MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Microstomia

(UMLS:C0026034)

Definition:: A congenital defect in which the mouth is unusually small. (Dorland, 27th ed)
UMLS ID:: C0026034
MeSH ID:: D008865

Classification 1:

Name:

Stomatognathic Diseases
MeSH Tree Number(s):: C07.465.525.520|C07.650.525.520

Classification 2:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.850.525.520

Synonym(s)

Microstomia

Narrow mouth

Small mouth

Small oral aperture

microstomia

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Valproic Acid	FAERS: 5		US FAERS
2	Levetiracetam	FAERS: 3		US FAERS
3	Metformin	FAERS: 1		US FAERS
4	Valproic Acid	FAERS: 1		US FAERS
5	Valproic Acid	FAERS: 1		US FAERS
6	Venlafaxine Hydrochloride	FAERS: 1		US FAERS
7	Alfentanil			OFFSIDES
8	Isotretinoin		3465061	CTD
9	Rocuronium			OFFSIDES
10	Thiopental			OFFSIDES
11	Tretinoin		9535508	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Macrostomia	51.6%
2	Cleft Palate	34.9%
3	Maxillofacial Abnormalities	24.3%
4	Facial Hemiatrophy	22.3%
5	Melkersson-Rosenthal Syndrome	22.3%
6	Dental Enamel Hypoplasia	20.9%
7	Hypodontia	20.9%
8	Burning Mouth Syndrome	20.2%
9	Lip Diseases	20.2%
10	Microglossia	20.2%
11	Oral Submucous Fibrosis	20.2%
12	Periodontal Diseases	20.2%
13	Salivary Gland Diseases	20.2%
14	Stomatitis	20.2%
15	Tongue Diseases	20.2%
16	Oral Ulcer	20.2%
17	Bell Palsy	19.1%
18	Tooth Loss	18.8%
19	Salivary Gland Fistula	17.6%
20	Salivary Gland Neoplasms	17.6%
21	Tongue Neoplasms	17.6%
22	Tooth Diseases	17.4%
23	Jaw Abnormalities	17.2%
24	Parotid Neoplasms	16.7%
25	Facial Nerve Diseases	16.3%
26	Granulomatosis, Orofacial	16.3%
27	Oral candidiasis	16.1%
28	Mouth Neoplasms	16.1%
29	Oral Fistula	16.1%
30	Lichen Planus, Oral	15.9%
31	Gingival Recession	15.7%
32	Parotitis	15.7%
33	Gingival Atrophy	15.7%
34	Gingival Hemorrhage	15.3%
35	Jaw Diseases	14.4%
36	Pharyngeal Diseases	14.4%
37	Mobius Syndrome	14.4%
38	Retrognathia	13.8%
39	Facial paralysis	13.3%
40	Facial Paresis	13.3%
41	Cheilitis	13.2%
42	Drooling	13.2%
43	Gingival Diseases	13.2%
44	Glossitis	13.2%
45	Macroglossia	13.2%
46	Periodontitis	13.2%
47	Sialadenitis	13.2%
48	Sialometaplasia, Necrotizing	13.2%
49	Sialorrhea	13.2%
50	Aphthous Stomatitis	13.2%
51	Xerostomia	13.2%
52	Glossoptosis	13.2%
53	Hemifacial Spasm	13.2%
54	Peri-Implantitis	13.2%
55	Abnormalities, Drug-Induced	12.6%
56	Situs Inversus	12.6%
57	Prognathism	12.5%
58	Micrognathism	12.4%
59	Pierre Robin Syndrome	12.4%
60	Beckwith-Wiedemann Syndrome	11.6%
61	Wolf-Hirschhorn Syndrome	11.6%
62	Giant Cell Epulis	11.5%
63	Temporomandibular Joint Disorders	11.1%
64	Holoprosencephaly	10.9%
65	Facial Neuralgia	10.6%
66	Dental Fistula	10.5%
67	Oroantral Fistula	10.5%
68	Eye Abnormalities	10.5%
69	Cardiovascular Abnormalities	10.5%
70	Skin Abnormalities	10.2%
71	Lymphatic Abnormalities	10.2%
72	Congenital Microtia	10.2%
73	Radicular Cyst	10.1%
74	Bruxism	10.1%
75	Dental Leakage	10.1%
76	Hypercementosis	10.1%
77	Malocclusion	10.1%
78	Tooth Crowding	10.1%
79	Tooth Discoloration	10.1%
80	Tooth Demineralization	10.1%
81	Tooth Ankylosis	10.1%
82	Aicardi's syndrome	10.1%
83	Smith-Magenis syndrome	10%
84	Congenital diaphragmatic hernia	10%
85	Behcet Syndrome	9.9%
86	Cri-du-Chat Syndrome	9.9%
87	Down Syndrome	9.9%
88	Trisomy 21	9.9%
89	Gingivitis	9.8%
90	Glossitis, Benign Migratory	9.8%
91	Pericoronitis	9.8%
92	Aggressive Periodontitis	9.8%
93	Gingival Overgrowth	9.8%
94	Vesicular Stomatitis	9.1%
95	Rubinstein-Taybi Syndrome	8.9%
96	Urogenital Abnormalities	8.8%
97	Palatal Neoplasms	8.7%
98	Ectodermal Dysplasia	8.7%
99	Aplasia Cutis Congenita	8.7%
100	Mouth Diseases	8.7%
101	Prader-Willi Syndrome	8.6%
102	Tooth Injuries	8.4%
103	Anencephaly	8.2%
104	Gingival Hyperplasia	8.2%
105	Gingival Hypertrophy	8.2%
106	Maxillary Diseases	8.2%
107	Tooth Resorption	8.2%
108	Toothache	8%
109	Alveolar Bone Loss	7.9%
110	Trigeminal Nerve Disorder	7.8%
111	Genetic Diseases, Inborn	7.8%
112	CHARGE Syndrome	7.8%
113	Herpes Zoster Oticus	7.6%
114	Leukoplakia, Oral	7.5%
115	Herpes Labialis	7.5%
116	Prune Belly Syndrome	7.4%
117	Twins, Conjoined	7.4%
118	Waardenburg Syndrome	7.4%
119	Dural Arteriovenous Fistula	7.1%
120	Dextrocardia	7.1%
121	Kartagener Syndrome	6.9%
122	Pharyngitis	6.9%
123	Mouth Abnormalities	6.8%
124	Nail-Patella Syndrome	6.8%
125	Marfan Syndrome	6.7%
126	Xeroderma	6.7%
127	Nasopharyngitis	6.6%
128	Dental caries	6.6%
129	Dental Plaque	6.6%
130	Dental Pulp Calcification	6.6%
131	Pulpitis	6.6%
132	Tooth Erosion	6.6%
133	Facial Nerve Injuries	6.6%
134	Mumps	6.5%
135	Trigeminal Neuralgia	6.5%
136	Fetal Diseases	6.3%
137	Temporomandibular Joint Dysfunction Syndrome	6.2%
138	Abnormalities, Radiation-Induced	6.2%
139	Anophthalmos	6%
140	Anus, Imperforate	6%
141	Hydranencephaly	6%
142	Microphthalmos	6%
143	Neural Tube Defects	6%
144	Tethered Cord Syndrome	6%
145	Iniencephaly	6%
146	Craniorachischisis	6%
147	Limb Deformities, Congenital	6%
148	Exencephaly	6%
149	Septo-Optic Dysplasia	6%
150	Craniofacial Abnormalities	6%
151	Cortical Dysplasia	6%
152	Malformations of Cortical Development	6%
153	Anorectal Malformations	6%
154	Bloom Syndrome	6%
155	Nasopharyngeal Neoplasms	5.9%
156	Pharyngeal Neoplasms	5.8%
157	Toxic Epidermal Necrolysis	5.8%
158	Stevens-Johnson Syndrome	5.8%
159	Scimitar Syndrome	5.6%
160	Polycystic Kidney Diseases	5.6%
161	Williams Syndrome	5.6%
162	Cockayne Syndrome	5.5%
163	Ulcerative stomatitis	5.5%
164	Tooth Avulsion	5.4%
165	Dental Pulp Necrosis	5.3%
166	Alstrom Syndrome	5.2%
167	Retinal Dysplasia	5.1%
168	Blepharophimosis	5.1%
169	Laryngostenosis	5.1%
170	Aniridia	5.1%
171	Esophageal Atresia	5%
172	Intestinal Atresia	5%
173	Horseshoe Kidney	5%
174	Pectus excavatum	5%
175	Klippel-Feil Syndrome	5%
176	Gastroschisis	5%
177	Synostosis	5%
178	Epidermolysis Bullosa	5%
179	Acrodermatitis	5%
180	Lymphangiectasis, Intestinal	5%
181	Gianotti-Crosti Syndrome	5%
182	Cystic Fibrosis	4.9%
183	Basal Cell Nevus Syndrome	4.9%
184	Craniosynostosis	4.9%
185	Syndactyly	4.9%
186	Brachycephaly	4.9%
187	Microcephaly	4.9%
188	Macrocephaly	4.9%
189	Fragile X Syndrome	4.9%
190	Smith-Lemli-Opitz Syndrome	4.7%
191	Ichthyosis, X-Linked	4.6%
192	Primary Ciliary Dyskinesia	4.5%
193	Acrocephalosyndactylia	4.4%
194	Noonan Syndrome	4.4%
195	Tonsillitis	4.4%
196	Sleep Bruxism	4.4%
197	Microstomia	4.4%
198	Lemierre Syndrome	4.4%
199	Arthrogryposis	4.4%
200	Choanal Atresia	4.4%
201	Tracheobronchomegaly	4.4%
202	Laryngocele	4.4%
203	Sicca Syndrome	4.4%
204	Sjogren's Syndrome	4.4%
205	Choledochal Cyst	4.3%
206	Hermaphroditism	4.3%
207	Disorders of Sex Development	4.3%
208	Cryptorchidism	4.3%
209	Hypospadias	4.3%
210	Central Nervous System Cysts	4.3%
211	Dandy-Walker Syndrome	4.3%
212	Meconium Aspiration Syndrome	4.3%
213	Turner Syndrome	4.2%
214	POEMS Syndrome	4.2%
215	Abdominal Cramps	4.2%
216	Amniotic Band Syndrome	4.2%
217	Asphyxia Neonatorum	4.2%
218	Infant, Premature, Diseases	4.2%
219	Infantile Colic	4.2%
220	Porencephaly	4.2%
221	Classical Lissencephalies and Subcortical Band Heterotopias	4.1%
222	Pseudoxanthoma Elasticum	4%
223	Amelia	3.9%
224	Arachnodactyly	3.9%
225	Ectopia Cordis	3.9%
226	Ectromelia	3.9%
227	Hemimelia	3.9%
228	Meningomyelocele	3.9%
229	Phocomelia	3.9%
230	Sirenomelia	3.9%
231	Spina Bifida	3.9%
232	Polydactyly	3.9%
233	Brachydactyly	3.9%
234	Plagiocephaly	3.9%
235	Lower Extremity Deformities, Congenital	3.9%
236	Upper Extremity Deformities, Congenital	3.9%
237	Single umbilical artery	3.9%
238	Nasopharyngeal carcinoma	3.9%
239	Laryngomalacia	3.8%
240	Pectus carinatum	3.8%
241	Retropharyngeal Abscess	3.8%
242	Hypopharyngeal Neoplasms	3.8%
243	Hypopharyngeal Cancer	3.8%
244	Bladder Exstrophy	3.7%
245	Epispadias	3.7%
246	Multicystic Dysplastic Kidney	3.7%
247	Polycystic Kidney, Autosomal Dominant	3.7%
248	Sjogren-Larsson Syndrome	3.7%
249	Xeroderma Pigmentosum	3.6%
250	Poland Syndrome	3.6%
251	Neoplastic Syndromes, Hereditary	3.5%
252	Kallmann Syndrome	3.5%
253	Klinefelter Syndrome	3.4%
254	Anemia, Neonatal	3.4%
255	Multiple Epiphyseal Dysplasia	3.4%
256	Osteochondrodysplasias	3.4%
257	Pelger-Huet Anomaly	3.4%
258	Persistent Fetal Circulation Syndrome	3.4%
259	Werner Syndrome	3.4%
260	Myasthenic Syndromes, Congenital	3.4%
261	Umbilical hernia	3.3%
262	Aortic coarctation	3.3%
263	Cor Triatriatum	3.3%
264	Coronary Vessel Anomalies	3.3%
265	Patent ductus arteriosus	3.3%
266	Ebstein Anomaly	3.3%
267	Heart Septal Defects	3.3%
268	Meningocele	3.3%
269	Tetralogy of Fallot	3.3%
270	Transposition of Great Vessels	3.3%
271	Hypoplastic Left Heart Syndrome	3.3%
272	May-Thurner Syndrome	3.3%
273	Encephalocele	3.3%
274	Craniofacial Dysostosis	3.3%
275	Zellweger Syndrome	3.3%
276	Wolff-Parkinson-White Syndrome	3.3%
277	Charcot-Marie-Tooth Disease	3.3%
278	Antley-Bixler Syndrome Phenotype	3.3%
279	Hyperkeratosis, Epidermolytic	3.1%
280	Tuberous Sclerosis	3%
281	Dermal Sinus	2.9%
282	Spina Bifida Cystica	2.9%
283	Spina Bifida Occulta	2.9%
284	Lissencephaly	2.9%
285	Polymicrogyria	2.9%
286	Pachygyria	2.9%
287	Schizencephaly	2.9%
288	Periventricular Nodular Heterotopia	2.9%
289	Dwarfism	2.9%
290	Neonatal Abstinence Syndrome	2.9%
291	Long QT Syndrome	2.8%
292	Platybasia	2.8%
293	Tricuspid Atresia	2.8%
294	Arrhythmogenic Right Ventricular Dysplasia	2.8%
295	Anemia, Sickle Cell	2.8%
296	Thalassemia	2.8%
297	Gonadal Dysgenesis	2.8%
298	Bronchomalacia	2.8%
299	Adrenogenital Syndrome	2.8%
300	Tracheomalacia	2.8%
301	Ovotesticular Disorders of Sex Development	2.8%
302	Muscular Dystrophy, Duchenne	2.8%
303	Fetal Growth Retardation	2.8%
304	Peritonsillar Abscess	2.8%
305	Tonsillar Neoplasms	2.8%
306	Muscular Dystrophy	2.8%
307	Osteogenesis Imperfecta	2.8%
308	Refsum Disease	2.8%
309	Fetal Hypoxia	2.8%
310	Congenital nystagmus	2.8%
311	Fetal Alcohol Spectrum Disorders	2.8%
312	Toxoplasmosis, Congenital	2.8%
313	Syphilis, Congenital	2.7%
314	Albinism	2.6%
315	Hyperandrogenism	2.6%
316	Familial Mediterranean Fever	2.5%
317	Aortopulmonary Septal Defect	2.4%
318	Double Outlet Right Ventricle	2.4%
319	Endocardial Cushion Defects	2.4%
320	Myocardial bridging	2.4%
321	Aorticopulmonary Septal Defect	2.4%
322	Autoimmune Lymphoproliferative Syndrome	2.4%
323	Congenital Hyperinsulinism	2.4%
324	Chorioamnionitis	2.4%
325	Angioedemas, Hereditary	2.4%
326	Wiskott-Aldrich Syndrome	2.2%
327	Rett Syndrome	2.2%
328	Mandibulofacial Dysostosis	2.1%
329	Romano-Ward Syndrome	2.1%
330	Mucopolysaccharidosis II	2%
331	Truncus Arteriosus, Persistent	2%
332	Goldenhar Syndrome	2%
333	Paralysis, Obstetric	2%
334	Retinopathy of Prematurity	2%
335	Menkes Kinky Hair Syndrome	2%
336	Amino Acid Metabolism, Inborn Errors	2%
337	Carbohydrate Metabolism, Inborn Errors	2%
338	Metal Metabolism, Inborn Errors	2%
339	Progeria	2%
340	Lysosomal Storage Diseases	2%
341	Cytochrome-c Oxidase Deficiency	2%
342	Peroxisomal Disorders	2%
343	Bronchopulmonary Dysplasia	2%
344	Myotonic Dystrophy	2%
345	Sickle Cell Trait	1.9%
346	Neuronal Ceroid-Lipofuscinoses	1.8%
347	Ophthalmia Neonatorum	1.8%
348	Talipes	1.8%
349	Respiratory Distress Syndrome, Newborn	1.7%
350	Cutis Laxa	1.7%
351	Ataxia Telangiectasia	1.7%
352	Retinitis Pigmentosa	1.7%
353	Pigmentary retinopathy	1.7%
354	Porokeratosis	1.7%
355	Keratoderma, Palmoplantar	1.7%
356	Chronic granulomatous disease	1.6%
357	Hepatolenticular Degeneration	1.6%
358	Welander Distal Myopathy	1.6%
359	Arteriovenous fistula	1.6%
360	Amyloid Neuropathies, Familial	1.6%
361	Adrenoleukodystrophy	1.6%
362	Congenital clubfoot	1.6%
363	Vertical Talus	1.6%
364	Hydrops Fetalis	1.5%
365	Acute Chest Syndrome	1.5%
366	Duane Retraction Syndrome	1.4%
367	Galactosemias	1.4%
368	Urea Cycle Disorders, Inborn	1.4%
369	Tyrosinemias	1.4%
370	Fabry Disease	1.4%
371	Porphyrias, Hepatic	1.4%
372	Peutz-Jeghers Syndrome	1.4%
373	Myotonia Congenita	1.4%
374	Thrombasthenia	1.4%
375	Antithrombin III Deficiency	1.4%
376	Protein C Deficiency	1.4%
377	Brain Diseases, Metabolic, Inborn	1.4%
378	Afibrinogenemia	1.4%
379	Dystonia Musculorum Deformans	1.4%
380	Factor VII Deficiency	1.4%
381	Factor X Deficiency	1.4%
382	Factor XII Deficiency	1.4%
383	Hemophilia A	1.4%
384	Leukomalacia, Periventricular	1.4%
385	Activated Protein C Resistance	1.4%
386	Factor II deficiency	1.4%
387	Factor VIII Deficiency	1.4%
388	Factor V deficiency	1.4%
389	Factor XI Deficiency	1.4%
390	Hypoprothrombinemias	1.4%
391	Fanconi Anemia	1.4%
392	Nesidioblastosis	1.4%
393	Lafora Disease	1.4%
394	Unverricht-Lundborg Syndrome	1.4%
395	Anemia, Diamond-Blackfan	1.4%
396	Denys-Drash Syndrome	1.4%
397	Canavan Disease	1.3%
398	Alexander Disease	1.3%
399	Glycogen storage disease type II	1.3%
400	Alkaptonuria	1.3%
401	Glycogen Storage Disease	1.3%
402	Hypophosphatasia	1.3%
403	Propionic acidemia	1.3%
404	Dihydropyrimidine Dehydrogenase Deficiency	1.3%
405	Cystinosis	1.3%
406	Optic Atrophy, Hereditary, Leber	1.3%
407	Hyperphosphaturia	1.3%
408	Multiple Endocrine Neoplasia	1.3%
409	Congenital Hypothyroidism	1.3%
410	Dermatitis, Atopic	1.2%
411	Mucopolysaccharidosis III	1.2%
412	Homocystinuria	1.1%
413	Leigh Disease	1.1%
414	Kernicterus	1.1%
415	Hyaline Membrane Disease	1.1%
416	Hypolipoproteinemias	1.1%
417	Papillon-Lefevre Disease	1.1%
418	Hyperlipidemia, Familial Combined	1.1%
419	Hyperlipoproteinemia Type III	1.1%
420	Gaucher Disease	1%
421	Huntington Disease	1%
422	Glycogen Storage Disease Type I	1%
423	Glycogen Storage Disease Type V	1%
424	Carbamoyl-Phosphate Synthase I Deficiency Disease	1%
425	Familial Periodic Paralysis	0.9%
426	Lactose Intolerance	0.9%
427	Variegate Porphyria	0.9%
428	Acute intermittent porphyria	0.9%
429	Porphyria Cutanea Tarda	0.9%
430	Hyperhomocysteinemia	0.9%
431	Renal Aminoacidurias	0.9%
432	Fanconi Syndrome	0.9%
433	Pseudohypoaldosteronism	0.9%
434	Liddle Syndrome	0.9%
435	Hyperlipoproteinemia Type IV	0.9%
436	Hyperlipoproteinemia Type V	0.9%
437	Nephroblastoma	0.9%
438	Tay-Sachs Disease	0.8%
439	Gout	0.8%
440	Niemann-Pick Disease, Type C	0.8%
441	Multiple Endocrine Neoplasia Type 1	0.8%
442	Pseudohypoparathyroidism	0.8%
443	Friedreich Ataxia	0.8%
444	Adenomatous Polyposis Coli	0.8%
445	Renal tubular acidosis	0.8%
446	Hypoalphalipoproteinemias	0.8%
447	Hypokalemic periodic paralysis	0.7%
448	Cystinuria	0.7%
449	Glycosuria, Renal	0.6%
450	Familial Hypophosphatemic Rickets	0.6%
451	Arthritis, Gouty	0.6%
452	MELAS Syndrome	0.5%

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