MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Temporomandibular Joint Dysfunction Syndrome

(UMLS:C0039496)

Definition:: A symptom complex consisting of pain, muscle tenderness, clicking in the joint, and limitation or alteration of mandibular movement. The symptoms are subjective and manifested primarily in the masticatory muscles rather than the temporomandibular joint itself. Etiologic factors are uncertain but include occlusal dysharmony and psychophysiologic factors.
UMLS ID:: C0039496
MeSH ID:: D013706

Classification 1:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.500.607.221.897.897|C05.550.905.905|C05.651.243.897.897|C05.651.550.905

Classification 2:

Name:

Stomatognathic Diseases
MeSH Tree Number(s):: C07.320.610.291.897.897|C07.678.949

Synonym(s)

Temporomandibular Joint Dysfunction Syndrome

Clicking jaw syndrome

Costen

Costen's Syndrome

Costen's complex

Costen's syndrome

Costen; complex

Mandibular dysfunction

Myofascial pain - dysfunction syndrome of TMJ

10.

PAIN-DYSFUNCTION SYNDROME

11.

Snapping jaw

12.

TEMPOROMANDIBULAR JOINT DYSFUNCTION

13.

TEMPOROMANDIBULAR JOINT PAIN-DYSFUNCTION SYNDROME

14.

TEMPOROMANDIBULAR JOINT SYNDROME

15.

TEMPOROMANDIBULAR JOINT-PAIN-DYSFUNCTION SYNDROME

16.

TMD

17.

TMJ SYNDROME

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Cocaine	18356857	CTD
2	Methamphetamine	18356857	CTD
3	N-Methyl-3,4-methylenedioxyamphetamine	18356857	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Arthrogryposis	33.3%
2	Contracture	32.4%
3	Ischemic contracture	25.3%
4	Fibromyalgia	24.3%
5	Polymyalgia Rheumatica	24.3%
6	Osteoarthropathy, Secondary Hypertrophic	23.1%
7	Prognathism	22.9%
8	Maxillary Diseases	21.8%
9	Rhabdomyolysis	20.7%
10	Metatarsalgia	20.4%
11	Hip Contracture	20.2%
12	Giant Cell Epulis	19.6%
13	Gout	19.4%
14	Jaw Abnormalities	19.4%
15	Compartment syndromes	18.3%
16	Tendinitis	18.3%
17	Tendinopathy	18.3%
18	Bone Diseases	18.2%
19	Fasciitis	18.2%
20	Foot Deformities	18.2%
21	Myositis	18.1%
22	Isaacs syndrome	18.1%
23	Myotonic Disorders	18.1%
24	Fasciitis, Plantar	18.1%
25	Jaw Diseases	17.8%
26	Periarthritis	17.8%
27	Retrognathia	17.5%
28	Pectus carinatum	17.2%
29	Temporomandibular Joint Disorders	17%
30	Osteoarthritis, Spine	17%
31	Medial Tibial Stress Syndrome	16.2%
32	Mitochondrial Myopathies	16.1%
33	Muscle Cramp	16.1%
34	Eosinophilia-Myalgia Syndrome	16.1%
35	Osteochondritis	16%
36	Cartilage Diseases	16%
37	Foot Diseases	16%
38	Rheumatism	16%
39	Chondromalacia	16%
40	Muscle Rigidity	16%
41	Muscle Spasticity	16%
42	Cogwheel Rigidity	16%
43	Nuchal Rigidity	16%
44	Arthritis	16%
45	Bursitis	16%
46	Joint Instability	16%
47	Synovitis	16%
48	Joint laxity	16%
49	Polyarthritis	16%
50	Frozen shoulder	16%
51	Patellofemoral Pain Syndrome	16%
52	Rheumatic Fever	15.9%
53	Chronic Fatigue Syndrome	14.9%
54	Temporomandibular Joint Dysfunction Syndrome	14.8%
55	Ankylosing spondylitis	14.7%
56	Muscle Weakness	14.5%
57	Musculoskeletal Pain	14.5%
58	Rheumatoid Arthritis	14.4%
59	Juvenile arthritis	14.4%
60	Familial Periodic Paralysis	14.4%
61	Hemarthrosis	14%
62	Cleft Palate	13.7%
63	Platybasia	13.4%
64	Arthropathy	13.3%
65	Arthritis, Psoriatic	13.2%
66	Arthritis, Gouty	13.2%
67	Palatal Neoplasms	13.1%
68	Myalgia	13%
69	Fibrodysplasia Ossificans Progressiva	13%
70	Myoglobinuria	13%
71	Myositis Ossificans	13%
72	Tenosynovitis	13%
73	Pectus excavatum	13%
74	Micrognathism	12.5%
75	Pierre Robin Syndrome	12.5%
76	Myofascial Pain Syndromes	12.1%
77	Osteoarthritis, Knee	11.9%
78	Myotonic Dystrophy	11.9%
79	Klippel-Feil Syndrome	11.4%
80	Synostosis	11.4%
81	Anterior Compartment Syndrome	11.4%
82	Enthesopathy	11.4%
83	Abdominal Compartment Syndrome	11.4%
84	Polymyositis	11.3%
85	Talipes	11.3%
86	Arthritis, Reactive	11.3%
87	Nail-Patella Syndrome	11.2%
88	Arthralgia	11.1%
89	Polyarthralgia	11.1%
90	Radicular Cyst	11%
91	Rheumatoid Nodule	10.6%
92	Acrocephalosyndactylia	10.3%
93	Craniosynostosis	10.3%
94	Syndactyly	10.3%
95	Brachycephaly	10.3%
96	Bone Diseases, Developmental	10.2%
97	Hyperostosis	10.2%
98	Osteitis	10.2%
99	Osteitis Deformans	10.2%
100	Osteochondrosis	10.2%
101	Spinal Diseases	10.2%
102	Muscular Dystrophy	10.1%
103	Orbital Myositis	10.1%
104	Sacroiliitis	10.1%
105	Dupuytren Contracture	10.1%
106	Pyomyositis	10.1%
107	Mouth Diseases	10%
108	Tooth Diseases	10%
109	Gigantism	9.9%
110	Spinal Neoplasms	9.9%
111	Spondylitis	9.9%
112	Sicca Syndrome	9.7%
113	Sjogren's Syndrome	9.7%
114	Felty Syndrome	9.5%
115	Spondylarthropathies	9.4%
116	Mouth Abnormalities	9.3%
117	Bone Diseases, Endocrine	9.2%
118	Myotonia Congenita	9.1%
119	Bone Diseases, Infectious	9%
120	Bone neoplasms	9%
121	Osteopenia	9%
122	Hypokalemic periodic paralysis	9%
123	Arthritis, Infectious	9%
124	Bone Resorption	9%
125	Tietze's Syndrome	9%
126	Limb Deformities, Congenital	9%
127	Craniofacial Abnormalities	9%
128	Aseptic Necrosis of Bone	9%
129	Pharyngeal Diseases	8.9%
130	Arthritis, Experimental	8.9%
131	Tooth Loss	8.7%
132	Rheumatoid Vasculitis	8.7%
133	Maxillofacial Abnormalities	8.6%
134	Craniofacial Dysostosis	8.4%
135	Congenital clubfoot	8.3%
136	Vertical Talus	8.3%
137	Alveolar Bone Loss	8.2%
138	Mitochondrial Encephalomyopathies	8.2%
139	Hip Dislocation	8%
140	Shoulder Dislocation	8%
141	Hip Dysplasia	8%
142	Gastroschisis	7.9%
143	Myopathy	7.9%
144	Facial Hemiatrophy	7.8%
145	Melkersson-Rosenthal Syndrome	7.8%
146	Basal Cell Nevus Syndrome	7.8%
147	Poland Syndrome	7.5%
148	Welander Distal Myopathy	7.1%
149	Shoulder Pain	7%
150	Bell Palsy	7%
151	Congenital Hypothyroidism	6.9%
152	Discitis	6.9%
153	Laryngomalacia	6.6%
154	Dermatomyositis	6.5%
155	Eosinophilic Granuloma	6.5%
156	Muscular Dystrophy, Duchenne	6.4%
157	Ainhum	6.4%
158	Bunion	6.4%
159	Dysostoses	6.4%
160	Spinal Stenosis	6.4%
161	Spondylosis	6.4%
162	Intervertebral Disc Degeneration	6.4%
163	Parotid Neoplasms	6.4%
164	Antley-Bixler Syndrome Phenotype	6.2%
165	Dental Enamel Hypoplasia	6.2%
166	Hypodontia	6.2%
167	Macrostomia	6.2%
168	Microstomia	6.2%
169	Salivary Gland Fistula	6.2%
170	Salivary Gland Neoplasms	6.2%
171	Tongue Neoplasms	6.2%
172	Tuberculosis, Spinal	6.2%
173	Bruxism	6%
174	Burning Mouth Syndrome	6%
175	Dental Leakage	6%
176	Hypercementosis	6%
177	Lip Diseases	6%
178	Malocclusion	6%
179	Microglossia	6%
180	Oral Submucous Fibrosis	6%
181	Periodontal Diseases	6%
182	Salivary Gland Diseases	6%
183	Stomatitis	6%
184	Tongue Diseases	6%
185	Tooth Crowding	6%
186	Tooth Discoloration	6%
187	Tooth Demineralization	6%
188	Oral Ulcer	6%
189	Tooth Ankylosis	6%
190	Rubinstein-Taybi Syndrome	5.8%
191	Multiple Epiphyseal Dysplasia	5.6%
192	Osteochondrodysplasias	5.6%
193	Osteomyelitis	5.6%
194	Osteoporosis	5.6%
195	Periostitis	5.6%
196	Bone Demineralization, Pathologic	5.6%
197	Post-Traumatic Osteoporosis	5.6%
198	Amelia	5.6%
199	Arachnodactyly	5.6%
200	Ectromelia	5.6%
201	Femur Head Necrosis	5.6%
202	Hemimelia	5.6%
203	Phocomelia	5.6%
204	Sirenomelia	5.6%
205	Polydactyly	5.6%
206	Brachydactyly	5.6%
207	Mandibulofacial Dysostosis	5.6%
208	Plagiocephaly	5.6%
209	Lower Extremity Deformities, Congenital	5.6%
210	Upper Extremity Deformities, Congenital	5.6%
211	Osteolysis	5.6%
212	Gingival Hemorrhage	5.5%
213	Tooth Injuries	5.3%
214	Gingival Recession	5.3%
215	Parotitis	5.3%
216	Gingival Atrophy	5.3%
217	Facial Nerve Diseases	5.3%
218	Tooth Resorption	5.3%
219	Granulomatosis, Orofacial	5.3%
220	Oral candidiasis	5.2%
221	Mouth Neoplasms	5.2%
222	Oral Fistula	5.2%
223	Toothache	5.2%
224	Lichen Planus, Oral	5.2%
225	Nasopharyngitis	5.1%
226	Dwarfism	5.1%
227	Goldenhar Syndrome	5.1%
228	Acromegaly	4.9%
229	Joint Tuberculosis	4.9%
230	Tuberculosis, Osteoarticular	4.9%
231	Bone Tuberculosis	4.9%
232	Pharyngitis	4.7%
233	Nasopharyngeal Neoplasms	4.7%
234	Facial paralysis	4.6%
235	Facial Paresis	4.6%
236	Hemifacial Spasm	4.6%
237	Chondrodysplasia Punctata	4.5%
238	Enchondromatosis	4.5%
239	Lordosis	4.5%
240	Osteosclerosis	4.5%
241	Spondylolysis	4.5%
242	kyphosis	4.5%
243	Kashin-Beck Disease	4.5%
244	Rickets	4.4%
245	Bronchomalacia	4.4%
246	Tracheomalacia	4.4%
247	Microcephaly	4.4%
248	Macrocephaly	4.4%
249	MELAS Syndrome	4.2%
250	Pharyngeal Neoplasms	4.2%
251	Pseudohypoparathyroidism	4%
252	Cheilitis	4%
253	Dental caries	4%
254	Dental Plaque	4%
255	Dental Pulp Calcification	4%
256	Drooling	4%
257	Gingival Diseases	4%
258	Glossitis	4%
259	Macroglossia	4%
260	Periodontitis	4%
261	Pulpitis	4%
262	Sialadenitis	4%
263	Sialometaplasia, Necrotizing	4%
264	Sialorrhea	4%
265	Aphthous Stomatitis	4%
266	Tooth Erosion	4%
267	Xerostomia	4%
268	Glossoptosis	4%
269	Peri-Implantitis	4%
270	Kearns-Sayre syndrome	4%
271	Osteoporosis, Postmenopausal	3.9%
272	Noonan Syndrome	3.7%
273	Tooth Avulsion	3.5%
274	Melorheostosis	3.5%
275	Osteopetrosis	3.5%
276	Spondylolisthesis	3.5%
277	Dental Pulp Necrosis	3.5%
278	Facial Neuralgia	3.5%
279	Osteogenesis Imperfecta	3.5%
280	Dental Fistula	3.5%
281	Oroantral Fistula	3.5%
282	Marfan Syndrome	3.5%
283	Mastoiditis	3.5%
284	Petrositis	3.5%
285	Behcet Syndrome	3.4%
286	Lemierre Syndrome	3.4%
287	Holoprosencephaly	3.4%
288	Nasopharyngeal carcinoma	3.3%
289	Vesicular Stomatitis	3.2%
290	Tonsillitis	3.1%
291	Sleep Bruxism	3.1%
292	Osteomalacia	3.1%
293	Porencephaly	3.1%
294	Gingivitis	3.1%
295	Glossitis, Benign Migratory	3.1%
296	Pericoronitis	3.1%
297	Aggressive Periodontitis	3.1%
298	Gingival Overgrowth	3.1%
299	Mobius Syndrome	2.8%
300	Herpes Zoster Oticus	2.8%
301	Leukoplakia, Oral	2.8%
302	Retropharyngeal Abscess	2.8%
303	Hypopharyngeal Neoplasms	2.8%
304	Hypopharyngeal Cancer	2.8%
305	Herpes Labialis	2.8%
306	Trigeminal Nerve Disorder	2.7%
307	Cockayne Syndrome	2.6%
308	Gingival Hyperplasia	2.6%
309	Gingival Hypertrophy	2.6%
310	Facial Nerve Injuries	2.5%
311	Nose Neoplasms	2.5%
312	Renal Osteodystrophy	2.4%
313	Renal rickets	2.4%
314	Toxic Epidermal Necrolysis	2.3%
315	Stevens-Johnson Syndrome	2.3%
316	Mumps	2.2%
317	Trigeminal Neuralgia	2.2%
318	Peritonsillar Abscess	2.1%
319	Tonsillar Neoplasms	2.1%
320	Ulcerative stomatitis	2%
321	Familial Hypophosphatemic Rickets	1.3%

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