MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Kounis Syndrome

(UMLS:C2609176)

Definition:: A disorder of cardiac function secondary to hypersensitivity reactions. It is characterized by coexistence of acute coronary syndromes and cardiac MAST CELL and PLATELET ACTIVATION. It may be induced by exposure to drugs (e.g., antibiotics, anesthetics, contrast media), food, and environmental triggers (e.g., insect bites and stings, poison ivy).
UMLS ID:: C2609176
MeSH ID:: D000074962

Classification 1:

Name:

Cardiovascular Diseases
MeSH Tree Number(s):: C14.280.647.375|C14.907.585.375

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.543.560

Synonym(s)

Kounis Syndrome

Kounis syndrome

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Diclofenac	FAERS: 45	US FAERS
2	Ibuprofen	FAERS: 45 Canada Vigilance: 2	Canada Vigilance US FAERS
3	Levofloxacin	FAERS: 41	US FAERS
4	Cefuroxime	FAERS: 21	US FAERS
5	Amoxicillin	FAERS: 20	US FAERS
6	cefuroxime axetil	FAERS: 19	US FAERS
7	Amoxicillin-Potassium Clavulanate Combination	FAERS: 18	US FAERS
8	Arthrotec	FAERS: 18	US FAERS
9	Ciprofloxacin	FAERS: 16	US FAERS
10	Naproxen	FAERS: 16	US FAERS
11	Clarithromycin	FAERS: 13	US FAERS
12	Fluconazole	FAERS: 12 Canada Vigilance: 10	Canada Vigilance US FAERS
13	Ceftriaxone	FAERS: 11	US FAERS
14	Amoxicillin and clavulanic acid	FAERS: 10	US FAERS
15	Naproxen	FAERS: 8	US FAERS
16	Cefazolin	FAERS: 6	US FAERS
17	Cefuroxime	FAERS: 6	US FAERS
18	Clindamycin	FAERS: 6	US FAERS
19	Diclofenac	FAERS: 6	US FAERS
20	Vancomycin	FAERS: 6	US FAERS
21	Aspirin	FAERS: 5	US FAERS
22	Celecoxib	FAERS: 5	US FAERS
23	Doxycycline	FAERS: 5	US FAERS
24	Omeprazole	FAERS: 5	US FAERS
25	Amiodarone	FAERS: 4	US FAERS
26	Carboplatin	FAERS: 4	US FAERS
27	Clopidogrel	FAERS: 4	US FAERS
28	Epinephrine	FAERS: 4	US FAERS
29	Midazolam	FAERS: 4	US FAERS
30	Pantoprazole	FAERS: 4	US FAERS
31	Triamcinolone Acetonide	FAERS: 4	US FAERS
32	ziprasidone	FAERS: 4	US FAERS
33	Amiodarone	FAERS: 3	US FAERS
34	Ampicillin/sulbactam	FAERS: 3	US FAERS
35	Capecitabine	FAERS: 3	US FAERS
36	Cefaclor	FAERS: 3	US FAERS
37	Iohexol	FAERS: 3	US FAERS
38	Ketoprofen	FAERS: 3	US FAERS
39	Metoclopramide	FAERS: 3	US FAERS
40	Morphine	FAERS: 3	US FAERS
41	Nicotine	FAERS: 3	US FAERS
42	Pseudoephedrine	FAERS: 3	US FAERS
43	Sugammadex	FAERS: 3	US FAERS
44	Acetaminophen	FAERS: 2	SIDER US FAERS
45	Carisoprodol and aspirin	FAERS: 2	US FAERS
46	Ceftazidime	FAERS: 2	US FAERS
47	Cilostazol	FAERS: 2	US FAERS
48	Clindamycin	FAERS: 2	US FAERS
49	Esomeprazole	FAERS: 2	US FAERS
50	Metronidazole	FAERS: 2	US FAERS
51	Ranitidine	FAERS: 2	US FAERS
52	Tramadol	FAERS: 2	US FAERS
53	Vancomycin	FAERS: 2	US FAERS
54	iopromide	FAERS: 2	US FAERS
55	Amoxicillin	FAERS: 1	US FAERS
56	Azithromycin	FAERS: 1	US FAERS
57	Cefotaxime	FAERS: 1	US FAERS
58	Diclofenac Sodium and Misoprostol	FAERS: 1	US FAERS
59	Doxycycline	FAERS: 1	US FAERS
60	Ferric Oxide, Saccharated	FAERS: 1	US FAERS
61	Fluorouracil	FAERS: 1	US FAERS
62	Lansoprazole	FAERS: 1	US FAERS
63	Lorcet	FAERS: 1	US FAERS
64	Losartan	FAERS: 1	US FAERS
65	Mesalamine	FAERS: 1	US FAERS
66	Mesalamine	FAERS: 1	US FAERS
67	Midazolam	FAERS: 1	US FAERS
68	Omeprazole	FAERS: 1	US FAERS
69	Ondansetron	FAERS: 1	US FAERS
70	Rocuronium	FAERS: 1	US FAERS
71	Yosprala	FAERS: 1	US FAERS
72	clindamycin phosphate	FAERS: 1	US FAERS
73	contrast agent BR1	FAERS: 1	US FAERS
74	ioversol	FAERS: 1	US FAERS
75	reviparin	FAERS: 1	US FAERS
76	telithromycin	FAERS: 1	US FAERS
77	ziprasidone	FAERS: 1	US FAERS
78	mersyndol		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Coronary heart disease	43.2%
2	Myocardial Infarction	43.2%
3	Acute Coronary Syndrome	43.2%
4	Myocardial Reperfusion Injury	40.2%
5	Angina Pectoris	35.7%
6	Coronary Aneurysm	35.6%
7	Coronary Thrombosis	33.1%
8	Coronary Artery Disease	33.1%
9	Coronary Occlusion	32%
10	Microvascular Angina	32%
11	Coronary Stenosis	32%
12	ST segment elevation myocardial infarction	32%
13	Shock, Cardiogenic	26.7%
14	Coronary Restenosis	26.5%
15	Angina, Unstable	26.4%
16	Vasculitis, Leukocytoclastic, Cutaneous	23%
17	Angioedema	21.9%
18	Angina Pectoris, Variant	21.9%
19	Aortic Aneurysm	21.6%
20	Aortic Valve Stenosis	21.6%
21	Aortitis	21.6%
22	Cardiomyopathy, Dilated	21.6%
23	Leriche Syndrome	21.6%
24	Periphlebitis	21.6%
25	Phlebitis	21.6%
26	Pulmonary Valve Stenosis	21.6%
27	Thromboangiitis Obliterans	21.6%
28	Aneurysm	20.7%
29	Angiomatosis	20.7%
30	Aortic Diseases	20.7%
31	Arterial Occlusive Diseases	20.7%
32	Cardiac Tamponade	20.7%
33	Endocarditis	20.7%
34	Cardiac Arrest	20.7%
35	Heart failure	20.7%
36	Hyperemia	20.7%
37	Hypotension	20.7%
38	Immune Complex Diseases	20.7%
39	Pericardial effusion	20.7%
40	Pericarditis	20.7%
41	Pneumopericardium	20.7%
42	Cor pulmonale	20.7%
43	Superior Vena Cava Syndrome	20.7%
44	Telangiectasis	20.7%
45	Vasculitis	20.7%
46	Venous Insufficiency	20.7%
47	Ventricular Outflow Obstruction	20.7%
48	Peripheral Vascular Diseases	20.7%
49	Embolism and Thrombosis	20.7%
50	Angiodysplasia	20.7%
51	Ventricular Dysfunction	20.7%
52	Capillary Leak Syndrome	20.7%
53	Latex allergy	20.7%
54	Cardiomyopathies	20.7%
55	Pleuropericarditis	20.7%
56	Prehypertension	20.7%
57	Retinal Vein Occlusion	19.4%
58	Tricuspid Atresia	19.1%
59	Arrhythmogenic Right Ventricular Dysplasia	19.1%
60	Postphlebitic Syndrome	18.8%
61	Thrombophlebitis	18.7%
62	Heart Block	18%
63	Tachycardia	18%
64	Tachyarrhythmia	18%
65	Malignant Atrophic Papulosis	18%
66	Shwartzman Phenomenon	17.9%
67	Hypertrophic Cardiomyopathy	17.4%
68	Hypertrophic obstructive cardiomyopathy	17.4%
69	Aortic Rupture	17.2%
70	Vascular System Injuries	17.1%
71	Environmental Illness	17.1%
72	Blue Toe Syndrome	16.7%
73	Compartment syndromes	16.7%
74	Hepatic Veno-Occlusive Disease	16.7%
75	Peliosis Hepatis	16.7%
76	Varicocele	16.7%
77	Cardiac Output, High	16.7%
78	Myocardial Stunning	16.7%
79	Low Cardiac Output Syndrome	16.7%
80	Cerebrovascular Disorders	16.4%
81	Diabetic Angiopathies	16.4%
82	Cardiomegaly	16.4%
83	Postpericardiotomy Syndrome	16.4%
84	Reperfusion Injury	16.4%
85	Splenic Infarction	16.4%
86	Cerebrovascular Insufficiency	16.4%
87	Vascular Neoplasms	16.4%
88	Spinal Cord Vascular Diseases	16.4%
89	Cardiac Hypertrophy	16.4%
90	Vasoplegia	16.4%
91	Hemorrhoids	16.3%
92	Thoracic Outlet Syndrome	16.3%
93	Rheumatic Heart Disease	16.3%
94	Arteriovenous fistula	16.1%
95	No-Reflow Phenomenon	16.1%
96	Vasculitis, Central Nervous System	16%
97	Supravalvular aortic stenosis	16%
98	Lown-Ganong-Levine Syndrome	16%
99	Aortic Aneurysm, Abdominal	16%
100	Aortic Aneurysm, Thoracic	16%
101	Carotid Artery Thrombosis	16%
102	Serum Sickness	15.6%
103	Moyamoya Disease	15.6%
104	Intracranial Embolism and Thrombosis	15.6%
105	Carotid Stenosis	15.5%
106	Intracranial Aneurysm	15.5%
107	Long QT Syndrome	15.3%
108	anaphylaxis	15.3%
109	Food Allergy	15.3%
110	Anaphylactic shock	15.3%
111	Asthma, Aspirin-Induced	15.1%
112	Sick Sinus Syndrome	14.8%
113	Pregnancy Complications, Cardiovascular	14.3%
114	Cardiovascular Abnormalities	14.3%
115	Hand-Arm Vibration Syndrome	14.1%
116	Angioedemas, Hereditary	14.1%
117	Optic Neuropathy, Ischemic	13.8%
118	Anterior Ischemic Optic Neuropathy	13.8%
119	Mesenteric vascular insufficiency	13.8%
120	Bacterial Endocarditis	13.7%
121	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	13.6%
122	Hereditary Angioedema Type III	13.6%
123	Hereditary Angioedema Types I and II	13.6%
124	Aneurysm, Dissecting	13.6%
125	Aortic Valve Insufficiency	13.6%
126	Arteriosclerosis	13.6%
127	Arteritis	13.6%
128	Restrictive cardiomyopathy	13.6%
129	Embolism	13.6%
130	Embolism, Amniotic Fluid	13.6%
131	Endocardial Fibroelastosis	13.6%
132	Erythromelalgia	13.6%
133	Fibromuscular Dysplasia	13.6%
134	Heart Rupture, Post-Infarction	13.6%
135	Malignant Hypertension	13.6%
136	Mitral Valve Insufficiency	13.6%
137	Mitral Valve Stenosis	13.6%
138	Myocarditis	13.6%
139	Pericarditis, Constrictive	13.6%
140	Pulmonary Valve Insufficiency	13.6%
141	Raynaud Disease	13.6%
142	Thromboembolism	13.6%
143	Thrombosis	13.6%
144	Tricuspid Valve Insufficiency	13.6%
145	Tricuspid Valve Stenosis	13.6%
146	Essential Hypertension	13.6%
147	Aneurysm, Ruptured	13.6%
148	Iliac Aneurysm	13.6%
149	Pulmonary artery stenosis	13.6%
150	Ventricular Dysfunction, Left	13.6%
151	Right Ventricular Dysfunction	13.6%
152	White Coat Hypertension	13.6%
153	Systemic Vasculitis	13.6%
154	Endomyocardial Fibrosis	13.6%
155	Carditis	13.6%
156	Heart Failure, Systolic	13.6%
157	Heart Failure, Diastolic	13.6%
158	Embolus	13.6%
159	Giant Cell Arteritis	13.5%
160	Temporal Arteritis	13.5%
161	Colitis, Ischemic	13.4%
162	Aortic coarctation	13.4%
163	Cor Triatriatum	13.4%
164	Coronary Vessel Anomalies	13.4%
165	Patent ductus arteriosus	13.4%
166	Ebstein Anomaly	13.4%
167	Heart Septal Defects	13.4%
168	Tetralogy of Fallot	13.4%
169	Transposition of Great Vessels	13.4%
170	Hypoplastic Left Heart Syndrome	13.4%
171	May-Thurner Syndrome	13.4%
172	Polyarteritis Nodosa	13.3%
173	Takayasu Arteritis	13.3%
174	Adams-Stokes Syndrome	13.3%
175	Atrioventricular Block	13.3%
176	Bundle-Branch Block	13.3%
177	Atrial Premature Complexes	13.3%
178	Sinoatrial Block	13.3%
179	Tachycardia, Paroxysmal	13.3%
180	Supraventricular tachycardia	13.3%
181	Tachycardia, Ventricular	13.3%
182	Wolff-Parkinson-White Syndrome	13.3%
183	Tachycardia, Reciprocating	13.3%
184	Intracranial Arteriosclerosis	13.2%
185	Cerebral Atherosclerosis	13.2%
186	Cerebral Arteriosclerosis	13.2%
187	Respiratory Hypersensitivity	12.7%
188	Milk Allergy	12.6%
189	Wheat Hypersensitivity	12.6%
190	Sick Building Syndrome	12.3%
191	Multiple Chemical Sensitivity	12.3%
192	Scimitar Syndrome	12.2%
193	Urticaria	12.2%
194	Cerebral Thrombosis	12.1%
195	Intracranial Embolism	12.1%
196	Intracranial Thrombosis	12.1%
197	Dextrocardia	11.5%
198	Carcinoid Heart Disease	11.3%
199	Romano-Ward Syndrome	11.3%
200	Brain Infarction	11.3%
201	Retinal Artery Occlusion	11%
202	Tachycardia, Atrioventricular Nodal Reentry	11%
203	Tachycardia, Ectopic Atrial	11%
204	Tachycardia, Ectopic Junctional	11%
205	Sinus Tachycardia	11%
206	Torsades de Pointes	11%
207	Accelerated Idioventricular Rhythm	11%
208	Retinal Vasculitis	11%
209	Hypertensive Retinopathy	11%
210	Anterior Compartment Syndrome	10.8%
211	Sinus Arrhythmia	10.8%
212	Atrial Fibrillation	10.8%
213	Atrial Flutter	10.8%
214	Edema, Cardiac	10.8%
215	Ventricular Fibrillation	10.8%
216	Ventricular Flutter	10.8%
217	Parasystole	10.8%
218	Paroxysmal atrial fibrillation	10.8%
219	Gastric Antral Vascular Ectasia	10.8%
220	Bradycardia	10.8%
221	Diabetic Cardiomyopathies	10.8%
222	Abdominal Compartment Syndrome	10.8%
223	Cardiomyopathy, Alcoholic	10.7%
224	Carotid Artery Diseases	10.7%
225	Brain Ischemia	10.7%
226	Hypotension, Orthostatic	10.7%
227	Cerebrovascular accident	10.7%
228	Varicose Ulcer	10.7%
229	Sudden Cardiac Death	10.7%
230	Left Ventricular Hypertrophy	10.7%
231	Right Ventricular Hypertrophy	10.7%
232	Vasospasm, Intracranial	10.7%
233	Spinal Cord Ischemia	10.7%
234	Intracranial Arterial Diseases	10.7%
235	Primary Graft Dysfunction	10.7%
236	Post-Exercise Hypotension	10.7%
237	Lemierre Syndrome	10.7%
238	Autoimmune Diseases	10.7%
239	Immunologic Deficiency Syndromes	10.7%
240	Immunoproliferative Disorders	10.7%
241	Immune reconstitution syndrome	10.7%
242	Immune Reconstitution Inflammatory Syndrome	10.7%
243	Chagas Cardiomyopathy	10.7%
244	Cryoglobulinemia	10.5%
245	Subarachnoid Hemorrhage, Traumatic	10.4%
246	Carotid Artery, Internal, Dissection	10.4%
247	Sinus Thrombosis, Intracranial	10.4%
248	Multiple Myeloma	10.4%
249	CREST Syndrome	10.2%
250	Mastocytosis	10.2%
251	Drug Eruptions	10.1%
252	Aortic Valve Prolapse	10.1%
253	Arteriosclerosis Obliterans	10.1%
254	Atherosclerosis	10.1%
255	Air Embolism	10.1%
256	Endarteritis	10.1%
257	Tricuspid Valve Prolapse	10.1%
258	Venous Thrombosis	10.1%
259	Deep Vein Thrombosis	10.1%
260	Takotsubo Cardiomyopathy	10.1%
261	Venous Thromboembolism	10.1%
262	Infarction, Middle Cerebral Artery	10.1%
263	Infarction, Anterior Cerebral Artery	10.1%
264	Infarction, Posterior Cerebral Artery	10.1%
265	Dermatitis, Allergic Contact	10%
266	Mastocytosis, Systemic	10%
267	Vertebral Artery Dissection	9.9%
268	Aortopulmonary Septal Defect	9.9%
269	Double Outlet Right Ventricle	9.9%
270	Endocardial Cushion Defects	9.9%
271	Myocardial bridging	9.9%
272	Aorticopulmonary Septal Defect	9.9%
273	Cavernous Sinus Thrombosis	9.5%
274	Sagittal Sinus Thrombosis	9.5%
275	Cerebral Infarction	9.3%
276	Brain Stem Infarctions	9.3%
277	Mesenteric Vascular Occlusion	9.1%
278	Mucocutaneous Lymph Node Syndrome	9.1%
279	Diabetic Retinopathy	9%
280	Sturge-Weber Syndrome	9%
281	Livedo Reticularis	9%
282	Noonan Syndrome	9%
283	Dyspnea, Paroxysmal	8.9%
284	Renal hypertension	8.9%
285	Renal Artery Obstruction	8.9%
286	Renal Artery Stenosis	8.9%
287	Heart Diseases	8.9%
288	Vascular Diseases	8.9%
289	Granulomatosis with polyangiitis	8.9%
290	Hemangioma, Cavernous	8.9%
291	Basal Ganglia Cerebrovascular Disease	8.9%
292	Vascular Headaches	8.9%
293	Scurvy	8.9%
294	Carotid Artery Injuries	8.8%
295	Transfusion Reaction	8.6%
296	Hypotensive Transfusion Reaction	8.6%
297	Lateral Medullary Syndrome	8.4%
298	Myocardial Ischemia	8.3%
299	Subacute Bacterial Endocarditis	8.3%
300	Acute Generalized Exanthematous Pustulosis	8.3%
301	Truncus Arteriosus, Persistent	8.2%
302	Lupus Vasculitis, Central Nervous System	8.2%
303	Intermittent Claudication	8.2%
304	Pulmonary Embolism	8.2%
305	Waldenstrom Macroglobulinemia	8.1%
306	Marfan Syndrome	8.1%
307	Ataxia Telangiectasia	8.1%
308	Sinus Arrest, Cardiac	8%
309	Cerebral Arterial Diseases	8%
310	Vertebrobasilar Insufficiency	8%
311	Anterior Spinal Artery Syndrome	8%
312	Basilar Artery Stenosis	8%
313	Vertebral Artery Stenosis	8%
314	Intracranial Hemorrhage, Hypertensive	8%
315	Transient Cerebral Ischemia	8%
316	Basal Ganglia Hemorrhage	7.9%
317	Ischemic contracture	7.7%
318	Leukomalacia, Periventricular	7.6%
319	Diabetic Foot	7.6%
320	Dermatitis, Atopic	7.6%
321	Asthma, Exercise-Induced	7.5%
322	Status Asthmaticus	7.5%
323	Rheumatoid Vasculitis	7.5%
324	Asthma	7.3%
325	Erythema Nodosum	7.1%
326	Dermatitis, Photoallergic	7.1%
327	Antiphospholipid Syndrome	6.9%
328	Autoimmune Lymphoproliferative Syndrome	6.9%
329	Glomerulonephritis, Membranoproliferative	6.8%
330	Putaminal Hemorrhage	6.8%
331	Hepatic Vein Thrombosis	6.8%
332	Budd-Chiari Syndrome	6.8%
333	Pulmonary Infarction	6.7%
334	Asthma, Occupational	6.6%
335	Shy-Drager Syndrome	6.6%
336	Hypertension, Renovascular	6.6%
337	Purpura, Hyperglobulinemic	6.6%
338	Subarachnoid Hemorrhage	6.6%
339	Subclavian Steal Syndrome	6.6%
340	Hypoxia-Ischemia, Brain	6.6%
341	Cerebral Hemorrhage	6.6%
342	Dementia, Vascular	6.5%
343	Farmer's Lung	6.5%
344	Hay fever	6.4%
345	Rhinitis, Allergic, Perennial	6.4%
346	Aspergillosis, Allergic Bronchopulmonary	6.3%
347	Behcet Syndrome	6%
348	Primary amyloidosis	5.7%
349	Monoclonal Gammopathy of Undetermined Significance	5.7%
350	Pituitary Apoplexy	5.7%
351	Lupus Erythematosus, Systemic	5.6%
352	Lymphoproliferative Disorders	5.6%
353	Overlap syndrome	5.6%
354	Toxic Epidermal Necrolysis	5.5%
355	Stevens-Johnson Syndrome	5.5%
356	Cerebral Amyloid Angiopathy	5.5%
357	Addison Disease	5.5%
358	Paraproteinemias	5.5%
359	Pemphigus	5.5%
360	Autoimmune thyroiditis	5.5%
361	Primary Adrenal Insufficiency	5.5%
362	Lymphopenia	5.4%
363	Autoimmune hepatitis	5.4%
364	Pseudoxanthoma Elasticum	5.4%
365	Ectopia Cordis	5.4%
366	Single umbilical artery	5.4%
367	Autoimmune thrombocytopenia	5.3%
368	Immune thrombocytopenic purpura	5.3%
369	Thrombocytopenic purpura	5.1%
370	Turner Syndrome	4.9%
371	Williams Syndrome	4.8%
372	Hypergammaglobulinemia	4.6%
373	Latent Autoimmune Diabetes in Adults	4.6%
374	Agammaglobulinemia	4.5%
375	Dermatitis Herpetiformis	4.5%
376	Kounis Syndrome	4.5%
377	HIV Infections	4.5%
378	Transfusion-Related Acute Lung Injury	4.5%
379	Schnitzler Syndrome	4.2%
380	Sezary Syndrome	4.2%
381	Plasmacytoma	4.1%
382	Tumor Lysis Syndrome	4.1%
383	HTLV-I Infections	4%
384	Kartagener Syndrome	4%
385	Job Syndrome	4%
386	Kearns-Sayre syndrome	4%
387	Rheumatoid Arthritis	3.9%
388	Juvenile arthritis	3.9%
389	Graves Disease	3.9%
390	Dural Arteriovenous Fistula	3.9%
391	Anti-Glomerular Basement Membrane Disease	3.8%
392	Myasthenia Gravis, Autoimmune, Experimental	3.7%
393	Hematoma, Subdural	3.6%
394	Hematoma, Epidural, Cranial	3.6%
395	Lymphoma	3.4%
396	Myasthenia Gravis	3.4%
397	Uveomeningoencephalitic Syndrome	3.4%
398	Chronic granulomatous disease	3.4%
399	Heavy Chain Disease	3.4%
400	HIV Seropositivity	3.3%
401	Brain Hemorrhage, Traumatic	3.3%
402	MELAS Syndrome	3.3%
403	Hematoma, Subdural, Intracranial	3.2%
404	Hematoma, Subdural, Chronic	3.2%
405	Hematoma, Subdural, Acute	3.2%
406	Kernicterus	3%
407	Stiff-Person Syndrome	2.9%
408	Polyradiculoneuropathy	2.9%
409	Polyradiculoneuritis	2.9%
410	Acquired Immunodeficiency Syndrome	2.9%
411	AIDS related complex	2.9%
412	Infectious Mononucleosis	2.9%
413	Felty Syndrome	2.9%
414	POEMS Syndrome	2.9%
415	Neuromyelitis Optica	2.8%
416	Lupus Nephritis	2.8%
417	Leukoencephalitis, Acute Hemorrhagic	2.8%
418	Multiple Sclerosis	2.8%
419	Hodgkin Disease	2.8%
420	Leukemia, Plasma Cell	2.8%
421	Lymphoma, Non-Hodgkin	2.8%
422	Leukemia, T-Cell	2.8%
423	Leukemia, B-Cell	2.8%
424	Hydrops Fetalis	2.7%
425	Fabry Disease	2.6%
426	AIDS-Related Opportunistic Infections	2.5%
427	HIV Wasting Syndrome	2.5%
428	AIDS Dementia Complex	2.5%
429	AIDS-Associated Nephropathy	2.5%
430	Multiple Sclerosis, Chronic Progressive	2.5%
431	Multiple Sclerosis, Relapsing-Remitting	2.5%
432	Lymphoma, Follicular	2.5%
433	T-Cell Lymphoma	2.5%
434	Mantle cell lymphoma	2.5%
435	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
436	Leukemia, Large Granular Lymphocytic	2.5%
437	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.5%
438	Composite Lymphoma	2.4%
439	Encephalomyelitis, Acute Disseminated	2.4%
440	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	2.4%
441	Neuritis, Autoimmune, Experimental	2.4%
442	Lymphangioleiomyomatosis	2.4%
443	Lymphoma, T-Cell, Cutaneous	2.3%
444	Lymphoma, AIDS-Related	2.3%
445	Enteropathy-Associated T-Cell Lymphoma	2.3%
446	Primary Effusion Lymphoma	2.3%
447	Mycosis Fungoides	2.2%
448	Lymphomatoid Papulosis	2.2%
449	Plasmablastic lymphoma	2.2%
450	Lambert-Eaton Myasthenic Syndrome	2.2%
451	Wiskott-Aldrich Syndrome	2.2%
452	Sicca Syndrome	2.2%
453	Sjogren's Syndrome	2.2%
454	HIV-Associated Lipodystrophy Syndrome	2.2%
455	Guillain-Barre Syndrome	2.1%
456	Lymphomatoid Granulomatosis	2%
457	Burkitt Lymphoma	1.7%
458	Myelitis, Transverse	1.5%
459	Miller Fisher Syndrome	1.4%

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