MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Neurosyphilis

(UMLS:C0027927)

Definition:: Infections of the central nervous system caused by TREPONEMA PALLIDUM which present with a variety of clinical syndromes. The initial phase of infection usually causes a mild or asymptomatic meningeal reaction. The meningovascular form may present acutely as BRAIN INFARCTION. The infection may also remain subclinical for several years. Late syndromes include general paresis; TABES DORSALIS; meningeal syphilis; syphilitic OPTIC ATROPHY; and spinal syphilis. General paresis is characterized by progressive DEMENTIA; DYSARTHRIA; TREMOR; MYOCLONUS; SEIZURES; and Argyll-Robertson pupils. (Adams et al., Principles of Neurology, 6th ed, pp722-8)
UMLS ID:: C0027927
MeSH ID:: D009494

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.200.750|C01.252.400.840.744.456|C01.252.847.840.744.456

Classification 2:

Name:

Nervous System Diseases
MeSH Tree Number(s):: C10.228.228.180.600

Synonym(s)

Neurosyphilis

NEUROSYPHILIS

Neurosyphilis, NOS

Neurosyphilis, unspecified

Syphilis of central nervous system

Syphilis of central nervous system, NOS

central nervous system; syphilitic

cerebrospinal syphilis

cerebrospinal; syphilitic

10.

cns syphilis

11.

nervous system; syphilitic

12.

neurosyphilis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Acyclovir	FAERS: 2		US FAERS
2	Finasteride	FAERS: 2		US FAERS
3	Amoxicillin	FAERS: 1		US FAERS
4	Dexamethasone	FAERS: 1		US FAERS
5	Dimethyl Fumarate	FAERS: 1		US FAERS
6	Doxycycline	FAERS: 1		US FAERS
7	Emtricitabine, Tenofovir Disoproxil Fumarate Drug Combination	FAERS: 1		US FAERS
8	MDV 3100	FAERS: 1		US FAERS
9	Methylprednisolone	FAERS: 1		US FAERS
10	Rivastigmine	FAERS: 1		US FAERS
11	Sulfamethoxazole	FAERS: 1		US FAERS
12	Triumeq	FAERS: 1		US FAERS
13	apremilast	FAERS: 1		US FAERS
14	rofecoxib	FAERS: 1		US FAERS
15	Didanosine			OFFSIDES
16	Mefenamic Acid			OFFSIDES
17	Penicillin G		3827674	CTD
18	Tenofovir			OFFSIDES
19	abacavir			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Lyme Neuroborreliosis	44.9%
2	Borrelia Infections	40.2%
3	Leptospirosis	40.2%
4	Syphilis, Congenital	38.6%
5	Meningitis, Bacterial	38.1%
6	Lyme Disease	33.2%
7	Relapsing Fever	33.2%
8	Tuberculosis, Meningeal	32.4%
9	Meningitis, Listeria	30.8%
10	Meningitis, Haemophilus	30.5%
11	Gram-Positive Bacterial Infections	29.6%
12	Meningitis, Pneumococcal	28.9%
13	Human Ehrlichiosis	25.8%
14	Skin Diseases, Bacterial	25.5%
15	Bacteremia	25.3%
16	Erythema Chronicum Migrans	25.1%
17	Bacterial Vaginosis	24.5%
18	Bordetella Infections	24%
19	Brucellosis	24%
20	Campylobacter infection	24%
21	Enterobacteriaceae Infections	24%
22	Pseudomonas Infections	24%
23	Q Fever	24%
24	Vibrio Infections	24%
25	Helicobacter Infections	24%
26	Neisseriaceae Infections	24%
27	Burkholderia Infections	24%
28	Flavobacteriaceae Infections	24%
29	Moraxellaceae Infections	24%
30	Burkholderia cepacia Infection	24%
31	Human anaplasmosis	22.9%
32	Bacterial Endocarditis	22.5%
33	Japanese Spotted Fever	22.3%
34	Tuberculosis, Central Nervous System	22.1%
35	Pneumonia, Bacterial	21.2%
36	Brain Abscess	21%
37	Gram-Negative Bacterial Infections	20.7%
38	Erysipelas	20.6%
39	Staphylococcal Skin Infections	20.6%
40	Chlamydia Infections	20.5%
41	Gonorrhea	20.5%
42	Meningoencephalitis	20.3%
43	Epidural Abscess	20.3%
44	Central Nervous System Bacterial Infections	20%
45	Encephalomyelitis	19.8%
46	Central Nervous System Fungal Infections	19.8%
47	Syphilis	19.4%
48	Impetigo	19.3%
49	Erythrasma	18.8%
50	Ecthyma	18.4%
51	Subacute Bacterial Endocarditis	18.4%
52	Mycoses	18.2%
53	Infection	18.2%
54	Mycetoma	18.1%
55	Actinomycetales Infections	17.5%
56	Clostridium Infections	17.5%
57	Listeriosis	17.5%
58	Staphylococcal Infections	17.5%
59	Streptococcal Infections	17.5%
60	Bacillaceae Infections	17.5%
61	Clostridium difficile infection	17.5%
62	Rocky Mountain Spotted Fever	17%
63	Myelitis	16.3%
64	Pertussis	15.5%
65	Acinetobacter Infections	15.5%
66	Bacteroides Infections	15.5%
67	Cholera	15.5%
68	Escherichia coli Infections	15.5%
69	Haemophilus Infections	15.5%
70	Klebsiella Infections	15.5%
71	Meningococcal Infections	15.5%
72	Mycoplasma Infections	15.5%
73	Pasteurella Infections	15.5%
74	Proteus Infections	15.5%
75	Rickettsia Infections	15.5%
76	Salmonella infections	15.5%
77	Scrub Typhus	15.5%
78	Serratia Infections	15.5%
79	Ureaplasma Infections	15.5%
80	Central Nervous System Infection	15.3%
81	Rhinoscleroma	15.2%
82	Erysipelothrix infection	15.2%
83	Hidradenitis Suppurativa	15.2%
84	Waterhouse-Friderichsen Syndrome	15.1%
85	Ulcerative stomatitis	15.1%
86	Meningitis, Fungal	14.9%
87	Neuroaspergillosis	14.9%
88	Neurosyphilis	14.5%
89	Staphylococcal Scalded Skin Syndrome	14.4%
90	Prion Diseases	14.3%
91	Lymphogranuloma Venereum	14.2%
92	Hordeolum	13.6%
93	Bacterial conjunctivitis	13.5%
94	Ophthalmia Neonatorum	13%
95	Trachoma	13%
96	Furunculosis	13%
97	furuncle	13%
98	Toxoplasmosis, Cerebral	12.9%
99	Meningitis, Cryptococcal	12.7%
100	Subdural Effusion	12.4%
101	Actinomycosis	11.6%
102	Corynebacterium Infections	11.6%
103	Gas Gangrene	11.6%
104	Mycobacterium Infections	11.6%
105	Nocardia Infections	11.6%
106	Pneumococcal Infections	11.6%
107	Scarlet Fever	11.6%
108	Tetanus	11.6%
109	Pulmonary Nocardiosis	11.6%
110	carbuncle	11.4%
111	Dermatomycoses	11.3%
112	Psittacosis	11.3%
113	Paratyphoid Fever	11.3%
114	Plague	11.3%
115	Typhoid Fever	11.3%
116	TYPHUS	11.3%
117	Yersinia pseudotuberculosis Infections	11.3%
118	Bubonic Plague	11.3%
119	Dysentery, Bacillary	11.1%
120	Cerebral Ventriculitis	10.8%
121	Botulism	10.7%
122	Poliomyelitis	10.2%
123	Aspergillosis	9.9%
124	Brain Diseases	9.9%
125	Candidiasis	9.9%
126	Coccidioidomycosis	9.9%
127	Histoplasmosis	9.9%
128	Meningitis	9.9%
129	Movement Disorders	9.9%
130	Pachymeningitis	9.9%
131	Paracoccidioidomycosis	9.9%
132	Pelvic Infection	9.9%
133	Spinal Cord Diseases	9.9%
134	Wound Infection	9.9%
135	Zygomycosis	9.9%
136	Soft Tissue Infection	9.9%
137	Community-Acquired Infections	9.9%
138	Phaeohyphomycosis	9.9%
139	Pneumocystis Infections	9.9%
140	Ocular Motility Disorders	9.8%
141	Cyclophoria	9.8%
142	Candidiasis, Chronic Mucocutaneous	9.8%
143	Cutaneous Candidiasis	9.8%
144	Salmonella Infections, Animal	9.7%
145	Panophthalmitis	9.6%
146	Erythema Induratum	9.6%
147	Multiple System Atrophy	9.5%
148	Salmonella food poisoning	9.4%
149	Pneumocephalus	9.4%
150	Joint Tuberculosis	9.4%
151	Tuberculosis, Osteoarticular	9.4%
152	Bone Tuberculosis	9.4%
153	Creutzfeldt-Jakob disease	9.3%
154	Lupus Vasculitis, Central Nervous System	9.2%
155	Leukoencephalopathy, Progressive Multifocal	9.1%
156	Diphtheria	8.7%
157	Leprosy	8.7%
158	Mycobacterium Infections, Nontuberculous	8.7%
159	Tuberculosis	8.7%
160	Mycobacterium abscessus Infection	8.7%
161	Candidemia	8.6%
162	Eye Infection	8.5%
163	Respiratory Tract Infections	8.5%
164	Rheumatic Fever	8.5%
165	Fungemia	8.4%
166	Bone Diseases, Infectious	8.3%
167	Otomycosis	8.3%
168	Pregnancy Complications, Infectious	8.3%
169	Skin Diseases, Infectious	8.3%
170	Limbic Encephalitis	8.3%
171	Enterocolitis, Pseudomembranous	8.3%
172	pseudomembranous colitis	8.3%
173	Arthritis, Infectious	8.2%
174	Piedra	8.2%
175	Suppuration	8.2%
176	Cross Infection	8.2%
177	Septicemia	8.2%
178	Sepsis	8.2%
179	Parkinsonian Disorders	8.1%
180	Scrapie	8%
181	Stiff-Person Syndrome	7.9%
182	Myelitis, Transverse	7.9%
183	Blastomycosis	7.8%
184	Lewy Body Disease	7.8%
185	Opportunistic Infections	7.5%
186	Cellulitis	7.4%
187	Rheumatic Heart Disease	7.4%
188	Subacute Sclerosing Panencephalitis	7.4%
189	Parkinson Disease	7.2%
190	Mycobacterium avium-intracellulare Infection	7.2%
191	Lymph Node Tuberculosis	7.2%
192	Tuberculosis, Miliary	7.2%
193	Tuberculosis, Multidrug-Resistant	7.2%
194	Leprosy, Multibacillary	7.2%
195	Latent Tuberculosis	7.2%
196	Lung Diseases, Fungal	7.2%
197	Urinary tract infection	7.1%
198	Spinal Muscular Atrophy	7%
199	Progressive Muscular Atrophy	7%
200	Subacute Combined Degeneration	7%
201	Dandy-Walker Syndrome	7%
202	Chromoblastomycosis	6.9%
203	Dermatophytosis	6.9%
204	Sporotrichosis	6.9%
205	Tinea	6.9%
206	Tinea Versicolor	6.9%
207	Trichophytosis	6.9%
208	Invasive Pulmonary Aspergillosis	6.9%
209	Hyalohyphomycosis	6.9%
210	Endotoxemia	6.9%
211	Spinal Cord Injuries	6.8%
212	Asterixis	6.6%
213	Ballismus	6.6%
214	Amyotrophic Lateral Sclerosis	6.5%
215	Progressive supranuclear palsy	6.5%
216	Borderline leprosy	6.5%
217	Leprosy, Lepromatous	6.5%
218	Tuberculoid leprosy	6.5%
219	Extensively Drug-Resistant Tuberculosis	6.5%
220	Tuberculosis, Spinal	6.5%
221	Meige Syndrome	6.5%
222	Sexually Transmitted Diseases	6.4%
223	Dementia, Vascular	6.4%
224	Striatonigral Degeneration	6.3%
225	Tuberculosis, Gastrointestinal	6.1%
226	Dystonia Musculorum Deformans	6.1%
227	Cranial nerve diseases	6.1%
228	Demyelinating Diseases	6.1%
229	Demyelination	6.1%
230	Neuromuscular Diseases	6.1%
231	Chronobiology Disorders	6.1%
232	Marchiafava-Bignami Disease	6%
233	Chronic Fatigue Syndrome	6%
234	Pseudorabies	5.9%
235	Akinetic Mutism	5.8%
236	Anoxic Encephalopathy	5.8%
237	Arachnoiditis	5.8%
238	Basal Ganglia Diseases	5.8%
239	Brain Damage, Chronic	5.8%
240	Cerebellar Diseases	5.8%
241	Encephalitis	5.8%
242	Encephalomalacia	5.8%
243	Epilepsy	5.8%
244	Hydrocephalus	5.8%
245	Congenital Hydrocephalus	5.8%
246	Hypothalamic Diseases	5.8%
247	Aseptic Meningitis	5.8%
248	Mucormycosis	5.8%
249	Syringomyelia	5.8%
250	Thalamic Diseases	5.8%
251	Intracranial Hypertension	5.8%
252	Aura	5.8%
253	Leukoencephalopathy	5.8%
254	Essential Tremor	5.8%
255	Neuroaxonal Dystrophies	5.8%
256	Familial Tremor	5.8%
257	Headache Disorders	5.8%
258	Intracranial Hypotension	5.8%
259	Brain Edema	5.8%
260	Brain Hypoxia	5.8%
261	Aqueductal Stenosis	5.8%
262	Pneumorrhachis	5.8%
263	Writer's Cramp	5.8%
264	Huntington Disease	5.8%
265	Lemierre Syndrome	5.7%
266	Epilepsy, Post-Traumatic	5.6%
267	Posterior Leukoencephalopathy Syndrome	5.6%
268	Posterior reversible encephalopathy syndrome	5.6%
269	West Nile Fever	5.6%
270	Brain Injuries	5.6%
271	Shy-Drager Syndrome	5.6%
272	Brain Neoplasms	5.6%
273	Spinal Cord Neoplasms	5.6%
274	Motor Neuron Disease	5.6%
275	Basal Ganglia Cerebrovascular Disease	5.6%
276	MPTP Poisoning	5.4%
277	Tuberculosis, Pulmonary	5.3%
278	Ophthalmoplegic Migraine	5.3%
279	Trauma, Nervous System	5.2%
280	Restless Legs Syndrome	5.2%
281	Neuroleptic Malignant Syndrome	5.2%
282	Myelinolysis, Central Pontine	5.2%
283	Akathisia, Drug-Induced	5.2%
284	Pyomyositis	5.1%
285	Nervous System Neoplasms	5.1%
286	Neurologic Manifestations	5.1%
287	Neurotoxicity Syndromes	5.1%
288	Opsoclonus-Myoclonus Syndrome	5.1%
289	Polyradiculoneuropathy	5%
290	Polyradiculoneuritis	5%
291	Brain Diseases, Metabolic	4.9%
292	Oral candidiasis	4.9%
293	Cerebrovascular Disorders	4.9%
294	Endophthalmitis	4.9%
295	Peritonitis	4.9%
296	Cerebrovascular Insufficiency	4.9%
297	Dementia	4.9%
298	Conus Medullaris Syndrome	4.9%
299	Spinal Cord Vascular Diseases	4.9%
300	Leukoencephalitis, Acute Hemorrhagic	4.9%
301	Hepatolenticular Degeneration	4.9%
302	Toxoplasmosis, Congenital	4.9%
303	Osteomyelitis	4.9%
304	Periostitis	4.9%
305	Surgical Wound Infection	4.9%
306	Pulmonary Aspergillosis	4.9%
307	Bronchopulmonary Aspergillosis	4.9%
308	Leukomalacia, Periventricular	4.9%
309	Malaria, Cerebral	4.9%
310	Abscess	4.9%
311	Adnexitis	4.9%
312	Empyema	4.9%
313	Pelvic Inflammatory Disease	4.9%
314	Vascular Headaches	4.8%
315	Neurocysticercosis	4.8%
316	Hypoxia-Ischemia, Brain	4.8%
317	Fusariosis	4.8%
318	Myoclonic Epilepsy	4.8%
319	Epilepsy, Temporal Lobe	4.8%
320	Epilepsy, Rolandic	4.8%
321	Benign Rolandic Epilepsy	4.8%
322	Cerebellar Neoplasms	4.8%
323	Brain Death	4.8%
324	Dyskinesia, Drug-Induced	4.6%
325	Amblyopia	4.5%
326	Friedreich Ataxia	4.5%
327	Sleep Wake Disorders	4.5%
328	Miller Fisher Syndrome	4.4%
329	Autonomic Dysreflexia	4.4%
330	Complex Regional Pain Syndromes	4.4%
331	Superinfection	4.3%
332	Encephalomyelitis, Acute Disseminated	4.3%
333	Corneal Ulcer	4.2%
334	Tinea Capitis	4.2%
335	Onychomycosis	4.2%
336	Central Cord Syndrome	4.2%
337	Puerperal Infection	4.2%
338	Spondylitis	4.2%
339	Appendicitis	4.2%
340	Bacteriuria	4.2%
341	Presenile dementia	4.2%
342	Senile dementia	4.2%
343	Pyuria	4.2%
344	Chorea	4.2%
345	Endotoxic shock	4.2%
346	Septic Shock	4.2%
347	Toxic Shock Syndrome	4.2%
348	Candidiasis, Vulvovaginal	4.1%
349	Basal Ganglia Hemorrhage	4.1%
350	Vasculitis, Central Nervous System	4%
351	Brain Hemorrhage, Traumatic	4%
352	Juvenile Myoclonic Epilepsy	4%
353	Myoclonic Epilepsies, Progressive	4%
354	Lafora Disease	3.9%
355	Unverricht-Lundborg Syndrome	3.9%
356	Carotid Artery Injuries	3.9%
357	Cerebral Palsy	3.9%
358	Epilepsies, Partial	3.9%
359	Epilepsy, Generalized	3.9%
360	Pseudotumor Cerebri	3.9%
361	Psoas Abscess	3.9%
362	Hypertensive Encephalopathy	3.9%
363	Simple Partial Seizures	3.9%
364	Abdominal Abscess	3.9%
365	Epilepsy, Reflex	3.9%
366	Headache Disorders, Primary	3.9%
367	Headache Disorders, Secondary	3.9%
368	Medication overuse headache	3.9%
369	Canavan Disease	3.8%
370	Alexander Disease	3.8%
371	Peripheral Nerve Injuries	3.8%
372	Pituitary Adenoma	3.8%
373	Pituitary Neoplasms	3.8%
374	Guillain-Barre Syndrome	3.8%
375	Myasthenia Gravis	3.8%
376	Amnesia, Transient Global	3.8%
377	Tinea Pedis	3.7%
378	Brain Injuries, Diffuse	3.7%
379	Traumatic Brain Injury	3.7%
380	Tuberculosis, Renal	3.7%
381	Cerebellar Ataxia	3.7%
382	Supratentorial Neoplasms	3.7%
383	Torticollis	3.7%
384	Pituitary Apoplexy	3.7%
385	Paraneoplastic Cerebellar Degeneration	3.7%
386	Lambert-Eaton Myasthenic Syndrome	3.6%
387	Arthritis, Reactive	3.6%
388	Brain Infarction	3.6%
389	Putaminal Hemorrhage	3.5%
390	Persistent Vegetative State	3.4%
391	Sleep Disorders, Circadian Rhythm	3.4%
392	Pituitary Diseases	3.4%
393	Infarction, Middle Cerebral Artery	3.3%
394	Infarction, Anterior Cerebral Artery	3.3%
395	Infarction, Posterior Cerebral Artery	3.3%
396	AIDS-Related Opportunistic Infections	3.3%
397	Central Nervous System Cysts	3.3%
398	Dysautonomia	3.3%
399	Vagus Nerve Disorder	3.3%
400	Glossopharyngeal Neuralgia	3.3%
401	Abducens Nerve Diseases	3.3%
402	Heavy Metal Poisoning, Nervous System	3.3%
403	Neuromuscular Junction Diseases	3.3%
404	Tauopathies	3.3%
405	Trochlear Nerve Diseases	3.3%
406	Peripheral Nervous System Diseases	3.3%
407	Progressive bulbar palsy	3.3%
408	Bulbar palsy	3.3%
409	Olfactory Nerve Injuries	3.3%
410	Neuromyelitis Optica	3.2%
411	Carotid Artery Diseases	3.2%
412	Brain Ischemia	3.2%
413	Cerebrovascular accident	3.2%
414	Kluver-Bucy Syndrome	3.2%
415	Vasospasm, Intracranial	3.2%
416	Spinal Cord Ischemia	3.2%
417	Intracranial Arterial Diseases	3.2%
418	Causalgia	3.2%
419	Diverticulitis	3.2%
420	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	3%
421	Ataxia Telangiectasia	3%
422	Cerebral Infarction	3%
423	Brain Stem Infarctions	3%
424	Tardive Dyskinesia	3%
425	Moyamoya Disease	2.9%
426	Facial Nerve Injuries	2.9%
427	Post-Traumatic Headache	2.9%
428	Tension Headache	2.9%
429	Epilepsy, Complex Partial	2.9%
430	Migraine Disorders	2.9%
431	Abdominal Migraine	2.9%
432	Status Migrainosus	2.9%
433	Cervicogenic Headache	2.9%
434	Mitochondrial Encephalomyopathies	2.9%
435	Horner Syndrome	2.9%
436	Lung Abscess	2.8%
437	Myopathy	2.8%
438	Optic Neuropathy	2.8%
439	Diverticulum	2.8%
440	Diverticulosis	2.8%
441	Multiple Sclerosis	2.8%
442	Reye Syndrome	2.8%
443	Intracranial Embolism and Thrombosis	2.8%
444	Facial Nerve Diseases	2.8%
445	Craniocerebral Trauma	2.8%
446	Hepatic Encephalopathy	2.8%
447	Parasomnia	2.8%
448	Dyssomnias	2.8%
449	Adrenoleukodystrophy	2.8%
450	Subarachnoid Hemorrhage, Traumatic	2.8%
451	Carotid Artery, Internal, Dissection	2.8%
452	Discitis	2.8%
453	Mastoiditis	2.8%
454	Petrositis	2.8%
455	Vestibulocochlear Nerve Diseases	2.7%
456	Decerebrate State	2.7%
457	Hemiparesis	2.7%
458	Hydranencephaly	2.7%
459	Meningism	2.7%
460	Neural Tube Defects	2.7%
461	Paresis	2.7%
462	Seizures	2.7%
463	Sensation Disorders	2.7%
464	Tethered Cord Syndrome	2.7%
465	Central Nervous System Neoplasms	2.7%
466	Complex partial seizures	2.7%
467	Iniencephaly	2.7%
468	Craniorachischisis	2.7%
469	Exencephaly	2.7%
470	Monoparesis	2.7%
471	Septo-Optic Dysplasia	2.7%
472	Cortical Dysplasia	2.7%
473	Neurogenic Inflammation	2.7%
474	Gait Disorders, Neurologic	2.7%
475	Neuromuscular Manifestations	2.7%
476	Malformations of Cortical Development	2.7%
477	Diffuse Axonal Injury	2.7%
478	Brain Stem Neoplasms	2.7%
479	Sweating, Gustatory	2.7%
480	Auriculotemporal Syndrome	2.7%
481	Reflex Sympathetic Dystrophy	2.7%
482	Vertebral Artery Dissection	2.7%
483	Nocturnal Myoclonus Syndrome	2.7%
484	Lateral Medullary Syndrome	2.7%
485	Frontotemporal dementia	2.6%
486	Myasthenia Gravis, Autoimmune, Experimental	2.6%
487	Auditory Perceptual Disorders	2.6%
488	MELAS Syndrome	2.6%
489	Brain Concussion	2.6%
490	Tuberous Sclerosis	2.6%
491	Jet Lag Syndrome	2.6%
492	Alice in Wonderland Syndrome	2.5%
493	Ophthalmoplegia	2.5%
494	External Ophthalmoplegia	2.5%
495	Empty Sella Syndrome	2.5%
496	Hyperpituitarism	2.5%
497	Hypopituitarism	2.5%
498	Liver Abscess	2.5%
499	Hypophysitis	2.5%
500	Retropharyngeal Abscess	2.4%
501	Brain Diseases, Metabolic, Inborn	2.4%
502	Pupil Disorders	2.4%
503	Neurobehavioral Manifestations	2.4%
504	Peritonsillar Abscess	2.4%
505	Brain Contusion	2.4%
506	Cerebral Arterial Diseases	2.4%
507	Vertebrobasilar Insufficiency	2.4%
508	Anterior Spinal Artery Syndrome	2.4%
509	Basilar Artery Stenosis	2.4%
510	Vertebral Artery Stenosis	2.4%
511	Intracranial Hemorrhage, Hypertensive	2.4%
512	Transient Cerebral Ischemia	2.4%
513	Cluster Headache	2.4%
514	Migraine with Aura	2.4%
515	Familial Hemiplegic Migraine	2.4%
516	Chronic Paroxysmal Hemicrania	2.4%
517	SUNCT Syndrome	2.4%
518	Paroxysmal Hemicrania	2.4%
519	Paraneoplastic Encephalomyelitis	2.4%
520	Refsum Disease	2.4%
521	Uveomeningoencephalitic Syndrome	2.4%
522	Sturge-Weber Syndrome	2.3%
523	Vertigo	2.3%
524	Alcohol-Induced Disorders, Nervous System	2.3%
525	Charcot-Marie-Tooth Disease	2.3%
526	Acrodynia	2.3%
527	Choroid Plexus Papilloma	2.3%
528	Vocal Cord Paralysis	2.2%
529	Giant Cell Arteritis	2.2%
530	Temporal Arteritis	2.2%
531	Aspergillosis, Allergic Bronchopulmonary	2.2%
532	Wernicke Encephalopathy	2.2%
533	AIDS Dementia Complex	2.2%
534	Brachial Plexus Neuritis	2.2%
535	Neuralgic Amyotrophy	2.2%
536	Voice Disorders	2.1%
537	Voice Disturbance	2.1%
538	Carotid Stenosis	2.1%
539	Intracranial Aneurysm	2.1%
540	Intracranial Arteriosclerosis	2.1%
541	Cerebral Atherosclerosis	2.1%
542	Subarachnoid Hemorrhage	2.1%
543	Cerebral Arteriosclerosis	2.1%
544	Cerebral Hemorrhage	2.1%
545	Smith-Magenis syndrome	2.1%
546	Cerebral Thrombosis	2.1%
547	Intracranial Embolism	2.1%
548	Intracranial Thrombosis	2.1%
549	Dural Arteriovenous Fistula	2.1%
550	Myotonia Congenita	2%
551	Cerebrospinal Fluid Otorrhea	2%
552	Cerebrospinal Fluid Rhinorrhea	2%
553	Neuritis, Autoimmune, Experimental	2%
554	Gait Ataxia	2%
555	Hyperprolactinemia	2%
556	Subclavian Steal Syndrome	2%
557	Pick Disease of the Brain	2%
558	Kernicterus	2%
559	Coma, Post-Head Injury	2%
560	Alcohol Withdrawal Seizures	2%
561	Neuritis	1.9%
562	Polyneuritis	1.9%
563	Radiculitis	1.9%
564	Polyneuropathy	1.9%
565	Mononeuritis	1.9%
566	Mononeuropathies	1.9%
567	Brachial Plexus Neuropathies	1.9%
568	Radiculopathy	1.9%
569	Mononeuropathy Multiplex	1.9%
570	Nerve Root Compression	1.9%
571	Myotonic Dystrophy	1.9%
572	Tarsal Tunnel Syndrome	1.9%
573	Cauda Equina Syndrome	1.9%
574	Hematoma, Subdural	1.8%
575	Hematoma, Epidural, Cranial	1.8%
576	Multiple Sclerosis, Chronic Progressive	1.8%
577	Multiple Sclerosis, Relapsing-Remitting	1.8%
578	Reflex, Abnormal	1.8%
579	Hyporeflexia	1.8%
580	Hyperreflexia	1.8%
581	Carotid Artery Thrombosis	1.8%
582	Akathisia	1.8%
583	Restlessness	1.8%
584	Psychomotor Agitation	1.8%
585	Acromegaly	1.7%
586	Cerebral Amyloid Angiopathy	1.7%
587	Optic Nerve Glioma	1.7%
588	Sinus Thrombosis, Intracranial	1.7%
589	Myositis	1.6%
590	Optic Atrophy	1.6%
591	Optic Neuritis	1.6%
592	Papilledema	1.6%
593	Strabismus	1.6%
594	Tolosa-Hunt Syndrome	1.6%
595	Isaacs syndrome	1.6%
596	Arsenic Poisoning	1.6%
597	Myotonic Disorders	1.6%
598	Myasthenic Syndromes, Congenital	1.6%
599	Diabetic Neuropathies	1.6%
600	Facial Injuries	1.6%
601	Facial Neuralgia	1.6%
602	Diabetic Amyotrophy	1.6%
603	Diabetic Autonomic Neuropathy	1.6%
604	Sleep Talking	1.6%
605	Manganese Poisoning	1.6%
606	Sleep Disorders, Intrinsic	1.6%
607	Orthostatic intolerance	1.6%
608	Alstrom Syndrome	1.6%
609	Anosmia	1.6%
610	Ataxia	1.6%
611	Athetosis	1.6%
612	Catalepsy	1.6%
613	Dystonia	1.6%
614	Hemiplegia	1.6%
615	Locked-In Syndrome	1.6%
616	Meningeal Neoplasms	1.6%
617	Meningomyelocele	1.6%
618	Muscle Hypertonia	1.6%
619	Muscle hypotonia	1.6%
620	Myoclonus	1.6%
621	Myotonia	1.6%
622	Neuralgia	1.6%
623	Paraplegia	1.6%
624	Pseudobulbar Palsy	1.6%
625	Quadriplegia	1.6%
626	Spasm	1.6%
627	Spastic Paraplegia	1.6%
628	Status Epilepticus	1.6%
629	Taste Disorders	1.6%
630	Tremor	1.6%
631	Spina Bifida	1.6%
632	Monoplegia	1.6%
633	Hypokinesia	1.6%
634	Paraparesis	1.6%
635	Bradykinesia	1.6%
636	Waxy flexibility	1.6%
637	Action Tremor	1.6%
638	Resting Tremor	1.6%
639	Dysosmia	1.6%
640	Quadriparesis	1.6%
641	Mercury Poisoning, Nervous System	1.6%
642	Olfaction Disorders	1.6%
643	Myokymia	1.6%
644	Lead Poisoning, Nervous System	1.6%
645	Vestibular Neuronitis	1.6%
646	Somatosensory Disorders	1.6%
647	Neuropathic pain	1.6%
648	Hyperkinesia	1.6%
649	Intention tremor	1.6%
650	Carpal Tunnel Syndrome	1.6%
651	Gait Apraxia	1.6%
652	neurofibroma	1.6%
653	Sciatica	1.6%
654	Fabry Disease	1.6%
655	Hematoma, Subdural, Intracranial	1.6%
656	Hematoma, Subdural, Chronic	1.6%
657	Hematoma, Subdural, Acute	1.6%
658	Cavernous Sinus Thrombosis	1.5%
659	Sagittal Sinus Thrombosis	1.5%
660	Acoustic Neuroma	1.5%
661	Amyloid Neuropathies, Familial	1.5%
662	Hand-Arm Vibration Syndrome	1.5%
663	Galactosemias	1.4%
664	Urea Cycle Disorders, Inborn	1.4%
665	Tyrosinemias	1.4%
666	Vision Disorders	1.4%
667	Metamorphopsia	1.4%
668	Visual Impairment	1.4%
669	Fibromyalgia	1.4%
670	Optic Neuropathy, Ischemic	1.4%
671	Anterior Ischemic Optic Neuropathy	1.4%
672	Medial Tibial Stress Syndrome	1.4%
673	Facial Hemiatrophy	1.4%
674	Melkersson-Rosenthal Syndrome	1.4%
675	Mitochondrial Myopathies	1.4%
676	Anisocoria	1.4%
677	Confusion	1.4%
678	Facial paralysis	1.4%
679	Lethargy	1.4%
680	Memory Disorders	1.4%
681	Muscle Cramp	1.4%
682	Perceptual Disorders	1.4%
683	Psychomotor Disorders	1.4%
684	Tonic Pupil	1.4%
685	Eosinophilia-Myalgia Syndrome	1.4%
686	Anhedonia	1.4%
687	Disorientation	1.4%
688	Facial Paresis	1.4%
689	Memory Loss	1.4%
690	Hemisensory Neglect	1.4%
691	Dysacusis	1.4%
692	Sleep Bruxism	1.4%
693	Anencephaly	1.4%
694	Meningocele	1.4%
695	Muscular Atrophy	1.4%
696	Respiratory Paralysis	1.4%
697	Encephalocele	1.4%
698	Tetany	1.4%
699	Menkes Kinky Hair Syndrome	1.4%
700	Cubital Tunnel Syndrome	1.4%
701	Liver Abscess, Amebic	1.4%
702	Nelson Syndrome	1.4%
703	Prolactinoma	1.4%
704	Growth Hormone-Secreting Pituitary Adenoma	1.4%
705	Homocystinuria	1.3%
706	Leigh Disease	1.3%
707	Sciatic Neuropathy	1.3%
708	Ulnar Neuropathies	1.3%
709	Lesion of Sciatic Nerve	1.3%
710	Ulnar Neuritis	1.3%
711	Radial nerve compression	1.3%
712	Radial Tunnel Syndrome	1.3%
713	Peroneal Neuropathies	1.3%
714	Radial Neuropathy	1.3%
715	Median Neuropathy	1.3%
716	Sciatic Nerve Palsy	1.3%
717	Femoral Neuropathy	1.3%
718	Tibial Neuropathy	1.3%
719	Ulnar Nerve Palsy	1.3%
720	Postural Orthostatic Tachycardia Syndrome	1.3%
721	Radial nerve palsy	1.3%
722	Duane Retraction Syndrome	1.3%
723	Classical Lissencephalies and Subcortical Band Heterotopias	1.2%
724	Consciousness Disorders	1.2%
725	Mental Retardation	1.2%
726	Muscle Weakness	1.2%
727	Depressed Level of Consciousness	1.2%
728	Mental deficiency	1.2%
729	Intellectual Disability	1.2%
730	Mobius Syndrome	1.2%
731	Bell Palsy	1.2%
732	Catatonia	1.2%
733	Herpes Zoster Oticus	1.2%
734	Familial Periodic Paralysis	1.2%
735	Aphonia	1.2%
736	Sleep Deprivation	1.2%
737	Dysphonia	1.2%
738	Thoracic Outlet Syndrome	1.1%
739	Carbamoyl-Phosphate Synthase I Deficiency Disease	1.1%
740	Myalgia	1.1%
741	Esotropia	1.1%
742	Exotropia	1.1%
743	Hypotension, Orthostatic	1.1%
744	Sleep Apnea Syndromes	1.1%
745	Polymyositis	1.1%
746	Post-Exercise Hypotension	1.1%
747	Neuronal Ceroid-Lipofuscinoses	1.1%
748	Disorders of Excessive Somnolence	1.1%
749	Sleep Initiation and Maintenance Disorders	1.1%
750	Night Terrors	1.1%
751	Somnambulism	1.1%
752	Trigeminal Nerve Disorder	1.1%
753	Transient Insomnia	1.1%
754	Sleep Paralysis	1.1%
755	Chronic Insomnia	1.1%
756	REM Sleep Behavior Disorder	1.1%
757	Hypersomnia	1.1%
758	Dermal Sinus	1.1%
759	Dysgeusia	1.1%
760	Formication	1.1%
761	Hyperalgesia	1.1%
762	Hyperesthesia	1.1%
763	Hypesthesia	1.1%
764	Language Disorders	1.1%
765	Numbness	1.1%
766	Paresthesia	1.1%
767	Paraparesis, Spastic	1.1%
768	Spina Bifida Cystica	1.1%
769	Trismus	1.1%
770	Spina Bifida Occulta	1.1%
771	Epilepsia Partialis Continua	1.1%
772	Hypogeusia	1.1%
773	Meningeal Carcinomatosis	1.1%
774	Brown-Sequard Syndrome	1.1%
775	Lissencephaly	1.1%
776	Polymicrogyria	1.1%
777	Pachygyria	1.1%
778	Schizencephaly	1.1%
779	Lockjaw	1.1%
780	Allodynia	1.1%
781	Lead Poisoning, Nervous System, Childhood	1.1%
782	Lead Poisoning, Nervous System, Adult	1.1%
783	Periventricular Nodular Heterotopia	1.1%
784	Ageusia	1.1%
785	Alexia	1.1%
786	Dyslexia	1.1%
787	Zellweger Syndrome	1%
788	Kearns-Sayre syndrome	1%
789	Optic Atrophy, Hereditary, Leber	1%
790	Glycogen storage disease type II	1%
791	Aicardi's syndrome	1%
792	Hoarseness	1%
793	Cockayne Syndrome	1%
794	Alcohol Withdrawal Delirium	1%
795	Neurofibrosarcoma	1%
796	Polyradiculopathy	1%
797	Eye Injuries	1%
798	Muscular Dystrophy	0.9%
799	Congenital nystagmus	0.9%
800	Orbital Myositis	0.9%
801	Diplopia	0.9%
802	Muscle Rigidity	0.9%
803	Muscle Spasticity	0.9%
804	Scotoma	0.9%
805	Photophobia	0.9%
806	Cogwheel Rigidity	0.9%
807	Hemifacial Spasm	0.9%
808	Amaurosis	0.9%
809	Blindness	0.9%
810	Nuchal Rigidity	0.9%
811	Agnosia	0.9%
812	Apraxias	0.9%
813	Hallucinations	0.9%
814	Hemianopsia	0.9%
815	Hyperacusis	0.9%
816	Tinnitus	0.9%
817	Visual Agnosia	0.9%
818	Anosognosia	0.9%
819	Wernicke-Korsakoff Syndrome	0.9%
820	Phonophobia	0.9%
821	Hearing Loss	0.9%
822	Sarcopenia	0.9%
823	Holoprosencephaly	0.9%
824	Gaucher Disease	0.8%
825	Amnesia	0.8%
826	Delirium	0.8%
827	Dissociative Amnesia	0.8%
828	Color blindness	0.8%
829	Global Amnesia	0.8%
830	Cri-du-Chat Syndrome	0.8%
831	Down Syndrome	0.8%
832	Trisomy 21	0.8%
833	POEMS Syndrome	0.8%
834	Meningioma	0.8%
835	Williams Syndrome	0.8%
836	Microcephaly	0.8%
837	Macrocephaly	0.8%
838	Hypokalemic periodic paralysis	0.8%
839	Sleep Apnea, Obstructive	0.8%
840	Sleep Apnea, Central	0.8%
841	Porencephaly	0.8%
842	Narcolepsy	0.8%
843	Trigeminal Neuralgia	0.8%
844	Kleine-Levin Syndrome	0.8%
845	Agraphia	0.8%
846	Anomia	0.8%
847	Cluttering	0.8%
848	Language Development Disorders	0.8%
849	Speech Disorders	0.8%
850	Syncope	0.8%
851	Stupor	0.8%
852	Dysgraphia	0.8%
853	Presyncope	0.8%
854	Dyslalia	0.8%
855	Tay-Sachs Disease	0.8%
856	Prader-Willi Syndrome	0.7%
857	Niemann-Pick Disease, Type C	0.7%
858	Phantom pain	0.7%
859	Phantom Limb Pain	0.7%
860	Eye Burns	0.7%
861	Welander Distal Myopathy	0.7%
862	Amaurosis Fugax	0.7%
863	Blindness, Cortical	0.7%
864	Dyscalculia	0.7%
865	Rett Syndrome	0.7%
866	Deafness	0.7%
867	Hearing Loss, Sudden	0.7%
868	Gerstmann Syndrome	0.7%
869	Hearing Loss, Bilateral	0.7%
870	Hearing Loss, High-Frequency	0.7%
871	Hearing Loss, Mixed Conductive-Sensorineural	0.7%
872	Prosopagnosia	0.7%
873	Apraxia, Ideomotor	0.7%
874	Charles Bonnet Syndrome	0.7%
875	Hearing Loss, Unilateral	0.7%
876	Complete Hearing Loss	0.7%
877	Alien Hand Syndrome	0.7%
878	Deaf Mutism	0.7%
879	Cataplexy	0.7%
880	Aphasia	0.7%
881	Articulation Disorders	0.7%
882	Echolalia	0.7%
883	Stuttering	0.7%
884	Dysphasia	0.7%
885	Dermatomyositis	0.6%
886	Corneal Scar	0.6%
887	Muscular Dystrophy, Duchenne	0.6%
888	Retrograde amnesia	0.6%
889	Amnesia, Anterograde	0.6%
890	Dysarthria	0.6%
891	Rubinstein-Taybi Syndrome	0.6%
892	Mutism	0.6%
893	Selective Mutism	0.6%
894	Fragile X Syndrome	0.5%
895	Alexia, Pure	0.5%
896	Corneal Perforation	0.5%
897	Mucopolysaccharidosis II	0.4%

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