MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Spondylarthropathies

(UMLS:C0949691)

Definition:: Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.
UMLS ID:: C0949691
MeSH ID:: D025242

Classification:

Name:

Musculoskeletal Diseases
MeSH Tree Number(s):: C05.116.900.853.625.800|C05.550.114.865.800

Synonym(s)

Spondylarthropathies

Disorder of joint of spine

Spondarthropathy

Spondylarthrosis

Spondylarthrosis, NOS

Spondyloarthropathies

Spondyloarthropathy

spinal joint disease

spondylarthropathies

10.

spondylarthropathy

11.

spondylarthrosis

12.

spondyloarthropathies

13.

spondyloarthropathy

14.

spondyloarthrosis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Methotrexate	19346146	CTD
2	Sulfasalazine	8104747 9805178	CTD
3	Warfarin	8875729	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Osteoarthritis, Spine	45.7%
2	Osteoarthropathy, Secondary Hypertrophic	32.1%
3	Periarthritis	28.6%
4	Sacroiliitis	25.4%
5	Contracture	24.5%
6	Spinal Stenosis	22.2%
7	Spondylosis	22.2%
8	Intervertebral Disc Degeneration	22.2%
9	Arthrogryposis	21.8%
10	Rheumatic Fever	21.8%
11	Bursitis	21.5%
12	Joint Instability	21.5%
13	Synovitis	21.5%
14	Joint laxity	21.5%
15	Frozen shoulder	21.5%
16	Patellofemoral Pain Syndrome	21.5%
17	Gout	20.9%
18	Bone Diseases, Developmental	20.4%
19	Hyperostosis	20.4%
20	Osteitis	20.4%
21	Osteitis Deformans	20.4%
22	Osteochondrosis	20.4%
23	Spinal Neoplasms	20.3%
24	Fasciitis	20.2%
25	Foot Deformities	20.2%
26	Discitis	19.9%
27	Platybasia	19.9%
28	Arthritis, Infectious	19.5%
29	Metatarsalgia	19.4%
30	Arthritis, Experimental	19.2%
31	Osteochondritis	18.9%
32	Rheumatoid Arthritis	18.5%
33	Juvenile arthritis	18.5%
34	Osteoarthritis, Knee	17%
35	Tuberculosis, Spinal	16.5%
36	Hemarthrosis	16.2%
37	Bone Diseases, Endocrine	16.2%
38	Fasciitis, Plantar	16%
39	Jaw Diseases	15.8%
40	Bone Diseases, Infectious	15.6%
41	Bone neoplasms	15.6%
42	Osteopenia	15.6%
43	Bone Resorption	15.4%
44	Aseptic Necrosis of Bone	15.4%
45	Cartilage Diseases	15.3%
46	Foot Diseases	15.3%
47	Myopathy	15.3%
48	Rheumatism	15.3%
49	Chondromalacia	15.3%
50	Pectus carinatum	14.1%
51	Hip Contracture	13.9%
52	Temporomandibular Joint Disorders	13.8%
53	Arthritis, Psoriatic	13.8%
54	Gigantism	13.8%
55	Rheumatoid Nodule	13.6%
56	Lordosis	13.4%
57	Spondylolysis	13.4%
58	kyphosis	13.4%
59	Pectus excavatum	13.3%
60	Arthritis, Gouty	13.1%
61	Fibromyalgia	12.8%
62	Polymyalgia Rheumatica	12.8%
63	Ischemic contracture	12.3%
64	Felty Syndrome	11.4%
65	Ainhum	11.4%
66	Dysostoses	11.4%
67	Nail-Patella Syndrome	10.9%
68	Arthralgia	10.6%
69	Polyarthralgia	10.6%
70	Klippel-Feil Syndrome	10.6%
71	Synostosis	10.6%
72	Myofascial Pain Syndromes	10.5%
73	Rhabdomyolysis	10.5%
74	Bone Diseases	10.4%
75	Arthropathy	9.8%
76	Rheumatoid Vasculitis	9.7%
77	Arthritis, Reactive	9.5%
78	Temporomandibular Joint Dysfunction Syndrome	9.4%
79	Spondylolisthesis	9%
80	Spondylitis	8.9%
81	Ankylosing spondylitis	8.8%
82	Multiple Epiphyseal Dysplasia	8.7%
83	Osteochondrodysplasias	8.7%
84	Eosinophilic Granuloma	8.7%
85	Osteomyelitis	8.6%
86	Osteoporosis	8.6%
87	Periostitis	8.6%
88	Bone Demineralization, Pathologic	8.6%
89	Post-Traumatic Osteoporosis	8.6%
90	Sicca Syndrome	8.6%
91	Sjogren's Syndrome	8.6%
92	Alveolar Bone Loss	8.5%
93	Femur Head Necrosis	8.5%
94	Osteolysis	8.5%
95	Congenital Hypothyroidism	8%
96	Compartment syndromes	8%
97	Maxillary Diseases	8%
98	Tendinitis	8%
99	Tendinopathy	8%
100	Myositis	7.9%
101	Tietze's Syndrome	7.9%
102	Limb Deformities, Congenital	7.9%
103	Isaacs syndrome	7.9%
104	Craniofacial Abnormalities	7.9%
105	Myotonic Disorders	7.9%
106	Craniofacial Dysostosis	7.8%
107	Hip Dislocation	7.7%
108	Shoulder Dislocation	7.7%
109	Hip Dysplasia	7.7%
110	Talipes	7.3%
111	Dwarfism	7.3%
112	Craniosynostosis	7.2%
113	Syndactyly	7.2%
114	Brachycephaly	7.2%
115	Chondrodysplasia Punctata	7%
116	Enchondromatosis	7%
117	Osteosclerosis	7%
118	Kashin-Beck Disease	7%
119	Acromegaly	6.8%
120	Joint Tuberculosis	6.8%
121	Tuberculosis, Osteoarticular	6.8%
122	Bone Tuberculosis	6.8%
123	Medial Tibial Stress Syndrome	6.4%
124	Mitochondrial Myopathies	6.3%
125	Muscle Cramp	6.3%
126	Eosinophilia-Myalgia Syndrome	6.3%
127	Gastroschisis	6.3%
128	Muscle Rigidity	6.2%
129	Muscle Spasticity	6.2%
130	Cogwheel Rigidity	6.2%
131	Nuchal Rigidity	6.2%
132	Shoulder Pain	6.1%
133	Bunion	5.9%
134	Fibrodysplasia Ossificans Progressiva	5.9%
135	Myoglobinuria	5.9%
136	Myositis Ossificans	5.9%
137	Tenosynovitis	5.9%
138	Rickets	5.7%
139	Acrocephalosyndactylia	5.6%
140	Spinal Diseases	5.5%
141	Chronic Fatigue Syndrome	5.5%
142	Jaw Abnormalities	5.4%
143	Giant Cell Epulis	5.3%
144	Muscle Weakness	5.3%
145	Musculoskeletal Pain	5.2%
146	Osteoporosis, Postmenopausal	5.2%
147	Familial Periodic Paralysis	5.2%
148	Arthritis	5%
149	Polyarthritis	5%
150	Pseudohypoparathyroidism	4.9%
151	Poland Syndrome	4.8%
152	Melorheostosis	4.8%
153	Osteopetrosis	4.8%
154	Congenital clubfoot	4.8%
155	Vertical Talus	4.8%
156	Antley-Bixler Syndrome Phenotype	4.6%
157	Laryngomalacia	4.6%
158	Anterior Compartment Syndrome	4.5%
159	Enthesopathy	4.5%
160	Abdominal Compartment Syndrome	4.5%
161	Amelia	4.5%
162	Arachnodactyly	4.5%
163	Ectromelia	4.5%
164	Hemimelia	4.5%
165	Phocomelia	4.5%
166	Sirenomelia	4.5%
167	Polymyositis	4.5%
168	Polydactyly	4.5%
169	Brachydactyly	4.5%
170	Plagiocephaly	4.5%
171	Lower Extremity Deformities, Congenital	4.5%
172	Upper Extremity Deformities, Congenital	4.5%
173	Myalgia	4.4%
174	Prognathism	4.4%
175	Rubinstein-Taybi Syndrome	4.4%
176	Osteogenesis Imperfecta	4.3%
177	Mandibulofacial Dysostosis	4.3%
178	Mastoiditis	4.2%
179	Petrositis	4.2%
180	Basal Cell Nevus Syndrome	4.2%
181	Palatal Neoplasms	4.1%
182	Marfan Syndrome	3.9%
183	Goldenhar Syndrome	3.8%
184	Muscular Dystrophy	3.6%
185	Orbital Myositis	3.6%
186	Dupuytren Contracture	3.6%
187	Pyomyositis	3.6%
188	Osteomalacia	3.5%
189	Myotonic Dystrophy	3.3%
190	Micrognathism	3.2%
191	Pierre Robin Syndrome	3.2%
192	Maxillofacial Abnormalities	3%
193	Myotonia Congenita	3%
194	Bronchomalacia	3%
195	Tracheomalacia	3%
196	Microcephaly	3%
197	Macrocephaly	3%
198	Hypokalemic periodic paralysis	2.9%
199	Retrognathia	2.9%
200	Cockayne Syndrome	2.7%
201	Mitochondrial Encephalomyopathies	2.6%
202	Nose Neoplasms	2.4%
203	Spondylarthropathies	2.4%
204	Cleft Palate	2.4%
205	Renal Osteodystrophy	2.3%
206	Renal rickets	2.3%
207	Noonan Syndrome	2.3%
208	Welander Distal Myopathy	2.3%
209	Holoprosencephaly	2%
210	Dermatomyositis	1.9%
211	Muscular Dystrophy, Duchenne	1.9%
212	Porencephaly	1.9%
213	Radicular Cyst	1.1%
214	Familial Hypophosphatemic Rickets	1%
215	MELAS Syndrome	1%
216	Kearns-Sayre syndrome	0.9%

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