MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Situs Inversus

(UMLS:C0037221)

Definition:: A congenital abnormality in which organs in the THORAX and the ABDOMEN are opposite to their normal positions (situs solitus) due to lateral transposition. Normally the STOMACH and SPLEEN are on the left, LIVER on the right, the three-lobed right lung is on the right, and the two-lobed left lung on the left. Situs inversus has a familial pattern and has been associated with a number of genes related to microtubule-associated proteins.
UMLS ID:: C0037221
MeSH ID:: D012857

Classification:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.810

Synonym(s)

Situs Inversus

Abdominal situs inversus

Complete transposition

SITUS INVERSUS

Situs Ambiguus

Situs Inversus Viscerum

Situs inversus

Situs inversus visceralis

Situs inversus viscerum

10.

Situs transversus

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Paroxetine	FAERS: 5		US FAERS
2	Atorvastatin			OFFSIDES
3	Lidoderm		9856732	CTD
4	Lisinopril			OFFSIDES
5	Sumatriptan			OFFSIDES
6	Warfarin		8025399	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Abnormalities, Drug-Induced	42.9%
2	Beckwith-Wiedemann Syndrome	35.6%
3	Wolf-Hirschhorn Syndrome	35.6%
4	Prune Belly Syndrome	31%
5	Twins, Conjoined	31%
6	Waardenburg Syndrome	31%
7	Eye Abnormalities	30%
8	Holoprosencephaly	30%
9	Cardiovascular Abnormalities	30%
10	Smith-Magenis syndrome	28.8%
11	Skin Abnormalities	28.6%
12	Lymphatic Abnormalities	28.6%
13	Congenital Microtia	28.6%
14	Cri-du-Chat Syndrome	28.2%
15	Down Syndrome	28.2%
16	Trisomy 21	28.2%
17	Anencephaly	27.7%
18	Congenital diaphragmatic hernia	27.6%
19	Aicardi's syndrome	24.9%
20	Rubinstein-Taybi Syndrome	23.7%
21	Ectodermal Dysplasia	23.6%
22	Aplasia Cutis Congenita	23.6%
23	Prader-Willi Syndrome	23.3%
24	Genetic Diseases, Inborn	23.1%
25	Maxillofacial Abnormalities	22.4%
26	Dural Arteriovenous Fistula	22.4%
27	CHARGE Syndrome	22.4%
28	Urogenital Abnormalities	22.2%
29	Anophthalmos	20.9%
30	Anus, Imperforate	20.9%
31	Hydranencephaly	20.9%
32	Microphthalmos	20.9%
33	Neural Tube Defects	20.9%
34	Tethered Cord Syndrome	20.9%
35	Iniencephaly	20.9%
36	Craniorachischisis	20.9%
37	Limb Deformities, Congenital	20.9%
38	Exencephaly	20.9%
39	Septo-Optic Dysplasia	20.9%
40	Craniofacial Abnormalities	20.9%
41	Cortical Dysplasia	20.9%
42	Malformations of Cortical Development	20.9%
43	Anorectal Malformations	20.9%
44	Bloom Syndrome	20.5%
45	Microcephaly	18.8%
46	Macrocephaly	18.8%
47	Nail-Patella Syndrome	18.1%
48	Xeroderma	17.8%
49	Mobius Syndrome	17.8%
50	Porencephaly	17.6%
51	Marfan Syndrome	17.4%
52	Classical Lissencephalies and Subcortical Band Heterotopias	16.9%
53	Amelia	16.9%
54	Arachnodactyly	16.9%
55	Ectopia Cordis	16.9%
56	Ectromelia	16.9%
57	Hemimelia	16.9%
58	Meningomyelocele	16.9%
59	Phocomelia	16.9%
60	Sirenomelia	16.9%
61	Spina Bifida	16.9%
62	Polydactyly	16.9%
63	Brachydactyly	16.9%
64	Plagiocephaly	16.9%
65	Lower Extremity Deformities, Congenital	16.9%
66	Upper Extremity Deformities, Congenital	16.9%
67	Single umbilical artery	16.9%
68	Craniosynostosis	16.5%
69	Syndactyly	16.5%
70	Brachycephaly	16.5%
71	Fragile X Syndrome	16.3%
72	Scimitar Syndrome	16.3%
73	Polycystic Kidney Diseases	15.9%
74	Williams Syndrome	15.9%
75	Acrocephalosyndactylia	15.8%
76	Blepharophimosis	15.8%
77	Laryngostenosis	15.8%
78	Mouth Abnormalities	15.8%
79	Esophageal Atresia	15.5%
80	Intestinal Atresia	15.5%
81	Horseshoe Kidney	15.5%
82	Pectus excavatum	15.5%
83	Klippel-Feil Syndrome	15.4%
84	Gastroschisis	15.4%
85	Synostosis	15.4%
86	Primary Ciliary Dyskinesia	15.3%
87	Acrodermatitis	15.3%
88	Lymphangiectasis, Intestinal	15.3%
89	Gianotti-Crosti Syndrome	15.3%
90	Alstrom Syndrome	15.1%
91	Fetal Diseases	15%
92	Kartagener Syndrome	15%
93	Dermal Sinus	14.9%
94	Spina Bifida Cystica	14.9%
95	Spina Bifida Occulta	14.9%
96	Lissencephaly	14.9%
97	Polymicrogyria	14.9%
98	Pachygyria	14.9%
99	Schizencephaly	14.9%
100	Periventricular Nodular Heterotopia	14.9%
101	Poland Syndrome	14.6%
102	Noonan Syndrome	14.4%
103	Cockayne Syndrome	14.4%
104	Abdominal Cramps	14.3%
105	Amniotic Band Syndrome	14.3%
106	Asphyxia Neonatorum	14.3%
107	Infant, Premature, Diseases	14.3%
108	Infantile Colic	14.3%
109	Retinal Dysplasia	14%
110	Turner Syndrome	13.9%
111	Aniridia	13.8%
112	Jaw Abnormalities	13.7%
113	Cleft Palate	13.5%
114	Epidermolysis Bullosa	13.5%
115	Abnormalities, Radiation-Induced	13.5%
116	Smith-Lemli-Opitz Syndrome	13.1%
117	Polycystic Kidney, Autosomal Dominant	13.1%
118	Klinefelter Syndrome	12.8%
119	Arthrogryposis	12.7%
120	Choanal Atresia	12.7%
121	Tracheobronchomegaly	12.7%
122	Laryngocele	12.7%
123	Aortic coarctation	12.6%
124	Cor Triatriatum	12.6%
125	Coronary Vessel Anomalies	12.6%
126	Dental Enamel Hypoplasia	12.6%
127	Patent ductus arteriosus	12.6%
128	Ebstein Anomaly	12.6%
129	Heart Septal Defects	12.6%
130	Hypodontia	12.6%
131	Macrostomia	12.6%
132	Meningocele	12.6%
133	Microstomia	12.6%
134	Tetralogy of Fallot	12.6%
135	Transposition of Great Vessels	12.6%
136	Hypoplastic Left Heart Syndrome	12.6%
137	May-Thurner Syndrome	12.6%
138	Encephalocele	12.6%
139	Ichthyosis, X-Linked	12.5%
140	Choledochal Cyst	12.5%
141	Craniofacial Dysostosis	12.5%
142	Hermaphroditism	12.5%
143	Disorders of Sex Development	12.5%
144	Wolff-Parkinson-White Syndrome	12.4%
145	Cryptorchidism	12.3%
146	Hypospadias	12.3%
147	Micrognathism	12.3%
148	Pierre Robin Syndrome	12.3%
149	Central Nervous System Cysts	12.2%
150	Dandy-Walker Syndrome	12.2%
151	POEMS Syndrome	12%
152	Cystic Fibrosis	11.4%
153	Aortopulmonary Septal Defect	11.1%
154	Double Outlet Right Ventricle	11.1%
155	Endocardial Cushion Defects	11.1%
156	Myocardial bridging	11.1%
157	Aorticopulmonary Septal Defect	11.1%
158	Charcot-Marie-Tooth Disease	11%
159	Antley-Bixler Syndrome Phenotype	11%
160	Hyperkeratosis, Epidermolytic	10.9%
161	Retrognathia	10.8%
162	Laryngomalacia	10.5%
163	Truncus Arteriosus, Persistent	10.4%
164	Goldenhar Syndrome	10.4%
165	Familial Mediterranean Fever	10.3%
166	Pectus carinatum	10.3%
167	Sjogren-Larsson Syndrome	10.3%
168	Kallmann Syndrome	10.2%
169	Bladder Exstrophy	10.2%
170	Epispadias	10.2%
171	Pseudoxanthoma Elasticum	10.1%
172	Multicystic Dysplastic Kidney	10.1%
173	Dextrocardia	10.1%
174	Long QT Syndrome	10.1%
175	Platybasia	10.1%
176	Tricuspid Atresia	10.1%
177	Arrhythmogenic Right Ventricular Dysplasia	10.1%
178	Gonadal Dysgenesis	10%
179	Neoplastic Syndromes, Hereditary	10%
180	Bronchomalacia	10%
181	Adrenogenital Syndrome	10%
182	Tracheomalacia	10%
183	Ovotesticular Disorders of Sex Development	10%
184	Hyperandrogenism	9.7%
185	Prognathism	9.6%
186	Anemia, Neonatal	9.3%
187	Meconium Aspiration Syndrome	9.3%
188	Multiple Epiphyseal Dysplasia	9.3%
189	Osteochondrodysplasias	9.3%
190	Pelger-Huet Anomaly	9.3%
191	Persistent Fetal Circulation Syndrome	9.3%
192	Werner Syndrome	9.3%
193	Myasthenic Syndromes, Congenital	9.3%
194	Umbilical hernia	9.1%
195	Xeroderma Pigmentosum	9%
196	Mandibulofacial Dysostosis	8.9%
197	Romano-Ward Syndrome	8.9%
198	Tuberous Sclerosis	8.7%
199	Talipes	8.4%
200	Zellweger Syndrome	8.4%
201	Rett Syndrome	8.2%
202	Refsum Disease	8.1%
203	Congenital clubfoot	8.1%
204	Vertical Talus	8.1%
205	Anemia, Sickle Cell	8%
206	Thalassemia	8%
207	Muscular Dystrophy, Duchenne	8%
208	Basal Cell Nevus Syndrome	7.9%
209	Dwarfism	7.3%
210	Neonatal Abstinence Syndrome	7.1%
211	Albinism	7.1%
212	Paralysis, Obstetric	7%
213	Retinopathy of Prematurity	7%
214	Fetal Growth Retardation	6.9%
215	Muscular Dystrophy	6.8%
216	Osteogenesis Imperfecta	6.8%
217	Fetal Hypoxia	6.8%
218	Congenital nystagmus	6.8%
219	Fetal Alcohol Spectrum Disorders	6.8%
220	Mucopolysaccharidosis II	6.8%
221	Amino Acid Metabolism, Inborn Errors	6.8%
222	Carbohydrate Metabolism, Inborn Errors	6.8%
223	Metal Metabolism, Inborn Errors	6.8%
224	Progeria	6.8%
225	Lysosomal Storage Diseases	6.8%
226	Cytochrome-c Oxidase Deficiency	6.8%
227	Peroxisomal Disorders	6.8%
228	Toxoplasmosis, Congenital	6.8%
229	Bronchopulmonary Dysplasia	6.7%
230	Syphilis, Congenital	6.7%
231	Sickle Cell Trait	6.5%
232	Arteriovenous fistula	6.4%
233	Menkes Kinky Hair Syndrome	5.9%
234	Neuronal Ceroid-Lipofuscinoses	5.8%
235	Wiskott-Aldrich Syndrome	5.7%
236	Alkaptonuria	5.6%
237	Glycogen Storage Disease	5.6%
238	Hypophosphatasia	5.6%
239	Propionic acidemia	5.6%
240	Autoimmune Lymphoproliferative Syndrome	5.6%
241	Dihydropyrimidine Dehydrogenase Deficiency	5.6%
242	Cystinosis	5.6%
243	Congenital Hyperinsulinism	5.5%
244	Chorioamnionitis	5.4%
245	Angioedemas, Hereditary	5.4%
246	Respiratory Distress Syndrome, Newborn	5.3%
247	Cutis Laxa	5.2%
248	Retinitis Pigmentosa	5.1%
249	Pigmentary retinopathy	5.1%
250	Porokeratosis	5.1%
251	Keratoderma, Palmoplantar	5.1%
252	Chronic granulomatous disease	5%
253	Welander Distal Myopathy	5%
254	Myotonic Dystrophy	5%
255	Glycogen Storage Disease Type I	4.9%
256	Glycogen Storage Disease Type V	4.9%
257	Mucopolysaccharidosis III	4.9%
258	Glycogen storage disease type II	4.8%
259	Acute Chest Syndrome	4.8%
260	Galactosemias	4.7%
261	Urea Cycle Disorders, Inborn	4.7%
262	Tyrosinemias	4.7%
263	Adrenoleukodystrophy	4.7%
264	Fabry Disease	4.6%
265	Denys-Drash Syndrome	4.6%
266	Amyloid Neuropathies, Familial	4.5%
267	Hepatolenticular Degeneration	4.4%
268	Hydrops Fetalis	4.4%
269	Hyaline Membrane Disease	4.2%
270	Duane Retraction Syndrome	4.2%
271	Hypolipoproteinemias	4.1%
272	Papillon-Lefevre Disease	4.1%
273	Hyperlipidemia, Familial Combined	4.1%
274	Porphyrias, Hepatic	4.1%
275	Hyperlipoproteinemia Type III	4.1%
276	Optic Atrophy, Hereditary, Leber	4.1%
277	Hyperphosphaturia	4.1%
278	Gaucher Disease	4.1%
279	Peutz-Jeghers Syndrome	4%
280	Myotonia Congenita	4%
281	Thrombasthenia	4%
282	Antithrombin III Deficiency	4%
283	Protein C Deficiency	4%
284	Brain Diseases, Metabolic, Inborn	4%
285	Afibrinogenemia	4%
286	Dystonia Musculorum Deformans	4%
287	Factor VII Deficiency	4%
288	Factor X Deficiency	4%
289	Factor XII Deficiency	4%
290	Hemophilia A	4%
291	Leukomalacia, Periventricular	4%
292	Activated Protein C Resistance	4%
293	Factor II deficiency	4%
294	Factor VIII Deficiency	4%
295	Factor V deficiency	4%
296	Factor XI Deficiency	4%
297	Hypoprothrombinemias	4%
298	Fanconi Anemia	4%
299	Nesidioblastosis	4%
300	Lafora Disease	4%
301	Unverricht-Lundborg Syndrome	4%
302	Anemia, Diamond-Blackfan	3.9%
303	Homocystinuria	3.9%
304	Leigh Disease	3.9%
305	Tay-Sachs Disease	3.9%
306	Canavan Disease	3.8%
307	Alexander Disease	3.8%
308	Ophthalmia Neonatorum	3.8%
309	Hypoalphalipoproteinemias	3.7%
310	Carbamoyl-Phosphate Synthase I Deficiency Disease	3.6%
311	Niemann-Pick Disease, Type C	3.6%
312	Multiple Endocrine Neoplasia	3.5%
313	Ataxia Telangiectasia	3.4%
314	Congenital Hypothyroidism	3.4%
315	Familial Periodic Paralysis	3.4%
316	Dermatitis, Atopic	3.4%
317	Lactose Intolerance	3.3%
318	Variegate Porphyria	3.3%
319	Acute intermittent porphyria	3.3%
320	Porphyria Cutanea Tarda	3.3%
321	Hyperhomocysteinemia	3.3%
322	Renal Aminoacidurias	3.3%
323	Fanconi Syndrome	3.3%
324	Pseudohypoaldosteronism	3.3%
325	Liddle Syndrome	3.3%
326	Hyperlipoproteinemia Type IV	3.3%
327	Hyperlipoproteinemia Type V	3.3%
328	Hypokalemic periodic paralysis	3%
329	Cystinuria	2.9%
330	Kernicterus	2.9%
331	Behcet Syndrome	2.9%
332	Gout	2.8%
333	Multiple Endocrine Neoplasia Type 1	2.8%
334	Pseudohypoparathyroidism	2.8%
335	Friedreich Ataxia	2.7%
336	Renal tubular acidosis	2.7%
337	Huntington Disease	2.5%
338	Arthritis, Gouty	2.5%
339	Familial Hypophosphatemic Rickets	2.2%
340	Nephroblastoma	2.2%
341	Glycosuria, Renal	2%
342	Adenomatous Polyposis Coli	2%
343	MELAS Syndrome	1.6%

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