MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hypoprothrombinemias

(UMLS:C4722227)

Definition:: Absence or reduced levels of PROTHROMBIN in the blood.
UMLS ID:: C4722227
MeSH ID:: D007020

Classification 1:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.100.100.550|C15.378.100.141.550|C15.378.463.550

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.099.550

Synonym(s)

Hypoprothrombinemias

Factor II Deficiency

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aspirin	6054600	CTD
2	Clindamycin	6295339	CTD
3	Gentamicins	6295339	CTD
4	Moxalactam	1561959	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Afibrinogenemia	73.8%
2	Factor VII Deficiency	73.8%
3	Factor X Deficiency	73.8%
4	Factor XII Deficiency	73.8%
5	Hemophilia A	73.8%
6	Factor VIII Deficiency	73.8%
7	Factor V deficiency	73.8%
8	Factor XI Deficiency	73.8%
9	Activated Protein C Resistance	67.2%
10	Thrombasthenia	64.6%
11	Disseminated Intravascular Coagulation	61.3%
12	Antithrombin III Deficiency	58%
13	Protein C Deficiency	58%
14	Thrombocythemia, Essential	56.2%
15	Protein S Deficiency	53.8%
16	Wiskott-Aldrich Syndrome	51.1%
17	Vitamin K Deficiency	46.8%
18	Anemia	32%
19	Blood Platelet Disorders	32%
20	Bone Marrow Diseases	32%
21	Leukocyte Disorders	32%
22	Methemoglobinemia	32%
23	Pancytopenia	32%
24	Polycythemia	32%
25	Sulfhemoglobinemia	32%
26	Thrombophilia	32%
27	Erythrocytosis	32%
28	Anemia, Sickle Cell	29%
29	Thalassemia	29%
30	Bone Marrow Neoplasms	28.3%
31	Thrombocytosis	27.9%
32	Transfusion Reaction	27.6%
33	Hypotensive Transfusion Reaction	27.6%
34	Pregnancy Complications, Hematologic	27%
35	Hematologic Neoplasms	27%
36	Anemia, Diamond-Blackfan	26.8%
37	Pelger-Huet Anomaly	26.7%
38	Autoimmune thrombocytopenia	26.6%
39	Immune thrombocytopenic purpura	26.6%
40	Factor II deficiency	26.2%
41	Hypoprothrombinemias	26.2%
42	Purpura, Thrombotic Thrombocytopenic	26.1%
43	Polycythemia Vera	25.6%
44	Ecchymosis	25.5%
45	Petechiae	25.5%
46	Purpura	25.5%
47	Purpura, Hyperglobulinemic	25.4%
48	Hemoglobinuria, Paroxysmal	22.8%
49	Leukemoid Reaction	22.8%
50	Cryoglobulinemia	22.1%
51	Sickle Cell Trait	21.6%
52	Waldenstrom Macroglobulinemia	21.1%
53	Waterhouse-Friderichsen Syndrome	20.7%
54	Anemia, Neonatal	20%
55	Hemorrhagic Disorders	20%
56	Thrombocytopenic purpura	19.8%
57	Anemia, Hemolytic	19.7%
58	Anemia, Macrocytic	19.7%
59	Eosinophilia	19.7%
60	Hypoproteinemia	19.7%
61	Leukopenia	19.7%
62	Thrombocytopenia	19.7%
63	Leukostasis	19.7%
64	MYELODYSPLASTIC SYNDROME	19.7%
65	Lymphatic Diseases	19.2%
66	Agammaglobulinemia	19%
67	Fanconi Anemia	18.4%
68	Multiple Myeloma	17.8%
69	Acute Chest Syndrome	17.6%
70	Hydrops Fetalis	17.4%
71	Monoclonal Gammopathy of Undetermined Significance	17.2%
72	Purpura Fulminans	17.2%
73	Leukocytosis	16.7%
74	Paraproteinemias	16.7%
75	Pleocytosis	16.7%
76	Infectious Mononucleosis	16.5%
77	Chronic granulomatous disease	15.5%
78	Shwartzman Phenomenon	15.5%
79	Hemangioma, Cavernous	15.4%
80	Scurvy	15.4%
81	Hemolytic-Uremic Syndrome	15.2%
82	Pseudoxanthoma Elasticum	14.8%
83	Heavy Chain Disease	14.6%
84	Hypergammaglobulinemia	14.4%
85	Transfusion-Related Acute Lung Injury	14.2%
86	Primary Myelofibrosis	13.7%
87	Agranulocytosis	13.7%
88	Anemia, Megaloblastic	13.7%
89	Lymphocytosis	13.7%
90	Myelofibrosis	13.7%
91	Myeloid Metaplasia	13.7%
92	Hypoalbuminemia	13.7%
93	Hypereosinophilic syndrome	13.7%
94	bone marrow fibrosis	13.7%
95	Thrombotic Microangiopathies	13.7%
96	Atypical Hemolytic Uremic Syndrome	12.4%
97	Lymphatic Abnormalities	12.4%
98	Blood Coagulation Disorders	12%
99	Autoimmune Lymphoproliferative Syndrome	11.8%
100	Lymphopenia	11.6%
101	Job Syndrome	11.5%
102	Leukemia, Myelomonocytic, Chronic	11.4%
103	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	11.4%
104	Lymphangiectasis, Intestinal	11.3%
105	Kernicterus	11.3%
106	Aicardi's syndrome	11%
107	Fragile X Syndrome	10.8%
108	Neutropenia	10.7%
109	Adenitis	10.7%
110	Histiocytosis	10.7%
111	Lymphadenitis	10.7%
112	Lymphangitis	10.7%
113	Lymphedema	10.7%
114	Splenic Diseases	10.7%
115	Thymus Hyperplasia	10.7%
116	Pseudolymphoma	10.7%
117	Lymphadenopathy	10.7%
118	CHARGE Syndrome	10.5%
119	Neoplastic Syndromes, Hereditary	10.3%
120	Cystic Fibrosis	10.3%
121	Eosinophilic Granuloma	10.3%
122	POEMS Syndrome	10.2%
123	Ichthyosis, X-Linked	10.1%
124	Multiple Epiphyseal Dysplasia	10%
125	Osteochondrodysplasias	10%
126	Werner Syndrome	10%
127	Myasthenic Syndromes, Congenital	10%
128	Eosinophilia-Myalgia Syndrome	10%
129	Albinism	9.9%
130	Muscular Dystrophy, Duchenne	9.8%
131	Beckwith-Wiedemann Syndrome	9.4%
132	Wolf-Hirschhorn Syndrome	9.4%
133	Febrile Neutropenia	9.3%
134	Nail-Patella Syndrome	9.2%
135	Cockayne Syndrome	9.2%
136	Pulmonary Eosinophilia	9.1%
137	Eosinophilic Pneumonia	9.1%
138	Alstrom Syndrome	9%
139	Lymphocele	9%
140	Lymphoproliferative Disorders	9%
141	Leukemia, Myeloid, Chronic-Phase	8.9%
142	Anemia, Pernicious	8.9%
143	Thymus Neoplasms	8.9%
144	Mucopolysaccharidosis II	8.9%
145	Dwarfism	8.8%
146	Muscular Dystrophy	8.5%
147	Osteogenesis Imperfecta	8.5%
148	Rett Syndrome	8.4%
149	Menkes Kinky Hair Syndrome	8.3%
150	Smith-Magenis syndrome	8.3%
151	Cri-du-Chat Syndrome	8.2%
152	Down Syndrome	8.2%
153	Trisomy 21	8.2%
154	Kartagener Syndrome	8.1%
155	Familial Mediterranean Fever	7.9%
156	Holoprosencephaly	7.8%
157	Mucocutaneous Lymph Node Syndrome	7.6%
158	Marfan Syndrome	7.6%
159	Angioedemas, Hereditary	7.4%
160	Ectodermal Dysplasia	7.4%
161	Aplasia Cutis Congenita	7.4%
162	Prader-Willi Syndrome	7.3%
163	Smith-Lemli-Opitz Syndrome	7.2%
164	Myotonic Dystrophy	7.2%
165	Neuronal Ceroid-Lipofuscinoses	7.1%
166	Adrenoleukodystrophy	7%
167	Rubinstein-Taybi Syndrome	6.9%
168	Tuberous Sclerosis	6.9%
169	Deformity	6.8%
170	Kallmann Syndrome	6.7%
171	Sjogren-Larsson Syndrome	6.6%
172	Amino Acid Metabolism, Inborn Errors	6.6%
173	Carbohydrate Metabolism, Inborn Errors	6.6%
174	Metal Metabolism, Inborn Errors	6.6%
175	Progeria	6.6%
176	Lysosomal Storage Diseases	6.6%
177	Cytochrome-c Oxidase Deficiency	6.6%
178	Peroxisomal Disorders	6.6%
179	Elephantiasis	6.6%
180	Hypersplenism	6.6%
181	Sarcoidosis	6.6%
182	Elephantiasis Nostras Verrucosa	6.6%
183	Hepatolenticular Degeneration	6.6%
184	Polycystic Kidney Diseases	6.5%
185	Williams Syndrome	6.5%
186	Primary Ciliary Dyskinesia	6.5%
187	Refsum Disease	6.5%
188	Fabry Disease	6.4%
189	Amyloid Neuropathies, Familial	6.2%
190	Retinal Dysplasia	6%
191	Glycogen storage disease type II	6%
192	Aniridia	6%
193	Epidermolysis Bullosa	5.9%
194	Galactosemias	5.8%
195	Urea Cycle Disorders, Inborn	5.8%
196	Tyrosinemias	5.8%
197	Fetal Diseases	5.7%
198	Cutis Laxa	5.7%
199	Retinitis Pigmentosa	5.7%
200	Pigmentary retinopathy	5.7%
201	Porokeratosis	5.7%
202	Keratoderma, Palmoplantar	5.7%
203	Welander Distal Myopathy	5.6%
204	Niemann-Pick Disease, Type C	5.6%
205	Granuloma	5.6%
206	Histiocytic Disorders, Malignant	5.6%
207	Splenic Infarction	5.6%
208	Splenic Neoplasms	5.6%
209	Histiocytosis, Langerhans-Cell	5.5%
210	Tumor Lysis Syndrome	5.5%
211	Ataxia Telangiectasia	5.5%
212	Mucopolysaccharidosis III	5.4%
213	Optic Atrophy, Hereditary, Leber	5.3%
214	Hyperphosphaturia	5.3%
215	Canavan Disease	5.3%
216	Alexander Disease	5.3%
217	Sezary Syndrome	5.2%
218	Zellweger Syndrome	5.1%
219	Duane Retraction Syndrome	5%
220	Porphyrias, Hepatic	5%
221	Gaucher Disease	5%
222	Peutz-Jeghers Syndrome	4.9%
223	Myotonia Congenita	4.9%
224	Brain Diseases, Metabolic, Inborn	4.9%
225	Classical Lissencephalies and Subcortical Band Heterotopias	4.9%
226	Dystonia Musculorum Deformans	4.9%
227	Alkaptonuria	4.9%
228	Glycogen Storage Disease	4.9%
229	Hypophosphatasia	4.9%
230	Propionic acidemia	4.9%
231	Dihydropyrimidine Dehydrogenase Deficiency	4.9%
232	Cystinosis	4.9%
233	Homocystinuria	4.9%
234	Lafora Disease	4.9%
235	Unverricht-Lundborg Syndrome	4.9%
236	Leigh Disease	4.9%
237	Polycystic Kidney, Autosomal Dominant	4.9%
238	Splenic Rupture	4.8%
239	Lymphoma	4.8%
240	Thymoma	4.7%
241	Hyperkeratosis, Epidermolytic	4.7%
242	Lymphohistiocytosis, Hemophagocytic	4.6%
243	Erdheim-Chester Disease	4.6%
244	Tay-Sachs Disease	4.5%
245	Meconium Aspiration Syndrome	4.5%
246	Multiple Endocrine Neoplasia	4.5%
247	Xeroderma Pigmentosum	4.4%
248	Congenital Hypothyroidism	4.4%
249	Dermatitis, Atopic	4.4%
250	Carbamoyl-Phosphate Synthase I Deficiency Disease	4.4%
251	Charcot-Marie-Tooth Disease	4.3%
252	Antley-Bixler Syndrome Phenotype	4.3%
253	Hypolipoproteinemias	4.2%
254	Papillon-Lefevre Disease	4.2%
255	Hyperlipidemia, Familial Combined	4.2%
256	Hyperlipoproteinemia Type III	4.2%
257	Xeroderma	4.2%
258	Mobius Syndrome	4.2%
259	Glycogen Storage Disease Type I	4.1%
260	Glycogen Storage Disease Type V	4.1%
261	Basal Cell Nevus Syndrome	4%
262	Abdominal Cramps	4%
263	Abnormalities, Drug-Induced	4%
264	Amniotic Band Syndrome	4%
265	Asphyxia Neonatorum	4%
266	Infant, Premature, Diseases	4%
267	Situs Inversus	4%
268	Infantile Colic	4%
269	Behcet Syndrome	4%
270	Malignant histiocytosis	3.8%
271	Sarcoidosis, Pulmonary	3.8%
272	Histiocytic sarcoma	3.8%
273	Familial Periodic Paralysis	3.7%
274	Klinefelter Syndrome	3.7%
275	Lactose Intolerance	3.7%
276	Variegate Porphyria	3.7%
277	Acute intermittent porphyria	3.7%
278	Porphyria Cutanea Tarda	3.7%
279	Hyperhomocysteinemia	3.7%
280	Renal Aminoacidurias	3.7%
281	Fanconi Syndrome	3.7%
282	Pseudohypoaldosteronism	3.7%
283	Liddle Syndrome	3.7%
284	Hyperlipoproteinemia Type IV	3.6%
285	Hyperlipoproteinemia Type V	3.6%
286	Huntington Disease	3.6%
287	Hypoalphalipoproteinemias	3.5%
288	Eye Abnormalities	3.4%
289	Cardiovascular Abnormalities	3.4%
290	Turner Syndrome	3.4%
291	Skin Abnormalities	3.4%
292	Congenital Microtia	3.4%
293	Persistent Fetal Circulation Syndrome	3.3%
294	Congenital diaphragmatic hernia	3.3%
295	Gout	3.3%
296	Umbilical hernia	3.3%
297	Anencephaly	3.3%
298	Splenosis	3.3%
299	Multiple Endocrine Neoplasia Type 1	3.3%
300	Pseudohypoparathyroidism	3.3%
301	Nephroblastoma	3.3%
302	Hodgkin Disease	3.3%
303	Lymphoma, Non-Hodgkin	3.3%
304	Leukemia, T-Cell	3.3%
305	Leukemia, B-Cell	3.3%
306	Friedreich Ataxia	3.3%
307	Renal tubular acidosis	3.2%
308	Hypokalemic periodic paralysis	3%
309	Cystinuria	3%
310	Adenomatous Polyposis Coli	3%
311	Familial Hypophosphatemic Rickets	3%
312	Urogenital Abnormalities	3%
313	Neonatal Abstinence Syndrome	2.9%
314	Maxillofacial Abnormalities	2.9%
315	Dural Arteriovenous Fistula	2.9%
316	Dextrocardia	2.9%
317	Composite Lymphoma	2.9%
318	Fetal Growth Retardation	2.9%
319	Lymphangioleiomyomatosis	2.8%
320	Fetal Hypoxia	2.8%
321	Congenital nystagmus	2.8%
322	Fetal Alcohol Spectrum Disorders	2.8%
323	Toxoplasmosis, Congenital	2.8%
324	Syphilis, Congenital	2.8%
325	Arthritis, Gouty	2.7%
326	Glycosuria, Renal	2.6%
327	Prune Belly Syndrome	2.6%
328	Twins, Conjoined	2.6%
329	Waardenburg Syndrome	2.6%
330	Lymphoma, Follicular	2.5%
331	T-Cell Lymphoma	2.5%
332	Mantle cell lymphoma	2.5%
333	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
334	Leukemia, Large Granular Lymphocytic	2.5%
335	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
336	Congenital Hyperinsulinism	2.5%
337	Chorioamnionitis	2.5%
338	Scimitar Syndrome	2.4%
339	Denys-Drash Syndrome	2.3%
340	Acrocephalosyndactylia	2.3%
341	Microcephaly	2.2%
342	Macrocephaly	2.2%
343	MELAS Syndrome	2.2%
344	Anophthalmos	2.2%
345	Anus, Imperforate	2.2%
346	Hydranencephaly	2.2%
347	Microphthalmos	2.2%
348	Neural Tube Defects	2.2%
349	Paralysis, Obstetric	2.2%
350	Retinopathy of Prematurity	2.2%
351	Tethered Cord Syndrome	2.2%
352	Iniencephaly	2.2%
353	Craniorachischisis	2.2%
354	Limb Deformities, Congenital	2.2%
355	Exencephaly	2.2%
356	Septo-Optic Dysplasia	2.2%
357	Craniofacial Abnormalities	2.2%
358	Cortical Dysplasia	2.2%
359	Malformations of Cortical Development	2.2%
360	Anorectal Malformations	2.2%
361	Abnormalities, Radiation-Induced	2.2%
362	Bloom Syndrome	2.2%
363	Lymphoma, T-Cell, Cutaneous	2.2%
364	Lymphoma, AIDS-Related	2.2%
365	Enteropathy-Associated T-Cell Lymphoma	2.2%
366	Primary Effusion Lymphoma	2.2%
367	Bronchopulmonary Dysplasia	2.2%
368	Craniosynostosis	2.2%
369	Syndactyly	2.2%
370	Brachycephaly	2.2%
371	Porencephaly	2%
372	Mycosis Fungoides	2%
373	Lymphomatoid Papulosis	2%
374	Plasmablastic lymphoma	2%
375	Noonan Syndrome	2%
376	Ophthalmia Neonatorum	2%
377	Cleft Palate	1.9%
378	Lymphomatoid Granulomatosis	1.9%
379	Blepharophimosis	1.9%
380	Laryngostenosis	1.9%
381	Mouth Abnormalities	1.9%
382	Respiratory Distress Syndrome, Newborn	1.9%
383	Esophageal Atresia	1.9%
384	Intestinal Atresia	1.9%
385	Horseshoe Kidney	1.9%
386	Pectus excavatum	1.9%
387	Klippel-Feil Syndrome	1.9%
388	Gastroschisis	1.9%
389	Synostosis	1.9%
390	Acrodermatitis	1.9%
391	Gianotti-Crosti Syndrome	1.9%
392	Jaw Abnormalities	1.8%
393	Poland Syndrome	1.8%
394	Burkitt Lymphoma	1.7%
395	Arthrogryposis	1.7%
396	Choanal Atresia	1.7%
397	Tracheobronchomegaly	1.7%
398	Laryngocele	1.7%
399	Choledochal Cyst	1.7%
400	Hermaphroditism	1.7%
401	Disorders of Sex Development	1.7%
402	Cryptorchidism	1.7%
403	Hypospadias	1.7%
404	Central Nervous System Cysts	1.7%
405	Dandy-Walker Syndrome	1.7%
406	Amelia	1.6%
407	Arachnodactyly	1.6%
408	Ectopia Cordis	1.6%
409	Ectromelia	1.6%
410	Hemimelia	1.6%
411	Leukomalacia, Periventricular	1.6%
412	Meningomyelocele	1.6%
413	Phocomelia	1.6%
414	Sirenomelia	1.6%
415	Spina Bifida	1.6%
416	Polydactyly	1.6%
417	Brachydactyly	1.6%
418	Plagiocephaly	1.6%
419	Lower Extremity Deformities, Congenital	1.6%
420	Upper Extremity Deformities, Congenital	1.6%
421	Single umbilical artery	1.6%
422	Nesidioblastosis	1.6%
423	Micrognathism	1.5%
424	Pierre Robin Syndrome	1.5%
425	Laryngomalacia	1.5%
426	Pectus carinatum	1.5%
427	Bladder Exstrophy	1.5%
428	Epispadias	1.5%
429	Multicystic Dysplastic Kidney	1.5%
430	Aortic coarctation	1.4%
431	Cor Triatriatum	1.4%
432	Coronary Vessel Anomalies	1.4%
433	Dental Enamel Hypoplasia	1.4%
434	Patent ductus arteriosus	1.4%
435	Ebstein Anomaly	1.4%
436	Heart Septal Defects	1.4%
437	Hyaline Membrane Disease	1.4%
438	Hypodontia	1.4%
439	Macrostomia	1.4%
440	Meningocele	1.4%
441	Microstomia	1.4%
442	Tetralogy of Fallot	1.4%
443	Transposition of Great Vessels	1.4%
444	Hypoplastic Left Heart Syndrome	1.4%
445	May-Thurner Syndrome	1.4%
446	Encephalocele	1.4%
447	Retrognathia	1.4%
448	Craniofacial Dysostosis	1.4%
449	Wolff-Parkinson-White Syndrome	1.4%
450	Dermal Sinus	1.4%
451	Spina Bifida Cystica	1.4%
452	Spina Bifida Occulta	1.4%
453	Lissencephaly	1.4%
454	Polymicrogyria	1.4%
455	Pachygyria	1.4%
456	Schizencephaly	1.4%
457	Periventricular Nodular Heterotopia	1.4%
458	Hyperandrogenism	1.3%
459	Prognathism	1.3%
460	Long QT Syndrome	1.2%
461	Platybasia	1.2%
462	Tricuspid Atresia	1.2%
463	Arrhythmogenic Right Ventricular Dysplasia	1.2%
464	Gonadal Dysgenesis	1.2%
465	Bronchomalacia	1.2%
466	Adrenogenital Syndrome	1.2%
467	Tracheomalacia	1.2%
468	Ovotesticular Disorders of Sex Development	1.2%
469	Aortopulmonary Septal Defect	1.2%
470	Double Outlet Right Ventricle	1.2%
471	Endocardial Cushion Defects	1.2%
472	Myocardial bridging	1.2%
473	Aorticopulmonary Septal Defect	1.2%
474	Truncus Arteriosus, Persistent	1%
475	Goldenhar Syndrome	1%
476	Mandibulofacial Dysostosis	1%
477	Romano-Ward Syndrome	1%
478	Talipes	0.9%
479	Congenital clubfoot	0.9%
480	Vertical Talus	0.9%
481	Arteriovenous fistula	0.8%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234