MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pick Disease of the Brain

(UMLS:C0236642)

Definition:: A rare form of DEMENTIA that is sometimes familial. Clinical features include APHASIA; APRAXIA; CONFUSION; ANOMIA; memory loss; and personality deterioration. This pattern is consistent with the pathologic findings of circumscribed atrophy of the poles of the FRONTAL LOBE and TEMPORAL LOBE. Neuronal loss is maximal in the HIPPOCAMPUS, entorhinal cortex, and AMYGDALA. Some ballooned cortical neurons contain argentophylic (Pick) bodies. (From Brain Pathol 1998 Apr;8(2):339-54; Adams et al., Principles of Neurology, 6th ed, pp1057-9)
UMLS ID:: C0236642
MeSH ID:: D020774

Classification 1:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.140.380.266.299.500

Classification 2:

Name:

Mental Disorders
MeSH Tree Number(s):: F03.615.400.380.299.500

Synonym(s)

Pick Disease of the Brain

Circumscribed cerebral atrophy

Lobar cerebral atrophy

PICK DISEASE OF BRAIN

Pick Disease

Pick's Disease

Pick's disease

Pick; disease or syndrome

Picks Disease

10.

brain; disease, Pick

11.

dementia frontotemporal

12.

disease (or disorder); brain, Pick

13.

disease picks

14.

frontotemporal dementia

15.

pick disease

16.

pick s disease

17.

pick's disease

18.

picks disease

19.

syndrome; Pick

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fluoxetine		8041377	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Kluver-Bucy Syndrome	29.2%
2	Creutzfeldt-Jakob disease	25.8%
3	Presenile dementia	25%
4	Senile dementia	25%
5	Lewy Body Disease	23.1%
6	Huntington Disease	20.6%
7	Dementia, Vascular	20.4%
8	Akinetic Mutism	16.9%
9	Anoxic Encephalopathy	16.9%
10	Basal Ganglia Diseases	16.9%
11	Brain Damage, Chronic	16.9%
12	Cerebellar Diseases	16.9%
13	Encephalitis	16.9%
14	Encephalomalacia	16.9%
15	Epilepsy	16.9%
16	Hydrocephalus	16.9%
17	Congenital Hydrocephalus	16.9%
18	Hypothalamic Diseases	16.9%
19	Thalamic Diseases	16.9%
20	Intracranial Hypertension	16.9%
21	Aura	16.9%
22	Leukoencephalopathy	16.9%
23	Neuroaxonal Dystrophies	16.9%
24	Headache Disorders	16.9%
25	Intracranial Hypotension	16.9%
26	Brain Edema	16.9%
27	Brain Hypoxia	16.9%
28	Aqueductal Stenosis	16.9%
29	AIDS Dementia Complex	16.7%
30	Encephalomyelitis	16.1%
31	Subdural Effusion	15.7%
32	Cognition Disorders	14.8%
33	Meningoencephalitis	14%
34	Meningitis	14%
35	Movement Disorders	14%
36	Pachymeningitis	14%
37	Spinal Cord Diseases	14%
38	Brain Diseases, Metabolic	13%
39	Cerebrovascular Disorders	13%
40	Cerebrovascular Insufficiency	13%
41	Parkinsonian Disorders	12.5%
42	Pneumocephalus	12.3%
43	Brain Abscess	12.3%
44	Multiple System Atrophy	12.1%
45	Dandy-Walker Syndrome	11.9%
46	Ocular Motility Disorders	11.9%
47	Cyclophoria	11.9%
48	Sleep Wake Disorders	11.9%
49	Brain Injuries	11.7%
50	Brain Neoplasms	11.7%
51	Neurotic Disorders	11.3%
52	Basal Ganglia Cerebrovascular Disease	11.3%
53	Posterior Leukoencephalopathy Syndrome	11.1%
54	Posterior reversible encephalopathy syndrome	11.1%
55	Central Nervous System Infection	11.1%
56	Amnesia, Transient Global	11%
57	Myelitis	11%
58	Marchiafava-Bignami Disease	10.6%
59	Brain Death	10.5%
60	Epilepsy, Post-Traumatic	10%
61	Meige Syndrome	10%
62	Cerebral Ventriculitis	10%
63	Anxiety Disorders	9.7%
64	Avoidant Personality Disorder	9.7%
65	Dissociative disorder	9.7%
66	Frigidity	9.7%
67	Hypoactive Sexual Desire Disorder	9.7%
68	Disruptive, Impulse Control, and Conduct Disorders	9.7%
69	Intermittent Explosive Disorder	9.7%
70	Kleptomania	9.7%
71	Narcissistic Personality Disorder	9.7%
72	Personality Disorders	9.7%
73	Sexual Aversion Disorder	9.7%
74	Somatoform Disorder	9.7%
75	Dissociation	9.7%
76	Motor Disorders	9.7%
77	Mood Disorders	9.7%
78	Schizophrenia Spectrum and Other Psychotic Disorders	9.7%
79	Neurodevelopmental Disorders	9.7%
80	Feeding and Eating Disorders	9.7%
81	Cranial nerve diseases	9.5%
82	Demyelinating Diseases	9.5%
83	Demyelination	9.5%
84	Neuromuscular Diseases	9.5%
85	Chronobiology Disorders	9.5%
86	Leukomalacia, Periventricular	9.4%
87	Epidural Abscess	9.3%
88	Cerebral Palsy	9.3%
89	Epilepsies, Partial	9.3%
90	Epilepsy, Generalized	9.3%
91	Pseudotumor Cerebri	9.3%
92	Hypertensive Encephalopathy	9.3%
93	Simple Partial Seizures	9.3%
94	Epilepsy, Reflex	9.3%
95	Headache Disorders, Primary	9.3%
96	Headache Disorders, Secondary	9.3%
97	Medication overuse headache	9.3%
98	Amblyopia	9.3%
99	Prion Diseases	9.1%
100	Vascular Headaches	9%
101	Hypoxia-Ischemia, Brain	8.9%
102	Consciousness Disorders	8.7%
103	Depressed Level of Consciousness	8.7%
104	Parkinson Disease	8.6%
105	Neuroleptic Malignant Syndrome	8.5%
106	Myelinolysis, Central Pontine	8.5%
107	Stiff-Person Syndrome	8.5%
108	Myoclonic Epilepsy	8.3%
109	Epilepsy, Temporal Lobe	8.3%
110	Epilepsy, Rolandic	8.3%
111	Benign Rolandic Epilepsy	8.3%
112	Amnesia	8%
113	Delirium	8%
114	Dissociative Amnesia	8%
115	Global Amnesia	8%
116	Dystonia Musculorum Deformans	8%
117	Cerebellar Neoplasms	7.8%
118	Drug abuse	7.6%
119	Substance Dependence	7.6%
120	Substance-Related Disorders	7.6%
121	Drug Dependence	7.6%
122	Spinal Cord Injuries	7.6%
123	Separation Anxiety Disorder	7.5%
124	Restless Legs Syndrome	7.5%
125	Trauma, Nervous System	7.4%
126	Pituitary Diseases	7.4%
127	Spinal Muscular Atrophy	7.3%
128	Progressive Muscular Atrophy	7.3%
129	Parasomnia	7.3%
130	Dyssomnias	7.3%
131	Progressive supranuclear palsy	7.3%
132	Asterixis	7.3%
133	Ballismus	7.3%
134	Arachnoiditis	7.2%
135	Aseptic Meningitis	7.2%
136	Syringomyelia	7.2%
137	Essential Tremor	7.2%
138	Familial Tremor	7.2%
139	Pneumorrhachis	7.2%
140	Writer's Cramp	7.2%
141	Subacute Combined Degeneration	7.2%
142	Nervous System Neoplasms	7.2%
143	Neurologic Manifestations	7.2%
144	Neurotoxicity Syndromes	7.2%
145	Motor Neuron Disease	7.1%
146	Auditory Perceptual Disorders	7.1%
147	Carotid Artery Diseases	7%
148	Brain Ischemia	7%
149	Cerebrovascular accident	7%
150	Vasospasm, Intracranial	7%
151	Intracranial Arterial Diseases	7%
152	Limbic Encephalitis	6.8%
153	Meningitis, Bacterial	6.8%
154	Meningitis, Fungal	6.8%
155	Striatonigral Degeneration	6.7%
156	Brain Injuries, Diffuse	6.4%
157	Traumatic Brain Injury	6.4%
158	Cerebellar Ataxia	6.4%
159	Supratentorial Neoplasms	6.4%
160	Poliomyelitis	6.4%
161	Chronic Fatigue Syndrome	6.3%
162	Leukoencephalopathy, Progressive Multifocal	6.3%
163	Amyotrophic Lateral Sclerosis	6.3%
164	Vasculitis, Central Nervous System	6.1%
165	Persistent Vegetative State	6%
166	Paraneoplastic Cerebellar Degeneration	5.9%
167	Spinal Cord Neoplasms	5.8%
168	Hepatolenticular Degeneration	5.8%
169	Shy-Drager Syndrome	5.8%
170	Reye Syndrome	5.7%
171	Pituitary Apoplexy	5.7%
172	Intracranial Embolism and Thrombosis	5.6%
173	Hepatic Encephalopathy	5.6%
174	Lupus Vasculitis, Central Nervous System	5.6%
175	Brain Infarction	5.6%
176	Central Nervous System Fungal Infections	5.6%
177	Conus Medullaris Syndrome	5.6%
178	Spinal Cord Vascular Diseases	5.6%
179	Basal Ganglia Hemorrhage	5.6%
180	Post-Traumatic Headache	5.5%
181	Tension Headache	5.5%
182	Epilepsy, Complex Partial	5.5%
183	Migraine Disorders	5.5%
184	Abdominal Migraine	5.5%
185	Status Migrainosus	5.5%
186	Cervicogenic Headache	5.5%
187	Juvenile Myoclonic Epilepsy	5.5%
188	Myoclonic Epilepsies, Progressive	5.5%
189	MPTP Poisoning	5.4%
190	Polyradiculoneuropathy	5.4%
191	Polyradiculoneuritis	5.4%
192	Autonomic Dysreflexia	5.4%
193	Complex Regional Pain Syndromes	5.4%
194	Ophthalmoplegic Migraine	5.3%
195	Toxoplasmosis, Cerebral	5.3%
196	Encephalomyelitis, Acute Disseminated	5.2%
197	Brain Hemorrhage, Traumatic	5.2%
198	Akathisia, Drug-Induced	5.2%
199	Wernicke Encephalopathy	5.2%
200	Carotid Artery Injuries	5.1%
201	Sleep Disorders, Circadian Rhythm	5.1%
202	Leukoencephalitis, Acute Hemorrhagic	5.1%
203	Alexia, Pure	5%
204	Miller Fisher Syndrome	4.9%
205	Adjustment Disorders	4.9%
206	Affective Disorders, Psychotic	4.9%
207	Agoraphobia	4.9%
208	Anorexia Nervosa	4.9%
209	Antisocial Personality Disorder	4.9%
210	Bipolar Disorder	4.9%
211	Body Dysmorphic Disorders	4.9%
212	Borderline Personality Disorder	4.9%
213	Capgras Syndrome	4.9%
214	Child Behavior Disorders	4.9%
215	Developmental Disabilities	4.9%
216	Child Development Disorders, Pervasive	4.9%
217	Claustrophobia	4.9%
218	Conversion disorder	4.9%
219	Cyclothymic Disorder	4.9%
220	Dependent Personality Disorder	4.9%
221	Depressive disorder	4.9%
222	Developmental Coordination Disorder	4.9%
223	Exhibitionism	4.9%
224	Factitious Disorders	4.9%
225	Firesetting Behavior	4.9%
226	Head Banging	4.9%
227	Histrionic Personality Disorder	4.9%
228	Hypochondriasis	4.9%
229	Masochism	4.9%
230	Melancholia	4.9%
231	Motor Skills Disorders	4.9%
232	Dissociative Identity Disorder	4.9%
233	Neurasthenia	4.9%
234	Obsessive-Compulsive Disorder	4.9%
235	Oppositional Defiant Disorder	4.9%
236	Panic Disorder	4.9%
237	Paranoid Personality Disorder	4.9%
238	Pedophilia	4.9%
239	Pseudodementia	4.9%
240	Psychotic Disorders	4.9%
241	Sadism	4.9%
242	Schizoaffective Disorder	4.9%
243	Schizoid Personality Disorder	4.9%
244	Schizophrenia	4.9%
245	Schizophrenia, Childhood	4.9%
246	Schizotypal Personality Disorder	4.9%
247	Stereotypic Movement Disorder	4.9%
248	Transvestism	4.9%
249	Trichotillomania	4.9%
250	Voyeurism	4.9%
251	Attention Deficit and Disruptive Behavior Disorders	4.9%
252	Hyperkinetic Heart Syndrome	4.9%
253	Reactive Attachment Disorder	4.9%
254	Sexual and Gender Disorders	4.9%
255	Gender Dysphoria	4.9%
256	Paranoia	4.9%
257	Compulsive Personality Disorder	4.9%
258	Bulimia Nervosa	4.9%
259	Brain Diseases, Metabolic, Inborn	4.7%
260	Pituitary Adenoma	4.7%
261	Pituitary Neoplasms	4.7%
262	Friedreich Ataxia	4.7%
263	Dysautonomia	4.7%
264	Vagus Nerve Disorder	4.7%
265	Glossopharyngeal Neuralgia	4.7%
266	Abducens Nerve Diseases	4.7%
267	Heavy Metal Poisoning, Nervous System	4.7%
268	Neuromuscular Junction Diseases	4.7%
269	Tauopathies	4.7%
270	Trochlear Nerve Diseases	4.7%
271	Peripheral Nervous System Diseases	4.7%
272	Myelitis, Transverse	4.6%
273	Mitochondrial Encephalomyopathies	4.6%
274	Opsoclonus-Myoclonus Syndrome	4.6%
275	Central Nervous System Bacterial Infections	4.5%
276	Retrograde amnesia	4.4%
277	Amnesia, Anterograde	4.4%
278	Peripheral Nerve Injuries	4.4%
279	Myasthenia Gravis	4.3%
280	Empty Sella Syndrome	4.3%
281	Hyperpituitarism	4.3%
282	Hypopituitarism	4.3%
283	Hypophysitis	4.3%
284	Canavan Disease	4.3%
285	Alexander Disease	4.3%
286	Dyskinesia, Drug-Induced	4.2%
287	Cerebral Arterial Diseases	4.2%
288	Vertebrobasilar Insufficiency	4.2%
289	Basilar Artery Stenosis	4.2%
290	Vertebral Artery Stenosis	4.2%
291	Intracranial Hemorrhage, Hypertensive	4.2%
292	Transient Cerebral Ischemia	4.2%
293	Lafora Disease	4%
294	Unverricht-Lundborg Syndrome	4%
295	Moyamoya Disease	4%
296	Psychoses, Substance-Induced	3.9%
297	Scrapie	3.9%
298	Central Cord Syndrome	3.9%
299	Chorea	3.9%
300	Sleep Talking	3.9%
301	Sleep Disorders, Intrinsic	3.9%
302	Diffuse Axonal Injury	3.8%
303	Brain Stem Neoplasms	3.8%
304	Putaminal Hemorrhage	3.8%
305	Marijuana Abuse	3.8%
306	Opioid-Related Disorders	3.8%
307	Nicotine Dependence	3.8%
308	Opioid abuse	3.8%
309	Phencyclidine Abuse	3.8%
310	Substance Abuse, Intravenous	3.8%
311	Substance Withdrawal Syndrome	3.8%
312	Tobacco Use Disorder	3.8%
313	Alcohol-Related Disorders	3.8%
314	Amphetamine-Related Disorders	3.8%
315	Cocaine-Related Disorders	3.8%
316	Tuberculosis, Meningeal	3.7%
317	Mental Retardation	3.7%
318	Mental deficiency	3.7%
319	Intellectual Disability	3.7%
320	Gambling	3.7%
321	Premature Ejaculation	3.7%
322	Erectile dysfunction	3.7%
323	Cerebral Infarction	3.7%
324	Brain Stem Infarctions	3.7%
325	Myopathy	3.7%
326	Optic Neuropathy	3.7%
327	Cluster Headache	3.7%
328	Migraine with Aura	3.7%
329	Familial Hemiplegic Migraine	3.7%
330	Chronic Paroxysmal Hemicrania	3.7%
331	SUNCT Syndrome	3.7%
332	Paroxysmal Hemicrania	3.7%
333	Progressive bulbar palsy	3.7%
334	Bulbar palsy	3.7%
335	Kernicterus	3.6%
336	Lambert-Eaton Myasthenic Syndrome	3.6%
337	Botulism	3.6%
338	Central Nervous System Cysts	3.6%
339	Facial Nerve Diseases	3.6%
340	Craniocerebral Trauma	3.6%
341	Vestibulocochlear Nerve Diseases	3.5%
342	Decerebrate State	3.5%
343	Hemiparesis	3.5%
344	Hydranencephaly	3.5%
345	Meningism	3.5%
346	Neural Tube Defects	3.5%
347	Paresis	3.5%
348	Seizures	3.5%
349	Sensation Disorders	3.5%
350	Tethered Cord Syndrome	3.5%
351	Central Nervous System Neoplasms	3.5%
352	Complex partial seizures	3.5%
353	Iniencephaly	3.5%
354	Craniorachischisis	3.5%
355	Exencephaly	3.5%
356	Monoparesis	3.5%
357	Septo-Optic Dysplasia	3.5%
358	Cortical Dysplasia	3.5%
359	Neurogenic Inflammation	3.5%
360	Gait Disorders, Neurologic	3.5%
361	Neuromuscular Manifestations	3.5%
362	Malformations of Cortical Development	3.5%
363	Sweating, Gustatory	3.5%
364	Auriculotemporal Syndrome	3.5%
365	Guillain-Barre Syndrome	3.5%
366	Vertebral Artery Dissection	3.5%
367	Infarction, Middle Cerebral Artery	3.4%
368	Infarction, Anterior Cerebral Artery	3.4%
369	Infarction, Posterior Cerebral Artery	3.4%
370	Carotid Stenosis	3.4%
371	Intracranial Aneurysm	3.4%
372	Intracranial Arteriosclerosis	3.3%
373	Cerebral Atherosclerosis	3.3%
374	Subarachnoid Hemorrhage	3.3%
375	Cerebral Arteriosclerosis	3.3%
376	Cerebral Hemorrhage	3.3%
377	Cerebral Thrombosis	3.3%
378	Intracranial Embolism	3.3%
379	Intracranial Thrombosis	3.3%
380	Jet Lag Syndrome	3.3%
381	MELAS Syndrome	3.3%
382	Mutism	3.2%
383	Selective Mutism	3.2%
384	Meningitis, Cryptococcal	3.2%
385	Meningitis, Listeria	3.2%
386	Brain Contusion	3.2%
387	Torticollis	3.2%
388	Meningitis, Haemophilus	3.2%
389	Meningitis, Pneumococcal	3.2%
390	Olfactory Nerve Injuries	3.1%
391	Sleep Bruxism	3.1%
392	Causalgia	3.1%
393	Neonatal Abstinence Syndrome	3.1%
394	Ataxia Telangiectasia	3%
395	Adrenoleukodystrophy	3%
396	Spinal Cord Ischemia	3%
397	Horner Syndrome	3%
398	Tuberculosis, Central Nervous System	3%
399	Dyspareunia	3%
400	Alcohol Withdrawal Delirium	3%
401	Pupil Disorders	2.9%
402	Neurobehavioral Manifestations	2.9%
403	Subarachnoid Hemorrhage, Traumatic	2.9%
404	Carotid Artery, Internal, Dissection	2.9%
405	Multiple Sclerosis	2.9%
406	Brain Concussion	2.9%
407	Subacute Sclerosing Panencephalitis	2.9%
408	Paraneoplastic Encephalomyelitis	2.8%
409	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.8%
410	Reflex Sympathetic Dystrophy	2.8%
411	Nocturnal Myoclonus Syndrome	2.8%
412	Uveomeningoencephalitic Syndrome	2.8%
413	Hyperprolactinemia	2.8%
414	Sturge-Weber Syndrome	2.8%
415	Vertigo	2.8%
416	Alcohol-Induced Disorders, Nervous System	2.8%
417	Carotid Artery Thrombosis	2.8%
418	Subclavian Steal Syndrome	2.8%
419	Lateral Medullary Syndrome	2.8%
420	Giant Cell Arteritis	2.7%
421	Temporal Arteritis	2.7%
422	Combat Disorders	2.7%
423	Dysthymic Disorder	2.7%
424	Hysteria	2.7%
425	Schizophrenia, Catatonic	2.7%
426	Schizophrenia, Disorganized	2.7%
427	Post-Traumatic Stress Disorder	2.7%
428	Attention Deficit Disorder	2.7%
429	Seasonal Affective Disorder	2.7%
430	Conduct Disorder	2.7%
431	Social Communication Disorder	2.7%
432	Psychological Trauma	2.7%
433	Hoarding Disorder	2.7%
434	Phonological Disorder	2.7%
435	Neuromyelitis Optica	2.7%
436	Facial Nerve Injuries	2.7%
437	Sleep Deprivation	2.6%
438	Choroid Plexus Papilloma	2.5%
439	Enuresis	2.5%
440	Ophthalmoplegia	2.5%
441	External Ophthalmoplegia	2.5%
442	Neuroaspergillosis	2.4%
443	Neuritis	2.4%
444	Polyneuritis	2.4%
445	Radiculitis	2.4%
446	Polyneuropathy	2.4%
447	Mononeuritis	2.4%
448	Mononeuropathies	2.4%
449	Brachial Plexus Neuropathies	2.4%
450	Radiculopathy	2.4%
451	Mononeuropathy Multiplex	2.4%
452	Nerve Root Compression	2.4%
453	Alice in Wonderland Syndrome	2.4%
454	Voice Disorders	2.4%
455	Voice Disturbance	2.4%
456	Tuberous Sclerosis	2.4%
457	Refsum Disease	2.4%
458	Smith-Magenis syndrome	2.3%
459	Dural Arteriovenous Fistula	2.3%
460	Myasthenia Gravis, Autoimmune, Experimental	2.3%
461	Acromegaly	2.3%
462	Acrodynia	2.2%
463	Tardive Dyskinesia	2.2%
464	Cerebral Amyloid Angiopathy	2.2%
465	Sinus Thrombosis, Intracranial	2.2%
466	Disorders of Excessive Somnolence	2.2%
467	Sleep Initiation and Maintenance Disorders	2.2%
468	Night Terrors	2.2%
469	Somnambulism	2.2%
470	Transient Insomnia	2.2%
471	Sleep Paralysis	2.2%
472	Chronic Insomnia	2.2%
473	REM Sleep Behavior Disorder	2.2%
474	Hypersomnia	2.2%
475	Psychoses, Alcoholic	2.2%
476	Vocal Cord Paralysis	2.1%
477	Pseudorabies	2.1%
478	Galactosemias	2.1%
479	Urea Cycle Disorders, Inborn	2.1%
480	Tyrosinemias	2.1%
481	Dyscalculia	2.1%
482	Alcohol Use Disorder	2%
483	Alcoholic Intoxication	2%
484	Heroin Dependence	2%
485	Morphine Dependence	2%
486	Alcohol abuse	2%
487	Depression, Postpartum	2%
488	Premenstrual Dysphoric Disorder	2%
489	Neurosyphilis	2%
490	Brachial Plexus Neuritis	2%
491	Neuralgic Amyotrophy	2%
492	Reflex, Abnormal	2%
493	Hyporeflexia	2%
494	Hyperreflexia	2%
495	Charcot-Marie-Tooth Disease	2%
496	Myotonia Congenita	1.9%
497	Hematoma, Subdural	1.9%
498	Hematoma, Epidural, Cranial	1.9%
499	Homocystinuria	1.9%
500	Cerebrospinal Fluid Otorrhea	1.9%
501	Cerebrospinal Fluid Rhinorrhea	1.9%
502	Neuritis, Autoimmune, Experimental	1.9%
503	Gait Ataxia	1.9%
504	Leigh Disease	1.9%
505	Myositis	1.9%
506	Optic Atrophy	1.9%
507	Optic Neuritis	1.9%
508	Papilledema	1.9%
509	Strabismus	1.9%
510	Tolosa-Hunt Syndrome	1.9%
511	Isaacs syndrome	1.9%
512	Arsenic Poisoning	1.9%
513	Myotonic Disorders	1.9%
514	Myasthenic Syndromes, Congenital	1.9%
515	Diabetic Neuropathies	1.8%
516	Facial Injuries	1.8%
517	Facial Neuralgia	1.8%
518	Diabetic Amyotrophy	1.8%
519	Diabetic Autonomic Neuropathy	1.8%
520	Manganese Poisoning	1.8%
521	Orthostatic intolerance	1.8%
522	Alcohol Withdrawal Seizures	1.8%
523	Alexia	1.8%
524	Dyslexia	1.8%
525	Anosmia	1.8%
526	Ataxia	1.8%
527	Athetosis	1.8%
528	Catalepsy	1.8%
529	Dystonia	1.8%
530	Hemiplegia	1.8%
531	Locked-In Syndrome	1.8%
532	Meningeal Neoplasms	1.8%
533	Meningomyelocele	1.8%
534	Muscle Hypertonia	1.8%
535	Muscle hypotonia	1.8%
536	Myoclonus	1.8%
537	Myotonia	1.8%
538	Neuralgia	1.8%
539	Paraplegia	1.8%
540	Pseudobulbar Palsy	1.8%
541	Quadriplegia	1.8%
542	Spasm	1.8%
543	Spastic Paraplegia	1.8%
544	Status Epilepticus	1.8%
545	Taste Disorders	1.8%
546	Tremor	1.8%
547	West Nile Fever	1.8%
548	Spina Bifida	1.8%
549	Monoplegia	1.8%
550	Hypokinesia	1.8%
551	Paraparesis	1.8%
552	Bradykinesia	1.8%
553	Waxy flexibility	1.8%
554	Action Tremor	1.8%
555	Resting Tremor	1.8%
556	Dysosmia	1.8%
557	Quadriparesis	1.8%
558	Mercury Poisoning, Nervous System	1.8%
559	Olfaction Disorders	1.8%
560	Myokymia	1.8%
561	Lead Poisoning, Nervous System	1.8%
562	Vestibular Neuronitis	1.8%
563	Somatosensory Disorders	1.8%
564	Neuropathic pain	1.8%
565	Hyperkinesia	1.8%
566	Intention tremor	1.8%
567	Anterior Spinal Artery Syndrome	1.8%
568	Fabry Disease	1.8%
569	Coma, Post-Head Injury	1.8%
570	Lyme Neuroborreliosis	1.7%
571	Cavernous Sinus Thrombosis	1.7%
572	Sagittal Sinus Thrombosis	1.7%
573	Binge Drinking	1.6%
574	Akathisia	1.6%
575	Restlessness	1.6%
576	Psychomotor Agitation	1.6%
577	Prolactinoma	1.6%
578	Growth Hormone-Secreting Pituitary Adenoma	1.6%
579	Menkes Kinky Hair Syndrome	1.6%
580	Multiple Sclerosis, Chronic Progressive	1.6%
581	Multiple Sclerosis, Relapsing-Remitting	1.6%
582	Autistic Disorder	1.6%
583	Asperger Syndrome	1.6%
584	Tarsal Tunnel Syndrome	1.6%
585	Cauda Equina Syndrome	1.6%
586	Hand-Arm Vibration Syndrome	1.5%
587	Myotonic Dystrophy	1.5%
588	Vision Disorders	1.5%
589	Metamorphopsia	1.5%
590	Visual Impairment	1.5%
591	Fibromyalgia	1.5%
592	Optic Neuropathy, Ischemic	1.5%
593	Anterior Ischemic Optic Neuropathy	1.5%
594	Medial Tibial Stress Syndrome	1.5%
595	Facial Hemiatrophy	1.5%
596	Melkersson-Rosenthal Syndrome	1.5%
597	Mitochondrial Myopathies	1.5%
598	Anisocoria	1.5%
599	Confusion	1.5%
600	Facial paralysis	1.5%
601	Lethargy	1.5%
602	Memory Disorders	1.5%
603	Muscle Cramp	1.5%
604	Perceptual Disorders	1.5%
605	Psychomotor Disorders	1.5%
606	Tonic Pupil	1.5%
607	Eosinophilia-Myalgia Syndrome	1.5%
608	Anhedonia	1.5%
609	Disorientation	1.5%
610	Facial Paresis	1.5%
611	Memory Loss	1.5%
612	Hemisensory Neglect	1.5%
613	Dysacusis	1.5%
614	Toxoplasmosis, Congenital	1.5%
615	Anencephaly	1.5%
616	Meningocele	1.5%
617	Muscular Atrophy	1.5%
618	Respiratory Paralysis	1.5%
619	Encephalocele	1.5%
620	Malaria, Cerebral	1.5%
621	Tetany	1.4%
622	Neurocysticercosis	1.4%
623	Zellweger Syndrome	1.4%
624	Nelson Syndrome	1.4%
625	Narcolepsy	1.4%
626	Kleine-Levin Syndrome	1.4%
627	Gait Apraxia	1.4%
628	Diurnal Enuresis	1.3%
629	Hematoma, Subdural, Intracranial	1.3%
630	Hematoma, Subdural, Chronic	1.3%
631	Hematoma, Subdural, Acute	1.3%
632	Sciatic Neuropathy	1.3%
633	Ulnar Neuropathies	1.3%
634	Lesion of Sciatic Nerve	1.3%
635	Ulnar Neuritis	1.3%
636	Radial nerve compression	1.3%
637	Radial Tunnel Syndrome	1.3%
638	Peroneal Neuropathies	1.3%
639	Radial Neuropathy	1.3%
640	Median Neuropathy	1.3%
641	Sciatic Nerve Palsy	1.3%
642	Femoral Neuropathy	1.3%
643	Tibial Neuropathy	1.3%
644	Ulnar Nerve Palsy	1.3%
645	Postural Orthostatic Tachycardia Syndrome	1.3%
646	Radial nerve palsy	1.3%
647	Acoustic Neuroma	1.3%
648	Carpal Tunnel Syndrome	1.3%
649	neurofibroma	1.3%
650	Sciatica	1.3%
651	Duane Retraction Syndrome	1.3%
652	Amyloid Neuropathies, Familial	1.3%
653	Alstrom Syndrome	1.3%
654	Muscle Weakness	1.2%
655	Mobius Syndrome	1.2%
656	Bell Palsy	1.2%
657	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.2%
658	Catatonia	1.2%
659	Herpes Zoster Oticus	1.2%
660	Familial Periodic Paralysis	1.2%
661	Aphonia	1.2%
662	Dysphonia	1.2%
663	Optic Nerve Glioma	1.2%
664	Glycogen storage disease type II	1.1%
665	Waterhouse-Friderichsen Syndrome	1.1%
666	Myalgia	1%
667	Neuronal Ceroid-Lipofuscinoses	1%
668	Thoracic Outlet Syndrome	1%
669	Esotropia	1%
670	Exotropia	1%
671	Hypotension, Orthostatic	1%
672	Sleep Apnea Syndromes	1%
673	Polymyositis	1%
674	Post-Exercise Hypotension	1%
675	Trigeminal Nerve Disorder	1%
676	Dermal Sinus	1%
677	Dysgeusia	1%
678	Formication	1%
679	Hyperalgesia	1%
680	Hyperesthesia	1%
681	Hypesthesia	1%
682	Language Disorders	1%
683	Numbness	1%
684	Paresthesia	1%
685	Paraparesis, Spastic	1%
686	Spina Bifida Cystica	1%
687	Trismus	1%
688	Spina Bifida Occulta	1%
689	Epilepsia Partialis Continua	1%
690	Hypogeusia	1%
691	Meningeal Carcinomatosis	1%
692	Brown-Sequard Syndrome	1%
693	Lissencephaly	1%
694	Polymicrogyria	1%
695	Pachygyria	1%
696	Schizencephaly	1%
697	Lockjaw	1%
698	Allodynia	1%
699	Lead Poisoning, Nervous System, Childhood	1%
700	Lead Poisoning, Nervous System, Adult	1%
701	Periventricular Nodular Heterotopia	1%
702	Ageusia	1%
703	Cataplexy	1%
704	Cubital Tunnel Syndrome	1%
705	Aicardi's syndrome	0.9%
706	Hoarseness	0.9%
707	Cockayne Syndrome	0.9%
708	Classical Lissencephalies and Subcortical Band Heterotopias	0.9%
709	Eye Injuries	0.8%
710	Muscular Dystrophy	0.8%
711	Congenital nystagmus	0.8%
712	Orbital Myositis	0.8%
713	Holoprosencephaly	0.8%
714	Diplopia	0.8%
715	Muscle Rigidity	0.8%
716	Muscle Spasticity	0.8%
717	Scotoma	0.8%
718	Photophobia	0.8%
719	Cogwheel Rigidity	0.8%
720	Hemifacial Spasm	0.8%
721	Amaurosis	0.8%
722	Blindness	0.8%
723	Nuchal Rigidity	0.8%
724	Pyomyositis	0.8%
725	Agnosia	0.8%
726	Apraxias	0.8%
727	Hallucinations	0.8%
728	Hemianopsia	0.8%
729	Hyperacusis	0.8%
730	Tinnitus	0.8%
731	Visual Agnosia	0.8%
732	Anosognosia	0.8%
733	Wernicke-Korsakoff Syndrome	0.8%
734	Phonophobia	0.8%
735	Hearing Loss	0.8%
736	Sarcopenia	0.8%
737	Polyradiculopathy	0.8%
738	Gaucher Disease	0.8%
739	Optic Atrophy, Hereditary, Leber	0.7%
740	Color blindness	0.7%
741	Cri-du-Chat Syndrome	0.7%
742	Down Syndrome	0.7%
743	Trisomy 21	0.7%
744	POEMS Syndrome	0.7%
745	Meningioma	0.7%
746	Williams Syndrome	0.7%
747	Microcephaly	0.7%
748	Macrocephaly	0.7%
749	Hypokalemic periodic paralysis	0.7%
750	Frontotemporal dementia	0.7%
751	Porencephaly	0.7%
752	Kearns-Sayre syndrome	0.6%
753	Sleep Apnea, Obstructive	0.6%
754	Sleep Apnea, Central	0.6%
755	Trigeminal Neuralgia	0.6%
756	Agraphia	0.6%
757	Anomia	0.6%
758	Cluttering	0.6%
759	Language Development Disorders	0.6%
760	Speech Disorders	0.6%
761	Syncope	0.6%
762	Stupor	0.6%
763	Dysgraphia	0.6%
764	Presyncope	0.6%
765	Dyslalia	0.6%
766	Prader-Willi Syndrome	0.6%
767	Niemann-Pick Disease, Type C	0.6%
768	Phantom pain	0.6%
769	Phantom Limb Pain	0.6%
770	Neurofibrosarcoma	0.6%
771	Tay-Sachs Disease	0.6%
772	Eye Burns	0.5%
773	Welander Distal Myopathy	0.5%
774	Amaurosis Fugax	0.5%
775	Blindness, Cortical	0.5%
776	Rett Syndrome	0.5%
777	Deafness	0.5%
778	Hearing Loss, Sudden	0.5%
779	Gerstmann Syndrome	0.5%
780	Hearing Loss, Bilateral	0.5%
781	Hearing Loss, High-Frequency	0.5%
782	Hearing Loss, Mixed Conductive-Sensorineural	0.5%
783	Prosopagnosia	0.5%
784	Apraxia, Ideomotor	0.5%
785	Charles Bonnet Syndrome	0.5%
786	Hearing Loss, Unilateral	0.5%
787	Complete Hearing Loss	0.5%
788	Alien Hand Syndrome	0.5%
789	Deaf Mutism	0.5%
790	Rubinstein-Taybi Syndrome	0.5%
791	Dermatomyositis	0.4%
792	Corneal Scar	0.4%
793	Muscular Dystrophy, Duchenne	0.4%
794	Aphasia	0.4%
795	Articulation Disorders	0.4%
796	Echolalia	0.4%
797	Stuttering	0.4%
798	Dysphasia	0.4%
799	Fragile X Syndrome	0.3%
800	Dysarthria	0.3%
801	Corneal Perforation	0.3%
802	Mucopolysaccharidosis II	0.2%

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