MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Osteochondrosis

(UMLS:C0029429)

Definition:: Any of a group of bone disorders involving one or more ossification centers (EPIPHYSES). It is characterized by degeneration or NECROSIS followed by revascularization and reossification. Osteochondrosis often occurs in children causing varying degrees of discomfort or pain. There are many eponymic types for specific affected areas, such as tarsal navicular (Kohler disease) and tibial tuberosity (Osgood-Schlatter disease).
UMLS ID:: C0029429
MeSH ID:: D055034

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.821

Synonym(s)

Osteochondrosis

Epiphyseal ischaemic necrosis, NOS

Epiphyseal ischemic necrosis

Epiphyseal ischemic necrosis, NOS

Epiphyseal necrosis, NOS

OSTEOCHONDROSIS

Osteochondrosis, NOS

osteochondroses

osteochondrosis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Levetiracetam	FAERS: 21	US FAERS
2	Ciprofloxacin	FAERS: 18 Canada Vigilance: 1	Canada Vigilance US FAERS
3	Isotretinoin	FAERS: 8	US FAERS
4	Alendronate	FAERS: 7	US FAERS
5	Finasteride	FAERS: 6	US FAERS
6	Zoledronic Acid	FAERS: 6	US FAERS
7	Methylphenidate	FAERS: 4 Canada Vigilance: 1	Canada Vigilance US FAERS
8	Prednisolone	FAERS: 4	US FAERS
9	Topiramate	FAERS: 4	US FAERS
10	Imatinib Mesylate	FAERS: 3	US FAERS
11	4-hydroxybutyric acid	FAERS: 2	US FAERS
12	Arthrotec	FAERS: 2	US FAERS
13	Ibandronic Acid	FAERS: 2	OFFSIDES US FAERS
14	Letrozole	FAERS: 2	US FAERS
15	Norgestrel	FAERS: 2	US FAERS
16	Solifenacin Succinate	FAERS: 2	US FAERS
17	Valproic Acid	FAERS: 2	US FAERS
18	Acitretin	FAERS: 1	US FAERS
19	Budesonide	FAERS: 1	US FAERS
20	Ciprofloxacin	FAERS: 1	US FAERS
21	Dimethyl Fumarate	FAERS: 1	US FAERS
22	Fingolimod Hydrochloride	FAERS: 1	US FAERS
23	Fluoxetine	FAERS: 1	US FAERS
24	Fractals	FAERS: 1	US FAERS
25	Glatiramer Acetate	FAERS: 1	US FAERS
26	Goserelin	FAERS: 1	US FAERS
27	Levofloxacin	FAERS: 1	US FAERS
28	Methylprednisolone	FAERS: 1	US FAERS
29	NuvaRing	FAERS: 1	US FAERS
30	Prednisone	FAERS: 1	US FAERS
31	Pregabalin	FAERS: 1	US FAERS
32	Qlaira	FAERS: 1	US FAERS
33	Quetiapine Fumarate	FAERS: 1	US FAERS
34	Ruxolitinib phosphate	FAERS: 1	US FAERS
35	Sertraline	FAERS: 1	US FAERS
36	Teriparatide	FAERS: 1	US FAERS
37	Thyroxine	FAERS: 1	US FAERS
38	betamethasone-17,21-dipropionate	FAERS: 1	US FAERS
39	carbidopa, levodopa drug combination	FAERS: 1	US FAERS
40	etravirine	FAERS: 1	US FAERS
41	macitentan	FAERS: 1	US FAERS
42	pazopanib	FAERS: 1	US FAERS
43	prednisolone phosphate	FAERS: 1	US FAERS
44	rofecoxib	FAERS: 1	US FAERS
45	Acetaminophen		OFFSIDES
46	Azathioprine		OFFSIDES
47	Bortezomib		OFFSIDES
48	Bupivacaine		OFFSIDES
49	Bupropion		OFFSIDES
50	Capecitabine		OFFSIDES
51	Chlordiazepoxide		OFFSIDES
52	Chlorhexidine		OFFSIDES
53	Clavulanic Acid		OFFSIDES
54	Clindamycin		OFFSIDES
55	Cortisone		OFFSIDES
56	Cyclopentolate		OFFSIDES
57	D-Galactosamine		OFFSIDES
58	Diazepam		OFFSIDES
59	Erlotinib Hydrochloride		OFFSIDES
60	Fluorouracil		OFFSIDES
61	Flurazepam		OFFSIDES
62	Gatifloxacin		OFFSIDES
63	Hydron;carbonate		OFFSIDES
64	Lanthanum carbonate hydrate		OFFSIDES
65	Levodopa		OFFSIDES
66	Meloxicam		OFFSIDES
67	Metronidazole		OFFSIDES
68	Mometasone Furoate		OFFSIDES
69	Mupirocin		OFFSIDES
70	Naproxen		OFFSIDES
71	OPC-67683		SIDER
72	Omeprazole		OFFSIDES
73	Pamidronate		OFFSIDES
74	Pantoprazole		OFFSIDES
75	Pioglitazone		OFFSIDES
76	Potassium Citrate		OFFSIDES
77	Pramipexole		OFFSIDES
78	Quinidine		OFFSIDES
79	Tamoxifen		OFFSIDES
80	Tilidine		OFFSIDES
81	Tobramycin		OFFSIDES
82	Tretinoin		OFFSIDES
83	Xipamide		OFFSIDES
84	chlorhexidine gluconate		OFFSIDES
85	exemestane		SIDER
86	sitaxsentan		SIDER
87	zopiclone		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Bone Diseases, Developmental	42.9%
2	Hyperostosis	42.9%
3	Osteitis	42.9%
4	Osteitis Deformans	42.9%
5	Spinal Diseases	42.9%
6	Osteoarthropathy, Secondary Hypertrophic	38.1%
7	Ainhum	31%
8	Dysostoses	31%
9	Spinal Stenosis	31%
10	Spondylosis	31%
11	Intervertebral Disc Degeneration	31%
12	Gigantism	30.5%
13	Spinal Neoplasms	30.5%
14	Spondylitis	30.5%
15	Bone Diseases, Endocrine	30%
16	Bone Diseases, Infectious	28.6%
17	Bone neoplasms	28.6%
18	Osteopenia	28.6%
19	Platybasia	28.2%
20	Osteochondritis	28.1%
21	Bone Resorption	27.9%
22	Aseptic Necrosis of Bone	27.9%
23	Chondrodysplasia Punctata	25.4%
24	Enchondromatosis	25.4%
25	Lordosis	25.4%
26	Osteosclerosis	25.4%
27	Spondylolysis	25.4%
28	kyphosis	25.4%
29	Kashin-Beck Disease	25.4%
30	Discitis	24.8%
31	Fasciitis	23.1%
32	Foot Deformities	23.1%
33	Arthropathy	23.1%
34	Melorheostosis	22.7%
35	Osteopetrosis	22.7%
36	Spondylolisthesis	22.7%
37	Pectus excavatum	22.4%
38	Multiple Epiphyseal Dysplasia	20.9%
39	Osteochondrodysplasias	20.9%
40	Osteomyelitis	20.5%
41	Osteoporosis	20.5%
42	Periostitis	20.5%
43	Bone Demineralization, Pathologic	20.5%
44	Post-Traumatic Osteoporosis	20.5%
45	Spondylarthropathies	20.4%
46	Alveolar Bone Loss	20.2%
47	Femur Head Necrosis	20.2%
48	Osteolysis	20.2%
49	Klippel-Feil Syndrome	19.7%
50	Synostosis	19.7%
51	Tuberculosis, Spinal	19.6%
52	Pectus carinatum	19.5%
53	Osteoarthritis, Spine	19.5%
54	Ankylosing spondylitis	19.2%
55	Contracture	19%
56	Fasciitis, Plantar	19%
57	Congenital Hypothyroidism	18.6%
58	Craniofacial Dysostosis	17.5%
59	Arthrogryposis	16.9%
60	Osteoporosis, Postmenopausal	16.7%
61	Dwarfism	16.4%
62	Jaw Diseases	15.8%
63	Arthritis, Psoriatic	15.3%
64	Acromegaly	15%
65	Joint Tuberculosis	15%
66	Tuberculosis, Osteoarticular	15%
67	Bone Tuberculosis	15%
68	Cartilage Diseases	15%
69	Foot Diseases	15%
70	Myopathy	15%
71	Rheumatism	15%
72	Chondromalacia	15%
73	Arthritis, Reactive	14.6%
74	Arthritis	14.3%
75	Bursitis	14.3%
76	Joint Instability	14.3%
77	Myofascial Pain Syndromes	14.3%
78	Rhabdomyolysis	14.3%
79	Synovitis	14.3%
80	Joint laxity	14.3%
81	Polyarthritis	14.3%
82	Frozen shoulder	14.3%
83	Patellofemoral Pain Syndrome	14.3%
84	Craniosynostosis	14%
85	Syndactyly	14%
86	Brachycephaly	14%
87	Fibromyalgia	14%
88	Polymyalgia Rheumatica	14%
89	Goldenhar Syndrome	14%
90	Metatarsalgia	13.9%
91	Hip Contracture	13.6%
92	Periarthritis	13.6%
93	Eosinophilic Granuloma	13.4%
94	Acrocephalosyndactylia	13.3%
95	Osteogenesis Imperfecta	12.8%
96	Mastoiditis	12.4%
97	Petrositis	12.4%
98	Osteoarthritis, Knee	12.4%
99	Poland Syndrome	12.3%
100	Mandibulofacial Dysostosis	12.2%
101	Ischemic contracture	12.2%
102	Rickets	12%
103	Rheumatic Fever	12%
104	Gout	11.2%
105	Temporomandibular Joint Disorders	11%
106	Talipes	10.9%
107	Antley-Bixler Syndrome Phenotype	10.7%
108	Bunion	10.3%
109	Fibrodysplasia Ossificans Progressiva	10.3%
110	Myoglobinuria	10.3%
111	Myositis Ossificans	10.3%
112	Tenosynovitis	10.3%
113	Sacroiliitis	10.3%
114	Temporomandibular Joint Dysfunction Syndrome	10.2%
115	Pseudohypoparathyroidism	10%
116	Osteomalacia	9.8%
117	Rheumatoid Arthritis	9.7%
118	Juvenile arthritis	9.7%
119	Compartment syndromes	9.5%
120	Maxillary Diseases	9.5%
121	Tendinitis	9.5%
122	Tendinopathy	9.5%
123	Hemarthrosis	9.3%
124	Myositis	9.3%
125	Tietze's Syndrome	9.3%
126	Limb Deformities, Congenital	9.3%
127	Isaacs syndrome	9.3%
128	Craniofacial Abnormalities	9.3%
129	Myotonic Disorders	9.3%
130	Congenital clubfoot	9.3%
131	Vertical Talus	9.3%
132	Palatal Neoplasms	9.2%
133	Rheumatoid Nodule	9.2%
134	Arthritis, Gouty	8.7%
135	Rubinstein-Taybi Syndrome	8.7%
136	Marfan Syndrome	7.7%
137	Basal Cell Nevus Syndrome	7.6%
138	Felty Syndrome	7.3%
139	Cockayne Syndrome	7.2%
140	Medial Tibial Stress Syndrome	7%
141	Arthritis, Infectious	7%
142	Mitochondrial Myopathies	6.9%
143	Muscle Cramp	6.8%
144	Eosinophilia-Myalgia Syndrome	6.8%
145	Gastroschisis	6.8%
146	Anterior Compartment Syndrome	6.8%
147	Enthesopathy	6.8%
148	Arthritis, Experimental	6.8%
149	Abdominal Compartment Syndrome	6.8%
150	Muscle Rigidity	6.8%
151	Muscle Spasticity	6.8%
152	Cogwheel Rigidity	6.8%
153	Nuchal Rigidity	6.8%
154	Amelia	6.7%
155	Arachnodactyly	6.7%
156	Ectromelia	6.7%
157	Hemimelia	6.7%
158	Phocomelia	6.7%
159	Sirenomelia	6.7%
160	Polymyositis	6.7%
161	Polydactyly	6.7%
162	Brachydactyly	6.7%
163	Plagiocephaly	6.7%
164	Lower Extremity Deformities, Congenital	6.7%
165	Upper Extremity Deformities, Congenital	6.7%
166	Nose Neoplasms	6.4%
167	Jaw Abnormalities	6.3%
168	Renal Osteodystrophy	6.1%
169	Renal rickets	6.1%
170	Rheumatoid Vasculitis	6.1%
171	Prognathism	6%
172	Chronic Fatigue Syndrome	5.8%
173	Nail-Patella Syndrome	5.6%
174	Giant Cell Epulis	5.5%
175	Muscle Weakness	5.5%
176	Musculoskeletal Pain	5.4%
177	Familial Periodic Paralysis	5.4%
178	Arthralgia	5.4%
179	Polyarthralgia	5.4%
180	Hip Dislocation	5.3%
181	Shoulder Dislocation	5.3%
182	Hip Dysplasia	5.3%
183	Sicca Syndrome	5.2%
184	Sjogren's Syndrome	5.2%
185	Muscular Dystrophy	5.1%
186	Orbital Myositis	5.1%
187	Dupuytren Contracture	5.1%
188	Pyomyositis	5%
189	Micrognathism	4.9%
190	Pierre Robin Syndrome	4.9%
191	Laryngomalacia	4.7%
192	Myotonic Dystrophy	4.6%
193	Myalgia	4.5%
194	Retrognathia	4.3%
195	Welander Distal Myopathy	4.1%
196	Maxillofacial Abnormalities	4.1%
197	Myotonia Congenita	4%
198	Bronchomalacia	4%
199	Tracheomalacia	4%
200	Microcephaly	4%
201	Macrocephaly	4%
202	Hypokalemic periodic paralysis	3.9%
203	Shoulder Pain	3.9%
204	Cleft Palate	3.4%
205	Dermatomyositis	3.4%
206	Muscular Dystrophy, Duchenne	3.3%
207	Familial Hypophosphatemic Rickets	3.3%
208	Mitochondrial Encephalomyopathies	3.3%
209	Porencephaly	3.3%
210	Noonan Syndrome	2.9%
211	Holoprosencephaly	2.5%
212	Radicular Cyst	2.4%
213	MELAS Syndrome	1.6%
214	Kearns-Sayre syndrome	1.5%

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