MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Turner Syndrome

(UMLS:C0041408)

Definition:: A syndrome of defective gonadal development in phenotypic females associated with the karyotype 45,X (or 45,XO). Patients generally are of short stature with undifferentiated GONADS (streak gonads), SEXUAL INFANTILISM, HYPOGONADISM, webbing of the neck, cubitus valgus, elevated GONADOTROPINS, decreased ESTRADIOL level in blood, and CONGENITAL HEART DEFECTS. NOONAN SYNDROME (also called Pseudo-Turner Syndrome and Male Turner Syndrome) resembles this disorder; however, it occurs in males and females with a normal karyotype and is inherited as an autosomal dominant.
UMLS ID:: C0041408
MeSH ID:: D014424

Classification 1:

Name:

Male Urogenital Diseases
MeSH Tree Number(s):: C12.706.316.309.872|C12.706.316.795.750

Classification 2:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.875.253.309.872|C13.351.875.253.795.750

Classification 3:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.240.400.980|C14.280.400.980

Classification 4:

Name:

Congenital, Hereditary, and Neonatal Diseases and Abnormalities
MeSH Tree Number(s):: C16.131.240.400.970|C16.131.260.830.835.750|C16.131.939.316.309.872|C16.131.939.316.795.750|C16.320.180.830.835.750

Classification 5:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.391.119.309.872|C19.391.119.795.750

Synonym(s)

Turner Syndrome

45, X syndrome

45,X Gonadal Dysgenesis

45X Syndrome

45X0 - Turner's syndrome

Bonnevie-Ullrich Syndrome

DWARFISM, OVARIAN

Gonadal Dysgenesis

Karyotype 45, X

10.

Karyotype 45,X

11.

Monosomy X

12.

Morgagni-Turner

13.

Morgagni-Turner syndrome

14.

Morgagni-Turner-Albright syndrome

15.

Pterygolymphangiectasia syndrome

16.

Shereshevskii-Turner syndrome

17.

TS - Turner's syndrome

18.

TURNER SYNDROME

19.

TURNER-VARNY SYNDROME

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Chromium		6624699	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Klinefelter Syndrome	45.7%
2	Hyperandrogenism	38.1%
3	Adrenogenital Syndrome	35.4%
4	Ovotesticular Disorders of Sex Development	35.4%
5	Kallmann Syndrome	29.7%
6	Marfan Syndrome	28.6%
7	Dextrocardia	27.2%
8	Kartagener Syndrome	25.3%
9	Bladder Exstrophy	24.2%
10	Epispadias	24.2%
11	Horseshoe Kidney	24.2%
12	Holoprosencephaly	24%
13	Hypospadias	23.9%
14	Tricuspid Atresia	23.8%
15	Arrhythmogenic Right Ventricular Dysplasia	23.8%
16	Multicystic Dysplastic Kidney	23.3%
17	Noonan Syndrome	22.3%
18	Aortic coarctation	22%
19	Cor Triatriatum	22%
20	Coronary Vessel Anomalies	22%
21	Patent ductus arteriosus	22%
22	Ebstein Anomaly	22%
23	Heart Septal Defects	22%
24	Tetralogy of Fallot	22%
25	Transposition of Great Vessels	22%
26	Hypoplastic Left Heart Syndrome	22%
27	Beckwith-Wiedemann Syndrome	21.5%
28	Wolf-Hirschhorn Syndrome	21.5%
29	Turner Syndrome	21.3%
30	Cryptorchidism	20.7%
31	Rubinstein-Taybi Syndrome	20.6%
32	Smith-Magenis syndrome	20.3%
33	Cri-du-Chat Syndrome	20.2%
34	Down Syndrome	20.2%
35	Trisomy 21	20.2%
36	Aicardi's syndrome	20.1%
37	Denys-Drash Syndrome	19.3%
38	Prader-Willi Syndrome	19.1%
39	Gonadal Dysgenesis	18.8%
40	Ectopia Cordis	16.6%
41	Aortopulmonary Septal Defect	16.2%
42	Double Outlet Right Ventricle	16.2%
43	Endocardial Cushion Defects	16.2%
44	Myocardial bridging	16.2%
45	Aorticopulmonary Septal Defect	16.2%
46	Fragile X Syndrome	16.1%
47	Scimitar Syndrome	15.7%
48	Williams Syndrome	15.6%
49	Ectodermal Dysplasia	15.5%
50	Aplasia Cutis Congenita	15.5%
51	Dural Arteriovenous Fistula	15.1%
52	Long QT Syndrome	14.7%
53	Abnormalities, Drug-Induced	13.9%
54	Situs Inversus	13.9%
55	Wolff-Parkinson-White Syndrome	13.9%
56	CHARGE Syndrome	13.4%
57	Truncus Arteriosus, Persistent	13.3%
58	Eye Abnormalities	13.2%
59	Skin Abnormalities	13%
60	Lymphatic Abnormalities	13%
61	Congenital Microtia	13%
62	Congenital diaphragmatic hernia	13%
63	Nail-Patella Syndrome	12.7%
64	Cardiovascular Abnormalities	12.1%
65	Alstrom Syndrome	12%
66	Cockayne Syndrome	12%
67	Ichthyosis, X-Linked	11.9%
68	Polycystic Kidney Diseases	11.8%
69	Fetal Diseases	11.4%
70	Anencephaly	11.1%
71	Xeroderma	10.9%
72	Mobius Syndrome	10.9%
73	Abnormalities, Radiation-Induced	10.8%
74	May-Thurner Syndrome	10.7%
75	Romano-Ward Syndrome	10.7%
76	Cystic Fibrosis	10.7%
77	Maxillofacial Abnormalities	10.5%
78	Dwarfism	10.3%
79	Arteriovenous fistula	10.3%
80	Zellweger Syndrome	10%
81	Urologic Diseases	9.9%
82	Pseudoxanthoma Elasticum	9.8%
83	Urinary Bladder Fistula	9.7%
84	Single umbilical artery	9.7%
85	Smith-Lemli-Opitz Syndrome	9.5%
86	Retinal Dysplasia	9.5%
87	Aniridia	9.5%
88	Epidermolysis Bullosa	9.4%
89	Meconium Aspiration Syndrome	9.3%
90	Sjogren-Larsson Syndrome	8.7%
91	Testicular Diseases	8.7%
92	Myocardial Reperfusion Injury	8.6%
93	Ovarian Diseases	8.4%
94	Xeroderma Pigmentosum	8.1%
95	Acrocephalosyndactylia	8.1%
96	Genetic Diseases, Inborn	8.1%
97	Prune Belly Syndrome	7.8%
98	Twins, Conjoined	7.8%
99	Waardenburg Syndrome	7.8%
100	Myocardial Ischemia	7.8%
101	ovarian neoplasm	7.8%
102	Basal Cell Nevus Syndrome	7.7%
103	Albinism	7.6%
104	Angioedemas, Hereditary	7.6%
105	Primary Ciliary Dyskinesia	7.6%
106	Tuberous Sclerosis	7.6%
107	Craniosynostosis	7.5%
108	Syndactyly	7.5%
109	Brachycephaly	7.5%
110	Polycystic Kidney, Autosomal Dominant	7.5%
111	Anophthalmos	7.4%
112	Anus, Imperforate	7.4%
113	Hydranencephaly	7.4%
114	Microphthalmos	7.4%
115	Neural Tube Defects	7.4%
116	Tethered Cord Syndrome	7.4%
117	Iniencephaly	7.4%
118	Craniorachischisis	7.4%
119	Limb Deformities, Congenital	7.4%
120	Exencephaly	7.4%
121	Septo-Optic Dysplasia	7.4%
122	Craniofacial Abnormalities	7.4%
123	Cortical Dysplasia	7.4%
124	Malformations of Cortical Development	7.4%
125	Anorectal Malformations	7.4%
126	Bloom Syndrome	7.3%
127	Refsum Disease	7.2%
128	Tuberculosis, Renal	7.2%
129	Neoplastic Syndromes, Hereditary	7%
130	Hypogonadism	6.9%
131	Delayed Puberty	6.9%
132	Precocious Puberty	6.9%
133	Hypogonadotropic hypogonadism	6.9%
134	Testotoxicosis	6.9%
135	Blepharophimosis	6.9%
136	Laryngostenosis	6.9%
137	Mouth Abnormalities	6.9%
138	Multiple Epiphyseal Dysplasia	6.9%
139	Osteochondrodysplasias	6.9%
140	Pelger-Huet Anomaly	6.9%
141	Werner Syndrome	6.9%
142	Myasthenic Syndromes, Congenital	6.9%
143	Esophageal Atresia	6.9%
144	Intestinal Atresia	6.9%
145	Pectus excavatum	6.9%
146	Aortic Valve Stenosis	6.9%
147	Cardiomyopathy, Dilated	6.9%
148	Klippel-Feil Syndrome	6.9%
149	Pulmonary Valve Stenosis	6.9%
150	Gastroschisis	6.9%
151	Synostosis	6.9%
152	Chorioamnionitis	6.9%
153	Acrodermatitis	6.9%
154	Lymphangiectasis, Intestinal	6.9%
155	Gianotti-Crosti Syndrome	6.9%
156	Cleft Palate	6.9%
157	Testicular Neoplasms	6.9%
158	Anemia, Sickle Cell	6.9%
159	Thalassemia	6.9%
160	Muscular Dystrophy, Duchenne	6.8%
161	Urogenital Abnormalities	6.8%
162	Microcephaly	6.7%
163	Macrocephaly	6.7%
164	Arthrogryposis	6.6%
165	Choanal Atresia	6.6%
166	Tracheobronchomegaly	6.6%
167	Laryngocele	6.6%
168	Classical Lissencephalies and Subcortical Band Heterotopias	6.6%
169	Ataxia Telangiectasia	6.5%
170	Choledochal Cyst	6.5%
171	Central Nervous System Cysts	6.5%
172	Muscular Dystrophy	6.5%
173	Osteogenesis Imperfecta	6.5%
174	Dandy-Walker Syndrome	6.5%
175	Heart Block	6.5%
176	Tachycardia	6.5%
177	Tachyarrhythmia	6.5%
178	POEMS Syndrome	6.5%
179	Sick Sinus Syndrome	6.4%
180	Adrenoleukodystrophy	6.4%
181	Pregnancy Complications, Cardiovascular	6.4%
182	Laryngomalacia	6.2%
183	Pectus carinatum	6.2%
184	Menkes Kinky Hair Syndrome	6.2%
185	Autoimmune Lymphoproliferative Syndrome	6.2%
186	Congenital Hypothyroidism	6.1%
187	Wiskott-Aldrich Syndrome	6.1%
188	Jaw Abnormalities	6.1%
189	Oophoritis	6%
190	Nephroblastoma	5.9%
191	Myotonic Dystrophy	5.8%
192	Charcot-Marie-Tooth Disease	5.7%
193	Antley-Bixler Syndrome Phenotype	5.7%
194	Anuria	5.7%
195	Ureterolithiasis	5.7%
196	Nephrolithiasis	5.7%
197	Fetal Growth Retardation	5.7%
198	Fetal Hypoxia	5.7%
199	Fetal Alcohol Spectrum Disorders	5.7%
200	Hyperkeratosis, Epidermolytic	5.7%
201	Mucopolysaccharidosis II	5.7%
202	Hypertrophic Cardiomyopathy	5.6%
203	Hypertrophic obstructive cardiomyopathy	5.6%
204	Cardiac Tamponade	5.6%
205	Endocarditis	5.6%
206	Cardiac Arrest	5.6%
207	Heart failure	5.6%
208	Pericardial effusion	5.6%
209	Pericarditis	5.6%
210	Pneumopericardium	5.6%
211	Cor pulmonale	5.6%
212	Ventricular Outflow Obstruction	5.6%
213	Ventricular Dysfunction	5.6%
214	Cardiomyopathies	5.6%
215	Pleuropericarditis	5.6%
216	Porencephaly	5.5%
217	Urinary Bladder Diseases	5.4%
218	Infertility	5.4%
219	Kidney Diseases	5.4%
220	Ureteral Diseases	5.4%
221	Urethral Diseases	5.4%
222	Urination Disorders	5.4%
223	Urolithiasis	5.4%
224	Hepatolenticular Degeneration	5.4%
225	Bladder Neoplasm	5.4%
226	Kidney Neoplasm	5.4%
227	Ureteral Neoplasms	5.4%
228	Urethral Neoplasms	5.4%
229	Bacterial Endocarditis	5.4%
230	Abdominal Cramps	5.3%
231	Amniotic Band Syndrome	5.3%
232	Asphyxia Neonatorum	5.3%
233	Infant, Premature, Diseases	5.3%
234	Infantile Colic	5.3%
235	Fabry Disease	5.3%
236	Coronary Aneurysm	5.2%
237	Cardiac Output, High	5.2%
238	Myocardial Stunning	5.2%
239	Low Cardiac Output Syndrome	5.2%
240	Cardiomegaly	5.2%
241	Postpericardiotomy Syndrome	5.2%
242	Cardiac Hypertrophy	5.2%
243	Rheumatic Heart Disease	5.2%
244	Coronary heart disease	5.2%
245	Myocardial Infarction	5.2%
246	Orchitis	5.2%
247	Acute Coronary Syndrome	5.2%
248	Poland Syndrome	5.2%
249	Ovarian Hyperstimulation Syndrome	5.2%
250	Supravalvular aortic stenosis	5.2%
251	Lown-Ganong-Levine Syndrome	5.2%
252	Hyperphosphaturia	5.1%
253	Multiple Endocrine Neoplasia	5.1%
254	Urinary tract infection	5.1%
255	Urologic Neoplasms	5.1%
256	Diabetes Insipidus	5.1%
257	Glycosuria, Renal	5%
258	Anemia, Neonatal	5%
259	Persistent Fetal Circulation Syndrome	5%
260	Umbilical hernia	5%
261	Kounis Syndrome	4.9%
262	Sexually Transmitted Diseases	4.9%
263	Corpus Luteum Cyst	4.9%
264	Ovarian Cysts	4.9%
265	Angina Pectoris	4.8%
266	Anovulation	4.8%
267	Adams-Stokes Syndrome	4.8%
268	Atrioventricular Block	4.8%
269	Bundle-Branch Block	4.8%
270	Coronary Thrombosis	4.8%
271	Atrial Premature Complexes	4.8%
272	Sinoatrial Block	4.8%
273	Tachycardia, Paroxysmal	4.8%
274	Supraventricular tachycardia	4.8%
275	Tachycardia, Ventricular	4.8%
276	Tachycardia, Reciprocating	4.8%
277	Coronary Artery Disease	4.8%
278	granulosa cell tumor	4.8%
279	Carcinoma, Ovarian Epithelial	4.8%
280	Kidney Calculi	4.8%
281	Ureteral Calculi	4.8%
282	Varicocele	4.8%
283	Genital Herpes	4.8%
284	Diabetic Cardiomyopathies	4.7%
285	Bladder neck obstruction	4.7%
286	Neonatal Abstinence Syndrome	4.7%
287	Amyloid Neuropathies, Familial	4.7%
288	Vascular Diseases	4.7%
289	Embolism, Amniotic Fluid	4.7%
290	Congenital nystagmus	4.7%
291	Toxoplasmosis, Congenital	4.7%
292	Renal hypertension	4.6%
293	Renal Artery Obstruction	4.6%
294	Renal Artery Stenosis	4.6%
295	Syphilis, Congenital	4.6%
296	Vesicovaginal Fistula	4.6%
297	Neuronal Ceroid-Lipofuscinoses	4.6%
298	Carcinoma, Endometrioid	4.6%
299	Carcinoid Heart Disease	4.5%
300	Amelia	4.5%
301	Arachnodactyly	4.5%
302	Ectromelia	4.5%
303	Hemimelia	4.5%
304	Meningomyelocele	4.5%
305	Phocomelia	4.5%
306	Sirenomelia	4.5%
307	Spina Bifida	4.5%
308	Polydactyly	4.5%
309	Brachydactyly	4.5%
310	Plagiocephaly	4.5%
311	Lower Extremity Deformities, Congenital	4.5%
312	Upper Extremity Deformities, Congenital	4.5%
313	Behcet Syndrome	4.4%
314	Rett Syndrome	4.4%
315	Congenital Hyperinsulinism	4.4%
316	Micrognathism	4.4%
317	Pierre Robin Syndrome	4.4%
318	Dental Enamel Hypoplasia	4.2%
319	Diabetic Nephropathy	4.2%
320	Hypodontia	4.2%
321	Macrostomia	4.2%
322	Meningocele	4.2%
323	Microstomia	4.2%
324	Encephalocele	4.2%
325	Craniofacial Dysostosis	4.2%
326	Adrenal Gland Diseases	4.2%
327	Genital Diseases, Male	4.2%
328	Parathyroid Diseases	4.2%
329	Thyroid Diseases	4.2%
330	Sickle Cell Trait	4.2%
331	Retrognathia	4.2%
332	Familial Mediterranean Fever	4.1%
333	Adrenal Gland Neoplasms	4.1%
334	Genital Neoplasms, Male	4.1%
335	Tachycardia, Atrioventricular Nodal Reentry	4%
336	Tachycardia, Ectopic Atrial	4%
337	Tachycardia, Ectopic Junctional	4%
338	Sinus Tachycardia	4%
339	Torsades de Pointes	4%
340	Accelerated Idioventricular Rhythm	4%
341	Platybasia	4%
342	Leukomalacia, Periventricular	4%
343	Bronchomalacia	4%
344	Tracheomalacia	4%
345	Renal Aminoacidurias	4%
346	Fanconi Syndrome	4%
347	Pseudohypoaldosteronism	4%
348	Liddle Syndrome	4%
349	Pregnancy Complications	4%
350	Prognathism	4%
351	Bone Diseases, Endocrine	3.9%
352	Endocrine Gland Neoplasms	3.9%
353	Diabetes Mellitus	3.9%
354	Pituitary Diseases	3.9%
355	Canavan Disease	3.9%
356	Alexander Disease	3.9%
357	Ophthalmia Neonatorum	3.9%
358	Diabetic Angiopathies	3.9%
359	Amino Acid Metabolism, Inborn Errors	3.9%
360	Carbohydrate Metabolism, Inborn Errors	3.9%
361	Metal Metabolism, Inborn Errors	3.9%
362	Progeria	3.9%
363	Lysosomal Storage Diseases	3.9%
364	Cytochrome-c Oxidase Deficiency	3.9%
365	Peroxisomal Disorders	3.9%
366	Gestational Diabetes	3.9%
367	Coronary Occlusion	3.9%
368	Microvascular Angina	3.9%
369	Coronary Stenosis	3.9%
370	ST segment elevation myocardial infarction	3.9%
371	Parathyroid Neoplasms	3.8%
372	Thyroid Neoplasm	3.8%
373	Thyroid carcinoma	3.8%
374	Hydrops Fetalis	3.8%
375	Acute Chest Syndrome	3.8%
376	Renal tubular acidosis	3.8%
377	Galactosemias	3.7%
378	Urea Cycle Disorders, Inborn	3.7%
379	Tyrosinemias	3.7%
380	Aortic Valve Insufficiency	3.7%
381	Restrictive cardiomyopathy	3.7%
382	Endocardial Fibroelastosis	3.7%
383	Heart Rupture, Post-Infarction	3.7%
384	Mitral Valve Insufficiency	3.7%
385	Mitral Valve Stenosis	3.7%
386	Myocarditis	3.7%
387	Pericarditis, Constrictive	3.7%
388	Pulmonary Valve Insufficiency	3.7%
389	Tricuspid Valve Insufficiency	3.7%
390	Tricuspid Valve Stenosis	3.7%
391	Ventricular Dysfunction, Left	3.7%
392	Right Ventricular Dysfunction	3.7%
393	Endomyocardial Fibrosis	3.7%
394	Carditis	3.7%
395	Heart Failure, Systolic	3.7%
396	Heart Failure, Diastolic	3.7%
397	Cutis Laxa	3.7%
398	Hermaphroditism	3.7%
399	Disorders of Sex Development	3.7%
400	Retinitis Pigmentosa	3.7%
401	Pigmentary retinopathy	3.7%
402	Porokeratosis	3.6%
403	Keratoderma, Palmoplantar	3.6%
404	Chronic granulomatous disease	3.6%
405	Shock, Cardiogenic	3.6%
406	Welander Distal Myopathy	3.6%
407	Uterine Neoplasms	3.6%
408	Vaginal Neoplasms	3.6%
409	Vulvar Neoplasms	3.6%
410	Uterine Cancer	3.6%
411	Angina, Unstable	3.6%
412	Subacute Bacterial Endocarditis	3.6%
413	Optic Atrophy, Hereditary, Leber	3.6%
414	Duane Retraction Syndrome	3.5%
415	Retinal Vein Occlusion	3.5%
416	Endometriosis	3.5%
417	Uterine Diseases	3.5%
418	Vaginal Diseases	3.5%
419	Vulvar Diseases	3.5%
420	Endometrioma	3.5%
421	Aortic Aneurysm	3.4%
422	Aortitis	3.4%
423	Sinus Arrhythmia	3.4%
424	Atrial Fibrillation	3.4%
425	Atrial Flutter	3.4%
426	Edema, Cardiac	3.4%
427	Leriche Syndrome	3.4%
428	Periphlebitis	3.4%
429	Phlebitis	3.4%
430	Thromboangiitis Obliterans	3.4%
431	Ventricular Fibrillation	3.4%
432	Ventricular Flutter	3.4%
433	Porphyrias, Hepatic	3.4%
434	Parasystole	3.4%
435	Paroxysmal atrial fibrillation	3.4%
436	Bradycardia	3.4%
437	Cardiomyopathy, Alcoholic	3.4%
438	Sudden Cardiac Death	3.4%
439	Left Ventricular Hypertrophy	3.4%
440	Right Ventricular Hypertrophy	3.4%
441	Chagas Cardiomyopathy	3.4%
442	Peutz-Jeghers Syndrome	3.4%
443	Aortic Rupture	3.4%
444	Glycogen storage disease type II	3.4%
445	Myotonia Congenita	3.4%
446	Penile Neoplasms	3.4%
447	Prostatic Neoplasms	3.4%
448	Thrombasthenia	3.4%
449	Antithrombin III Deficiency	3.4%
450	Protein C Deficiency	3.4%
451	Brain Diseases, Metabolic, Inborn	3.4%
452	Afibrinogenemia	3.4%
453	Dystonia Musculorum Deformans	3.4%
454	Factor VII Deficiency	3.4%
455	Factor X Deficiency	3.4%
456	Factor XII Deficiency	3.4%
457	Hemophilia A	3.4%
458	Activated Protein C Resistance	3.4%
459	Factor II deficiency	3.4%
460	Factor VIII Deficiency	3.4%
461	Factor V deficiency	3.4%
462	Factor XI Deficiency	3.4%
463	Hypoprothrombinemias	3.4%
464	Thrombophlebitis	3.4%
465	Fanconi Anemia	3.4%
466	Lafora Disease	3.4%
467	Unverricht-Lundborg Syndrome	3.4%
468	Anemia, Diamond-Blackfan	3.4%
469	Moyamoya Disease	3.4%
470	Mesoblastic Nephroma	3.4%
471	Renal Cell Carcinoma	3.4%
472	Papillary Renal Cell Carcinoma	3.4%
473	Polycystic Ovary Syndrome	3.3%
474	Pyelocystitis	3.3%
475	Dermatitis, Atopic	3.2%
476	Malignant Atrophic Papulosis	3.2%
477	Genital Neoplasms, Female	3.2%
478	Dyspnea, Paroxysmal	3.2%
479	Shwartzman Phenomenon	3.2%
480	Cystitis	3.2%
481	Hydronephrosis	3.2%
482	Hyperoxaluria	3.2%
483	Kidney Cortex Necrosis	3.2%
484	Kidney Papillary Necrosis	3.2%
485	Nephritis	3.2%
486	Nephrosclerosis	3.2%
487	Nephrosis	3.2%
488	Perinephritis	3.2%
489	Kidney Failure	3.2%
490	Uremia	3.2%
491	Ureteral obstruction	3.2%
492	Ureterocele	3.2%
493	Urethral Obstruction	3.2%
494	Urethritis	3.2%
495	Vesico-Ureteral Reflux	3.2%
496	Urinary Retention	3.2%
497	Oxalosis	3.2%
498	Renal Insufficiency	3.2%
499	Hypertension, Renovascular	3.2%
500	Endometritis	3.2%
501	Carotid Artery Thrombosis	3.2%
502	Coronary Restenosis	3.2%
503	Dermal Sinus	3.1%
504	Spina Bifida Cystica	3.1%
505	Spina Bifida Occulta	3.1%
506	Lissencephaly	3.1%
507	Polymicrogyria	3.1%
508	Pachygyria	3.1%
509	Schizencephaly	3.1%
510	Periventricular Nodular Heterotopia	3.1%
511	Pituitary Adenoma	3.1%
512	Pituitary Neoplasms	3.1%
513	Renal Osteodystrophy	3.1%
514	Renal rickets	3.1%
515	Multiple Endocrine Neoplasia Type 1	3.1%
516	Leydig Cell Tumor	3%
517	Hepatorenal Syndrome	3%
518	Dyspareunia	3%
519	Pituitary Apoplexy	3%
520	Diabetic Foot	3%
521	Bacteriuria	3%
522	Glycosuria	3%
523	Hematuria	3%
524	Oliguria	3%
525	Polyuria	3%
526	Proteinuria	3%
527	Pyuria	3%
528	Urinary Calculi	3%
529	Cystocele	3%
530	Nephrocalcinosis	3%
531	Urinary Incontinence	3%
532	Fallopian Tube Neoplasms	3%
533	Postphlebitic Syndrome	3%
534	Uterine Inversion	3%
535	Angina Pectoris, Variant	3%
536	Homocystinuria	3%
537	Leigh Disease	3%
538	Huntington Disease	2.9%
539	Giant Cell Arteritis	2.9%
540	Temporal Arteritis	2.9%
541	Vasculitis, Central Nervous System	2.9%
542	Familial Hypophosphatemic Rickets	2.9%
543	Enuresis	2.9%
544	Uterine Rupture	2.8%
545	Cystinuria	2.8%
546	Pyelonephritis	2.8%
547	Intracranial Embolism and Thrombosis	2.8%
548	Carotid Stenosis	2.8%
549	Intracranial Aneurysm	2.8%
550	Paralysis, Obstetric	2.8%
551	Retinopathy of Prematurity	2.8%
552	Bronchopulmonary Dysplasia	2.8%
553	Aneurysm	2.8%
554	Angiomatosis	2.8%
555	Aortic Diseases	2.8%
556	Arterial Occlusive Diseases	2.8%
557	Hyperemia	2.8%
558	Hypotension	2.8%
559	Superior Vena Cava Syndrome	2.8%
560	Telangiectasis	2.8%
561	Vasculitis	2.8%
562	Venous Insufficiency	2.8%
563	Peripheral Vascular Diseases	2.8%
564	Embolism and Thrombosis	2.8%
565	Angiodysplasia	2.8%
566	Capillary Leak Syndrome	2.8%
567	Prehypertension	2.8%
568	Aortic Valve Prolapse	2.8%
569	Tricuspid Valve Prolapse	2.8%
570	Takotsubo Cardiomyopathy	2.8%
571	Mandibulofacial Dysostosis	2.7%
572	AIDS-Associated Nephropathy	2.7%
573	Blue Toe Syndrome	2.7%
574	Mucopolysaccharidosis III	2.7%
575	Respiratory Distress Syndrome, Newborn	2.7%
576	Adenomatous Polyposis Coli	2.6%
577	Vascular System Injuries	2.6%
578	Compartment syndromes	2.6%
579	Hepatic Veno-Occlusive Disease	2.6%
580	Peliosis Hepatis	2.6%
581	Cerebrovascular Disorders	2.6%
582	Reperfusion Injury	2.6%
583	Splenic Infarction	2.6%
584	Cerebrovascular Insufficiency	2.6%
585	Vascular Neoplasms	2.6%
586	Spinal Cord Vascular Diseases	2.6%
587	Vasoplegia	2.6%
588	Hemorrhoids	2.6%
589	Thoracic Outlet Syndrome	2.6%
590	Aortic Aneurysm, Abdominal	2.6%
591	Aortic Aneurysm, Thoracic	2.6%
592	Sinus Arrest, Cardiac	2.6%
593	Salpingitis	2.6%
594	Vulvovaginitis	2.6%
595	Subarachnoid Hemorrhage, Traumatic	2.6%
596	Carotid Artery, Internal, Dissection	2.6%
597	Gaucher Disease	2.5%
598	MELAS Syndrome	2.5%
599	Lemierre Syndrome	2.5%
600	Hand-Arm Vibration Syndrome	2.5%
601	Nesidioblastosis	2.5%
602	Optic Neuropathy, Ischemic	2.4%
603	Anterior Ischemic Optic Neuropathy	2.4%
604	Mesenteric vascular insufficiency	2.4%
605	Diabetic Retinopathy	2.4%
606	Angioedema	2.4%
607	Colitis, Ischemic	2.4%
608	Polyarteritis Nodosa	2.4%
609	Takayasu Arteritis	2.4%
610	Intracranial Arteriosclerosis	2.4%
611	Cerebral Atherosclerosis	2.4%
612	Cerebral Arteriosclerosis	2.4%
613	Endometrial Neoplasms	2.4%
614	Carbamoyl-Phosphate Synthase I Deficiency Disease	2.4%
615	CREST Syndrome	2.4%
616	Alkaptonuria	2.4%
617	Glycogen Storage Disease	2.4%
618	Hypophosphatasia	2.4%
619	Propionic acidemia	2.4%
620	Dihydropyrimidine Dehydrogenase Deficiency	2.4%
621	Cystinosis	2.4%
622	Infarction, Middle Cerebral Artery	2.4%
623	Infarction, Anterior Cerebral Artery	2.4%
624	Infarction, Posterior Cerebral Artery	2.4%
625	Heart Diseases	2.3%
626	Adrenal Cortex Diseases	2.3%
627	Epididymitis	2.3%
628	Euthyroid Sick Syndromes	2.3%
629	Goiter	2.3%
630	Hyperparathyroidism	2.3%
631	Hyperthyroidism	2.3%
632	Hyperthyroxinemia	2.3%
633	Hypoparathyroidism	2.3%
634	Hypothyroidism	2.3%
635	Penile Diseases	2.3%
636	Prostatic Diseases	2.3%
637	Spermatic Cord Torsion	2.3%
638	Thyroiditis	2.3%
639	Hemospermia	2.3%
640	Testicular Hydrocele	2.3%
641	Secondary hypothyroidism	2.3%
642	Primary Hyperthyroidism	2.3%
643	Primary Hypothyroidism	2.3%
644	Graves Disease	2.3%
645	Thyroid Nodule	2.3%
646	Prostatic Neoplasms, Castration-Resistant	2.3%
647	Brain Infarction	2.3%
648	Goldenhar Syndrome	2.3%
649	Kearns-Sayre syndrome	2.2%
650	Kernicterus	2.2%
651	Hypolipoproteinemias	2.2%
652	Papillon-Lefevre Disease	2.2%
653	Hyperlipidemia, Familial Combined	2.2%
654	Hyperlipoproteinemia Type III	2.2%
655	Cerebral Thrombosis	2.2%
656	Intracranial Embolism	2.2%
657	Intracranial Thrombosis	2.2%
658	Spermatocele	2.2%
659	Empty Sella Syndrome	2.2%
660	Hyperpituitarism	2.2%
661	Hypopituitarism	2.2%
662	Hypophysitis	2.2%
663	Abruptio Placentae	2.2%
664	Placenta Accreta	2.2%
665	Vertebral Artery Dissection	2.2%
666	Prolactinoma	2.2%
667	Growth Hormone-Secreting Pituitary Adenoma	2.2%
668	Glomerulonephritis	2.1%
669	Nephritis, Interstitial	2.1%
670	Lipoid nephrosis	2.1%
671	Nephrotic Syndrome	2.1%
672	Pyelitis	2.1%
673	Pyonephrosis	2.1%
674	Urethral Stenosis	2.1%
675	Nephrogenic Diabetes Insipidus	2.1%
676	Congenital Nephrogenic Diabetes Insipidus	2.1%
677	Acute kidney injury	2.1%
678	Urethral stricture	2.1%
679	Adrenocortical carcinoma	2.1%
680	Talipes	2.1%
681	Familial Periodic Paralysis	2.1%
682	Lactose Intolerance	2.1%
683	Variegate Porphyria	2.1%
684	Acute intermittent porphyria	2.1%
685	Porphyria Cutanea Tarda	2.1%
686	Hyperhomocysteinemia	2.1%
687	Polyhydramnios	2.1%
688	Obstetric Labor Complications	2.1%
689	Ectopic Pregnancy	2.1%
690	Pregnancy, Prolonged	2.1%
691	Puerperal Disorders	2.1%
692	Oligohydramnios	2.1%
693	Prenatal Injuries	2.1%
694	Hyperlipoproteinemia Type IV	2.1%
695	Hyperlipoproteinemia Type V	2.1%
696	Endometrial Hyperplasia	2.1%
697	Pyometra	2.1%
698	Vaginitis	2.1%
699	Vulvitis	2.1%
700	Vaginal Discharge	2.1%
701	Vulvodynia	2.1%
702	Carotid Artery Injuries	2%
703	Latent Autoimmune Diabetes in Adults	2%
704	Diabetes Mellitus, Experimental	2%
705	Niemann-Pick Disease, Type C	2%
706	Puerperal Infection	2%
707	Azotemia	2%
708	Postpartum Hemorrhage	2%
709	Albuminuria	2%
710	Hemoglobinuria	2%
711	Urge Incontinence	2%
712	Deformity	2%
713	Gout	2%
714	Pseudohypoparathyroidism	2%
715	Pregnancy Complications, Neoplastic	2%
716	Friedreich Ataxia	2%
717	Pregnancy Complications, Hematologic	2%
718	Pregnancy Complications, Infectious	2%
719	Fetal Death	1.9%
720	Perinatal death	1.9%
721	Morning Sickness	1.9%
722	Adnexitis	1.9%
723	Pruritus Vulvae	1.9%
724	Uterine hemorrhage	1.9%
725	Vaginal Fistula	1.9%
726	Pelvic Inflammatory Disease	1.9%
727	Uterine Prolapse	1.9%
728	Vaginal Prolapse	1.9%
729	Uterine Cervical Incompetence	1.9%
730	Tay-Sachs Disease	1.9%
731	Sinus Thrombosis, Intracranial	1.9%
732	Diurnal Enuresis	1.9%
733	Hemolytic-Uremic Syndrome	1.9%
734	Cerebral Infarction	1.9%
735	Brain Stem Infarctions	1.9%
736	Basal Ganglia Hemorrhage	1.9%
737	Aneurysm, Dissecting	1.8%
738	Arteriosclerosis	1.8%
739	Arteritis	1.8%
740	Embolism	1.8%
741	Erythromelalgia	1.8%
742	Fibromuscular Dysplasia	1.8%
743	Malignant Hypertension	1.8%
744	Raynaud Disease	1.8%
745	Thromboembolism	1.8%
746	Thrombosis	1.8%
747	Essential Hypertension	1.8%
748	Aneurysm, Ruptured	1.8%
749	Iliac Aneurysm	1.8%
750	Pulmonary artery stenosis	1.8%
751	White Coat Hypertension	1.8%
752	Systemic Vasculitis	1.8%
753	Embolus	1.8%
754	Pancreatic Neoplasm	1.8%
755	Congenital clubfoot	1.8%
756	Vertical Talus	1.8%
757	Candidiasis, Vulvovaginal	1.8%
758	Chlamydia Infections	1.8%
759	Gonorrhea	1.8%
760	Cavernous Sinus Thrombosis	1.8%
761	Sagittal Sinus Thrombosis	1.8%
762	Retinal Artery Occlusion	1.7%
763	Retinal Vasculitis	1.7%
764	Hypertensive Retinopathy	1.7%
765	Anterior Compartment Syndrome	1.7%
766	Vasculitis, Leukocytoclastic, Cutaneous	1.7%
767	Gastric Antral Vascular Ectasia	1.7%
768	Abdominal Compartment Syndrome	1.7%
769	Carotid Artery Diseases	1.7%
770	Brain Ischemia	1.7%
771	Hypotension, Orthostatic	1.7%
772	Cerebrovascular accident	1.7%
773	Varicose Ulcer	1.7%
774	Vasospasm, Intracranial	1.7%
775	Spinal Cord Ischemia	1.7%
776	Intracranial Arterial Diseases	1.7%
777	Primary Graft Dysfunction	1.7%
778	Post-Exercise Hypotension	1.7%
779	Syphilis	1.7%
780	Lateral Medullary Syndrome	1.7%
781	Mesenteric Vascular Occlusion	1.6%
782	Mucocutaneous Lymph Node Syndrome	1.6%
783	Sturge-Weber Syndrome	1.6%
784	Livedo Reticularis	1.6%
785	Hyaline Membrane Disease	1.6%
786	Lupus Vasculitis, Central Nervous System	1.6%
787	Hemangioma, Cavernous	1.6%
788	Basal Ganglia Cerebrovascular Disease	1.6%
789	Vascular Headaches	1.6%
790	Scurvy	1.6%
791	Dementia, Vascular	1.6%
792	Glycogen Storage Disease Type I	1.6%
793	Glycogen Storage Disease Type V	1.6%
794	Balkan Nephropathy	1.6%
795	Focal glomerulosclerosis	1.6%
796	Kidney Failure, Chronic	1.6%
797	Putaminal Hemorrhage	1.6%
798	Glomerulonephritis, Membranoproliferative	1.5%
799	Ischemic contracture	1.5%
800	Cryoglobulinemia	1.5%
801	Nelson Syndrome	1.5%
802	Hypoalphalipoproteinemias	1.5%
803	Shy-Drager Syndrome	1.4%
804	Purpura, Hyperglobulinemic	1.4%
805	Anti-Glomerular Basement Membrane Disease	1.4%
806	Lupus Nephritis	1.4%
807	Hypokalemic periodic paralysis	1.4%
808	Endometrial Stromal Sarcoma	1.4%
809	Atypical Hemolytic Uremic Syndrome	1.4%
810	Balanitis	1.4%
811	Benign prostatic hypertrophy	1.4%
812	Cushing Syndrome	1.4%
813	Hyperaldosteronism	1.4%
814	Hyperparathyroidism, Secondary	1.4%
815	Hypoaldosteronism	1.4%
816	Phimosis	1.4%
817	Priapism	1.4%
818	prostatitis	1.4%
819	Thyrotoxicosis	1.4%
820	Hyperparathyroidism, Primary	1.4%
821	Prostatic Adenoma	1.4%
822	Benign Prostatic Hyperplasia	1.4%
823	Prostatic Hypertrophy	1.4%
824	Prostatic Hyperplasia	1.4%
825	Thyroid Hormone Resistance Syndrome	1.4%
826	Arteriosclerosis Obliterans	1.4%
827	Atherosclerosis	1.4%
828	Air Embolism	1.4%
829	Endarteritis	1.4%
830	Venous Thrombosis	1.4%
831	Deep Vein Thrombosis	1.4%
832	Venous Thromboembolism	1.4%
833	Uterine Cervicitis	1.4%
834	Leukorrhea	1.4%
835	Parametritis	1.4%
836	Waldenstrom Macroglobulinemia	1.4%
837	Multiple Myeloma	1.4%
838	Arthritis, Gouty	1.3%
839	Lymphogranuloma Venereum	1.3%
840	Addison Disease	1.3%
841	Premature Ejaculation	1.3%
842	Erectile dysfunction	1.3%
843	Autoimmune thyroiditis	1.3%
844	Primary Adrenal Insufficiency	1.3%
845	Intermittent Claudication	1.3%
846	Pulmonary Embolism	1.3%
847	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	1.3%
848	Bacterial Vaginosis	1.3%
849	Diabetic Neuropathies	1.3%
850	Myxedema	1.3%
851	Diabetic Amyotrophy	1.3%
852	Diabetic Autonomic Neuropathy	1.3%
853	No-Reflow Phenomenon	1.3%
854	Trichomonas Vaginitis	1.3%
855	Uterine Perforation	1.3%
856	Hyperprolactinemia	1.3%
857	Cerebral Arterial Diseases	1.3%
858	Metrorrhagia	1.3%
859	Vertebrobasilar Insufficiency	1.3%
860	Anterior Spinal Artery Syndrome	1.3%
861	Basilar Artery Stenosis	1.3%
862	Vertebral Artery Stenosis	1.3%
863	Intracranial Hemorrhage, Hypertensive	1.3%
864	Transient Cerebral Ischemia	1.3%
865	Gigantism	1.2%
866	Acromegaly	1.2%
867	Diabetic Ketoacidosis	1.2%
868	Menorrhagia	1.2%
869	Subarachnoid Hemorrhage	1.2%
870	Hypoxia-Ischemia, Brain	1.2%
871	Cerebral Hemorrhage	1.2%
872	Premature Menopause	1.2%
873	Hereditary Angioedema Type III	1.2%
874	Hereditary Angioedema Types I and II	1.2%
875	Abortion, Habitual	1.2%
876	Dystocia	1.2%
877	Eclampsia	1.2%
878	Fetal Membranes, Premature Rupture	1.2%
879	Placental Insufficiency	1.2%
880	Pre-Eclampsia	1.2%
881	Prenatal Exposure Delayed Effects	1.2%
882	HELLP Syndrome	1.2%
883	Placenta, Retained	1.2%
884	Abortion, Veterinary	1.1%
885	Pregnancy Complications, Parasitic	1.1%
886	Hepatic Vein Thrombosis	1.1%
887	Budd-Chiari Syndrome	1.1%
888	Lactation Disorder	1.1%
889	Mastitis	1.1%
890	Depression, Postpartum	1.1%
891	Embryo Loss	1.1%
892	Rheumatoid Vasculitis	1.1%
893	Fetal Resorption	1.1%
894	Hyperemesis Gravidarum	1.1%
895	Pulmonary Infarction	1.1%
896	Subclavian Steal Syndrome	1.1%
897	Trophoblastic Neoplasms	1%
898	Granulomatosis with polyangiitis	1%
899	Breech Presentation	1%
900	Stillbirth	1%
901	Cerebral Amyloid Angiopathy	1%
902	Carcinoma, Pancreatic Ductal	1%
903	Azoospermia	0.9%
904	Hyperglycemic Hyperosmolar Nonketotic Coma	0.9%
905	Oligospermia	0.9%
906	Impotence, Vasculogenic	0.9%
907	Asthenozoospermia	0.9%
908	Teratozoospermia	0.9%
909	Hashimoto Disease	0.9%
910	Aspermia	0.9%
911	Waterhouse-Friderichsen Syndrome	0.9%
912	Hematoma, Subdural	0.8%
913	Hematoma, Epidural, Cranial	0.8%
914	Brain Hemorrhage, Traumatic	0.8%
915	Hematoma, Subdural, Intracranial	0.8%
916	Hematoma, Subdural, Chronic	0.8%
917	Hematoma, Subdural, Acute	0.8%
918	Premature Birth	0.7%
919	insulinoma	0.7%
920	Gastrinoma	0.7%
921	Glucagonoma	0.7%
922	Galactorrhea	0.6%
923	Vipoma	0.6%
924	Choriocarcinoma	0.6%
925	Hydatidiform Mole	0.4%

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