MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hyperkalemia

(UMLS:C0020461)

Definition:: Abnormally high potassium concentration in the blood, most often due to defective renal excretion. It is characterized clinically by electrocardiographic abnormalities (elevated T waves and depressed P waves, and eventually by atrial asystole). In severe cases, weakness and flaccid paralysis may occur. (Dorland, 27th ed)
UMLS ID:: C0020461
MeSH ID:: D006947

Classification:

Name:

Nutritional and Metabolic Diseases
MeSH Tree Number(s):: C18.452.950.396

Synonym(s)

Hyperkalemia

Elevated serum potassium levels

HYPERKALAEMIA

HYPERKALEMIA

HYPERPOTASSEMIA

Hyperkalaemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Albuterol	2384735 6114774	CTD
2	Amiloride	2770099 3188359 7365313	CTD
3	Amoxicillin	10405561	CTD
4	Atenolol	8606734	CTD
5	Azathioprine	8606734	CTD
6	Carteolol	1979694	CTD
7	Cocaine	2790454 10869388 11971848	CTD
8	Cyclophosphamide	4833837	CTD
9	Cyclosporine	3892345 8606734	CTD
10	Dantrolene	375768 6711841	CTD
11	Diclofenac	11123398 15752411	CTD
12	Digoxin	1997018 16032632	CTD
13	Diltiazem	1979694 3120959	CTD
14	Dobutamine	1979694	CTD
15	Enalapril	View details 2849806 3022272 3022372 3036457 8579032 8606734 11045392 11161080	CTD
16	Epinephrine	1032269	CTD
17	Eplerenone	14688507 17117244 21384875	CTD
18	Fludrocortisone	3375885	CTD
19	Furosemide	1605901 8606734	CTD
20	Glucose	20466255	CTD
21	Glycerol	11046231	CTD
22	Halothane	3742323 8069990	CTD
23	Heroin	11971848	CTD
24	Ibuprofen	3689062	CTD
25	Indomethacin	View details 3362274 3375885 3560096 4071154 6814155 7017180 7033849 7411769 8203268	CTD
26	Isosorbide Dinitrate	3120959	CTD
27	Ketorolac	8575131	CTD
28	Ketorolac Tromethamine	7942813 8481061	CTD
29	Lisinopril	11176729 20112435	CTD
30	Losartan	14646368 19708228	CTD
31	Magnesium Sulfate	17876916	CTD
32	Metformin	15752411	CTD
33	Methicillin	25018	CTD
34	Methylprednisolone	12653264	CTD
35	Metoprolol	12671332	CTD
36	Mitomycin	9152802	CTD
37	Naloxone	2790454	CTD
38	Naproxen	3358393 3375885	CTD
39	Nifedipine	8606734	CTD
40	Pentamidine	1763529 2773964	CTD
41	Piroxicam	6602576	CTD
42	Potassium	1605901 4814187 8045663	CTD
43	Potassium Chloride	View details 3188359 3662713 16286062 17587605	CTD
44	Prednisone	4833837 8606734	CTD
45	Promethazine	10548178	CTD
46	Propofol	16432122 16443524 17000843	CTD
47	Propranolol	16286062	CTD
48	Ramipril	12671332 20859899	CTD
49	Ranitidine	3120959	CTD
50	Sevoflurane	18947162	CTD
51	Sirolimus	15102967	CTD
52	Sodium Bicarbonate	11499566	CTD
53	Spironolactone	View details 1103606 2849806 2993981 4740303 4814187 4951338 7433326 11250985 12869459 15632880 15811903 16286062 17309946 20859899 21130975	CTD
54	Succinylcholine	View details 362143 375768 687036 1113381 1632545 2252206 2339807 3202305 3742323 3826795 4025876 4251064 4257717 4658260 4900057 5059102 5062119 5115035 5780735 6322557 6476500 6744092 7605002 7802286 8010431 8069990 8678230 8710011 8811784 9339098 9352784 9506489 9587734 9874866 10773516 11374616 11585084 12701553 15567650 16435216 16950383 17273116 17876916 18947162	CTD
55	Sulindac	3560096	CTD
56	Tacrolimus	7679825 8732602 9193849	CTD
57	Thiopental	6322557 12209290	CTD
58	Trimethoprim, Sulfamethoxazole Drug Combination	8244201 8943491 9776424	CTD
59	Trimethoprim	8124180	CTD
60	Valsartan	16285075 19100416	CTD
61	Verapamil	6711841 8021338 8852497	CTD
62	Vincristine	4833837	CTD
63	alvocidib	17906454	CTD
64	candesartan	16285075	CTD
65	cerivastatin	11733637	CTD
66	furotriam	3121011	CTD
67	gemcitabine	11733637	CTD
68	hexacarbacholine bromide	714847	CTD
69	liposomal amphotericin B	4015077 19011270	CTD
70	reviparin	View details 10624973 10726030 11975115 15875438	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hypernatremia	46.7%
2	Hypokalemia	46.7%
3	Hyponatremia	46.7%
4	Hypercalcemia	44.4%
5	Hypocalcemia	44.4%
6	Milk-Alkali Syndrome	44.4%
7	Dehydration	31.8%
8	Water Intoxication	31.8%
9	Acid-Base Imbalance	31%
10	Calcium Metabolism Disorders	31%
11	Iron Metabolism Disorders	31%
12	Phosphorus Metabolism Disorders	31%
13	Lipid Metabolism Disorders	31%
14	Mitochondrial Diseases	31%
15	Glucose Metabolism Disorders	31%
16	Wasting Syndrome	27.9%
17	Osteopenia	20.9%
18	Brain Diseases, Metabolic	20.5%
19	Acidosis	20%
20	Alkalosis	20%
21	Amyloidosis	20%
22	Calcinosis	20%
23	Hyperglycemia	20%
24	Hyperinsulinism	20%
25	Hypoglycemia	20%
26	Lipodystrophy	20%
27	Xanthomatosis	20%
28	Hypophosphatemia	20%
29	Metabolic acidosis	20%
30	Dyslipidemias	20%
31	Iron Overload	20%
32	Xanthoma	20%
33	Nutrition Disorders	18.5%
34	Pseudohypoparathyroidism	18.1%
35	Rickets	17.3%
36	Brain Diseases, Metabolic, Inborn	15.9%
37	Leigh Disease	15.2%
38	Hyperhomocysteinemia	15.1%
39	Acidosis, Lactic	14.8%
40	Calciphylaxis	14.8%
41	Hemosiderosis	14.8%
42	Ketosis	14.8%
43	Ketonuria	14.8%
44	Ketoacidosis	14.8%
45	Ketonemia	14.8%
46	Vascular calcification	14.8%
47	Hypolipoproteinemias	14.6%
48	Hyperlipoproteinemia Type IV	14.5%
49	Hyperlipoproteinemia Type V	14.5%
50	Diabetes Mellitus	14.3%
51	Carbamoyl-Phosphate Synthase I Deficiency Disease	13.8%
52	Lactose Intolerance	13.7%
53	Lipomatosis	13.6%
54	Werner Syndrome	13.6%
55	Diabetic Ketoacidosis	13.5%
56	Hyperlipidemia, Familial Combined	13.4%
57	Achlorhydria	13.3%
58	Amino Acid Metabolism, Inborn Errors	13.3%
59	Bloom Syndrome	13.3%
60	Carbohydrate Metabolism, Inborn Errors	13.3%
61	Metal Metabolism, Inborn Errors	13.3%
62	Osteoporosis	13.3%
63	Progeria	13.3%
64	Lysosomal Storage Diseases	13.3%
65	Bone Demineralization, Pathologic	13.3%
66	Cytochrome-c Oxidase Deficiency	13.3%
67	Peroxisomal Disorders	13.3%
68	Post-Traumatic Osteoporosis	13.3%
69	Celiac Disease	13.2%
70	Sprue, Tropical	13.2%
71	Steatorrhea	13.2%
72	Sprue	13.2%
73	Osteomalacia	13%
74	Hyperlipoproteinemia Type III	12.7%
75	Smith-Lemli-Opitz Syndrome	12.6%
76	Galactosemias	12.5%
77	Urea Cycle Disorders, Inborn	12.5%
78	Tyrosinemias	12.5%
79	Hypercholesterolemia	12.2%
80	Hyperlipoproteinemias	12.2%
81	Hypertriglyceridemia	12.2%
82	Congenital Hyperinsulinism	12.2%
83	Hypoalphalipoproteinemias	12%
84	Familial Hypophosphatemic Rickets	11.5%
85	Mitochondrial Encephalomyopathies	11.5%
86	Gaucher Disease	10.9%
87	Hyperphosphaturia	10.9%
88	Glycogen storage disease type II	10.6%
89	Homocystinuria	10.4%
90	Child Nutrition Disorders	10.3%
91	Hypervitaminosis A	10.3%
92	Infant Nutrition Disorders	10.3%
93	Malnutrition	10.3%
94	Mitochondrial Myopathies	10.2%
95	Myelinolysis, Central Pontine	10.1%
96	Glycosuria	9.9%
97	Reye Syndrome	9.9%
98	Acidosis, Respiratory	9.9%
99	Adiposis Dolorosa	9.9%
100	Alkalosis, Respiratory	9.9%
101	Hepatic Encephalopathy	9.8%
102	Tay-Sachs Disease	9.8%
103	Nesidioblastosis	9.8%
104	Alkaptonuria	9.8%
105	Glycogen Storage Disease	9.8%
106	Hypophosphatasia	9.8%
107	Insulin Resistance	9.8%
108	Osteoporosis, Postmenopausal	9.8%
109	Propionic acidemia	9.8%
110	Dihydropyrimidine Dehydrogenase Deficiency	9.8%
111	Cystinosis	9.8%
112	Amyloid Neuropathies, Familial	9.8%
113	Renal tubular acidosis	9.7%
114	Niemann-Pick Disease, Type C	9.3%
115	Neuronal Ceroid-Lipofuscinoses	9%
116	HIV Wasting Syndrome	8.8%
117	Fabry Disease	8.5%
118	HIV-Associated Lipodystrophy Syndrome	8.4%
119	MELAS Syndrome	8.2%
120	Renal Osteodystrophy	8.2%
121	Renal rickets	8.2%
122	Porphyrias, Hepatic	8.1%
123	Glycogen Storage Disease Type I	8.1%
124	Glycogen Storage Disease Type V	8.1%
125	Zellweger Syndrome	8%
126	Mucopolysaccharidosis III	8%
127	Adrenoleukodystrophy	8%
128	Necrobiosis Lipoidica Diabeticorum	7.9%
129	Menkes Kinky Hair Syndrome	7.9%
130	Fanconi Anemia	7.8%
131	Wernicke Encephalopathy	7.7%
132	Gestational Diabetes	7.7%
133	Latent Autoimmune Diabetes in Adults	7.7%
134	Diabetes Mellitus, Experimental	7.6%
135	Hepatolenticular Degeneration	7.4%
136	Nephrocalcinosis	7.4%
137	Tetany	7.4%
138	Refsum Disease	7.3%
139	Glycosuria, Renal	7.3%
140	Cerebral Amyloid Angiopathy	7.2%
141	Deficiency Diseases	6.7%
142	Starvation	6.7%
143	Refeeding Syndrome	6.7%
144	Friedreich Ataxia	6.5%
145	Familial Periodic Paralysis	6%
146	Primary amyloidosis	6%
147	Variegate Porphyria	5.9%
148	Acute intermittent porphyria	5.9%
149	Porphyria Cutanea Tarda	5.9%
150	Renal Aminoacidurias	5.8%
151	Fanconi Syndrome	5.8%
152	Pseudohypoaldosteronism	5.8%
153	Liddle Syndrome	5.8%
154	Kernicterus	5.7%
155	Kearns-Sayre syndrome	5.7%
156	Cockayne Syndrome	5.7%
157	Canavan Disease	5.4%
158	Alexander Disease	5.4%
159	Sjogren-Larsson Syndrome	5.4%
160	Mucopolysaccharidosis II	5.3%
161	Ataxia Telangiectasia	5.1%
162	Gout	5%
163	Amyotrophic Lateral Sclerosis	5%
164	Kwashiorkor	4.9%
165	Magnesium Deficiency	4.9%
166	Potassium Deficiency	4.9%
167	Protein Deficiency	4.9%
168	Avitaminosis	4.9%
169	Optic Atrophy, Hereditary, Leber	4.9%
170	Antley-Bixler Syndrome Phenotype	4.9%
171	Hypokalemic periodic paralysis	4.9%
172	Frontotemporal dementia	4.8%
173	Cystinuria	4.8%
174	Xeroderma Pigmentosum	4.5%
175	CREST Syndrome	4.2%
176	Ascorbic Acid Deficiency	4.1%
177	Vitamin A Deficiency	4.1%
178	Vitamin D Deficiency	4.1%
179	Vitamin E Deficiency	4.1%
180	Marasmus	4.1%
181	Arthritis, Gouty	4.1%
182	Albinism	3.7%
183	Folic Acid Deficiency	3.6%
184	Pellagra	3.6%
185	Thiamine Deficiency	3.6%
186	Vitamin B 12 Deficiency	3.6%
187	Vitamin B 6 Deficiency	3.6%
188	Pyridoxine Deficiency	3.6%
189	Beriberi	3.4%
190	Ichthyosis, X-Linked	3%
191	Obesity	2.6%
192	Obesity, Abdominal	2.4%
193	Anemia, Pernicious	2.3%
194	Vitamin K Deficiency	2.1%
195	Pediatric Obesity	1.9%
196	Scurvy	1.8%
197	Prader-Willi Syndrome	1.6%
198	Subacute Combined Degeneration	1.2%

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