MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cystic Fibrosis

(UMLS:C0010674)

Definition:: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
UMLS ID:: C0010674
MeSH ID:: D003550

Classification 1:

Name:

Digestive System Diseases
MeSH Tree Number(s):: C06.689.202

Classification 2:

Name:

Respiratory Tract Diseases
MeSH Tree Number(s):: C08.381.187

Classification 3:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.320.190|C16.614.213

Synonym(s)

Cystic Fibrosis

CF (cystic fibrosis)

CF - Cystic fibrosis

CYSTIC FIBROSIS

Cystic fibrosis

Cystic fibrosis, unspecified

Disease;fibrocystic

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	2-[(E)-[1-(2-Amino-1,3-thiazol-4-yl)-2-[[(2S,3S)-2-methyl-4-oxo-1-sulfoazetidin-3-yl]amino]-2-oxoethylidene]amino]oxy-2-methylpropanoic acid;(2S)-2,6-diaminohexanoic acid	FAERS: 897 Canada Vigilance: 21		Canada Vigilance US FAERS
2	Tobramycin	FAERS: 113	19747007	CTD OFFSIDES US FAERS
3	lumacaftor, ivacaftor drug combination	FAERS: 83		US FAERS
4	Aztreonam	FAERS: 33 Canada Vigilance: 2	19747007	CTD Canada Vigilance US FAERS
5	ivacaftor	FAERS: 20	View details 21083385 21303308 22047557 25946147	CTD US FAERS
6	Ondansetron	FAERS: 5		US FAERS
7	4-hydroxybutyric acid	FAERS: 4		US FAERS
8	Budesonide	FAERS: 4		US FAERS
9	Clozapine	FAERS: 4		US FAERS
10	Sildenafil Citrate	FAERS: 4	19747007	CTD US FAERS
11	Teriparatide	FAERS: 4		US FAERS
12	ambrisentan	FAERS: 4		US FAERS
13	dolutegravir	FAERS: 4		US FAERS
14	Albuterol	FAERS: 3		US FAERS
15	NuvaRing	FAERS: 3		US FAERS
16	Tacrolimus	FAERS: 3		US FAERS
17	Tiotropium Bromide	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
18	Zoledronic Acid	FAERS: 3 Canada Vigilance: 1		Canada Vigilance US FAERS
19	etonogestrel	FAERS: 3		OFFSIDES US FAERS
20	Bosentan	FAERS: 2		US FAERS
21	Fluticasone	FAERS: 2		US FAERS
22	Methotrexate	FAERS: 2	2388211 19747007	CTD US FAERS
23	Mycophenolic Acid	FAERS: 2		US FAERS
24	Sitagliptin Phosphate	FAERS: 2		US FAERS
25	4-Aminopyridine	FAERS: 1		US FAERS
26	Alendronate	FAERS: 1		US FAERS
27	Azithromycin	FAERS: 1		US FAERS
28	Cefepime	FAERS: 1		US FAERS
29	Clobazam	FAERS: 1		US FAERS
30	Cysteamine	FAERS: 1		US FAERS
31	Fluticasone-Salmeterol Drug Combination	FAERS: 1		US FAERS
32	Insulin Glargine	FAERS: 1		US FAERS
33	Letrozole	FAERS: 1		US FAERS
34	Lorazepam	FAERS: 1		US FAERS
35	Meropenem	FAERS: 1		US FAERS
36	Methylphenidate	FAERS: 1		US FAERS
37	Methylphenidate	FAERS: 1		US FAERS
38	Morphine	FAERS: 1		US FAERS
39	Mycophenolic Acid	FAERS: 1		US FAERS
40	Norgestrel	FAERS: 1		US FAERS
41	Oxcarbazepine	FAERS: 1		US FAERS
42	Phenytoin	FAERS: 1		US FAERS
43	Sertraline	FAERS: 1		US FAERS
44	Tadalafil	FAERS: 1		US FAERS
45	Tapentadol	FAERS: 1		US FAERS
46	Topiramate	FAERS: 1		US FAERS
47	Valsartan	FAERS: 1		US FAERS
48	apremilast	FAERS: 1		US FAERS
49	perampanel	FAERS: 1		US FAERS
50	pirfenidone	FAERS: 1		US FAERS
51	treprostinil	FAERS: 1		US FAERS
52	Acetylcysteine		19747007	CTD
53	Albuterol	Canada Vigilance: 2		Canada Vigilance
54	Amikacin		18613859 19747007	CTD
55	Beclomethasone			OFFSIDES
56	Beclomethasone			OFFSIDES
57	Calcium Carbonate			OFFSIDES
58	Ciprofloxacin		3555062 19747007	CTD
59	Colistin		19747007	CTD
60	Deamino Arginine Vasopressin		3147111	CTD
61	Docosahexaenoic Acids		19747007	CTD
62	Fosfomycin		19747007	CTD
63	Glutathione		19747007	CTD
64	Hydroxychloroquine		19747007	CTD
65	Ibuprofen		9424574	CTD
66	Lansoprazole		9641739	CTD
67	Nevirapine			OFFSIDES
68	Nifedipine		6476600	CTD
69	Nystatin			OFFSIDES
70	Ofloxacin		19747007	CTD
71	Pioglitazone		19747007	CTD
72	Piperacillin		12366773	CTD
73	Simvastatin		19747007	CTD
74	Ursodeoxycholic Acid		2391071	CTD
75	denufosol tetrasodium		19747007	CTD
76	dimethyl sulfide		16455833	CTD
77	lamivudine, zidovudine drug combination			OFFSIDES
78	miglustat		19299496	CTD
79	montelukast	Canada Vigilance: 1		Canada Vigilance
80	pentane		16455833	CTD
81	zafirlukast		15463842	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Persistent Fetal Circulation Syndrome	29.4%
2	Meconium Aspiration Syndrome	28.9%
3	Respiratory Distress Syndrome, Newborn	28.3%
4	Ichthyosis, X-Linked	26.4%
5	Fragile X Syndrome	26.2%
6	Aicardi's syndrome	25.6%
7	Acute Chest Syndrome	24.6%
8	Congenital Hyperinsulinism	24.3%
9	Kartagener Syndrome	24.2%
10	Beckwith-Wiedemann Syndrome	23.8%
11	Wolf-Hirschhorn Syndrome	23.8%
12	Abdominal Cramps	22.9%
13	Amniotic Band Syndrome	22.9%
14	Asphyxia Neonatorum	22.9%
15	Infant, Premature, Diseases	22.9%
16	Infantile Colic	22.9%
17	Bronchopulmonary Dysplasia	22.5%
18	CHARGE Syndrome	22%
19	Hyaline Membrane Disease	21.7%
20	Alstrom Syndrome	21.6%
21	Albinism	21.1%
22	Holoprosencephaly	21%
23	Mucopolysaccharidosis II	21%
24	Smith-Magenis syndrome	20.9%
25	Primary Ciliary Dyskinesia	20.8%
26	Cri-du-Chat Syndrome	20.6%
27	Down Syndrome	20.6%
28	Trisomy 21	20.6%
29	Anemia, Sickle Cell	20.6%
30	Thalassemia	20.6%
31	Cockayne Syndrome	20.5%
32	Muscular Dystrophy, Duchenne	20.5%
33	Sjogren-Larsson Syndrome	19.5%
34	Neoplastic Syndromes, Hereditary	19.5%
35	Rett Syndrome	19.5%
36	Nail-Patella Syndrome	19.3%
37	Xeroderma	19.1%
38	Mobius Syndrome	19.1%
39	Idiopathic Pulmonary Fibrosis	19.1%
40	Pneumonia	19%
41	Lobar Pneumonia	19%
42	Respiratory Distress Syndrome, Adult	19%
43	Hepatopulmonary Syndrome	19%
44	Pneumonitis	19%
45	Menkes Kinky Hair Syndrome	19%
46	Anemia, Neonatal	18.8%
47	Multiple Epiphyseal Dysplasia	18.8%
48	Osteochondrodysplasias	18.8%
49	Pelger-Huet Anomaly	18.8%
50	Werner Syndrome	18.8%
51	Myasthenic Syndromes, Congenital	18.8%
52	Scimitar Syndrome	18.8%
53	Umbilical hernia	18.7%
54	Pneumoconiosis	18.4%
55	Ectodermal Dysplasia	18.3%
56	Aplasia Cutis Congenita	18.3%
57	Prader-Willi Syndrome	18.2%
58	Bronchitis, Chronic	17.9%
59	Nesidioblastosis	17.9%
60	Rubinstein-Taybi Syndrome	17.8%
61	Deformity	17.6%
62	Smith-Lemli-Opitz Syndrome	17.5%
63	Bronchitis	17.2%
64	Atelectasis	17.1%
65	Pulmonary Hypertension	17.1%
66	Pancreatic Insufficiency	17.1%
67	Pancreatitis	17.1%
68	Pulmonary Alveolar Proteinosis	17.1%
69	Pulmonary Edema	17.1%
70	Pulmonary Fibrosis	17.1%
71	Hamman-Rich syndrome	17.1%
72	Lung Diseases, Interstitial	17.1%
73	Lung Diseases, Obstructive	17.1%
74	Marfan Syndrome	16.9%
75	Familial Mediterranean Fever	16.9%
76	Sickle Cell Trait	16.9%
77	Dwarfism	16.5%
78	Hyperkeratosis, Epidermolytic	16.4%
79	Lung Diseases, Fungal	16.3%
80	Neonatal Abstinence Syndrome	16.3%
81	Wiskott-Aldrich Syndrome	16.3%
82	Hepatolenticular Degeneration	16.1%
83	Lung Abscess	16.1%
84	Lung Neoplasms	16.1%
85	Pancreatic Fistula	16.1%
86	Adrenoleukodystrophy	16.1%
87	Tuberculosis, Pulmonary	16%
88	Bronchopneumonia	16%
89	Tracheobronchomegaly	15.9%
90	Muscular Dystrophy	15.9%
91	Osteogenesis Imperfecta	15.9%
92	Congenital nystagmus	15.9%
93	Toxoplasmosis, Congenital	15.8%
94	Neuronal Ceroid-Lipofuscinoses	15.8%
95	Syphilis, Congenital	15.8%
96	Radiation Pneumonitis	15.6%
97	Radiation Fibrosis	15.6%
98	Pleuropneumonia	15.5%
99	Refsum Disease	15.5%
100	Polycystic Kidney Diseases	15.4%
101	Williams Syndrome	15.4%
102	Fabry Disease	15.3%
103	Tuberous Sclerosis	15.1%
104	Asbestosis	14.9%
105	Berylliosis	14.9%
106	Silicosis	14.9%
107	Asthma	14.8%
108	Glycogen storage disease type II	14.8%
109	Myotonic Dystrophy	14.7%
110	Fetal Diseases	14.6%
111	Zellweger Syndrome	14.4%
112	Pancreatic Cyst	14.3%
113	Lung Injury	14.3%
114	Paralysis, Obstetric	14.1%
115	Retinopathy of Prematurity	14.1%
116	Retinal Dysplasia	14.1%
117	Pulmonary Embolism	14%
118	Autoimmune Lymphoproliferative Syndrome	14%
119	Pulmonary Eosinophilia	14%
120	Eosinophilic Pneumonia	14%
121	Amino Acid Metabolism, Inborn Errors	14%
122	Aniridia	14%
123	Carbohydrate Metabolism, Inborn Errors	14%
124	Metal Metabolism, Inborn Errors	14%
125	Aspiration Pneumonia	14%
126	Progeria	14%
127	Lysosomal Storage Diseases	14%
128	Cytochrome-c Oxidase Deficiency	14%
129	Peroxisomal Disorders	14%
130	Classical Lissencephalies and Subcortical Band Heterotopias	14%
131	Porphyrias, Hepatic	13.9%
132	Kallmann Syndrome	13.9%
133	Epidermolysis Bullosa	13.7%
134	Angioedemas, Hereditary	13.7%
135	Amyloid Neuropathies, Familial	13.4%
136	Galactosemias	13.4%
137	Urea Cycle Disorders, Inborn	13.4%
138	Tyrosinemias	13.4%
139	Mucopolysaccharidosis III	13.4%
140	Bronchiolitis	13.3%
141	Esophageal Atresia	13%
142	Intestinal Atresia	13%
143	Gaucher Disease	12.8%
144	Chronic Obstructive Airway Disease	12.7%
145	Middle Lobe Syndrome	12.7%
146	Pancreatitis, Chronic	12.7%
147	Acute Lung Injury	12.7%
148	Polycystic Kidney, Autosomal Dominant	12.6%
149	Pancreatic Neoplasm	12.5%
150	Peutz-Jeghers Syndrome	12.5%
151	Choanal Atresia	12.4%
152	Laryngocele	12.4%
153	Pneumonia, Viral	12.2%
154	Optic Atrophy, Hereditary, Leber	12.2%
155	Tay-Sachs Disease	12.2%
156	Hyperphosphaturia	12.1%
157	Adenomatous Polyposis Coli	12%
158	Pneumonia, Bacterial	12%
159	Cutis Laxa	12%
160	Hemoptysis	12%
161	Retinitis Pigmentosa	11.9%
162	Pigmentary retinopathy	11.9%
163	Porokeratosis	11.9%
164	Keratoderma, Palmoplantar	11.9%
165	Chronic granulomatous disease	11.8%
166	Multiple Pulmonary Nodules	11.8%
167	Anus, Imperforate	11.8%
168	Anorectal Malformations	11.8%
169	Welander Distal Myopathy	11.7%
170	Canavan Disease	11.7%
171	Alexander Disease	11.7%
172	Homocystinuria	11.6%
173	Leigh Disease	11.5%
174	Niemann-Pick Disease, Type C	11.5%
175	Alkaptonuria	11.5%
176	Glycogen Storage Disease	11.5%
177	Hypophosphatasia	11.5%
178	Pneumonia, Lipid	11.5%
179	Propionic acidemia	11.5%
180	Dihydropyrimidine Dehydrogenase Deficiency	11.5%
181	Cystinosis	11.5%
182	Abnormalities, Drug-Induced	11.4%
183	Situs Inversus	11.4%
184	Choledochal Cyst	11.4%
185	Charcot-Marie-Tooth Disease	11.3%
186	Antley-Bixler Syndrome Phenotype	11.3%
187	Pseudoxanthoma Elasticum	11.2%
188	Variegate Porphyria	11.1%
189	Acute intermittent porphyria	11.1%
190	Porphyria Cutanea Tarda	11.1%
191	Aspergillosis, Allergic Bronchopulmonary	11%
192	Klinefelter Syndrome	10.9%
193	Carbamoyl-Phosphate Synthase I Deficiency Disease	10.9%
194	Anencephaly	10.8%
195	Ophthalmia Neonatorum	10.8%
196	Turner Syndrome	10.7%
197	Lactose Intolerance	10.6%
198	Bronchiolitis Obliterans	10.6%
199	Duane Retraction Syndrome	10.5%
200	Pulmonary Emphysema	10.5%
201	Histiocytosis, Langerhans-Cell	10.5%
202	Pancreatic Pseudocyst	10.5%
203	Pulmonary Aspergillosis	10.5%
204	Bronchopulmonary Aspergillosis	10.5%
205	Sarcoidosis, Pulmonary	10.4%
206	Pancreatitis, Alcoholic	10.4%
207	Pulmonary Infarction	10.4%
208	Zollinger-Ellison syndrome	10.3%
209	Myotonia Congenita	10.3%
210	Thrombasthenia	10.3%
211	Antithrombin III Deficiency	10.3%
212	Protein C Deficiency	10.3%
213	Brain Diseases, Metabolic, Inborn	10.3%
214	Glycogen Storage Disease Type I	10.3%
215	Glycogen Storage Disease Type V	10.3%
216	Xeroderma Pigmentosum	10.3%
217	Afibrinogenemia	10.3%
218	Dystonia Musculorum Deformans	10.3%
219	Factor VII Deficiency	10.3%
220	Factor X Deficiency	10.3%
221	Factor XII Deficiency	10.3%
222	Hemophilia A	10.3%
223	Leukomalacia, Periventricular	10.3%
224	Activated Protein C Resistance	10.3%
225	Factor II deficiency	10.3%
226	Factor VIII Deficiency	10.3%
227	Factor V deficiency	10.3%
228	Factor XI Deficiency	10.3%
229	Hypoprothrombinemias	10.3%
230	Fanconi Anemia	10.2%
231	Lafora Disease	10.2%
232	Unverricht-Lundborg Syndrome	10.2%
233	Anemia, Diamond-Blackfan	10.2%
234	Laryngostenosis	10.1%
235	Ataxia Telangiectasia	10%
236	Eye Abnormalities	9.8%
237	Hypolipoproteinemias	9.8%
238	Papillon-Lefevre Disease	9.8%
239	Cardiovascular Abnormalities	9.8%
240	Hyperlipidemia, Familial Combined	9.7%
241	Hyperlipoproteinemia Type III	9.7%
242	Pleurisy	9.5%
243	Skin Abnormalities	9.5%
244	Tracheitis	9.5%
245	Lymphatic Abnormalities	9.5%
246	Maxillofacial Abnormalities	9.5%
247	Dural Arteriovenous Fistula	9.5%
248	Congenital Microtia	9.5%
249	Dextrocardia	9.4%
250	Multiple Endocrine Neoplasia	9.4%
251	Congenital diaphragmatic hernia	9.4%
252	Basal Cell Nevus Syndrome	9.3%
253	Hydrops Fetalis	9.3%
254	Congenital Hypothyroidism	9.2%
255	Dermatitis, Atopic	9.2%
256	Farmer's Lung	9%
257	Granulomatosis with polyangiitis	8.8%
258	Biliary Tract Diseases	8.8%
259	Bronchial Diseases	8.8%
260	Gastrointestinal Diseases	8.8%
261	Liver diseases	8.8%
262	Pleural Diseases	8.8%
263	Respiration Disorders	8.8%
264	Thoracic Diseases	8.8%
265	Tracheal Diseases	8.8%
266	Genetic Diseases, Inborn	8.8%
267	Proctocolitis	8.8%
268	Hypoalphalipoproteinemias	8.7%
269	Familial Periodic Paralysis	8.6%
270	Granuloma, Laryngeal	8.6%
271	Hyperhomocysteinemia	8.5%
272	Acrocephalosyndactylia	8.5%
273	Renal Aminoacidurias	8.5%
274	Fanconi Syndrome	8.5%
275	Pseudohypoaldosteronism	8.5%
276	Liddle Syndrome	8.5%
277	Prune Belly Syndrome	8.5%
278	Twins, Conjoined	8.5%
279	Waardenburg Syndrome	8.5%
280	Hyperlipoproteinemia Type IV	8.4%
281	Hyperlipoproteinemia Type V	8.4%
282	Colorectal Neoplasms	8.4%
283	Urogenital Abnormalities	8.3%
284	Kernicterus	8.2%
285	Behcet Syndrome	8.2%
286	Blastomycosis	8.2%
287	Laryngitis	8.2%
288	Rhinitis	8.2%
289	Vocal Cord Dysfunction	8.2%
290	Biliary cirrhosis	8.1%
291	Gastrointestinal Neoplasms	8.1%
292	Liver neoplasms	8.1%
293	Microcephaly	8.1%
294	Macrocephaly	8.1%
295	Bronchial Fistula	8%
296	Pleural Neoplasms	8%
297	Fetal Growth Retardation	8%
298	Fetal Hypoxia	8%
299	Fetal Alcohol Spectrum Disorders	8%
300	Laryngomalacia	7.8%
301	Bile Duct Neoplasms	7.7%
302	gallbladder neoplasm	7.7%
303	Intestinal Neoplasms	7.7%
304	Stomach Neoplasms	7.7%
305	Anti-Glomerular Basement Membrane Disease	7.7%
306	Pleural Effusion, Malignant	7.7%
307	Gout	7.6%
308	Hypokalemic periodic paralysis	7.6%
309	Porencephaly	7.6%
310	Multiple Endocrine Neoplasia Type 1	7.6%
311	Pseudohypoparathyroidism	7.6%
312	Cystinuria	7.6%
313	Craniosynostosis	7.5%
314	Syndactyly	7.5%
315	Brachycephaly	7.5%
316	Friedreich Ataxia	7.5%
317	Laryngeal Diseases	7.5%
318	Nose Diseases	7.5%
319	Renal tubular acidosis	7.5%
320	Cecal Neoplasms	7.5%
321	Duodenal Neoplasms	7.5%
322	Transfusion-Related Acute Lung Injury	7.5%
323	Huntington Disease	7.4%
324	Invasive Pulmonary Aspergillosis	7.4%
325	Familial Hypophosphatemic Rickets	7.3%
326	Carcinoma, Pancreatic Ductal	7.3%
327	Digestive System Neoplasms	7.3%
328	Duodenitis	7.3%
329	Ileitis	7.3%
330	Respiratory Tract Infections	7.3%
331	Erosive Duodenitis	7.3%
332	Granuloma, Respiratory Tract	7.2%
333	Respiratory Hypersensitivity	7.2%
334	Respiratory Tract Fistula	7.2%
335	Cystic Fibrosis	7.1%
336	Laryngopharyngeal Reflux	7.1%
337	Anus Neoplasms	7.1%
338	Sigmoid Neoplasms	7.1%
339	Cleft Palate	7.1%
340	Mesenteric vascular insufficiency	7.1%
341	Anophthalmos	7.1%
342	Hydranencephaly	7.1%
343	Microphthalmos	7.1%
344	Neural Tube Defects	7.1%
345	Tethered Cord Syndrome	7.1%
346	Iniencephaly	7.1%
347	Craniorachischisis	7.1%
348	Limb Deformities, Congenital	7.1%
349	Exencephaly	7.1%
350	Septo-Optic Dysplasia	7.1%
351	Craniofacial Abnormalities	7.1%
352	Cortical Dysplasia	7.1%
353	Malformations of Cortical Development	7.1%
354	Peritoneal Neoplasms	7%
355	Mesenteric Vascular Occlusion	7%
356	Sinusitis	7%
357	Tracheal Neoplasms	7%
358	Bloom Syndrome	7%
359	Dysentery	7%
360	Enteritis	7%
361	Enterocolitis	7%
362	Esophageal and Gastric Varices	7%
363	Esophagitis	7%
364	Gastritis	7%
365	Inflammatory Bowel Diseases	7%
366	Cholecystolithiasis	7%
367	Intestinal Fistula	7%
368	Enterocutaneous Fistula	7%
369	Bronchial Neoplasms	6.9%
370	Chorioamnionitis	6.9%
371	Noonan Syndrome	6.8%
372	Esophageal Neoplasms	6.8%
373	Bronchomalacia	6.8%
374	Tracheomalacia	6.8%
375	Rectal Fistula	6.8%
376	Anal Fistula	6.8%
377	Arthritis, Gouty	6.7%
378	Nephroblastoma	6.7%
379	Poland Syndrome	6.7%
380	insulinoma	6.7%
381	Appendiceal Neoplasms	6.7%
382	Colonic Neoplasms	6.7%
383	Rectal Neoplasms	6.7%
384	Gastrinoma	6.7%
385	Glucagonoma	6.7%
386	Pouchitis	6.5%
387	Jaw Abnormalities	6.5%
388	Colitis	6.4%
389	Duodenogastric Reflux	6.4%
390	Peptic Ulcer	6.4%
391	Proctitis	6.4%
392	Choledocholithiasis	6.4%
393	Laryngeal neoplasm	6.3%
394	Abnormalities, Radiation-Induced	6.1%
395	Blepharophimosis	6.1%
396	Glycosuria, Renal	6.1%
397	Mouth Abnormalities	6.1%
398	Vipoma	6%
399	Horseshoe Kidney	6%
400	Pectus excavatum	6%
401	Klippel-Feil Syndrome	6%
402	Gastroschisis	6%
403	Synostosis	6%
404	Denys-Drash Syndrome	6%
405	Acrodermatitis	5.9%
406	Laryngospasm	5.9%
407	Lymphangiectasis, Intestinal	5.9%
408	Gianotti-Crosti Syndrome	5.9%
409	Gastrointestinal Stromal Tumors	5.9%
410	Asthma, Exercise-Induced	5.9%
411	Fatty Liver, Alcoholic	5.9%
412	Hepatitis, Alcoholic	5.9%
413	Liver Cirrhosis, Alcoholic	5.9%
414	Status Asthmaticus	5.9%
415	Micrognathism	5.9%
416	Pierre Robin Syndrome	5.9%
417	Amelia	5.8%
418	Arachnodactyly	5.8%
419	Ectopia Cordis	5.8%
420	Ectromelia	5.8%
421	Hemimelia	5.8%
422	Meningomyelocele	5.8%
423	Phocomelia	5.8%
424	Sirenomelia	5.8%
425	Spina Bifida	5.8%
426	Polydactyly	5.8%
427	Brachydactyly	5.8%
428	Plagiocephaly	5.8%
429	Lower Extremity Deformities, Congenital	5.8%
430	Upper Extremity Deformities, Congenital	5.8%
431	Single umbilical artery	5.8%
432	Crohn Disease	5.7%
433	Duodenal Obstruction	5.7%
434	Enterocolitis, Neutropenic	5.7%
435	Necrotizing Enterocolitis	5.7%
436	Altitude Sickness	5.7%
437	Bile Duct Diseases	5.7%
438	Bronchospasm	5.7%
439	Bronchiectasis	5.7%
440	Cholelithiasis	5.7%
441	Chylous Ascites	5.7%
442	Chylothorax	5.7%
443	Esophageal Diseases	5.7%
444	Fatty Liver	5.7%
445	Gastroenteritis	5.7%
446	Hepatitis	5.7%
447	Hydropneumothorax	5.7%
448	Hydrothorax	5.7%
449	Portal Hypertension	5.7%
450	Intestinal Diseases	5.7%
451	Liver Cirrhosis	5.7%
452	Pneumoperitoneum	5.7%
453	Pneumothorax	5.7%
454	Respiratory Insufficiency	5.7%
455	Stomach Diseases	5.7%
456	Tracheal Stenosis	5.7%
457	Bronchial Hyperreactivity	5.7%
458	Respiratory Depression	5.7%
459	Focal Nodular Hyperplasia	5.7%
460	Respiratory Failure	5.7%
461	Hepatic Insufficiency	5.7%
462	Steatohepatitis	5.7%
463	Eosinophilic Granuloma	5.7%
464	Paranasal Sinus Neoplasms	5.6%
465	Duodenal Ulcer	5.4%
466	Peptic Ulcer Perforation	5.4%
467	Gastric ulcer	5.4%
468	Appendicitis	5.4%
469	Retrognathia	5.3%
470	Arthrogryposis	5.3%
471	Asthma, Occupational	5.3%
472	Hermaphroditism	5.3%
473	Disorders of Sex Development	5.3%
474	Cryptorchidism	5.2%
475	Hypospadias	5.2%
476	Central Nervous System Cysts	5.2%
477	Dandy-Walker Syndrome	5.2%
478	Dermal Sinus	5.2%
479	Spina Bifida Cystica	5.2%
480	Spina Bifida Occulta	5.2%
481	Lissencephaly	5.2%
482	Polymicrogyria	5.2%
483	Pachygyria	5.2%
484	Schizencephaly	5.2%
485	Periventricular Nodular Heterotopia	5.2%
486	POEMS Syndrome	5.1%
487	Hepatocellular Adenoma	5.1%
488	MELAS Syndrome	5.1%
489	Nose Neoplasms	5%
490	Rhinoscleroma	5%
491	Colonic Pseudo-Obstruction	5%
492	Hyperandrogenism	5%
493	Aortic coarctation	4.9%
494	Cor Triatriatum	4.9%
495	Coronary Vessel Anomalies	4.9%
496	Dental Enamel Hypoplasia	4.9%
497	Patent ductus arteriosus	4.9%
498	Ebstein Anomaly	4.9%
499	Heart Septal Defects	4.9%
500	Hypodontia	4.9%
501	Macrostomia	4.9%
502	Meningocele	4.9%
503	Microstomia	4.9%
504	Tetralogy of Fallot	4.9%
505	Transposition of Great Vessels	4.9%
506	Hypoplastic Left Heart Syndrome	4.9%
507	May-Thurner Syndrome	4.9%
508	Encephalocele	4.9%
509	Craniofacial Dysostosis	4.9%
510	Prognathism	4.9%
511	Enterocolitis, Pseudomembranous	4.9%
512	Liver Diseases, Parasitic	4.9%
513	Wolff-Parkinson-White Syndrome	4.9%
514	pseudomembranous colitis	4.9%
515	Dysentery, Bacillary	4.9%
516	Hoarseness	4.8%
517	Granuloma, Lethal Midline	4.8%
518	Hepatic Veno-Occlusive Disease	4.8%
519	Laryngeal Edema	4.8%
520	Nose Deformities, Acquired	4.8%
521	Peliosis Hepatis	4.8%
522	Respiratory Aspiration	4.8%
523	Apnea	4.7%
524	Cheyne-Stokes Respiration	4.7%
525	Common Cold	4.7%
526	Dyspnea	4.7%
527	Gastrointestinal Hemorrhage	4.7%
528	Hemoperitoneum	4.7%
529	Hemothorax	4.7%
530	Hepatomegaly	4.7%
531	Hyperventilation	4.7%
532	Influenza	4.7%
533	Mesenteric Panniculitis	4.7%
534	Mouth Breathing	4.7%
535	Panniculitis, Peritoneal	4.7%
536	Peritonitis	4.7%
537	Tachypnea	4.7%
538	Peritoneal Fibrosis	4.7%
539	Catarrh	4.7%
540	Encapsulating Peritoneal Sclerosis	4.7%
541	Colitis, Ischemic	4.7%
542	Biliary Fistula	4.7%
543	Gastric Fistula	4.7%
544	Hay fever	4.7%
545	Rhinitis, Allergic, Perennial	4.7%
546	Hepatic Vein Thrombosis	4.7%
547	Liver Abscess	4.7%
548	Budd-Chiari Syndrome	4.7%
549	Severe Acute Respiratory Syndrome	4.7%
550	Tuberculosis, Gastrointestinal	4.7%
551	Pectus carinatum	4.7%
552	Bladder Exstrophy	4.6%
553	Epispadias	4.6%
554	Liver Abscess, Amebic	4.6%
555	Liver Neoplasms, Experimental	4.6%
556	Asthma, Aspirin-Induced	4.6%
557	Multicystic Dysplastic Kidney	4.6%
558	Maxillary Sinus Neoplasms	4.5%
559	Aortopulmonary Septal Defect	4.4%
560	Double Outlet Right Ventricle	4.4%
561	Endocardial Cushion Defects	4.4%
562	Myocardial bridging	4.4%
563	Aorticopulmonary Septal Defect	4.4%
564	Long QT Syndrome	4.3%
565	Platybasia	4.3%
566	Tricuspid Atresia	4.3%
567	Arrhythmogenic Right Ventricular Dysplasia	4.3%
568	Gonadal Dysgenesis	4.3%
569	Adrenogenital Syndrome	4.3%
570	Ovotesticular Disorders of Sex Development	4.3%
571	Airway Obstruction	4.2%
572	Cecal Diseases	4.2%
573	Choking	4.2%
574	Cholangitis	4.2%
575	Cholecystitis	4.2%
576	Cholestasis	4.2%
577	Colonic Diseases	4.2%
578	Common Bile Duct Diseases	4.2%
579	Epiglottitis	4.2%
580	Esophageal Stenosis	4.2%
581	Hepatitis, Chronic	4.2%
582	Ileal Diseases	4.2%
583	Intestinal Obstruction	4.2%
584	Intestinal Perforation	4.2%
585	Jejunal Diseases	4.2%
586	Mediastinitis	4.2%
587	Pneumatosis Cystoides Intestinalis	4.2%
588	Rectal Diseases	4.2%
589	Gastric Dilatation	4.2%
590	Liver Failure	4.2%
591	Gastric outlet obstruction	4.2%
592	Cronkhite-Canada Syndrome	4.2%
593	Non-alcoholic Fatty Liver Disease	4.2%
594	Chronic active hepatitis	4.2%
595	Intestinal Polyposis	4.2%
596	Truncus Arteriosus, Persistent	4.1%
597	Goldenhar Syndrome	4.1%
598	Pharyngitis	4.1%
599	Chemical and Drug Induced Liver Injury	4.1%
600	Nasal Polyps	4%
601	Hepatitis B, Chronic	4%
602	Hepatitis C, Chronic	4%
603	Hepatorenal Syndrome	4%
604	Pertussis	4%
605	Mandibulofacial Dysostosis	3.8%
606	Romano-Ward Syndrome	3.8%
607	Esophageal Perforation	3.6%
608	Hepatitis, Animal	3.6%
609	Hepatitis, Viral, Human	3.6%
610	Intestinal Diseases, Parasitic	3.6%
611	Talipes	3.6%
612	Voice Disorders	3.5%
613	Voice Disturbance	3.5%
614	Barrett Esophagus	3.5%
615	Deglutition Disorders	3.5%
616	Mediastinal Cyst	3.5%
617	Pericardial Cyst	3.5%
618	Thymic Cyst	3.5%
619	Epistaxis	3.5%
620	Cholestasis, Extrahepatic	3.5%
621	Biliary Dyskinesia	3.5%
622	Cholangitis, Sclerosing	3.5%
623	Colonic Diseases, Functional	3.5%
624	Esophageal motility disorders	3.5%
625	Fecal Incontinence	3.5%
626	Fecal Impaction	3.5%
627	Intussusception	3.5%
628	Mallory-Weiss Syndrome	3.5%
629	Megacolon	3.5%
630	Pyloric Stenosis	3.5%
631	Liver Failure, Acute	3.5%
632	Acalculous Cholecystitis	3.5%
633	End Stage Liver Disease	3.5%
634	Ileus	3.5%
635	Meconium ileus	3.5%
636	Achlorhydria	3.5%
637	Croup	3.5%
638	Liver Cirrhosis, Experimental	3.5%
639	Mediastinal Emphysema	3.5%
640	Rhinitis, Vasomotor	3.5%
641	Gastric Antral Vascular Ectasia	3.5%
642	Hypoventilation	3.5%
643	Congenital clubfoot	3.5%
644	Vertical Talus	3.5%
645	Acidosis, Respiratory	3.5%
646	Alkalosis, Respiratory	3.5%
647	Peptic Ulcer Hemorrhage	3.5%
648	Sleep Apnea Syndromes	3.5%
649	Gastroparesis	3.5%
650	Massive Hepatic Necrosis	3.1%
651	Esophageal Achalasia	3.1%
652	Anal Fissure	3.1%
653	Intestinal Pseudo-Obstruction	3.1%
654	Irritable Bowel Syndrome	3.1%
655	Superior Mesenteric Artery Syndrome	3.1%
656	Emphysematous Cholecystitis	3.1%
657	Neurogenic Bowel	3.1%
658	Sphincter of Oddi Dysfunction	3.1%
659	Anal Ulcer	3.1%
660	Vocal Cord Paralysis	3.1%
661	Arteriovenous fistula	3%
662	Fascioliasis	3%
663	Echinococcosis, Hepatic	3%
664	Melena	3%
665	Tonsillitis	3%
666	Chemical and Drug Induced Liver Injury, Chronic	3%
667	Dyspnea, Paroxysmal	3%
668	Respiratory Paralysis	3%
669	Reye Syndrome	3%
670	Hematemesis	2.9%
671	Hemorrhoids	2.9%
672	Autoimmune hepatitis	2.9%
673	Afferent Loop Syndrome	2.9%
674	Celiac Disease	2.9%
675	Short Bowel Syndrome	2.9%
676	Sprue, Tropical	2.9%
677	Steatorrhea	2.9%
678	Rectocele	2.9%
679	Sprue	2.9%
680	Diverticulitis	2.9%
681	Dumping Syndrome	2.9%
682	Rectal Prolapse	2.9%
683	Sleep Apnea, Obstructive	2.9%
684	Sleep Apnea, Central	2.9%
685	Pruritus Ani	2.6%
686	Aphonia	2.6%
687	Retropharyngeal Abscess	2.6%
688	Dysphonia	2.6%
689	Hepatitis, Viral, Animal	2.6%
690	Giardiasis	2.5%
691	Hepatitis E	2.5%
692	Hepatitis B	2.5%
693	Hepatitis C	2.5%
694	Diverticulum	2.5%
695	Hepatitis A	2.5%
696	Diverticulosis	2.5%
697	Hepatic Encephalopathy	2.5%
698	Nasopharyngitis	2.3%
699	Peritonsillar Abscess	2.1%
700	Cryptosporidiosis	1.7%
701	Rift Valley Fever	1.6%
702	CREST Syndrome	1.5%

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