency	1.3%
393	Pellagra	1.3%
394	Thiamine Deficiency	1.3%
395	Vitamin B 12 Deficiency	1.3%
396	Vitamin B 6 Deficiency	1.3%
397	Pyridoxine Deficiency	1.3%
398	Aortic coarctation	1.3%
399	Cor Triatriatum	1.3%
400	Coronary Vessel Anomalies	1.3%
401	Dental Enamel Hypoplasia	1.3%
402	Patent ductus arteriosus	1.3%
403	Ebstein Anomaly	1.3%
404	Heart Septal Defects	1.3%
405	Hyaline Membrane Disease	1.3%
406	Hypodontia	1.3%
407	Macrostomia	1.3%
408	Meningocele	1.3%
409	Microstomia	1.3%
410	Tetralogy of Fallot	1.3%
411	Transposition of Great Vessels	1.3%
412	Hypoplastic Left Heart Syndrome	1.3%
413	May-Thurner Syndrome	1.3%
414	Encephalocele	1.3%
415	Craniofacial Dysostosis	1.3%
416	Wolff-Parkinson-White Syndrome	1.3%
417	Obesity, Abdominal	1.3%
418	Dermal Sinus	1.2%
419	Spina Bifida Cystica	1.2%
420	Spina Bifida Occulta	1.2%
421	Lissencephaly	1.2%
422	Polymicrogyria	1.2%
423	Pachygyria	1.2%
424	Schizencephaly	1.2%
425	Periventricular Nodular Heterotopia	1.2%
426	Beriberi	1.2%
427	Micrognathism	1.1%
428	Pierre Robin Syndrome	1.1%
429	Long QT Syndrome	1.1%
430	Platybasia	1.1%
431	Tricuspid Atresia	1.1%
432	Arrhythmogenic Right Ventricular Dysplasia	1.1%
433	Gonadal Dysgenesis	1.1%
434	Bronchomalacia	1.1%
435	Adrenogenital Syndrome	1.1%
436	Tracheomalacia	1.1%
437	Ovotesticular Disorders of Sex Development	1.1%
438	Pediatric Obesity	1.1%
439	Retrognathia	1%
440	Vitamin K Deficiency	1%
441	Aortopulmonary Septal Defect	1%
442	Double Outlet Right Ventricle	1%
443	Endocardial Cushion Defects	1%
444	Myocardial bridging	1%
445	Aorticopulmonary Septal Defect	1%
446	Hyperandrogenism	1%
447	Anemia, Pernicious	0.9%
448	Prognathism	0.9%
449	Scurvy	0.8%
450	Mandibulofacial Dysostosis	0.8%
451	Romano-Ward Syndrome	0.8%
452	Truncus Arteriosus, Persistent	0.8%
453	Goldenhar Syndrome	0.8%
454	Talipes	0.7%
455	Arteriovenous fistula	0.6%
456	Congenital clubfoot	0.6%
457	Vertical Talus	0.6%
458	Subacute Combined Degeneration	0.5%

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